Page last updated: 2024-10-22

amodiaquine and Malaria

amodiaquine has been researched along with Malaria in 421 studies

Amodiaquine: A 4-aminoquinoline compound with anti-inflammatory properties.
amodiaquine : A quinoline having a chloro group at the 7-position and an aryl amino group at the 4-position.

Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.

Research Excerpts

ExcerptRelevanceReference
"IPTsc with dihydroartemisinin-piperaquine or artesunate-amodiaquine is a safe and effective approach to reducing malaria parasitaemia, clinical malaria, and related morbidities, and is feasible to implement through programmes delivered by schoolteachers."9.69Effectiveness and safety of intermittent preventive treatment with dihydroartemisinin-piperaquine or artesunate-amodiaquine for reducing malaria and related morbidities in schoolchildren in Tanzania: a randomised controlled trial. ( Baraka, V; Francis, F; Geertruyden, JV; Gesase, S; Kyaruzi, E; Lusingu, JPA; Madebe, R; Makenga, G; Minja, DTR; Mtove, G; Nakato, S, 2023)
"Artemether-lumefantrine plus amodiaquine provides an alternative to artemether-lumefantrine alone as first-line treatment for multidrug-resistant P falciparum malaria in the Greater Mekong subregion, and could prolong the therapeutic lifetime of artemether-lumefantrine in malaria-endemic populations."9.51Triple therapy with artemether-lumefantrine plus amodiaquine versus artemether-lumefantrine alone for artemisinin-resistant, uncomplicated falciparum malaria: an open-label, randomised, multicentre trial. ( Amaratunga, C; Callery, JJ; Chau, NH; Chotivanich, K; Chotsiri, P; Day, NPJ; Dhorda, M; Dondorp, AM; Duanguppama, J; Dung, NTP; Hien, TT; Hoglund, RM; Imwong, M; Lek, D; Long, LT; Maude, RJ; Miotto, O; Mukaka, M; Nghia, HDT; Nguon, C; Peto, TJ; Rekol, H; Ruecker, A; Sokha, M; Sovann, Y; Tarning, J; Thuong, NTH; Tripura, R; van der Pluijm, RW; Van Luong, V; von Seidlein, L; Waithira, N; White, NJ, 2022)
"Artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ) are the first line therapy of uncomplicated malaria in Burkina Faso."9.34Efficacy of artemether-lumefantrine and artesunate-amodiaquine as first line therapy of uncomplicated malaria in Burkina Faso, 11 years after policy change. ( Barry, N; Compaoré, YD; Kaboré, N; Nikiéma, F; Ouédraogo, JB; Somé, FA; Zongo, I; Zongo, M, 2020)
"The purpose of this study was to update efficacy data of Artesunate-Amodiaquine (AS+AQ) and Artemether-Lumefantrine (AL) used as first-line malaria treatment in Côte d'Ivoire since 2005."9.34Efficacy and safety of artesuante-amodiaquine and artemether lumefantrine, the first line malaria treatment in six sentinel's sites of Côte d'Ivoire, West Africa. ( Abba, T; Angora, EK; Assi, SB; Bedia, VA; Daho, AK; Emmanuel, B; Kiki-Barro, PMC; Konate, AA; Menan, H; Tiacoh, LN; Toure, OA; Yavo, W, 2020)
" Pyronaridine-artesunate and dihydroartemisinin-piperaquine are potentially useful for diversification of ACTs in this region, but further safety and efficacy data are required on malaria retreatment."9.27Pyronaridine-artesunate or dihydroartemisinin-piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial. ( , 2018)
"Amodiaquine plus artesunate is the recommended antimalarial treatment in many countries where malaria is endemic."9.27Population Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis To Optimize Dosing. ( Adjei, GO; Ali, AM; Aweeka, F; Barnes, KI; Denti, P; Jullien, V; Kiechel, JR; Kristensen, K; McGready, R; Mwesigwa, J; Penny, MA; Rijken, MJ; Sasi, P; Smith, TA; Stepniewska, K; Tarning, J; Workman, L, 2018)
"Based on per protocol analysis, unadjusted cure rates in malaria infected patients treated with artemether-lumefantrine (ALU), artesunate-amodiaquine (ASAQ) and dihydroartemisinin-piperaquine (DHP) were 89%, 94% and 91% respectively."9.22Therapeutic efficacy of artemether-lumefantrine, artesunate-amodiaquine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Sub-Saharan Africa: A systematic review and meta-analysis. ( Baraka, V; Kamugisha, E; Kapesa, A; Kidenya, B; Konje, E; Marwa, K; Mukonzo, J; Swedberg, G, 2022)
"It is recommended that children aged 3 months to five years of age living in areas of seasonal transmission in the sub-Sahel should receive Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine plus amodiaquine (SPAQ) during the malaria transmission season."9.22Safety of Seasonal Malaria Chemoprevention (SMC) with Sulfadoxine-Pyrimethamine plus Amodiaquine when Delivered to Children under 10 Years of Age by District Health Services in Senegal: Results from a Stepped-Wedge Cluster Randomized Trial. ( Ba, EH; Cairns, M; Cissé, B; Fall, FB; Faye, B; Gaye, O; Gomis, JF; Greenwood, BM; Kouevijdin, E; Milligan, PJ; Molez, JF; NDiaye, JL; Ndour, CT; Niane, FK; Rogier, C; Sokhna, C; Trape, JF, 2016)
"The WHO recommends that children living in areas of highly seasonal malaria transmission in the Sahel subregion should receive seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine plus amodiaquine (SPAQ)."9.20Randomized Noninferiority Trial of Dihydroartemisinin-Piperaquine Compared with Sulfadoxine-Pyrimethamine plus Amodiaquine for Seasonal Malaria Chemoprevention in Burkina Faso. ( Compaore, YD; Greenwood, B; Milligan, P; Nosten, F; Ouedraogo, JB; Rosenthal, PJ; Some, AF; Sutherland, C; Tarning, J; Zongo, I, 2015)
"To evaluate the comparative efficacy and safety of artemether-lumefantrine (AL), artesunate-amodiaquine (ASAQ) and artesunate-amodiaquine-chlorpheniramine (AQC) for the treatment of acute uncomplicated malaria among Southwest Nigerian children."9.19Evaluation of the comparative efficacy and safety of artemether-lumefantrine, artesunate-amodiaquine and artesunate-amodiaquine-chlorpheniramine (Artemoclo™) for the treatment of acute uncomplicated malaria in Nigerian children. ( Ademowo, OG; Dada-Adegbola, HO; Falade, CO; Nash, O; Oguike, MC; Ogunkunle, OO, 2014)
"6 mg/kg of amodiaquine per day) for the treatment of children and adults with uncomplicated falciparum malaria."9.16The efficacy and tolerability of artemisinin-piperaquine (Artequick®) versus artesunate-amodiaquine (Coarsucam™) for the treatment of uncomplicated Plasmodium falciparum malaria in south-central Vietnam. ( Chavchich, M; Dai, B; Edstein, MD; Phong, NC; Quang, HH; Shanks, GD; Thanh, NX; Trung, TN, 2012)
" A significantly higher proportion of children treated with artesunate-amodiaquine developed sinus bradycardia compared with artemether-lumefantrine treated subjects (7/47 vs 0/30; χ² p=0."9.16Electrocardiographic study in Ghanaian children with uncomplicated malaria, treated with artesunate-amodiaquine or artemether-lumefantrine. ( Adjei, GO; Alifrangis, M; Goka, BQ; Hoegberg, LC; Kurtzhals, JA; Oduro-Boatey, C; Rodrigues, OP, 2012)
"Pregnant women with non-severe, slide proven, falciparum malaria were randomised to one of 4 regimes: sulfadoxine-pyrimethamine [SP]; chlorproguanil-dapsone [CD]; SP+amodiaquine [SP+AQ] or amodiaquine+artesunate [AQ+AS]."9.14Randomized trial of artesunate+amodiaquine, sulfadoxine-pyrimethamine+amodiaquine, chlorproguanal-dapsone and SP for malaria in pregnancy in Tanzania. ( Briceño, M; Drakeley, C; Greenwood, BM; Mutabingwa, TK; Muze, K; Ord, R; Whitty, CJ, 2009)
"Sulfadoxine-pyrimethamine with amodiaquine (SP-AQ) is a highly efficacious regimen for intermittent preventive treatment to prevent malaria in children (IPTc), but the amodiaquine component is not always well tolerated."9.14Amodiaquine dosage and tolerability for intermittent preventive treatment to prevent malaria in children. ( Ba, EH; Cairns, M; Cames, C; Cisse, B; Gaye, O; Greenwood, BM; Milligan, PJ; Simondon, K; Sokhna, C; Trape, JF, 2010)
"Artesunate+amodiaquine (AS+AQ) and artemether-lumefantrine (AL) are now the most frequently recommended first line treatments for uncomplicated malaria in Africa."9.13An open label, randomised trial of artesunate+amodiaquine, artesunate+chlorproguanil-dapsone and artemether-lumefantrine for the treatment of uncomplicated malaria. ( Adjuik, M; Amenga-Etego, S; Asante, KP; Chandramohan, D; Dosoo, DK; Greenwood, B; Gyapong, J; Owusu, R; Owusu-Agyei, S, 2008)
"The in vivo therapeutic efficacy of the amodiaquine+sulfadoxine-pyrimethamine combination was evaluated in the treatment of uncomplicated Plasmodium falciparum malaria and of chloroquine for P."9.13[Efficacy of the amodiaquine+sulfadoxine-pyrimethamine combination and of chloroquine for the treatment of malaria in Córdoba, Colombia, 2006]. ( Cortés, LJ; Guerra, AP; Knudson, A; Nicholls, RS; Pérez, MA; Usta, C, 2008)
"The Home Management of Malaria (HMM) strategy was developed using chloroquine, a now obsolete drug, which has been replaced by artemisinin-based combination therapy (ACT) in health facility settings."9.13Feasibility and acceptability of artemisinin-based combination therapy for the home management of malaria in four African sites. ( Agyei-Baffour, P; Ajayi, IO; Balyeku, A; Bateganya, F; Browne, EN; Cousens, S; Doamekpor, L; Garshong, B; Munguti, K; Pagnoni, F; Yusuf, B, 2008)
"Artesunate plus amodiaquine was highly efficacious for malaria treatment in HIV-infected children but was associated with a high risk of neutropenia, especially in the context of concurrent antiretroviral use."9.13High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda. ( Achan, J; Charlebois, E; Dorsey, G; Gasasira, AF; Havlir, D; Kalyango, JN; Kamya, MR; Kekitiinwa, A; Mebrahtu, T; Rosenthal, PJ; Ruel, T; Staedke, SG, 2008)
"We undertook a trial of artesunate + amodiaquine (AS + AQ) and artesunate + sulphadoxine-pyrimethamine (AS + SP) in 180 children of age 6-59 months with uncomplicated malaria in Democratic Republic of Congo."9.12Artesunate + amodiaquine and artesunate + sulphadoxine-pyrimethamine for treatment of uncomplicated malaria in Democratic Republic of Congo: a clinical trial with determination of sulphadoxine and pyrimethamine-resistant haplotypes. ( Kayembe, G; Montgomery, J; Pota, H; Roper, C; Swarthout, TD; van den Broek, IV, 2006)
" The high endemicity of malaria in Africa may impact on the efficacy of artemisinin-based combination therapy."9.11Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. ( Bakyaita, N; Banek, K; Dorsey, G; Kamya, MR; Kilian, A; Kironde, F; Nsobya, SL; Reingold, A; Rosenthal, PJ; Slater, M; Staedke, SG; Talisuna, A; Wabwire-Mangen, F; Yeka, A, 2005)
"To compare the efficacy and side-effects of two therapeutic regimens for chloroquine-resistant falciparum malaria, a randomized study was carried out in 69 patients in Maputo Central Hospital in 1986-1987."9.06[Comparative study of sulfadoxine-pyrimethamine and amodiaquine + sulfadoxine-pyrimethamine for the treatment of malaria caused by chloroquine-resistant Plasmodium falciparum in Maputo, Mozambique]. ( Dinis, DV; Schapira, A, 1990)
" Fifty cases of falciparum malaria were treated with 1800 mg amodiaquine for 3 days: the cure rate was 65."9.06Effectiveness of amodiaquine, sulfadoxine-pyrimethamine, and combinations of these drugs for treating chloroquine-resistant falciparum malaria in Hainan Island, China. ( Cai, XZ; Fu, SG; Huang, JK; Huang, OL; Ouyang, WC; Pang, XJ; Wang, XF; Wu, Z; Zhang, KY; Zhou, JX, 1988)
"Amodiaquine was compared to chloroquine in two groups of Filipino patients with uncomplicated falciparum malaria."9.06Amodiaquine less effective than chloroquine in the treatment of falciparum malaria in the Philippines. ( Alban, P; Laughlin, LW; Long, GW; Padre, L; Ranoa, CP; Sangalang, R; Watt, G, 1987)
"Amodiaquine cured 38% (13/34) of patients with falciparum malaria in Southeast Thailand."9.04Amodiaquine resistant falciparum malaria in Thailand. ( Hall, AP; Kosakal, S; Pearlman, EJ; Phintuyothin, P; Segal, HE, 1975)
"The World Health Organization currently recommends quinine+clindamycin for use against malaria in the first trimester."8.95Animal Embryotoxicity Studies of Key Non-Artemisinin Antimalarials and Use in Women in the First Trimester. ( Clark, RL, 2017)
"Several African countries have begun using amodiaquine-containing combinations as first-line antimalarial treatment, with the result that a substantial number of pregnant women are likely to be exposed to amodiaquine."8.82Can amodiaquine be used safely during pregnancy? ( D'Alessandro, U; Erhart, A; Thomas, F, 2004)
"Amodiaquine and chloroquine give fast relief from malaria symptoms, particularly fever."8.81Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria. ( McIntosh, HM, 2001)
"A meta-analysis study evaluating the efficacy and safety of chloroquine and alternative antimalarial drugs used in six African countries including Ethiopia, Kenya, Uganda, Cote D'Ivoire, Gambia and Nigeria is presented."8.80Comparative efficacy and safety of chloroquine and alternative antimalarial drugs: a meta-analysis from six African countries. ( Makonnen, E; Mengesha, T, 1999)
"Amodiaquine has been widely used to treat malaria."8.80Amodiaquine for treating malaria. ( Mussano, P; Olliaro, P, 2000)
"Amodiaquine and chloroquine give fast relief from malaria symptoms, particularly fever."8.80Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria. ( McIntosh, HM, 2000)
"Between December, 2015, and March, 2016, and between December, 2017, and March, 2018, immediately following the 2015 and 2017 malaria transmission seasons, community surveys were done among children younger than 5 years and individuals aged 10-30 years in districts implementing seasonal malaria chemoprevention with sulfadoxine-pyrimethamine and amodiaquine in Burkina Faso, Chad, Guinea, Mali, Nigeria, Niger and The Gambia."8.31Prevalence of Plasmodium falciparum haplotypes associated with resistance to sulfadoxine-pyrimethamine and amodiaquine before and after upscaling of seasonal malaria chemoprevention in seven African countries: a genomic surveillance study. ( Bazie, T; Beshir, KB; Bojang, K; Cairns, M; Ceesay, S; Diallo, A; Dicko, A; Doumagoum, D; Eloike, T; Gamougam, K; Kessely, H; Kolie, F; Lamine, MM; Laminou, IM; Loua, K; Maiga, H; Mansukhani, R; Merle, CS; Milligan, P; Moroso, D; Muwanguzi, J; Nader, J; NDiaye, JL; Ogboi, SJ; Ouedraogo, JB; Razafindralambo, L; Sagara, I; Scott, S; Snell, P; Sutherland, CJ; Traore, A; Zongo, I, 2023)
"Artesunate-amodiaquine (ASAQ) and Artemether-lumefantrine (AL) are the recommended treatment for uncomplicated Plasmodium falciparum malaria in Liberia."8.12Artesunate-amodiaquine and artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in Liberia: in vivo efficacy and frequency of molecular markers. ( Asinya, M; Jeuronlon, MK; Kamara, P; Koko, VS; Kollie, A; Ma, L; Menard, D; Nyansaiye, P; Parwon, S; Pratt, OJ; Ringwald, P; Taweh, F; Tehmeh, L; Vonhm, B; Warsame, M, 2022)
"Based on reports of parasite resistance and on World Health Organization recommendation, chloroquine was replaced with the artemisinin-based combination therapies (ACTs) as the first choice of drugs for the treatment of uncomplicated malaria."8.02Treatment of COVID-19 with Chloroquine: Implication for Malaria Chemotherapy Using ACTs in Disease Endemic Countries. ( Duah-Quashie, NO; Quashie, NB, 2021)
"Co-administration of amodiaquine with MAMA decoction (MD), an herbal antimalarial drug comprising the leaves of Mangifera indica L."7.83Evaluation of herbal antimalarial MAMA decoction-amodiaquine combination in murine malaria model. ( Adepiti, AO; Bolaji, OO; Elujoba, AA, 2016)
" The lower-dose combination of the leaf extract and amodiaquine had better antimalarial activity in CQ-sensitive murine malaria."7.83Evaluation of the combination of Uvaria chamae (P. Beauv.) and amodiaquine in murine malaria. ( Adepiti, AO; Iwalewa, EO, 2016)
"Faced with intense levels of chloroquine (CQ) resistance in Plasmodium falciparum malaria, Rwanda replaced CQ with amodiaquine (AQ)+sulfadoxine-pyrimethamine (SP) in 2001, and subsequently with artemether-lumefantrine (AL) in 2006, as first-line treatments for uncomplicated malaria."7.83Molecular surveillance of Plasmodium falciparum drug resistance markers reveals partial recovery of chloroquine susceptibility but sustained sulfadoxine-pyrimethamine resistance at two sites of different malaria transmission intensities in Rwanda. ( Grobusch, MP; Hakizimana, E; Kateera, F; Kumar, N; Mens, PF; Mutesa, L; Nsobya, SL; Tukwasibwe, S; van Vugt, M, 2016)
"A novel class of benzoheterocyclic analogues of amodiaquine designed to avoid toxic reactive metabolite formation was synthesized and evaluated for antiplasmodial activity against K1 (multidrug resistant) and NF54 (sensitive) strains of the malaria parasite Plasmodium falciparum."7.81Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies. ( Chibale, K; Egan, TJ; Jurva, U; Masimirembwa, CM; Njoroge, M; Ongarora, DS; Strydom, N; Wicht, K; Wiesner, L; Wittlin, S, 2015)
"In 2003, artesunate-amodiaquine (AS+AQ) was introduced as the new first-line treatment for uncomplicated malaria in Burundi."7.74Community coverage of an antimalarial combination of artesunate and amodiaquine in Makamba Province, Burundi, nine months after its introduction. ( Brasher, C; Checchi, F; Cohuet, S; Edoh, K; Gerstl, S; Guthmann, JP; Lesage, A, 2007)
"Between 1998 and 2001, Kenya, Uganda, Tanzania, Zanzibar, Rwanda and Burundi changed antimalarial drug policy, in the face of widespread chloroquine resistance."7.72The efficacy of antimalarial monotherapies, sulphadoxine-pyrimethamine and amodiaquine in East Africa: implications for sub-regional policy. ( , 2003)
"Amodiaquine (AQ) (2) is a 4-aminoquinoline antimalarial that can cause adverse side effects including agranulocytosis and liver damage."7.72Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials. ( Bickley, JF; Bray, PG; Hindley, S; Hughes, RH; Maggs, JL; Mukhtar, A; O'Neil, IA; O'Neill, PM; Park, BK; Randle, LE; Stocks, PA; Storr, RC; Ward, SA; Winstanley, PA, 2003)
"Amodiaquine (AQ) is an antimalarial which is effective against chloroquino-resistant strains of Plasmodium falciparum but whose clinical use is severely restricted because of associated hepatotoxicity and agranulocytosis."7.71"One-pot" synthesis and antimalarial activity of formamidine derivatives of 4-anilinoquinoline. ( Dali Ali, F; Delarue, S; Girault, S; Grellier, P; Maes, L; Sergheraert, C, 2001)
"The activities of Mannich base antimalarials, including pyronaridine, have been explored against drug-sensitive (Plasmodium berghei N) and chloroquine-resistant (Plasmodium yoelii NS) rodent malaria parasites in vivo."7.68The chemotherapy of rodent malaria. XLVII. Studies on pyronaridine and other Mannich base antimalarials. ( Peters, W; Robinson, BL, 1992)
"The authors evaluate the comparative efficiency of chloroquine and amodiaquine (35 mg/kg during 3 days) for uncomplicated malaria treatment in an area with high chemoresistance level."7.68[Uncomplicated malaria attack in an area with high chloroquine resistance. 2. Evaluation of first-choice therapeutic scheme]. ( Arrive, A; Eberlé, F; Gazin, P; Hengy, C; Jambou, R; Kouka-Bemba, D, 1990)
" Oral amodiaquine (AQ) has been used to treat patients with symptomatic malaria in Zambia (n = 14) and Nigeria (n = 5)."7.68The disposition of amodiaquine in Zambians and Nigerians with malaria. ( Breckenridge, AM; Edwards, G; Kofi-Ekue, JM; Orme, ML; Salako, LA; Simooya, O; Walker, O; Winstanley, PA, 1990)
"In eastern Thailand, 14 adults with moderately severe falciparum malaria were treated with intravenous amodiaquine dihydrochloride, loading dose 10 mg base/kg infused over 4 h followed by three further intravenous infusions of 5 mg base/kg at 24, 48, and 72 h."7.67Intravenous amodiaquine and oral amodiaquine/erythromycin in the treatment of chloroquine-resistant falciparum malaria. ( Attanath, P; Benjasurat, Y; Karbwang, J; Looareesuwan, S; Phillips, RE; Warrell, DA; White, NJ, 1985)
"6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken cotrimoxazole and another had taken sulphaguanidine."7.67Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria. ( Bunch, C; Edwards, G; Hatton, CS; Pasvol, G; Peto, TE; Russell, SJ; Singer, CR; Winstanley, P, 1986)
"This report describes two patients who developed agranulocytosis while receiving prophylactic amodiaquine treatment."7.67Amodiaquine-induced immune agranulocytosis. ( Abel, L; Aymard, JP; Chau, F; Coulombel, L; Rouveix, B, 1989)
"Seven cases of agranulocytosis and two of liver damage that were probably due to amodiaquine treatment were studied."7.67Amodiaquine induced agranulocytosis and liver damage. ( Fehr, J; Frick, PG; Neftel, KA; Schmid, M; Woodtly, W, 1986)
"A death from chloroquinoresistant falciparum malaria contracted by a traveller under chloroquine chemoprophylaxis during a stay in the Cameroon provides the authors with an opportunity to analyze the extension of chloroquinoresistance in Africa."7.67[A fatal case of chloroquine-resistant neuromalaria in a traveller to Cameroon]. ( Beylot, J; Combe, A; Le Bras, J; Le Bras, M; Raccurt, CP; Ripert, C, 1986)
"Two patients are presented who during malaria prophylaxis with amodiaquine developed a hepatitis associated with granulocytopenia of short duration."7.67[Amodiaquine-induced hepatitis with leukopenia]. ( Siegrist, P; Vonmoos, P; Woodtli, W; Zollikofer, H, 1986)
"We report a patient who developed agranulocytosis following exposure to three drugs: amodiaquine, pyrimethamine and dipyrone."7.67Amodiaquine-induced agranulocytosis: drug inhibition of myeloid colonies in the presence of patient's serum. ( Douer, D; Ramot, B; Schwartz, E; Shaked, N, 1985)
"A combination of the drugs amodiaquine and tetracycline was used in a clinical trial at Phrabuddhabat Hospital in Central Thailand for treating Plasmodium falciparum malaria."7.66Treatment of Plasmodium falciparum malaria with a combination of amodiaquine and tetracycline in Central Thailand. ( Benjapong, W; Duriyananda, D; Malikul, S; Noeypatimanond, S; Ungkasrithongkul, M, 1983)
"A patient is presented who developed agranulocytosis while taking amodiaquine for suppressive therapy of malaria."7.66[Amodiaquine-induced agranulocytosis in malaria prevention: demonstration of an amodiaquine-induced cytotoxic antibody against granulocytes]. ( Gmür, J; Neftel, K; Schulthess, HK; von Felten, A, 1983)
"Evidence of resistance ot chloroquine was found in 13 out of 14 children from the East New Britain Province of Papua New Guinea, with Plasmodium falciparum malaria."7.66Chloroquine resistant Plasmodium falciparum malaria in East New Britain, Papua New Guinea. ( Tulloch, A, 1980)
"Intermittent preventive treatment of malaria among schoolchildren (IPTsc) reduces clinical malaria, asymptomatic parasitemia, and anemia."7.11Overall and Gender-Specific Effects of Intermittent Preventive Treatment of Malaria with Artemisinin-Based Combination Therapies among Schoolchildren in Mali: A Three-Group Open Label Randomized Controlled Trial. ( Bamadio, A; Chico, RM; Cohee, LM; Coumare, S; Dara, A; Diarra, M; Djimde, AA; Doumbo, OK; Kodio, A; Maiga, H; Opondo, C; Sagara, I; Sidibe, B; Tekete, M; Traore, OB; Traore, ZI, 2022)
"Children with sickle cell anemia (SCA) in areas of Africa with endemic malaria transmission are commonly prescribed malaria chemoprevention."7.11Monthly sulfadoxine/pyrimethamine-amodiaquine or dihydroartemisinin-piperaquine as malaria chemoprevention in young Kenyan children with sickle cell anemia: A randomized controlled trial. ( Clapp, S; Freedman, B; Green, CL; Kirui, JK; Korwa, S; Njuguna, FM; O'Meara, WP; Taylor, SM; Wu, A, 2022)
"Malaria is the leading cause of morbidity and mortality among infants and children under-five in sub-Saharan Africa."5.91Predictors of caregiver adherence to administration of amodiaquine during delivery of seasonal malaria chemoprevention in Nigeria, Burkina Faso, Chad, and Togo. ( Aidenagbon, A; Ibinaiye, T; Ogunmola, O; Oguoma, C; Oresanya, O; Rassi, C; Richardson, S, 2023)
"Malaria is the one of the deadliest infectious diseases worldwide."5.91Antimalarial Agents Derived from Metal-Amodiaquine Complexes with Activity in Multiple Stages of the Plasmodium Life Cycle. ( Araújo Nobrega, J; Azevedo Batista, A; Basilico, N; Colina-Vegas, L; D'Alessandro, S; da Cruz B Silva, M; de Souza Pereira, C; Isis Barros, A; Moreira, DRM; Navarro, M; Rottmann, M, 2023)
"Until recently, due to widespread prevalence of molecular markers associated with sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) resistance in east and southern Africa, seasonal malaria chemoprevention (SMC) has not been used at scale in this region."5.69A non-randomized controlled trial to assess the protective effect of SMC in the context of high parasite resistance in Uganda. ( Abio, H; Achan, J; Baker, K; Beinomugisha, G; Bonnington, C; Bwanika, JB; Kajubi, R; Kyagulanyi, T; Magumba, G; Marasciulo-Rice, M; Nabakooza, J; Nakirunda, M; Nuwa, A; Odong, DS; Odongo, M; Opigo, J; Rassi, C; Richardson, S; Rubahika, D; Rutazaana, D; Tibenderana, J, 2023)
"IPTsc with dihydroartemisinin-piperaquine or artesunate-amodiaquine is a safe and effective approach to reducing malaria parasitaemia, clinical malaria, and related morbidities, and is feasible to implement through programmes delivered by schoolteachers."5.69Effectiveness and safety of intermittent preventive treatment with dihydroartemisinin-piperaquine or artesunate-amodiaquine for reducing malaria and related morbidities in schoolchildren in Tanzania: a randomised controlled trial. ( Baraka, V; Francis, F; Geertruyden, JV; Gesase, S; Kyaruzi, E; Lusingu, JPA; Madebe, R; Makenga, G; Minja, DTR; Mtove, G; Nakato, S, 2023)
" The present study hence evaluated the effect of MD on the disposition of AQ in mice with a view to investigating a possible pharmacokinetic interaction."5.56Influence of MAMA decoction, an Herbal Antimalarial, on the Pharmacokinetics of Amodiaquine in Mice. ( Adeagbo, BA; Adehin, A; Adepiti, AO; Bolaji, OO; Elujoba, AA, 2020)
" Here, we evaluated the population pharmacokinetic properties of amodiaquine and its active metabolite, desethylamodiaquine, in children receiving SMC under directly observed ideal conditions (n = 136), and the adherence of SMC at an implementation phase in children participating in a case-control study to evaluate SMC effectiveness (n = 869)."5.56Adherence and Population Pharmacokinetic Properties of Amodiaquine When Used for Seasonal Malaria Chemoprevention in African Children. ( Assao, B; Blessborn, D; Coldiron, ME; Ding, J; Grais, RF; Guindo, O; Koscalova, A; Langendorf, C; Tarning, J; Winterberg, M, 2020)
" Thus, the efficacy of ASAQ is maintained and appears to be increased after long-term use in contrast to what is observed for other ACTs used in Africa."5.56Increased Sensitivity of Plasmodium falciparum to Artesunate/Amodiaquine Despite 14 Years as First-Line Malaria Treatment, Zanzibar. ( Abbas, FB; Ali, AS; Ali, AW; Barnes, R; Björkman, A; Frumento, P; Mårtensson, A; Morris, U; Msellem, M; Soe, A, 2020)
"Artemether-lumefantrine plus amodiaquine provides an alternative to artemether-lumefantrine alone as first-line treatment for multidrug-resistant P falciparum malaria in the Greater Mekong subregion, and could prolong the therapeutic lifetime of artemether-lumefantrine in malaria-endemic populations."5.51Triple therapy with artemether-lumefantrine plus amodiaquine versus artemether-lumefantrine alone for artemisinin-resistant, uncomplicated falciparum malaria: an open-label, randomised, multicentre trial. ( Amaratunga, C; Callery, JJ; Chau, NH; Chotivanich, K; Chotsiri, P; Day, NPJ; Dhorda, M; Dondorp, AM; Duanguppama, J; Dung, NTP; Hien, TT; Hoglund, RM; Imwong, M; Lek, D; Long, LT; Maude, RJ; Miotto, O; Mukaka, M; Nghia, HDT; Nguon, C; Peto, TJ; Rekol, H; Ruecker, A; Sokha, M; Sovann, Y; Tarning, J; Thuong, NTH; Tripura, R; van der Pluijm, RW; Van Luong, V; von Seidlein, L; Waithira, N; White, NJ, 2022)
"Antimalarial treatments with artesunate-pyronaridine and artemether-lumefantrine reduced the excretion of S."5.51Effectiveness of antimalarial drug combinations in treating concomitant urogenital schistosomiasis in malaria patients in Lambaréné, Gabon: A non-randomised event-monitoring study. ( Adegnika, AA; Akinosho, MA; Davi, SD; Dimessa-Mbadinga, LB; Handrich, C; Kreidenweiss, A; Kremsner, PG; Lell, B; Mombo-Ngoma, G; Ndzebe-Ndoumba, WF; Nordmann, T; Okwu, DG; Ramharter, M; Stelzl, D; Veletzky, L; Zoleko-Manego, R, 2022)
"Atovaquone-proguanil (ATV-PG) plus amodiaquine (AQ) has been considered as a potential replacement for sulfadoxine-pyrimethamine plus AQ for seasonal malaria chemoprevention in African children."5.51Unanticipated CNS Safety Signal in a Placebo-Controlled, Randomized Trial of Co-Administered Atovaquone-Proguanil and Amodiaquine. ( Abla, N; Chalon, S; Chughlay, MF; Haouala, A; Hutter, B; Lorch, U; Macintyre, F; Marie Tchouatieu, A, 2022)
"Artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ) are the first line therapy of uncomplicated malaria in Burkina Faso."5.34Efficacy of artemether-lumefantrine and artesunate-amodiaquine as first line therapy of uncomplicated malaria in Burkina Faso, 11 years after policy change. ( Barry, N; Compaoré, YD; Kaboré, N; Nikiéma, F; Ouédraogo, JB; Somé, FA; Zongo, I; Zongo, M, 2020)
"The purpose of this study was to update efficacy data of Artesunate-Amodiaquine (AS+AQ) and Artemether-Lumefantrine (AL) used as first-line malaria treatment in Côte d'Ivoire since 2005."5.34Efficacy and safety of artesuante-amodiaquine and artemether lumefantrine, the first line malaria treatment in six sentinel's sites of Côte d'Ivoire, West Africa. ( Abba, T; Angora, EK; Assi, SB; Bedia, VA; Daho, AK; Emmanuel, B; Kiki-Barro, PMC; Konate, AA; Menan, H; Tiacoh, LN; Toure, OA; Yavo, W, 2020)
" Pyronaridine-artesunate and dihydroartemisinin-piperaquine are potentially useful for diversification of ACTs in this region, but further safety and efficacy data are required on malaria retreatment."5.27Pyronaridine-artesunate or dihydroartemisinin-piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial. ( , 2018)
"Amodiaquine plus artesunate is the recommended antimalarial treatment in many countries where malaria is endemic."5.27Population Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis To Optimize Dosing. ( Adjei, GO; Ali, AM; Aweeka, F; Barnes, KI; Denti, P; Jullien, V; Kiechel, JR; Kristensen, K; McGready, R; Mwesigwa, J; Penny, MA; Rijken, MJ; Sasi, P; Smith, TA; Stepniewska, K; Tarning, J; Workman, L, 2018)
" A 25-mg base/kg dosage of amodiaquine produced parasite clearance in 34 of 38 (89%) children in a mean of 2."5.27Evaluation of amodiaquine treatment of chloroquine-resistant Plasmodium falciparum malaria on Zanzibar, 1982. ( Campbell, CC; Khatib, OJ; Payne, D; Schwartz, IK, 1983)
"Amodiaquine was not found in any sample, but the major metabolite monodesethylamodiaquine was detected and was assumed to be the sole derivative that contributed significantly to antimalarial activity in the blood."5.27Disposition of monodesethylamodiaquine after a single oral dose of amodiaquine and three regimens for prophylaxis against Plasmodium falciparum malaria. ( Blayo, MC; Faurisson, F; Le Bras, J; Pussard, E; Scherrmann, JM; Verdier, F, 1987)
" In an attempt to explain the discrepancy between its in vivo-in vitro activity, a pharmacokinetic study was conducted in healthy subjects with HPLC assays."5.27[Pharmacokinetics of amodiaquine and prevention of Plasmodium falciparum malaria]. ( Blayo, MC; Faurisson, F; Pussard, E; Verdier, F, 1985)
"Based on per protocol analysis, unadjusted cure rates in malaria infected patients treated with artemether-lumefantrine (ALU), artesunate-amodiaquine (ASAQ) and dihydroartemisinin-piperaquine (DHP) were 89%, 94% and 91% respectively."5.22Therapeutic efficacy of artemether-lumefantrine, artesunate-amodiaquine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Sub-Saharan Africa: A systematic review and meta-analysis. ( Baraka, V; Kamugisha, E; Kapesa, A; Kidenya, B; Konje, E; Marwa, K; Mukonzo, J; Swedberg, G, 2022)
" A total of 2400 children aged 3-59 months received either: (i) a short-acting ACT for case management of malaria (artemether-lumefantrine, AL) plus placebo SMC, or (ii) a long-acting ACT (dihydroartemisinin-piperaquine, DP) for case management plus placebo SMC or (iii) AL for case management plus active SMC with sulphadoxine-pyrimethamine and amodiaquine."5.22Seasonal malaria chemoprevention in an area of extended seasonal transmission in Ashanti, Ghana: an individually randomised clinical trial. ( Acheampong, PR; Antwi, GD; Bart Plange, C; Cairns, M; Chandramohan, D; Tagbor, H, 2016)
"It is recommended that children aged 3 months to five years of age living in areas of seasonal transmission in the sub-Sahel should receive Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine plus amodiaquine (SPAQ) during the malaria transmission season."5.22Safety of Seasonal Malaria Chemoprevention (SMC) with Sulfadoxine-Pyrimethamine plus Amodiaquine when Delivered to Children under 10 Years of Age by District Health Services in Senegal: Results from a Stepped-Wedge Cluster Randomized Trial. ( Ba, EH; Cairns, M; Cissé, B; Fall, FB; Faye, B; Gaye, O; Gomis, JF; Greenwood, BM; Kouevijdin, E; Milligan, PJ; Molez, JF; NDiaye, JL; Ndour, CT; Niane, FK; Rogier, C; Sokhna, C; Trape, JF, 2016)
"Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ), given each month during the transmission season, is recommended for children living in areas of the Sahel where malaria transmission is highly seasonal."5.22Effectiveness of Seasonal Malaria Chemoprevention in Children under Ten Years of Age in Senegal: A Stepped-Wedge Cluster-Randomised Trial. ( Ba, EH; Cairns, M; Cissé, B; Dial, Y; Fall, FB; Faye, B; Faye, E; Faye, O; Faye, OK; Faye, S; Flach, C; Gaye, O; Gomis, JF; Greenwood, B; Konate, L; Kouevijdin, E; Lo, A; Milligan, P; NDiaye, JL; NDiaye, M; Pitt, C; Sokhna, C; Sutherland, C; Sy, O; Thior, PM; Tine, R; Trape, JF, 2016)
" Pregnant women diagnosed with malaria are randomised to receive either amodiaquine-artesunate (AQ-AS), dihydroartemisinin-piperaquine (DHA-PQ), artemether-lumefantrine (AL), or mefloquine-artesunate (MQAS)."5.20Safe and efficacious artemisinin-based combination treatments for African pregnant women with malaria: a multicentre randomized control trial. ( Claeys, Y; D'Alessandro, U; De Crop, M; Halidou, T; Kalanda, G; Menten, J; Mulenga, M; Mutabingwa, T; Mwakazanga, D; Mwapasa, V; Nambozi, M; Phiri, LK; Ravinetto, R; Schurmans, C; Tagbor, H; Thriemer, K; Traore, M; Valea, I; Van Geertruyden, JP, 2015)
"Artemisinin-based combination therapies (ACTs) have been adopted by most African countries, including Nigeria, as first-line treatments for uncomplicated falciparum malaria."5.20Validation and pharmacokinetic application of a high-performance liquid chromatographic technique for determining the concentrations of amodiaquine and its metabolite in plasma of patients treated with oral fixed-dose amodiaquine-artesunate combination in ( Adedeji, ON; Ademowo, OG; Bolaji, OO; Falade, CO; Osonuga, OA, 2015)
"The WHO recommends that children living in areas of highly seasonal malaria transmission in the Sahel subregion should receive seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine plus amodiaquine (SPAQ)."5.20Randomized Noninferiority Trial of Dihydroartemisinin-Piperaquine Compared with Sulfadoxine-Pyrimethamine plus Amodiaquine for Seasonal Malaria Chemoprevention in Burkina Faso. ( Compaore, YD; Greenwood, B; Milligan, P; Nosten, F; Ouedraogo, JB; Rosenthal, PJ; Some, AF; Sutherland, C; Tarning, J; Zongo, I, 2015)
"To evaluate the comparative efficacy and safety of artemether-lumefantrine (AL), artesunate-amodiaquine (ASAQ) and artesunate-amodiaquine-chlorpheniramine (AQC) for the treatment of acute uncomplicated malaria among Southwest Nigerian children."5.19Evaluation of the comparative efficacy and safety of artemether-lumefantrine, artesunate-amodiaquine and artesunate-amodiaquine-chlorpheniramine (Artemoclo™) for the treatment of acute uncomplicated malaria in Nigerian children. ( Ademowo, OG; Dada-Adegbola, HO; Falade, CO; Nash, O; Oguike, MC; Ogunkunle, OO, 2014)
"Community health workers in Dangme-West district, Ghana, treated children aged 2-59 months with fever with either artesunate-amodiaquine (AAQ) or AAQ plus amoxicillin (AAQ + AMX) within a cluster-randomized controlled trial (registration no."5.17Impact of treating young children with antimalarials with or without antibiotics on morbidity: a cluster-randomized controlled trial in Ghana. ( Abbey, M; Adjuik, M; Chinbuah, MA; Cobelens, F; Gyapong, JO; Gyapong, M; Kager, PA; Koram, KA, 2013)
"6 mg/kg of amodiaquine per day) for the treatment of children and adults with uncomplicated falciparum malaria."5.16The efficacy and tolerability of artemisinin-piperaquine (Artequick®) versus artesunate-amodiaquine (Coarsucam™) for the treatment of uncomplicated Plasmodium falciparum malaria in south-central Vietnam. ( Chavchich, M; Dai, B; Edstein, MD; Phong, NC; Quang, HH; Shanks, GD; Thanh, NX; Trung, TN, 2012)
" A significantly higher proportion of children treated with artesunate-amodiaquine developed sinus bradycardia compared with artemether-lumefantrine treated subjects (7/47 vs 0/30; χ² p=0."5.16Electrocardiographic study in Ghanaian children with uncomplicated malaria, treated with artesunate-amodiaquine or artemether-lumefantrine. ( Adjei, GO; Alifrangis, M; Goka, BQ; Hoegberg, LC; Kurtzhals, JA; Oduro-Boatey, C; Rodrigues, OP, 2012)
"During the 2008 malaria transmission season, 1,277 children under five years of age resident in villages within the rural Farafenni demographic surveillance system (DSS) in North Bank Region, The Gambia were randomized to receive monthly IPTc with a single dose of sulphadoxine/pyrimethamine (SP) plus three doses of amodiaquine (AQ) or SP and AQ placebos given by village health workers (VHWs) on three occasions during the months of September, October and November, in a double-blind trial."5.15A trial of intermittent preventive treatment and home-based management of malaria in a rural area of The Gambia. ( Bojang, KA; Greenwood, BM; Milligan, P; Sesay, S; Sowe, M; Touray, E; Webb, EL, 2011)
" Three rounds of treatment with sulphadoxine pyrimethamine plus amodiaquine or placebos were given at monthly intervals during the malaria transmission season."5.15Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Burkina Faso: a randomised, double-blind, placebo-controlled trial. ( Chandramohan, D; Cousens, S; Diallo, DA; Diarra, A; Gansané, A; Greenwood, B; Kaboré, Y; Kangoyé, DT; Konaté, AT; Milligan, PJ; Ouédraogo, A; Ouédraogo, AZ; Ouédraogo, E; Ouédraogo, IN; Sirima, SB; Soulama, I; Tiono, AB; Yaro, JB, 2011)
"Sulphadoxine-pyrimethamine, in combination with artesunate or amodiaquine, is recommended for the treatment of uncomplicated malaria and is being evaluated for intermittent preventive treatment."5.15Effects of amodiaquine and artesunate on sulphadoxine-pyrimethamine pharmacokinetic parameters in children under five in Mali. ( Barnes, KI; Beavogui, AH; Djimde, AA; Doumbo, OK; Evans, A; Fredericks, A; Maiga, H; Sangare, CP; Smith, P; Tekete, MM; Toure, S; Traore, ZI, 2011)
"A cohort of 129 children aged 1-10 years in Kampala, Uganda, were treated with amodiaquine plus sulfadoxine-pyrimethamine for 396 episodes of uncomplicated malaria over a 29-month period as part of a longitudinal clinical trial."5.14Decreasing efficacy of antimalarial combination therapy in Uganda is explained by decreasing host immunity rather than increasing drug resistance. ( Clark, TD; Dorsey, G; Greenhouse, B; Hubbard, A; Kamya, MR; Maiteki-Sebuguzi, C; Njama-Meya, D; Nzarubara, B; Rosenthal, PJ; Slater, M; Staedke, SG, 2009)
"Pregnant women with non-severe, slide proven, falciparum malaria were randomised to one of 4 regimes: sulfadoxine-pyrimethamine [SP]; chlorproguanil-dapsone [CD]; SP+amodiaquine [SP+AQ] or amodiaquine+artesunate [AQ+AS]."5.14Randomized trial of artesunate+amodiaquine, sulfadoxine-pyrimethamine+amodiaquine, chlorproguanal-dapsone and SP for malaria in pregnancy in Tanzania. ( Briceño, M; Drakeley, C; Greenwood, BM; Mutabingwa, TK; Muze, K; Ord, R; Whitty, CJ, 2009)
"Pharmacokinetic (PK) data on amodiaquine (AQ) and artesunate (AS) are limited in children, an important risk group for malaria."5.14Population pharmacokinetics of artesunate and amodiaquine in African children. ( Gansané, A; Kiechel, JR; Morgan, CC; Ouedraogo, A; Ouedraogo, EB; Simpson, JA; Sirima, SB; Stepniewska, K; Taylor, W; White, NJ, 2009)
"Sulfadoxine-pyrimethamine with amodiaquine (SP-AQ) is a highly efficacious regimen for intermittent preventive treatment to prevent malaria in children (IPTc), but the amodiaquine component is not always well tolerated."5.14Amodiaquine dosage and tolerability for intermittent preventive treatment to prevent malaria in children. ( Ba, EH; Cairns, M; Cames, C; Cisse, B; Gaye, O; Greenwood, BM; Milligan, PJ; Simondon, K; Sokhna, C; Trape, JF, 2010)
" Children were randomized upon their first episode, and then treated for all episodes of uncomplicated malaria with amodiaquine/sulfadoxine-pyrimethamine (AQ/SP), artesunate/amodiaquine (AS/AQ), or artemether/lumefantrine (AL)."5.14Incidence of malaria and efficacy of combination antimalarial therapies over 4 years in an urban cohort of Ugandan children. ( Clark, TD; Dorsey, G; Greenhouse, B; Kamya, MR; Maiteki-Sebuguzi, C; Njama-Meya, D; Nzarubara, B; Rosenthal, PJ; Staedke, SG, 2010)
"Artesunate+amodiaquine (AS+AQ) and artemether-lumefantrine (AL) are now the most frequently recommended first line treatments for uncomplicated malaria in Africa."5.13An open label, randomised trial of artesunate+amodiaquine, artesunate+chlorproguanil-dapsone and artemether-lumefantrine for the treatment of uncomplicated malaria. ( Adjuik, M; Amenga-Etego, S; Asante, KP; Chandramohan, D; Dosoo, DK; Greenwood, B; Gyapong, J; Owusu, R; Owusu-Agyei, S, 2008)
"The in vivo therapeutic efficacy of the amodiaquine+sulfadoxine-pyrimethamine combination was evaluated in the treatment of uncomplicated Plasmodium falciparum malaria and of chloroquine for P."5.13[Efficacy of the amodiaquine+sulfadoxine-pyrimethamine combination and of chloroquine for the treatment of malaria in Córdoba, Colombia, 2006]. ( Cortés, LJ; Guerra, AP; Knudson, A; Nicholls, RS; Pérez, MA; Usta, C, 2008)
"Monthly artesunate plus amodiaquine reduced the incidence of malaria by 69% (95% CI: 63%, 74%) and anaemia by 45% (95% CI: 25%,60%), bimonthly sulphadoxine-pyrimethamine reduced the incidence of malaria by 24% (95% CI: 14%,33%) and anaemia by 30% (95% CI: 6%, 49%) and bimonthly artesunate plus amodiaquine reduced the incidence of malaria by 17% (95% CI: 6%, 27%) and anaemia by 32% (95% CI: 7%, 50%) compared to placebo."5.13Seasonal intermittent preventive treatment for the prevention of anaemia and malaria in Ghanaian children: a randomized, placebo controlled trial. ( Adjuik, M; Binka, F; Chandramohan, D; Greenwood, B; Kweku, M; Liu, D; Seidu, M, 2008)
"The Home Management of Malaria (HMM) strategy was developed using chloroquine, a now obsolete drug, which has been replaced by artemisinin-based combination therapy (ACT) in health facility settings."5.13Feasibility and acceptability of artemisinin-based combination therapy for the home management of malaria in four African sites. ( Agyei-Baffour, P; Ajayi, IO; Balyeku, A; Bateganya, F; Browne, EN; Cousens, S; Doamekpor, L; Garshong, B; Munguti, K; Pagnoni, F; Yusuf, B, 2008)
"Artesunate plus amodiaquine was highly efficacious for malaria treatment in HIV-infected children but was associated with a high risk of neutropenia, especially in the context of concurrent antiretroviral use."5.13High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda. ( Achan, J; Charlebois, E; Dorsey, G; Gasasira, AF; Havlir, D; Kalyango, JN; Kamya, MR; Kekitiinwa, A; Mebrahtu, T; Rosenthal, PJ; Ruel, T; Staedke, SG, 2008)
"We undertook a trial of artesunate + amodiaquine (AS + AQ) and artesunate + sulphadoxine-pyrimethamine (AS + SP) in 180 children of age 6-59 months with uncomplicated malaria in Democratic Republic of Congo."5.12Artesunate + amodiaquine and artesunate + sulphadoxine-pyrimethamine for treatment of uncomplicated malaria in Democratic Republic of Congo: a clinical trial with determination of sulphadoxine and pyrimethamine-resistant haplotypes. ( Kayembe, G; Montgomery, J; Pota, H; Roper, C; Swarthout, TD; van den Broek, IV, 2006)
" The high endemicity of malaria in Africa may impact on the efficacy of artemisinin-based combination therapy."5.11Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. ( Bakyaita, N; Banek, K; Dorsey, G; Kamya, MR; Kilian, A; Kironde, F; Nsobya, SL; Reingold, A; Rosenthal, PJ; Slater, M; Staedke, SG; Talisuna, A; Wabwire-Mangen, F; Yeka, A, 2005)
"To compare the efficacy and side-effects of two therapeutic regimens for chloroquine-resistant falciparum malaria, a randomized study was carried out in 69 patients in Maputo Central Hospital in 1986-1987."5.06[Comparative study of sulfadoxine-pyrimethamine and amodiaquine + sulfadoxine-pyrimethamine for the treatment of malaria caused by chloroquine-resistant Plasmodium falciparum in Maputo, Mozambique]. ( Dinis, DV; Schapira, A, 1990)
" Fifty cases of falciparum malaria were treated with 1800 mg amodiaquine for 3 days: the cure rate was 65."5.06Effectiveness of amodiaquine, sulfadoxine-pyrimethamine, and combinations of these drugs for treating chloroquine-resistant falciparum malaria in Hainan Island, China. ( Cai, XZ; Fu, SG; Huang, JK; Huang, OL; Ouyang, WC; Pang, XJ; Wang, XF; Wu, Z; Zhang, KY; Zhou, JX, 1988)
"The effects of chloroquine, amodiaquine and pyrimethamine-sulfadoxine (SP) (Fansidar) on the infection rate and density of Plasmodium falciparum gametocytes were studied in 198 patients with falciparum malaria from an area in the Punjab where malaria is endemic but seasonally transmitted."5.06Effects of chloroquine, amodiaquine and pyrimethamine-sulfadoxine on Plasmodium falciparum gametocytemia. ( Fox, E; Khaliq, AA; Macdonald, M; Sarwar, M; Strickland, GT, 1986)
"Amodiaquine was compared to chloroquine in two groups of Filipino patients with uncomplicated falciparum malaria."5.06Amodiaquine less effective than chloroquine in the treatment of falciparum malaria in the Philippines. ( Alban, P; Laughlin, LW; Long, GW; Padre, L; Ranoa, CP; Sangalang, R; Watt, G, 1987)
"Amodiaquine cured 38% (13/34) of patients with falciparum malaria in Southeast Thailand."5.04Amodiaquine resistant falciparum malaria in Thailand. ( Hall, AP; Kosakal, S; Pearlman, EJ; Phintuyothin, P; Segal, HE, 1975)
"The World Health Organization currently recommends quinine+clindamycin for use against malaria in the first trimester."4.95Animal Embryotoxicity Studies of Key Non-Artemisinin Antimalarials and Use in Women in the First Trimester. ( Clark, RL, 2017)
" Chemopreventive strategies have been increasingly deployed in Africa, notably intermittent sulfadoxine-pyrimethamine treatment in pregnancy, and monthly amodiaquine-sulfadoxine-pyrimethamine during the rainy season months in children aged between 3 months and 5 years across the sub-Sahel."4.90Malaria. ( Dondorp, AM; Faiz, MA; Hien, TT; Mokuolu, OA; Pukrittayakamee, S; White, NJ, 2014)
"To assess the relationship between the genetic and phenotypic factors linked to the cytochrome P-450 enzyme system and the response to the antimalarial drugs chloroquine, amodiaquine, mefloquine, and proguanil, as well as to determine how certain biological and social factors of the host influence the behavior of this enzymatic complex."4.83[Cytochrome P-450 and the response to antimalarial drugs]. ( Carmona-Fonseca, J; Guzmán, V, 2006)
"Several African countries have begun using amodiaquine-containing combinations as first-line antimalarial treatment, with the result that a substantial number of pregnant women are likely to be exposed to amodiaquine."4.82Can amodiaquine be used safely during pregnancy? ( D'Alessandro, U; Erhart, A; Thomas, F, 2004)
" These side effects include various mild heart rate changes (amodiaquine) to excessive prolongation of the QT interval (halofantrine) which may lead to lethal arrhythmias such as Torsade de Pointes (TdP)."4.82Antimalarial drugs: QT prolongation and cardiac arrhythmias. ( Dumotier, B; Traebert, M, 2005)
"Amodiaquine and chloroquine give fast relief from malaria symptoms, particularly fever."4.81Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria. ( McIntosh, HM, 2001)
"A meta-analysis study evaluating the efficacy and safety of chloroquine and alternative antimalarial drugs used in six African countries including Ethiopia, Kenya, Uganda, Cote D'Ivoire, Gambia and Nigeria is presented."4.80Comparative efficacy and safety of chloroquine and alternative antimalarial drugs: a meta-analysis from six African countries. ( Makonnen, E; Mengesha, T, 1999)
"Amodiaquine has been widely used to treat malaria."4.80Amodiaquine for treating malaria. ( Mussano, P; Olliaro, P, 2000)
"Amodiaquine and chloroquine give fast relief from malaria symptoms, particularly fever."4.80Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria. ( McIntosh, HM, 2000)
"Amodiaquine is a 4-aminoquinoline used extensively for the treatment and prevention of malaria."4.31Cardiovascular concentration-effect relationships of amodiaquine and its metabolite desethylamodiaquine: Clinical and preclinical studies. ( Burton, RB; Capel, RA; Chan, XHS; Chotsiri, P; Cremer, MA; Hanafiah, M; Hanboonkunupakarn, B; Kiechel, JR; Lee, SJ; Ogutu, B; Pike, J; Tarning, J; Taylor, WRJ; White, NJ; Win, YN, 2023)
"Between December, 2015, and March, 2016, and between December, 2017, and March, 2018, immediately following the 2015 and 2017 malaria transmission seasons, community surveys were done among children younger than 5 years and individuals aged 10-30 years in districts implementing seasonal malaria chemoprevention with sulfadoxine-pyrimethamine and amodiaquine in Burkina Faso, Chad, Guinea, Mali, Nigeria, Niger and The Gambia."4.31Prevalence of Plasmodium falciparum haplotypes associated with resistance to sulfadoxine-pyrimethamine and amodiaquine before and after upscaling of seasonal malaria chemoprevention in seven African countries: a genomic surveillance study. ( Bazie, T; Beshir, KB; Bojang, K; Cairns, M; Ceesay, S; Diallo, A; Dicko, A; Doumagoum, D; Eloike, T; Gamougam, K; Kessely, H; Kolie, F; Lamine, MM; Laminou, IM; Loua, K; Maiga, H; Mansukhani, R; Merle, CS; Milligan, P; Moroso, D; Muwanguzi, J; Nader, J; NDiaye, JL; Ogboi, SJ; Ouedraogo, JB; Razafindralambo, L; Sagara, I; Scott, S; Snell, P; Sutherland, CJ; Traore, A; Zongo, I, 2023)
"Despite scale-up of seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine and amodiaquine (SP-AQ) in children 3-59 months of age in Burkina Faso, malaria incidence remains high, raising concerns regarding SMC effectiveness and selection of drug resistance."4.31Seasonal Malaria Chemoprevention Drug Levels and Drug Resistance Markers in Children With or Without Malaria in Burkina Faso: A Case-Control Study. ( Aweeka, F; Conrad, MD; Haro, A; Huang, L; Legac, J; Ouédraogo, JB; Roh, ME; Rosenthal, PJ; Somé, AF; Wallender, E; Yerbanga, RS; Zongo, I, 2023)
"In a prospective longitudinal in vivo study, neutrophil rates were compared with malaria carriage after treatment with different ACTs: Artemether - lumefantrine (AL), Artesunate - amodiaquine (ASAQ), Dihydroartemisinin - piperaquine (DP) or Pyronaridine artesunate (PA)."4.31Variation in neutrophil levels and artemisinin-based combination therapy efficacy in West-Africa. ( Arama, C; Beavogui, AH; Dicko, A; Djimde, A; Djimde, M; Fofana, B; Kayentao, K; Mens, PF; Ouedraogo, JB; Sagara, I; Schallig, HD; Sirima, SB; Tshiongo, JK, 2023)
"Artesunate-amodiaquine (ASAQ) and Artemether-lumefantrine (AL) are the recommended treatment for uncomplicated Plasmodium falciparum malaria in Liberia."4.12Artesunate-amodiaquine and artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in Liberia: in vivo efficacy and frequency of molecular markers. ( Asinya, M; Jeuronlon, MK; Kamara, P; Koko, VS; Kollie, A; Ma, L; Menard, D; Nyansaiye, P; Parwon, S; Pratt, OJ; Ringwald, P; Taweh, F; Tehmeh, L; Vonhm, B; Warsame, M, 2022)
"Artesunate-amodiaquine is a potential therapy for uncomplicated malaria in Cambodia."4.02Clinical and In Vitro Resistance of Plasmodium falciparum to Artesunate-Amodiaquine in Cambodia. ( Ariey, F; Chy, S; Dorina Bustos, M; Eam, R; Izac, B; Kauy, C; Ke, S; Khim, N; Kim, S; Kloeung, N; Leang, R; Mairet-Khedim, M; Marmai, C; Mey Bouth, D; Ringwald, P; Witkowski, B, 2021)
"Based on reports of parasite resistance and on World Health Organization recommendation, chloroquine was replaced with the artemisinin-based combination therapies (ACTs) as the first choice of drugs for the treatment of uncomplicated malaria."4.02Treatment of COVID-19 with Chloroquine: Implication for Malaria Chemotherapy Using ACTs in Disease Endemic Countries. ( Duah-Quashie, NO; Quashie, NB, 2021)
" This study aimed to monitor the occurrence of adverse events (AEs) after the use of artemisinin-based combination therapies (ACTs), identify potential drivers of reporting suspected adverse drug reactions (ADRs) and monitor AEs among women who were inadvertently exposed to ACTs in the first trimester of pregnancy."3.96Optimal Approach and Strategies to Strengthen Pharmacovigilance in Sub-Saharan Africa: A Cohort Study of Patients Treated with First-Line Artemisinin-Based Combination Therapies in the Nanoro Health and Demographic Surveillance System, Burkina Faso. ( Bihoun, B; Derra, K; Kazienga, A; Nakanabo-Diallo, S; Pagnoni, F; Rouamba, E; Rouamba, T; Samadoulougou-Kirakoya, F; Sondo, P; Sorgho, H; Tarnagda, Z; Tinto, H; Valea, I, 2020)
"A tremendous level of success has been achieved since the introduction of chloroquine and the combination of amodiaquine and artemisinin for the treatment of both complicated and uncomplicated malaria infections in sub-Saharan Africa."3.96Clinical Probe of Cyp2C8*2 Mutants in a Malaria Hyperendemic Zone: Evidence from North-Central, Nigeria. ( Adeniyi, OM; Ajibaye, O; Aremu, OI; Asogwa, N; Babamale, OA; Fakayode, O; Fatoba, IM; Iyiola, OA; Omotesho, OB; Opeyemi, OA; Salawu, KM; Shittu, O, 2020)
" MRDT-positive children received artesunate-amodiaquine (ASAQ), while MRDT-negative children were treated based on the clinical diagnosis of non-malaria febrile illness."3.91Consequences of restricting antimalarial drugs to rapid diagnostic test-positive febrile children in south-west Nigeria. ( Ajayi, IO; Baba, E; Badejo, JA; Chandramohan, D; Dada-Adegbola, HO; Falade, CO; Funwei, RI; Hamade, P; Jegede, AS; Michael, OS; Ogunkunle, OO; Ojurongbe, OD; Orimadegun, AE; Ssekitooleko, J; Webster, J, 2019)
" Whether the addition of azithromycin to the monthly sulfadoxine-pyrimethamine plus amodiaquine used for seasonal malaria chemoprevention could reduce mortality and morbidity among African children was unclear."3.91Effect of Adding Azithromycin to Seasonal Malaria Chemoprevention. ( Barry, A; Cairns, M; Chandramohan, D; Coumare, S; Diarra, M; Dicko, A; Doumbo, O; Greenwood, B; Kuepfer, I; Milligan, P; Nikiema, F; Ouedraogo, JB; Sagara, I; Tapily, A; Thera, I; Tinto, H; Traore, A; Yerbanga, S; Zongo, I, 2019)
"We fit unadjusted and adjusted regression models to standardized patient-level data to estimate the risk ratio for death among patients with confirmed EVD who were prescribed artesunate-amodiaquine (artesunate-amodiaquine group), as compared with those who were prescribed artemether-lumefantrine (artemether-lumefantrine group) and those who were not prescribed any antimalarial drug (no-antimalarial group)."3.83Effect of Artesunate-Amodiaquine on Mortality Related to Ebola Virus Disease. ( Azman, AS; Azuma, P; Bocquin, A; Cabrol, JC; Cannas, A; Ciglenecki, I; de Smet, M; Gignoux, E; Job, D; Kurth, A; Logue, C; Massaquoi, M; Petrucci, R; Potet, J; Pottage, T; Serafini, M; Sterk, E; Strecker, T; Suzuki, M; Tiffany, A; Yue, C, 2016)
"Co-administration of amodiaquine with MAMA decoction (MD), an herbal antimalarial drug comprising the leaves of Mangifera indica L."3.83Evaluation of herbal antimalarial MAMA decoction-amodiaquine combination in murine malaria model. ( Adepiti, AO; Bolaji, OO; Elujoba, AA, 2016)
" The lower-dose combination of the leaf extract and amodiaquine had better antimalarial activity in CQ-sensitive murine malaria."3.83Evaluation of the combination of Uvaria chamae (P. Beauv.) and amodiaquine in murine malaria. ( Adepiti, AO; Iwalewa, EO, 2016)
" A pre-tested interviewer administered questionnaire was used to collect information on availability and use of malaria Rapid Diagnostic Test (mRDT) and artemisinin combination therapy (ACT), for management of uncomplicated malaria."3.83Adherence to malaria diagnosis and treatment guidelines among healthcare workers in Ogun State, Nigeria. ( Ajayi, I; Ajumobi, O; Bamiselu, OF; Dairo, D; Fawole, O; Oladimeji, A; Steven, Y, 2016)
"Faced with intense levels of chloroquine (CQ) resistance in Plasmodium falciparum malaria, Rwanda replaced CQ with amodiaquine (AQ)+sulfadoxine-pyrimethamine (SP) in 2001, and subsequently with artemether-lumefantrine (AL) in 2006, as first-line treatments for uncomplicated malaria."3.83Molecular surveillance of Plasmodium falciparum drug resistance markers reveals partial recovery of chloroquine susceptibility but sustained sulfadoxine-pyrimethamine resistance at two sites of different malaria transmission intensities in Rwanda. ( Grobusch, MP; Hakizimana, E; Kateera, F; Kumar, N; Mens, PF; Mutesa, L; Nsobya, SL; Tukwasibwe, S; van Vugt, M, 2016)
"A novel class of benzoheterocyclic analogues of amodiaquine designed to avoid toxic reactive metabolite formation was synthesized and evaluated for antiplasmodial activity against K1 (multidrug resistant) and NF54 (sensitive) strains of the malaria parasite Plasmodium falciparum."3.81Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies. ( Chibale, K; Egan, TJ; Jurva, U; Masimirembwa, CM; Njoroge, M; Ongarora, DS; Strydom, N; Wicht, K; Wiesner, L; Wittlin, S, 2015)
"42), showing antimalarial activity against drug-resistant and sensitive strains (EC50 values ∼ 3 μM), selectivity for malaria parasite and no cross-resistance with chloroquine, thus representing a potential new chemotype for further optimization towards novel and affordable antimalarial drugs."3.81Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype. ( Coelho, L; Lukens, AK; Mazitschek, R; Moreira, R; Nogueira, F; Paulo, A; Santos, SA; Wirth, DF, 2015)
" Thick smears stained with Giemsa were done for every febrile villager and malaria attacks were treated with combination of Artesunate plus Amodiaquine."3.81The implication of long-lasting insecticide-treated net use in the resurgence of malaria morbidity in a Senegal malaria endemic village in 2010-2011. ( Boyer, S; Diagne, N; Doucoure, S; Faye, N; Gaudart, J; Richard, V; Sokhna, C; Tall, A; Touré-Baldé, A; Trape, JF; Wotodjo, AN, 2015)
"Artesunate plus amodiaquine is used for malaria treatment in regions with overlapping HIV endemicity."3.80Disposition of amodiaquine and desethylamodiaquine in HIV-infected Nigerian subjects on nevirapine-containing antiretroviral therapy. ( Adedeji, WA; Adewole, IF; Akinola, IT; Akinyinka, OO; Aweeka, FT; Darin, KM; Fehintola, FA; Lindegardh, N; Ma, Q; Morse, GD; Murphy, RL; Ojengbede, O; Parikh, S; Scarsi, KK; Taiwo, B; Tarning, J, 2014)
" One example of such initiatives is the Fixed-Dose Artesunate Combination Therapy (FACT) project consortium, which brought together institutions with different natures from both the North and the South, for the development of two antimalarial fixed-dose combinations recommended by the WHO - artesunate-amodiaquine (ASAQ) and artesunate-mefloquine (ASMQ)."3.80Needs-driven versus market-driven pharmaceutical innovation: the consortium for the development of a new medicine against malaria in Brazil. ( Kameda, K, 2014)
" The anti-malarial activity of standard doses of amodiaquine (AQ) with or without artemether (ART) and combined with varying doses of rifampicin (RIF 15 mg/kg or RIF 30 mg/kg body weight) was evaluated in 40 mice sub-divided into eight groups and inoculated intraperitoneally with 1 × 10(7) red blood cells infected with chloroquine-resistant P."3.80Interaction between rifampicin, amodiaquine and artemether in mice infected with chloroquine resistant Plasmodium berghei. ( Abiodun, OO; Akinola, O; Badejo, JA; Gbotosho, GO; Happi, CT; Sowunmi, A, 2014)
"A pilot programme of Cohort Event Monitoring (CEM) was conducted across the six geopolitical zones of Nigeria on patients treated for uncomplicated malaria with artemisinin-based combination therapy (ACT)."3.79Safety of Artemisinin-Based Combination Therapies in Nigeria: A Cohort Event Monitoring Study. ( Adesina, O; Bassi, PU; Coulter, D; Isah, A; Jalo, I; Kalat, M; Nwoasu, SC; Nyong, EE; Osakwe, AI; Osungwu, F; Pal, S; Suku, C; Ugochukwu, C; Wallberg, M; Wammanda, RD, 2013)
"A case of an acute reversible visual loss in a 10-year-old child who was on mefloquine prophylaxis, and was treated with artesunate-amodiaquine for an acute febrile illness diagnosed clinically as uncomplicated malaria, is reported."3.78Reversible binocular visual loss in temporal association with artesunate-amodiaquine treatment in a child on mefloquine chemoprophylaxis. ( Adabayeri, VM; Adjei, GO; Annobil, SH, 2012)
"In 2002, DNDi created the FACT project to develop two fixed-dose combinations, artesunate-amodiaquine and artesunate-mefloquine, to meet the WHO anti-malarial treatment recommendations and international regulatory agencies approval standards."3.77Innovative public-private partnerships to maximize the delivery of anti-malarial medicines: lessons learned from the ASAQ Winthrop experience. ( Bompart, F; Kiechel, JR; Pecoul, B; Sebbag, R, 2011)
" First line anti-malarial was Amodiaquine plus sulphadoxine-pyrimethamine (AQ+SP) bi-therapy."3.77Management of uncomplicated malaria in children under 13 years of age at a district hospital in Senegal: from official guidelines to usual practices. ( Cissé, M; Lalou, R; Le Hesran, JY; Sarrassat, S, 2011)
"A study to measure adherence to artesunate and amodiaquine (AS+AQ) therapy in patients treated for uncomplicated malaria in community health centres (CHC) was conducted in Sierra Leone."3.76Successful introduction of artesunate combination therapy is not enough to fight malaria: results from an adherence study in Sierra Leone. ( Baker, S; Dunkley, S; Gerstl, S; Maikere, J; Mukhtar, A, 2010)
"One year after the adoption of artesunate-amodiaquine (AS/AQ) as first-line therapy for the treatment of uncomplicated malaria, this study was designed to assess the treatment practices regarding anti-malarial drugs at health facilities in four rural areas in southern Cameroon."3.75Treatment of malaria from monotherapy to artemisinin-based combination therapy by health professionals in rural health facilities in southern Cameroon. ( Bley, D; Gausseres, M; Malvy, D; Millet, P; Sayang, C; Vernazza-Licht, N, 2009)
"After adoption of artesunate-amodiaquine (AS/AQ) as first-line therapy for the treatment of uncomplicated malaria by the malaria control programme, this study was designed to assess the availability of anti-malarial drugs, treatment practices and acceptability of the new protocol by health professionals, in the urban health facilities and drugstores of Yaoundé city, Cameroon."3.75Treatment of malaria from monotherapy to artemisinin-based combination therapy by health professionals in urban health facilities in Yaoundé, central province, Cameroon. ( Bley, D; Gausseres, M; Malvy, D; Millet, P; Sayang, C; Vernazza-Licht, N, 2009)
" Different techniques used to measure compliance were compared among children treated by the anti-malarial amodiaquine/sulphadoxine-pyrimethamine (AQ/SP) combination therapy, in use in Senegal between 2004 and 2006."3.75Self-reported data: a major tool to assess compliance with anti-malarial combination therapy among children in Senegal. ( Carlotti, MP; Lalou, R; Le Hesran, JY; Moulin, P; Sarrassat, S; Souares, A, 2009)
"In 2003, artesunate-amodiaquine (AS+AQ) was introduced as the new first-line treatment for uncomplicated malaria in Burundi."3.74Community coverage of an antimalarial combination of artesunate and amodiaquine in Makamba Province, Burundi, nine months after its introduction. ( Brasher, C; Checchi, F; Cohuet, S; Edoh, K; Gerstl, S; Guthmann, JP; Lesage, A, 2007)
"In November 2001, the National Health Ministry of Rwanda advocated a new therapeutic protocol replacing chloroquine by an amodiaquine+sulfadoxine-pyrimethamine combination for the treatment of uncomplicated malaria."3.74[Assessing the application of Rwanda's national protocol for uncomplicated malaria treatment in healthcare institutions in Kigali City, Rwanda]. ( Freund, RJ; Lombrail, P; Malvy, D; Millet, P; Nzayirambaho, M; Potel, G, 2008)
"Between 1998 and 2001, Kenya, Uganda, Tanzania, Zanzibar, Rwanda and Burundi changed antimalarial drug policy, in the face of widespread chloroquine resistance."3.72The efficacy of antimalarial monotherapies, sulphadoxine-pyrimethamine and amodiaquine in East Africa: implications for sub-regional policy. ( , 2003)
"Amodiaquine (AQ) (2) is a 4-aminoquinoline antimalarial that can cause adverse side effects including agranulocytosis and liver damage."3.72Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials. ( Bickley, JF; Bray, PG; Hindley, S; Hughes, RH; Maggs, JL; Mukhtar, A; O'Neil, IA; O'Neill, PM; Park, BK; Randle, LE; Stocks, PA; Storr, RC; Ward, SA; Winstanley, PA, 2003)
"Amodiaquine (AQ) is an antimalarial which is effective against chloroquino-resistant strains of Plasmodium falciparum but whose clinical use is severely restricted because of associated hepatotoxicity and agranulocytosis."3.71"One-pot" synthesis and antimalarial activity of formamidine derivatives of 4-anilinoquinoline. ( Dali Ali, F; Delarue, S; Girault, S; Grellier, P; Maes, L; Sergheraert, C, 2001)
"The adverse reactions associated with the antimalarial amodiaquine (AQ), agranulocytosis and hepatotoxicity, have been attributed to the bioactivation of the drug to a quinone imine metabolite."3.69The effect of chemical substitution on the metabolic activation, metabolic detoxication, and pharmacological activity of amodiaquine in the mouse. ( Jewell, H; Maggs, JL; O'Neill, PM; Park, BK; Ruscoe, JE; Storr, RC; Ward, SA, 1995)
"The activities of Mannich base antimalarials, including pyronaridine, have been explored against drug-sensitive (Plasmodium berghei N) and chloroquine-resistant (Plasmodium yoelii NS) rodent malaria parasites in vivo."3.68The chemotherapy of rodent malaria. XLVII. Studies on pyronaridine and other Mannich base antimalarials. ( Peters, W; Robinson, BL, 1992)
"In view of the emergence of chloroquine resistant Plasmodium falciparum from more and more geographical areas profiling of the responses to other available antimalarials by in vitro methods have become essential."3.68An in-vitro profile of the action of four antimalarials on indigenous cases of Plasmodium falciparum malaria in Karnataka. ( Chakrabarti, NK; Nagaraj, C; Narasimham, MV, 1990)
"The authors evaluate the comparative efficiency of chloroquine and amodiaquine (35 mg/kg during 3 days) for uncomplicated malaria treatment in an area with high chemoresistance level."3.68[Uncomplicated malaria attack in an area with high chloroquine resistance. 2. Evaluation of first-choice therapeutic scheme]. ( Arrive, A; Eberlé, F; Gazin, P; Hengy, C; Jambou, R; Kouka-Bemba, D, 1990)
" falciparum to amodiaquine, quinine and quinidine was assessed in Tanga region where chloroquine resistance is established, to determine baseline susceptibility levels which could guide health care deliverers on the suitability of these drugs for the treatment of falciparum malaria in the areas studied."3.68The in vitro response of Plasmodium falciparum to amodiaquine, quinine and quinidine in Tanga region, Tanzania. ( Kilimali, VA, 1990)
" Oral amodiaquine (AQ) has been used to treat patients with symptomatic malaria in Zambia (n = 14) and Nigeria (n = 5)."3.68The disposition of amodiaquine in Zambians and Nigerians with malaria. ( Breckenridge, AM; Edwards, G; Kofi-Ekue, JM; Orme, ML; Salako, LA; Simooya, O; Walker, O; Winstanley, PA, 1990)
"An extended in vivo test of the sensitivity of Plasmodium falciparum to antimalarial drugs in Nigerian children showed no evidence of resistance to chloroquine and amodiaquine."3.67The sensitivity of Plasmodium falciparum to chloroquine and amodiaquine in Ibadan, Nigeria. ( Bademosi, K; Obih, PO; Salako, LA; Sodeinde, O; Walker, O, 1984)
"In the town of Edea, where falciparum malaria is hyperendemic, an in vivo study of amodiaquine sensitivity of the local strain of the parasite is performed in school children 6 to 12 years of age: 184 children with parasites in their blood and no chloroquine in their urine are given amodiaquine orally."3.67[In vivo sensitivity of Plasmodium falciparum to amodiaquine in the town of Edea (Cameroon)]. ( Combe, A; Eboumbou, J; Garnier, T; Macaigne, F; Michel, R; Ripert, C; Vincendeau, P, 1989)
"In eastern Thailand, 14 adults with moderately severe falciparum malaria were treated with intravenous amodiaquine dihydrochloride, loading dose 10 mg base/kg infused over 4 h followed by three further intravenous infusions of 5 mg base/kg at 24, 48, and 72 h."3.67Intravenous amodiaquine and oral amodiaquine/erythromycin in the treatment of chloroquine-resistant falciparum malaria. ( Attanath, P; Benjasurat, Y; Karbwang, J; Looareesuwan, S; Phillips, RE; Warrell, DA; White, NJ, 1985)
"6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken cotrimoxazole and another had taken sulphaguanidine."3.67Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria. ( Bunch, C; Edwards, G; Hatton, CS; Pasvol, G; Peto, TE; Russell, SJ; Singer, CR; Winstanley, P, 1986)
"Seven patients developed hepatitis after receiving amodiaquine for malaria prophylaxis for 4 to 15 weeks."3.67Amodiaquine-induced hepatitis. A report of seven cases. ( Benhamou, JP; Castot, A; Feldmann, G; Larrey, D; Lenoir, A; Machayekhy, JP; Merigot, P; Pëssayre, D; Rueff, B, 1986)
"This report describes two patients who developed agranulocytosis while receiving prophylactic amodiaquine treatment."3.67Amodiaquine-induced immune agranulocytosis. ( Abel, L; Aymard, JP; Chau, F; Coulombel, L; Rouveix, B, 1989)
"Seven cases of agranulocytosis and two of liver damage that were probably due to amodiaquine treatment were studied."3.67Amodiaquine induced agranulocytosis and liver damage. ( Fehr, J; Frick, PG; Neftel, KA; Schmid, M; Woodtly, W, 1986)
"Since August 1983, several cases of chloroquine resistant malaria have been observed in caucasian adults living in the Central African Republic (CAR) despite an antimalarial prophylaxis."3.67[Status of drug resistance of Plasmodium falciparum in the Central African Republic. Results of studies carried out between 1984 and 1986]. ( Delmont, J; Faugère, B; Georges, AJ; Limbassa, J; Monges, P; Testa, J, 1987)
"We present two cases of Plasmodium falciparum malaria contracted in Douala despite adequate prophylaxis by Fansidar for one and by chloroquine for the other."3.67[2 cases of multiresistant Plasmodium falciparum malaria contracted in Douala with atypical clinical presentation]. ( Charmot, G; Le Bras, J; Simon, F, 1987)
"24 cases of Plasmodium falciparum malaria in a group of 73 non-immune subjects coming mostly from central Africa have been tested in vitro for chloroquine sensitivity: 5 are sensitive, 19 are resistant among whom one is also quinine-resistant."3.67[Current aspects of imported drug-resistant Plasmodium falciparum]. ( Buisson, Y; Chabiersky, M; Daly, JP; Le Bras, J; Roué, R; Saliou, P; Simon, F; Talarmin, F, 1987)
"We evaluated amodiaquine as a replacement drug for treating falciparum malaria in an area of Pakistani Punjab where chloroquine-resistant Plasmodium falciparum has recently emerged."3.67Amodiaquine fails to cure chloroquine resistant Plasmodium falciparum in the Punjab. ( Fox, E; Khaliq, AA; Sarwar, M; Strickland, GT, 1987)
"Three patients suffered from fulminant hepatitis within 23, 59 and 22 weeks after having ingested a total dose of 16, 26 and 15 g, respectively, of amodiaquine for the prophylaxis of malaria."3.67Amodiaquine-induced fulminant hepatitis. ( Benhamou, JP; Bernuau, J; Campillo, B; Degott, C; Larrey, D; Pessayre, D; Rueff, B; Verdier, F, 1988)
"A death from chloroquinoresistant falciparum malaria contracted by a traveller under chloroquine chemoprophylaxis during a stay in the Cameroon provides the authors with an opportunity to analyze the extension of chloroquinoresistance in Africa."3.67[A fatal case of chloroquine-resistant neuromalaria in a traveller to Cameroon]. ( Beylot, J; Combe, A; Le Bras, J; Le Bras, M; Raccurt, CP; Ripert, C, 1986)
"Bone-marrow culture in soft agar was used to determine the cause of neutropenia in a visitor to Tanzania who had been taking both amodiaquine and proguanil for antimalarial prophylaxis."3.67Neutropenia associated with dual antimalarial chemoprophylaxis--use of bone-marrow culture as an aid in further drug management. ( Addison, GM; Ellis, ME; Steed, AJ, 1987)
"Two patients are presented who during malaria prophylaxis with amodiaquine developed a hepatitis associated with granulocytopenia of short duration."3.67[Amodiaquine-induced hepatitis with leukopenia]. ( Siegrist, P; Vonmoos, P; Woodtli, W; Zollikofer, H, 1986)
"Amodiaquine hydrochloride (3 mg base kg-1) was given by constant rate intravenous injection over 10 min to seven healthy adult male volunteers, and by constant rate infusion (10 mg base kg-1) over 4 h to 10 adult patients admitted to hospital with falciparum malaria."3.67Pharmacokinetics of intravenous amodiaquine. ( Bunch, C; Edwards, G; Karbwang, J; Looareesuwan, S; Nicholl, DD; Phillips, RE; Warrell, DA; White, NJ, 1987)
"A village-based programme of presumptive treatment of fever, using voluntary village aides to dispense oral chloroquine or amodiaquine, was established in 1982 by the Papua New Guinea Institute of Medical Research (PNG IMR) in 35 rural villages or hamlets near Madang, on the north coast of PNG."3.67The role of voluntary village aides in the control of malaria by presumptive treatment of fever. 2. Impact on village health. ( Alpers, MP; Heywood, PF; Jolley, DJ; Moir, JS; Tulloch, JL; Vrbova, H, 1985)
"One hundred cases of slide-confirmed Plasmodium falciparum malaria admitted to the San Lazaro Hospital, Manila, Philippines were screened for in vitro resistance to chloroquine, quinine, amodiaquine and mefloquine using the microtechnique."3.67Studies of resistance to chloroquine, quinine, amodiaquine and mefloquine among Philippine strains of Plasmodium falciparum. ( Alcantara, AK; Buck, RL; Rodriguez, CS; Smrkovski, LL; Uylangco, CV, 1985)
"The sensitivity level of Plasmodium falciparum isolates to chloroquine and the activity of six other antimalarials were studied in the different climatic zones of Madagascar in 1983."3.67Plasmodium falciparum in Madagascar: in vivo and in vitro sensitivity to seven drugs. ( Coulanges, P; Deloron, P; Le Bras, J; Ramanamirija, JA, 1985)
"The authors have devised a specific HPLC method for amodiaquine assay which demonstrated that the drug disappeared rapidly from the blood of subjects under prophylaxis for malaria (10 mg/kg/week in a single oral dose)."3.67[Biotransformation of amiodaquine and prophylaxis of Plasmodium falciparum malaria]. ( Blayo, MC; Pocidalo, JJ; Pussard, E; Verdier, F, 1985)
"We report a patient who developed agranulocytosis following exposure to three drugs: amodiaquine, pyrimethamine and dipyrone."3.67Amodiaquine-induced agranulocytosis: drug inhibition of myeloid colonies in the presence of patient's serum. ( Douer, D; Ramot, B; Schwartz, E; Shaked, N, 1985)
"A combination of the drugs amodiaquine and tetracycline was used in a clinical trial at Phrabuddhabat Hospital in Central Thailand for treating Plasmodium falciparum malaria."3.66Treatment of Plasmodium falciparum malaria with a combination of amodiaquine and tetracycline in Central Thailand. ( Benjapong, W; Duriyananda, D; Malikul, S; Noeypatimanond, S; Ungkasrithongkul, M, 1983)
"A patient is presented who developed agranulocytosis while taking amodiaquine for suppressive therapy of malaria."3.66[Amodiaquine-induced agranulocytosis in malaria prevention: demonstration of an amodiaquine-induced cytotoxic antibody against granulocytes]. ( Gmür, J; Neftel, K; Schulthess, HK; von Felten, A, 1983)
"Evidence of resistance ot chloroquine was found in 13 out of 14 children from the East New Britain Province of Papua New Guinea, with Plasmodium falciparum malaria."3.66Chloroquine resistant Plasmodium falciparum malaria in East New Britain, Papua New Guinea. ( Tulloch, A, 1980)
"Chloroquine and amodiaquine are demonstrably still the most reliable drugs for the treatment of malaria, except in the south east Asia area, and in parts of south and central America where an altered sensitivity of falciparum plasmodia has been confirmed."3.65[Chemotherapy and chemoprophylaxis of malaria (author's transl)]. ( Bruce-Chwatt, LJ, 1976)
" Eleven volunteers received chloroquine in usually curative doses on a three-day schedule during acute clinical malaria attacks."3.64STUDIES ON A STRAIN OF CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM FROM THAILAND. ( ALVING, AS; BREWER, GJ; MILLAR, JW; POWELL, RD, 1964)
"Intermittent preventive treatment of malaria among schoolchildren (IPTsc) reduces clinical malaria, asymptomatic parasitemia, and anemia."3.11Overall and Gender-Specific Effects of Intermittent Preventive Treatment of Malaria with Artemisinin-Based Combination Therapies among Schoolchildren in Mali: A Three-Group Open Label Randomized Controlled Trial. ( Bamadio, A; Chico, RM; Cohee, LM; Coumare, S; Dara, A; Diarra, M; Djimde, AA; Doumbo, OK; Kodio, A; Maiga, H; Opondo, C; Sagara, I; Sidibe, B; Tekete, M; Traore, OB; Traore, ZI, 2022)
"Children with sickle cell anemia (SCA) in areas of Africa with endemic malaria transmission are commonly prescribed malaria chemoprevention."3.11Monthly sulfadoxine/pyrimethamine-amodiaquine or dihydroartemisinin-piperaquine as malaria chemoprevention in young Kenyan children with sickle cell anemia: A randomized controlled trial. ( Clapp, S; Freedman, B; Green, CL; Kirui, JK; Korwa, S; Njuguna, FM; O'Meara, WP; Taylor, SM; Wu, A, 2022)
" Understanding the safety, pharmacokinetic and pharmacodynamic properties of antimalarial combination therapies is crucial in optimising dosing."2.82Pharmacokinetic considerations in seasonal malaria chemoprevention. ( Chotsiri, P; Tarning, J; White, NJ, 2022)
" CF fortified with highly bioavailable iron improved iron status but not Hb concentration, despite three-monthly IPT of malaria."2.80The effect of iron-fortified complementary food and intermittent preventive treatment of malaria on anaemia in 12- to 36-month-old children: a cluster-randomised controlled trial. ( Adiossan, LG; Brittenham, GM; Diakité, VG; Glinz, D; Hurrell, RF; N'Goran, EK; Ouattara, M; Righetti, AA; Seifert, B; Utzinger, J; Wegmüller, R; Zimmermann, MB, 2015)
"Malaria and pneumonia are leading causes of childhood mortality."2.77Impact of community management of fever (using antimalarials with or without antibiotics) on childhood mortality: a cluster-randomized controlled trial in Ghana. ( Abbey, M; Adjuik, M; Aikins, M; Awini, E; Chinbuah, MA; Gyapong, JO; Gyapong, M; Kager, PA; Nonvignon, J; Pagnoni, F, 2012)
"Intermittent preventive treatment for malaria in children (IPTc) involves the administration of a full course of an anti-malarial treatment to children under 5 years old at specified time points regardless of whether or not they are known to be infected, in areas where malaria transmission is seasonal."2.75Cost effectiveness of seasonal intermittent preventive treatment using amodiaquine & artesunate or sulphadoxine-pyrimethamine in Ghanaian children. ( Chandramohan, D; Conteh, L; Greenwood, B; Kweku, M; Legood, R; Patouillard, E, 2010)
"1) of program and control retailers, respectively, reported correct knowledge on dosing with amodiaquine (OR = 29."2.74Impact of ministry of health interventions on private medicine retailer knowledge and practices on anti-malarial treatment in Kenya. ( Abuya, T; Fegan, G; Karisa, B; Marsh, V; Mutemi, W; Ochola, S; Rowa, Y, 2009)
" Secondary end-points were incidence of adverse events, mean haemoglobin concentration and prevalence of parasites carrying markers of resistance to SP."2.73A trial of the efficacy, safety and impact on drug resistance of four drug regimens for seasonal intermittent preventive treatment for malaria in Senegalese children. ( Bâ, el H; Boulanger, D; Cissé, B; Gaye, O; Greenwood, B; Hallett, R; Lines, J; Milligan, P; Simondon, F; Simondon, K; Sokhna, C; Sutherland, C; Targett, G; Trape, JF, 2008)
" Additionally, these models are able to identify patient characteristics that cause alterations in the expected PK/PD profiles and through simulations can recommend changes to dosing which compensate for the differences."2.72Malaria PK/PD and the Role Pharmacometrics Can Play in the Global Health Arena: Malaria Treatment Regimens for Vulnerable Populations. ( Hughes, E; Jagannathan, P; Mohamed Ali, A; Savic, RM; Wallender, E, 2021)
"Acute malaria has been associated with a decreased antibody response to tetanus and diphtheria toxoids, meningococcal, salmonella, and Hib vaccines."2.71Malaria chemoprophylaxis and the serologic response to measles and diphtheria-tetanus-whole-cell pertussis vaccines. ( Breman, JG; Campaoré, P; Collins, WE; Lobel, HO; Manclark, CR; Meade, BD; Miller, MA; Roberts, JM; Rosen, JB; Saliou, P, 2005)
"The present monograph reviews data relevant to applying the biowaiver procedure for the approval of immediate release (IR) multisource solid dosage forms containing amodiaquine hydrochloride (ADQ) as the single active pharmaceutical ingredient (API)."2.48Biowaiver monographs for immediate release solid oral dosage forms: amodiaquine hydrochloride. ( Abrahamsson, B; Barends, DM; Dressman, JB; Groot, DW; Kopp, S; Nair, A; Polli, JE; Shah, VP, 2012)
" Safe and effective drugs, capable of being administered as a single-dose or short-course treatment, are urgently needed to control the adaptable malaria parasite."2.36Falciparum malaria: the urgent need for safe and effective drugs. ( Rieckmann, KH, 1983)
"Malaria is not a disease of the past."2.36[Current information on treatment and prophylaxis of malaria (author's transl)]. ( Cambournac, FJ, 1979)
"Malaria is the leading cause of morbidity and mortality among infants and children under-five in sub-Saharan Africa."1.91Predictors of caregiver adherence to administration of amodiaquine during delivery of seasonal malaria chemoprevention in Nigeria, Burkina Faso, Chad, and Togo. ( Aidenagbon, A; Ibinaiye, T; Ogunmola, O; Oguoma, C; Oresanya, O; Rassi, C; Richardson, S, 2023)
"Malaria is the one of the deadliest infectious diseases worldwide."1.91Antimalarial Agents Derived from Metal-Amodiaquine Complexes with Activity in Multiple Stages of the Plasmodium Life Cycle. ( Araújo Nobrega, J; Azevedo Batista, A; Basilico, N; Colina-Vegas, L; D'Alessandro, S; da Cruz B Silva, M; de Souza Pereira, C; Isis Barros, A; Moreira, DRM; Navarro, M; Rottmann, M, 2023)
"Under-five malaria data for confirmed episodes, deaths, and number of children dosed per cycle of SMC campaign were extracted from the District Health Information Management System (DHIMS-2) for 2018-2019."1.72Effectiveness of seasonal malaria chemoprevention in reducing under-five malaria morbidity and mortality in the Savannah Region, Ghana. ( Abubakari, II; Adjei, MR; Baafi, JV; Buamah, M; Ibrahim, S; Kubio, C; Sadiq, A; Sarfo, A; Suuri, T, 2022)
" The present study hence evaluated the effect of MD on the disposition of AQ in mice with a view to investigating a possible pharmacokinetic interaction."1.56Influence of MAMA decoction, an Herbal Antimalarial, on the Pharmacokinetics of Amodiaquine in Mice. ( Adeagbo, BA; Adehin, A; Adepiti, AO; Bolaji, OO; Elujoba, AA, 2020)
" Here, we evaluated the population pharmacokinetic properties of amodiaquine and its active metabolite, desethylamodiaquine, in children receiving SMC under directly observed ideal conditions (n = 136), and the adherence of SMC at an implementation phase in children participating in a case-control study to evaluate SMC effectiveness (n = 869)."1.56Adherence and Population Pharmacokinetic Properties of Amodiaquine When Used for Seasonal Malaria Chemoprevention in African Children. ( Assao, B; Blessborn, D; Coldiron, ME; Ding, J; Grais, RF; Guindo, O; Koscalova, A; Langendorf, C; Tarning, J; Winterberg, M, 2020)
" Thus, the efficacy of ASAQ is maintained and appears to be increased after long-term use in contrast to what is observed for other ACTs used in Africa."1.56Increased Sensitivity of Plasmodium falciparum to Artesunate/Amodiaquine Despite 14 Years as First-Line Malaria Treatment, Zanzibar. ( Abbas, FB; Ali, AS; Ali, AW; Barnes, R; Björkman, A; Frumento, P; Mårtensson, A; Morris, U; Msellem, M; Soe, A, 2020)
"There was no evidence of proarrhythmia with any treatment during the study although dihydroartemisinin-piperaquine, artesunate-amodiaquine and artemether-lumefantrine significantly prolonged QTc."1.51Evaluation of the effects on the QT-interval of 4 artemisinin-based combination therapies with a correction-free and heart rate-free method. ( Beavogui, AH; Borghini-Fuhrer, I; Djimdé, AA; Duparc, S; Felices, M; Funck-Brentano, C; Khan, Y; Ouedraogo, JB; Ouologuem, N; Sagara, I; Sirima, SB; Soulama, I; Voiriot, P, 2019)
"Different approaches are adopted when treating malaria."1.43Seeking treatment for uncomplicated malaria: experiences from the Kintampo districts of Ghana. ( Abokyi, LN; Afari-Asiedu, S; Asante, KP; Febir, LG; Gyapong, M; Kwarteng, A; Ogutu, B; Owusu-Agyei, S, 2016)
" The occurrence and severity of events was collected before, during and after treatment up to 28 days in order to generate information on all adverse events (AEs) as well as treatment-emerging signs/symptoms (TESS)."1.38Anti-malarial drug safety information obtained through routine monitoring in a rural district of South-Western Senegal. ( Brasseur, P; Olliaro, PL; Vaillant, MT, 2012)
" The orally bioavailable lead imidazolopiperazine confers complete causal prophylactic protection (15 milligrams/kilogram) in rodent models of malaria and shows potent in vivo blood-stage therapeutic activity."1.37Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. ( Barnes, SW; Bonamy, GM; Bopp, SE; Borboa, R; Bright, AT; Chatterjee, A; Che, J; Cohen, S; Dharia, NV; Diagana, TT; Fidock, DA; Froissard, P; Gagaring, K; Gettayacamin, M; Glynne, RJ; Gordon, P; Groessl, T; Kato, N; Kuhen, KL; Lee, MC; Mazier, D; McNamara, CW; Meister, S; Nagle, A; Nam, TG; Plouffe, DM; Richmond, W; Roland, J; Rottmann, M; Sattabongkot, J; Schultz, PG; Tuntland, T; Walker, JR; Winzeler, EA; Wu, T; Zhou, B; Zhou, Y, 2011)
" Intermittent preventive treatment for children (IPTc) combined with timely treatment of malaria related febrile illness at home to reduce parasite prevalence and malaria morbidity in children aged between six and 60 months in a coastal community in Ghana."1.37Two-year evaluation of Intermittent Preventive Treatment for Children (IPTc) combined with timely home treatment for malaria control in Ghana. ( Ahorlu, CK; Koram, KA; Seake-Kwawu, A; Weiss, MG, 2011)
"Malaria is reportedly receding in different epidemiological settings, but local long-term surveys are limited."1.37Changing patterns of malaria during 1996-2010 in an area of moderate transmission in southern Senegal. ( Agnamey, P; Badiane, M; Brasseur, P; Cisse, M; Olliaro, PL; Vaillant, MT, 2011)
"malariae is correlated with increased P."1.35Increased Plasmodium falciparum gametocyte production in mixed infections with P. malariae. ( Arens, T; Bousema, JT; Drakeley, CJ; Gouagna, LC; Houben, R; Mens, PF; Omar, SA; Sauerwein, RW; Schallig, H, 2008)
"Amodiaquine is an amino-4-quinoline with the basic spectrum of activity of chloroquine."1.34Emergency liver transplantation in amodiaquine-induced fulminant hepatitis. ( Desmeules, J; Giostra, E; Hadengue, A; Markham, LN; Rebsamen, M; Rossier, M, 2007)
" The assay of amodiaquine hydrochloride in pharmaceutical dosage forms using one of the proposed sensors gave average recoveries of 104."1.33Amodiaquine polymeric membrane electrode. ( Amighi, K; Blankert, B; Kambu, O; Kauffmann, JM; Malongo, TK; Nsangu, J, 2006)
" The results indicate the suitability of this technique in antimalarial drug quality and bioavailability studies."1.33A simple technique for the detection of anti-malarial drug formulations and their presence in human urine. ( Akida, JA; Lemnge, MM; Lugimbana, L; Malebo, HM; Malle, LN; Segeja, MD, 2006)
" A 25-mg base/kg dosage of amodiaquine produced parasite clearance in 34 of 38 (89%) children in a mean of 2."1.27Evaluation of amodiaquine treatment of chloroquine-resistant Plasmodium falciparum malaria on Zanzibar, 1982. ( Campbell, CC; Khatib, OJ; Payne, D; Schwartz, IK, 1983)
" Reappraisal of quinine therapy has led to important modifications in dosage recommendations and recognition of a major complication of severe malaria associated with its use--hypoglycaemia."1.27Management of Plasmodium falciparum malaria. ( Phillips, RE, 1984)
"Chloroquine resistance was confirmed by testing in vitro and in vivo."1.27Multiple drug resistant Plasmodium falciparum malaria in a pregnant indigenous Zambian woman. ( Rolfe, M, 1988)
"Amodiaquine was not found in any sample, but the major metabolite monodesethylamodiaquine was detected and was assumed to be the sole derivative that contributed significantly to antimalarial activity in the blood."1.27Disposition of monodesethylamodiaquine after a single oral dose of amodiaquine and three regimens for prophylaxis against Plasmodium falciparum malaria. ( Blayo, MC; Faurisson, F; Le Bras, J; Pussard, E; Scherrmann, JM; Verdier, F, 1987)
"Amodiaquine was associated with a 3."1.27Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis. ( Gyr, N; Schär, M; Stürchler, D, 1987)
"Malaria is the only significant cause of ahaptoglobinaemia in subjects both with and without detectable parasitaemia."1.27Malaria, cause of ahaptoglobinaemia in Africans. ( Bosseno, MF; Engler, R; Fribourg-Blanc, A; Lallemant, M; Mouchet, J; Trape, JF, 1985)
" In an attempt to explain the discrepancy between its in vivo-in vitro activity, a pharmacokinetic study was conducted in healthy subjects with HPLC assays."1.27[Pharmacokinetics of amodiaquine and prevention of Plasmodium falciparum malaria]. ( Blayo, MC; Faurisson, F; Pussard, E; Verdier, F, 1985)

Research

Studies (421)

TimeframeStudies, this research(%)All Research%
pre-1990201 (47.74)18.7374
1990's22 (5.23)18.2507
2000's71 (16.86)29.6817
2010's81 (19.24)24.3611
2020's46 (10.93)2.80

Authors

AuthorsStudies
Meister, S1
Plouffe, DM1
Kuhen, KL1
Bonamy, GM1
Wu, T1
Barnes, SW1
Bopp, SE1
Borboa, R1
Bright, AT1
Che, J1
Cohen, S1
Dharia, NV1
Gagaring, K1
Gettayacamin, M1
Gordon, P1
Groessl, T1
Kato, N1
Lee, MC2
McNamara, CW1
Fidock, DA2
Nagle, A1
Nam, TG1
Richmond, W1
Roland, J1
Rottmann, M3
Zhou, B1
Froissard, P1
Glynne, RJ1
Mazier, D2
Sattabongkot, J1
Schultz, PG1
Tuntland, T1
Walker, JR1
Zhou, Y1
Chatterjee, A1
Diagana, TT1
Winzeler, EA1
Cross, RM1
Flanigan, DL1
Monastyrskyi, A2
LaCrue, AN2
Sáenz, FE1
Maignan, JR2
Mutka, TS1
White, KL1
Shackleford, DM1
Bathurst, I1
Fronczek, FR1
Wojtas, L1
Guida, WC1
Charman, SA1
Burrows, JN1
Kyle, DE2
Manetsch, R2
Ongarora, DS1
Strydom, N1
Wicht, K1
Njoroge, M1
Wiesner, L1
Egan, TJ1
Wittlin, S3
Jurva, U1
Masimirembwa, CM1
Chibale, K1
Santos, SA1
Lukens, AK1
Coelho, L1
Nogueira, F1
Wirth, DF1
Mazitschek, R1
Moreira, R1
Paulo, A1
da Silva, RMRJ1
Gandi, MO1
Mendonça, JS1
Carvalho, AS1
Coutinho, JP1
Aguiar, ACC1
Krettli, AU1
Boechat, N1
Tibon, NS1
Ng, CH1
Cheong, SL1
Brockmeyer, F1
Zhao, Y1
Maher, SP1
Padin-Irizarry, V1
Sakhno, YI1
Parvatkar, PT1
Asakawa, AH1
Huang, L2
Casandra, D1
Mashkouri, S1
Abuaku, B3
Duah-Quashie, NO2
Quashie, N2
Gyasi, A1
Afriyie, PO1
Owusu-Antwi, F1
Ghansah, A3
Malm, KL1
Bart-Plange, C2
Koram, KA6
Mahamar, A2
Sumner, KM1
Levitt, B1
Freedman, B2
Traore, A3
Barry, A2
Issiaka, D1
Dembele, AB1
Kanoute, MB1
Attaher, O1
Diarra, BN1
Sagara, I9
Djimde, A2
Duffy, PE1
Fried, M1
Taylor, SM2
Dicko, A7
Marwa, K1
Kapesa, A1
Baraka, V2
Konje, E1
Kidenya, B1
Mukonzo, J1
Kamugisha, E1
Swedberg, G1
Peto, TJ1
Tripura, R1
Callery, JJ1
Lek, D1
Nghia, HDT1
Nguon, C1
Thuong, NTH1
van der Pluijm, RW1
Dung, NTP1
Sokha, M1
Van Luong, V1
Long, LT1
Sovann, Y1
Duanguppama, J1
Waithira, N1
Hoglund, RM1
Chotsiri, P3
Chau, NH1
Ruecker, A1
Amaratunga, C1
Dhorda, M1
Miotto, O1
Maude, RJ1
Rekol, H1
Chotivanich, K1
Tarning, J7
von Seidlein, L2
Imwong, M1
Mukaka, M1
Day, NPJ1
Hien, TT2
White, NJ9
Dondorp, AM2
Koko, VS1
Warsame, M2
Vonhm, B1
Jeuronlon, MK1
Menard, D2
Ma, L1
Taweh, F1
Tehmeh, L1
Nyansaiye, P1
Pratt, OJ1
Parwon, S1
Kamara, P1
Asinya, M1
Kollie, A1
Ringwald, P3
Pembet Singana, B1
Casimiro, PN1
Matondo Diassivi, B1
Kobawila, SC1
Youndouka, JM1
Basco, LK1
Briolant, S1
Ndounga, M4
Hien, D2
Kaboré, JMT2
Siribié, M2
Soulama, I4
Barry, N3
Baguiya, A2
Tiono, AB3
Tchouatieu, AM2
Sirima, SB6
Maiga, H3
Opondo, C1
Chico, RM1
Cohee, LM1
Traore, OB1
Tekete, M1
Dara, A1
Traore, ZI2
Diarra, M2
Coumare, S2
Kodio, A1
Bamadio, A1
Sidibe, B2
Doumbo, OK3
Djimde, AA5
Korwa, S1
Wu, A1
Green, CL1
Clapp, S1
Kirui, JK1
O'Meara, WP1
Njuguna, FM1
Doumbia, S1
Sogoba, N1
Diakite, M1
Toure, M1
Keita, M1
Konaté, D1
Diawara, SI1
Diarra, A2
Sanogo, D1
Kane, F1
Diakite, SAS1
Traore, K1
Thiam, SM1
Traoré, SF1
Cisse, I1
Mihigo, J3
Coulibaly, MB1
Dabitao, D1
Alifrangis, M2
Barry, AE1
Müller, GC1
Beier, JC1
Shaffer, JG1
Chan, XHS1
Capel, RA1
Pike, J1
Hanboonkunupakarn, B1
Lee, SJ1
Hanafiah, M1
Win, YN1
Cremer, MA1
Kiechel, JR7
Ogutu, B2
Taylor, WRJ1
Burton, RB1
Zoleko-Manego, R1
Okwu, DG1
Handrich, C1
Dimessa-Mbadinga, LB1
Akinosho, MA1
Ndzebe-Ndoumba, WF1
Davi, SD1
Stelzl, D1
Veletzky, L1
Kreidenweiss, A1
Nordmann, T1
Adegnika, AA1
Lell, B2
Kremsner, PG4
Ramharter, M1
Mombo-Ngoma, G1
Beshir, KB1
Muwanguzi, J1
Nader, J1
Mansukhani, R1
Gamougam, K1
Ceesay, S2
Bazie, T1
Kolie, F1
Lamine, MM1
Cairns, M8
Snell, P1
Scott, S1
Diallo, A1
Merle, CS1
NDiaye, JL4
Razafindralambo, L1
Moroso, D1
Ouedraogo, JB8
Zongo, I6
Kessely, H1
Doumagoum, D1
Bojang, K1
Loua, K1
Laminou, IM1
Ogboi, SJ1
Eloike, T1
Milligan, P6
Sutherland, CJ1
Nuwa, A1
Baker, K1
Bonnington, C1
Odongo, M1
Kyagulanyi, T1
Bwanika, JB1
Richardson, S2
Nabakooza, J1
Achan, J2
Kajubi, R1
Odong, DS1
Nakirunda, M1
Magumba, G1
Beinomugisha, G1
Marasciulo-Rice, M1
Abio, H1
Rassi, C2
Rutazaana, D1
Rubahika, D1
Tibenderana, J1
Opigo, J1
Olukosi, AY1
Musa, AZ1
Ogbulafor, N1
Aina, O1
Mokuolu, O1
Oguche, S1
Wammanda, R1
Okafor, H1
Ekama, SO1
David, AN1
Happi, CT4
Ozor, L1
Babatunde, S1
Ijezie, SN1
Uhomoibhi, PE1
Awolola, ST1
Mohammed, AB1
Salako, BL1
Ibinaiye, T1
Oresanya, O1
Oguoma, C1
Aidenagbon, A1
Ogunmola, O1
Roh, ME1
Haro, A1
Somé, AF2
Yerbanga, RS2
Conrad, MD1
Wallender, E2
Legac, J1
Aweeka, F2
Rosenthal, PJ6
Colina-Vegas, L1
da Cruz B Silva, M1
de Souza Pereira, C1
Isis Barros, A1
Araújo Nobrega, J1
Navarro, M1
D'Alessandro, S1
Basilico, N1
Azevedo Batista, A1
Moreira, DRM1
Adjei, MR1
Kubio, C1
Buamah, M1
Sarfo, A1
Suuri, T1
Ibrahim, S1
Sadiq, A1
Abubakari, II1
Baafi, JV1
Makenga, G1
Francis, F1
Nakato, S1
Gesase, S2
Mtove, G1
Madebe, R1
Kyaruzi, E1
Minja, DTR1
Lusingu, JPA1
Geertruyden, JV1
Afolabi, MO1
Diaw, A1
Fall, EHB1
Sall, FB1
Diédhiou, A1
Seck, A1
Camara, B1
Niang, D1
Manga, IA1
Mbaye, I1
Sougou, NM1
Sow, D2
Greenwood, B13
Ndiaye, JLA1
Djimde, M1
Kayentao, K1
Tshiongo, JK1
Fofana, B2
Arama, C1
Beavogui, AH3
Mens, PF3
Schallig, HD1
Falade, CO4
Orimadegun, AE1
Michael, OS1
Dada-Adegbola, HO2
Ogunkunle, OO2
Badejo, JA2
Funwei, RI1
Ajayi, IO3
Jegede, AS1
Ojurongbe, OD1
Ssekitooleko, J1
Baba, E1
Hamade, P1
Webster, J1
Chandramohan, D10
Adepiti, AO3
Adeagbo, BA1
Adehin, A1
Bolaji, OO3
Elujoba, AA2
Ding, J1
Coldiron, ME2
Assao, B1
Guindo, O1
Blessborn, D1
Winterberg, M1
Grais, RF2
Koscalova, A1
Langendorf, C1
Rouamba, T1
Sondo, P1
Derra, K1
Nakanabo-Diallo, S1
Bihoun, B1
Rouamba, E1
Tarnagda, Z1
Kazienga, A1
Valea, I2
Sorgho, H1
Pagnoni, F4
Samadoulougou-Kirakoya, F1
Tinto, H4
Petersen, E1
Picot, S1
Mairet-Khedim, M1
Leang, R1
Marmai, C1
Khim, N1
Kim, S1
Ke, S1
Kauy, C1
Kloeung, N1
Eam, R1
Chy, S1
Izac, B1
Mey Bouth, D1
Dorina Bustos, M1
Ariey, F1
Witkowski, B1
Hema-Ouangraoua, S1
Kabore, NF1
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Carson, PE2
Hall, AP1
Segal, HE1
Pearlman, EJ1
Phintuyothin, P1
Kosakal, S1
Peters, W4
Robinson, BL1
Ye, XY2
Shao, BR2
Chu, YH2
Fadat, G1
Hengy, C3
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Trigg, PI1
Carme, B5
Moudzeo, H3
Mbitsi, A4
Samba, G2
Baird, JK1
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Kouka-Bemba, D2
Gazin, P2
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Kilimali, VA2
Sathounkazi, C1
Brandicourt, O2
Gentilini, M2
Dinis, DV1
Schapira, A2
Simooya, O1
Kofi-Ekue, JM1
Orme, ML2
Breckenridge, AM2
Arias, AE2
Corredor, A1
Macaigne, F1
Combe, A2
Vincendeau, P1
Eboumbou, J1
Garnier, T1
Michel, R1
Ripert, C2
Garrigue, G1
Abissègue, B1
Ghogomu, NA1
Gelas, H1
Lepelletier, L1
Nadire-Galliot, M1
Poman, JP1
Bellony, S1
Claustre, J1
Traore, BM1
Mouchet, J2
Ndumbe, PM1
Raymond, JM1
Dumas, F1
Baldit, C1
Couzigou, P1
Beraud, C1
Amouretti, M1
Pyakalyia, T1
Simooya, OO1
Aderounmu, AF1
Looareesuwan, S2
Karbwang, J2
Benjasurat, Y1
Attanath, P1
Warrell, DA3
Gascón, J1
Soldevila, M1
Merlos, A1
Bada, JL1
Hatton, CS1
Peto, TE1
Bunch, C2
Pasvol, G1
Russell, SJ1
Singer, CR1
Carr, R1
Larrey, D2
Castot, A1
Pëssayre, D2
Merigot, P1
Machayekhy, JP1
Feldmann, G1
Lenoir, A1
Rueff, B2
Benhamou, JP2
Zotter, GM2
Grainger, W1
Feldmeier, H2
Rougemont, A1
Dumbo, O1
Bouvier, M1
Soula, G1
Perrin, L1
Tamoura, B1
Yerly, S1
Dolo, A1
Brenner, E1
Kodio, B1
Rouveix, B1
Coulombel, L1
Aymard, JP1
Chau, F1
Abel, L1
Huang, OL1
Ouyang, WC1
Zhou, JX2
Wu, Z2
Zhang, KY2
Huang, JK2
Cai, XZ2
Pang, XJ1
Fu, SG2
Wang, XF1
Draper, CC1
Hills, M1
Brubaker, G1
Inambao, AW1
Graninger, W1
Rocha, RM1
Wiedermann, G1
Huang, QL1
Quyang, WC1
Pan, XJ1
Huang, XF1
McDermott, JM1
Heymann, DL2
Wirima, JJ2
Macheso, AP1
Wahl, RD1
Steketee, RW1
Rolfe, M1
Reyes, S1
Osanai, CH1
Passos, AD1
Neftel, KA1
Woodtly, W1
Schmid, M1
Frick, PG1
Fehr, J1
Sexton, JD1
Bugilimfura, L1
Sezibera, C1
Schwalbach, JF1
Biddulph, J1
Long, GW2
Watt, G2
Buck, RL2
Sangalang, RP1
Ranoa, CP2
Chiodini, PL1
Ndinga, M1
Eozenou, P1
Delmont, J1
Testa, J1
Monges, P1
Limbassa, J1
Georges, AJ1
Faugère, B1
Simon, F4
Porte, J2
Guigon, D1
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Calmel, MB1
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Scherrmann, JM1
Blayo, MC3
Khaliq, AA2
Fox, E2
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Liu, XM1
Lin, BY1
Zhang, JX1
Huang, LS1
Bernuau, J1
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Orme, M1
Macdonald, M1
Raccurt, CP1
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Beylot, J1
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Sangalang, R2
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Markus, MB1
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Siegrist, P1
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Dedet, JP1
Esterre, P1
Nicholl, DD2
Moir, JS2
Tulloch, JL2
Jolley, DJ2
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Smrkovski, LL1
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Rodriguez, CS1
Uylangco, CV1
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Cortes, GT1
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Bosseno, MF1
Lallemant, M1
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Mihaly, GW1
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Cantrell, W2
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Werbel, LM1

Clinical Trials (34)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Multi-centre, Open-label Randomised Trial to Assess the Efficacy, Safety and Tolerability of the Triple ACT Artemether-lumefantrine+Amodiaquine (AL+AQ) Compared to the ACT Artemether-lumefantrine (AL) in Uncomplicated Falciparum Malaria in Cambodia and [NCT03355664]Phase 3310 participants (Actual)Interventional2018-03-19Completed
Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE)[NCT03178643]Phase 4246 participants (Actual)Interventional2018-01-23Completed
Evaluation of the Effect of Artemisinin-based Combination Therapies on Urinary Schistosoma Haematobium When Administered for the Treatment of Malaria Co-infection[NCT04264130]Phase 254 participants (Actual)Interventional2018-07-31Completed
Effect of Single-course Malaria Chemoprevention on Clearance of and Protection From Plasmodium Falciparum Infection in the Presence of Resistance-associated Genotypes in Cameroon[NCT06173206]Phase 3900 participants (Anticipated)Interventional2024-03-15Not yet recruiting
Associations Between Drug Levels and the Risk of Malaria and Drug Resistance in the Setting of Seasonal Malaria Chemoprevention in Bobo-Dioulasso, Burkina Faso[NCT04969185]310 participants (Actual)Observational2021-08-16Completed
Effect of Single-course Malaria Chemoprevention on Clearance of and Protection From Plasmodium Falciparum Infection in the Presence of Resistance-associated Genotypes in Zambia[NCT06166498]Phase 3600 participants (Anticipated)Interventional2024-02-15Not yet recruiting
Feasibility, Acceptability and Costs of a Strategy Deploying Multiple First-lines Artemisinin-based Combination Therapies for Uncomplicated Malaria: a Pilot Programme in the Health District of Kaya, Burkina Faso[NCT04265573]150,000 participants (Actual)Observational2018-11-10Completed
An Open-label Individually Randomised Controlled Trial to Assess the Efficacy of Artemether-lumefantrine Prophylaxis for Malaria Among Forest Goers in Cambodia[NCT04041973]1,480 participants (Actual)Interventional2020-03-11Completed
Improving Neonatal Health Through Rapid Malaria Testing in Early Pregnancy With High-Sensitivity[NCT05757167]Phase 42,500 participants (Anticipated)Interventional2023-11-06Recruiting
Measuring the Impact of Seasonal Malaria Chemoprevention as Part of Routine Malaria Control in Kita, Mali[NCT02894294]1,162 participants (Actual)Observational [Patient Registry]2014-07-31Completed
Comparison of IST Using Ultra-sensitive Malaria Rapid Diagnostic Test and Pyronaridine - Artesunate - PYRAMAX®) to Standard IPT Sulfadoxine-pyrimethamine to Prevent Malaria in Pregnant Women Living in Endemic Areas[NCT04783051]Phase 3250 participants (Actual)Interventional2021-05-06Completed
Adherence to Artemisinin-Based Combination Therapy (ACT) for the Treatment of Malaria in Sierra Leone[NCT01967472]1,145 participants (Actual)Interventional2013-09-16Completed
A Trial of Seasonal Malaria Chemoprevention Plus Azithromycin in African Children[NCT02211729]Phase 322,090 participants (Actual)Interventional2014-05-31Completed
Incorporation of the 'Ottawa Malaria Decision Aid' Into the Pre-travel Consultation Process: Assessment of Travelers' Knowledge, Decisional Conflict, Preparation for Decision-making and Medication Adherence Compared to Standard Care[NCT01976325]100 participants (Anticipated)Interventional2014-01-31Recruiting
Infections in Migrants in Sweden - the Importance of Malaria and Other Parasitic Infections[NCT05086887]715 participants (Anticipated)Observational [Patient Registry]2019-04-15Recruiting
Clinical Efficacy of Artemisinin-based Combination Therapy for Treatment of Uncomplicated Plasmodium Falciparum Malaria in North Sumatera, Indonesia and the Association of Molecular Markers With Treatment Outcomes[NCT02325180]Phase 4338 participants (Actual)Interventional2015-01-31Completed
Safe and Efficacious Artemisinin-based Combination Treatments for African Pregnant Women With Malaria[NCT00852423]Phase 33,428 participants (Actual)Interventional2010-06-30Completed
Effectiveness of Seasonal Malaria Chemoprevention in Koulikoro, Mali[NCT04149106]Phase 34,556 participants (Anticipated)Interventional2019-07-01Active, not recruiting
Randomized Trial of the Efficacy, Safety, Tolerability and Pharmacokinetics of Dihydroartemisinin-piperaquine for Seasonal IPT to Prevent Malaria in Children Under 5 Years[NCT00941785]Phase 2/Phase 31,500 participants (Actual)Interventional2009-07-31Completed
Aetiology, Prevention and Control of Anaemia in Sub-Saharan Africa - Work Package 2: Efficacy Study: Efficacy of 2 Iron Fortified Porridges and IPT for the Prevention of Anemia in Young Children in Côte d'Ivoire.[NCT01634945]629 participants (Actual)Interventional2012-04-30Completed
Evaluation of the Public Health Impact and Cost Effectiveness of Seasonal Intermittent Preventive Treatment in Children in Senegal[NCT00712374]Phase 4100,000 participants (Anticipated)Interventional2008-09-30Enrolling by invitation
A Phase IIIB Comparative Trial of Seasonal Vaccination With the Malaria Vaccine RTS,S/AS01, Seasonal Malaria Chemoprevention and of the Two Interventions Combined[NCT03143218]Phase 35,920 participants (Actual)Interventional2017-04-17Completed
A Non-Inferiority, Open-Labelled, Randomised Trial Of The Efficacy And Safety Of Artesunate-Amodiaquine, Artemether-Lumefantrine, And Artesunate-Lapdap For Treatment Of Uncomplicated P. Falciparum Malaria Among Children In Ghana[NCT00119145]Phase 4510 participants (Anticipated)Interventional2005-06-30Completed
A Study Of Impact Of Intermittent Preventive Treatment In Children With Amodiaquine Plus Artesunate Versus Sulphadoxine-Pyrimethamine On Hemoglobin Levels And Malaria Morbidity In Hohoe District Of Ghana[NCT00119132]Phase 2/Phase 32,602 participants (Actual)Interventional2005-06-30Completed
Longitudinal Comparison of Combination Antimalarial Therapies in Ugandan Children: Evaluation of Safety, Tolerability, and Efficacy[NCT00123552]Phase 3601 participants (Actual)Interventional2004-11-30Completed
Treating Malaria During Pregnancy: A Randomized Trial of Potential Options for Treatment in an Area of High Drug Resistance in Tanzania[NCT00146731]Phase 3310 participants (Actual)Interventional2004-01-31Completed
Exploring the Impact of Scaling up Mass Testing, Treatment and Tracking on Malaria Prevalence Among Children in the Pakro Sub District of Ghana[NCT04167566]5,000 participants (Actual)Interventional2017-07-01Completed
A Trial of Intermittent Preventive Treatment and Home Based Management of Malaria in a Rural Area of The Gambia[NCT00944840]Phase 31,312 participants (Actual)Interventional2008-09-30Completed
Comparison of Two Strategies for the Delivery of Intermittent Preventive Treatment in Children (IPTc) in an Area of Seasonal Malaria Transmission[NCT00376155]Phase 414,000 participants (Actual)Interventional2006-05-31Completed
A Trial of the Combined Impact of Intermittent Preventive Treatment and Insecticide Treated Bednets in Reducing Morbidity From Malaria in African Children[NCT00738946]6,000 participants (Anticipated)Interventional2008-08-31Completed
Determining the Impact of Scaling up Mass Testing, Treatment and Tracking on Malaria Prevalence Among Children in the Pakro Sub District of Ghana[NCT04301531]5,861 participants (Actual)Interventional2020-03-01Completed
Intermittent Preventive Treatment (IPTi) for the Prevention of Malaria and Anaemia in PNG Infants[NCT00285662]1,100 participants (Anticipated)Interventional2006-06-30Completed
A Randomised Trial of the Efficacy and Safety of Four Drug Regimens When Used for Intermittent Preventive Treatment of Malaria in Senegalese Children[NCT00132548]Phase 32,200 participants Interventional2004-06-30Completed
Efficacy of Chloroquine (CQ) Alone Compared to Concomitant CQ and Primaquine (PQ) for the Treatment of Uncomplicated Plasmodium Vivax Infection[NCT02691910]Phase 2/Phase 3204 participants (Actual)Interventional2014-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Fever Clearance Time

The time taken for the tympanic temperature to fall below 37.5˚C and remain there for at least 24 hours (NCT03355664)
Timeframe: 42 day

InterventionHours to fever clearance (Mean)
Artemether-lumefantrine for 3 Days Plus Primaquine at Hour 2418.3
Artemether-lumefantrine for 3 Days Plus Amodiaquine for 3 Days Plus Primaquine at Hour 2414.9

Incidence of Adverse Events Concerning Markers of Hepatic or Renal Toxicity

Total bilirubin, Alanine transaminase, Aspartate transaminase, Alkaline phosphatase and creatinine will be measured (NCT03355664)
Timeframe: 42 day

InterventionEvents (Number)
Artemether-lumefantrine for 3 Days Plus Primaquine at Hour 2453
Artemether-lumefantrine for 3 Days Plus Amodiaquine for 3 Days Plus Primaquine at Hour 2463

Incidence of Prolongation of the Corrected QT Interval

We record the number of events where the QT interval exceeds 500ms or increases by 60ms or greater. (NCT03355664)
Timeframe: 28 day

InterventionEvents (Number)
Artemether-lumefantrine for 3 Days Plus Primaquine at Hour 240
Artemether-lumefantrine for 3 Days Plus Amodiaquine for 3 Days Plus Primaquine at Hour 240

Number of Severe Adverse Events by Study Arm

"All numerators in AE tables mean that the AE was reported as present according to the definitions defined in the US government DAIDS 2017 grading tables for reporting of adverse events. The AEs are reported without grading in this table, but are graded in the paper reporting this clinical trial.~All Primary analyses are reported (also in the accepted manuscript) along with the secondary outcomes needed to support the primary analysis. Secondary outcomes not involving the randomised comparison will be updated when the analyses are available. Please note that analyses of these Secondary outcomes will take time." (NCT03355664)
Timeframe: 42 days

InterventionParticipants (Number)
Artemether-lumefantrine for 3 Days Plus Primaquine at Hour 242
Artemether-lumefantrine for 3 Days Plus Amodiaquine for 3 Days Plus Primaquine at Hour 245

Parasite Clearance Half-life

Parasite clearance half-life assessed by microscopy as primary parameter to determine parasite clearance (NCT03355664)
Timeframe: 42 day

InterventionHours (Mean)
Artemether-lumefantrine for 3 Days Plus Primaquine at Hour 245
Artemether-lumefantrine for 3 Days Plus Amodiaquine for 3 Days Plus Primaquine at Hour 245.5

Polymerase Chain Reaction Corrected Efficacy Defined as Adequate Clinical and Parasitological Response (ACPR) by Study Arm

Efficacy is defined as participants, following initial parasite and fever clearance, not having a recrudescence of the original plasmodium infection and fever, up to 42 days of follow up. (NCT03355664)
Timeframe: 42 days

InterventionParticipants (Count of Participants)
Artemether-lumefantrine for 3 Days Plus Primaquine at Hour 24146
Artemether-lumefantrine for 3 Days Plus Amodiaquine for 3 Days Plus Primaquine at Hour 24151

Prolongation of the Corrected QT Interval

We record the number of events where the QT interval exceeds 500ms or increases by 60ms or greater. There were zero events of this at any time point in either study arm. So no further analyses are possible. (NCT03355664)
Timeframe: Hour 4, Hour 24, Hour 28, Hour 48, Hour 52, Hour 60, Hour 64, Day 7 and Day 28 and between these time points

InterventionEvents (Number)
Artemether-lumefantrine for 3 Days Plus Primaquine at Hour 240
Artemether-lumefantrine for 3 Days Plus Amodiaquine for 3 Days Plus Primaquine at Hour 240

42-day Polymerase Chain Reaction Corrected Efficacy According to Site/Geographic Region

42-day polymerase chain reaction corrected efficacy defined as adequate clinical and parasitological response (ACPR) according to site/geographic region. (NCT03355664)
Timeframe: 42 day

,
InterventionParticipants (Count of Participants)
West CambodiaEast CambodiaVietnam
Artemether-lumefantrine for 3 Days Plus Amodiaquine for 3 Days Plus Primaquine at Hour 24359026
Artemether-lumefantrine for 3 Days Plus Primaquine at Hour 24329123

Incidence of Clinical Episodes of Malaria

Passive surveillance to detect episode of fever (temperature > 37.5 C), or a history of fever within the past 48 hours, that is severe enough to require treatment at a health centre and which is accompanied by a positive blood film with a parasite density of 5,000 per µl or more (NCT03143218)
Timeframe: Passive surveillance of clinical episodes of malaria within the study area starting from the date of the first dose of study vaccines (April/May 2017) until 31st March 2020- a total of 36 months.

InterventionNo. of events/1000 person years at risk (Number)
SMC With SP+AQ304.8
RTS,S/AS01278.2
RTS,S/AS01 PLUS SMC With SP+AQ113.3

Reviews

35 reviews available for amodiaquine and Malaria

ArticleYear
Current progress in antimalarial pharmacotherapy and multi-target drug discovery.
    European journal of medicinal chemistry, 2020, Feb-15, Volume: 188

    Topics: Animals; Antimalarials; Artemisinins; Drug Discovery; Drug Resistance; Humans; Malaria; Molecular St

2020
Therapeutic efficacy of artemether-lumefantrine, artesunate-amodiaquine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Sub-Saharan Africa: A systematic review and meta-analysis.
    PloS one, 2022, Volume: 17, Issue:3

    Topics: Africa South of the Sahara; Amodiaquine; Antimalarials; Artemether; Artemether, Lumefantrine Drug Co

2022
Pharmacokinetic considerations in seasonal malaria chemoprevention.
    Trends in parasitology, 2022, Volume: 38, Issue:8

    Topics: Amodiaquine; Antimalarials; Chemoprevention; Child; Child, Preschool; Drug Combinations; Drug Therap

2022
Malaria PK/PD and the Role Pharmacometrics Can Play in the Global Health Arena: Malaria Treatment Regimens for Vulnerable Populations.
    Clinical pharmacology and therapeutics, 2021, Volume: 110, Issue:4

    Topics: Amodiaquine; Anti-HIV Agents; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins

2021
Intermittent preventive treatment for malaria in infants.
    The Cochrane database of systematic reviews, 2021, 07-17, Volume: 7

    Topics: Africa South of the Sahara; Amodiaquine; Antimalarials; Artemisinins; Bias; Confidence Intervals; Di

2021
Animal Embryotoxicity Studies of Key Non-Artemisinin Antimalarials and Use in Women in the First Trimester.
    Birth defects research, 2017, Aug-15, Volume: 109, Issue:14

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Drug Combinations; Female; Humans; Malaria; Malar

2017
Malaria.
    Lancet (London, England), 2014, Feb-22, Volume: 383, Issue:9918

    Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate

2014
Malaria.
    Lancet (London, England), 2014, Feb-22, Volume: 383, Issue:9918

    Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate

2014
Malaria.
    Lancet (London, England), 2014, Feb-22, Volume: 383, Issue:9918

    Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate

2014
Malaria.
    Lancet (London, England), 2014, Feb-22, Volume: 383, Issue:9918

    Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate

2014
Malaria.
    Lancet (London, England), 2014, Feb-22, Volume: 383, Issue:9918

    Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate

2014
Malaria.
    Lancet (London, England), 2014, Feb-22, Volume: 383, Issue:9918

    Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate

2014
Malaria.
    Lancet (London, England), 2014, Feb-22, Volume: 383, Issue:9918

    Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate

2014
Malaria.
    Lancet (London, England), 2014, Feb-22, Volume: 383, Issue:9918

    Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate

2014
Malaria.
    Lancet (London, England), 2014, Feb-22, Volume: 383, Issue:9918

    Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate

2014
Cytochrome P450 enzymes and genotype-guided drug therapy.
    Current opinion in molecular therapeutics, 2009, Volume: 11, Issue:6

    Topics: Amodiaquine; Anticoagulants; Antimalarials; Breast Neoplasms; Cytochrome P-450 Enzyme System; Estrog

2009
Biowaiver monographs for immediate release solid oral dosage forms: amodiaquine hydrochloride.
    Journal of pharmaceutical sciences, 2012, Volume: 101, Issue:12

    Topics: Administration, Oral; Amodiaquine; Animals; Antimalarials; Excipients; Humans; Malaria; Tablets; The

2012
Glutathione is involved in the antimalarial action of chloroquine and its modulation affects drug sensitivity of human and murine species of Plasmodium.
    Redox report : communications in free radical research, 2003, Volume: 8, Issue:5

    Topics: Acetylcysteine; Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Glutathione; Hemi

2003
Can amodiaquine be used safely during pregnancy?
    The Lancet. Infectious diseases, 2004, Volume: 4, Issue:4

    Topics: Africa; Amodiaquine; Antimalarials; Contraindications; Female; Humans; Malaria; Pregnancy; Pregnancy

2004
Malaria intermittent preventive treatment in infants, chemoprophylaxis, and childhood vaccinations.
    Lancet (London, England), 2004, Apr-24, Volume: 363, Issue:9418

    Topics: Amodiaquine; Antibody Formation; Antimalarials; Humans; Immunity, Cellular; Infant; Malaria; Vaccine

2004
[Combined antimalarial therapy using artemisinin].
    Parassitologia, 2004, Volume: 46, Issue:1-2

    Topics: Amodiaquine; Animals; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Doxycycline;

2004
Antimalarial drugs: QT prolongation and cardiac arrhythmias.
    Expert opinion on drug safety, 2005, Volume: 4, Issue:3

    Topics: Amodiaquine; Drug Approval; Electrophysiology; Humans; Long QT Syndrome; Malaria; Phenanthrenes; Ris

2005
Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria.
    The Cochrane database of systematic reviews, 2005, Oct-19, Issue:4

    Topics: Adult; Amodiaquine; Chloroquine; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; Mala

2005
[Cytochrome P-450 and the response to antimalarial drugs].
    Revista panamericana de salud publica = Pan American journal of public health, 2006, Volume: 19, Issue:1

    Topics: Administration, Oral; Adult; Amodiaquine; Animals; Antimalarials; Biotransformation; Child; Chloroqu

2006
Resisting resistance: dealing with the irrepressible problem of malaria.
    British journal of clinical pharmacology, 2006, Volume: 61, Issue:6

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Dapsone; Drug Combinations; Drug Resistance; H

2006
Malaria prophylaxis in travellers: the current position.
    Experientia, 1984, Dec-15, Volume: 40, Issue:12

    Topics: Africa; Amodiaquine; Antimalarials; Asia; Chloroquine; Culicidae; Drug Resistance; Female; Humans; I

1984
Falciparum malaria: the urgent need for safe and effective drugs.
    Annual review of medicine, 1983, Volume: 34

    Topics: Amodiaquine; Anti-Bacterial Agents; Antimalarials; Dapsone; Drug Combinations; Humans; Malaria; Plas

1983
[Drug resistance in malaria].
    Annales de la Societe belge de medecine tropicale, 1980, Volume: 60, Issue:2

    Topics: Africa; Amodiaquine; Animals; Asia; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmo

1980
The present status of malaria chemotherapy: mefloquine, a novel antimalarial.
    Medicinal research reviews, 1981,Fall, Volume: 1, Issue:3

    Topics: Amodiaquine; Animals; Antimalarials; Aotus trivirgatus; Chemical Phenomena; Chemistry; Chloroquine;

1981
Comparative efficacy and safety of chloroquine and alternative antimalarial drugs: a meta-analysis from six African countries.
    East African medical journal, 1999, Volume: 76, Issue:6

    Topics: Africa, Eastern; Africa, Western; Amodiaquine; Antimalarials; Chloroquine; Drug Combinations; Drug C

1999
Amodiaquine for treating malaria.
    The Cochrane database of systematic reviews, 2000, Issue:2

    Topics: Amodiaquine; Antimalarials; Humans; Malaria

2000
Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria.
    The Cochrane database of systematic reviews, 2000, Issue:2

    Topics: Adult; Amodiaquine; Chloroquine; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; Mala

2000
Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria.
    The Cochrane database of systematic reviews, 2001, Issue:4

    Topics: Adult; Amodiaquine; Chloroquine; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; Mala

2001
[Current information on treatment and prophylaxis of malaria (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1979, Dec-14, Volume: 121, Issue:50

    Topics: Adolescent; Adult; Amodiaquine; Child; Child, Preschool; Chloroquine; Dose-Response Relationship, Dr

1979
Malaria chemoprophylaxis: an update.
    Papua and New Guinea medical journal, 1987, Volume: 30, Issue:1

    Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Child, Preschool; Dapsone; Drug Combinations; Female;

1987
The chemoprophylaxis of malaria.
    The Journal of antimicrobial chemotherapy, 1987, Volume: 20, Issue:3

    Topics: Amodiaquine; Animals; Chloroquine; Dapsone; Drug Combinations; Drug Resistance; Malaria; Plasmodium

1987
Recent advances in antimalarial chemotherapy and drug resistance.
    Advances in parasitology, 1974, Volume: 12

    Topics: Agglutination; Amodiaquine; Animals; Anti-Bacterial Agents; Antimalarials; Chloroquine; Cross Reacti

1974
The problem of drug-resistant malaria.
    The American journal of tropical medicine and hygiene, 1972, Volume: 21, Issue:5

    Topics: Amodiaquine; Anopheles; Antimalarials; Asia; Chloroquine; Drug Resistance, Microbial; Humans; Insect

1972
Development of new antimalarial drugs.
    The American journal of tropical medicine and hygiene, 1972, Volume: 21, Issue:5

    Topics: Amodiaquine; Antimalarials; Chloroquine; Drug Resistance, Microbial; Folic Acid Antagonists; Humans;

1972
[Importation of malaria into the Federal Republic of Germany including Berlin (West) in the last ten years (1963-1972)].
    Deutsche medizinische Wochenschrift (1946), 1974, Volume: 99, Issue:18

    Topics: Africa; Age Factors; Aircraft; Amodiaquine; Antimalarials; Asia; Berlin; Chloroquine; Disease Outbre

1974
New perspectives on the chemotherapy of malaria, filariasis, and leprosy.
    Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 1974, Volume: 18

    Topics: Amodiaquine; Aniline Compounds; Antimalarials; Chloroquine; Cresols; Dapsone; Drug Resistance; Filar

1974
The pharmacology of the antimalarials. A rational approach to the therapy of resistant falciparum malaria.
    Archives of internal medicine, 1969, Volume: 123, Issue:6

    Topics: Amodiaquine; Antimalarials; Chemical Phenomena; Chemistry; Chloroquine; Dapsone; Drug Resistance, Mi

1969
Malaria. Chemoprophylaxis and chemotherapy.
    British medical journal, 1971, Apr-10, Volume: 2, Issue:5753

    Topics: Amodiaquine; Antimalarials; Chloroquine; Dapsone; Drug Resistance, Microbial; Drug Synergism; Humans

1971

Trials

74 trials available for amodiaquine and Malaria

ArticleYear
Triple therapy with artemether-lumefantrine plus amodiaquine versus artemether-lumefantrine alone for artemisinin-resistant, uncomplicated falciparum malaria: an open-label, randomised, multicentre trial.
    The Lancet. Infectious diseases, 2022, Volume: 22, Issue:6

    Topics: Amodiaquine; Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artemisinins; Dru

2022
Overall and Gender-Specific Effects of Intermittent Preventive Treatment of Malaria with Artemisinin-Based Combination Therapies among Schoolchildren in Mali: A Three-Group Open Label Randomized Controlled Trial.
    The American journal of tropical medicine and hygiene, 2022, 10-12, Volume: 107, Issue:4

    Topics: Amodiaquine; Anemia; Antimalarials; Artemisinins; Artesunate; Child; Drug Combinations; Drug Therapy

2022
Monthly sulfadoxine/pyrimethamine-amodiaquine or dihydroartemisinin-piperaquine as malaria chemoprevention in young Kenyan children with sickle cell anemia: A randomized controlled trial.
    PLoS medicine, 2022, Volume: 19, Issue:10

    Topics: Amodiaquine; Anemia, Sickle Cell; Antimalarials; Artemisinins; Chemoprevention; Child; Child, Presch

2022
Effectiveness of antimalarial drug combinations in treating concomitant urogenital schistosomiasis in malaria patients in Lambaréné, Gabon: A non-randomised event-monitoring study.
    PLoS neglected tropical diseases, 2022, Volume: 16, Issue:10

    Topics: Amodiaquine; Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artesunate; Drug

2022
A non-randomized controlled trial to assess the protective effect of SMC in the context of high parasite resistance in Uganda.
    Malaria journal, 2023, Feb-22, Volume: 22, Issue:1

    Topics: Amodiaquine; Animals; Antimalarials; Chemoprevention; Child; Drug Combinations; Humans; Infant; Mala

2023
Effectiveness and safety of intermittent preventive treatment with dihydroartemisinin-piperaquine or artesunate-amodiaquine for reducing malaria and related morbidities in schoolchildren in Tanzania: a randomised controlled trial.
    The Lancet. Global health, 2023, Volume: 11, Issue:8

    Topics: Amodiaquine; Antimalarials; Artesunate; Child; COVID-19; Drug Combinations; Hemoglobins; Humans; Inc

2023
Provider and User Acceptability of Integrated Treatment for the Control of Malaria and Helminths in Saraya, South-Eastern Senegal.
    The American journal of tropical medicine and hygiene, 2023, 11-01, Volume: 109, Issue:5

    Topics: Adolescent; Adult; Aged; Amodiaquine; Animals; Child; Female; Helminthiasis; Helminths; Humans; Mala

2023
Efficacy of artemether-lumefantrine and artesunate-amodiaquine as first line therapy of uncomplicated malaria in Burkina Faso, 11 years after policy change.
    The Pan African medical journal, 2020, Volume: 35

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Bur

2020
Efficacy and safety of artesuante-amodiaquine and artemether lumefantrine, the first line malaria treatment in six sentinel's sites of Côte d'Ivoire, West Africa.
    Annals of parasitology, 2020, Volume: 66, Issue:4

    Topics: Amodiaquine; Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artemisinins; Cot

2020
Unanticipated CNS Safety Signal in a Placebo-Controlled, Randomized Trial of Co-Administered Atovaquone-Proguanil and Amodiaquine.
    Clinical pharmacology and therapeutics, 2022, Volume: 111, Issue:4

    Topics: Amodiaquine; Antimalarials; Atovaquone; Drug Combinations; Drug Therapy, Combination; Female; Humans

2022
Efficacy of Artesunate/Amodiaquine in the Treatment of Uncomplicated Malaria among Children in Ghana.
    The American journal of tropical medicine and hygiene, 2017, Volume: 97, Issue:3

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemisinins; Child; Child, Preschool; Drug Combinations; Gh

2017
Pyronaridine-artesunate or dihydroartemisinin-piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial.
    Lancet (London, England), 2018, 04-07, Volume: 391, Issue:10128

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Art

2018
Pyronaridine-artesunate or dihydroartemisinin-piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial.
    Lancet (London, England), 2018, 04-07, Volume: 391, Issue:10128

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Art

2018
Pyronaridine-artesunate or dihydroartemisinin-piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial.
    Lancet (London, England), 2018, 04-07, Volume: 391, Issue:10128

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Art

2018
Pyronaridine-artesunate or dihydroartemisinin-piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial.
    Lancet (London, England), 2018, 04-07, Volume: 391, Issue:10128

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Art

2018
Adherence to treatment with artemether-lumefantrine or amodiaquine-artesunate for uncomplicated malaria in children in Sierra Leone: a randomized trial.
    Malaria journal, 2018, Jun-04, Volume: 17, Issue:1

    Topics: Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Child; Child, P

2018
Population Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis To Optimize Dosing.
    Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:10

    Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Child; Child, Preschool; Drug Administration Schedule

2018
Impact of treating young children with antimalarials with or without antibiotics on morbidity: a cluster-randomized controlled trial in Ghana.
    International health, 2013, Volume: 5, Issue:3

    Topics: Amodiaquine; Amoxicillin; Anemia; Anti-Bacterial Agents; Antimalarials; Artemisinins; Caregivers; Ch

2013
Evaluation of the comparative efficacy and safety of artemether-lumefantrine, artesunate-amodiaquine and artesunate-amodiaquine-chlorpheniramine (Artemoclo™) for the treatment of acute uncomplicated malaria in Nigerian children.
    Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2014, Volume: 23, Issue:3

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemether; Artemisinins; Child; Child, Preschool; Chlorphen

2014
Safe and efficacious artemisinin-based combination treatments for African pregnant women with malaria: a multicentre randomized control trial.
    Reproductive health, 2015, Jan-15, Volume: 12

    Topics: Adult; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesuna

2015
Validation and pharmacokinetic application of a high-performance liquid chromatographic technique for determining the concentrations of amodiaquine and its metabolite in plasma of patients treated with oral fixed-dose amodiaquine-artesunate combination in
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:9

    Topics: Administration, Oral; Adult; Amodiaquine; Antimalarials; Artemisinins; Artesunate; Chromatography, H

2015
Randomized Noninferiority Trial of Dihydroartemisinin-Piperaquine Compared with Sulfadoxine-Pyrimethamine plus Amodiaquine for Seasonal Malaria Chemoprevention in Burkina Faso.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:8

    Topics: Amodiaquine; Antimalarials; Artemisinins; Burkina Faso; Case-Control Studies; Chemoprevention; Child

2015
Randomized Noninferiority Trial of Dihydroartemisinin-Piperaquine Compared with Sulfadoxine-Pyrimethamine plus Amodiaquine for Seasonal Malaria Chemoprevention in Burkina Faso.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:8

    Topics: Amodiaquine; Antimalarials; Artemisinins; Burkina Faso; Case-Control Studies; Chemoprevention; Child

2015
Randomized Noninferiority Trial of Dihydroartemisinin-Piperaquine Compared with Sulfadoxine-Pyrimethamine plus Amodiaquine for Seasonal Malaria Chemoprevention in Burkina Faso.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:8

    Topics: Amodiaquine; Antimalarials; Artemisinins; Burkina Faso; Case-Control Studies; Chemoprevention; Child

2015
Randomized Noninferiority Trial of Dihydroartemisinin-Piperaquine Compared with Sulfadoxine-Pyrimethamine plus Amodiaquine for Seasonal Malaria Chemoprevention in Burkina Faso.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:8

    Topics: Amodiaquine; Antimalarials; Artemisinins; Burkina Faso; Case-Control Studies; Chemoprevention; Child

2015
The effect of iron-fortified complementary food and intermittent preventive treatment of malaria on anaemia in 12- to 36-month-old children: a cluster-randomised controlled trial.
    Malaria journal, 2015, Sep-17, Volume: 14

    Topics: Amodiaquine; Anemia; Antimalarials; Child, Preschool; Cote d'Ivoire; Diphosphates; Drug Combinations

2015
Seasonal malaria chemoprevention in an area of extended seasonal transmission in Ashanti, Ghana: an individually randomised clinical trial.
    Tropical medicine & international health : TM & IH, 2016, Volume: 21, Issue:2

    Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Chemoprevention; Child, Preschool; Drug Combin

2016
Safety of Seasonal Malaria Chemoprevention (SMC) with Sulfadoxine-Pyrimethamine plus Amodiaquine when Delivered to Children under 10 Years of Age by District Health Services in Senegal: Results from a Stepped-Wedge Cluster Randomized Trial.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Amodiaquine; Antimalarials; Chemoprevention; Child; Child, Preschool; Drug Combinations; Drug Therap

2016
Safety of Seasonal Malaria Chemoprevention (SMC) with Sulfadoxine-Pyrimethamine plus Amodiaquine when Delivered to Children under 10 Years of Age by District Health Services in Senegal: Results from a Stepped-Wedge Cluster Randomized Trial.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Amodiaquine; Antimalarials; Chemoprevention; Child; Child, Preschool; Drug Combinations; Drug Therap

2016
Safety of Seasonal Malaria Chemoprevention (SMC) with Sulfadoxine-Pyrimethamine plus Amodiaquine when Delivered to Children under 10 Years of Age by District Health Services in Senegal: Results from a Stepped-Wedge Cluster Randomized Trial.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Amodiaquine; Antimalarials; Chemoprevention; Child; Child, Preschool; Drug Combinations; Drug Therap

2016
Safety of Seasonal Malaria Chemoprevention (SMC) with Sulfadoxine-Pyrimethamine plus Amodiaquine when Delivered to Children under 10 Years of Age by District Health Services in Senegal: Results from a Stepped-Wedge Cluster Randomized Trial.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Amodiaquine; Antimalarials; Chemoprevention; Child; Child, Preschool; Drug Combinations; Drug Therap

2016
Effectiveness of Seasonal Malaria Chemoprevention in Children under Ten Years of Age in Senegal: A Stepped-Wedge Cluster-Randomised Trial.
    PLoS medicine, 2016, Volume: 13, Issue:11

    Topics: Amodiaquine; Antimalarials; Chemoprevention; Child; Child, Preschool; Drug Combinations; Humans; Inf

2016
An open label, randomised trial of artesunate+amodiaquine, artesunate+chlorproguanil-dapsone and artemether-lumefantrine for the treatment of uncomplicated malaria.
    PloS one, 2008, Jun-25, Volume: 3, Issue:6

    Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone;

2008
[Efficacy of the amodiaquine+sulfadoxine-pyrimethamine combination and of chloroquine for the treatment of malaria in Córdoba, Colombia, 2006].
    Biomedica : revista del Instituto Nacional de Salud, 2008, Volume: 28, Issue:1

    Topics: Adolescent; Adult; Amodiaquine; Animals; Antimalarials; Child; Chloroquine; Colombia; Drug Combinati

2008
Seasonal intermittent preventive treatment for the prevention of anaemia and malaria in Ghanaian children: a randomized, placebo controlled trial.
    PloS one, 2008, Volume: 3, Issue:12

    Topics: Amodiaquine; Anemia; Antimalarials; Artemisinins; Artesunate; Child, Preschool; Drug Combinations; G

2008
Decreasing efficacy of antimalarial combination therapy in Uganda is explained by decreasing host immunity rather than increasing drug resistance.
    The Journal of infectious diseases, 2009, Mar-01, Volume: 199, Issue:5

    Topics: Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Drug Combinations; Drug Resistance; Dr

2009
Randomized trial of artesunate+amodiaquine, sulfadoxine-pyrimethamine+amodiaquine, chlorproguanal-dapsone and SP for malaria in pregnancy in Tanzania.
    PloS one, 2009, Volume: 4, Issue:4

    Topics: Adult; Amodiaquine; Artemisinins; Artesunate; Dapsone; Drug Combinations; Drug Therapy, Combination;

2009
Impact of ministry of health interventions on private medicine retailer knowledge and practices on anti-malarial treatment in Kenya.
    The American journal of tropical medicine and hygiene, 2009, Volume: 80, Issue:6

    Topics: Amodiaquine; Antimalarials; Commerce; Community Health Services; Health Knowledge, Attitudes, Practi

2009
Population pharmacokinetics of artesunate and amodiaquine in African children.
    Malaria journal, 2009, Aug-20, Volume: 8

    Topics: Africa; Amodiaquine; Antimalarials; Artemisinins; Artesunate; Biological Availability; Biotransforma

2009
Argemone mexicana decoction versus artesunate-amodiaquine for the management of malaria in Mali: policy and public-health implications.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 2010, Volume: 104, Issue:1

    Topics: Adolescent; Amodiaquine; Antimalarials; Argemone; Artemisinins; Child; Child, Preschool; Drug Combin

2010
Effectiveness of combined intermittent preventive treatment for children and timely home treatment for malaria control.
    Malaria journal, 2009, Dec-11, Volume: 8

    Topics: Adult; Amodiaquine; Animals; Antimalarials; Artemisinins; Artesunate; Caregivers; Child, Preschool;

2009
Amodiaquine dosage and tolerability for intermittent preventive treatment to prevent malaria in children.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:3

    Topics: Age Factors; Amodiaquine; Antimalarials; Body Weight; Child; Child, Preschool; Dose-Response Relatio

2010
Use of area under the curve to evaluate the effects of antimalarial drugs on malaria-associated anemia after treatment.
    American journal of therapeutics, 2011, Volume: 18, Issue:3

    Topics: Amodiaquine; Anemia; Antimalarials; Area Under Curve; Artemether, Lumefantrine Drug Combination; Art

2011
Incidence of malaria and efficacy of combination antimalarial therapies over 4 years in an urban cohort of Ugandan children.
    PloS one, 2010, Jul-30, Volume: 5, Issue:7

    Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Child; Child, Preschool; Drug Comb

2010
Cost effectiveness of seasonal intermittent preventive treatment using amodiaquine & artesunate or sulphadoxine-pyrimethamine in Ghanaian children.
    PloS one, 2010, Aug-17, Volume: 5, Issue:8

    Topics: Amodiaquine; Anemia; Antimalarials; Artemisinins; Artesunate; Child, Preschool; Cost-Benefit Analysi

2010
Is parasite clearance clinically important after malaria treatment in a high transmission area? A 3-month follow-up of home-based management with herbal medicine or ACT.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 2011, Volume: 105, Issue:1

    Topics: Adolescent; Amodiaquine; Antimalarials; Argemone; Artemisinins; Child; Child, Preschool; Drug Combin

2011
A trial of intermittent preventive treatment and home-based management of malaria in a rural area of The Gambia.
    Malaria journal, 2011, Jan-07, Volume: 10

    Topics: Amodiaquine; Antimalarials; Child, Preschool; Double-Blind Method; Drug Combinations; Female; Gambia

2011
Two strategies for the delivery of IPTc in an area of seasonal malaria transmission in the Gambia: a randomised controlled trial.
    PLoS medicine, 2011, Feb-01, Volume: 8, Issue:2

    Topics: Amodiaquine; Antimalarials; Child; Child, Preschool; Drug Combinations; Female; Humans; Infant; Inse

2011
Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Burkina Faso: a randomised, double-blind, placebo-controlled trial.
    PLoS medicine, 2011, Feb-01, Volume: 8, Issue:2

    Topics: Amodiaquine; Antimalarials; Burkina Faso; Child, Preschool; Double-Blind Method; Drug Combinations;

2011
Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Burkina Faso: a randomised, double-blind, placebo-controlled trial.
    PLoS medicine, 2011, Feb-01, Volume: 8, Issue:2

    Topics: Amodiaquine; Antimalarials; Burkina Faso; Child, Preschool; Double-Blind Method; Drug Combinations;

2011
Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Burkina Faso: a randomised, double-blind, placebo-controlled trial.
    PLoS medicine, 2011, Feb-01, Volume: 8, Issue:2

    Topics: Amodiaquine; Antimalarials; Burkina Faso; Child, Preschool; Double-Blind Method; Drug Combinations;

2011
Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Burkina Faso: a randomised, double-blind, placebo-controlled trial.
    PLoS medicine, 2011, Feb-01, Volume: 8, Issue:2

    Topics: Amodiaquine; Antimalarials; Burkina Faso; Child, Preschool; Double-Blind Method; Drug Combinations;

2011
Effects of amodiaquine and artesunate on sulphadoxine-pyrimethamine pharmacokinetic parameters in children under five in Mali.
    Malaria journal, 2011, Sep-21, Volume: 10

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Blood Chemical Analysis; Child, Preschool; Dru

2011
Intermittent preventive treatment for malaria in Papua New Guinean infants exposed to Plasmodium falciparum and P. vivax: a randomized controlled trial.
    PLoS medicine, 2012, Volume: 9, Issue:3

    Topics: Amodiaquine; Antimalarials; Drug Combinations; Female; Humans; Infant; Infant, Newborn; Malaria; Mal

2012
The efficacy and tolerability of artemisinin-piperaquine (Artequick®) versus artesunate-amodiaquine (Coarsucam™) for the treatment of uncomplicated Plasmodium falciparum malaria in south-central Vietnam.
    Malaria journal, 2012, Jun-28, Volume: 11

    Topics: Adolescent; Adult; Amodiaquine; Animals; Artemisinins; Blood; Child; Child, Preschool; Drug Combinat

2012
Repeated artemisinin-based combination therapies in a malaria hyperendemic area of Mali: efficacy, safety, and public health impact.
    The American journal of tropical medicine and hygiene, 2012, Volume: 87, Issue:1

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Chi

2012
Impact of community management of fever (using antimalarials with or without antibiotics) on childhood mortality: a cluster-randomized controlled trial in Ghana.
    The American journal of tropical medicine and hygiene, 2012, Volume: 87, Issue:5 Suppl

    Topics: Amodiaquine; Amoxicillin; Anti-Bacterial Agents; Antibiotics, Antitubercular; Antimalarials; Artemis

2012
Electrocardiographic study in Ghanaian children with uncomplicated malaria, treated with artesunate-amodiaquine or artemether-lumefantrine.
    Malaria journal, 2012, Dec-17, Volume: 11

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Bra

2012
[Efficacy of amodiaquine and sulfadoxine/pyrimethamine in the treatment of malaria not complicated by Plasmodium falciparum in Nariño, Colombia, 1999-2002].
    Biomedica : revista del Instituto Nacional de Salud, 2003, Volume: 23, Issue:1

    Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Child; Child, Preschool; Colombia; Drug Combinations;

2003
Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda.
    PLoS medicine, 2005, Volume: 2, Issue:7

    Topics: Amodiaquine; Antimalarials; Artemisinins; Child, Preschool; Chloroquine; Drug Combinations; Drug The

2005
Malaria chemoprophylaxis and the serologic response to measles and diphtheria-tetanus-whole-cell pertussis vaccines.
    Malaria journal, 2005, Nov-06, Volume: 4

    Topics: Amodiaquine; Antimalarials; Child; Child, Preschool; Diphtheria-Tetanus-Pertussis Vaccine; Female; H

2005
Antischistosomal efficacy of artesunate combination therapies administered as curative treatments for malaria attacks.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 2007, Volume: 101, Issue:2

    Topics: Amodiaquine; Animals; Anthelmintics; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschoo

2007
Artesunate + amodiaquine and artesunate + sulphadoxine-pyrimethamine for treatment of uncomplicated malaria in Democratic Republic of Congo: a clinical trial with determination of sulphadoxine and pyrimethamine-resistant haplotypes.
    Tropical medicine & international health : TM & IH, 2006, Volume: 11, Issue:10

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Artesunate; Child, Preschool; Democratic Republic

2006
Feasibility and acceptability of artemisinin-based combination therapy for the home management of malaria in four African sites.
    Malaria journal, 2008, Jan-08, Volume: 7

    Topics: Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Child, Preschoo

2008
A trial of the efficacy, safety and impact on drug resistance of four drug regimens for seasonal intermittent preventive treatment for malaria in Senegalese children.
    PloS one, 2008, Jan-23, Volume: 3, Issue:1

    Topics: Amodiaquine; Antimalarials; Arsenites; Child; Drug Combinations; Drug Resistance; Drug Therapy, Comb

2008
A trial of the efficacy, safety and impact on drug resistance of four drug regimens for seasonal intermittent preventive treatment for malaria in Senegalese children.
    PloS one, 2008, Jan-23, Volume: 3, Issue:1

    Topics: Amodiaquine; Antimalarials; Arsenites; Child; Drug Combinations; Drug Resistance; Drug Therapy, Comb

2008
A trial of the efficacy, safety and impact on drug resistance of four drug regimens for seasonal intermittent preventive treatment for malaria in Senegalese children.
    PloS one, 2008, Jan-23, Volume: 3, Issue:1

    Topics: Amodiaquine; Antimalarials; Arsenites; Child; Drug Combinations; Drug Resistance; Drug Therapy, Comb

2008
A trial of the efficacy, safety and impact on drug resistance of four drug regimens for seasonal intermittent preventive treatment for malaria in Senegalese children.
    PloS one, 2008, Jan-23, Volume: 3, Issue:1

    Topics: Amodiaquine; Antimalarials; Arsenites; Child; Drug Combinations; Drug Resistance; Drug Therapy, Comb

2008
High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2008, Apr-01, Volume: 46, Issue:7

    Topics: Amodiaquine; Anti-HIV Agents; Antimalarials; Artemisinins; Artesunate; Chemoprevention; Child; Child

2008
Effectiveness of amodiaquine as treatment for chloroquine-resistant Plasmodium falciparum infections in Kenya.
    Lancet (London, England), 1984, Feb-18, Volume: 1, Issue:8373

    Topics: Adolescent; Amodiaquine; Blood; Child; Chloroquine; Drug Combinations; Drug Resistance, Microbial; F

1984
Amodiaquine more effective than chloroquine against Plasmodium falciparum malaria on Kenya coast.
    Lancet (London, England), 1984, Apr-28, Volume: 1, Issue:8383

    Topics: Amodiaquine; Child; Chloroquine; Humans; Kenya; Malaria; Plasmodium falciparum

1984
The present status of malaria chemotherapy: mefloquine, a novel antimalarial.
    Medicinal research reviews, 1981,Fall, Volume: 1, Issue:3

    Topics: Amodiaquine; Animals; Antimalarials; Aotus trivirgatus; Chemical Phenomena; Chemistry; Chloroquine;

1981
Amodiaquine resistant falciparum malaria in Thailand.
    The American journal of tropical medicine and hygiene, 1975, Volume: 24, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Aminoquinolines; Amodiaquine; Chloroquine; Chromatography;

1975
[Comparative study of sulfadoxine-pyrimethamine and amodiaquine + sulfadoxine-pyrimethamine for the treatment of malaria caused by chloroquine-resistant Plasmodium falciparum in Maputo, Mozambique].
    Bulletin de la Societe de pathologie exotique (1990), 1990, Volume: 83, Issue:4

    Topics: Adult; Amodiaquine; Animals; Chloroquine; Drug Combinations; Drug Resistance; Drug Therapy, Combinat

1990
Sensitivity of Plasmodium falciparum to chloroquine, amodiaquine and mefloquine in Ibadan, Nigeria.
    African journal of medicine and medical sciences, 1988, Volume: 17, Issue:1

    Topics: Amodiaquine; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; In Vitr

1988
Effectiveness of amodiaquine, sulfadoxine-pyrimethamine, and combinations of these drugs for treating chloroquine-resistant falciparum malaria in Hainan Island, China.
    Bulletin of the World Health Organization, 1988, Volume: 66, Issue:3

    Topics: Adolescent; Adult; Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Therapy,

1988
A comparative trial of three regimens for treating uncomplicated falciparum malaria in Acre, Brazil.
    The Journal of infectious diseases, 1988, Volume: 158, Issue:6

    Topics: Adolescent; Adult; Amodiaquine; Animals; Antimalarials; Brazil; Clindamycin; Clinical Trials as Topi

1988
Falciparum malaria and pregnancy: relationship and treatment response.
    The Southeast Asian journal of tropical medicine and public health, 1988, Volume: 19, Issue:2

    Topics: Adolescent; Adult; Amodiaquine; Animals; Female; Humans; Malaria; Plasmodium falciparum; Pregnancy;

1988
[Efficacy of amodiaquine, Fansidar and their combination in the treatment of chloroquine-resistant falciparum malaria].
    Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1988, Volume: 6, Issue:4

    Topics: Adolescent; Adult; Amodiaquine; Animals; Antimalarials; Chloroquine; Double-Blind Method; Drug Combi

1988
Efficacy of chemoprophylaxis in preventing Plasmodium falciparum parasitaemia and placental infection in pregnant women in Malawi.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1988, Volume: 82, Issue:4

    Topics: Amodiaquine; Animals; Chloroquine; Female; Humans; Malaria; Malawi; Placenta Diseases; Plasmodium fa

1988
[In vivo resistance of Plasmodium falciparum to 4-aminoquinolines and to a sulfadoxine-pyrimethamine combination. II. Study of Manaus, Amazonas 1983-1984].
    Revista brasileira de malariologia e doencas tropicais. Publicacoes avulsas, 1986, Volume: 38

    Topics: Adolescent; Adult; Amodiaquine; Animals; Brazil; Chloroquine; Clinical Trials as Topic; Drug Resista

1986
Amodiaquine and sulfadoxine-pyrimethamine as treatment for chloroquine-resistant Plasmodium falciparum in Rwanda.
    The American journal of tropical medicine and hygiene, 1988, Volume: 38, Issue:2

    Topics: Amodiaquine; Animals; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Female; Hum

1988
Evaluation of four therapeutic regimens for falciparum malaria in Mozambique, 1986.
    Bulletin of the World Health Organization, 1988, Volume: 66, Issue:2

    Topics: Amodiaquine; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Drug Therapy, Combination;

1988
Effects of chloroquine, amodiaquine and pyrimethamine-sulfadoxine on Plasmodium falciparum gametocytemia.
    The American journal of tropical medicine and hygiene, 1986, Volume: 35, Issue:2

    Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinatio

1986
Amodiaquine less effective than chloroquine in the treatment of falciparum malaria in the Philippines.
    The American journal of tropical medicine and hygiene, 1987, Volume: 36, Issue:1

    Topics: Adolescent; Adult; Amodiaquine; Biological Availability; Chloroquine; Clinical Trials as Topic; Drug

1987
Orally administered amodiaquine base suspensions in the treatment of acute malaria infections of young children in Nigeria.
    The Journal of tropical medicine and hygiene, 1974, Volume: 77, Issue:10

    Topics: Administration, Oral; Amodiaquine; Blood; Child; Child, Preschool; Chloroquine; Dose-Response Relati

1974
A trial of CI-564 (dapolar), a repository antimalarial for prophylaxis in Amapá, Brazil.
    The American journal of tropical medicine and hygiene, 1970, Volume: 19, Issue:3

    Topics: Acetanilides; Amodiaquine; Antimalarials; Brazil; Child; Child, Preschool; Clinical Trials as Topic;

1970
Prophylactic and sporontocidal treatment of chloroquine resistant Plasmodium falciparum from Malaya.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1970, Volume: 64, Issue:6

    Topics: Adult; Amodiaquine; Anopheles; Antimalarials; Blood; Chloroquine; Clinical Trials as Topic; Dapsone;

1970
The suppression of malaria with dapolar: a trial of 4-monthly doses in a village community in the Gambia, West Africa.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1971, Volume: 65, Issue:5

    Topics: Acetanilides; Adolescent; Adult; Age Factors; Amodiaquine; Antimalarials; Child; Child, Preschool; F

1971

Other Studies

313 other studies available for amodiaquine and Malaria

ArticleYear
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.
    Science (New York, N.Y.), 2011, Dec-09, Volume: 334, Issue:6061

    Topics: Animals; Antimalarials; Cell Line, Tumor; Drug Discovery; Drug Evaluation, Preclinical; Drug Resista

2011
Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium.
    Journal of medicinal chemistry, 2014, Nov-13, Volume: 57, Issue:21

    Topics: Animals; Antimalarials; Humans; Inhibitory Concentration 50; Malaria; Mice; Microsomes, Liver; Paras

2014
Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies.
    Bioorganic & medicinal chemistry, 2015, Sep-01, Volume: 23, Issue:17

    Topics: Aminoquinolines; Animals; Antimalarials; Benzene Derivatives; Humans; Malaria; Malaria, Falciparum;

2015
Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype.
    European journal of medicinal chemistry, 2015, Sep-18, Volume: 102

    Topics: Antimalarials; Cell Survival; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Indoles; Malar

2015
New hybrid trifluoromethylquinolines as antiplasmodium agents.
    Bioorganic & medicinal chemistry, 2019, 03-15, Volume: 27, Issue:6

    Topics: Animals; Antimalarials; Cell Line; Drug Discovery; Erythrocytes; Halogenation; Haplorhini; Humans; M

2019
Aminoalkoxycarbonyloxymethyl Ether Prodrugs with a pH-Triggered Release Mechanism: A Case Study Improving the Solubility, Bioavailability, and Efficacy of Antimalarial 4(1
    Journal of medicinal chemistry, 2021, 05-27, Volume: 64, Issue:10

    Topics: Administration, Oral; Animals; Antimalarials; Cyclization; Disease Models, Animal; Ethers; Female; H

2021
Trends and predictive factors for treatment failure following artemisinin-based combination therapy among children with uncomplicated malaria in Ghana: 2005-2018.
    BMC infectious diseases, 2021, Dec-15, Volume: 21, Issue:1

    Topics: Amodiaquine; Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artemisinins; Chi

2021
Effect of three years' seasonal malaria chemoprevention on molecular markers of resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine and amodiaquine in Ouelessebougou, Mali.
    Malaria journal, 2022, Feb-08, Volume: 21, Issue:1

    Topics: Amodiaquine; Antimalarials; Chemoprevention; Child; Child, Preschool; Cross-Sectional Studies; Drug

2022
Artesunate-amodiaquine and artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in Liberia: in vivo efficacy and frequency of molecular markers.
    Malaria journal, 2022, Apr-27, Volume: 21, Issue:1

    Topics: Amodiaquine; Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artesunate; Child

2022
Prevalence of malaria among febrile patients and assessment of efficacy of artemether-lumefantrine and artesunate-amodiaquine for uncomplicated malaria in Dolisie, Republic of the Congo.
    Malaria journal, 2022, May-02, Volume: 21, Issue:1

    Topics: Amodiaquine; Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artesunate; Child

2022
Stakeholder perceptions on the deployment of multiple first-line therapies for uncomplicated malaria: a qualitative study in the health district of Kaya, Burkina Faso.
    Malaria journal, 2022, Jun-27, Volume: 21, Issue:1

    Topics: Amodiaquine; Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artemisinins; Art

2022
A Decade of Progress Accelerating Malaria Control in Mali: Evidence from the West Africa International Center of Excellence for Malaria Research.
    The American journal of tropical medicine and hygiene, 2022, 10-11, Volume: 107, Issue:4_Suppl

    Topics: Amodiaquine; Antimalarials; Artemisinins; Child; Child, Preschool; Drug Combinations; Humans; Malari

2022
Cardiovascular concentration-effect relationships of amodiaquine and its metabolite desethylamodiaquine: Clinical and preclinical studies.
    British journal of clinical pharmacology, 2023, Volume: 89, Issue:3

    Topics: Amodiaquine; Animals; Antimalarials; Kenya; Malaria; Mice

2023
Prevalence of Plasmodium falciparum haplotypes associated with resistance to sulfadoxine-pyrimethamine and amodiaquine before and after upscaling of seasonal malaria chemoprevention in seven African countries: a genomic surveillance study.
    The Lancet. Infectious diseases, 2023, Volume: 23, Issue:3

    Topics: Amodiaquine; Antimalarials; Chemoprevention; Child; Drug Combinations; Drug Resistance; Genomics; Ha

2023
Design, Implementation, and Coordination of Malaria Therapeutic Efficacy Studies in Nigeria in 2018.
    The American journal of tropical medicine and hygiene, 2023, 06-07, Volume: 108, Issue:6

    Topics: Amodiaquine; Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Child; Drug Combi

2023
Predictors of caregiver adherence to administration of amodiaquine during delivery of seasonal malaria chemoprevention in Nigeria, Burkina Faso, Chad, and Togo.
    Malaria journal, 2023, May-05, Volume: 22, Issue:1

    Topics: Amodiaquine; Antimalarials; Burkina Faso; Caregivers; Chad; Chemoprevention; Child; Drug Combination

2023
Seasonal Malaria Chemoprevention Drug Levels and Drug Resistance Markers in Children With or Without Malaria in Burkina Faso: A Case-Control Study.
    The Journal of infectious diseases, 2023, 10-03, Volume: 228, Issue:7

    Topics: Amodiaquine; Antimalarials; Burkina Faso; Case-Control Studies; Chemoprevention; Child; Child, Presc

2023
Antimalarial Agents Derived from Metal-Amodiaquine Complexes with Activity in Multiple Stages of the Plasmodium Life Cycle.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2023, Oct-02, Volume: 29, Issue:55

    Topics: Amodiaquine; Antimalarials; Coordination Complexes; Humans; Malaria; Plasmodium; Plasmodium falcipar

2023
Effectiveness of seasonal malaria chemoprevention in reducing under-five malaria morbidity and mortality in the Savannah Region, Ghana.
    Ghana medical journal, 2022, Volume: 56, Issue:2

    Topics: Amodiaquine; Antimalarials; Chemoprevention; Child; Child, Preschool; Ghana; Humans; Infant; Malaria

2022
Variation in neutrophil levels and artemisinin-based combination therapy efficacy in West-Africa.
    Journal of infection in developing countries, 2023, 09-30, Volume: 17, Issue:9

    Topics: Africa; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesun

2023
Consequences of restricting antimalarial drugs to rapid diagnostic test-positive febrile children in south-west Nigeria.
    Tropical medicine & international health : TM & IH, 2019, Volume: 24, Issue:11

    Topics: Amodiaquine; Antimalarials; Artemisinins; Child, Preschool; Cross-Sectional Studies; Drug Combinatio

2019
Influence of MAMA decoction, an Herbal Antimalarial, on the Pharmacokinetics of Amodiaquine in Mice.
    European journal of drug metabolism and pharmacokinetics, 2020, Volume: 45, Issue:1

    Topics: Amodiaquine; Animals; Antimalarials; Drug Combinations; Drug Interactions; Female; Herb-Drug Interac

2020
Adherence and Population Pharmacokinetic Properties of Amodiaquine When Used for Seasonal Malaria Chemoprevention in African Children.
    Clinical pharmacology and therapeutics, 2020, Volume: 107, Issue:5

    Topics: Africa; Amodiaquine; Antimalarials; Case-Control Studies; Chemoprevention; Child, Preschool; Female;

2020
Optimal Approach and Strategies to Strengthen Pharmacovigilance in Sub-Saharan Africa: A Cohort Study of Patients Treated with First-Line Artemisinin-Based Combination Therapies in the Nanoro Health and Demographic Surveillance System, Burkina Faso.
    Drug design, development and therapy, 2020, Volume: 14

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemisinins; Burkina Faso; Child; Child, Preschool; Cohort

2020
The End of the Artemisinin Era-We Should Aim at Malaria Eradication in Asia Using Free, Effective Treatment.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021, 08-02, Volume: 73, Issue:3

    Topics: Amodiaquine; Artemisinins; Artesunate; Asia; Cambodia; Humans; Malaria; Plasmodium falciparum

2021
Clinical and In Vitro Resistance of Plasmodium falciparum to Artesunate-Amodiaquine in Cambodia.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021, 08-02, Volume: 73, Issue:3

    Topics: Adult; Amodiaquine; Antimalarials; Artemisinins; Artesunate; Asia; Cambodia; Child; Humans; Malaria;

2021
Serotype Profile of Nasopharyngeal Isolates of
    The American journal of tropical medicine and hygiene, 2020, Volume: 103, Issue:2

    Topics: Amodiaquine; Anti-Bacterial Agents; Antimalarials; Azithromycin; Burkina Faso; Carrier State; Chemop

2020
Increased Sensitivity of Plasmodium falciparum to Artesunate/Amodiaquine Despite 14 Years as First-Line Malaria Treatment, Zanzibar.
    Emerging infectious diseases, 2020, Volume: 26, Issue:8

    Topics: Amodiaquine; Antimalarials; Artesunate; Asia; Drug Combinations; Drug Resistance; Humans; Malaria; M

2020
Antimalarial artemisinin-based combination therapies (ACT) and COVID-19 in Africa: In vitro inhibition of SARS-CoV-2 replication by mefloquine-artesunate.
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2020, Volume: 99

    Topics: Amodiaquine; Animals; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Betaco

2020
Treatment Approved for Severe Malaria.
    The American journal of nursing, 2020, Volume: 120, Issue:9

    Topics: Adult; Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child; Drug Combinations; Drug Monitori

2020
Clinical Probe of Cyp2C8*2 Mutants in a Malaria Hyperendemic Zone: Evidence from North-Central, Nigeria.
    Acta medica (Hradec Kralove), 2020, Volume: 63, Issue:3

    Topics: Adult; Amodiaquine; Antimalarials; Artemisinins; Chloroquine; Cytochrome P-450 CYP2C8; Drug Resistan

2020
Effectiveness of seasonal malaria chemoprevention at scale in west and central Africa: an observational study.
    Lancet (London, England), 2020, 12-05, Volume: 396, Issue:10265

    Topics: Adolescent; Adult; Africa, Central; Africa, Western; Amodiaquine; Antimalarials; Case-Control Studie

2020
Effectiveness of seasonal malaria chemoprevention at scale in west and central Africa: an observational study.
    Lancet (London, England), 2020, 12-05, Volume: 396, Issue:10265

    Topics: Adolescent; Adult; Africa, Central; Africa, Western; Amodiaquine; Antimalarials; Case-Control Studie

2020
Effectiveness of seasonal malaria chemoprevention at scale in west and central Africa: an observational study.
    Lancet (London, England), 2020, 12-05, Volume: 396, Issue:10265

    Topics: Adolescent; Adult; Africa, Central; Africa, Western; Amodiaquine; Antimalarials; Case-Control Studie

2020
Effectiveness of seasonal malaria chemoprevention at scale in west and central Africa: an observational study.
    Lancet (London, England), 2020, 12-05, Volume: 396, Issue:10265

    Topics: Adolescent; Adult; Africa, Central; Africa, Western; Amodiaquine; Antimalarials; Case-Control Studie

2020
Assessment of antimalarial drug resistant markers in asymptomatic Plasmodium falciparum infections after 4 years of indoor residual spraying in Northern Ghana.
    PloS one, 2020, Volume: 15, Issue:12

    Topics: Amodiaquine; Antimalarials; Biomarkers, Pharmacological; Carrier State; Child, Preschool; Chloroquin

2020
Treatment of COVID-19 with Chloroquine: Implication for Malaria Chemotherapy Using ACTs in Disease Endemic Countries.
    Journal of tropical pediatrics, 2021, 01-29, Volume: 67, Issue:1

    Topics: Amodiaquine; Chloroquine; COVID-19 Drug Treatment; Drug Resistance; Humans; Malaria; Plasmodium

2021
Protocol for a quasi-experimental study to assess the feasibility, acceptability and costs of multiple first-lines artemisinin-based combination therapies for uncomplicated malaria in the Kaya health district, Burkina Faso.
    BMJ open, 2021, 02-15, Volume: 11, Issue:2

    Topics: Amodiaquine; Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artemisinins; Bur

2021
Cost-effectiveness of district-wide seasonal malaria chemoprevention when implemented through routine malaria control programme in Kita, Mali using fixed point distribution.
    Malaria journal, 2021, Mar-04, Volume: 20, Issue:1

    Topics: Amodiaquine; Antimalarials; Chemoprevention; Child, Preschool; Communicable Disease Control; Cost-Be

2021
Plasmodium falciparum Atg18 localizes to the food vacuole via interaction with the multi-drug resistance protein 1 and phosphatidylinositol 3-phosphate.
    The Biochemical journal, 2021, 05-14, Volume: 478, Issue:9

    Topics: Amodiaquine; Animals; Antimalarials; Autophagy; Autophagy-Related Proteins; Biological Transport; Ch

2021
Seasonal malaria chemoprevention in the Sahel.
    The Lancet. Infectious diseases, 2017, Volume: 17, Issue:6

    Topics: Africa; Amodiaquine; Antimalarials; Chemoprevention; Child, Preschool; Drug Combinations; Female; Hu

2017
Ex vivo susceptibility and genotyping of Plasmodium falciparum isolates from Pikine, Senegal.
    Malaria journal, 2017, 06-14, Volume: 16, Issue:1

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; DNA, Pro

2017
The Candidate Antimalarial Drug MMV665909 Causes Oxygen-Dependent mRNA Mistranslation and Synergizes with Quinoline-Derived Antimalarials.
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:9

    Topics: Amodiaquine; Antimalarials; Artemisinins; Chloroquine; Malaria; Oxygen; Primaquine; Protein Biosynth

2017
Study on testicular response to prolong artemisinin-based combination therapy treatments in guinea pigs.
    Andrologia, 2018, Volume: 50, Issue:2

    Topics: Amodiaquine; Animals; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Drug C

2018
Measuring the impact of seasonal malaria chemoprevention as part of routine malaria control in Kita, Mali.
    Malaria journal, 2017, 08-10, Volume: 16, Issue:1

    Topics: Amodiaquine; Anemia; Antimalarials; Chemoprevention; Child; Child, Preschool; Cross-Sectional Studie

2017
Large-scale delivery of seasonal malaria chemoprevention to children under 10 in Senegal: an economic analysis.
    Health policy and planning, 2017, Nov-01, Volume: 32, Issue:9

    Topics: Amodiaquine; Antimalarials; Chemoprevention; Child; Child, Preschool; Community Health Workers; Cost

2017
Seasonal malaria chemoprevention: successes and missed opportunities.
    Malaria journal, 2017, 11-28, Volume: 16, Issue:1

    Topics: Africa South of the Sahara; Amodiaquine; Antimalarials; Chemoprevention; Child, Preschool; Drug Comb

2017
Prescriber practices and patient adherence to artemisinin-based combination therapy for the treatment of uncomplicated malaria in Guinea, 2016.
    Malaria journal, 2019, Jan-25, Volume: 18, Issue:1

    Topics: Adolescent; Adult; Aged; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Arte

2019
Evaluation of the effects on the QT-interval of 4 artemisinin-based combination therapies with a correction-free and heart rate-free method.
    Scientific reports, 2019, 01-29, Volume: 9, Issue:1

    Topics: Adolescent; Amodiaquine; Antimalarials; Arrhythmias, Cardiac; Artemether; Artemether, Lumefantrine D

2019
Effect of Adding Azithromycin to Seasonal Malaria Chemoprevention.
    The New England journal of medicine, 2019, Jun-06, Volume: 380, Issue:23

    Topics: Amodiaquine; Anti-Bacterial Agents; Antimalarials; Azithromycin; Burkina Faso; Child Mortality; Chil

2019
Failures in the case management of children with uncomplicated malaria in Bata district of Equatorial Guinea and associated factors.
    PloS one, 2019, Volume: 14, Issue:8

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemisinins; Case Management; Child; Child, Preschool; Cros

2019
Should malaria treatment be guided by a point of care rapid test? A threshold approach to malaria management in rural Burkina Faso.
    PloS one, 2013, Volume: 8, Issue:3

    Topics: Adult; Amodiaquine; Antimalarials; Burkina Faso; Child, Preschool; Decision Making; Drug Combination

2013
Safety of Artemisinin-Based Combination Therapies in Nigeria: A Cohort Event Monitoring Study.
    Drug safety, 2013, Volume: 36, Issue:9

    Topics: Adolescent; Adult; Amodiaquine; Anti-Infective Agents; Antimalarials; Artemisinins; Child; Child, Pr

2013
Reversible binocular visual loss in temporal association with artesunate-amodiaquine treatment in a child on mefloquine chemoprophylaxis.
    Ghana medical journal, 2012, Volume: 46, Issue:3

    Topics: Amodiaquine; Anti-Inflammatory Agents; Antimalarials; Artemisinins; Chemoprevention; Child; Dexameth

2012
Disposition of amodiaquine and desethylamodiaquine in HIV-infected Nigerian subjects on nevirapine-containing antiretroviral therapy.
    The Journal of antimicrobial chemotherapy, 2014, Volume: 69, Issue:5

    Topics: Adolescent; Adult; Amodiaquine; Anti-Retroviral Agents; Antimalarials; Antiretroviral Therapy, Highl

2014
Suppressive action of mepacrine, aphacrine, chloroquin, camoquin and proguanil against P. knowlesi in S. rhesus monkeys.
    Indian journal of malariology, 1950, Volume: 4, Issue:1

    Topics: Amodiaquine; Animals; Chloroquine; Humans; Macaca mulatta; Malaria; Proguanil; Quinacrine

1950
Comparison of the action of paludrine (proguanil), chloroquine and camoquin in single doses.
    Indian journal of malariology, 1950, Volume: 4, Issue:2

    Topics: Amodiaquine; Chloroquine; Humans; Malaria; Proguanil

1950
Camoquin and chloroquine in the treatment of malaria.
    Indian journal of malariology, 1950, Volume: 4, Issue:2

    Topics: Amodiaquine; Chloroquine; Humans; Malaria

1950
Needs-driven versus market-driven pharmaceutical innovation: the consortium for the development of a new medicine against malaria in Brazil.
    Developing world bioethics, 2014, Volume: 14, Issue:2

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Brazil; Drug Combinations; Drug Discovery; Dru

2014
Interaction between rifampicin, amodiaquine and artemether in mice infected with chloroquine resistant Plasmodium berghei.
    Malaria journal, 2014, Aug-05, Volume: 13

    Topics: Amodiaquine; Animals; Antimalarials; Artemether; Artemisinins; Drug Interactions; Drug Resistance; D

2014
Amodiaquine-Ciprofloxacin: a potential combination therapy against drug resistant malaria.
    Parasitology, 2015, Volume: 142, Issue:6

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Ciprofloxacin; Dose-Response Relationship, Drug; D

2015
The implication of long-lasting insecticide-treated net use in the resurgence of malaria morbidity in a Senegal malaria endemic village in 2010-2011.
    Parasites & vectors, 2015, May-13, Volume: 8

    Topics: Adolescent; Adult; Amodiaquine; Animals; Artemisinins; Child; Child, Preschool; Cross-Sectional Stud

2015
High adherence to malaria treatment: promising results of an adherence study in South Kivu, Democratic Republic of the Congo.
    Malaria journal, 2015, Oct-19, Volume: 14

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amodiaquine; Animals; Antimalarials; Artemisinins; Child

2015
Therapeutic efficacy of artesunate-amodiaquine and artemether-lumefantrine combinations in the treatment of uncomplicated malaria in two ecological zones in Ghana.
    Malaria journal, 2016, Jan-05, Volume: 15

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Drug Combinations; Ec

2016
Effect of Artesunate-Amodiaquine on Mortality Related to Ebola Virus Disease.
    The New England journal of medicine, 2016, Jan-07, Volume: 374, Issue:1

    Topics: Adolescent; Adult; Amodiaquine; Anti-Bacterial Agents; Antimalarials; Artemether, Lumefantrine Drug

2016
Seeking treatment for uncomplicated malaria: experiences from the Kintampo districts of Ghana.
    Malaria journal, 2016, Feb-20, Volume: 15

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amodiaquine; Antimalarials; Artemether, Lumefantrine Dru

2016
Lopinavir/ritonavir enhanced the antimalarial activity of amodiaquine and artesunate in a mouse model of Plasmodium berghei.
    Journal of chemotherapy (Florence, Italy), 2016, Volume: 28, Issue:6

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Artesunate; Disease Models, Animal; Drug Synergis

2016
Evaluation of herbal antimalarial MAMA decoction-amodiaquine combination in murine malaria model.
    Pharmaceutical biology, 2016, Volume: 54, Issue:10

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Resistance; Drug Ther

2016
Evaluation of the combination of Uvaria chamae (P. Beauv.) and amodiaquine in murine malaria.
    Journal of ethnopharmacology, 2016, Dec-04, Volume: 193

    Topics: Amodiaquine; Animals; Antimalarials; Herb-Drug Interactions; Malaria; Mice; Plant Preparations; Plas

2016
Adherence to malaria diagnosis and treatment guidelines among healthcare workers in Ogun State, Nigeria.
    BMC public health, 2016, 08-19, Volume: 16, Issue:1

    Topics: Adult; Amodiaquine; Antimalarials; Artemisinins; Artesunate; Case Management; Cross-Sectional Studie

2016
Busting the billion-dollar myth: how to slash the cost of drug development.
    Nature, 2016, 08-25, Volume: 536, Issue:7617

    Topics: Africa; Amodiaquine; Anti-Bacterial Agents; Artemisinins; Benzamides; Boron Compounds; Child; Clinic

2016
Impact of the Mass Drug Administration for malaria in response to the Ebola outbreak in Sierra Leone.
    Malaria journal, 2016, Sep-20, Volume: 15

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amodiaquine; Antimalarials; Artemisinins; Child; Child,

2016
Molecular surveillance of Plasmodium falciparum drug resistance markers reveals partial recovery of chloroquine susceptibility but sustained sulfadoxine-pyrimethamine resistance at two sites of different malaria transmission intensities in Rwanda.
    Acta tropica, 2016, Volume: 164

    Topics: Adolescent; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Dru

2016
Impact of Extended Duration of Artesunate Treatment on Parasitological Outcome in a Cytocidal Murine Malaria Model.
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:4

    Topics: Amodiaquine; Animals; Antimalarials; Artemether; Artemisinins; Artesunate; Disease Models, Animal; F

2017
Intermittent preventive antimalarial treatment to children (IPTc): firebreak or fire trap?
    Trends in parasitology, 2008, Volume: 24, Issue:11

    Topics: Amodiaquine; Antimalarials; Artemisinins; Child, Preschool; Decision Making; Drug Administration Sch

2008
Effectiveness of artemisinin-based combination therapy used in the context of home management of malaria: a report from three study sites in sub-Saharan Africa.
    Malaria journal, 2008, Sep-27, Volume: 7

    Topics: Africa South of the Sahara; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; A

2008
Trends in malaria morbidity following the introduction of artesunate plus amodiaquine combination in M'lomp village dispensary, south-western Senegal.
    Malaria journal, 2008, Oct-24, Volume: 7

    Topics: Adolescent; Amodiaquine; Animals; Antimalarials; Artemisinins; Child; Child, Preschool; Drug Combina

2008
[Two cases of fulminant hepatitis during a curative treatment with an artesunate-amodiaquine combination].
    Medecine et maladies infectieuses, 2009, Volume: 39, Issue:1

    Topics: Adult; Amodiaquine; Antimalarials; Artemisinins; Artesunate; Chemical and Drug Induced Liver Injury;

2009
Efficacy of monotherapies and artesunate-based combination therapies in children with uncomplicated malaria in Somalia.
    Acta tropica, 2009, Volume: 109, Issue:2

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; Drug Com

2009
Biological measure of compliance to Artesunate plus Amodiaquine association: interest in a Mono-Desethyl-Amodiaquine blood assay?
    Acta tropica, 2009, Volume: 110, Issue:1

    Topics: Adult; Amodiaquine; Animals; Antimalarials; Artemisinins; Chromatography, High Pressure Liquid; Drug

2009
Intermittent preventive treatment with antimalarial drugs.
    Lancet (London, England), 2009, Jan-03, Volume: 373, Issue:9657

    Topics: Amodiaquine; Anemia; Antimalarials; Drug Administration Schedule; Drug Combinations; Humans; Infant;

2009
Pattern of drug utilization for treatment of uncomplicated malaria in urban Ghana following national treatment policy change to artemisinin-combination therapy.
    Malaria journal, 2009, Jan-05, Volume: 8

    Topics: Adolescent; Adult; Aged; Amodiaquine; Animals; Antimalarials; Artemisinins; Child; Child, Preschool;

2009
Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.
    Journal of medicinal chemistry, 2009, Mar-12, Volume: 52, Issue:5

    Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Benzylamines; Cytochrome P-450 Enzyme Inhibito

2009
Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.
    Journal of medicinal chemistry, 2009, Apr-09, Volume: 52, Issue:7

    Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Cell Survival; Chloroquine; Dogs; Drug Resista

2009
Plasmodium berghei ANKA: selection of resistance to piperaquine and lumefantrine in a mouse model.
    Experimental parasitology, 2009, Volume: 122, Issue:3

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Chloroquine; Disease Models, Animal; Drug Resista

2009
In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa.
    The Journal of infectious diseases, 2009, Jun-01, Volume: 199, Issue:11

    Topics: Amodiaquine; Animals; Antimalarials; Child, Preschool; Cohort Studies; Female; Humans; Infant; Kenya

2009
Factors related to compliance to anti-malarial drug combination: example of amodiaquine/sulphadoxine-pyrimethamine among children in rural Senegal.
    Malaria journal, 2009, Jun-04, Volume: 8

    Topics: Amodiaquine; Animals; Antimalarials; Caregivers; Child; Child, Preschool; Drug Administration Schedu

2009
Treatment of malaria from monotherapy to artemisinin-based combination therapy by health professionals in rural health facilities in southern Cameroon.
    Malaria journal, 2009, Jul-29, Volume: 8

    Topics: Adult; Aged; Amodiaquine; Antimalarials; Artemisinins; Cameroon; Child, Preschool; Drug Combinations

2009
Treatment of malaria from monotherapy to artemisinin-based combination therapy by health professionals in urban health facilities in Yaoundé, central province, Cameroon.
    Malaria journal, 2009, Jul-29, Volume: 8

    Topics: Adult; Aged; Aged, 80 and over; Amodiaquine; Antimalarials; Artemisinins; Cameroon; Child, Preschool

2009
Mode of action and choice of antimalarial drugs for intermittent preventive treatment in infants.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 2009, Volume: 103, Issue:12

    Topics: Amodiaquine; Antimalarials; Clinical Trials as Topic; Drug Combinations; Drug Resistance; Female; Hu

2009
Self-reported data: a major tool to assess compliance with anti-malarial combination therapy among children in Senegal.
    Malaria journal, 2009, Nov-17, Volume: 8

    Topics: Amodiaquine; Antimalarials; Caregivers; Child; Child, Preschool; Drug Administration Schedule; Drug

2009
Successful introduction of artesunate combination therapy is not enough to fight malaria: results from an adherence study in Sierra Leone.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 2010, Volume: 104, Issue:5

    Topics: Adolescent; Adult; Aged; Amodiaquine; Antimalarials; Artemisinins; Artesunate; Caregivers; Child; Ch

2010
Intermittent preventive treatment to reduce the burden of malaria in children: new evidence on integration and delivery.
    PLoS medicine, 2011, Feb-01, Volume: 8, Issue:2

    Topics: Amodiaquine; Antimalarials; Child, Preschool; Drug Combinations; Female; Humans; Infant; Infant, New

2011
Two-year evaluation of Intermittent Preventive Treatment for Children (IPTc) combined with timely home treatment for malaria control in Ghana.
    Malaria journal, 2011, May-15, Volume: 10

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Chemoprevention; Child, Preschool; Drug Combinati

2011
Two-year evaluation of Intermittent Preventive Treatment for Children (IPTc) combined with timely home treatment for malaria control in Ghana.
    Malaria journal, 2011, May-15, Volume: 10

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Chemoprevention; Child, Preschool; Drug Combinati

2011
Two-year evaluation of Intermittent Preventive Treatment for Children (IPTc) combined with timely home treatment for malaria control in Ghana.
    Malaria journal, 2011, May-15, Volume: 10

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Chemoprevention; Child, Preschool; Drug Combinati

2011
Two-year evaluation of Intermittent Preventive Treatment for Children (IPTc) combined with timely home treatment for malaria control in Ghana.
    Malaria journal, 2011, May-15, Volume: 10

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Chemoprevention; Child, Preschool; Drug Combinati

2011
The initial pharmaceutical development of an artesunate/amodiaquine oral formulation for the treatment of malaria: a public-private partnership.
    Malaria journal, 2011, May-23, Volume: 10

    Topics: Amodiaquine; Antimalarials; Artemisinins; Chemistry, Pharmaceutical; Drug Combinations; Humans; Mala

2011
Innovative public-private partnerships to maximize the delivery of anti-malarial medicines: lessons learned from the ASAQ Winthrop experience.
    Malaria journal, 2011, May-23, Volume: 10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amodiaquine; Antimalarials; Artemisinins; Case-Control S

2011
Antimalarial mannoxanes: hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action.
    ChemMedChem, 2011, Aug-01, Volume: 6, Issue:8

    Topics: Administration, Oral; Amodiaquine; Animals; Antimalarials; Hemeproteins; Hemin; Humans; Malaria; Man

2011
Changing patterns of malaria during 1996-2010 in an area of moderate transmission in southern Senegal.
    Malaria journal, 2011, Jul-25, Volume: 10

    Topics: Adolescent; Adult; Aged; Amodiaquine; Antimalarials; Artemisinins; Child; Child, Preschool; Drug Com

2011
Management of uncomplicated malaria in children under 13 years of age at a district hospital in Senegal: from official guidelines to usual practices.
    Malaria journal, 2011, Sep-29, Volume: 10

    Topics: Adolescent; Amodiaquine; Antimalarials; Blood; Child; Child, Preschool; Drug Combinations; Drug Ther

2011
A thirteen-year analysis of Plasmodium falciparum populations reveals high conservation of the mutant pfcrt haplotype despite the withdrawal of chloroquine from national treatment guidelines in Gabon.
    Malaria journal, 2011, Oct-17, Volume: 10

    Topics: Amodiaquine; Antimalarials; Artemisinins; Chloroquine; DNA, Protozoan; Drug Combinations; Drug Resis

2011
Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Nov-22, Volume: 108, Issue:47

    Topics: Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Blotting, Southern; Dose-Response Rela

2011
Assessing the consistency assumption by exploring treatment by covariate interactions in mixed treatment comparison meta-analysis: individual patient-level covariates versus aggregate trial-level covariates.
    Statistics in medicine, 2012, Dec-20, Volume: 31, Issue:29

    Topics: Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Dap

2012
Access to artemisinin-combination therapy (ACT) and other anti-malarials: national policy and markets in Sierra Leone.
    PloS one, 2012, Volume: 7, Issue:10

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Drug Costs; Geography; Health Policy; Health S

2012
Anti-malarial drug safety information obtained through routine monitoring in a rural district of South-Western Senegal.
    Malaria journal, 2012, Dec-05, Volume: 11

    Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Amodiaquine; Antimalarials; Artemisinins

2012
Questions about the antimalarial amodiaquine.
    Lancet (London, England), 2003, Apr-05, Volume: 361, Issue:9364

    Topics: Amodiaquine; Antimalarials; Humans; Malaria; Neutropenia

2003
Vendor-to-vendor education to improve malaria treatment by private drug outlets in Bungoma District, Kenya.
    Malaria journal, 2003, May-07, Volume: 2

    Topics: Adult; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Commerce; Drug Combinations

2003
Evaluation of amodiaquin (camoquin) in the treatment of relapsing vivax malaria.
    The American journal of the medical sciences, 1953, Volume: 225, Issue:1

    Topics: Amodiaquine; Malaria; Malaria, Vivax; Recurrence

1953
Clinical trials with Camoquin in malaria.
    The Journal of tropical medicine and hygiene, 1952, Volume: 55, Issue:10

    Topics: Amodiaquine; Humans; Malaria

1952
[Malaria prevention by amodiaquine].
    Annales de la Societe belge de medecine tropicale (1920), 1952, Dec-31, Volume: 32, Issue:5

    Topics: Amodiaquine; Humans; Malaria

1952
[Use of camoquine in treatment of malaria].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1952, Volume: 45, Issue:6

    Topics: Amodiaquine; Humans; Malaria

1952
Treatment of sub-tertian malaria with camoquin.
    East African medical journal, 1952, Volume: 29, Issue:12

    Topics: Amodiaquine; Humans; Malaria

1952
Screening of antimalarials against P. gallinaceum in chicks.
    Indian journal of malariology, 1952, Volume: 6, Issue:2

    Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Chickens; Chloroquine; Malaria; Proguanil; Qui

1952
Camoquin in malaria.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1953, Jan-31, Volume: 27, Issue:5

    Topics: Amodiaquine; Humans; Malaria

1953
[Results of experiences with chloroquine, proguanil and amodiaquine in the prophylaxis of malaria].
    Anais do Instituto de Medicina Tropical, 1952, Volume: 9, Issue:2

    Topics: Amodiaquine; Chloroquine; Humans; Malaria; Proguanil

1952
Suppressive treatment with amodiaquin.
    Indian journal of malariology, 1953, Volume: 7, Issue:1

    Topics: Amodiaquine; Antimalarials; Humans; Malaria

1953
A comparison of the antimalarial effects of suppressive doses of chloroquine, amodiaquin, and pyrimethamine.
    The American journal of tropical medicine and hygiene, 1954, Volume: 3, Issue:3

    Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Malaria; Pyrimethamine

1954
Nivaquine and camoquin in malaria.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1954, May-01, Volume: 28, Issue:18

    Topics: Amodiaquine; Antimalarials; Chloroquine; Malaria; Quinolines

1954
[Treatment of some forms of malaria with flavoquine; 201 observations].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1954, Volume: 47, Issue:1

    Topics: Amodiaquine; Antimalarials; Humans; Malaria

1954
[Medicinal prophylaxis of malaria by monthly doses of chloroquine and amodiaquine].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1954, Volume: 47, Issue:2

    Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Malaria

1954
A note on clinical trial of pyrimethamine (daraprim) and amodiaquin (camaquin) at the malaria field station, Thirmalapur, Nizamabad district.
    Indian journal of malariology, 1953, Volume: 7, Issue:4

    Topics: Amodiaquine; Antimalarials; Malaria; Pyrimethamine

1953
Therapeutic trials with pyrimethamine (daraprim), resochin, amodiaquin (camoquin) and quinine.
    Indian journal of malariology, 1953, Volume: 7, Issue:4

    Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Malaria; Pyrimethamine; Quinine

1953
The treatment of acute malaria with single oral doses of amodiaquin, chloroquine, hydroxychloroquine and pyrimethamine.
    The American journal of tropical medicine and hygiene, 1954, Volume: 3, Issue:5

    Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Hydroxychloroquine; Malaria; Pyrimethamine

1954
Treatment of malaria with a single dose of amodiaquin (Camoquin).
    Indian journal of malariology, 1954, Volume: 8, Issue:1

    Topics: Amodiaquine; Antimalarials; Malaria

1954
Camoquin as a malaria suppressant.
    The Journal of tropical medicine and hygiene, 1955, Volume: 58, Issue:7

    Topics: Amodiaquine; Antimalarials; Malaria

1955
Potentialities of monthly doses of camoquin and a gametocidal drug in malaria control.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1955, Volume: 49, Issue:4

    Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Malaria

1955
Studies on the chemotherapy of malaria. IV. The treatment of acute malaria with amodiaquin (camoquin).
    The Medical journal of Malaya, 1955, Volume: 9, Issue:4

    Topics: Amodiaquine; Antimalarials; Malaria

1955
Studies on the chemotherapy of malaria. V. The suppression of malaria by amodiaquin (camoquin).
    The Medical journal of Malaya, 1955, Volume: 9, Issue:4

    Topics: Amodiaquine; Antimalarials; Malaria

1955
Treatment on malaria with single doses of mepacrine, chloroquine and amodiaquin.
    The West African medical journal, 1955, Volume: 4, Issue:3

    Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Malaria; Quinacrine

1955
Comparative assessment of chloroquine and amodiaquine as malaria suppressives in Nigeria.
    Annals of tropical medicine and parasitology, 1958, Volume: 52, Issue:1

    Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Malaria; Nigeria

1958
[4-Aminoquinolines in eradication of malaria; epidemiologic evaluation of a single or double dose of 600 milligrams of camoquin].
    Rivista di malariologia, 1958, Volume: 37, Issue:4-6

    Topics: Aminoquinolines; Amodiaquine; Antimalarials; Humans; Malaria

1958
Single dose treatment of malaria with amodiaquin chloroquine and mepacrine in a semi-immune poplation.
    East African medical journal, 1960, Volume: 37

    Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Malaria; Quinacrine

1960
Amodiaquine and hydroxychloroquine resistance in Plasmodium falciparum.
    The American journal of tropical medicine and hygiene, 1961, Volume: 10

    Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Hydroxychloroquine; Malaria; Plasmodium falciparum

1961
Pigmentation of the nail-beds, palate and skin occurring during malarial suppressive therapy with "camoquin".
    The Medical journal of Australia, 1960, Jun-18, Volume: 47(1)

    Topics: Amodiaquine; Antimalarials; Humans; Malaria; Nails; Palate; Pigmentation; Pigmentation Disorders; Sk

1960
Mass administration of an antimalarial drug combining 4-aminoquinoline and 8-aminoquinoline in Tanganyika.
    Bulletin of the World Health Organization, 1962, Volume: 27

    Topics: Africa; Aminoquinolines; Amodiaquine; Animals; Antimalarials; Culicidae; Humans; Malaria; Primaquine

1962
FLUORESCENT ANTIBODY STUDIES IN HUMAN MALARIA. II. DEVELOPMENT AND PERSISTENCE OF ANTIBODIES TO PLASMODIUM FALCIPARUM.
    The American journal of tropical medicine and hygiene, 1964, Volume: 13

    Topics: Amodiaquine; Antibodies; Antigen-Antibody Reactions; Chloroquine; Fluorescent Antibody Technique; Hu

1964
STUDIES ON A STRAIN OF CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM FROM THAILAND.
    Bulletin of the World Health Organization, 1964, Volume: 30

    Topics: Amodiaquine; Antimalarials; Asia, Southeastern; Biomedical Research; Chloroquine; Drug Resistance; D

1964
[A PATIENT WITH TROPICAL MALARIA].
    Nederlands tijdschrift voor geneeskunde, 1964, Jan-18, Volume: 108

    Topics: Amodiaquine; Antimalarials; Chloroquine; Dosage Forms; Drug Resistance; Drug Resistance, Microbial;

1964
STUDIES ON A STRAIN OF CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM FROM VIET-NAM.
    Bulletin of the World Health Organization, 1964, Volume: 31

    Topics: Amodiaquine; Antimalarials; Biomedical Research; Chloroquine; Drug Therapy; Humans; Malaria; Malaria

1964
MALARIA IN CHILDHOOD MODERN CONCEPTS OF IMMUNITY, TREATMENT, PROPHYLAXIS.
    Clinical pediatrics, 1965, Volume: 4

    Topics: Amodiaquine; Child; Chloroquine; Diagnosis; Drug Therapy; Epidemiology; Humans; Infant; Infant, Newb

1965
SOME FEATURES OF MALARIA IN DILI, PORTUGUESE TIMOR, DURING 1963-64.
    Annals of tropical medicine and parasitology, 1965, Volume: 59

    Topics: Amodiaquine; Anemia; Chloroquine; Clinical Laboratory Techniques; Drug Therapy; Epidemiology; Humans

1965
Field trials of nivaquine, camoquin and resochin against human malaria.
    Indian journal of malariology, 1954, Volume: 8, Issue:3

    Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Malaria; Quinolines; Uricosuric Agents

1954
[Malaria prevention trial with amodiaquine on the Thuan-Loi plantation].
    Bulletin mensuel - Societe de medecine militaire francaise, 1955, Volume: 49, Issue:2

    Topics: Amodiaquine; Antimalarials; Biomedical Research; Humans; Malaria

1955
The efficacy of antimalarial monotherapies, sulphadoxine-pyrimethamine and amodiaquine in East Africa: implications for sub-regional policy.
    Tropical medicine & international health : TM & IH, 2003, Volume: 8, Issue:10

    Topics: Africa, Eastern; Amodiaquine; Antimalarials; Chloroquine; Disease Susceptibility; Drug Combinations;

2003
Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials.
    Journal of medicinal chemistry, 2003, Nov-06, Volume: 46, Issue:23

    Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Crystallography, X-Ray; Malaria; Male; Plasmod

2003
[Synthetic antimalarials; camoquin].
    La Medicina colonial, 1950, Volume: 16, Issue:3

    Topics: Amodiaquine; Antimalarials; Malaria; Quinolines

1950
[Treatment of malaria with camoquin].
    Revista brasileira de medicina, 1950, Volume: 7, Issue:9

    Topics: Amodiaquine; Humans; Malaria; Quinolines

1950
The treatment of malaria with a single dose of camoquin.
    The American journal of tropical medicine and hygiene, 1951, Volume: 31, Issue:1

    Topics: Amodiaquine; Malaria

1951
Camoquin in the treatment of human malaria.
    The American journal of tropical medicine and hygiene, 1951, Volume: 31, Issue:2

    Topics: Amodiaquine; Malaria

1951
[General sketch on documentation relative to amodiaquine].
    Bulletin of the World Health Organization, 1951, Volume: 4, Issue:2

    Topics: Amodiaquine; Documentation; Humans; Malaria; Quinolines

1951
Camoquin in malaria.
    The Indian medical gazette, 1951, Volume: 86, Issue:7

    Topics: Amodiaquine; Malaria

1951
Intravenous amodiaquin (camoquin) in naturally acquired and induced malaria.
    The American journal of tropical medicine and hygiene, 1951, Volume: 31, Issue:6

    Topics: Amodiaquine; Malaria

1951
[Flavoquine in the treatment of malaria].
    Algerie medicale, 1951, Volume: 55, Issue:10

    Topics: Amodiaquine; Humans; Malaria

1951
Treatment of malaria with a single dose of amodiaquine or chloroquine.
    Journal of the American Medical Association, 1952, Aug-09, Volume: 149, Issue:15

    Topics: Amodiaquine; Chloroquine; Humans; Malaria

1952
The anomalous antimalarial activity of O-methyl camoquin.
    Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1949, Volume: 38, Issue:12

    Topics: Amodiaquine; Antimalarials; Humans; Malaria

1949
Camoquin treatment of malaria a preliminary report.
    The American journal of tropical medicine and hygiene, 1950, Volume: 30, Issue:1

    Topics: Amodiaquine; Humans; Malaria; Quinolines

1950
Amodiaquine during pregnancy.
    The Lancet. Infectious diseases, 2004, Volume: 4, Issue:12

    Topics: Adult; Amodiaquine; Antimalarials; Artemisinins; Drug Therapy, Combination; Female; Humans; Malaria;

2004
New malaria combination cheaper and easier to take.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2005, Jun-07, Volume: 172, Issue:12

    Topics: Administration, Oral; Amodiaquine; Artemisinins; Artesunate; Drug Costs; Drug Therapy, Combination;

2005
Efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, chloroquine-sulfadoxine-pyrimethamine combination, and amodiaquine-sulfadoxine-pyrimethamine combination in Central African children with noncomplicated malaria.
    The American journal of tropical medicine and hygiene, 2005, Volume: 72, Issue:5

    Topics: Amodiaquine; Antimalarials; Central African Republic; Child, Preschool; Chloroquine; Drug Combinatio

2005
Amodiaquine and combination chemotherapy for malaria.
    The American journal of tropical medicine and hygiene, 2005, Volume: 73, Issue:5

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Drug Combinations; Drug Therapy, Combination; Hum

2005
Amodiaquine polymeric membrane electrode.
    Journal of pharmaceutical and biomedical analysis, 2006, Apr-11, Volume: 41, Issue:1

    Topics: Adipates; Amodiaquine; Antimalarials; Chemistry, Pharmaceutical; Diethylhexyl Phthalate; Electrodes;

2006
Factors contributing to the development of anaemia in Plasmodium falciparum malaria: what about drug-resistant parasites?
    Journal of tropical pediatrics, 2006, Volume: 52, Issue:4

    Topics: Amodiaquine; Anemia; Animals; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; Drug R

2006
Methodological issues in the assessment of antimalarial drug treatment: analysis of 13 studies in eight African countries from 2001 to 2004.
    Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:11

    Topics: Africa; Amodiaquine; Antimalarials; Child, Preschool; Chloroquine; Clinical Trials as Topic; Drug Co

2006
Cost-effectiveness study of three antimalarial drug combinations in Tanzania.
    PLoS medicine, 2006, Volume: 3, Issue:10

    Topics: Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Child, Preschoo

2006
Amodiaquine, malaria, pregnancy: the old new drug.
    Lancet (London, England), 2006, Oct-14, Volume: 368, Issue:9544

    Topics: Amodiaquine; Antimalarials; Drug Combinations; Drug Therapy, Combination; Female; Ghana; Humans; Mal

2006
[Against malaria: ASAQ, one dollar per box].
    Revue medicale suisse, 2007, Mar-14, Volume: 3, Issue:102

    Topics: Amodiaquine; Artemisinins; Costs and Cost Analysis; Drug Combinations; Humans; Malaria

2007
Antimalarial drugs--here and on the horizon.
    JAMA, 2007, May-23, Volume: 297, Issue:20

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Aspartic Acid Endopeptidases; Drug Combinations;

2007
Emergency liver transplantation in amodiaquine-induced fulminant hepatitis.
    The American journal of tropical medicine and hygiene, 2007, Volume: 77, Issue:1

    Topics: Adult; Amodiaquine; Antimalarials; Chemical and Drug Induced Liver Injury; Diagnosis, Differential;

2007
Community coverage of an antimalarial combination of artesunate and amodiaquine in Makamba Province, Burundi, nine months after its introduction.
    Malaria journal, 2007, Jul-18, Volume: 6

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Burundi; Child, Preschool; Community Health Se

2007
[ASAQ, a breakthrough in the fight against malaria].
    Medecine tropicale : revue du Corps de sante colonial, 2007, Volume: 67, Issue:2

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Drug Combinations; Drug Industry; Humans; Inte

2007
Pharmacologic advances in the global control and treatment of malaria: combination therapy and resistance.
    Clinical pharmacology and therapeutics, 2007, Volume: 82, Issue:5

    Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Dapsone; Drug Design;

2007
Clinical symptoms, treatment and outcome of highlands malaria in Eldoret (2420 m a.s.l.) and comparison to malaria in hyper-immune population in endemic region of Southern Sudan.
    Neuro endocrinology letters, 2007, Volume: 28 Suppl 3

    Topics: Altitude; Amodiaquine; Antimalarials; Artemisinins; Artesunate; Drug Therapy, Combination; Endemic D

2007
[Assessing the application of Rwanda's national protocol for uncomplicated malaria treatment in healthcare institutions in Kigali City, Rwanda].
    Medecine et maladies infectieuses, 2008, Volume: 38, Issue:3

    Topics: Adult; Amodiaquine; Antimalarials; Drug Prescriptions; Drug Therapy, Combination; Female; Guideline

2008
Parenteral use of camoquin hydrochloride as an antimalarial.
    The American journal of tropical medicine and hygiene, 1949, Volume: 29, Issue:3

    Topics: Amodiaquine; Antimalarials; Malaria

1949
A simple technique for the detection of anti-malarial drug formulations and their presence in human urine.
    Tanzania health research bulletin, 2006, Volume: 8, Issue:3

    Topics: Amodiaquine; Antimalarials; Biological Assay; Biological Availability; Chloroquine; Chromatography,

2006
Pharmacokinetic determinants of the window of selection for antimalarial drug resistance.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5

    Topics: Algorithms; Amodiaquine; Animals; Antimalarials; Artemisinins; Chloroquine; Computer Simulation; Dru

2008
Increased Plasmodium falciparum gametocyte production in mixed infections with P. malariae.
    The American journal of tropical medicine and hygiene, 2008, Volume: 78, Issue:3

    Topics: Amodiaquine; Animals; Antimalarials; Child; Drug Combinations; Gametogenesis; Humans; Malaria; Plasm

2008
Disease and drug interactions: treating malaria with artesunate plus amodiaquine in patients also receiving treatment for concomitant HIV infection.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2008, Apr-01, Volume: 46, Issue:7

    Topics: Amodiaquine; Anti-HIV Agents; Antimalarials; Artemisinins; Artesunate; Drug Interactions; Drug Thera

2008
Malaria control and primary health care.
    Lancet (London, England), 1983, Sep-17, Volume: 2, Issue:8351

    Topics: Amodiaquine; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Papua New Guinea; Plasmodium

1983
Amodiaquine and chloroquine efficacy against Plasmodium falciparum in Madagascar.
    Lancet (London, England), 1984, Jun-09, Volume: 1, Issue:8389

    Topics: Amodiaquine; Chloroquine; Humans; Madagascar; Malaria; Plasmodium falciparum

1984
Treatment of Plasmodium falciparum malaria with a combination of amodiaquine and tetracycline in Central Thailand.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1983, Volume: 77, Issue:3

    Topics: Adolescent; Adult; Aged; Amodiaquine; Drug Therapy, Combination; Female; Humans; Malaria; Male; Midd

1983
Plasmodium falciparum in Kisumu, Kenya: differences in sensitivity to amodiaquine and chloroquine in vitro.
    The Journal of infectious diseases, 1983, Volume: 148, Issue:4

    Topics: Amodiaquine; Child; Chloroquine; Drug Resistance, Microbial; Female; Humans; Kenya; Malaria; Male; M

1983
Evaluation of amodiaquine treatment of chloroquine-resistant Plasmodium falciparum malaria on Zanzibar, 1982.
    The American journal of tropical medicine and hygiene, 1983, Volume: 32, Issue:6

    Topics: Amodiaquine; Child; Child, Preschool; Chloroquine; Drug Evaluation; Drug Resistance; Humans; Infant;

1983
Treatment of chloroquine-resistant Plasmodium falciparum malaria.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1984, Jun-09, Volume: 65, Issue:23

    Topics: Amodiaquine; Chloroquine; Drug Resistance; Drug Therapy, Combination; Humans; Malaria; Plasmodium fa

1984
The sensitivity of Plasmodium falciparum to chloroquine and amodiaquine in Ibadan, Nigeria.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1984, Volume: 78, Issue:6

    Topics: Amodiaquine; Child; Child, Preschool; Chloroquine; Female; Humans; Infant; Malaria; Male; Microbial

1984
[4-Aminoquinoline-sensitivity of Plasmodium falciparum in Madagascar. I. Study in two regions of the west coast].
    Archives de l'Institut Pasteur de Madagascar, 1984, Volume: 51, Issue:1

    Topics: Adolescent; Aged; Aminoquinolines; Amodiaquine; Animals; Antimalarials; Child; Chloroquine; Drug Res

1984
[4-Aminoquinoline-sensitivity of Plasmodium falciparum in Madagascar. II. Study in two regions of the east coast].
    Archives de l'Institut Pasteur de Madagascar, 1984, Volume: 51, Issue:1

    Topics: Aminoquinolines; Amodiaquine; Antimalarials; Child; Chloroquine; Drug Resistance, Microbial; Humans;

1984
[4-Aminoquinoline-sensitivity of Plasmodium falciparum in Madagascar. III. Studies in three regions of the interior].
    Archives de l'Institut Pasteur de Madagascar, 1984, Volume: 51, Issue:1

    Topics: Aminoquinolines; Amodiaquine; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Madaga

1984
Management of Plasmodium falciparum malaria.
    The Medical journal of Australia, 1984, Oct-13, Volume: 141, Issue:8

    Topics: Amodiaquine; Anemia; Antimalarials; Brain Diseases; Chloroquine; Drug Resistance; Female; Humans; Hy

1984
[Drug prevention of malaria].
    Sovetskaia meditsina, 1983, Issue:11

    Topics: Adolescent; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Humans; Infant; Malari

1983
[Amodiaquine-induced agranulocytosis in malaria prevention: demonstration of an amodiaquine-induced cytotoxic antibody against granulocytes].
    Schweizerische medizinische Wochenschrift, 1983, Dec-17, Volume: 113, Issue:50

    Topics: Adolescent; Agglutinins; Agranulocytosis; Amodiaquine; Antibody-Dependent Cell Cytotoxicity; Blood T

1983
Reduction in malaria parasite rate in young children by distribution of prophylactic amodiaquine through voluntary village workers.
    Papua and New Guinea medical journal, 1981, Volume: 24, Issue:4

    Topics: Amodiaquine; Child, Preschool; Humans; Infant; Infant, Newborn; Malaria; Papua New Guinea; Pilot Pro

1981
Chloroquine resistant Plasmodium falciparum malaria in East New Britain, Papua New Guinea.
    Papua and New Guinea medical journal, 1980, Volume: 23, Issue:3

    Topics: Amodiaquine; Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; Malaria; Plasmodium fal

1980
Malaria and growth stunting in young children of the highlands of Papua New Guinea.
    Papua and New Guinea medical journal, 1980, Volume: 23, Issue:3

    Topics: Amodiaquine; Anthropometry; Child; Child, Preschool; Chloroquine; Female; Growth Disorders; Health S

1980
Response to 600 mg amodiaquine base with 45 mg primaquine as presumptive treatment in chloroquine resistant Plasmodium falciparum infection in Assam.
    The Indian journal of medical research, 1980, Volume: 72

    Topics: Adolescent; Adult; Amodiaquine; Child; Chloroquine; Drug Resistance, Microbial; Humans; India; Infan

1980
Synthesis of some novel amodiaquine analogues as potential antimalarial and antifilarial compounds.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:12

    Topics: Amodiaquine; Animals; Anthelmintics; Antimalarials; Chemical Phenomena; Chemistry; Filariasis; Filar

1981
Acute malaria in children in Madang: endemicity, clinical presentation and treatment.
    Papua and New Guinea medical journal, 1981, Volume: 24, Issue:2

    Topics: Amodiaquine; Child, Preschool; Chloroquine; Drug Resistance; Humans; Malaria; Papua New Guinea; Plas

1981
Use and misuse of 4-aminoquinoline antimalarials in tropical Africa and re-examination of itch reaction to these drugs.
    Tropical doctor, 1981, Volume: 11, Issue:3

    Topics: Amodiaquine; Chloroquine; Health Surveys; Humans; Malaria; Nigeria; Pruritus

1981
[Amodiaquine-induced agranulocytosis].
    La Nouvelle presse medicale, 1981, Sep-26, Volume: 10, Issue:34

    Topics: Adult; Agranulocytosis; Amodiaquine; Humans; Malaria; Male

1981
The effect of chemical substitution on the metabolic activation, metabolic detoxication, and pharmacological activity of amodiaquine in the mouse.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 273, Issue:1

    Topics: Amodiaquine; Animals; Bile; Biotransformation; Inactivation, Metabolic; Malaria; Male; Mice; Structu

1995
[Cytokines and malaria. A study of TNF-alpha, IL1-beta, IL6 and IL2R in 28 patients].
    Bulletin de la Societe de pathologie exotique (1990), 1994, Volume: 87, Issue:2

    Topics: Adolescent; Adult; Amodiaquine; C-Reactive Protein; Chloroquine; Humans; Interleukin-1; Interleukin-

1994
Amodiaquine.
    Lancet (London, England), 1996, Dec-14, Volume: 348, Issue:9042

    Topics: Africa South of the Sahara; Amodiaquine; Antimalarials; Chloroquine; Drug Resistance; Health Policy;

1996
"One-pot" synthesis and antimalarial activity of formamidine derivatives of 4-anilinoquinoline.
    Chemical & pharmaceutical bulletin, 2001, Volume: 49, Issue:8

    Topics: Amidines; Amodiaquine; Animals; Antimalarials; Cell Line; Humans; Inhibitory Concentration 50; Macro

2001
Amodiaquine: the exempted antimalarial drug in Ethiopia.
    Ethiopian medical journal, 1998, Volume: 36, Issue:4

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Ethiopia; Humans; Malaria; Plasmo

1998
Amodiaquin accumulation by mouse erythrocytes infected with Plasmodium berghei.
    The Journal of pharmacology and experimental therapeutics, 1975, Volume: 195, Issue:3

    Topics: Amodiaquine; Animals; Erythrocytes; Glucose; Hydrogen-Ion Concentration; Malaria; Male; Mice; Plasmo

1975
Prevention and treatment of malaria.
    Tropical doctor, 1977, Volume: 7, Issue:1

    Topics: Amodiaquine; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum; Pyrimethamine; Qu

1977
Field evaluation of primaquine in the control of Plasmodium vivax.
    The American journal of tropical medicine and hygiene, 1978, Volume: 27, Issue:3

    Topics: Adolescent; Adult; Amodiaquine; Child; Child, Preschool; Humans; Infant; Malaria; Plasmodium vivax;

1978
Activities of various 4-aminoquinolines against infections with chloroquine-resistant strains of Plasmodium falciparum.
    Antimicrobial agents and chemotherapy, 1977, Volume: 11, Issue:5

    Topics: Aminoquinolines; Amodiaquine; Animals; Chloroquine; Drug Resistance, Microbial; Female; Haplorhini;

1977
A pocket of controlled malaria in a holoendemic region of West Africa.
    Annals of tropical medicine and parasitology, 1979, Volume: 73, Issue:4

    Topics: Amodiaquine; Anopheles; Child; Child, Preschool; Chloroquine; Costs and Cost Analysis; Humans; Liber

1979
Chloroquine-resistant falciparum malaria from Irian Jaya (Indonesian New Guinea).
    The Journal of tropical medicine and hygiene, 1976, Volume: 79, Issue:2

    Topics: Amodiaquine; Chloroquine; Drug Resistance; Humans; Malaria; Male; Piperidines; Plasmodium falciparum

1976
Letter: Response of Ethiopian strains of Plasmodium falciparum to amodiaquine.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1975, Volume: 69, Issue:5-6

    Topics: Amodiaquine; Ethiopia; Malaria; Plasmodium falciparum

1975
Evaluating new antimalarial drugs against trophozoite induced Plasmodium cynomolgi malaria in rhesus monkeys.
    The American journal of tropical medicine and hygiene, 1976, Volume: 25, Issue:1

    Topics: Amodiaquine; Animals; Antimalarials; Dapsone; Disease Models, Animal; Dose-Response Relationship, Dr

1976
[Chemotherapy and chemoprophylaxis of malaria (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1976, Aug-27, Volume: 118, Issue:35

    Topics: Adult; Amodiaquine; Antimalarials; Asia, Southeastern; Central America; Child; Chloroquine; Drug Res

1976
Host failure in treatment of malaria with sulfalene and pyrimethamine.
    Annals of internal medicine, 1975, Volume: 82, Issue:2

    Topics: Adult; Amodiaquine; Drug Resistance; Drug Therapy, Combination; Erythrocytes; Humans; Malaria; Male;

1975
The chemotherapy of rodent malaria. XLVII. Studies on pyronaridine and other Mannich base antimalarials.
    Annals of tropical medicine and parasitology, 1992, Volume: 86, Issue:5

    Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Drug Resistance; Malaria; Mannich Bases; Mice;

1992
[The blood schizontocidal effects of pyronaridine, amodiaquine, mefloquine and qinghaosu on mice infected with Plasmodium berghei].
    Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1992, Volume: 10, Issue:2

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Drug Resistance; Female; Malaria; Male; Mefloquin

1992
Comparison of effects of pyronaridine, amodiaquine, mefloquine and qinghaosu on rodent malaria.
    The Southeast Asian journal of tropical medicine and public health, 1992, Volume: 23, Issue:1

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Drug Administration Schedule; Drug Evaluation, Pr

1992
Efficacy of amodiaquine against chloroquine-resistant malaria in Cameroon.
    Lancet (London, England), 1991, Oct-26, Volume: 338, Issue:8774

    Topics: Adolescent; Adult; Amodiaquine; Animals; Cameroon; Child; Child, Preschool; Chloroquine; Drug Resist

1991
Drug use and design in the nineties.
    Acta Leidensia, 1991, Volume: 60, Issue:1

    Topics: Aminoquinolines; Amodiaquine; Antimalarials; Artemisinins; Calcium Channel Blockers; Chloroquine; Hu

1991
[Prevention and treatment of malaria in expatriates living in Black Africa. Influence of chemoresistance. Investigations conducted in Brazzaville (Congo)].
    Presse medicale (Paris, France : 1983), 1991, Jun-22, Volume: 20, Issue:24

    Topics: Adolescent; Adult; Aged; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine;

1991
Stabilization of drug resistance (chloroquine and amodiaquine) of Plasmodium falciparum in semiimmune populations in the Congo.
    The Journal of infectious diseases, 1991, Volume: 164, Issue:2

    Topics: Amodiaquine; Animals; Child; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum

1991
Resistance to antimalarials by Plasmodium falciparum in Arso PIR, Irian Jaya, Indonesia.
    The American journal of tropical medicine and hygiene, 1991, Volume: 44, Issue:6

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Female; Humans

1991
Infection of Aotus vociferans monkeys with different strains of Plasmodium falciparum.
    The Journal of parasitology, 1991, Volume: 77, Issue:4

    Topics: Amodiaquine; Animals; Anopheles; Cebidae; Chloroquine; Malaria; Mefloquine; Plasmodium falciparum; T

1991
Detection of antidrug IgG antibodies in patients with adverse drug reactions to amodiaquine.
    International archives of allergy and applied immunology, 1991, Volume: 95, Issue:4

    Topics: Adult; Aged; Amodiaquine; Antibodies, Anti-Idiotypic; Chloroquine; Dose-Response Relationship, Immun

1991
[Comparative efficacy of chloroquine and amodiaquine (25 and 35 mg/kg) in school children infected with P. falciparum (Brazzaville, March 1990)].
    Bulletin de la Societe de pathologie exotique (1990), 1991, Volume: 84, Issue:1

    Topics: Amodiaquine; Animals; Child; Chloroquine; Congo; Humans; Malaria; Plasmodium falciparum

1991
An in-vitro profile of the action of four antimalarials on indigenous cases of Plasmodium falciparum malaria in Karnataka.
    The Journal of communicable diseases, 1990, Volume: 22, Issue:4

    Topics: Amodiaquine; Animals; Chloroquine; Drug Resistance, Microbial; Malaria; Mefloquine; Microbial Sensit

1990
[Uncomplicated malaria attack in an area with high chloroquine resistance. 2. Evaluation of first-choice therapeutic scheme].
    Bulletin de la Societe de pathologie exotique (1990), 1990, Volume: 83, Issue:1

    Topics: Amodiaquine; Animals; Cameroon; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Human

1990
The in vitro response of Plasmodium falciparum to amodiaquine, quinine and quinidine in Tanga region, Tanzania.
    East African medical journal, 1990, Volume: 67, Issue:5

    Topics: Adolescent; Amodiaquine; Animals; Child; Drug Resistance; Humans; Malaria; Plasmodium falciparum; Qu

1990
[Plasmodium falciparum drug resistance in the Congo. Evaluation of surveys carried out from 1985 to 1989].
    Bulletin de la Societe de pathologie exotique (1990), 1990, Volume: 83, Issue:2

    Topics: Adolescent; Aminoquinolines; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroqui

1990
The disposition of amodiaquine in Zambians and Nigerians with malaria.
    British journal of clinical pharmacology, 1990, Volume: 29, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Amodiaquine; Erythrocytes; Female; Humans; Malaria; Male; M

1990
Low response of Colombian strains of Plasmodium vivax to classical antimalarial therapy.
    Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1989, Volume: 40, Issue:1

    Topics: Adult; Aged; Amodiaquine; Animals; Chloroquine; Colombia; Drug Resistance; Drug Therapy, Combination

1989
[In vivo sensitivity of Plasmodium falciparum to amodiaquine in the town of Edea (Cameroon)].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1989, Volume: 82, Issue:2

    Topics: Amodiaquine; Animals; Child; Conjunctival Diseases; Humans; Hyperemia; Malaria; Microbial Sensitivit

1989
[Surveillance of Plasmodium falciparum drug sensitivity in Yaounde and its surroundings (Cameroon). In vivo and in vitro study].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1989, Volume: 82, Issue:2

    Topics: Adolescent; Adult; Amodiaquine; Animals; Antimalarials; Cameroon; Child; Child, Preschool; Chloroqui

1989
[Malaria in Guiana. I. General status of the endemic].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1989, Volume: 82, Issue:3

    Topics: Adolescent; Adult; Amodiaquine; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Fren

1989
Curative and preventive treatment of uncomplicated malaria in public health institutions in Cameroon.
    European journal of epidemiology, 1989, Volume: 5, Issue:2

    Topics: Amodiaquine; Antimalarials; Cameroon; Child; Chloroquine; Drug Combinations; Female; Humans; Malaria

1989
Fatal acute hepatitis due to amodiaquine.
    Journal of clinical gastroenterology, 1989, Volume: 11, Issue:5

    Topics: Adult; Amodiaquine; Chemical and Drug Induced Liver Injury; Female; Humans; Malaria

1989
Progress and problems in the diagnosis and treatment of malaria and development of an effective referral system in Papua New Guinea.
    Papua and New Guinea medical journal, 1989, Volume: 32, Issue:3

    Topics: Amodiaquine; Chloroquine; Humans; Laboratories; Malaria; Papua New Guinea; Referral and Consultation

1989
Intravenous amodiaquine and oral amodiaquine/erythromycin in the treatment of chloroquine-resistant falciparum malaria.
    Lancet (London, England), 1985, Oct-12, Volume: 2, Issue:8459

    Topics: Administration, Oral; Adolescent; Adult; Amodiaquine; Child; Chloroquine; Drug Combinations; Drug Re

1985
Chloroquine and amodiaquine resistant falciparum malaria in Rwanda.
    Lancet (London, England), 1985, Nov-09, Volume: 2, Issue:8463

    Topics: Amodiaquine; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Rwanda

1985
Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria.
    Lancet (London, England), 1986, Feb-22, Volume: 1, Issue:8478

    Topics: Acute Disease; Adult; Agranulocytosis; Amodiaquine; Drug Combinations; Drug Therapy, Combination; Fe

1986
Neutropenia and prophylactic amodiaquine.
    Lancet (London, England), 1986, Mar-08, Volume: 1, Issue:8480

    Topics: Adolescent; Aged; Agranulocytosis; Amodiaquine; Humans; Malaria; Male; Middle Aged; Neutropenia

1986
Amodiaquine-induced hepatitis. A report of seven cases.
    Annals of internal medicine, 1986, Volume: 104, Issue:6

    Topics: Adult; Alanine Transaminase; Amodiaquine; Aspartate Aminotransferases; Asthenia; Chemical and Drug I

1986
Amodiaquine-resistant malaria in Brazil.
    Lancet (London, England), 1987, Sep-19, Volume: 2, Issue:8560

    Topics: Adolescent; Adult; Amodiaquine; Brazil; Drug Evaluation; Drug Resistance; Female; Humans; Malaria; M

1987
Hypohaptoglobinaemia as an epidemiological and clinical indicator for malaria. Results of two studies in a hyperendemic region in West Africa.
    Lancet (London, England), 1988, Sep-24, Volume: 2, Issue:8613

    Topics: Adolescent; Adult; Africa, Western; Amodiaquine; Animals; Carrier State; Child; Cross-Sectional Stud

1988
Amodiaquine-induced immune agranulocytosis.
    British journal of haematology, 1989, Volume: 71, Issue:1

    Topics: Agranulocytosis; Amodiaquine; Female; Humans; Immunoglobulin G; Malaria; Male; Middle Aged; Neutroph

1989
Serial studies on the evolution of drug resistance in malaria in an area of east Africa: findings from 1979 up to 1986.
    The Journal of tropical medicine and hygiene, 1988, Volume: 91, Issue:5

    Topics: Age Factors; Amodiaquine; Animals; Antibodies, Protozoan; Antimalarials; Child; Child, Preschool; Ch

1988
In vivo and in vitro sensitivity of Plasmodium falciparum to chloroquine at Lubwe and Kalene in Zambia: use of amodiaquine as an alternative antimalarial drug.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1988, Volume: 82, Issue:2

    Topics: Adolescent; Amodiaquine; Animals; Child; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium f

1988
Multiple drug resistant Plasmodium falciparum malaria in a pregnant indigenous Zambian woman.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1988, Volume: 82, Issue:4

    Topics: Adult; Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Erythro

1988
Agranulocytosis associated with the use of amodiaquine for malaria prophylaxis.
    MMWR. Morbidity and mortality weekly report, 1986, Mar-14, Volume: 35, Issue:10

    Topics: Agranulocytosis; Amodiaquine; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; Proguan

1986
Amodiaquine induced agranulocytosis and liver damage.
    British medical journal (Clinical research ed.), 1986, Mar-15, Volume: 292, Issue:6522

    Topics: Adolescent; Adult; Aged; Agranulocytosis; Amodiaquine; Chemical and Drug Induced Liver Injury; Femal

1986
In vitro drug response of Plasmodium falciparum in the Philippines: increased resistance to amodiaquine.
    The Southeast Asian journal of tropical medicine and public health, 1987, Volume: 18, Issue:2

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Mefloquine; Phil

1987
[Drug resistance of Plasmodium falciparum in the Congo. 2. Comparative study in vivo of chloroquine and amodiaquine in Brazzaville schoolchildren (November 1986)].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1987, Volume: 80, Issue:3 Pt 2

    Topics: Amodiaquine; Animals; Child; Chloroquine; Congo; Drug Resistance; Female; Humans; Malaria; Male; Pla

1987
[Status of drug resistance of Plasmodium falciparum in the Central African Republic. Results of studies carried out between 1984 and 1986].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1987, Volume: 80, Issue:3 Pt 2

    Topics: Amodiaquine; Animals; Antimalarials; Central African Republic; Child; Child, Preschool; Chloroquine;

1987
[Drug sensitivity of malaria in a population of children in Pointe-Noire, Congo, in the first half of 1986].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1987, Volume: 80, Issue:3 Pt 2

    Topics: Adolescent; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Congo; Drug R

1987
[2 cases of multiresistant Plasmodium falciparum malaria contracted in Douala with atypical clinical presentation].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1987, Volume: 80, Issue:3 Pt 2

    Topics: Adolescent; Adult; Amodiaquine; Animals; Antimalarials; Cameroon; Chloroquine; Drug Combinations; Dr

1987
[Sensitivity of Plasmodium falciparum to quinolines and therapeutic strategies: comparison of the situation in Africa and Madagascar between 1983 and 1986].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1987, Volume: 80, Issue:3 Pt 2

    Topics: Amodiaquine; Angola; Animals; Antimalarials; Burkina Faso; Cameroon; Chloroquine; Drug Resistance; H

1987
[Development of drug resistance in cases of P. falciparum malaria of African origin in a Parisian hospital. Comparison with field data and therapeutic consequences].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1987, Volume: 80, Issue:3 Pt 2

    Topics: Africa; Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; France

1987
[Current aspects of imported drug-resistant Plasmodium falciparum].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1987, Volume: 80, Issue:3 Pt 2

    Topics: Adult; Africa, Central; Aged; Aged, 80 and over; Amodiaquine; Animals; Antimalarials; Chloroquine; D

1987
Disposition of monodesethylamodiaquine after a single oral dose of amodiaquine and three regimens for prophylaxis against Plasmodium falciparum malaria.
    European journal of clinical pharmacology, 1987, Volume: 33, Issue:4

    Topics: Adult; Amiodarone; Amodiaquine; Animals; Female; Half-Life; Humans; Malaria; Male; Middle Aged; Plas

1987
Amodiaquine fails to cure chloroquine resistant Plasmodium falciparum in the Punjab.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987, Volume: 81, Issue:1

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Mefloquine; Paki

1987
Comparative efficacy of alternative primary therapies for Plasmodium falciparum infections in Malawi.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987, Volume: 81, Issue:5

    Topics: Amodiaquine; Animals; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Humans; Mal

1987
[Synthesis of trifluoromethyl amodiaquine analogs and antimalarial activity].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1987, Volume: 22, Issue:6

    Topics: Amodiaquine; Animals; Antimalarials; Chemical Phenomena; Chemistry; Malaria; Mice; Plasmodium berghe

1987
[In vivo and in vitro sensitivity to 4-aminoquinolines of Plasmodium falciparum in Madagascar: results of a study conducted on the east coast (July 1985-July 1986)].
    Archives de l'Institut Pasteur de Madagascar, 1987, Volume: 53, Issue:1

    Topics: Adolescent; Adult; Aminoquinolines; Amodiaquine; Animals; Child; Child, Preschool; Chloroquine; Drug

1987
[In vivo and in vitro study of the chemosensitivity of Plasmodium falciparum in Madagascar--1982-1986].
    Archives de l'Institut Pasteur de Madagascar, 1987, Volume: 53, Issue:1

    Topics: Adolescent; Amodiaquine; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Inf

1987
Amodiaquine-induced fulminant hepatitis.
    Journal of hepatology, 1988, Volume: 6, Issue:1

    Topics: Adolescent; Adult; Amodiaquine; Chemical and Drug Induced Liver Injury; Female; Humans; Malaria; Mal

1988
Clinical pharmacology looks at tropical medicine.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987, Volume: 81, Issue:4

    Topics: Amodiaquine; Anthelmintics; Antimalarials; Chloroquine; Diethylcarbamazine; Filariasis; Filaricides;

1987
Amodiaquine in malaria treatment.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987, Volume: 81, Issue:6

    Topics: Amodiaquine; Humans; Malaria

1987
[A fatal case of chloroquine-resistant neuromalaria in a traveller to Cameroon].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1986, Volume: 79, Issue:1

    Topics: Africa; Amodiaquine; Cameroon; Cerebral Hemorrhage; Chloroquine; Coma; Drug Resistance; Humans; Mala

1986
[Drug sensitivity of malaria in Madagascar. Comparison in vivo and in vitro of the effects of chloroquine and amodiaquine on P. falciparum in 1984].
    Archives de l'Institut Pasteur de Madagascar, 1986, Volume: 52, Issue:1

    Topics: Adolescent; Amodiaquine; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Madagascar;

1986
Neuromyopathy associated with amodiaquine hydrochloride.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1987, Oct-01, Volume: 137, Issue:7

    Topics: Adult; Amodiaquine; Female; Humans; Malaria; Neuromuscular Diseases

1987
Neutropenia associated with dual antimalarial chemoprophylaxis--use of bone-marrow culture as an aid in further drug management.
    The Journal of infection, 1987, Volume: 15, Issue:2

    Topics: Adult; Agranulocytosis; Amodiaquine; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Drug Therapy,

1987
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis.
    The Journal of tropical medicine and hygiene, 1987, Volume: 90, Issue:5

    Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Erythrocyte Cou

1987
Complications of antimalarial prophylaxis.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1986, Aug-16, Volume: 70, Issue:4

    Topics: Amodiaquine; Antimalarials; Drug Therapy, Combination; Humans; Malaria

1986
Amodiaquine and hepatitis.
    Annals of internal medicine, 1986, Volume: 105, Issue:3

    Topics: Adult; Amodiaquine; Drug Resistance; Female; Humans; Malaria; Male

1986
[Amodiaquine-induced hepatitis with leukopenia].
    Schweizerische medizinische Wochenschrift, 1986, Jul-19, Volume: 116, Issue:29

    Topics: Adult; Agranulocytosis; Amodiaquine; Chemical and Drug Induced Liver Injury; Diagnosis, Differential

1986
Lack of effect of antimalarial prophylaxis with chloroquine or amodiaquine in cutaneous leishmaniasis in French Guiana.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1986, Volume: 80, Issue:3

    Topics: Amodiaquine; Chloroquine; Humans; Leishmaniasis; Malaria

1986
Pharmacokinetics of intravenous amodiaquine.
    British journal of clinical pharmacology, 1987, Volume: 23, Issue:2

    Topics: Adult; Amodiaquine; Humans; Infusions, Intravenous; Injections, Intravenous; Kinetics; Malaria; Male

1987
The role of voluntary village aides in the control of malaria by presumptive treatment of fever. 1. Selection, training and practice.
    Papua and New Guinea medical journal, 1985, Volume: 28, Issue:4

    Topics: Adult; Amodiaquine; Attitude to Health; Chloroquine; Community Health Workers; Female; Fever; Humans

1985
The role of voluntary village aides in the control of malaria by presumptive treatment of fever. 2. Impact on village health.
    Papua and New Guinea medical journal, 1985, Volume: 28, Issue:4

    Topics: Adolescent; Amodiaquine; Child; Child, Preschool; Chloroquine; Community Health Workers; Fever; Huma

1985
Studies of resistance to chloroquine, quinine, amodiaquine and mefloquine among Philippine strains of Plasmodium falciparum.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1985, Volume: 79, Issue:1

    Topics: Amodiaquine; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Mefloquine; Ph

1985
Sensitivity of Plasmodium falciparum to antimalarial drugs in Colombia.
    The American journal of tropical medicine and hygiene, 1985, Volume: 34, Issue:4

    Topics: Amodiaquine; Antimalarials; Chloroquine; Colombia; Drug Combinations; Drug Resistance, Microbial; Ge

1985
Malaria prophylaxis for Canadian travellers.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1985, Nov-15, Volume: 133, Issue:10

    Topics: Amodiaquine; Canada; Chloroquine; Dapsone; Doxycycline; Drug Combinations; Drug Resistance, Microbia

1985
Plasmodium falciparum in Madagascar: in vivo and in vitro sensitivity to seven drugs.
    Annals of tropical medicine and parasitology, 1985, Volume: 79, Issue:4

    Topics: Adolescent; Adult; Aged; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Humans; I

1985
Malaria, cause of ahaptoglobinaemia in Africans.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1985, Volume: 79, Issue:4

    Topics: Amodiaquine; Antimalarials; Child; Congo; Haptoglobins; Humans; Malaria; Mefloquine; Plasmodium falc

1985
[In vivo and in vitro sensitivity to 4-aminoquinolines of Plasmodium falciparum in Madagascar: results of 2 years' study].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1985, Volume: 78, Issue:5

    Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; Human

1985
Drug-resistant malaria--changing patterns mean difficult decisions.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1985, Volume: 79, Issue:6

    Topics: Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Humans

1985
[Pharmacokinetics of amodiaquine and prevention of Plasmodium falciparum malaria].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1985, Volume: 78, Issue:5 Pt 2

    Topics: Adult; Amodiaquine; Female; Half-Life; Humans; Malaria; Male; Middle Aged; Plasmodium falciparum

1985
[Biotransformation of amiodaquine and prophylaxis of Plasmodium falciparum malaria].
    Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 1985, Volume: 301, Issue:8

    Topics: Amodiaquine; Animals; Biotransformation; Chromatography, High Pressure Liquid; Erythrocytes; Female;

1985
High-performance liquid chromatographic analysis of amodiaquine in human plasma.
    Journal of chromatography, 1985, Jan-11, Volume: 337, Issue:1

    Topics: Adult; Amodiaquine; Chromatography, High Pressure Liquid; Drug Stability; Half-Life; Humans; Malaria

1985
Amodiaquine-induced agranulocytosis: drug inhibition of myeloid colonies in the presence of patient's serum.
    Israel journal of medical sciences, 1985, Volume: 21, Issue:4

    Topics: Agranulocytosis; Amodiaquine; Bone Marrow Cells; Colony-Forming Units Assay; Dipyrone; Drug Interact

1985
Response to treatment in man of multi-drug resistant Plasmodium falciparum from Panama.
    The American journal of tropical medicine and hygiene, 1974, Volume: 23, Issue:1

    Topics: Adult; Amodiaquine; Animals; Anopheles; Antimalarials; Chloroquine; Drug Resistance, Microbial; Drug

1974
Characterization of a drug resistant strain of Plasmodium falciparum from Burma.
    The Journal of tropical medicine and hygiene, 1973, Volume: 76, Issue:3

    Topics: Adult; Amodiaquine; Anopheles; Chloroquine; Drug Resistance, Microbial; Human Experimentation; Human

1973
Mass drug administration as a supplementary attack measure in malaria eradication programme.
    East African medical journal, 1974, Volume: 51, Issue:7

    Topics: Adolescent; Amodiaquine; Child; Child, Preschool; Chloroquine; Drug Combinations; Humans; Indian Oce

1974
A method for the determination of amodiaquine.
    Bulletin of the World Health Organization, 1974, Volume: 51, Issue:4

    Topics: Amodiaquine; Humans; Malaria; Spectrometry, Fluorescence

1974
Plasmodium falciparum malaria in Panama resistant to 4-aminoquinoline drugs.
    The American journal of tropical medicine and hygiene, 1972, Volume: 21, Issue:2

    Topics: Amodiaquine; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Panama; Plasmodium falciparum

1972
Preliminary studies on a Philippine strain of Plasmodium falciparum resistant to amodiaquine.
    The Journal of tropical medicine and hygiene, 1972, Volume: 75, Issue:7

    Topics: Adult; Amodiaquine; Body Weight; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Phi

1972
Response of drug-resistant Plasmodium falciparum to combined therapy in Panama.
    The Journal of tropical medicine and hygiene, 1972, Volume: 75, Issue:7

    Topics: Adult; Amodiaquine; Child; Chloroquine; Drug Resistance, Microbial; Humans; Infant; Malaria; Panama;

1972
[Treatment of malaria].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1972, Nov-10, Volume: 92, Issue:31

    Topics: Adolescent; Amodiaquine; Child; Child, Preschool; Humans; Infant; Malaria; Plasmodium; Plasmodium fa

1972
Characterisation of a drug resistant strain of Plasmodium falciparum from Sabah.
    The Journal of tropical medicine and hygiene, 1973, Volume: 76, Issue:9

    Topics: Adult; Amodiaquine; Borneo; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Plasmodi

1973
Malaria in New York City. IV. 1960-1971.
    The Journal of tropical medicine and hygiene, 1974, Volume: 77, Issue:1

    Topics: Adolescent; Adult; Africa, Western; Age Factors; Amodiaquine; Child; Child, Preschool; Chloroquine;

1974
The chemotherapy and prophylaxis of malaria.
    The Medical journal of Australia, 1973, Dec-08, Volume: 2, Issue:23

    Topics: Adolescent; Adult; Amodiaquine; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Fe

1973
Considerations on the use of sulphones and sulphonamides with a pyrimidine derivative.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1974, Jun-09, Volume: 48, Issue:31

    Topics: Adult; Amodiaquine; Child; Dapsone; Drug Combinations; Drug Resistance, Microbial; Humans; Malaria;

1974
Amodiaquine analogs. Synthesis of 6-((3-(N,N-diethylamino)methyl-4-hydroxy)anilino)5,8-dimethoxy-2,4-dimethylquinoline and related compounds.
    Journal of medicinal chemistry, 1974, Volume: 17, Issue:9

    Topics: Amodiaquine; Aniline Compounds; Animals; Antimalarials; Diethylamines; Macaca; Malaria; Mice; Plasmo

1974
[Treatment of drug-resistant malaria: animal experiments].
    Bulletin of the World Health Organization, 1974, Volume: 50, Issue:3-4

    Topics: Amodiaquine; Animals; Chloroquine; Drug Evaluation, Preclinical; Drug Resistance; Drug Therapy, Comb

1974
[Increased incidence of malaria in Sinai and its prevention].
    Harefuah, 1973, Feb-15, Volume: 84, Issue:4

    Topics: Adult; Amodiaquine; Humans; Israel; Malaria; Male; Time Factors

1973
Determination of the drug sensitivity of Plasmodium falciparum.
    JAMA, 1971, Aug-02, Volume: 217, Issue:5

    Topics: Acute Disease; Amodiaquine; Antimalarials; Chloroquine; Drug Resistance, Microbial; Folic Acid Antag

1971
The routine treatment of malaria.
    Tropical doctor, 1971, Volume: 1, Issue:4

    Topics: Acute Disease; Adolescent; Adult; Amodiaquine; Child; Child, Preschool; Chloroquine; Chronic Disease

1971
Preparation of a camoquine derivative with quaternary carbon side chain.
    Journal of medicinal chemistry, 1972, Volume: 15, Issue:3

    Topics: Amodiaquine; Animals; Antimalarials; Malaria; Mice

1972
The role of drugs in a malaria program.
    The American journal of tropical medicine and hygiene, 1972, Volume: 21, Issue:5

    Topics: Amodiaquine; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Humans; Malaria; Primaqui

1972
Is malaria chemosuppression necessary in an infant?
    JAMA, 1970, Sep-14, Volume: 213, Issue:11

    Topics: Age Factors; Amodiaquine; Chloroquine; Disease Reservoirs; Humans; Infant, Newborn; Infant, Newborn,

1970
Nonspecific phagocytic activity in rats infected with Plasmodium berghei and treated with amodiaquine or chloroquine.
    The American journal of tropical medicine and hygiene, 1970, Volume: 19, Issue:6

    Topics: Amodiaquine; Animals; Body Weight; Carbon; Chloroquine; Colloids; Injections, Intravenous; Liver; Lu

1970
Plasmodium berghei: phagocytic hyperactivity of infected rats.
    Experimental parasitology, 1970, Volume: 28, Issue:2

    Topics: Amodiaquine; Animals; Carbon; Colloids; Disease Models, Animal; Malaria; Male; Organ Size; Phagocyto

1970
A medicated salt project in the Kazeroun area, Iran--1962-1967.
    The Journal of tropical medicine and hygiene, 1971, Volume: 74, Issue:2

    Topics: Amodiaquine; Anopheles; Blood; Child; Child, Preschool; Chloroquine; Humans; Infant; Infant, Newborn

1971
[Management of acute malaria].
    Deutsche medizinische Wochenschrift (1946), 1968, Aug-16, Volume: 93, Issue:33

    Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Injections, Intramuscular; Malaria; Primaquine; Tro

1968
Characteristics and cross-resistance patterns of chloroquine-resistant Plasmodium berghei infections in mice.
    Experimental parasitology, 1968, Volume: 23, Issue:1

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Dapsone; Drug Resistance, Microbial; Female; Hemat

1968
Repository drugs. 8. Ester and amide congeners of amodiaquine, hydroxychloroquine, oxychloroquine, primaquine, quinacrine, and related substances as potential long-acting antimalarial agents.
    Journal of medicinal chemistry, 1969, Volume: 12, Issue:4

    Topics: Amodiaquine; Animals; Antimalarials; Chemical Phenomena; Chemistry; Delayed-Action Preparations; Est

1969
Drug resistance in Plasmodium berghei Vincke and Lips, 1948. I. Chloroquine resistance.
    Experimental parasitology, 1965, Volume: 17, Issue:1

    Topics: Amodiaquine; Animals; Chloroquine; Dapsone; Malaria; Mice; Plasmodium; Primaquine; Proguanil; Pyrime

1965