amobarbital has been researched along with Myocardial Ischemia in 5 studies
Amobarbital: A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)
amobarbital : A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by a 3-methylbutyl and an ethyl group at position 5. Amobarbital has been shown to exhibit sedative and hypnotic properties.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amobarbital-treated hearts received drug for 1 min before ischemia." | 1.33 | Blockade of electron transport before cardiac ischemia with the reversible inhibitor amobarbital protects rat heart mitochondria. ( Chen, Q; Hoppel, CL; Lesnefsky, EJ, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, M | 1 |
| Stowe, DF | 2 |
| Udoh, KB | 1 |
| Heisner, JS | 1 |
| Camara, AK | 2 |
| Chen, Q | 3 |
| Yin, G | 1 |
| Stewart, S | 1 |
| Hu, Y | 1 |
| Lesnefsky, EJ | 3 |
| Hoppel, CL | 1 |
| Aldakkak, M | 1 |
| Ambrosio, G | 1 |
| Zweier, JL | 1 |
| Duilio, C | 1 |
| Kuppusamy, P | 1 |
| Santoro, G | 1 |
| Elia, PP | 1 |
| Tritto, I | 1 |
| Cirillo, P | 1 |
| Condorelli, M | 1 |
| Chiariello, M | 1 |
5 other studies available for amobarbital and Myocardial Ischemia
| Article | Year |
|---|---|
Reversible blockade of complex I or inhibition of PKCĪ² reduces activation and mitochondria translocation of p66Shc to preserve cardiac function after ischemia.
Topics: Amobarbital; Animals; Electron Transport; Electron Transport Complex I; Enzyme Activation; Guinea Pi | 2014 |
Isolating the segment of the mitochondrial electron transport chain responsible for mitochondrial damage during cardiac ischemia.
Topics: Amobarbital; Animals; Cytochromes c; Disease Models, Animal; Electron Transport; Electron Transport | 2010 |
Blockade of electron transport before cardiac ischemia with the reversible inhibitor amobarbital protects rat heart mitochondria.
Topics: Amobarbital; Animals; Cardiotonic Agents; Citrate (si)-Synthase; Cytochromes; Dose-Response Relation | 2006 |
Inhibited mitochondrial respiration by amobarbital during cardiac ischaemia improves redox state and reduces matrix Ca2+ overload and ROS release.
Topics: Amobarbital; Animals; Calcium; Electron Transport Complex I; Flavin-Adenine Dinucleotide; Guinea Pig | 2008 |
Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow.
Topics: Adenosine Triphosphate; Amobarbital; Animals; Electron Spin Resonance Spectroscopy; Female; Free Rad | 1993 |