amobarbital has been researched along with Injury, Myocardial Reperfusion in 8 studies
Amobarbital: A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)
amobarbital : A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by a 3-methylbutyl and an ethyl group at position 5. Amobarbital has been shown to exhibit sedative and hypnotic properties.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amobarbital treatment decreased cardiac injury and protected respiration." | 1.48 | Intermediary metabolism and fatty acid oxidation: novel targets of electron transport chain-driven injury during ischemia and reperfusion. ( Chen, Q; Hollander, JM; Hu, Y; Lesnefsky, EJ; Thompson, J; Younus, M, 2018) |
| "Amobarbital (2." | 1.38 | Postconditioning modulates ischemia-damaged mitochondria during reperfusion. ( Chen, Q; Gomez, L; Hu, Y; Lesnefsky, EJ; Li, H; Paillard, M, 2012) |
| "Amobarbital-treated hearts received drug for 1 min before ischemia." | 1.33 | Blockade of electron transport before cardiac ischemia with the reversible inhibitor amobarbital protects rat heart mitochondria. ( Chen, Q; Hoppel, CL; Lesnefsky, EJ, 2006) |
| "Amobarbital treatment immediately before ischemia was used to test the hypothesis that damage to mitochondrial respiration occurs mainly during ischemia and that protection of mitochondria during ischemia leads to decreased cardiac injury with reperfusion." | 1.33 | Reversible blockade of electron transport during ischemia protects mitochondria and decreases myocardial injury following reperfusion. ( Chen, Q; Hoppel, CL; Lesnefsky, EJ; Moghaddas, S, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Akande, O | 1 |
| Chen, Q | 7 |
| Cholyway, R | 1 |
| Toldo, S | 1 |
| Lesnefsky, EJ | 7 |
| Quader, M | 1 |
| Younus, M | 1 |
| Thompson, J | 1 |
| Hu, Y | 2 |
| Hollander, JM | 1 |
| Stewart, S | 1 |
| Paillard, M | 1 |
| Gomez, L | 1 |
| Li, H | 1 |
| Hoppel, CL | 2 |
| Moghaddas, S | 1 |
| Park, JW | 1 |
| Chun, YS | 1 |
| Kim, YH | 1 |
| Kim, CH | 1 |
| Kim, MS | 1 |
8 other studies available for amobarbital and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Modulation of Mitochondrial Respiration During Early Reperfusion Reduces Cardiac Injury in Donation After Circulatory Death Hearts.
Topics: Amobarbital; Animals; Electron Transport; Heart Transplantation; Humans; Infarction; Mitochondria, H | 2022 |
Intermediary metabolism and fatty acid oxidation: novel targets of electron transport chain-driven injury during ischemia and reperfusion.
Topics: Amobarbital; Animals; Disease Models, Animal; Electron Transport Chain Complex Proteins; Energy Meta | 2018 |
Reversible blockade of electron transport with amobarbital at the onset of reperfusion attenuates cardiac injury.
Topics: Amobarbital; Animals; Electron Transport; Heart Injuries; Hydrogen Peroxide; Male; Myocardial Reperf | 2009 |
Blockade of electron transport during ischemia preserves bcl-2 and inhibits opening of the mitochondrial permeability transition pore.
Topics: Amobarbital; Animals; Benzopyrans; Cytochromes c; Electron Transport; Hydrogen Peroxide; Immunoblott | 2011 |
Postconditioning modulates ischemia-damaged mitochondria during reperfusion.
Topics: Amobarbital; Animals; Electron Transport; In Vitro Techniques; Ischemic Postconditioning; Male; Memb | 2012 |
Blockade of electron transport before cardiac ischemia with the reversible inhibitor amobarbital protects rat heart mitochondria.
Topics: Amobarbital; Animals; Cardiotonic Agents; Citrate (si)-Synthase; Cytochromes; Dose-Response Relation | 2006 |
Reversible blockade of electron transport during ischemia protects mitochondria and decreases myocardial injury following reperfusion.
Topics: Amobarbital; Animals; Citrate (si)-Synthase; Cytochromes; Cytochromes c; Electron Transport; Hydroge | 2006 |
Ischemic preconditioning reduces Op6 generation and prevents respiratory impairment in the mitochondria of post-ischemic reperfused heart of rat.
Topics: Amobarbital; Animals; Antioxidants; Cell Hypoxia; Free Radicals; Ischemic Preconditioning, Myocardia | 1997 |