amobarbital has been researched along with Heart Disease, Ischemic in 5 studies
Amobarbital: A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)
amobarbital : A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by a 3-methylbutyl and an ethyl group at position 5. Amobarbital has been shown to exhibit sedative and hypnotic properties.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amobarbital-treated hearts received drug for 1 min before ischemia." | 1.33 | Blockade of electron transport before cardiac ischemia with the reversible inhibitor amobarbital protects rat heart mitochondria. ( Chen, Q; Hoppel, CL; Lesnefsky, EJ, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, M | 1 |
| Stowe, DF | 2 |
| Udoh, KB | 1 |
| Heisner, JS | 1 |
| Camara, AK | 2 |
| Chen, Q | 3 |
| Yin, G | 1 |
| Stewart, S | 1 |
| Hu, Y | 1 |
| Lesnefsky, EJ | 3 |
| Hoppel, CL | 1 |
| Aldakkak, M | 1 |
| Ambrosio, G | 1 |
| Zweier, JL | 1 |
| Duilio, C | 1 |
| Kuppusamy, P | 1 |
| Santoro, G | 1 |
| Elia, PP | 1 |
| Tritto, I | 1 |
| Cirillo, P | 1 |
| Condorelli, M | 1 |
| Chiariello, M | 1 |
5 other studies available for amobarbital and Heart Disease, Ischemic
| Article | Year |
|---|---|
Reversible blockade of complex I or inhibition of PKCĪ² reduces activation and mitochondria translocation of p66Shc to preserve cardiac function after ischemia.
Topics: Amobarbital; Animals; Electron Transport; Electron Transport Complex I; Enzyme Activation; Guinea Pi | 2014 |
Isolating the segment of the mitochondrial electron transport chain responsible for mitochondrial damage during cardiac ischemia.
Topics: Amobarbital; Animals; Cytochromes c; Disease Models, Animal; Electron Transport; Electron Transport | 2010 |
Blockade of electron transport before cardiac ischemia with the reversible inhibitor amobarbital protects rat heart mitochondria.
Topics: Amobarbital; Animals; Cardiotonic Agents; Citrate (si)-Synthase; Cytochromes; Dose-Response Relation | 2006 |
Inhibited mitochondrial respiration by amobarbital during cardiac ischaemia improves redox state and reduces matrix Ca2+ overload and ROS release.
Topics: Amobarbital; Animals; Calcium; Electron Transport Complex I; Flavin-Adenine Dinucleotide; Guinea Pig | 2008 |
Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow.
Topics: Adenosine Triphosphate; Amobarbital; Animals; Electron Spin Resonance Spectroscopy; Female; Free Rad | 1993 |