amobarbital has been researched along with Hypoxia in 21 studies
Amobarbital: A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)
amobarbital : A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by a 3-methylbutyl and an ethyl group at position 5. Amobarbital has been shown to exhibit sedative and hypnotic properties.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Population spike amplitude (PSAP) and NADH were measured during hypoxic hypoxia (15 min) and recovery (45 min)." | 3.72 | Graded reoxygenation with chemical inhibition of oxidative phosphorylation improves posthypoxic recovery in murine hippocampal slices. ( Büchner, M; Huber, R; Riepe, MW; Spiegel, T, 2004) |
| "88 mM Amytal (amobarbital), hypoxia (95% N2-5% CO2), or 12 microM adenosine in the presence and absence of 2." | 3.67 | Relationship of myocardial metabolism and coronary flow: dependence on extracellular calcium. ( Erecińska, M; Rumsey, WL; Wilson, DF, 1987) |
| "In conclusion, our results suggest that neither the redox state of cytochrome oxidase nor adenosine are critical factors in the regulation of cerebral blood flow during arterial hypoxia and epileptic seizures." | 3.67 | Regulation of cerebral blood flow (CBF) during hypoxia and epileptic seizures. ( Dóra, E; Kovách, AG, 1985) |
| " Alterations in coronary flow were induced by hypoxia, amobarbital (Amytal) infusion, increase in work load of the heart, and adenosine infusion." | 3.66 | Role of mitochondrial oxidative phosphorylation in regulation of coronary blood flow. ( Erecińska, M; Nishiki, K; Nuutinen, EM; Wilson, DF, 1982) |
| "Tetrodotoxin has no accelerative effect on cerebral aerobic glycolysis." | 1.25 | Effects of tetrodotoxin and anaesthetics on brain metabolism and transport during anoxia. ( Quastel, JH; Shankar, R, 1972) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (85.71) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| ULOVICH, AI | 1 |
| CHANCE, B | 2 |
| SCHOENER, B | 1 |
| Huber, R | 1 |
| Spiegel, T | 1 |
| Büchner, M | 1 |
| Riepe, MW | 1 |
| Walter, P | 1 |
| Alteheld, N | 1 |
| Huth, J | 1 |
| Roessler, G | 1 |
| Vobig, MA | 1 |
| Dóra, E | 2 |
| Nuutinen, EM | 1 |
| Nishiki, K | 1 |
| Erecińska, M | 2 |
| Wilson, DF | 2 |
| Schaffer, SW | 1 |
| Croft, CB | 1 |
| Solodushko, V | 1 |
| Hafeman, DG | 1 |
| Lucas, ZJ | 1 |
| Benzi, G | 1 |
| Rumsey, WL | 1 |
| Kovách, AG | 1 |
| Sachs, G | 1 |
| Shoemaker, R | 1 |
| Hirschowitz, BI | 1 |
| Jöbsis, FF | 1 |
| Stainsby, WN | 1 |
| Jamieson, D | 1 |
| Terzuolo, CA | 1 |
| Handelman, E | 1 |
| Rossini, L | 2 |
| Schmelzer, P | 1 |
| Doane, MG | 1 |
| Liu, MS | 1 |
| Siess, M | 1 |
| Hoffmann, PC | 1 |
| Shankar, R | 1 |
| Quastel, JH | 1 |
| Arese, P | 1 |
| Bosia, A | 1 |
| Wilhjelm, BJ | 1 |
| Guseva, EA | 1 |
21 other studies available for amobarbital and Hypoxia
| Article | Year |
|---|---|
[Increased sensitivity and decreased resistance of the organism to narcotics, sedatives and analgesics in oxygen deficiency].
Topics: Amobarbital; Analgesics; Humans; Hypnotics and Sedatives; Hypoxia; Narcotics; Oxygen; Urethane | 1962 |
CONTROL OF OXIDATION-REDUCTION STATE OF NADH IN THE LIVER OF ANESTHETIZED RATS.
Topics: Amobarbital; Fluorescence; Fluorometry; Hypoxia; Kidney; Liver; Metabolism; NAD; Nitrogen; Oxidation | 1963 |
Graded reoxygenation with chemical inhibition of oxidative phosphorylation improves posthypoxic recovery in murine hippocampal slices.
Topics: Action Potentials; Amobarbital; Animals; Cyanides; Electron Transport Complex I; Electron Transport | 2004 |
Different states of energy metabolism in the vertebrate retina can be identified by stimulus-related changes in near UV transmission.
Topics: Amobarbital; Animals; Electron Transport; Electroretinography; Energy Metabolism; Glucose; Hypoxia; | 2007 |
A simple cranial window technique for optical monitoring of cerebrocortical microcirculation and NAD/NADH redox state. Effect of mitochondrial electron transport inhibitors and anoxic anoxia.
Topics: Amobarbital; Animals; Cats; Cerebral Cortex; Cyanides; Electron Transport; Fluorometry; Hypoxia; Mal | 1984 |
Role of mitochondrial oxidative phosphorylation in regulation of coronary blood flow.
Topics: Adenosine; Amobarbital; Animals; Calcium; Coronary Circulation; Hypoxanthines; Hypoxia; Inosine; Lac | 1982 |
Cardioprotective effect of chronic hyperglycemia: effect on hypoxia-induced apoptosis and necrosis.
Topics: Amobarbital; Animals; Apoptosis; bcl-Associated Death Protein; Calcium; Carrier Proteins; Chronic Di | 2000 |
Polymorphonuclear leukocyte-mediated, antibody-dependent, cellular cytotoxicity against tumor cells: dependence on oxygen and the respiratory burst.
Topics: Adenocarcinoma; Amobarbital; Animals; Antibody-Dependent Cell Cytotoxicity; Glucose; Humans; Hypoxia | 1979 |
An analysis of the drugs acting on cerebral energy metabolism.
Topics: Adenine Nucleotides; Amobarbital; Animals; Bemegride; Brain; Dipyridamole; Dogs; Energy Metabolism; | 1975 |
Relationship of myocardial metabolism and coronary flow: dependence on extracellular calcium.
Topics: Adenosine Triphosphate; Amobarbital; Animals; Calcium; Calcium Channel Blockers; Coronary Circulatio | 1987 |
Regulation of cerebral blood flow (CBF) during hypoxia and epileptic seizures.
Topics: 2-Chloroadenosine; Adenosine; Amobarbital; Animals; Cats; Cerebrovascular Circulation; Cyanides; Epi | 1985 |
The action of amytal on frog gastric mucosa.
Topics: Adenosine Triphosphate; Amobarbital; Animals; Anura; Biological Transport; Flavin-Adenine Dinucleoti | 1967 |
Oxidation of NADH during contractions of circulated mammalian skeletal muscle.
Topics: Amobarbital; Animals; Citric Acid Cycle; Dogs; Fluorometry; Glycolysis; Hypoxia; Ischemia; Lactates; | 1968 |
Ionizing radiation and the intracellular oxidation-reduction state.
Topics: Amobarbital; Animals; Ascites; Fluorescence; Hypoxia; Ileum; In Vitro Techniques; Kidney; NAD; NADP; | 1966 |
Measurements of reduced pyridine nucleotides in a single neuron.
Topics: Amobarbital; Citric Acid Cycle; Crustacea; Enzymes; Fluorometry; Glycolysis; Hypoxia; NADP; Neural C | 1966 |
Fluorometric measurement of pyridine nucleotide reduction in the giant axon of the squid.
Topics: Amobarbital; Animals; Axons; Azides; Cardanolides; Cyanides; Electric Stimulation; Electrochemistry; | 1967 |
The effect of changes in functional activity on ubiquinone redox status in isolated atria.
Topics: Amobarbital; Animals; Calcium; Electric Stimulation; Epinephrine; Freezing; Guinea Pigs; Heart; Hear | 1973 |
Effects of tetrodotoxin and anaesthetics on brain metabolism and transport during anoxia.
Topics: Action Potentials; Amobarbital; Anesthetics; Anesthetics, Local; Animals; Aspartic Acid; Calcium; Ca | 1972 |
Short-term effects of o-phenanthroline and amytal on glycolytic, Krebs-cycle and high-energy intermediates in the frog heart in vivo.
Topics: Amobarbital; Animals; Anura; Citric Acid Cycle; Energy Transfer; Glycolysis; Heart; Heart Ventricles | 1971 |
Effect of Tiomebumal upon resistance of mice to anoxia.
Topics: Amobarbital; Animals; Barbiturates; Brain; Carbon Dioxide; Hexobarbital; Hypoxia; Mice; Oxygen Consu | 1966 |
[The effect of sodium amytal on the development of anoxic nerve parabiosis].
Topics: Amobarbital; Animals; Anura; Hypoxia; Nervous System Physiological Phenomena; Parabiosis | 1966 |