amodiaquine has been researched along with Neutropenia in 11 studies
Amodiaquine: A 4-aminoquinoline compound with anti-inflammatory properties.
amodiaquine : A quinoline having a chloro group at the 7-position and an aryl amino group at the 4-position.
Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Artesunate plus amodiaquine was highly efficacious for malaria treatment in HIV-infected children but was associated with a high risk of neutropenia, especially in the context of concurrent antiretroviral use." | 9.13 | High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda. ( Achan, J; Charlebois, E; Dorsey, G; Gasasira, AF; Havlir, D; Kalyango, JN; Kamya, MR; Kekitiinwa, A; Mebrahtu, T; Rosenthal, PJ; Ruel, T; Staedke, SG, 2008) |
| "Amodiaquine+SP is not well tolerated and a substantial proportion of patients experienced pruritus and fatigue, thus decreasing their compliance and compromising the first line treatment implementation at national level." | 9.12 | Tolerability of amodiaquine and sulphadoxine-pyrimethamine, alone or in combination for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan adults. ( D'Alessandro, U; Fanello, CI; Karema, C; Rwagacondo, CE; van Doren, W, 2006) |
| " Agranulocytosis seen with (i) beta-Lactam-antibiotics, (ii) vancomycin and (iii) amodiaquine can exemplify how simultaneous investigations of epidemiological and experimental aspects lead to identification of a subpopulation at risk." | 8.78 | [Evaluation of hematologic side effects of anti-infective therapy: agranulocytosis caused by beta-lactam antibiotics, vancomycin and amodiaquine]. ( Eich, G; Neftel, KA, 1991) |
| "6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken cotrimoxazole and another had taken sulphaguanidine." | 7.67 | Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria. ( Bunch, C; Edwards, G; Hatton, CS; Pasvol, G; Peto, TE; Russell, SJ; Singer, CR; Winstanley, P, 1986) |
| "A case of profound neutropenia and severe infection after the administration of amodiaquine is presented." | 7.65 | Amodiaquine agranulocytosis. ( Gillespie, P; Wagner, F, 1977) |
| "Artesunate plus amodiaquine was highly efficacious for malaria treatment in HIV-infected children but was associated with a high risk of neutropenia, especially in the context of concurrent antiretroviral use." | 5.13 | High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda. ( Achan, J; Charlebois, E; Dorsey, G; Gasasira, AF; Havlir, D; Kalyango, JN; Kamya, MR; Kekitiinwa, A; Mebrahtu, T; Rosenthal, PJ; Ruel, T; Staedke, SG, 2008) |
| "Amodiaquine+SP is not well tolerated and a substantial proportion of patients experienced pruritus and fatigue, thus decreasing their compliance and compromising the first line treatment implementation at national level." | 5.12 | Tolerability of amodiaquine and sulphadoxine-pyrimethamine, alone or in combination for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan adults. ( D'Alessandro, U; Fanello, CI; Karema, C; Rwagacondo, CE; van Doren, W, 2006) |
| " Agranulocytosis seen with (i) beta-Lactam-antibiotics, (ii) vancomycin and (iii) amodiaquine can exemplify how simultaneous investigations of epidemiological and experimental aspects lead to identification of a subpopulation at risk." | 4.78 | [Evaluation of hematologic side effects of anti-infective therapy: agranulocytosis caused by beta-lactam antibiotics, vancomycin and amodiaquine]. ( Eich, G; Neftel, KA, 1991) |
| "In a prospective longitudinal in vivo study, neutrophil rates were compared with malaria carriage after treatment with different ACTs: Artemether - lumefantrine (AL), Artesunate - amodiaquine (ASAQ), Dihydroartemisinin - piperaquine (DP) or Pyronaridine artesunate (PA)." | 4.31 | Variation in neutrophil levels and artemisinin-based combination therapy efficacy in West-Africa. ( Arama, C; Beavogui, AH; Dicko, A; Djimde, A; Djimde, M; Fofana, B; Kayentao, K; Mens, PF; Ouedraogo, JB; Sagara, I; Schallig, HD; Sirima, SB; Tshiongo, JK, 2023) |
| "6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken cotrimoxazole and another had taken sulphaguanidine." | 3.67 | Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria. ( Bunch, C; Edwards, G; Hatton, CS; Pasvol, G; Peto, TE; Russell, SJ; Singer, CR; Winstanley, P, 1986) |
| "Bone-marrow culture in soft agar was used to determine the cause of neutropenia in a visitor to Tanzania who had been taking both amodiaquine and proguanil for antimalarial prophylaxis." | 3.67 | Neutropenia associated with dual antimalarial chemoprophylaxis--use of bone-marrow culture as an aid in further drug management. ( Addison, GM; Ellis, ME; Steed, AJ, 1987) |
| "A case of profound neutropenia and severe infection after the administration of amodiaquine is presented." | 3.65 | Amodiaquine agranulocytosis. ( Gillespie, P; Wagner, F, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (36.36) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Djimde, M | 1 |
| Kayentao, K | 1 |
| Tshiongo, JK | 1 |
| Fofana, B | 1 |
| Arama, C | 1 |
| Sirima, SB | 1 |
| Ouedraogo, JB | 1 |
| Beavogui, AH | 1 |
| Sagara, I | 1 |
| Dicko, A | 1 |
| Mens, PF | 1 |
| Schallig, HD | 1 |
| Djimde, A | 1 |
| Hirschel, B | 1 |
| Fanello, CI | 1 |
| Karema, C | 1 |
| van Doren, W | 1 |
| Rwagacondo, CE | 1 |
| D'Alessandro, U | 1 |
| Gasasira, AF | 1 |
| Kamya, MR | 1 |
| Achan, J | 1 |
| Mebrahtu, T | 1 |
| Kalyango, JN | 1 |
| Ruel, T | 1 |
| Charlebois, E | 1 |
| Staedke, SG | 1 |
| Kekitiinwa, A | 1 |
| Rosenthal, PJ | 1 |
| Havlir, D | 1 |
| Dorsey, G | 1 |
| Olliaro, P | 1 |
| Gillespie, P | 1 |
| Wagner, F | 1 |
| Clarke, JB | 1 |
| Neftel, K | 1 |
| Kitteringham, NR | 1 |
| Park, BK | 1 |
| Eich, G | 1 |
| Neftel, KA | 1 |
| Hatton, CS | 1 |
| Peto, TE | 1 |
| Bunch, C | 1 |
| Pasvol, G | 1 |
| Russell, SJ | 1 |
| Singer, CR | 1 |
| Edwards, G | 1 |
| Winstanley, P | 1 |
| Carr, R | 1 |
| Ellis, ME | 1 |
| Steed, AJ | 1 |
| Addison, GM | 1 |
1 review available for amodiaquine and Neutropenia
| Article | Year |
|---|---|
[Evaluation of hematologic side effects of anti-infective therapy: agranulocytosis caused by beta-lactam antibiotics, vancomycin and amodiaquine].
Topics: Agranulocytosis; Amodiaquine; Animals; Anti-Bacterial Agents; beta-Lactams; Humans; Neutropenia; Van | 1991 |
2 trials available for amodiaquine and Neutropenia
| Article | Year |
|---|---|
Tolerability of amodiaquine and sulphadoxine-pyrimethamine, alone or in combination for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan adults.
Topics: Adult; Amodiaquine; Antimalarials; Blood Cell Count; Double-Blind Method; Drug Combinations; Drug Th | 2006 |
High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda.
Topics: Amodiaquine; Anti-HIV Agents; Antimalarials; Artemisinins; Artesunate; Chemoprevention; Child; Child | 2008 |
8 other studies available for amodiaquine and Neutropenia
| Article | Year |
|---|---|
Variation in neutrophil levels and artemisinin-based combination therapy efficacy in West-Africa.
Topics: Africa; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesun | 2023 |
Questions about the antimalarial amodiaquine.
Topics: Amodiaquine; Antimalarials; Humans; Malaria; Neutropenia | 2003 |
Disease and drug interactions: treating malaria with artesunate plus amodiaquine in patients also receiving treatment for concomitant HIV infection.
Topics: Amodiaquine; Anti-HIV Agents; Antimalarials; Artemisinins; Artesunate; Drug Interactions; Drug Thera | 2008 |
Amodiaquine agranulocytosis.
Topics: Adult; Agranulocytosis; Amodiaquine; Female; Humans; Neutropenia | 1977 |
Detection of antidrug IgG antibodies in patients with adverse drug reactions to amodiaquine.
Topics: Adult; Aged; Amodiaquine; Antibodies, Anti-Idiotypic; Chloroquine; Dose-Response Relationship, Immun | 1991 |
Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria.
Topics: Acute Disease; Adult; Agranulocytosis; Amodiaquine; Drug Combinations; Drug Therapy, Combination; Fe | 1986 |
Neutropenia and prophylactic amodiaquine.
Topics: Adolescent; Aged; Agranulocytosis; Amodiaquine; Humans; Malaria; Male; Middle Aged; Neutropenia | 1986 |
Neutropenia associated with dual antimalarial chemoprophylaxis--use of bone-marrow culture as an aid in further drug management.
Topics: Adult; Agranulocytosis; Amodiaquine; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Drug Therapy, | 1987 |