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amobarbital and Hypoxia

amobarbital has been researched along with Hypoxia in 21 studies

Amobarbital: A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)
amobarbital : A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by a 3-methylbutyl and an ethyl group at position 5. Amobarbital has been shown to exhibit sedative and hypnotic properties.

Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.

Research Excerpts

ExcerptRelevanceReference
" Population spike amplitude (PSAP) and NADH were measured during hypoxic hypoxia (15 min) and recovery (45 min)."3.72Graded reoxygenation with chemical inhibition of oxidative phosphorylation improves posthypoxic recovery in murine hippocampal slices. ( Büchner, M; Huber, R; Riepe, MW; Spiegel, T, 2004)
"88 mM Amytal (amobarbital), hypoxia (95% N2-5% CO2), or 12 microM adenosine in the presence and absence of 2."3.67Relationship of myocardial metabolism and coronary flow: dependence on extracellular calcium. ( Erecińska, M; Rumsey, WL; Wilson, DF, 1987)
"In conclusion, our results suggest that neither the redox state of cytochrome oxidase nor adenosine are critical factors in the regulation of cerebral blood flow during arterial hypoxia and epileptic seizures."3.67Regulation of cerebral blood flow (CBF) during hypoxia and epileptic seizures. ( Dóra, E; Kovách, AG, 1985)
" Alterations in coronary flow were induced by hypoxia, amobarbital (Amytal) infusion, increase in work load of the heart, and adenosine infusion."3.66Role of mitochondrial oxidative phosphorylation in regulation of coronary blood flow. ( Erecińska, M; Nishiki, K; Nuutinen, EM; Wilson, DF, 1982)
"Tetrodotoxin has no accelerative effect on cerebral aerobic glycolysis."1.25Effects of tetrodotoxin and anaesthetics on brain metabolism and transport during anoxia. ( Quastel, JH; Shankar, R, 1972)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-199018 (85.71)18.7374
1990's0 (0.00)18.2507
2000's3 (14.29)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
ULOVICH, AI1
CHANCE, B2
SCHOENER, B1
Huber, R1
Spiegel, T1
Büchner, M1
Riepe, MW1
Walter, P1
Alteheld, N1
Huth, J1
Roessler, G1
Vobig, MA1
Dóra, E2
Nuutinen, EM1
Nishiki, K1
Erecińska, M2
Wilson, DF2
Schaffer, SW1
Croft, CB1
Solodushko, V1
Hafeman, DG1
Lucas, ZJ1
Benzi, G1
Rumsey, WL1
Kovách, AG1
Sachs, G1
Shoemaker, R1
Hirschowitz, BI1
Jöbsis, FF1
Stainsby, WN1
Jamieson, D1
Terzuolo, CA1
Handelman, E1
Rossini, L2
Schmelzer, P1
Doane, MG1
Liu, MS1
Siess, M1
Hoffmann, PC1
Shankar, R1
Quastel, JH1
Arese, P1
Bosia, A1
Wilhjelm, BJ1
Guseva, EA1

Other Studies

21 other studies available for amobarbital and Hypoxia

ArticleYear
[Increased sensitivity and decreased resistance of the organism to narcotics, sedatives and analgesics in oxygen deficiency].
    Arkhiv patologii, 1962, Volume: 24(3)

    Topics: Amobarbital; Analgesics; Humans; Hypnotics and Sedatives; Hypoxia; Narcotics; Oxygen; Urethane

1962
CONTROL OF OXIDATION-REDUCTION STATE OF NADH IN THE LIVER OF ANESTHETIZED RATS.
    Advances in enzyme regulation, 1963, Volume: 1

    Topics: Amobarbital; Fluorescence; Fluorometry; Hypoxia; Kidney; Liver; Metabolism; NAD; Nitrogen; Oxidation

1963
Graded reoxygenation with chemical inhibition of oxidative phosphorylation improves posthypoxic recovery in murine hippocampal slices.
    Journal of neuroscience research, 2004, Feb-01, Volume: 75, Issue:3

    Topics: Action Potentials; Amobarbital; Animals; Cyanides; Electron Transport Complex I; Electron Transport

2004
Different states of energy metabolism in the vertebrate retina can be identified by stimulus-related changes in near UV transmission.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2007, Volume: 245, Issue:4

    Topics: Amobarbital; Animals; Electron Transport; Electroretinography; Energy Metabolism; Glucose; Hypoxia;

2007
A simple cranial window technique for optical monitoring of cerebrocortical microcirculation and NAD/NADH redox state. Effect of mitochondrial electron transport inhibitors and anoxic anoxia.
    Journal of neurochemistry, 1984, Volume: 42, Issue:1

    Topics: Amobarbital; Animals; Cats; Cerebral Cortex; Cyanides; Electron Transport; Fluorometry; Hypoxia; Mal

1984
Role of mitochondrial oxidative phosphorylation in regulation of coronary blood flow.
    The American journal of physiology, 1982, Volume: 243, Issue:2

    Topics: Adenosine; Amobarbital; Animals; Calcium; Coronary Circulation; Hypoxanthines; Hypoxia; Inosine; Lac

1982
Cardioprotective effect of chronic hyperglycemia: effect on hypoxia-induced apoptosis and necrosis.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 278, Issue:6

    Topics: Amobarbital; Animals; Apoptosis; bcl-Associated Death Protein; Calcium; Carrier Proteins; Chronic Di

2000
Polymorphonuclear leukocyte-mediated, antibody-dependent, cellular cytotoxicity against tumor cells: dependence on oxygen and the respiratory burst.
    Journal of immunology (Baltimore, Md. : 1950), 1979, Volume: 123, Issue:1

    Topics: Adenocarcinoma; Amobarbital; Animals; Antibody-Dependent Cell Cytotoxicity; Glucose; Humans; Hypoxia

1979
An analysis of the drugs acting on cerebral energy metabolism.
    Japanese journal of pharmacology, 1975, Volume: 25, Issue:3

    Topics: Adenine Nucleotides; Amobarbital; Animals; Bemegride; Brain; Dipyridamole; Dogs; Energy Metabolism;

1975
Relationship of myocardial metabolism and coronary flow: dependence on extracellular calcium.
    The American journal of physiology, 1987, Volume: 253, Issue:5 Pt 2

    Topics: Adenosine Triphosphate; Amobarbital; Animals; Calcium; Calcium Channel Blockers; Coronary Circulatio

1987
Regulation of cerebral blood flow (CBF) during hypoxia and epileptic seizures.
    Advances in experimental medicine and biology, 1985, Volume: 191

    Topics: 2-Chloroadenosine; Adenosine; Amobarbital; Animals; Cats; Cerebrovascular Circulation; Cyanides; Epi

1985
The action of amytal on frog gastric mucosa.
    Biochimica et biophysica acta, 1967, Volume: 143, Issue:3

    Topics: Adenosine Triphosphate; Amobarbital; Animals; Anura; Biological Transport; Flavin-Adenine Dinucleoti

1967
Oxidation of NADH during contractions of circulated mammalian skeletal muscle.
    Respiration physiology, 1968, Volume: 4, Issue:3

    Topics: Amobarbital; Animals; Citric Acid Cycle; Dogs; Fluorometry; Glycolysis; Hypoxia; Ischemia; Lactates;

1968
Ionizing radiation and the intracellular oxidation-reduction state.
    Nature, 1966, Jan-22, Volume: 209, Issue:5021

    Topics: Amobarbital; Animals; Ascites; Fluorescence; Hypoxia; Ileum; In Vitro Techniques; Kidney; NAD; NADP;

1966
Measurements of reduced pyridine nucleotides in a single neuron.
    Biochimica et biophysica acta, 1966, Oct-10, Volume: 126, Issue:2

    Topics: Amobarbital; Citric Acid Cycle; Crustacea; Enzymes; Fluorometry; Glycolysis; Hypoxia; NADP; Neural C

1966
Fluorometric measurement of pyridine nucleotide reduction in the giant axon of the squid.
    The Journal of general physiology, 1967, Volume: 50, Issue:11

    Topics: Amobarbital; Animals; Axons; Azides; Cardanolides; Cyanides; Electric Stimulation; Electrochemistry;

1967
The effect of changes in functional activity on ubiquinone redox status in isolated atria.
    European journal of biochemistry, 1973, Aug-17, Volume: 37, Issue:2

    Topics: Amobarbital; Animals; Calcium; Electric Stimulation; Epinephrine; Freezing; Guinea Pigs; Heart; Hear

1973
Effects of tetrodotoxin and anaesthetics on brain metabolism and transport during anoxia.
    The Biochemical journal, 1972, Volume: 126, Issue:4

    Topics: Action Potentials; Amobarbital; Anesthetics; Anesthetics, Local; Animals; Aspartic Acid; Calcium; Ca

1972
Short-term effects of o-phenanthroline and amytal on glycolytic, Krebs-cycle and high-energy intermediates in the frog heart in vivo.
    Il Farmaco; edizione scientifica, 1971, Volume: 26, Issue:3

    Topics: Amobarbital; Animals; Anura; Citric Acid Cycle; Energy Transfer; Glycolysis; Heart; Heart Ventricles

1971
Effect of Tiomebumal upon resistance of mice to anoxia.
    International anesthesiology clinics, 1966,Summer, Volume: 4, Issue:2

    Topics: Amobarbital; Animals; Barbiturates; Brain; Carbon Dioxide; Hexobarbital; Hypoxia; Mice; Oxygen Consu

1966
[The effect of sodium amytal on the development of anoxic nerve parabiosis].
    Nervnaia sistema, 1966, Volume: 7

    Topics: Amobarbital; Animals; Anura; Hypoxia; Nervous System Physiological Phenomena; Parabiosis

1966