amoxapine has been researched along with Neuroleptic Malignant Syndrome in 12 studies
Amoxapine: The N-demethylated derivative of the antipsychotic agent LOXAPINE that works by blocking the reuptake of norepinephrine, serotonin, or both; it also blocks dopamine receptors. Amoxapine is used for the treatment of depression.
amoxapine : A dibenzooxazepine compound having a chloro substituent at the 2-position and a piperazin-1-yl group at the 11-position.
Neuroleptic Malignant Syndrome: A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The case of a patient who developed the neuroleptic malignant syndrome following an overdose of amoxapine is presented." | 7.67 | Neuroleptic malignant syndrome following amoxapine overdose. ( Schwartz, HI; Taylor, NE, 1988) |
| "Amoxapine is a second-generation antidepressant possessing significant dopamine-blocking activity and extra-pyramidal side effects." | 5.28 | Amoxapine-induced neuroleptic malignant syndrome. ( Madakasira, S, 1989) |
| " Antidepressant and pravastatin were administered because of the patient's abulia and hypercholesterolemia, but neuroleptic malignant syndrome-like conditions developed." | 3.71 | [Unexpected drug-interaction]. ( Tajima, Y, 2002) |
| "A 63-year-old man with chronic renal failure who had received hemodialysis three times per week for 4 years developed neuroleptic malignant syndrome 10 days after taking amoxapine." | 3.70 | A case of neuroleptic malignant syndrome in a patient with hemodialysis. ( Kadono, M; Kunishima, Y; Masumori, N; Tsukamoto, T, 2000) |
| "The case of a patient who developed the neuroleptic malignant syndrome following an overdose of amoxapine is presented." | 3.67 | Neuroleptic malignant syndrome following amoxapine overdose. ( Schwartz, HI; Taylor, NE, 1988) |
| "Amoxapine is a second-generation antidepressant possessing significant dopamine-blocking activity and extra-pyramidal side effects." | 1.28 | Amoxapine-induced neuroleptic malignant syndrome. ( Madakasira, S, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (41.67) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Okamoto, K | 1 |
| Umeno, M | 1 |
| Takagi, H | 1 |
| Nagano, S | 1 |
| Takeda, Y | 1 |
| Sakamoto, A | 1 |
| Hoshino, T | 1 |
| Suzuki, H | 1 |
| Kimura, M | 1 |
| Ogawa, R | 1 |
| Kunishima, Y | 1 |
| Masumori, N | 1 |
| Kadono, M | 1 |
| Tsukamoto, T | 1 |
| Gupta, S | 1 |
| Racaniello, AA | 1 |
| Tajima, Y | 1 |
| Otani, K | 1 |
| Mihara, K | 1 |
| Okada, M | 1 |
| Kaneko, S | 1 |
| Fukushima, Y | 1 |
| Tam, CW | 2 |
| Madakasira, S | 1 |
| Washington, C | 1 |
| Haines, KA | 1 |
| Lesaca, T | 1 |
| Taylor, NE | 1 |
| Schwartz, HI | 1 |
| Burch, EA | 1 |
| Downs, J | 1 |
12 other studies available for amoxapine and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
[Case of malignant neuroleptic syndrome caused by an anti-depressive agent, later complicated by respiratory insufficiency and DIC].
Topics: Aged; Amitriptyline; Amoxapine; Disseminated Intravascular Coagulation; Female; Humans; Neuroleptic | 1998 |
Repeated propofol anesthesia for a patient with a history of neuroleptic malignant syndrome.
Topics: Amoxapine; Anesthesia, Intravenous; Anesthetics, Intravenous; Antidepressive Agents, Second-Generati | 1999 |
A case of neuroleptic malignant syndrome in a patient with hemodialysis.
Topics: Amoxapine; Antidepressive Agents, Second-Generation; Fatal Outcome; Humans; Male; Middle Aged; Neuro | 2000 |
Neuroleptic malignant syndrome associated with amoxapine and lithium in an older adult.
Topics: Amoxapine; Antidepressive Agents, Second-Generation; Antimanic Agents; Depressive Disorder; Humans; | 2000 |
[Unexpected drug-interaction].
Topics: Aged; Amoxapine; Anticholesteremic Agents; Antidepressive Agents, Second-Generation; Drug Interactio | 2002 |
Crossover reaction between haloperidol and amoxapine for NMS.
Topics: Aged; Amoxapine; Depressive Disorder; Dose-Response Relationship, Drug; Drug Therapy, Combination; F | 1991 |
Comment: repetitive publication of amoxapine and NMS case report.
Topics: Amoxapine; Duplicate Publications as Topic; Humans; Neuroleptic Malignant Syndrome; Publishing | 1990 |
Amoxapine-induced neuroleptic malignant syndrome.
Topics: Amoxapine; Bipolar Disorder; Dibenzoxazepines; Female; Humans; Middle Aged; Neuroleptic Malignant Sy | 1989 |
Amoxapine-induced neuroleptic malignant syndrome.
Topics: Amoxapine; Dibenzoxazepines; Humans; Male; Middle Aged; Neuroleptic Malignant Syndrome | 1989 |
Amoxapine and neuroleptic malignant syndrome.
Topics: Aged; Amoxapine; Depressive Disorder; Dibenzoxazepines; Drug Therapy, Combination; Female; Humans; L | 1987 |
Neuroleptic malignant syndrome following amoxapine overdose.
Topics: Adult; Amoxapine; Basal Ganglia Diseases; Catatonia; Diagnosis, Differential; Dibenzoxazepines; Fema | 1988 |
Development of neuroleptic malignant syndrome during simultaneous amoxapine treatment and alprazolam discontinuation.
Topics: Alprazolam; Amoxapine; Dibenzoxazepines; Female; Humans; Male; Middle Aged; Neuroleptic Malignant Sy | 1987 |