amodiaquine has been researched along with Complications, Parasitic Pregnancy in 14 studies
Amodiaquine: A 4-aminoquinoline compound with anti-inflammatory properties.
amodiaquine : A quinoline having a chloro group at the 7-position and an aryl amino group at the 4-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the artesunate-amodiaquine and artemether-lumefantrine combinations in the treatment of acute uncomplicated falciparum malaria during pregnancy." | 9.20 | A randomized trial of artesunate-amodiaquine versus artemether-lumefantrine for the treatment of acute uncomplicated malaria in pregnancy. ( Aboderin, O; Badejoko, O; Fatusi, A; Loto, O; Ogunniyi, S; Ukah, M, 2015) |
| "Pregnant women with non-severe, slide proven, falciparum malaria were randomised to one of 4 regimes: sulfadoxine-pyrimethamine [SP]; chlorproguanil-dapsone [CD]; SP+amodiaquine [SP+AQ] or amodiaquine+artesunate [AQ+AS]." | 9.14 | Randomized trial of artesunate+amodiaquine, sulfadoxine-pyrimethamine+amodiaquine, chlorproguanal-dapsone and SP for malaria in pregnancy in Tanzania. ( Briceño, M; Drakeley, C; Greenwood, BM; Mutabingwa, TK; Muze, K; Ord, R; Whitty, CJ, 2009) |
| "Amodiaquine alone or in combination with sulphadoxine-pyrimethamine, although associated with minor side-effects, is effective when used to treat malaria in pregnancy." | 9.12 | Efficacy, safety, and tolerability of amodiaquine plus sulphadoxine-pyrimethamine used alone or in combination for malaria treatment in pregnancy: a randomised trial. ( Browne, E; Bruce, J; Chandramohan, D; Greenwood, B; Randal, A; Tagbor, H, 2006) |
| "We did a systematic review of interventional or observational cohort studies assessing the efficacy of artemisinin-based or quinine-based treatments in pregnancy." | 9.05 | Efficacy and tolerability of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a systematic review and individual patient data meta-analysis. ( Anvikar, AR; Ashley, EA; Chandramohan, D; Cohee, LM; D'Alessandro, U; Genton, B; Gilder, ME; Guérin, PJ; Juma, E; Kalilani-Phiri, L; Kennon, K; Kuepfer, I; Laufer, MK; Lwin, KM; Mansoor, R; McGready, R; Meshnick, SR; Mosha, D; Mwapasa, V; Mwebaza, N; Nambozi, M; Ndiaye, JA; Nosten, F; Nyunt, M; Ogutu, B; Parikh, S; Paw, MK; Phyo, AP; Pimanpanarak, M; Piola, P; Rijken, MJ; Saito, M; Sriprawat, K; Stepniewska, K; Tagbor, HK; Tarning, J; Tinto, H; Valéa, I; Valecha, N; White, NJ; Wiladphaingern, J, 2020) |
| "Several African countries have begun using amodiaquine-containing combinations as first-line antimalarial treatment, with the result that a substantial number of pregnant women are likely to be exposed to amodiaquine." | 8.82 | Can amodiaquine be used safely during pregnancy? ( D'Alessandro, U; Erhart, A; Thomas, F, 2004) |
| "Amodiaquine is effective for the treatment of Plasmodium vivax malaria, but there is little information on the pharmacokinetic and pharmacodynamic properties of amodiaquine in pregnant women with malaria." | 7.78 | Population pharmacokinetic and pharmacodynamic modeling of amodiaquine and desethylamodiaquine in women with Plasmodium vivax malaria during and after pregnancy. ( Bergstrand, M; Cammas, M; Chotsiri, P; Day, NP; Jullien, V; Lindegardh, N; McGready, R; Nosten, F; Rijken, MJ; Singhasivanon, P; Tarning, J; White, NJ, 2012) |
| " Pregnant women diagnosed with malaria are randomised to receive either amodiaquine-artesunate (AQ-AS), dihydroartemisinin-piperaquine (DHA-PQ), artemether-lumefantrine (AL), or mefloquine-artesunate (MQAS)." | 5.20 | Safe and efficacious artemisinin-based combination treatments for African pregnant women with malaria: a multicentre randomized control trial. ( Claeys, Y; D'Alessandro, U; De Crop, M; Halidou, T; Kalanda, G; Menten, J; Mulenga, M; Mutabingwa, T; Mwakazanga, D; Mwapasa, V; Nambozi, M; Phiri, LK; Ravinetto, R; Schurmans, C; Tagbor, H; Thriemer, K; Traore, M; Valea, I; Van Geertruyden, JP, 2015) |
| "To compare the artesunate-amodiaquine and artemether-lumefantrine combinations in the treatment of acute uncomplicated falciparum malaria during pregnancy." | 5.20 | A randomized trial of artesunate-amodiaquine versus artemether-lumefantrine for the treatment of acute uncomplicated malaria in pregnancy. ( Aboderin, O; Badejoko, O; Fatusi, A; Loto, O; Ogunniyi, S; Ukah, M, 2015) |
| "Pregnant women with non-severe, slide proven, falciparum malaria were randomised to one of 4 regimes: sulfadoxine-pyrimethamine [SP]; chlorproguanil-dapsone [CD]; SP+amodiaquine [SP+AQ] or amodiaquine+artesunate [AQ+AS]." | 5.14 | Randomized trial of artesunate+amodiaquine, sulfadoxine-pyrimethamine+amodiaquine, chlorproguanal-dapsone and SP for malaria in pregnancy in Tanzania. ( Briceño, M; Drakeley, C; Greenwood, BM; Mutabingwa, TK; Muze, K; Ord, R; Whitty, CJ, 2009) |
| "The use of sulfadoxine-pyrimethamine (SP) for intermittent preventive treatment in pregnancy (IPTp) is threatened by the spread of resistance to SP." | 5.13 | A randomized, controlled trial of intermittent preventive treatment with sulfadoxine-pyrimethamine, amodiaquine, or the combination in pregnant women in Ghana. ( Affipunguh, PK; Bruce, J; Chandramohan, D; Clerk, CA; Greenwood, B; Hodgson, A; Mensah, N, 2008) |
| "Amodiaquine alone or in combination with sulphadoxine-pyrimethamine, although associated with minor side-effects, is effective when used to treat malaria in pregnancy." | 5.12 | Efficacy, safety, and tolerability of amodiaquine plus sulphadoxine-pyrimethamine used alone or in combination for malaria treatment in pregnancy: a randomised trial. ( Browne, E; Bruce, J; Chandramohan, D; Greenwood, B; Randal, A; Tagbor, H, 2006) |
| "In October 1988, a project was implemented for assessing the malaria chemoprophylactic efficacy of weekly chloroquine (CQ) and daily proguanil (PROG) during pregnancy in Muheza-Tanzania." | 5.07 | Malaria in infants whose mothers received chemoprophylaxis: response to amodiaquine therapy. ( de Geus, A; Malle, LN; Mutabingwa, TK; Wernsdorfer, WH, 1992) |
| "We did a systematic review of interventional or observational cohort studies assessing the efficacy of artemisinin-based or quinine-based treatments in pregnancy." | 5.05 | Efficacy and tolerability of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a systematic review and individual patient data meta-analysis. ( Anvikar, AR; Ashley, EA; Chandramohan, D; Cohee, LM; D'Alessandro, U; Genton, B; Gilder, ME; Guérin, PJ; Juma, E; Kalilani-Phiri, L; Kennon, K; Kuepfer, I; Laufer, MK; Lwin, KM; Mansoor, R; McGready, R; Meshnick, SR; Mosha, D; Mwapasa, V; Mwebaza, N; Nambozi, M; Ndiaye, JA; Nosten, F; Nyunt, M; Ogutu, B; Parikh, S; Paw, MK; Phyo, AP; Pimanpanarak, M; Piola, P; Rijken, MJ; Saito, M; Sriprawat, K; Stepniewska, K; Tagbor, HK; Tarning, J; Tinto, H; Valéa, I; Valecha, N; White, NJ; Wiladphaingern, J, 2020) |
| "Several African countries have begun using amodiaquine-containing combinations as first-line antimalarial treatment, with the result that a substantial number of pregnant women are likely to be exposed to amodiaquine." | 4.82 | Can amodiaquine be used safely during pregnancy? ( D'Alessandro, U; Erhart, A; Thomas, F, 2004) |
| "Amodiaquine is effective for the treatment of Plasmodium vivax malaria, but there is little information on the pharmacokinetic and pharmacodynamic properties of amodiaquine in pregnant women with malaria." | 3.78 | Population pharmacokinetic and pharmacodynamic modeling of amodiaquine and desethylamodiaquine in women with Plasmodium vivax malaria during and after pregnancy. ( Bergstrand, M; Cammas, M; Chotsiri, P; Day, NP; Jullien, V; Lindegardh, N; McGready, R; Nosten, F; Rijken, MJ; Singhasivanon, P; Tarning, J; White, NJ, 2012) |
| " Additionally, these models are able to identify patient characteristics that cause alterations in the expected PK/PD profiles and through simulations can recommend changes to dosing which compensate for the differences." | 2.72 | Malaria PK/PD and the Role Pharmacometrics Can Play in the Global Health Arena: Malaria Treatment Regimens for Vulnerable Populations. ( Hughes, E; Jagannathan, P; Mohamed Ali, A; Savic, RM; Wallender, E, 2021) |
| " However, increasing Plasmodium falciparum resistance to chloroquine and sulfadoxine-pyrimethamine makes finding alternative antimalarials that are safe and effective in pregnancy a priority." | 2.44 | The safety of amodiaquine use in pregnant women. ( Chandramohan, D; Greenwood, B; Tagbor, HK, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 7 (50.00) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Saito, M | 1 |
| Mansoor, R | 1 |
| Kennon, K | 1 |
| Anvikar, AR | 1 |
| Ashley, EA | 1 |
| Chandramohan, D | 4 |
| Cohee, LM | 1 |
| D'Alessandro, U | 5 |
| Genton, B | 1 |
| Gilder, ME | 1 |
| Juma, E | 1 |
| Kalilani-Phiri, L | 2 |
| Kuepfer, I | 1 |
| Laufer, MK | 1 |
| Lwin, KM | 1 |
| Meshnick, SR | 1 |
| Mosha, D | 1 |
| Mwapasa, V | 3 |
| Mwebaza, N | 1 |
| Nambozi, M | 3 |
| Ndiaye, JA | 1 |
| Nosten, F | 2 |
| Nyunt, M | 1 |
| Ogutu, B | 1 |
| Parikh, S | 1 |
| Paw, MK | 1 |
| Phyo, AP | 1 |
| Pimanpanarak, M | 1 |
| Piola, P | 1 |
| Rijken, MJ | 2 |
| Sriprawat, K | 1 |
| Tagbor, HK | 2 |
| Tarning, J | 2 |
| Tinto, H | 2 |
| Valéa, I | 3 |
| Valecha, N | 1 |
| White, NJ | 2 |
| Wiladphaingern, J | 1 |
| Stepniewska, K | 1 |
| McGready, R | 2 |
| Guérin, PJ | 1 |
| Hughes, E | 1 |
| Wallender, E | 1 |
| Mohamed Ali, A | 1 |
| Jagannathan, P | 1 |
| Savic, RM | 1 |
| Mulenga, M | 2 |
| Halidou, T | 1 |
| Tagbor, H | 3 |
| Phiri, LK | 1 |
| Kalanda, G | 2 |
| Traore, M | 1 |
| Mwakazanga, D | 1 |
| Claeys, Y | 2 |
| Schurmans, C | 2 |
| De Crop, M | 2 |
| Menten, J | 2 |
| Ravinetto, R | 2 |
| Thriemer, K | 2 |
| Van Geertruyden, JP | 2 |
| Mutabingwa, T | 2 |
| Ukah, M | 1 |
| Badejoko, O | 1 |
| Ogunniyi, S | 1 |
| Loto, O | 1 |
| Aboderin, O | 1 |
| Fatusi, A | 1 |
| Pekyi, D | 1 |
| Ampromfi, AA | 1 |
| Traoré-Coulibaly, M | 1 |
| Tahita, MC | 1 |
| Madanitsa, M | 1 |
| Gbekor, P | 1 |
| Antwi, G | 1 |
| Van Overmeir, C | 1 |
| Hachizovu, S | 1 |
| Kabuya, JB | 1 |
| Mulenga, J | 1 |
| Clerk, CA | 1 |
| Bruce, J | 2 |
| Affipunguh, PK | 1 |
| Mensah, N | 1 |
| Hodgson, A | 1 |
| Greenwood, B | 3 |
| Mutabingwa, TK | 2 |
| Muze, K | 1 |
| Ord, R | 1 |
| Briceño, M | 1 |
| Greenwood, BM | 1 |
| Drakeley, C | 1 |
| Whitty, CJ | 1 |
| Chotsiri, P | 1 |
| Jullien, V | 1 |
| Bergstrand, M | 1 |
| Cammas, M | 1 |
| Singhasivanon, P | 1 |
| Day, NP | 1 |
| Lindegardh, N | 1 |
| Thomas, F | 1 |
| Erhart, A | 1 |
| Bhattarai, A | 1 |
| Maini-Thapar, M | 1 |
| Ali, AS | 1 |
| Björkman, A | 1 |
| ter Kuile, FO | 1 |
| Browne, E | 1 |
| Randal, A | 1 |
| Malle, LN | 1 |
| de Geus, A | 1 |
| Wernsdorfer, WH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Safe and Efficacious Artemisinin-based Combination Treatments for African Pregnant Women With Malaria[NCT00852423] | Phase 3 | 3,428 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| Improving Neonatal Health Through Rapid Malaria Testing in Early Pregnancy With High-Sensitivity[NCT05757167] | Phase 4 | 2,500 participants (Anticipated) | Interventional | 2023-11-06 | Recruiting | ||
| Efficacy of Sulphadoxine-pyrimethamine and Amodiaquine Alone or in Combination as Intermittent Preventive Treatment in Pregnancy in the Kassena-Nankana District of Ghana: a Randomized Controlled Trial[NCT00146783] | Phase 2/Phase 3 | 3,642 participants (Actual) | Interventional | 2004-06-30 | Completed | ||
| Treating Malaria During Pregnancy: A Randomized Trial of Potential Options for Treatment in an Area of High Drug Resistance in Tanzania[NCT00146731] | Phase 3 | 310 participants (Actual) | Interventional | 2004-01-31 | Completed | ||
| A Randomised Double Blind Clinical Trial of Amodiaquine (AQ) and Sulphadoxine-pyrimethamine (SP) Used Singly and in Combination (AQ+SP) Compared With Chloroquine (CQ) in the Treatment of Falciparum Malaria Infection in Pregnancy[NCT00131703] | Phase 3 | 900 participants | Interventional | 2003-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for amodiaquine and Complications, Parasitic Pregnancy
| Article | Year |
|---|---|
Efficacy and tolerability of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a systematic review and individual patient data meta-analysis.
Topics: Amodiaquine; Anti-Bacterial Agents; Antimalarials; Artemisinins; Artesunate; Atovaquone; Clindamycin | 2020 |
Malaria PK/PD and the Role Pharmacometrics Can Play in the Global Health Arena: Malaria Treatment Regimens for Vulnerable Populations.
Topics: Amodiaquine; Anti-HIV Agents; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins | 2021 |
Can amodiaquine be used safely during pregnancy?
Topics: Africa; Amodiaquine; Antimalarials; Contraindications; Female; Humans; Malaria; Pregnancy; Pregnancy | 2004 |
The safety of amodiaquine use in pregnant women.
Topics: Amodiaquine; Animals; Antimalarials; Female; Humans; Malaria, Falciparum; Pregnancy; Pregnancy Compl | 2007 |
7 trials available for amodiaquine and Complications, Parasitic Pregnancy
| Article | Year |
|---|---|
Safe and efficacious artemisinin-based combination treatments for African pregnant women with malaria: a multicentre randomized control trial.
Topics: Adult; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesuna | 2015 |
A randomized trial of artesunate-amodiaquine versus artemether-lumefantrine for the treatment of acute uncomplicated malaria in pregnancy.
Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisini | 2015 |
Four Artemisinin-Based Treatments in African Pregnant Women with Malaria.
Topics: Adult; Africa; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; | 2016 |
Four Artemisinin-Based Treatments in African Pregnant Women with Malaria.
Topics: Adult; Africa; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; | 2016 |
Four Artemisinin-Based Treatments in African Pregnant Women with Malaria.
Topics: Adult; Africa; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; | 2016 |
Four Artemisinin-Based Treatments in African Pregnant Women with Malaria.
Topics: Adult; Africa; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; | 2016 |
A randomized, controlled trial of intermittent preventive treatment with sulfadoxine-pyrimethamine, amodiaquine, or the combination in pregnant women in Ghana.
Topics: Amodiaquine; Anemia; Animals; Antimalarials; Child, Preschool; Drug Combinations; Drug Therapy, Comb | 2008 |
Randomized trial of artesunate+amodiaquine, sulfadoxine-pyrimethamine+amodiaquine, chlorproguanal-dapsone and SP for malaria in pregnancy in Tanzania.
Topics: Adult; Amodiaquine; Artemisinins; Artesunate; Dapsone; Drug Combinations; Drug Therapy, Combination; | 2009 |
Efficacy, safety, and tolerability of amodiaquine plus sulphadoxine-pyrimethamine used alone or in combination for malaria treatment in pregnancy: a randomised trial.
Topics: Adult; Amodiaquine; Antimalarials; Chloroquine; Drug Administration Schedule; Drug Combinations; Fem | 2006 |
Malaria in infants whose mothers received chemoprophylaxis: response to amodiaquine therapy.
Topics: Administration, Oral; Amodiaquine; Chloroquine; Drug Resistance; Female; Humans; Immunity, Maternall | 1992 |
3 other studies available for amodiaquine and Complications, Parasitic Pregnancy
| Article | Year |
|---|---|
Population pharmacokinetic and pharmacodynamic modeling of amodiaquine and desethylamodiaquine in women with Plasmodium vivax malaria during and after pregnancy.
Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Biotransformation; Body Weight; Drug Administration S | 2012 |
Amodiaquine during pregnancy.
Topics: Adult; Amodiaquine; Antimalarials; Artemisinins; Drug Therapy, Combination; Female; Humans; Malaria; | 2004 |
Amodiaquine, malaria, pregnancy: the old new drug.
Topics: Amodiaquine; Antimalarials; Drug Combinations; Drug Therapy, Combination; Female; Ghana; Humans; Mal | 2006 |