amobarbital has been researched along with Disease Models, Animal in 11 studies
Amobarbital: A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)
amobarbital : A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by a 3-methylbutyl and an ethyl group at position 5. Amobarbital has been shown to exhibit sedative and hypnotic properties.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Acute administration of tetrabenazine produced tremor in cats, in doses which caused sedation but not hypothermia." | 7.65 | Tremor induced by tetrabenazine. ( Calne, DB; Webster, RA, 1969) |
| " Acute administration of tetrabenazine produced tremor in cats, in doses which caused sedation but not hypothermia." | 3.65 | Tremor induced by tetrabenazine. ( Calne, DB; Webster, RA, 1969) |
| "Amobarbital treatment decreased cardiac injury and protected respiration." | 1.48 | Intermediary metabolism and fatty acid oxidation: novel targets of electron transport chain-driven injury during ischemia and reperfusion. ( Chen, Q; Hollander, JM; Hu, Y; Lesnefsky, EJ; Thompson, J; Younus, M, 2018) |
| " Improvement occurred after a single dose of the anxiolytic drugs but did not occur until 10-18 days after daily dosing with standard tricylic antidepressants and the MAO inhibitor isocarboxazid." | 1.27 | Effects of selected drugs on spontaneously occurring abnormal behavior in beagles. ( Barnett, A; Brody, PE; Eisenstein, N; Iorio, LC, 1983) |
| " The effect of administering activated charcoal at varying intervals after dosing on the blood drug-level profiles of paracetamol and amylobarbitone was assessed by comparison with the profiles obtained when charcoal therapy was withheld." | 1.25 | Studies with activated charcoal in the treatment of drug overdosage using the pig as an animal model. ( Lipscomb, DJ; Widdop, B, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (54.55) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Chen, Q | 2 |
| Younus, M | 1 |
| Thompson, J | 1 |
| Hu, Y | 2 |
| Hollander, JM | 1 |
| Lesnefsky, EJ | 2 |
| Yin, G | 1 |
| Stewart, S | 1 |
| Iorio, LC | 1 |
| Eisenstein, N | 1 |
| Brody, PE | 1 |
| Barnett, A | 1 |
| Chaloupka, JC | 1 |
| Viñuela, F | 1 |
| Sakai, N | 1 |
| Vinters, HV | 1 |
| Robert, J | 1 |
| Duckwiler, GR | 1 |
| Dunn, JA | 1 |
| Li, C | 1 |
| Ha, T | 1 |
| Kao, RL | 1 |
| Browder, W | 1 |
| Lipscomb, DJ | 1 |
| Widdop, B | 1 |
| Gloor, P | 2 |
| Testa, G | 2 |
| Guberman, A | 1 |
| Calne, DB | 1 |
| Webster, RA | 1 |
| Richardson, JS | 1 |
11 other studies available for amobarbital and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Intermediary metabolism and fatty acid oxidation: novel targets of electron transport chain-driven injury during ischemia and reperfusion.
Topics: Amobarbital; Animals; Disease Models, Animal; Electron Transport Chain Complex Proteins; Energy Meta | 2018 |
Isolating the segment of the mitochondrial electron transport chain responsible for mitochondrial damage during cardiac ischemia.
Topics: Amobarbital; Animals; Cytochromes c; Disease Models, Animal; Electron Transport; Electron Transport | 2010 |
Effects of selected drugs on spontaneously occurring abnormal behavior in beagles.
Topics: Amobarbital; Animals; Antidepressive Agents; Arousal; Behavior, Animal; Chlordiazepoxide; Diazepam; | 1983 |
Potential toxic effects of superselective injection of amobarbital sodium on microvasculature: a study in an animal model.
Topics: Amobarbital; Animals; Capillaries; Catheterization, Peripheral; Cerebral Angiography; Cerebral Arter | 1994 |
Therapeutic modification of nuclear factor kappa B binding activity and tumor necrosis factor-alpha gene expression during acute biliary pancreatitis.
Topics: Acute Disease; Amobarbital; Amylases; Animals; Bilirubin; Cholestasis; Disease Models, Animal; Elect | 1997 |
Studies with activated charcoal in the treatment of drug overdosage using the pig as an animal model.
Topics: Acetaminophen; Administration, Oral; Amitriptyline; Amobarbital; Animals; Charcoal; Disease Models, | 1975 |
Generalized penicillin epilepsy in the cat: effects of intracarotid and intravertebral pentylenetetrazol and amobarbital injections.
Topics: Amobarbital; Animals; Brain Stem; Carotid Arteries; Cats; Cerebral Cortex; Disease Models, Animal; E | 1974 |
Brain-stem and cortical mechanisms in an animal model of generalized corticoreticular epilepsy.
Topics: Amobarbital; Animals; Arousal; Brain Stem; Cats; Cerebral Cortex; Cortical Synchronization; Disease | 1973 |
Tremor induced by tetrabenazine.
Topics: Amobarbital; Animals; Body Temperature; Cats; Disease Models, Animal; Hot Temperature; Parkinson Dis | 1969 |
The self-injection of amobarbital by rats during non-reward.
Topics: Amobarbital; Animals; Avoidance Learning; Behavior, Animal; Cardiac Catheterization; Conditioning, O | 1970 |