amoxicillin-potassium-clavulanate-combination and Bites--Human

The rate of infection after a human bite is 10%-30%. Streptococcus spp. are the most common pathogens that may cause serious infections, such as necrotizing fasciitis. The authors describe a 5-year-old girl admitted to the emergency room with cellulitis due to S. pyogenes after human bites. She presented with fever and pain in her left arm, and her medical history revealed a human bite by her cousin on the arm 3 days prior. The wound culture yielded S. pyogenes. She was successfully treated with intravenous ampicillin-sulbactam regimen. S. pyogenes may cause serious wound infections following human bites. In such cases, the patient should be closely followed. Chemoprophylaxis should be initiated in an appropriate clinical setting to prevent secondary bacterial infections. This case was first reported as cellulitis due to S. pyogenes after a human bite.

Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Arm; Bites, Human; Cellulitis; Child, Preschool; Female; Humans; Streptococcal Infections; Streptococcus pyogenes; Treatment Outcome

Topics: Amoxicillin-Potassium Clavulanate Combination; Animals; Animals, Domestic; Bites and Stings; Bites, Human; Disease Transmission, Infectious; Disease Vectors; Humans; Primates; Rabies Vaccines; Risk Factors; Rodentia; Tetanus Toxoid; Wound Infection

Human bites to the hand or penetrating injuries contaminated with saliva can be a source of aggressive infection and debilitating injury. These types of injuries may also be a mode for the transmission of disease, notably hepatitis B. Dental personnel have an increased risk of experiencing bite injuries and should understand the general principles of appropriate management. Staphylococcal or streptococcal species are often associated with infected bite injuries, and amoxicillin and clavulanate are currently advised for prophylaxis. Wound cleansing and careful monitoring, combined with appropriate prophylaxis, are the mainstays of treatment.

Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Antibiotic Prophylaxis; Bacterial Infections; Bites, Human; Clavulanic Acids; Dentistry; Drug Therapy, Combination; Hand Injuries; Humans; Occupational Diseases

Topics: Administration, Oral; Adult; Amoxicillin-Potassium Clavulanate Combination; Bites, Human; C-Reactive Protein; Cellulitis; Doxycycline; Edema; Humans; Injections, Intravenous; Lymphadenitis; Male; Middle Aged; Penile Diseases; Penis; Pristinamycin; Sexual Behavior; Wound Infection

Human bite on genitalia is a rare cause of penile ulceration, but is increasingly being reported, probably due to the increasing frequency of orogenital sex. The great morbidity associated with it brings it under the category of high-risk bite wounds, similar to those on hands, feet and joints. We report a case and review the literature on human bite-induced penile ulceration.

Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Bites, Human; Drug Therapy, Combination; Humans; Male; Penile Diseases; Sexual Behavior; Skin Ulcer

Human bite injuries, while less frequent than cat or dog bites, usually stem from aggressive behavior, sports, or sexual activity. It has been thought that human bites have a higher rate of infection than animal bites, but this view is likely skewed because of the frequency of closed fist injuries presenting to emergency rooms. Human bites to the genitalia also occur, but are not often reported because of embarrassment.. We report a genital ulceration after a human bite to the penis and review appropriate diagnostic and therapeutic maneuvers.. This article reports the development of a severe genital ulcer associated with a human bite to the penis secondarily infected, as verified by culture, with an oral flora organism Eikenella corrodens.. The genital ulceration healed after appropriate antibiotic therapy.. Treatment of human bites focuses on obtaining an accurate history and performing a salient physical examination, as well as early irrigation and debridement. Transmission of communicable disease should be considered as a possible consequence. Prophylactic antibiotic treatment and primary closure of wounds continue to be areas of controversy.

Topics: Aged; Amoxicillin-Potassium Clavulanate Combination; Bites, Human; Ceftriaxone; Drug Therapy, Combination; Eikenella corrodens; Gram-Negative Bacterial Infections; Humans; Male; Penile Diseases; Penis; Ulcer

Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Bites, Human; Ceftriaxone; Debridement; Drug Therapy, Combination; Hand Injuries; Humans; Male; Metronidazole; Tetanus; Therapeutic Irrigation

We studied the comparative in vitro activities of 10 oral antimicrobial agents against 147 aerobic and 61 anaerobic bacteria making up species in 13 genera (Staphylococcus aureus, streptococci, Eikenella corrodens, Pasteurella multocida, Haemophilus-Actinobacillus spp., M-5, EF-4, Moraxella spp., Flavobacterium IIb, Bacteroides melaninogenicus, Bacteroides spp., Fusobacterium spp., and Peptostreptococcus spp.) that were isolated from bite wounds. Cefuroxime was generally greater than fourfold more active than cephalexin and cefadroxil against all aerobic isolates, including Pasteurella multocida. The fluoroquinolones were highly active against most aerobic isolates but were less active against anaerobic isolates. Ciprofloxacin was generally more active than either enoxacin or ofloxacin. Discrepancies of greater than 30% in the interpretation of susceptibilities between break points suggested by the National Committee for Clinical Laboratory Standards and those related to oral dose peak levels (one-half to one-quarter of maximum achievable concentrations) were noted in 14% (18 of 130) of the instances.

Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Infective Agents; Bacteria; Bites and Stings; Bites, Human; Cats; Cefuroxime; Cephalosporins; Ciprofloxacin; Clavulanic Acids; Dogs; Drug Therapy, Combination; Enoxacin; Humans; Ofloxacin; Wound Infection