amoxicillin-potassium-clavulanate-combination and Arthritis--Reactive

Reactional joint disease subsequent to digestive tract infections have been well studied for Salmonella, Shigella, Yersinia and Campylobacter. Association with HLA B27 is well documented. A review of the literature since 1976 disclosed 23 cases of articular and extra-articular inflammatory reactions following pseudomembranous Clostridium difficile infection.. We describe 2 new cases which followed a favorable course. This is the usual outcome although inflammatory manifestations may persist or relapse.. The pathophysiological interest of this condition lies in the pathogenic potential of Clostridium difficile which appears to be directly related to toxin production. This would suggest an immune mechanism rather than pure infection.

Topics: Adult; Aged; Amikacin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Reactive; Clostridioides difficile; Diclofenac; Drug Therapy, Combination; Enterocolitis, Pseudomembranous; Feces; Female; Follow-Up Studies; Humans; Ketoprofen; Male; Metronidazole; Middle Aged; Recurrence; Time Factors