amodiaquine has been researched along with Chemical and Drug Induced Liver Injury in 28 studies
Amodiaquine: A 4-aminoquinoline compound with anti-inflammatory properties.
amodiaquine : A quinoline having a chloro group at the 7-position and an aryl amino group at the 4-position.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seven cases of agranulocytosis and two of liver damage that were probably due to amodiaquine treatment were studied." | 7.67 | Amodiaquine induced agranulocytosis and liver damage. ( Fehr, J; Frick, PG; Neftel, KA; Schmid, M; Woodtly, W, 1986) |
| "Two patients are presented who during malaria prophylaxis with amodiaquine developed a hepatitis associated with granulocytopenia of short duration." | 7.67 | [Amodiaquine-induced hepatitis with leukopenia]. ( Siegrist, P; Vonmoos, P; Woodtli, W; Zollikofer, H, 1986) |
| "Amodiaquine (AQ), an effective antimalarial drug for uncomplicated malaria, has been greatly restricted after cases of life-threatening agranulocytosis and hepatic toxicity during prophylactic use." | 5.13 | Biological and haematological safety profile of oral amodiaquine and chloroquine in healthy volunteers with or without Plasmodium falciparum infection in northeast Tanzania. ( Akida, JA; Bygbjerg, IC; Chile, MM; Kitua, AY; Lemnge, MM; Lusingu, JP; Makunde, R; Malebo, HM; Massaga, JJ; Rønn, AM; Theander, TG, 2008) |
| "Amodiaquine (AQ) is associated with a relatively high incidence of idiosyncratic drug-induced liver injury (IDILI) and agranulocytosis." | 3.83 | Exploring an animal model of amodiaquine-induced liver injury in rats and mice. ( Cai, P; Li, J; Liu, F; Metushi, I; Nakayawa, T; Uetrecht, J; Vega, L, 2016) |
| "Seven patients developed hepatitis after receiving amodiaquine for malaria prophylaxis for 4 to 15 weeks." | 3.67 | Amodiaquine-induced hepatitis. A report of seven cases. ( Benhamou, JP; Castot, A; Feldmann, G; Larrey, D; Lenoir, A; Machayekhy, JP; Merigot, P; Pëssayre, D; Rueff, B, 1986) |
| "Seven cases of agranulocytosis and two of liver damage that were probably due to amodiaquine treatment were studied." | 3.67 | Amodiaquine induced agranulocytosis and liver damage. ( Fehr, J; Frick, PG; Neftel, KA; Schmid, M; Woodtly, W, 1986) |
| "Three patients suffered from fulminant hepatitis within 23, 59 and 22 weeks after having ingested a total dose of 16, 26 and 15 g, respectively, of amodiaquine for the prophylaxis of malaria." | 3.67 | Amodiaquine-induced fulminant hepatitis. ( Benhamou, JP; Bernuau, J; Campillo, B; Degott, C; Larrey, D; Pessayre, D; Rueff, B; Verdier, F, 1988) |
| "Two patients are presented who during malaria prophylaxis with amodiaquine developed a hepatitis associated with granulocytopenia of short duration." | 3.67 | [Amodiaquine-induced hepatitis with leukopenia]. ( Siegrist, P; Vonmoos, P; Woodtli, W; Zollikofer, H, 1986) |
| "Amodiaquine (AQ) has been reported to cause severe idiosyncratic drug-induced liver injury (IDILI) in humans." | 1.42 | Immunization with amodiaquine-modified hepatic proteins prevents amodiaquine-induced liver injury. ( Mak, A; Uetrecht, J, 2015) |
| " Administration of radiolabeled AQ in combination with BSO exhibited significantly higher covalent binding to mice liver proteins than that observed after sole dosing of radiolabeled AQ." | 1.35 | Metabolism-dependent hepatotoxicity of amodiaquine in glutathione-depleted mice. ( Aoki, T; Atsumi, R; Itokawa, K; Iwasaki, M; Izumi, T; Okazaki, O; Ono, C; Shimizu, S; Sudo, K, 2009) |
| "Pretreatment with amodiaquine also improved the survival rate of the hepatitis mice, and this improvement was partially associated with the decrease in serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT)." | 1.34 | Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice. ( Kanke, T; Mori, S; Nishibori, M; Takahashi, HK; Wake, H; Yokoyama, A, 2007) |
| "Amodiaquine is an amino-4-quinoline with the basic spectrum of activity of chloroquine." | 1.34 | Emergency liver transplantation in amodiaquine-induced fulminant hepatitis. ( Desmeules, J; Giostra, E; Hadengue, A; Markham, LN; Rebsamen, M; Rossier, M, 2007) |
| " Dosage data indicated that fatalities had taken higher doses and continued prophylaxis after onset of symptoms." | 1.28 | Serious adverse drug reactions to pyrimethamine-sulphadoxine, pyrimethamine-dapsone and to amodiaquine in Britain. ( Phillips-Howard, PA; West, LJ, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (32.14) | 18.7374 |
| 1990's | 1 (3.57) | 18.2507 |
| 2000's | 7 (25.00) | 29.6817 |
| 2010's | 11 (39.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Zhang, Y | 1 |
| den Braver-Sewradj, SP | 1 |
| Vos, JC | 1 |
| Vermeulen, NPE | 1 |
| Commandeur, JNM | 1 |
| Mak, A | 6 |
| Cho, T | 1 |
| Uetrecht, J | 8 |
| Cho, TE | 1 |
| Metushi, IG | 1 |
| Hayes, MA | 1 |
| Peyre, L | 1 |
| de Sousa, G | 1 |
| Barcellini-Couget, S | 1 |
| Luzy, AP | 1 |
| Zucchini-Pascal, N | 1 |
| Rahmani, R | 1 |
| Liu, F | 1 |
| Cai, P | 1 |
| Metushi, I | 1 |
| Li, J | 1 |
| Nakayawa, T | 1 |
| Vega, L | 1 |
| Johnston, A | 1 |
| Guévart, E | 1 |
| Aguémon, A | 1 |
| Massaga, JJ | 1 |
| Lusingu, JP | 1 |
| Makunde, R | 1 |
| Malebo, HM | 1 |
| Chile, MM | 1 |
| Akida, JA | 1 |
| Lemnge, MM | 1 |
| Rønn, AM | 1 |
| Theander, TG | 1 |
| Bygbjerg, IC | 1 |
| Kitua, AY | 1 |
| Shimizu, S | 1 |
| Atsumi, R | 1 |
| Itokawa, K | 1 |
| Iwasaki, M | 1 |
| Aoki, T | 1 |
| Ono, C | 1 |
| Izumi, T | 1 |
| Sudo, K | 1 |
| Okazaki, O | 1 |
| Yokoyama, A | 1 |
| Mori, S | 1 |
| Takahashi, HK | 1 |
| Kanke, T | 1 |
| Wake, H | 1 |
| Nishibori, M | 1 |
| German, P | 1 |
| Greenhouse, B | 1 |
| Coates, C | 1 |
| Dorsey, G | 1 |
| Rosenthal, PJ | 1 |
| Charlebois, E | 1 |
| Lindegardh, N | 1 |
| Havlir, D | 1 |
| Aweeka, FT | 1 |
| Osorio, L | 1 |
| Gonzalez, I | 1 |
| Olliaro, P | 1 |
| Taylor, WR | 1 |
| Markham, LN | 1 |
| Giostra, E | 1 |
| Hadengue, A | 1 |
| Rossier, M | 1 |
| Rebsamen, M | 1 |
| Desmeules, J | 1 |
| Phillips-Howard, PA | 1 |
| West, LJ | 1 |
| Raymond, JM | 2 |
| Dumas, F | 2 |
| Baldit, C | 2 |
| Couzigou, P | 2 |
| Beraud, C | 2 |
| Amouretti, M | 2 |
| Larrey, D | 2 |
| Castot, A | 1 |
| Pëssayre, D | 2 |
| Merigot, P | 1 |
| Machayekhy, JP | 1 |
| Feldmann, G | 1 |
| Lenoir, A | 1 |
| Rueff, B | 2 |
| Benhamou, JP | 2 |
| Neftel, KA | 1 |
| Woodtly, W | 1 |
| Schmid, M | 1 |
| Frick, PG | 1 |
| Fehr, J | 1 |
| Bernuau, J | 1 |
| Campillo, B | 1 |
| Degott, C | 1 |
| Verdier, F | 1 |
| Maggs, JL | 1 |
| Kitteringham, NR | 1 |
| Breckenridge, AM | 1 |
| Park, BK | 1 |
| Charmot, G | 1 |
| Goujon, C | 1 |
| Desaint, B | 1 |
| Conrad, M | 1 |
| Florent, C | 1 |
| Legendre, C | 1 |
| Levy, VG | 1 |
| Woodtli, W | 1 |
| Vonmoos, P | 1 |
| Siegrist, P | 1 |
| Zollikofer, H | 1 |
2 trials available for amodiaquine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Biological and haematological safety profile of oral amodiaquine and chloroquine in healthy volunteers with or without Plasmodium falciparum infection in northeast Tanzania.
Topics: Adolescent; Adult; Agranulocytosis; Amodiaquine; Analysis of Variance; Animals; Antimalarials; Chemi | 2008 |
Artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Colombia.
Topics: Adolescent; Adult; Amodiaquine; Animals; Antimalarials; Artemisinins; Artesunate; Bone Marrow Diseas | 2007 |
26 other studies available for amodiaquine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: Possible implications for susceptibility to amodiaquine-induced liver toxicity.
Topics: Amodiaquine; Biocatalysis; Chemical and Drug Induced Liver Injury; Escherichia coli; Glutathione Tra | 2017 |
Use of an animal model to test whether non-alcoholic fatty liver disease increases the risk of idiosyncratic drug-induced liver injury.
Topics: Amodiaquine; Animals; Antibodies, Blocking; Chemical and Drug Induced Liver Injury; Choline Deficien | 2018 |
The Effects of Immune Modulators on Amodiaquine-Induced Liver Injury.
Topics: Adjuvants, Immunologic; Amodiaquine; Animals; Antimalarials; Chemical and Drug Induced Liver Injury; | 2018 |
Involvement of CCL2/CCR2 macrophage recruitment in amodiaquine-induced liver injury.
Topics: Amodiaquine; Animals; CD8-Positive T-Lymphocytes; Chemical and Drug Induced Liver Injury; Chemokine | 2019 |
Treatment of PD-1(-/-) mice with amodiaquine and anti-CTLA4 leads to liver injury similar to idiosyncratic liver injury in patients.
Topics: Amodiaquine; Animals; Antibodies; Chemical and Drug Induced Liver Injury; CTLA-4 Antigen; Disease Mo | 2015 |
Immunization with amodiaquine-modified hepatic proteins prevents amodiaquine-induced liver injury.
Topics: Amodiaquine; Animals; Chemical and Drug Induced Liver Injury; Female; Forkhead Transcription Factors | 2015 |
The Role of CD8 T Cells in Amodiaquine-Induced Liver Injury in PD1-/- Mice Cotreated with Anti-CTLA-4.
Topics: Amodiaquine; Animals; Antibodies, Monoclonal; Blotting, Western; CD8-Positive T-Lymphocytes; Chemica | 2015 |
High-content screening imaging and real-time cellular impedance monitoring for the assessment of chemical's bio-activation with regards hepatotoxicity.
Topics: Acetaminophen; Amodiaquine; Animals; Carbamazepine; Cell Line, Tumor; Cell Survival; Cells, Cultured | 2015 |
Exploring an animal model of amodiaquine-induced liver injury in rats and mice.
Topics: Agranulocytosis; Amodiaquine; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cycl | 2016 |
Effects of immunization and checkpoint inhibition on amodiaquine-induced liver injury.
Topics: Amodiaquine; Animals; Antibodies, Monoclonal; CD40 Antigens; Cells, Cultured; Chemical and Drug Indu | 2017 |
[Two cases of fulminant hepatitis during a curative treatment with an artesunate-amodiaquine combination].
Topics: Adult; Amodiaquine; Antimalarials; Artemisinins; Artesunate; Chemical and Drug Induced Liver Injury; | 2009 |
Metabolism-dependent hepatotoxicity of amodiaquine in glutathione-depleted mice.
Topics: Alanine Transaminase; Amodiaquine; Animals; Antimalarials; Buthionine Sulfoximine; Chemical and Drug | 2009 |
Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice.
Topics: Alanine Transaminase; Amodiaquine; Animals; Aspartate Aminotransferases; Chemical and Drug Induced L | 2007 |
Hepatotoxicity due to a drug interaction between amodiaquine plus artesunate and efavirenz.
Topics: Adult; Alkynes; Amodiaquine; Artemisinins; Artesunate; Benzoxazines; Chemical and Drug Induced Liver | 2007 |
Emergency liver transplantation in amodiaquine-induced fulminant hepatitis.
Topics: Adult; Amodiaquine; Antimalarials; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; | 2007 |
Serious adverse drug reactions to pyrimethamine-sulphadoxine, pyrimethamine-dapsone and to amodiaquine in Britain.
Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Chemical and Drug Induced Liver Injury; Child; Child, | 1990 |
Fatal acute hepatitis due to amodiaquine.
Topics: Adult; Amodiaquine; Chemical and Drug Induced Liver Injury; Female; Humans; Malaria | 1989 |
Amodiaquine-induced hepatitis. A report of seven cases.
Topics: Adult; Alanine Transaminase; Amodiaquine; Aspartate Aminotransferases; Asthenia; Chemical and Drug I | 1986 |
Amodiaquine induced agranulocytosis and liver damage.
Topics: Adolescent; Adult; Aged; Agranulocytosis; Amodiaquine; Chemical and Drug Induced Liver Injury; Femal | 1986 |
Amodiaquine-induced fulminant hepatitis.
Topics: Adolescent; Adult; Amodiaquine; Chemical and Drug Induced Liver Injury; Female; Humans; Malaria; Mal | 1988 |
Autoxidative formation of a chemically reactive intermediate from amodiaquine, a myelotoxin and hepatotoxin in man.
Topics: Amodiaquine; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Humans; Muscular | 1987 |
[Minor hepatitis probably caused by amodiaquine].
Topics: Amodiaquine; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Humans | 1987 |
[Is amodiaquine (Flavoquine) hepatotoxic?].
Topics: Adult; Amodiaquine; Chemical and Drug Induced Liver Injury; Female; Humans | 1986 |
[Amodiaquine-induced hepatitis with leukopenia].
Topics: Adult; Agranulocytosis; Amodiaquine; Chemical and Drug Induced Liver Injury; Diagnosis, Differential | 1986 |
[Amodiaquine (Flavoquine) is hepatotoxic].
Topics: Acute Disease; Adult; Amodiaquine; Chemical and Drug Induced Liver Injury; Female; Humans | 1986 |