amoxapine has been researched along with Seizures in 24 studies
Amoxapine: The N-demethylated derivative of the antipsychotic agent LOXAPINE that works by blocking the reuptake of norepinephrine, serotonin, or both; it also blocks dopamine receptors. Amoxapine is used for the treatment of depression.
amoxapine : A dibenzooxazepine compound having a chloro substituent at the 2-position and a piperazin-1-yl group at the 11-position.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Although she was initially treated with intravenous diazepam, her seizures persisted." | 8.31 | Successful Treatment of Amoxapine-Induced Intractable Seizures With Intravenous Lipid Emulsion. ( Imai, T; Iwabuchi, S; Kinoshita, K; Matsuoka, M, 2023) |
| "Two patients are described who experienced seizures while on therapeutic doses of amoxapine." | 7.67 | Amoxapine-induced seizures: case reports. ( Giannini, AJ; Price, WA, 1984) |
| "A 15-month-old infant had hyperpyrexia and severe generalized seizures without cardiovascular toxicity after the ingestion of 250 mg of amoxapine, a new tricyclic antidepressant of the dibenzoxapine subclass." | 7.66 | Amoxapine intoxication in an infant: seizures arrested with diazepam. ( Shepard, FM, 1983) |
| " Although she was initially treated with intravenous diazepam, her seizures persisted." | 4.31 | Successful Treatment of Amoxapine-Induced Intractable Seizures With Intravenous Lipid Emulsion. ( Imai, T; Iwabuchi, S; Kinoshita, K; Matsuoka, M, 2023) |
| "Amoxapine is a second-generation antidepressant that has been reported to cause seizures, severe acidosis, cardiac dysrhythmias, hypotension, renal failure, coma, and cardiorespiratory arrest in poisoning exposures." | 3.68 | Diagnostic pitfalls associated with amoxapine overdose: a case report. ( Greenwood, RS; Hussey, B; Miles, MV, 1990) |
| "Two patients are described who experienced seizures while on therapeutic doses of amoxapine." | 3.67 | Amoxapine-induced seizures: case reports. ( Giannini, AJ; Price, WA, 1984) |
| "A 15-month-old infant had hyperpyrexia and severe generalized seizures without cardiovascular toxicity after the ingestion of 250 mg of amoxapine, a new tricyclic antidepressant of the dibenzoxapine subclass." | 3.66 | Amoxapine intoxication in an infant: seizures arrested with diazepam. ( Shepard, FM, 1983) |
| "Nomifensine was withdrawn from markets worldwide because of reports of serious hypersensitivity reactions, especially hemolytic anemia, and marketing of bupropion in the United States was delayed after seizures occurred in bulimic patients in clinical trials." | 2.37 | Adverse reactions to five new antidepressants. ( Hayes, PE; Kristoff, CA, 1986) |
| "Acute renal failure, a brief seizure, and mild rhabdomyolysis developed in a 27-year-old man following overdosage with the tricyclic antidepressant, amoxapine." | 1.27 | Amoxapine-associated acute renal failure. ( Harrington, JT; Jennings, AE; Levey, AS, 1983) |
| "Seizures were more common in the amoxapine (24." | 1.27 | Relative toxicity of cyclic antidepressants. ( Gorman, RL; Klein-Schwartz, W; Oderda, GM; Wedin, GP, 1986) |
| "The effects of the chronic administration of antidepressants on threshold electroconvulsive (ECS) seizures were evaluated in rats." | 1.27 | Chronic but not acute treatment with antidepressants enhances the electroconvulsive seizure response in rats. ( Peterson, SL; St Mary, JS; Trzeciakowski, JP, 1985) |
| "At this time, because of the lack of knowledge and experience in the treatment of amoxapine toxicity, it is impossible to formulate any conclusions concerning this drug's true toxic potential and capabilities." | 1.26 | Amoxapine neurotoxicity: a case report with long-term follow-up. ( Browne, JL; Perry, PJ; Tsuang, MT, 1982) |
| "Amoxapine overdose could cause convulsions or prolonged coma leading to atraumatic rhabdomyolysis and myoglobinuric renal failure." | 1.26 | Amoxapine-associated rhabdomyolysis and acute renal failure: case report. ( Abero, K; Kosseff, A; Shelp, WD; Thomas, S, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (91.67) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Matsuoka, M | 3 |
| Imai, T | 3 |
| Iwabuchi, S | 3 |
| Kinoshita, K | 3 |
| Giannini, AJ | 1 |
| Price, WA | 1 |
| Rudorfer, MV | 1 |
| Golden, RN | 2 |
| Potter, WZ | 1 |
| Schurizek, BA | 1 |
| Rybro, L | 1 |
| Melsen, NC | 1 |
| Jefferson, JW | 1 |
| Rogol, AD | 1 |
| Schoumacher, R | 1 |
| Spyker, DA | 2 |
| Shepard, FM | 1 |
| Jennings, AE | 1 |
| Levey, AS | 1 |
| Harrington, JT | 1 |
| Litovitz, TL | 1 |
| Troutman, WG | 1 |
| Lopez, LM | 1 |
| Russell, WL | 1 |
| Smith, CA | 1 |
| Goldberg, MJ | 1 |
| Spector, R | 1 |
| Browne, JL | 1 |
| Tsuang, MT | 1 |
| Perry, PJ | 1 |
| Kulig, K | 1 |
| Rumack, BH | 1 |
| Sullivan, JB | 1 |
| Brandt, H | 1 |
| Duffy, JP | 1 |
| Shipe, JR | 1 |
| Abero, K | 1 |
| Shelp, WD | 1 |
| Kosseff, A | 1 |
| Thomas, S | 1 |
| Pumariega, AJ | 1 |
| Muller, B | 1 |
| Rivers-Bulkeley, NR | 1 |
| Bock, JL | 1 |
| Cummings, KC | 1 |
| Jatlow, PI | 1 |
| Miles, MV | 1 |
| Greenwood, RS | 1 |
| Hussey, B | 1 |
| Leonard, BE | 1 |
| Brown, TM | 1 |
| Miller, H | 1 |
| Evans, DL | 1 |
| Hayes, PE | 1 |
| Kristoff, CA | 1 |
| Wedin, GP | 1 |
| Oderda, GM | 1 |
| Klein-Schwartz, W | 1 |
| Gorman, RL | 1 |
| Peterson, SL | 1 |
| Trzeciakowski, JP | 1 |
| St Mary, JS | 1 |
3 reviews available for amoxapine and Seizures
| Article | Year |
|---|---|
Second-generation antidepressants.
Topics: Alprazolam; Amoxapine; Antidepressive Agents; Benzodiazepines; Bupropion; Citalopram; Clinical Trial | 1984 |
The new antidepressants.
Topics: Alprazolam; Amoxapine; Antidepressive Agents; Fluoxetine; Maprotiline; Nomifensine; Seizures; Trazod | 1988 |
Adverse reactions to five new antidepressants.
Topics: Acute Kidney Injury; Amoxapine; Animals; Antidepressive Agents; Bupropion; Cardiovascular Diseases; | 1986 |
1 trial available for amoxapine and Seizures
| Article | Year |
|---|---|
Second-generation antidepressants.
Topics: Alprazolam; Amoxapine; Antidepressive Agents; Benzodiazepines; Bupropion; Citalopram; Clinical Trial | 1984 |
21 other studies available for amoxapine and Seizures
| Article | Year |
|---|---|
Successful Treatment of Amoxapine-Induced Intractable Seizures With Intravenous Lipid Emulsion.
Topics: Adult; Amoxapine; Antidepressive Agents, Second-Generation; Diazepam; Fat Emulsions, Intravenous; Fe | 2023 |
Successful Treatment of Amoxapine-Induced Intractable Seizures With Intravenous Lipid Emulsion.
Topics: Adult; Amoxapine; Antidepressive Agents, Second-Generation; Diazepam; Fat Emulsions, Intravenous; Fe | 2023 |
Successful Treatment of Amoxapine-Induced Intractable Seizures With Intravenous Lipid Emulsion.
Topics: Adult; Amoxapine; Antidepressive Agents, Second-Generation; Diazepam; Fat Emulsions, Intravenous; Fe | 2023 |
Successful Treatment of Amoxapine-Induced Intractable Seizures With Intravenous Lipid Emulsion.
Topics: Adult; Amoxapine; Antidepressive Agents, Second-Generation; Diazepam; Fat Emulsions, Intravenous; Fe | 2023 |
Amoxapine-induced seizures: case reports.
Topics: Adult; Amoxapine; Antipsychotic Agents; Depressive Disorder; Dibenzoxazepines; Female; Humans; Male; | 1984 |
[Poisoning by amoxapine (Demolox). A new tricyclic antidepressive agent].
Topics: Acidosis; Adult; Amoxapine; Dibenzoxazepines; Female; Humans; Seizures; Suicide, Attempted; Tachycar | 1984 |
Amoxapine overdosage.
Topics: Amoxapine; Dibenzoxazepines; Humans; Seizures | 1984 |
Convulsions associated with amoxapine.
Topics: Adult; Amoxapine; Dibenzoxazepines; Female; Humans; Male; Middle Aged; Seizures | 1984 |
Generalized convulsions as the presenting sign of amoxapine intoxication.
Topics: Amoxapine; Coma; Dibenzoxazepines; Female; Humans; Infant; Kinetics; Seizures | 1984 |
Amoxapine intoxication in an infant: seizures arrested with diazepam.
Topics: Accidents, Home; Amoxapine; Diazepam; Dibenzoxazepines; Humans; Infant; Male; Seizures | 1983 |
Amoxapine-associated acute renal failure.
Topics: Acute Kidney Injury; Adult; Amoxapine; Depression; Dibenzoxazepines; Humans; Hypotension; Kidney Tub | 1983 |
Amoxapine overdose. Seizures and fatalities.
Topics: Adolescent; Adult; Amoxapine; Central Nervous System; Child; Child, Preschool; Dibenzoxazepines; Fem | 1983 |
Amoxapine overdose: case report and pharmacokinetic profile.
Topics: Amoxapine; Dibenzoxazepines; Female; Half-Life; Humans; Kinetics; Middle Aged; Seizures | 1983 |
Amoxapine overdose.
Topics: Amoxapine; Dibenzoxazepines; Female; Humans; Middle Aged; Seizures | 1982 |
Amoxapine overdose: report of two patients with severe neurologic damage.
Topics: Acidosis; Adult; Amoxapine; Brain Diseases; Coma; Dibenzoxazepines; Female; Humans; Hypokalemia; Sei | 1982 |
Amoxapine neurotoxicity: a case report with long-term follow-up.
Topics: Adult; Amoxapine; Blood Gas Analysis; Dibenzoxazepines; Female; Humans; Nervous System Diseases; Sei | 1982 |
Amoxapine overdose. Coma and seizures without cardiotoxic effects.
Topics: Adult; Amoxapine; Child; Coma; Dibenzoxazepines; Female; Half-Life; Heart; Humans; Male; Middle Aged | 1982 |
Amoxapine-associated rhabdomyolysis and acute renal failure: case report.
Topics: Acute Kidney Injury; Adult; Amoxapine; Coma; Creatine Kinase; Creatinine; Dibenzoxazepines; Female; | 1982 |
Acute renal failure secondary to amoxapine overdose.
Topics: Acute Kidney Injury; Adolescent; Amoxapine; Depressive Disorder; Dibenzoxazepines; Female; Humans; S | 1982 |
Amoxapine overdose: a case report.
Topics: Acidosis; Adult; Amoxapine; Coma; Dibenzoxazepines; Female; Humans; Seizures; Suicide, Attempted | 1982 |
Diagnostic pitfalls associated with amoxapine overdose: a case report.
Topics: Amoxapine; Child; Dibenzoxazepines; Electroencephalography; Emergencies; Female; Humans; Phenobarbit | 1990 |
Safety of amoxapine.
Topics: Amoxapine; Dibenzoxazepines; Drug Evaluation; Humans; Seizures | 1989 |
Relative toxicity of cyclic antidepressants.
Topics: Adolescent; Adult; Aged; Amoxapine; Anthracenes; Antidepressive Agents, Tricyclic; Arrhythmias, Card | 1986 |
Chronic but not acute treatment with antidepressants enhances the electroconvulsive seizure response in rats.
Topics: Amoxapine; Animals; Antidepressive Agents; Clomipramine; Convulsants; Desipramine; Electric Stimulat | 1985 |