amodiaquine has been researched along with Agranulocytosis in 24 studies
Amodiaquine: A 4-aminoquinoline compound with anti-inflammatory properties.
amodiaquine : A quinoline having a chloro group at the 7-position and an aryl amino group at the 4-position.
Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Agranulocytosis seen with (i) beta-Lactam-antibiotics, (ii) vancomycin and (iii) amodiaquine can exemplify how simultaneous investigations of epidemiological and experimental aspects lead to identification of a subpopulation at risk." | 8.78 | [Evaluation of hematologic side effects of anti-infective therapy: agranulocytosis caused by beta-lactam antibiotics, vancomycin and amodiaquine]. ( Eich, G; Neftel, KA, 1991) |
| "Amodiaquine (AQ) and clozapine (CLZ) are associated with a relatively high incidence of idiosyncratic agranulocytosis, a reaction that is suspected to involve covalent binding of reactive metabolites to neutrophils." | 7.80 | Involvement of myeloperoxidase and NADPH oxidase in the covalent binding of amodiaquine and clozapine to neutrophils: implications for drug-induced agranulocytosis. ( Lobach, AR; Uetrecht, J, 2014) |
| "We report a case of amodiaquine-induced agranulocytosis in a 60-year-old woman." | 7.67 | Amodiaquine-induced agranulocytosis: report of a case with in vitro studies of granulocyte-macrophage progenitor cells. ( Aymard, JP; Ferry, R; Janot, C; Legras, B; May, T; Rouveix, B; Streiff, F, 1989) |
| "6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken cotrimoxazole and another had taken sulphaguanidine." | 7.67 | Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria. ( Bunch, C; Edwards, G; Hatton, CS; Pasvol, G; Peto, TE; Russell, SJ; Singer, CR; Winstanley, P, 1986) |
| "This report describes two patients who developed agranulocytosis while receiving prophylactic amodiaquine treatment." | 7.67 | Amodiaquine-induced immune agranulocytosis. ( Abel, L; Aymard, JP; Chau, F; Coulombel, L; Rouveix, B, 1989) |
| "Bone marrow was cultured in vitro for colonies of granulocytes and macrophages five months after a patient had recovered from amodiaquine induced agranulocytosis." | 7.67 | Amodiaquine induced agranulocytosis: inhibition of colony growth in bone marrow by antimalarial agents. ( Ball, J; Franklin, IM; Rhodes, EG, 1986) |
| "Seven cases of agranulocytosis and two of liver damage that were probably due to amodiaquine treatment were studied." | 7.67 | Amodiaquine induced agranulocytosis and liver damage. ( Fehr, J; Frick, PG; Neftel, KA; Schmid, M; Woodtly, W, 1986) |
| "Two patients are presented who during malaria prophylaxis with amodiaquine developed a hepatitis associated with granulocytopenia of short duration." | 7.67 | [Amodiaquine-induced hepatitis with leukopenia]. ( Siegrist, P; Vonmoos, P; Woodtli, W; Zollikofer, H, 1986) |
| "We report a patient who developed agranulocytosis following exposure to three drugs: amodiaquine, pyrimethamine and dipyrone." | 7.67 | Amodiaquine-induced agranulocytosis: drug inhibition of myeloid colonies in the presence of patient's serum. ( Douer, D; Ramot, B; Schwartz, E; Shaked, N, 1985) |
| "A patient is presented who developed agranulocytosis while taking amodiaquine for suppressive therapy of malaria." | 7.66 | [Amodiaquine-induced agranulocytosis in malaria prevention: demonstration of an amodiaquine-induced cytotoxic antibody against granulocytes]. ( Gmür, J; Neftel, K; Schulthess, HK; von Felten, A, 1983) |
| "A case of profound neutropenia and severe infection after the administration of amodiaquine is presented." | 7.65 | Amodiaquine agranulocytosis. ( Gillespie, P; Wagner, F, 1977) |
| "A case of agranulocytosis is reported in which amodiaquine, to which the patient had been exposed, was found to be toxic to the patient's bone marrow cells when these were cultured in an agar colony system in vitro." | 7.65 | Amodiaquine-induced agranulocytosis: toxic effect of amodiaquine in bone marrow cultures in vitro. ( Levi, JA; Lind, DE; Vincent, PC, 1973) |
| "Amodiaquine (AQ), an effective antimalarial drug for uncomplicated malaria, has been greatly restricted after cases of life-threatening agranulocytosis and hepatic toxicity during prophylactic use." | 5.13 | Biological and haematological safety profile of oral amodiaquine and chloroquine in healthy volunteers with or without Plasmodium falciparum infection in northeast Tanzania. ( Akida, JA; Bygbjerg, IC; Chile, MM; Kitua, AY; Lemnge, MM; Lusingu, JP; Makunde, R; Malebo, HM; Massaga, JJ; Rønn, AM; Theander, TG, 2008) |
| " Agranulocytosis seen with (i) beta-Lactam-antibiotics, (ii) vancomycin and (iii) amodiaquine can exemplify how simultaneous investigations of epidemiological and experimental aspects lead to identification of a subpopulation at risk." | 4.78 | [Evaluation of hematologic side effects of anti-infective therapy: agranulocytosis caused by beta-lactam antibiotics, vancomycin and amodiaquine]. ( Eich, G; Neftel, KA, 1991) |
| "Amodiaquine (AQ) is associated with a relatively high incidence of idiosyncratic drug-induced liver injury (IDILI) and agranulocytosis." | 3.83 | Exploring an animal model of amodiaquine-induced liver injury in rats and mice. ( Cai, P; Li, J; Liu, F; Metushi, I; Nakayawa, T; Uetrecht, J; Vega, L, 2016) |
| "Amodiaquine (AQ) and clozapine (CLZ) are associated with a relatively high incidence of idiosyncratic agranulocytosis, a reaction that is suspected to involve covalent binding of reactive metabolites to neutrophils." | 3.80 | Involvement of myeloperoxidase and NADPH oxidase in the covalent binding of amodiaquine and clozapine to neutrophils: implications for drug-induced agranulocytosis. ( Lobach, AR; Uetrecht, J, 2014) |
| "6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken cotrimoxazole and another had taken sulphaguanidine." | 3.67 | Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria. ( Bunch, C; Edwards, G; Hatton, CS; Pasvol, G; Peto, TE; Russell, SJ; Singer, CR; Winstanley, P, 1986) |
| "This report describes two patients who developed agranulocytosis while receiving prophylactic amodiaquine treatment." | 3.67 | Amodiaquine-induced immune agranulocytosis. ( Abel, L; Aymard, JP; Chau, F; Coulombel, L; Rouveix, B, 1989) |
| "Bone marrow was cultured in vitro for colonies of granulocytes and macrophages five months after a patient had recovered from amodiaquine induced agranulocytosis." | 3.67 | Amodiaquine induced agranulocytosis: inhibition of colony growth in bone marrow by antimalarial agents. ( Ball, J; Franklin, IM; Rhodes, EG, 1986) |
| "Seven cases of agranulocytosis and two of liver damage that were probably due to amodiaquine treatment were studied." | 3.67 | Amodiaquine induced agranulocytosis and liver damage. ( Fehr, J; Frick, PG; Neftel, KA; Schmid, M; Woodtly, W, 1986) |
| "Bone-marrow culture in soft agar was used to determine the cause of neutropenia in a visitor to Tanzania who had been taking both amodiaquine and proguanil for antimalarial prophylaxis." | 3.67 | Neutropenia associated with dual antimalarial chemoprophylaxis--use of bone-marrow culture as an aid in further drug management. ( Addison, GM; Ellis, ME; Steed, AJ, 1987) |
| "Two patients are presented who during malaria prophylaxis with amodiaquine developed a hepatitis associated with granulocytopenia of short duration." | 3.67 | [Amodiaquine-induced hepatitis with leukopenia]. ( Siegrist, P; Vonmoos, P; Woodtli, W; Zollikofer, H, 1986) |
| "We report a patient who developed agranulocytosis following exposure to three drugs: amodiaquine, pyrimethamine and dipyrone." | 3.67 | Amodiaquine-induced agranulocytosis: drug inhibition of myeloid colonies in the presence of patient's serum. ( Douer, D; Ramot, B; Schwartz, E; Shaked, N, 1985) |
| "A patient is presented who developed agranulocytosis while taking amodiaquine for suppressive therapy of malaria." | 3.66 | [Amodiaquine-induced agranulocytosis in malaria prevention: demonstration of an amodiaquine-induced cytotoxic antibody against granulocytes]. ( Gmür, J; Neftel, K; Schulthess, HK; von Felten, A, 1983) |
| "A case of profound neutropenia and severe infection after the administration of amodiaquine is presented." | 3.65 | Amodiaquine agranulocytosis. ( Gillespie, P; Wagner, F, 1977) |
| "A case of agranulocytosis is reported in which amodiaquine, to which the patient had been exposed, was found to be toxic to the patient's bone marrow cells when these were cultured in an agar colony system in vitro." | 3.65 | Amodiaquine-induced agranulocytosis: toxic effect of amodiaquine in bone marrow cultures in vitro. ( Levi, JA; Lind, DE; Vincent, PC, 1973) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (83.33) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 2 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lobach, AR | 1 |
| Uetrecht, J | 2 |
| Liu, F | 1 |
| Cai, P | 1 |
| Metushi, I | 1 |
| Li, J | 1 |
| Nakayawa, T | 1 |
| Vega, L | 1 |
| Massaga, JJ | 1 |
| Lusingu, JP | 1 |
| Makunde, R | 1 |
| Malebo, HM | 1 |
| Chile, MM | 1 |
| Akida, JA | 1 |
| Lemnge, MM | 1 |
| Rønn, AM | 1 |
| Theander, TG | 1 |
| Bygbjerg, IC | 1 |
| Kitua, AY | 1 |
| KENNEDY, AF | 1 |
| GLICK, L | 1 |
| DE BLECOURT, JJ | 1 |
| BODE, JJ | 1 |
| NAGELSMIT, WF | 1 |
| PERRY, HO | 1 |
| BARTHOLOMEW, LG | 1 |
| HANLON, DG | 1 |
| Booth, K | 1 |
| Larkin, K | 1 |
| Maddocks, I | 1 |
| Schulthess, HK | 1 |
| von Felten, A | 1 |
| Gmür, J | 1 |
| Neftel, K | 1 |
| Lepeu, G | 1 |
| Codine, P | 1 |
| Janbon, F | 1 |
| Bertrand, A | 1 |
| Vincent, PC | 2 |
| Gillespie, P | 1 |
| Wagner, F | 1 |
| Eich, G | 1 |
| Neftel, KA | 2 |
| Aymard, JP | 2 |
| Rouveix, B | 2 |
| Ferry, R | 1 |
| Janot, C | 1 |
| May, T | 1 |
| Legras, B | 1 |
| Streiff, F | 1 |
| Hatton, CS | 1 |
| Peto, TE | 1 |
| Bunch, C | 1 |
| Pasvol, G | 1 |
| Russell, SJ | 1 |
| Singer, CR | 1 |
| Edwards, G | 1 |
| Winstanley, P | 1 |
| Carr, R | 1 |
| Coulombel, L | 1 |
| Chau, F | 1 |
| Abel, L | 1 |
| Rhodes, EG | 1 |
| Ball, J | 1 |
| Franklin, IM | 1 |
| Woodtly, W | 1 |
| Schmid, M | 1 |
| Frick, PG | 1 |
| Fehr, J | 1 |
| Ellis, ME | 1 |
| Steed, AJ | 1 |
| Addison, GM | 1 |
| Woodtli, W | 1 |
| Vonmoos, P | 1 |
| Siegrist, P | 1 |
| Zollikofer, H | 1 |
| Douer, D | 1 |
| Schwartz, E | 1 |
| Shaked, N | 1 |
| Ramot, B | 1 |
| Lind, DE | 1 |
| Levi, JA | 1 |
1 review available for amodiaquine and Agranulocytosis
| Article | Year |
|---|---|
[Evaluation of hematologic side effects of anti-infective therapy: agranulocytosis caused by beta-lactam antibiotics, vancomycin and amodiaquine].
Topics: Agranulocytosis; Amodiaquine; Animals; Anti-Bacterial Agents; beta-Lactams; Humans; Neutropenia; Van | 1991 |
1 trial available for amodiaquine and Agranulocytosis
| Article | Year |
|---|---|
Biological and haematological safety profile of oral amodiaquine and chloroquine in healthy volunteers with or without Plasmodium falciparum infection in northeast Tanzania.
Topics: Adolescent; Adult; Agranulocytosis; Amodiaquine; Analysis of Variance; Animals; Antimalarials; Chemi | 2008 |
22 other studies available for amodiaquine and Agranulocytosis
| Article | Year |
|---|---|
Involvement of myeloperoxidase and NADPH oxidase in the covalent binding of amodiaquine and clozapine to neutrophils: implications for drug-induced agranulocytosis.
Topics: Agranulocytosis; Amodiaquine; Animals; Clozapine; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked | 2014 |
Exploring an animal model of amodiaquine-induced liver injury in rats and mice.
Topics: Agranulocytosis; Amodiaquine; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cycl | 2016 |
Absolute neutrophil leucopenia after uncontrolled use of amodiaquine.
Topics: Agranulocytosis; Amodiaquine; Antimalarials; Humans; Leukopenia; Neutrophils | 1955 |
Fatal agranulocytosis during treatment with a amodiaquine.
Topics: Agranulocytosis; Amodiaquine; Antimalarials; Humans | 1957 |
[Agranulocytosis after treatment of disseminated lupus erythematosus with amodiaquin (camoquin)].
Topics: Agranulocytosis; Amodiaquine; Antimalarials; Humans; Lupus Erythematosus, Systemic | 1959 |
Nearly fatal reaction to amodiaquine.
Topics: Agranulocytosis; Amodiaquine; Antimalarials; Hepatitis; Humans | 1962 |
Agranulocytosis coincident with amodiaquine therapy.
Topics: Adult; Agranulocytosis; Amodiaquine; Bone Marrow Examination; Female; Humans; Leukocyte Count; Male; | 1967 |
[Amodiaquine-induced agranulocytosis in malaria prevention: demonstration of an amodiaquine-induced cytotoxic antibody against granulocytes].
Topics: Adolescent; Agglutinins; Agranulocytosis; Amodiaquine; Antibody-Dependent Cell Cytotoxicity; Blood T | 1983 |
[Amodiaquine-induced agranulocytosis].
Topics: Adult; Agranulocytosis; Amodiaquine; Humans; Malaria; Male | 1981 |
In vitro study of drug-induced granulocytopenia.
Topics: Agranulocytosis; Amodiaquine; Bone Marrow; Culture Techniques; Female; Humans; Male; Middle Aged; Qu | 1980 |
Amodiaquine agranulocytosis.
Topics: Adult; Agranulocytosis; Amodiaquine; Female; Humans; Neutropenia | 1977 |
Amodiaquine-induced agranulocytosis: report of a case with in vitro studies of granulocyte-macrophage progenitor cells.
Topics: Agranulocytosis; Amodiaquine; Bone Marrow; Cell Division; Colony-Forming Units Assay; Female; Granul | 1989 |
Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria.
Topics: Acute Disease; Adult; Agranulocytosis; Amodiaquine; Drug Combinations; Drug Therapy, Combination; Fe | 1986 |
Neutropenia and prophylactic amodiaquine.
Topics: Adolescent; Aged; Agranulocytosis; Amodiaquine; Humans; Malaria; Male; Middle Aged; Neutropenia | 1986 |
Amodiaquine-induced immune agranulocytosis.
Topics: Agranulocytosis; Amodiaquine; Female; Humans; Immunoglobulin G; Malaria; Male; Middle Aged; Neutroph | 1989 |
Agranulocytosis associated with the use of amodiaquine for malaria prophylaxis.
Topics: Agranulocytosis; Amodiaquine; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; Proguan | 1986 |
Amodiaquine induced agranulocytosis: inhibition of colony growth in bone marrow by antimalarial agents.
Topics: Adult; Agranulocytosis; Amodiaquine; Antimalarials; Bone Marrow; Bone Marrow Cells; Cells, Cultured; | 1986 |
Amodiaquine induced agranulocytosis and liver damage.
Topics: Adolescent; Adult; Aged; Agranulocytosis; Amodiaquine; Chemical and Drug Induced Liver Injury; Femal | 1986 |
Neutropenia associated with dual antimalarial chemoprophylaxis--use of bone-marrow culture as an aid in further drug management.
Topics: Adult; Agranulocytosis; Amodiaquine; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Drug Therapy, | 1987 |
[Amodiaquine-induced hepatitis with leukopenia].
Topics: Adult; Agranulocytosis; Amodiaquine; Chemical and Drug Induced Liver Injury; Diagnosis, Differential | 1986 |
Amodiaquine-induced agranulocytosis: drug inhibition of myeloid colonies in the presence of patient's serum.
Topics: Agranulocytosis; Amodiaquine; Bone Marrow Cells; Colony-Forming Units Assay; Dipyrone; Drug Interact | 1985 |
Amodiaquine-induced agranulocytosis: toxic effect of amodiaquine in bone marrow cultures in vitro.
Topics: Adult; Agranulocytosis; Amodiaquine; Anti-Bacterial Agents; Blood Cells; Bone Marrow; Bone Marrow Ce | 1973 |