Page last updated: 2024-10-22

amodiaquine and Plasmodium vivax Malaria

amodiaquine has been researched along with Plasmodium vivax Malaria in 19 studies

Amodiaquine: A 4-aminoquinoline compound with anti-inflammatory properties.
amodiaquine : A quinoline having a chloro group at the 7-position and an aryl amino group at the 4-position.

Research Excerpts

ExcerptRelevanceReference
"In order to study the pharmacokinetic properties of amodiaquine and desethylamodiaquine during pregnancy, 24 pregnant women in the second and third trimesters of pregnancy and with Plasmodium vivax malaria were treated with amodiaquine (10 mg/kg of body weight/day) for 3 days."9.15Pharmacokinetics of amodiaquine and desethylamodiaquine in pregnant and postpartum women with Plasmodium vivax malaria. ( Cammas, M; Hsi, P; Jullien, V; Lindegardh, N; McGready, R; Nosten, F; Phyo, AP; Rijken, MJ; Singhasivanon, P; Tarning, J; White, NJ; Win, AK, 2011)
"Amodiaquine is effective for the treatment of Plasmodium vivax malaria, but there is little information on the pharmacokinetic and pharmacodynamic properties of amodiaquine in pregnant women with malaria."7.78Population pharmacokinetic and pharmacodynamic modeling of amodiaquine and desethylamodiaquine in women with Plasmodium vivax malaria during and after pregnancy. ( Bergstrand, M; Cammas, M; Chotsiri, P; Day, NP; Jullien, V; Lindegardh, N; McGready, R; Nosten, F; Rijken, MJ; Singhasivanon, P; Tarning, J; White, NJ, 2012)
"In order to study the pharmacokinetic properties of amodiaquine and desethylamodiaquine during pregnancy, 24 pregnant women in the second and third trimesters of pregnancy and with Plasmodium vivax malaria were treated with amodiaquine (10 mg/kg of body weight/day) for 3 days."5.15Pharmacokinetics of amodiaquine and desethylamodiaquine in pregnant and postpartum women with Plasmodium vivax malaria. ( Cammas, M; Hsi, P; Jullien, V; Lindegardh, N; McGready, R; Nosten, F; Phyo, AP; Rijken, MJ; Singhasivanon, P; Tarning, J; White, NJ; Win, AK, 2011)
" Chemopreventive strategies have been increasingly deployed in Africa, notably intermittent sulfadoxine-pyrimethamine treatment in pregnancy, and monthly amodiaquine-sulfadoxine-pyrimethamine during the rainy season months in children aged between 3 months and 5 years across the sub-Sahel."4.90Malaria. ( Dondorp, AM; Faiz, MA; Hien, TT; Mokuolu, OA; Pukrittayakamee, S; White, NJ, 2014)
"Amodiaquine is effective for the treatment of Plasmodium vivax malaria, but there is little information on the pharmacokinetic and pharmacodynamic properties of amodiaquine in pregnant women with malaria."3.78Population pharmacokinetic and pharmacodynamic modeling of amodiaquine and desethylamodiaquine in women with Plasmodium vivax malaria during and after pregnancy. ( Bergstrand, M; Cammas, M; Chotsiri, P; Day, NP; Jullien, V; Lindegardh, N; McGready, R; Nosten, F; Rijken, MJ; Singhasivanon, P; Tarning, J; White, NJ, 2012)
"The therapeutic efficacy of three monotherapies was assessed: amodiaquine and sulfadoxine/pyrimethamine for uncomplicated Plasmodium falciparum malaria, and chloroquine for Plasmodium vivax malaria in the municipality of Tarapacá, located in the Colombian province of Amazonas."3.74[Assessment of the efficacy of antimalarial drugs in Tarapacá, in the Colombian Amazon basin]. ( González, IJ; Osorio, L; Pérez, Ldel P, 2007)
"A high prevalence of chloroquine-resistant Plasmodium vivax in Indonesia has shifted first-line treatment to artemisinin-based combination therapies, combined with primaquine (PQ) for radical cure."2.78A randomized comparison of dihydroartemisinin-piperaquine and artesunate-amodiaquine combined with primaquine for radical treatment of vivax malaria in Sumatera, Indonesia. ( Chavez, I; Chokejindachai, W; Dondorp, AM; Imwong, M; Pasaribu, AP; Pasaribu, S; Sirivichayakul, C; Tanomsing, N; Tjitra, E; White, NJ, 2013)
"vivax malaria were treated according to the new policy guidelines (i."2.73Low efficacy of amodiaquine or chloroquine plus sulfadoxine-pyrimethamine against Plasmodium falciparum and P. vivax malaria in Papua New Guinea. ( Beck, HP; Genton, B; Goroti, M; Maku, P; Marfurt, J; Müeller, I; Reeder, JC; Sie, A, 2007)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19902 (10.53)18.7374
1990's1 (5.26)18.2507
2000's6 (31.58)29.6817
2010's10 (52.63)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Senn, N1
Rarau, P1
Manong, D1
Salib, M1
Siba, P1
Reeder, JC3
Rogerson, SJ1
Genton, B3
Mueller, I2
Andrianaranjaka, V1
Lin, JT1
Golden, C1
Juliano, JJ1
Randrianarivelojosia, M1
Pasaribu, AP1
Chokejindachai, W1
Sirivichayakul, C1
Tanomsing, N1
Chavez, I1
Tjitra, E2
Pasaribu, S1
Imwong, M1
White, NJ4
Dondorp, AM2
Pukrittayakamee, S1
Hien, TT1
Faiz, MA1
Mokuolu, OA1
Hetzel, MW1
Page-Sharp, M1
Bala, N1
Pulford, J1
Betuela, I1
Davis, TM1
Lavu, EK1
Fernández, D1
Segura, C1
Arboleda, M1
Garavito, G1
Blair, S1
Pabón, A1
Pava, Z1
Handayuni, I1
Wirjanata, G1
To, S1
Trianty, L1
Noviyanti, R1
Poespoprodjo, JR1
Auburn, S1
Price, RN2
Marfurt, J3
Siqueira, AM1
Alencar, AC1
Melo, GC1
Magalhaes, BL1
Machado, K1
Alencar Filho, AC1
Kuehn, A1
Marques, MM1
Manso, MC1
Felger, I1
Vieira, JL1
Lameyre, V1
Daniel-Ribeiro, CT1
Lacerda, MV1
de Monbrison, F1
Brega, S1
Barbollat, L1
Müller, I1
Sie, A2
Goroti, M2
Beck, HP2
Picot, S1
Rijken, MJ2
McGready, R2
Jullien, V2
Tarning, J2
Lindegardh, N2
Phyo, AP1
Win, AK1
Hsi, P1
Cammas, M2
Singhasivanon, P2
Nosten, F2
Chotsiri, P1
Bergstrand, M1
Day, NP1
LOVE, J1
FOULK, R1
WILLIAMS, RG1
MITCHELL, RB1
COURTNEY, KO1
HODGKINSON, R1
RAMSEY, R1
HAGGERTY, M1
Morrow, RH1
Hasugian, AR1
Purba, HL1
Kenangalem, E1
Wuwung, RM1
Ebsworth, EP1
Maristela, R1
Penttinen, PM1
Laihad, F1
Anstey, NM1
Osorio, L1
Pérez, Ldel P1
González, IJ1
Maku, P1
Nicolas, P1
Hovette, P1
Merouze, F1
Touze, JE1
Martet, G1
Collins, WE1
Sullivan, JS1
Fryauff, DJ1
Kendall, J1
Jennings, V1
Galland, GG1
Morris, CL1

Clinical Trials (8)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Intermittent Preventive Treatment (IPTi) for the Prevention of Malaria and Anaemia in PNG Infants[NCT00285662]1,100 participants (Anticipated)Interventional2006-06-30Completed
Comparison of the Efficacy and Safety of Two ACTs Plus Primaquine for Uncomplicated Plasmodium Vivax Malaria in North Sumatera, Indonesia: 1 Year Followup[NCT01288820]Phase 3331 participants (Actual)Interventional2011-01-31Completed
Incorporation of the 'Ottawa Malaria Decision Aid' Into the Pre-travel Consultation Process: Assessment of Travelers' Knowledge, Decisional Conflict, Preparation for Decision-making and Medication Adherence Compared to Standard Care[NCT01976325]100 participants (Anticipated)Interventional2014-01-31Recruiting
Infections in Migrants in Sweden - the Importance of Malaria and Other Parasitic Infections[NCT05086887]715 participants (Anticipated)Observational [Patient Registry]2019-04-15Recruiting
Clinical Efficacy of Artemisinin-based Combination Therapy for Treatment of Uncomplicated Plasmodium Falciparum Malaria in North Sumatera, Indonesia and the Association of Molecular Markers With Treatment Outcomes[NCT02325180]Phase 4338 participants (Actual)Interventional2015-01-31Completed
A Randomised Comparative Study to Assess the Efficacy and Tolerability of Blood Schizonticidal Treatments With Artesunate Amodiaquine Winthrop® / Coarsucam (ASAQ) Versus Chloroquine (CQ) for Uncomplicated Plasmodium Vivax Monoinfection Malaria[NCT01378286]Phase 3380 participants (Actual)Interventional2012-01-31Completed
Proof of Concept Study of Eurartesim® in Patients With Imported Uncomplicated Plasmodium Vivax Malaria[NCT02110784]Phase 227 participants (Actual)Interventional2014-06-18Terminated (stopped due to Low recruitment)
Efficacy of Chloroquine (CQ) Alone Compared to Concomitant CQ and Primaquine (PQ) for the Treatment of Uncomplicated Plasmodium Vivax Infection[NCT02691910]Phase 2/Phase 3204 participants (Actual)Interventional2014-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for amodiaquine and Plasmodium vivax Malaria

ArticleYear
Malaria.
    Lancet (London, England), 2014, Feb-22, Volume: 383, Issue:9918

    Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate

2014
Malaria.
    Lancet (London, England), 2014, Feb-22, Volume: 383, Issue:9918

    Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate

2014
Malaria.
    Lancet (London, England), 2014, Feb-22, Volume: 383, Issue:9918

    Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate

2014
Malaria.
    Lancet (London, England), 2014, Feb-22, Volume: 383, Issue:9918

    Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate

2014
Malaria.
    Lancet (London, England), 2014, Feb-22, Volume: 383, Issue:9918

    Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate

2014
Malaria.
    Lancet (London, England), 2014, Feb-22, Volume: 383, Issue:9918

    Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate

2014
Malaria.
    Lancet (London, England), 2014, Feb-22, Volume: 383, Issue:9918

    Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate

2014
Malaria.
    Lancet (London, England), 2014, Feb-22, Volume: 383, Issue:9918

    Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate

2014
Malaria.
    Lancet (London, England), 2014, Feb-22, Volume: 383, Issue:9918

    Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate

2014

Trials

6 trials available for amodiaquine and Plasmodium vivax Malaria

ArticleYear
Effectiveness of artemether/lumefantrine for the treatment of uncomplicated Plasmodium vivax and P. falciparum malaria in young children in Papua New Guinea.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2013, Volume: 56, Issue:10

    Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Child, Preschool; Ethanolamines; Fluorenes; Hu

2013
A randomized comparison of dihydroartemisinin-piperaquine and artesunate-amodiaquine combined with primaquine for radical treatment of vivax malaria in Sumatera, Indonesia.
    The Journal of infectious diseases, 2013, Dec-01, Volume: 208, Issue:11

    Topics: Adolescent; Adult; Aged; Amodiaquine; Antimalarials; Artemisinins; Child; Child, Preschool; Drug Com

2013
Fixed-Dose Artesunate-Amodiaquine Combination vs Chloroquine for Treatment of Uncomplicated Blood Stage P. vivax Infection in the Brazilian Amazon: An Open-Label Randomized, Controlled Trial.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017, Jan-15, Volume: 64, Issue:2

    Topics: Adolescent; Adult; Aged; Amodiaquine; Antimalarials; Artemisinins; Brazil; Child; Child, Preschool;

2017
Pharmacokinetics of amodiaquine and desethylamodiaquine in pregnant and postpartum women with Plasmodium vivax malaria.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:9

    Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Female; Humans; Malaria, Vivax; Postpartum Period; Pr

2011
Dihydroartemisinin-piperaquine versus artesunate-amodiaquine: superior efficacy and posttreatment prophylaxis against multidrug-resistant Plasmodium falciparum and Plasmodium vivax malaria.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2007, Apr-15, Volume: 44, Issue:8

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Artesunate; Drug Resistance, Multiple; Drug Toler

2007
Low efficacy of amodiaquine or chloroquine plus sulfadoxine-pyrimethamine against Plasmodium falciparum and P. vivax malaria in Papua New Guinea.
    The American journal of tropical medicine and hygiene, 2007, Volume: 77, Issue:5

    Topics: Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug R

2007

Other Studies

12 other studies available for amodiaquine and Plasmodium vivax Malaria

ArticleYear
Activation of minority-variant Plasmodium vivax hypnozoites following artesunate + amodiaquine treatment in a 23-year old man with relapsing malaria in Antananarivo, Madagascar.
    Malaria journal, 2013, May-31, Volume: 12

    Topics: Adult; Amodiaquine; Antimalarials; Artemisinins; Drug Combinations; Humans; Madagascar; Malaria, Viv

2013
Quality of antimalarial drugs and antibiotics in Papua New Guinea: a survey of the health facility supply chain.
    PloS one, 2014, Volume: 9, Issue:5

    Topics: Amodiaquine; Amoxicillin; Antimalarials; Artemether; Artemisinins; Biosimilar Pharmaceuticals; Chlor

2014
In vitro susceptibility of Plasmodium vivax to antimalarials in Colombia.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:11

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Chloroquine; Colombia; Drug Resistance; Malari

2014
Expression of Plasmodium vivax crt-o Is Related to Parasite Stage but Not Ex Vivo Chloroquine Susceptibility.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:1

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Resistance, Multiple; Erythr

2016
Molecular markers of in vivo Plasmodium vivax resistance to amodiaquine plus sulfadoxine-pyrimethamine: mutations in pvdhfr and pvmdr1.
    The Journal of infectious diseases, 2008, Aug-01, Volume: 198, Issue:3

    Topics: Amodiaquine; Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Child,

2008
Population pharmacokinetic and pharmacodynamic modeling of amodiaquine and desethylamodiaquine in women with Plasmodium vivax malaria during and after pregnancy.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:11

    Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Biotransformation; Body Weight; Drug Administration S

2012
Evaluation of amodiaquin (camoquin) in the treatment of relapsing vivax malaria.
    The American journal of the medical sciences, 1953, Volume: 225, Issue:1

    Topics: Amodiaquine; Malaria; Malaria, Vivax; Recurrence

1953
A combination of amodiaquin and primaquine (camoprim) in the prevention and cure of sporozoite-induced Chesson strain vivax malaria.
    The American journal of tropical medicine and hygiene, 1960, Volume: 9

    Topics: Amodiaquine; Animals; Antimalarials; Biomedical Research; Humans; Malaria, Vivax; Primaquine; Sporoz

1960
Antimalarial drug combinations in vastly different settings.
    Lancet (London, England), 2007, Feb-10, Volume: 369, Issue:9560

    Topics: Amodiaquine; Animals; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Burkin

2007
[Assessment of the efficacy of antimalarial drugs in Tarapacá, in the Colombian Amazon basin].
    Biomedica : revista del Instituto Nacional de Salud, 2007, Volume: 27, Issue:1

    Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Child; Child, Preschool; Colombia; Female; Humans; In

2007
[Cytokines and malaria. A study of TNF-alpha, IL1-beta, IL6 and IL2R in 28 patients].
    Bulletin de la Societe de pathologie exotique (1990), 1994, Volume: 87, Issue:2

    Topics: Adolescent; Adult; Amodiaquine; C-Reactive Protein; Chloroquine; Humans; Interleukin-1; Interleukin-

1994
Adaptation of a chloroquine-resistant strain of Plasmodium vivax from Indonesia to New World monkeys.
    The American journal of tropical medicine and hygiene, 2000, Volume: 62, Issue:4

    Topics: Adaptation, Physiological; Adult; Amodiaquine; Animals; Antimalarials; Aotidae; Child; Chloroquine;

2000