amobarbital has been researched along with Memory Disorders in 51 studies
Amobarbital: A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)
amobarbital : A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by a 3-methylbutyl and an ethyl group at position 5. Amobarbital has been shown to exhibit sedative and hypnotic properties.
Memory Disorders: Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "While the intracarotid amobarbital procedure (IAP) was originally utilized to lateralize speech functions as an aid in the surgical treatment of epilepsy, additional uses for the IAP have emerged including: (1) the use of the IAP to predict post-surgical memory changes, including both global amnesia and smaller, yet significant, material-specific memory deficits; (2) the use of the IAP to provide confirmatory evidence of lateralization of seizure focus; and (3) the use of the IAP to predict post-surgical relief from seizures." | 8.80 | Beyond speech lateralization: a review of the variability, reliability, and validity of the intracarotid amobarbital procedure and its nonlanguage uses in epilepsy surgery candidates. ( Simkins-Bullock, J, 2000) |
| "While the intracarotid amobarbital procedure (IAP) was originally utilized to lateralize speech functions as an aid in the surgical treatment of epilepsy, additional uses for the IAP have emerged including: (1) the use of the IAP to predict post-surgical memory changes, including both global amnesia and smaller, yet significant, material-specific memory deficits; (2) the use of the IAP to provide confirmatory evidence of lateralization of seizure focus; and (3) the use of the IAP to predict post-surgical relief from seizures." | 4.80 | Beyond speech lateralization: a review of the variability, reliability, and validity of the intracarotid amobarbital procedure and its nonlanguage uses in epilepsy surgery candidates. ( Simkins-Bullock, J, 2000) |
| "Differences in Wada memory performance after left and right amobarbital injection are powerful predictors of pre- to postoperative memory change among adult epilepsy patients after anterior temporal lobectomy." | 3.73 | Prediction of verbal memory decline after epilepsy surgery in children: effectiveness of Wada memory asymmetries. ( Blackburn, LB; Lee, GP; Loring, DW; Park, YD; Westerveld, M, 2005) |
| "Amobarbital (80 mg in total) was injected selectively in two sessions in the left and right anterior choroidal artery in six male patients with tinnitus: four with unilateral tinnitus, two with bilateral tinnitus." | 3.73 | Amygdalohippocampal involvement in tinnitus and auditory memory. ( De Ridder, D; Francois, O; Fransen, H; Kovacs, S; Sunaert, S; Van De Heyning, P, 2006) |
| "The aim of this study was to determine whether the predictive value of the intracarotid amobarbital test (IAT) for the side to be resected is applicable only to medial temporal lobe epilepsy and to investigate whether there are different patterns of memory performances on the IAT between patients with unilateral mesial temporal sclerosis (UMT group) and those without (non-UMT group)." | 3.70 | Lateralized memory deficits on the Wada test correlate with the side of lobectomy only for patients with unilateral medial temporal lobe epilepsy. ( Hayashi, K; Kakeuchi, J; Kanemoto, K; Kawasaki, J; Kubo, H; Morimura, T; Takenouchi, K, 1999) |
| "The amobarbital (Amytal) sodium test has been considered an indispensable tool in the presurgical examination of patients for epilepsy surgery." | 3.68 | Memory performance during the Amytal test in patients with non-temporal lobe epilepsy. ( Dasheiff, RM; Ryan, C; Shelton, J, 1993) |
| "Twenty-six patients with medically refractory epilepsy had a seizure focus amenable to selective amygdalohippocampectomy (AHE)." | 1.56 | Selective posterior cerebral artery amobarbital test: a predictor of memory following subtemporal selective amygdalohippocampectomy. ( Albuquerque, FC; Brigeman, S; Catapano, JS; Cavalcanti, DD; Ducruet, AF; Fredrickson, VL; Hlubek, RJ; Labib, MA; Morgan, CD; Smith, KA; Wang, DJ; Whiting, AC, 2020) |
| "Four patients had nominal dysphasia for 1-3 min." | 1.31 | Posterior cerebral artery Wada test: sodium amytal distribution and functional deficits. ( Behrends, K; Biersack, HJ; Klemm, E; Linke, DB; Schild, HH; Schramm, J; Urbach, H, 2001) |
| "Intracarotid injection of a low dosage of amobarbital (75 mg, 5% solution) was studied in 30 temporal lobectomy candidates while naming achromatic, incongruously, and congruously colored pictorial objects and reading real, nonsense, and embedded words." | 1.30 | Semantic, phonological, and perceptual changes following left and right intracarotid injection (Wada) with a low amytal dosage. ( August, A; Fedio, P; Kufta, C; Patronas, N; Sato, S, 1997) |
| "In all conditions, no relationship to seizure focus was observed." | 1.28 | The intracarotid amobarbital sodium procedure. False-positive errors during recognition memory assessment. ( Lee, GP; Loring, DW; Meador, KJ, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (17.65) | 18.7374 |
| 1990's | 19 (37.25) | 18.2507 |
| 2000's | 18 (35.29) | 29.6817 |
| 2010's | 3 (5.88) | 24.3611 |
| 2020's | 2 (3.92) | 2.80 |
| Authors | Studies |
|---|---|
| Kaestner, E | 1 |
| Pedersen, NP | 1 |
| Hu, R | 1 |
| Vosoughi, A | 1 |
| Alwaki, A | 1 |
| Ruiz, AR | 1 |
| Staikova, E | 1 |
| Hewitt, KC | 1 |
| Epstein, C | 1 |
| McDonald, CR | 1 |
| Gross, RE | 1 |
| Drane, DL | 1 |
| Schmid, E | 1 |
| Thomschewski, A | 1 |
| Taylor, A | 1 |
| Zimmermann, G | 1 |
| Kirschner, M | 1 |
| Kobulashvili, T | 1 |
| Brigo, F | 1 |
| Rados, M | 1 |
| Helmstaedter, C | 1 |
| Braun, K | 1 |
| Trinka, E | 1 |
| Catapano, JS | 1 |
| Whiting, AC | 1 |
| Wang, DJ | 1 |
| Hlubek, RJ | 1 |
| Labib, MA | 1 |
| Morgan, CD | 1 |
| Brigeman, S | 1 |
| Fredrickson, VL | 1 |
| Cavalcanti, DD | 1 |
| Smith, KA | 1 |
| Ducruet, AF | 1 |
| Albuquerque, FC | 1 |
| Busch, RM | 1 |
| Chapin, JS | 1 |
| Umashankar, G | 1 |
| Diehl, B | 1 |
| Harvey, D | 1 |
| Naugle, RI | 2 |
| Nair, D | 1 |
| Najm, IM | 1 |
| Zijlmans, M | 1 |
| Huibers, CJ | 1 |
| Huiskamp, GJ | 1 |
| de Kort, GA | 1 |
| Alpherts, WC | 1 |
| Leijten, FS | 1 |
| Hendrikse, J | 1 |
| Carvajal-Castrillón, J | 1 |
| Zapata, J | 1 |
| Galeano-Toro, LM | 1 |
| Bareño, J | 1 |
| Jiménez, M | 1 |
| Stroup, E | 1 |
| Langfitt, J | 1 |
| Berg, M | 1 |
| McDermott, M | 1 |
| Pilcher, W | 1 |
| Como, P | 1 |
| CAIRD, WK | 1 |
| LAVERTY, SG | 1 |
| INGLIS, J | 1 |
| Loring, DW | 5 |
| Meador, KJ | 4 |
| Lee, GP | 5 |
| Smith, JR | 3 |
| Westerveld, M | 2 |
| Blackburn, LB | 1 |
| Park, YD | 1 |
| Bookheimer, S | 1 |
| Schrader, LM | 1 |
| Rausch, R | 1 |
| Sankar, R | 1 |
| Engel, J | 1 |
| Kirsch, HE | 1 |
| Walker, JA | 1 |
| Winstanley, FS | 1 |
| Hendrickson, R | 1 |
| Wong, ST | 1 |
| Barbaro, NM | 1 |
| Laxer, KD | 1 |
| Garcia, PA | 1 |
| Cheung, MC | 1 |
| Chan, AS | 1 |
| Chan, YL | 1 |
| Lam, JM | 1 |
| Lam, W | 1 |
| Pauli, E | 1 |
| Hildebrandt, M | 1 |
| Romstöck, J | 1 |
| Stefan, H | 1 |
| Blümcke, I | 1 |
| De Ridder, D | 1 |
| Fransen, H | 1 |
| Francois, O | 1 |
| Sunaert, S | 1 |
| Kovacs, S | 1 |
| Van De Heyning, P | 1 |
| Baxendale, S | 1 |
| Thompson, P | 1 |
| Harkness, W | 1 |
| Duncan, J | 1 |
| Kanner, AM | 1 |
| Kneebone, AC | 1 |
| Chelune, GJ | 1 |
| Dinner, DS | 1 |
| Awad, IA | 1 |
| King, DW | 2 |
| Gallagher, BB | 2 |
| Murro, AM | 2 |
| Dasheiff, RM | 1 |
| Shelton, J | 1 |
| Ryan, C | 1 |
| Hart, J | 1 |
| Lewis, PJ | 1 |
| Lesser, RP | 1 |
| Fisher, RS | 1 |
| Monsein, LH | 1 |
| Schwerdt, P | 1 |
| Bandeen-Roche, K | 1 |
| Gordon, B | 1 |
| Gratton, CA | 1 |
| Nichols, ME | 1 |
| Perrine, K | 2 |
| Gershengorn, J | 2 |
| Brown, ER | 1 |
| Choi, IS | 1 |
| Luciano, DJ | 2 |
| Devinsky, O | 2 |
| Caner-Cukiert, AR | 1 |
| Cukiert, A | 1 |
| Gronich, G | 1 |
| Marino Júnior, R | 1 |
| Carpenter, K | 1 |
| Oxbury, JM | 1 |
| Oxbury, S | 1 |
| Wright, GD | 1 |
| Morton, N | 1 |
| Polkey, CE | 1 |
| Cox, T | 1 |
| Morris, RG | 1 |
| Jones-Gotman, M | 1 |
| Rouleau, I | 2 |
| Snyder, PJ | 1 |
| Milner, B | 3 |
| Wieser, HG | 1 |
| Müller, S | 1 |
| Schiess, R | 1 |
| Khan, N | 1 |
| Regard, M | 1 |
| Landis, T | 1 |
| Bjeljac, M | 1 |
| Buck, A | 1 |
| Valavanis, A | 1 |
| Yasargil, G | 1 |
| Yonekawa, Y | 1 |
| Fedio, P | 2 |
| August, A | 1 |
| Patronas, N | 1 |
| Sato, S | 1 |
| Kufta, C | 1 |
| Dodrill, CB | 1 |
| Ojemann, GA | 1 |
| Robidoux, J | 1 |
| Labrecque, R | 1 |
| Denault, C | 1 |
| Donofrio, N | 1 |
| Nelson, PK | 1 |
| Kanemoto, K | 1 |
| Kawasaki, J | 1 |
| Takenouchi, K | 1 |
| Hayashi, K | 1 |
| Kubo, H | 1 |
| Morimura, T | 1 |
| Kakeuchi, J | 1 |
| Simkins-Bullock, J | 1 |
| McCabe, PH | 1 |
| Eslinger, PJ | 1 |
| Bell, BD | 1 |
| Davies, KG | 1 |
| Haltiner, AM | 1 |
| Walters, GL | 1 |
| Kubu, CS | 1 |
| Girvin, JP | 1 |
| McLachlan, RS | 1 |
| Pavol, M | 1 |
| Harnadek, MC | 1 |
| Urbach, H | 1 |
| Klemm, E | 1 |
| Linke, DB | 1 |
| Behrends, K | 1 |
| Biersack, HJ | 1 |
| Schramm, J | 1 |
| Schild, HH | 1 |
| Chiaravalloti, ND | 1 |
| Glosser, G | 1 |
| Sabsevitz, DS | 1 |
| Swanson, SJ | 1 |
| Morris, GL | 1 |
| Mueller, WM | 1 |
| Seidenberg, M | 1 |
| Sass, KJ | 1 |
| Lencz, T | 1 |
| Novelly, RA | 1 |
| Spencer, DD | 1 |
| Kim, JH | 1 |
| Hietala, SO | 1 |
| Silfvenius, H | 1 |
| Aasly, J | 1 |
| Olivecrona, M | 1 |
| Jonsson, L | 1 |
| Jack, CR | 2 |
| Nichols, DA | 2 |
| Sharbrough, FW | 2 |
| Marsh, WR | 2 |
| Petersen, RC | 2 |
| Hinkeldey, NS | 1 |
| Ivnik, RJ | 1 |
| Cascino, GD | 1 |
| Ilstrup, DM | 1 |
| Miller, DL | 1 |
| Klove, H | 1 |
| Trites, RL | 1 |
| Grabow, JD | 1 |
| Mann, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Does Memantine Improve Verbal Memory Task Performance in Subjects With Localization-related Epilepsy and Memory Dysfunction? A Randomized, Double-Blind, Placebo-Controlled Trial[NCT01054599] | 29 participants (Actual) | Interventional | 2009-01-31 | Completed | |||
| Cognitive Effects of Treatment of Interictal Discharges[NCT00916149] | 31 participants (Actual) | Interventional | 2007-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
SRT-CLTR (range 0-72; higher scores indicate better memory), and 7-24 Spatial Memory Test (range 0-35; scores are summed across the 5 learning trials, with higher scores indicating better memory) scores will be assessed across the first (baseline) and third (post-open label memantine) testing sessions. These measures are considered to be scores on a scale, rather than standard units. The hypothesis was that subjects randomized to memantine would demonstrate sustained improvement from baseline, while the placebo group would demonstrate improvements after taking open label memantine (compared to baseline). (NCT01054599)
Timeframe: 26 weeks
| Intervention | scores on a scale (Mean) | |||
|---|---|---|---|---|
| SRT CLTR Baseline | SRT CLTR Post-Open Label | 7-24 Total Learning Baseline | 7-24 Total Learning Post-Open Label | |
| Memantine | 32.67 | 40.33 | 30.33 | 31.67 |
| Sugar Pill | 22.71 | 40.29 | 28.14 | 32.43 |
Change scores from pre- to post-treatment/placebo were calculated for the primary outcome measures, the Selective Reminding Test Continuous Long-Term Retrieval (range 0-72; higher scores indicate better memory) and 7-24 Spatial Recall Test Total Learning (range 0-35; total correct across 5 learning trials are summed, with higher scores indicating better memory) scores. These measures are scores on a scale, rather than representing standard units. (NCT01054599)
Timeframe: 13 weeks
| Intervention | scores on a scale (Mean) | |
|---|---|---|
| 7-24 Spatial Recall Tests Learning Change Score | SRT Continuous Long-Term Retrieval Change Score | |
| Memantine | 1.00 | 4.38 |
| Sugar Pill | 1.78 | 8.11 |
This descriptive analysis examined the change in interictal discharge rates pre to post-treatment with levetiracetam in subjects with epilepsy and with no treatment in healthy controls. (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | IEDs/hour (Mean) |
|---|---|
| No Treatment | -28.8 |
| Levetiracetam | .54 |
Change in Adverse Events Profile score (scores range from 19-76; higher scores indicate greater side effects) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | scores on a scale (Mean) |
|---|---|
| No Treatment | -1.27 |
| Levetiracetam | 1 |
Change in Brief Visuospatial Memory Test-Revised (BVMT-R) Delayed Recall score (the score ranges from 0-6, reflecting the number of shapes recalled after a 25 minute delay) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | number recalled (Mean) |
|---|---|
| No Treatment | .36 |
| Levetiracetam | .33 |
Change in Brief Visuospatial Memory Test-Revised (BVMT-R) Learning score (the score ranges from 0-6, reflecting the number of shapes recalled on the initial learning trial) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | number recalled (Mean) |
|---|---|
| No Treatment | .45 |
| Levetiracetam | .33 |
Change in Brief Visuospatial Memory Test-Revised (BVMT-R) Total Learning score (the score is summed across 3 learning trials, score range 0-18, reflecting the total number of shapes recalled) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | number recalled (Mean) |
|---|---|
| No Treatment | 1.09 |
| Levetiracetam | .17 |
Change in Choice Accuracy Score (indicate if red or blue stimulus; accuracy 0-100%) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | percentage of correct responses (Mean) |
|---|---|
| No Treatment | .02 |
| Levetiracetam | .1 |
Change in Choice Reaction Time Score, with reaction time measured in seconds (indicate if red or blue stimulus; lower reaction time suggests better performance) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | seconds (Mean) |
|---|---|
| No Treatment | 34.96 |
| Levetiracetam | .45 |
Change in Continuous Performance Test Score - Accuracy (CPT; score ranges from 0-100% correct) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | percentage of correct responses (Mean) |
|---|---|
| No Treatment | -0.01 |
| Levetiracetam | .01 |
Change in Continuous Performance Test Score - Reaction Time, measured in seconds (CPT RT; less time reflects better performance) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | seconds (Mean) |
|---|---|
| No Treatment | 1.04 |
| Levetiracetam | -11.33 |
Change in California Verbal Learning Test (CVLT) Long Delay Recall score (the score ranges from 0-16, reflecting the number of words recalled) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | number recalled (Mean) |
|---|---|
| No Treatment | 1.55 |
| Levetiracetam | 2.67 |
Change in California Verbal Learning Test (CVLT) Short Delay Recall Score (the score ranges from 0-16, reflecting the number of words recalled) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | number recalled (Mean) |
|---|---|
| No Treatment | 1.27 |
| Levetiracetam | -0.4 |
Change in California Verbal Learning Test (CVLT) Total Learning Score (the total learning score is summed across 5 learning trials, range 0-80). Higher scores indicate better memory. Scores on the CVLT reflect the number of words recalled. (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | number recalled (Mean) |
|---|---|
| No Treatment | 8.09 |
| Levetiracetam | 5.5 |
Change in California Verbal Learning Test (CVLT) Trial 1 learning score (range 0-16; higher score indicates better memory) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | scores on a scale (Mean) |
|---|---|
| No Treatment | 2.45 |
| Levetiracetam | 2.5 |
Change in Design Fluency score (Score range: lowest score = 0; there is no upper limit. A higher score reflects more designs generated, hence better performance.) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | scores on a scale (Mean) |
|---|---|
| No Treatment | 2.8 |
| Levetiracetam | .83 |
Change in Digit Span score (score ranges from 0-30; higher scores indicate better performance). Scores indicate the number of digit sequences correctly recalled, forwards and backwards. (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | number recalled (Mean) |
|---|---|
| No Treatment | .73 |
| Levetiracetam | -.33 |
Change in Digit Symbol Score (The score is the number of items completed. A higher score reflects better performance.) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | scores on a scale (Mean) |
|---|---|
| No Treatment | 3.2 |
| Levetiracetam | 1.5 |
Change in Facial Recognition Accuracy Score (accuracy ranges from 0-100%) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | percentage of correct responses (Mean) |
|---|---|
| No Treatment | .01 |
| Levetiracetam | .03 |
Change in Facial Recognition Reaction Time Score (indicates processing speed, with reaction time measured in seconds) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | seconds (Mean) |
|---|---|
| No Treatment | -66.76 |
| Levetiracetam | .61 |
Change in Grooved Pegboard Score (The score is the time for completion. A lower score reflects better performance.) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | seconds (Mean) |
|---|---|
| No Treatment | -4.73 |
| Levetiracetam | -4.36 |
Change in Letter-Number Sequencing score (LNS; score ranges from 0-21; higher scores indicate better performance). The score reflects the number of items that the subject can correctly recall and place in proper alphabetical and numerical sequence. (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | scores on a scale (Mean) |
|---|---|
| No Treatment | .18 |
| Levetiracetam | -0.5 |
Change in Neurological Disorders Depression Inventory for Epilepsy (NDDIE) score (scores range from 0-24; higher scores indicate greater depressive symptoms) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | scores on a scale (Mean) |
|---|---|
| No Treatment | 0.18 |
| Levetiracetam | 1.5 |
Change in Non-verbal Working Memory Accuracy Score (accuracy ranges from 0-100%) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | percentage of correct responses (Mean) |
|---|---|
| No Treatment | -.01 |
| Levetiracetam | 0 |
Change in Non-verbal Working Memory Reaction Time Score (indicates processing speed, with reaction time measured in seconds) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | seconds (Mean) |
|---|---|
| No Treatment | -31.99 |
| Levetiracetam | -25.54 |
Change in Quality of Life Inventory in Epilepsy-89 score (QOLIE; score ranges from 0-100; higher scores reflect better quality of life) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | scores on a scale (Mean) |
|---|---|
| Levetiracetam | 19.6 |
Change in Spatial Span score (score ranges from 0-32; higher scores indicate better performance). Scores indicate the number of spatial sequences correctly recalled, forwards and backwards. (NCT00916149)
Timeframe: 1 and 11 Weeks
| Intervention | number recalled (Mean) |
|---|---|
| No Treatment | .36 |
| Levetiracetam | -1.67 |
Change in Stroop score (The score is the time for completion in seconds; less time reflects better performance.) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | seconds (Mean) |
|---|---|
| No Treatment | .98 |
| Levetiracetam | -7.3 |
Change in Trails Test score (The score is the time for completion in seconds. A lower score reflects better performance.) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | seconds (Mean) |
|---|---|
| No Treatment | -9.51 |
| Levetiracetam | 11.29 |
Change in Verbal Fluency score (Score range: lowest score = 0, with no upper limit, reflecting total number of words generated. Higher scores indicate better performance.) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | scores on a scale (Mean) |
|---|---|
| No Treatment | -1.55 |
| Levetiracetam | -.83 |
Change in Verbal Recognition Accuracy Score (accuracy ranges from 0-100%) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | percentage of correct responses (Mean) |
|---|---|
| No Treatment | .02 |
| Levetiracetam | .14 |
Change in Verbal Recognition Reaction Time Score (indicates processing speed, with reaction time measured in seconds) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | seconds (Mean) |
|---|---|
| No Treatment | 2.98 |
| Levetiracetam | -6.1 |
Change in Verbal Working Memory Accuracy Score (range 0-100%) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | percentage of correct responses (Mean) |
|---|---|
| No Treatment | 0 |
| Levetiracetam | -.02 |
Change in Verbal Working Memory Reaction Time Score, with reaction time measured in seconds (indicates processing speed) (NCT00916149)
Timeframe: 1 and 11 weeks
| Intervention | seconds (Mean) |
|---|---|
| No Treatment | -54.76 |
| Levetiracetam | -9.36 |
3 reviews available for amobarbital and Memory Disorders
| Article | Year |
|---|---|
Diagnostic accuracy of functional magnetic resonance imaging, Wada test, magnetoencephalography, and functional transcranial Doppler sonography for memory and language outcome after epilepsy surgery: A systematic review.
Topics: Amobarbital; Epilepsy; Humans; Language Disorders; Language Tests; Magnetic Resonance Imaging; Magne | 2018 |
Clinical and research contributions of the intracarotid amobarbital procedure to neuropsychology.
Topics: Amobarbital; Brain; Carotid Arteries; Functional Laterality; Humans; Memory Disorders; Neuropsycholo | 1997 |
Beyond speech lateralization: a review of the variability, reliability, and validity of the intracarotid amobarbital procedure and its nonlanguage uses in epilepsy surgery candidates.
Topics: Amobarbital; Brain; Epilepsy; Functional Laterality; Humans; Hypnotics and Sedatives; Injections, In | 2000 |
1 trial available for amobarbital and Memory Disorders
| Article | Year |
|---|---|
Results from the intracarotid amytal procedure in patients with uni or bitemporal lobe epilepsy and mesial sclerosis.
Topics: Amobarbital; Animals; Carotid Artery, Internal; Electroencephalography; Epilepsy, Temporal Lobe; Fun | 1995 |
47 other studies available for amobarbital and Memory Disorders
| Article | Year |
|---|---|
Electrical Wada for pre-surgical memory testing: a case report.
Topics: Amobarbital; Epilepsy, Temporal Lobe; Female; Functional Laterality; Humans; Memory; Memory Disorder | 2022 |
Selective posterior cerebral artery amobarbital test: a predictor of memory following subtemporal selective amygdalohippocampectomy.
Topics: Adult; Amobarbital; Amygdala; Drug Resistant Epilepsy; Female; Hippocampus; Humans; Hypnotics and Se | 2020 |
Poor presurgical performance on both verbal and visual memory measures is associated with low risk for memory decline following left temporal lobectomy for intractable epilepsy.
Topics: Adolescent; Adult; Age of Onset; Amobarbital; Anterior Temporal Lobectomy; Carotid Artery, Common; E | 2008 |
The contribution of posterior circulation to memory function during the intracarotid amobarbital procedure.
Topics: Adolescent; Adult; Amobarbital; Carotid Artery, Internal; Cerebral Angiography; Cerebrovascular Circ | 2012 |
[Changes in verbal and nonverbal memory associated with bilateral hippocampal electrode implantation for epilepsy surgery].
Topics: Adult; Aged; Amobarbital; Anterior Temporal Lobectomy; Carotid Artery, Internal; Dominance, Cerebral | 2012 |
Predicting verbal memory decline following anterior temporal lobectomy (ATL).
Topics: Adult; Amobarbital; Anterior Temporal Lobectomy; Carotid Artery, Internal; Dominance, Cerebral; Epil | 2003 |
Predicting verbal memory decline following anterior temporal lobectomy (ATL).
Topics: Adult; Amobarbital; Anterior Temporal Lobectomy; Carotid Artery, Internal; Dominance, Cerebral; Epil | 2003 |
Predicting verbal memory decline following anterior temporal lobectomy (ATL).
Topics: Adult; Amobarbital; Anterior Temporal Lobectomy; Carotid Artery, Internal; Dominance, Cerebral; Epil | 2003 |
Predicting verbal memory decline following anterior temporal lobectomy (ATL).
Topics: Adult; Amobarbital; Anterior Temporal Lobectomy; Carotid Artery, Internal; Dominance, Cerebral; Epil | 2003 |
Sedation and sleep thresholds in elderly patients with memory disorder.
Topics: Amobarbital; Geriatrics; Memory; Memory Disorders; Mental Disorders; Psychological Tests; Sleep | 1963 |
Structural versus functional prediction of memory change following anterior temporal lobectomy.
Topics: Adult; Amobarbital; Anterior Temporal Lobectomy; Dominance, Cerebral; Epilepsy, Temporal Lobe; Follo | 2004 |
Prediction of verbal memory decline after epilepsy surgery in children: effectiveness of Wada memory asymmetries.
Topics: Adolescent; Amobarbital; Cerebral Cortex; Child; Child, Preschool; Epilepsy; Female; Functional Late | 2005 |
Reduced anesthetization during the intracarotid amobarbital (Wada) test in patients taking carbonic anhydrase-inhibiting medications.
Topics: Amobarbital; Anesthesia; Anterior Temporal Lobectomy; Anticonvulsants; Carbonic Anhydrase Inhibitors | 2005 |
Limitations of Wada memory asymmetry as a predictor of outcomes after temporal lobectomy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amobarbital; Brain; Epilepsy, Temporal Lobe; Functional | 2005 |
Effects of illness duration on memory processing of patients with temporal lobe epilepsy.
Topics: Adolescent; Adult; Amobarbital; Aphasia; Brain Mapping; Cerebral Cortex; Epilepsy, Temporal Lobe; Fe | 2006 |
Deficient memory acquisition in temporal lobe epilepsy is predicted by hippocampal granule cell loss.
Topics: Adult; Amobarbital; Carotid Arteries; Cell Count; Dentate Gyrus; Epilepsy, Temporal Lobe; Female; Hi | 2006 |
Amygdalohippocampal involvement in tinnitus and auditory memory.
Topics: Adult; Aged; Amobarbital; Amygdala; Auditory Perception; Cerebral Angiography; Cerebral Arteries; Ce | 2006 |
The role of the intracarotid amobarbital procedure in predicting verbal memory decline after temporal lobe resection.
Topics: Adolescent; Adult; Age Factors; Amobarbital; Anterior Temporal Lobectomy; Carotid Artery, Internal; | 2007 |
Can fMRI replace the Wada test in predicting postsurgical deterioration of verbal memory?
Topics: Amobarbital; Diagnostic Techniques, Neurological; Epilepsy; Humans; Magnetic Resonance Imaging; Memo | 2008 |
Intracarotid amobarbital procedure as a predictor of material-specific memory change after anterior temporal lobectomy.
Topics: Adolescent; Adult; Amobarbital; Analysis of Variance; Carotid Artery, Internal; Epilepsy; Epilepsy, | 1995 |
Stimulus timing effects on Wada memory testing.
Topics: Adult; Amobarbital; Epilepsy; Functional Laterality; Humans; Memory Disorders; Neuropsychological Te | 1994 |
Memory performance during the Amytal test in patients with non-temporal lobe epilepsy.
Topics: Adolescent; Adult; Amobarbital; Cerebral Cortex; Child; Epilepsy; Female; Humans; Male; Memory Disor | 1993 |
Anatomic correlates of memory from intracarotid amobarbital injections with technetium Tc 99m hexamethylpropyleneamine oxime SPECT.
Topics: Adolescent; Adult; Amobarbital; Brain; Carotid Arteries; Cerebrovascular Circulation; Epilepsy; Fema | 1993 |
Wada memory testing and hippocampal volume measurements in the evaluation for temporal lobectomy.
Topics: Adult; Amobarbital; Epilepsy, Complex Partial; Female; Functional Laterality; Hippocampus; Humans; M | 1993 |
Material-specific memory in the intracarotid amobarbital procedure.
Topics: Amobarbital; Discriminant Analysis; Dominance, Cerebral; Epilepsies, Partial; Epilepsy, Temporal Lob | 1993 |
Memory for objects presented early after intracarotid sodium amytal: a sensitive clinical neuropsychological indicator of temporal lobe pathology.
Topics: Adolescent; Adult; Amobarbital; Female; Functional Laterality; Hippocampus; Humans; Male; Memory Dis | 1996 |
Episodic memory dysfunction during sodium amytal testing of epileptic patients in relation to posterior cerebral artery perfusion.
Topics: Adult; Amobarbital; Cerebral Arteries; Cerebrovascular Circulation; Epilepsy, Temporal Lobe; Female; | 1996 |
Amobarbital memory testing: some personal reflections.
Topics: Amobarbital; Aphasia; Brain; Carotid Arteries; Hippocampus; Humans; Injections, Intra-Arterial; Memo | 1997 |
The anterior and posterior selective temporal lobe amobarbital tests: angiographic, clinical, electroencephalographic, PET, SPECT findings, and memory performance.
Topics: Adult; Amobarbital; Carotid Artery, Internal; Cerebral Angiography; Electroencephalography; Female; | 1997 |
Semantic, phonological, and perceptual changes following left and right intracarotid injection (Wada) with a low amytal dosage.
Topics: Adult; Amobarbital; Carotid Artery, Internal; Female; Functional Laterality; Humans; Injections, Int | 1997 |
An exploratory comparison of three methods of memory assessment with the intracarotid amobarbital procedure.
Topics: Adult; Amobarbital; Cerebral Decortication; Dominance, Cerebral; Epilepsy, Temporal Lobe; Female; Fo | 1997 |
Effect of focus lateralization on memory assessment during the intracarotid amobarbital procedure.
Topics: Amobarbital; Analysis of Variance; Cross-Sectional Studies; Dominance, Cerebral; Epilepsy, Temporal | 1997 |
Interhemispheric memory transfer in the intracarotid amobarbital procedure.
Topics: Adult; Amobarbital; Carotid Artery, Internal; Cerebral Cortex; Dominance, Cerebral; Epilepsy, Tempor | 1998 |
Lateralized memory deficits on the Wada test correlate with the side of lobectomy only for patients with unilateral medial temporal lobe epilepsy.
Topics: Adult; Amobarbital; Electroencephalography; Epilepsy, Temporal Lobe; Female; Functional Laterality; | 1999 |
Abnormal Wada and neuropsychological testing results due to topiramate therapy.
Topics: Amobarbital; Anticonvulsants; Carbamazepine; Carotid Artery, Internal; Drug Therapy, Combination; Ep | 2000 |
Intracarotid amobarbital procedure and prediction of postoperative memory in patients with left temporal lobe epilepsy and hippocampal sclerosis.
Topics: Adult; Amobarbital; Brain Diseases; Carotid Artery, Internal; Epilepsy, Temporal Lobe; Female; Hippo | 2000 |
Does the intracarotid amobarbital procedure predict global amnesia after temporal lobectomy?
Topics: Adult; Amobarbital; Carotid Artery, Internal; Comorbidity; Epilepsy, Temporal Lobe; Follow-Up Studie | 2000 |
Posterior cerebral artery Wada test: sodium amytal distribution and functional deficits.
Topics: Adult; Amobarbital; Aphasia; Brain; Epilepsy, Temporal Lobe; Female; Hemianopsia; Humans; Injections | 2001 |
Material-specific memory changes after anterior temporal lobectomy as predicted by the intracarotid amobarbital test.
Topics: Adult; Amobarbital; Carotid Artery, Internal; Epilepsies, Partial; Epilepsy, Temporal Lobe; Function | 2001 |
Memory outcome after left anterior temporal lobectomy in patients with expected and reversed Wada memory asymmetry scores.
Topics: Adult; Amobarbital; Epilepsy, Temporal Lobe; Functional Laterality; Humans; Memory; Memory Disorders | 2001 |
Psychological aspects of focal epilepsy and its neurosurgical management.
Topics: Adolescent; Adult; Amobarbital; Auditory Perception; Child; Child, Preschool; Cognition; Epilepsies, | 1975 |
The neural substrate of memory impairment demonstrated by the intracarotid amobarbital procedure.
Topics: Adolescent; Adult; Amobarbital; Hippocampus; Humans; Injections, Intra-Arterial; Memory; Memory Diso | 1991 |
Brain perfusion with intracarotid injection of 99mTc-HM-PAO in partial epilepsy during amobarbital testing.
Topics: Adult; Amobarbital; Brain; Carotid Artery, Internal; Cerebral Angiography; Cerebrovascular Circulati | 1990 |
Selective posterior cerebral artery injection of amytal: new method of preoperative memory testing.
Topics: Adolescent; Adult; Amobarbital; Carotid Artery, Internal; Cerebral Angiography; Cerebral Arteries; E | 1989 |
The intracarotid amobarbital sodium procedure. False-positive errors during recognition memory assessment.
Topics: Adult; Amobarbital; Carotid Arteries; Diagnostic Errors; Dominance, Cerebral; Female; Humans; Inject | 1989 |
Selective posterior cerebral artery Amytal test for evaluating memory function before surgery for temporal lobe seizure.
Topics: Adolescent; Adult; Amobarbital; Carotid Artery, Internal; Cerebral Angiography; Cerebral Arteries; D | 1988 |
Whither the Wada?
Topics: Amobarbital; Carotid Artery, Internal; Dominance, Cerebral; Epilepsy, Temporal Lobe; Humans; Memory | 1988 |
Intracarotid sodium amytal for evaluating memory function.
Topics: Amobarbital; Functional Laterality; Humans; Memory Disorders; Postoperative Complications; Temporal | 1970 |
Disorders of learning and memory after temporal lobe lesions in man.
Topics: Adult; Amnesia; Amobarbital; Brain Diseases; Epilepsy, Temporal Lobe; Hippocampus; Humans; Learning | 1972 |
The use of sodium amobarbital in psychiatry.
Topics: Adult; Amobarbital; Depression; Humans; Hysteria; Interview, Psychological; Male; Memory Disorders; | 1969 |