Page last updated: 2024-10-22

amodiaquine and Anemia

amodiaquine has been researched along with Anemia in 29 studies

Amodiaquine: A 4-aminoquinoline compound with anti-inflammatory properties.
amodiaquine : A quinoline having a chloro group at the 7-position and an aryl amino group at the 4-position.

Anemia: A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.

Research Excerpts

ExcerptRelevanceReference
"The therapeutic efficacy and effects of artemether-lumefantrine (AL) and artesunate-amodiaquine co-formulated (AAcf) or co-packaged (AAcp) on malaria-associated anemia (MAA) were evaluated in 285 children < 12 years of age with uncomplicated Plasmodium falciparum malaria randomized to receive one of the three drug combinations."9.15Therapeutic efficacy and effects of artemether-lumefantrine and artesunate-amodiaquine coformulated or copackaged on malaria-associated anemia in children with uncomplicated Plasmodium falciparum malaria in Southwest Nigeria. ( Adewoye, EO; Folarin, OA; Gbotosho, GO; Happi, CT; Michael, OS; Okuboyejo, TM; Sowunmi, A, 2011)
"The effects of amodiaquine, artesunate and artesunate-amodiaquine on Plasmodium falciparum malaria-associated anaemia (PfMAA) and the recovery from PfMAA were evaluated in 328 children with uncomplicated malaria randomized to the standard dose regimens of the three drug treatments."9.14Effects of amodiaquine, artesunate, and artesunate-amodiaquine on Plasmodium falciparum malaria-associated anaemia in children. ( Balogun, ST; Gbotosho, GO; Happi, CT; Sowunmi, A, 2009)
"Intermittent preventive treatment of malaria among schoolchildren (IPTsc) reduces clinical malaria, asymptomatic parasitemia, and anemia."7.11Overall and Gender-Specific Effects of Intermittent Preventive Treatment of Malaria with Artemisinin-Based Combination Therapies among Schoolchildren in Mali: A Three-Group Open Label Randomized Controlled Trial. ( Bamadio, A; Chico, RM; Cohee, LM; Coumare, S; Dara, A; Diarra, M; Djimde, AA; Doumbo, OK; Kodio, A; Maiga, H; Opondo, C; Sagara, I; Sidibe, B; Tekete, M; Traore, OB; Traore, ZI, 2022)
"Community health workers in Dangme-West district, Ghana, treated children aged 2-59 months with fever with either artesunate-amodiaquine (AAQ) or AAQ plus amoxicillin (AAQ + AMX) within a cluster-randomized controlled trial (registration no."5.17Impact of treating young children with antimalarials with or without antibiotics on morbidity: a cluster-randomized controlled trial in Ghana. ( Abbey, M; Adjuik, M; Chinbuah, MA; Cobelens, F; Gyapong, JO; Gyapong, M; Kager, PA; Koram, KA, 2013)
"The therapeutic efficacy and effects of artemether-lumefantrine (AL) and artesunate-amodiaquine co-formulated (AAcf) or co-packaged (AAcp) on malaria-associated anemia (MAA) were evaluated in 285 children < 12 years of age with uncomplicated Plasmodium falciparum malaria randomized to receive one of the three drug combinations."5.15Therapeutic efficacy and effects of artemether-lumefantrine and artesunate-amodiaquine coformulated or copackaged on malaria-associated anemia in children with uncomplicated Plasmodium falciparum malaria in Southwest Nigeria. ( Adewoye, EO; Folarin, OA; Gbotosho, GO; Happi, CT; Michael, OS; Okuboyejo, TM; Sowunmi, A, 2011)
"The effects of amodiaquine, artesunate and artesunate-amodiaquine on Plasmodium falciparum malaria-associated anaemia (PfMAA) and the recovery from PfMAA were evaluated in 328 children with uncomplicated malaria randomized to the standard dose regimens of the three drug treatments."5.14Effects of amodiaquine, artesunate, and artesunate-amodiaquine on Plasmodium falciparum malaria-associated anaemia in children. ( Balogun, ST; Gbotosho, GO; Happi, CT; Sowunmi, A, 2009)
"The use of sulfadoxine-pyrimethamine (SP) for intermittent preventive treatment in pregnancy (IPTp) is threatened by the spread of resistance to SP."5.13A randomized, controlled trial of intermittent preventive treatment with sulfadoxine-pyrimethamine, amodiaquine, or the combination in pregnant women in Ghana. ( Affipunguh, PK; Bruce, J; Chandramohan, D; Clerk, CA; Greenwood, B; Hodgson, A; Mensah, N, 2008)
"Monthly artesunate plus amodiaquine reduced the incidence of malaria by 69% (95% CI: 63%, 74%) and anaemia by 45% (95% CI: 25%,60%), bimonthly sulphadoxine-pyrimethamine reduced the incidence of malaria by 24% (95% CI: 14%,33%) and anaemia by 30% (95% CI: 6%, 49%) and bimonthly artesunate plus amodiaquine reduced the incidence of malaria by 17% (95% CI: 6%, 27%) and anaemia by 32% (95% CI: 7%, 50%) compared to placebo."5.13Seasonal intermittent preventive treatment for the prevention of anaemia and malaria in Ghanaian children: a randomized, placebo controlled trial. ( Adjuik, M; Binka, F; Chandramohan, D; Greenwood, B; Kweku, M; Liu, D; Seidu, M, 2008)
"Intermittent preventive treatment of malaria among schoolchildren (IPTsc) reduces clinical malaria, asymptomatic parasitemia, and anemia."3.11Overall and Gender-Specific Effects of Intermittent Preventive Treatment of Malaria with Artemisinin-Based Combination Therapies among Schoolchildren in Mali: A Three-Group Open Label Randomized Controlled Trial. ( Bamadio, A; Chico, RM; Cohee, LM; Coumare, S; Dara, A; Diarra, M; Djimde, AA; Doumbo, OK; Kodio, A; Maiga, H; Opondo, C; Sagara, I; Sidibe, B; Tekete, M; Traore, OB; Traore, ZI, 2022)
" CF fortified with highly bioavailable iron improved iron status but not Hb concentration, despite three-monthly IPT of malaria."2.80The effect of iron-fortified complementary food and intermittent preventive treatment of malaria on anaemia in 12- to 36-month-old children: a cluster-randomised controlled trial. ( Adiossan, LG; Brittenham, GM; Diakité, VG; Glinz, D; Hurrell, RF; N'Goran, EK; Ouattara, M; Righetti, AA; Seifert, B; Utzinger, J; Wegmüller, R; Zimmermann, MB, 2015)
"Intermittent preventive treatment for malaria in children (IPTc) involves the administration of a full course of an anti-malarial treatment to children under 5 years old at specified time points regardless of whether or not they are known to be infected, in areas where malaria transmission is seasonal."2.75Cost effectiveness of seasonal intermittent preventive treatment using amodiaquine & artesunate or sulphadoxine-pyrimethamine in Ghanaian children. ( Chandramohan, D; Conteh, L; Greenwood, B; Kweku, M; Legood, R; Patouillard, E, 2010)
" Reappraisal of quinine therapy has led to important modifications in dosage recommendations and recognition of a major complication of severe malaria associated with its use--hypoglycaemia."1.27Management of Plasmodium falciparum malaria. ( Phillips, RE, 1984)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19902 (6.90)18.7374
1990's0 (0.00)18.2507
2000's9 (31.03)29.6817
2010's17 (58.62)24.3611
2020's1 (3.45)2.80

Authors

AuthorsStudies
Maiga, H1
Opondo, C1
Chico, RM1
Cohee, LM1
Sagara, I2
Traore, OB1
Tekete, M1
Dara, A1
Traore, ZI1
Diarra, M1
Coumare, S1
Kodio, A1
Bamadio, A1
Sidibe, B1
Doumbo, OK2
Djimde, AA2
Akano, K7
Fatunmbi, B8
Ntadom, G8
Ayede, AI6
Aderoyeje, T6
Bakre, A1
Alebiosu, OT1
Akpoborie, O1
Okafor, C1
Gbotosho, GO7
Folarin, OA4
Ebenebe, JC1
Ambe, J2
Wammanda, R2
Jiya, N2
Finomo, F2
Emechebe, G2
Mokuolu, O2
Agomo, C5
Oguche, S5
Happi, C2
Sowunmi, A12
Ayede, A1
Okafor, H1
Watila, I3
Meremikwu, M3
Ogala, W3
Agomo, P3
Adowoye, E1
Gbotosho, G1
Folarin, O2
Diawara, F1
Steinhardt, LC1
Mahamar, A1
Traore, T1
Kone, DT1
Diawara, H1
Kamate, B1
Kone, D1
Diallo, M1
Sadou, A1
Mihigo, J1
Eckert, E1
Dicko, A2
Wewe, OA1
Ebenebe, J1
Ezeigwe, N1
Adewoye, EO6
Happi, CT6
Oyibo, WA1
Useh, F1
Chinbuah, MA1
Adjuik, M2
Cobelens, F1
Koram, KA1
Abbey, M1
Gyapong, M1
Kager, PA1
Gyapong, JO1
Okafor, HU2
Banjo, O1
Okuboyejo, T2
Ogunrinde, G1
Odey, F1
Aina, O1
Sofola, T1
Glinz, D1
Hurrell, RF1
Ouattara, M1
Zimmermann, MB1
Brittenham, GM1
Adiossan, LG1
Righetti, AA1
Seifert, B1
Diakité, VG1
Utzinger, J1
N'Goran, EK1
Wegmüller, R1
Ibironke, FO1
Clarke, SE1
Jukes, MC1
Njagi, JK1
Khasakhala, L1
Cundill, B1
Otido, J1
Crudder, C1
Estambale, BB1
Brooker, S1
Clerk, CA1
Bruce, J1
Affipunguh, PK1
Mensah, N1
Hodgson, A1
Greenwood, B4
Chandramohan, D5
Balogun, ST2
Kweku, M2
Liu, D1
Binka, F1
Seidu, M1
Billal, DS1
Hotomi, M1
Yamanaka, N1
Michael, O1
Conteh, L1
Patouillard, E1
Legood, R1
Okuboyejo, TM1
Michael, OS1
Konaté, AT1
Yaro, JB1
Ouédraogo, AZ1
Diarra, A1
Gansané, A1
Soulama, I1
Kangoyé, DT1
Kaboré, Y1
Ouédraogo, E1
Ouédraogo, A1
Tiono, AB1
Ouédraogo, IN1
Cousens, S2
Milligan, PJ2
Sirima, SB1
Greenwood, BM1
Diallo, DA2
Barry, A1
Dicko, M1
Diallo, AI1
Tembine, I1
Dicko, Y1
Dara, N1
Sidibe, Y1
Santara, G1
Conaré, T1
Tine, RC1
Faye, B1
Ndour, CT1
Ndiaye, JL1
Ndiaye, M1
Bassene, C1
Magnussen, P1
Bygbjerg, IC1
Sylla, K1
Ndour, JD1
Gaye, O1
DAVID, HL1
Lemnge, MM1
Ali, AS1
Malecela, EK1
Sambu, E1
Abdulla, R1
Juma, MS1
Fakih, K1
Abdulla, KH1
Njau, RJ1
Quashie, NB1
Akanmori, BD1
Ofori-Adjei, D1
Goka, BQ1
Kurtzhals, JA1
Patrick Kachur, S1
Schulden, J1
Goodman, CA1
Kassala, H1
Elling, BF1
Khatib, RA1
Causer, LM1
Mkikima, S1
Abdulla, S1
Bloland, PB1
Phillips, RE1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Measuring the Impact of Seasonal Malaria Chemoprevention as Part of Routine Malaria Control in Kita, Mali[NCT02894294]1,162 participants (Actual)Observational [Patient Registry]2014-07-31Completed
Aetiology, Prevention and Control of Anaemia in Sub-Saharan Africa - Work Package 2: Efficacy Study: Efficacy of 2 Iron Fortified Porridges and IPT for the Prevention of Anemia in Young Children in Côte d'Ivoire.[NCT01634945]629 participants (Actual)Interventional2012-04-30Completed
Intermittent Preventive Treatment in Schools: a Randomised Controlled Trial of the Impact of IPT on Malaria, Anaemia and Education Amongst Schoolchildren in Western Kenya[NCT00142246]Phase 36,758 participants (Actual)Interventional2005-01-31Completed
Efficacy of Sulphadoxine-pyrimethamine and Amodiaquine Alone or in Combination as Intermittent Preventive Treatment in Pregnancy in the Kassena-Nankana District of Ghana: a Randomized Controlled Trial[NCT00146783]Phase 2/Phase 33,642 participants (Actual)Interventional2004-06-30Completed
A Study Of Impact Of Intermittent Preventive Treatment In Children With Amodiaquine Plus Artesunate Versus Sulphadoxine-Pyrimethamine On Hemoglobin Levels And Malaria Morbidity In Hohoe District Of Ghana[NCT00119132]Phase 2/Phase 32,602 participants (Actual)Interventional2005-06-30Completed
A Trial of the Combined Impact of Intermittent Preventive Treatment and Insecticide Treated Bednets in Reducing Morbidity From Malaria in African Children[NCT00738946]6,000 participants (Anticipated)Interventional2008-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

17 trials available for amodiaquine and Anemia

ArticleYear
Overall and Gender-Specific Effects of Intermittent Preventive Treatment of Malaria with Artemisinin-Based Combination Therapies among Schoolchildren in Mali: A Three-Group Open Label Randomized Controlled Trial.
    The American journal of tropical medicine and hygiene, 2022, 10-12, Volume: 107, Issue:4

    Topics: Amodiaquine; Anemia; Antimalarials; Artemisinins; Artesunate; Child; Drug Combinations; Drug Therapy

2022
Impact of treating young children with antimalarials with or without antibiotics on morbidity: a cluster-randomized controlled trial in Ghana.
    International health, 2013, Volume: 5, Issue:3

    Topics: Amodiaquine; Amoxicillin; Anemia; Anti-Bacterial Agents; Antimalarials; Artemisinins; Caregivers; Ch

2013
Efficacy of artemisinin-based combination treatments of uncomplicated falciparum malaria in under-five-year-old Nigerian children.
    The American journal of tropical medicine and hygiene, 2014, Volume: 91, Issue:5

    Topics: Amodiaquine; Anemia; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Child,

2014
The effect of iron-fortified complementary food and intermittent preventive treatment of malaria on anaemia in 12- to 36-month-old children: a cluster-randomised controlled trial.
    Malaria journal, 2015, Sep-17, Volume: 14

    Topics: Amodiaquine; Anemia; Antimalarials; Child, Preschool; Cote d'Ivoire; Diphosphates; Drug Combinations

2015
Temporal changes in haematocrit following artemisinin-based combination treatments of uncomplicated falciparum malaria in children.
    BMC infectious diseases, 2015, Oct-26, Volume: 15

    Topics: Administration, Intravenous; Adolescent; Amodiaquine; Anemia; Antimalarials; Artemether, Lumefantrin

2015
Clinical illness and outcomes in Nigerian children with late-appearing anaemia after artemisinin-based combination treatments of uncomplicated falciparum malaria.
    BMC infectious diseases, 2016, 06-01, Volume: 16

    Topics: Adolescent; Amodiaquine; Anemia; Antimalarials; Artemisinins; Child; Child, Preschool; Drug Combinat

2016
Effect of intermittent preventive treatment of malaria on health and education in schoolchildren: a cluster-randomised, double-blind, placebo-controlled trial.
    Lancet (London, England), 2008, Jul-12, Volume: 372, Issue:9633

    Topics: Adolescent; Amodiaquine; Anemia; Animals; Antimalarials; Child; Child, Preschool; Cluster Analysis;

2008
A randomized, controlled trial of intermittent preventive treatment with sulfadoxine-pyrimethamine, amodiaquine, or the combination in pregnant women in Ghana.
    The Journal of infectious diseases, 2008, Oct-15, Volume: 198, Issue:8

    Topics: Amodiaquine; Anemia; Animals; Antimalarials; Child, Preschool; Drug Combinations; Drug Therapy, Comb

2008
Effects of amodiaquine, artesunate, and artesunate-amodiaquine on Plasmodium falciparum malaria-associated anaemia in children.
    Acta tropica, 2009, Volume: 109, Issue:1

    Topics: Amodiaquine; Anemia; Animals; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Drug

2009
Seasonal intermittent preventive treatment for the prevention of anaemia and malaria in Ghanaian children: a randomized, placebo controlled trial.
    PloS one, 2008, Volume: 3, Issue:12

    Topics: Amodiaquine; Anemia; Antimalarials; Artemisinins; Artesunate; Child, Preschool; Drug Combinations; G

2008
Use of area under the curve to evaluate the effects of antimalarial drugs on malaria-associated anemia after treatment.
    American journal of therapeutics, 2011, Volume: 18, Issue:3

    Topics: Amodiaquine; Anemia; Antimalarials; Area Under Curve; Artemether, Lumefantrine Drug Combination; Art

2011
Cost effectiveness of seasonal intermittent preventive treatment using amodiaquine & artesunate or sulphadoxine-pyrimethamine in Ghanaian children.
    PloS one, 2010, Aug-17, Volume: 5, Issue:8

    Topics: Amodiaquine; Anemia; Antimalarials; Artemisinins; Artesunate; Child, Preschool; Cost-Benefit Analysi

2010
Therapeutic efficacy and effects of artemether-lumefantrine and artesunate-amodiaquine coformulated or copackaged on malaria-associated anemia in children with uncomplicated Plasmodium falciparum malaria in Southwest Nigeria.
    The American journal of tropical medicine and hygiene, 2011, Volume: 84, Issue:5

    Topics: Amodiaquine; Anemia; Antimalarials; Area Under Curve; Artemether, Lumefantrine Drug Combination; Art

2011
Morbidity from malaria in children in the year after they had received intermittent preventive treatment of malaria: a randomised trial.
    PloS one, 2011, Volume: 6, Issue:8

    Topics: Amodiaquine; Anemia; Antimalarials; Body Weight; Burkina Faso; Child, Preschool; Double-Blind Method

2011
Malaria morbidity in children in the year after they had received intermittent preventive treatment of malaria in Mali: a randomized control trial.
    PloS one, 2011, Volume: 6, Issue:8

    Topics: Amodiaquine; Anemia; Antimalarials; Body Weight; Child, Preschool; Drug Administration Schedule; Dru

2011
Impact of combining intermittent preventive treatment with home management of malaria in children less than 10 years in a rural area of Senegal: a cluster randomized trial.
    Malaria journal, 2011, Dec-13, Volume: 10

    Topics: Amodiaquine; Anemia; Animals; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; C

2011
Therapeutic efficacy of sulfadoxine-pyrimethamine and amodiaquine among children with uncomplicated Plasmodium falciparum malaria in Zanzibar, Tanzania.
    The American journal of tropical medicine and hygiene, 2005, Volume: 73, Issue:4

    Topics: Amodiaquine; Anemia; Animals; Antimalarials; Child, Preschool; Drug Combinations; Drug Resistance; H

2005

Other Studies

12 other studies available for amodiaquine and Anemia

ArticleYear
Clinical illness and outcomes in Nigerian children with persistent early-appearing anaemia following initiation of artemisinin-based combination treatments of uncomplicated falciparum malaria.
    Parasite (Paris, France), 2019, Volume: 26

    Topics: Amodiaquine; Anemia; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Child,

2019
Anaemia following Artemisinin-Based Combination Treatments of Uncomplicated Plasmodium falciparum Malaria in Children: Temporal Patterns of Haematocrit and the Use of Uncomplicated Hyperparasitaemia as a Model for Evaluating Late-Appearing Anaemia.
    Chemotherapy, 2017, Volume: 62, Issue:4

    Topics: Amodiaquine; Anemia; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Child;

2017
Measuring the impact of seasonal malaria chemoprevention as part of routine malaria control in Kita, Mali.
    Malaria journal, 2017, 08-10, Volume: 16, Issue:1

    Topics: Amodiaquine; Anemia; Antimalarials; Chemoprevention; Child; Child, Preschool; Cross-Sectional Studie

2017
Factors contributing to anaemia after uncomplicated falciparum malaria in under five year-old Nigerian children ten years following adoption of artemisinin-based combination therapies as first-line antimalarials.
    BMC infectious diseases, 2017, 12-19, Volume: 17, Issue:1

    Topics: Amodiaquine; Anemia; Antimalarials; Area Under Curve; Artemisinins; Child, Preschool; Drug Combinati

2017
Therapeutic efficacy and effects of artesunate-amodiaquine and artemether-lumefantrine on malaria-associated anaemia in Nigerian children aged two years and under.
    Infectious diseases of poverty, 2016, Jul-06, Volume: 5, Issue:1

    Topics: Amodiaquine; Anemia; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Child,

2016
Therapeutic efficacy and effects of artemisinin-based combination treatments on uncomplicated Plasmodium falciparum malaria -associated anaemia in Nigerian children during seven years of adoption as first-line treatments.
    Infectious diseases of poverty, 2017, Feb-07, Volume: 6, Issue:1

    Topics: Adolescent; Amodiaquine; Anemia; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisin

2017
Plasmodium falciparum gametocyte sex ratios in children with acute, symptomatic, uncomplicated infections treated with amodiaquine.
    Malaria journal, 2008, Sep-02, Volume: 7

    Topics: Africa; Amodiaquine; Anemia; Animals; Child; Child, Preschool; Female; Humans; Infant; Kaplan-Meier

2008
Intermittent preventive treatment with antimalarial drugs.
    Lancet (London, England), 2009, Jan-03, Volume: 373, Issue:9657

    Topics: Amodiaquine; Anemia; Antimalarials; Drug Administration Schedule; Drug Combinations; Humans; Infant;

2009
SOME FEATURES OF MALARIA IN DILI, PORTUGUESE TIMOR, DURING 1963-64.
    Annals of tropical medicine and parasitology, 1965, Volume: 59

    Topics: Amodiaquine; Anemia; Chloroquine; Clinical Laboratory Techniques; Drug Therapy; Epidemiology; Humans

1965
Factors contributing to the development of anaemia in Plasmodium falciparum malaria: what about drug-resistant parasites?
    Journal of tropical pediatrics, 2006, Volume: 52, Issue:4

    Topics: Amodiaquine; Anemia; Animals; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; Drug R

2006
Prevalence of malaria parasitemia among clients seeking treatment for fever or malaria at drug stores in rural Tanzania 2004.
    Tropical medicine & international health : TM & IH, 2006, Volume: 11, Issue:4

    Topics: Adult; Amodiaquine; Analgesics, Non-Narcotic; Anemia; Antimalarials; Child, Preschool; Drug Combinat

2006
Management of Plasmodium falciparum malaria.
    The Medical journal of Australia, 1984, Oct-13, Volume: 141, Issue:8

    Topics: Amodiaquine; Anemia; Antimalarials; Brain Diseases; Chloroquine; Drug Resistance; Female; Humans; Hy

1984