amobarbital has been researched along with Parkinson Disease in 9 studies
Amobarbital: A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)
amobarbital : A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by a 3-methylbutyl and an ethyl group at position 5. Amobarbital has been shown to exhibit sedative and hypnotic properties.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Acute administration of tetrabenazine produced tremor in cats, in doses which caused sedation but not hypothermia." | 7.65 | Tremor induced by tetrabenazine. ( Calne, DB; Webster, RA, 1969) |
| " Acute administration of tetrabenazine produced tremor in cats, in doses which caused sedation but not hypothermia." | 3.65 | Tremor induced by tetrabenazine. ( Calne, DB; Webster, RA, 1969) |
| "As a major co-morbidity of Parkinson's disease (PD), depression is associated with the loss of serotonergic neurons." | 1.34 | Rotenone selectively kills serotonergic neurons through a microtubule-dependent mechanism. ( Feng, J; Ren, Y, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (77.78) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| OBRADOR, S | 1 |
| CARRASCOSA, R | 1 |
| CARBONELL, J | 1 |
| ONUAGULUCHI, G | 1 |
| ALEMA, G | 1 |
| ROSADINI, G | 1 |
| ROSSI, GF | 1 |
| Winkler-Stuck, K | 1 |
| Wiedemann, FR | 1 |
| Wallesch, CW | 1 |
| Kunz, WS | 1 |
| Ren, Y | 1 |
| Feng, J | 1 |
| Kalow, W | 1 |
| Austin, G | 1 |
| Hayward, W | 1 |
| Tsai, C | 1 |
| Kuykendall, A | 1 |
| Calne, DB | 1 |
| Webster, RA | 1 |
| Leissner, P | 1 |
| Petersén, I | 1 |
| Sörbye, R | 1 |
1 review available for amobarbital and Parkinson Disease
| Article | Year |
|---|---|
Ethnic differences in reactions to drugs and xenobiotics. Conjugation reactions.
Topics: Acetaminophen; Amobarbital; Asian People; Canada; Catechol O-Methyltransferase; Ethnicity; Female; G | 1986 |
8 other studies available for amobarbital and Parkinson Disease
| Article | Year |
|---|---|
Study of some motor syndromes (rigidity, tremor, spasticity and hemidecortication) by the carotid amytal test.
Topics: Amobarbital; Humans; Movement Disorders; Muscle Rigidity; Muscle Spasticity; Neurology; Parkinson Di | 1961 |
Drug therapy in the crises of postencephalitic parkinsonism.
Topics: Amobarbital; Encephalitis; Encephalitis, Arbovirus; Humans; Parkinson Disease; Parkinson Disease, Po | 1961 |
[Preliminary experiments on the effects of the intracarotid introduction of sodium amytal in parkinsonian syndromes].
Topics: Amobarbital; Parkinson Disease; Parkinsonian Disorders | 1961 |
Effect of coenzyme Q10 on the mitochondrial function of skin fibroblasts from Parkinson patients.
Topics: Adenosine Diphosphate; Adult; Aged; Amobarbital; Antioxidants; Cells, Cultured; Coenzymes; Drug Inte | 2004 |
Rotenone selectively kills serotonergic neurons through a microtubule-dependent mechanism.
Topics: Amobarbital; Animals; Cell Death; Cells, Cultured; Colchicine; Electron Transport Complex I; Mesence | 2007 |
Parkinsonian tremor: soe aspects of an experimental model and its solution.
Topics: Amobarbital; Basal Ganglia; Computers, Analog; Electric Stimulation; Electromyography; Epinephrine; | 1965 |
Tremor induced by tetrabenazine.
Topics: Amobarbital; Animals; Body Temperature; Cats; Disease Models, Animal; Hot Temperature; Parkinson Dis | 1969 |
Chlormethiazole, amobarbital, lidocaine and PLT 101 in spasticity and rigidity: a study of clinical and EMG-Registrable effects on intravenous injection.
Topics: Adolescent; Adult; Aged; Amobarbital; Chlormethiazole; Electromyography; Female; Humans; Hypnotics a | 1969 |