amobarbital and Depression studies

Amobarbital: A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)
amobarbital : A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by a 3-methylbutyl and an ethyl group at position 5. Amobarbital has been shown to exhibit sedative and hypnotic properties.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

Excerpt	Relevance	Reference
"Seventy unwed pregnant patients in states of mild to moderate depression evidenced by one or more symptoms (tenseness, "nervousness," crying spells, listlessness, fatigue, nausea and vomiting, insomnia and overeating), received informal psychotherapy and a sustained-release capsule combining d-amphetamine sulfate and amobarbital."	7.63	Prepartum depression; a study of seventy unwed mothers treated with d-amphetamine sulfate and amobarbital. ( CALDWELL, WG; NOWERS, W, 1958)
"Seventy unwed pregnant patients in states of mild to moderate depression evidenced by one or more symptoms (tenseness, "nervousness," crying spells, listlessness, fatigue, nausea and vomiting, insomnia and overeating), received informal psychotherapy and a sustained-release capsule combining d-amphetamine sulfate and amobarbital."	3.63	Prepartum depression; a study of seventy unwed mothers treated with d-amphetamine sulfate and amobarbital. ( CALDWELL, WG; NOWERS, W, 1958)
"A controlled double-blind trial of amitriptyline at two dosage levels (75 and 150 mg/day), amylobarbitone (150 mg/day), and an inert substance for a period of four weeks was conducted on four matched groups of women attending their general practitioners and suffering from a depressive illness."	2.64	Controlled trial of amitriptyline in general practice. ( Blashki, TG; Davies, B; Mowbray, R, 1971)

Timeframe	Studies, this research(%)	All Research%
pre-1990	52 (96.30)	18.7374
1990's	2 (3.70)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
GOTTLIEB, JS	3
KNOTT, JR	1
KIMBLE, LL	1
FEATHERSTONE, RM	1
CARTER, HR	1
COHEN, BD	2
SENF, R	3
HUSTON, PE	3
GRAHN, HV	1
CALDWELL, WG	1
NOWERS, W	1
FEIGLEY, DM	1
HONIGFELD, G	1
LASKY, JJ	1
BOVI, A	1
MARTELLI, G	1
PERRIS, C	1
BRATTEMO, CE	1
HARE, EH	1
MCCANCE, C	1
MCCORMICK, WO	1
LEHMANN, HE	1
BAN, TA	1
WALLING, RG	1
DAVISON, K	1
FORREST, AD	1
TIMOFEEVA, AN	1
LIPSKAIA, LA	1
AINSLIE, JD	1
JONES, MB	1
STIEFEL, JR	1
MARTIN, I	1
DAVIES, BM	1
STARK, JE	1
BETHUNE, DW	1
HINTON, JM	1
Kutsenok, BM	1
Kraines, SH	2
Lee, GP	1
Loring, DW	1
Meador, KJ	1
Dysken, MW	1
Kooser, JA	1
Haraszti, JS	1
Davis, JM	1
Geffen, G	1
Traub, E	1
Stierman, I	1
Shagass, C	1
Whyte, SF	1
Macdonald, AJ	1
Naylor, GJ	1
Moody, JP	1
Kurthen, M	1
Linke, DB	1
Reuter, BM	1
Hufnagel, A	1
Elger, CE	1
Weller, EB	1
Weller, RA	1
Fristad, MA	1
Wheatley, D	1
Ballinger, BR	1
Presly, A	1
Reid, AH	1
Stevenson, IH	1
Hoffman, PB	1
Faris, AM	1
Fink, M	1
Cawley, RH	1
Post, F	1
Whitehead, A	1
Tan, BK	1
Ridgers, A	1
Gray, JA	1
Davies, C	1
Levine, S	1
Hunter, JW	1
Owen, S	1
Eksi, A	1
Scott, JF	1
Guthrie, MB	1
Free, SM	1
Bond, MR	1
Pearson, IB	1
Seager, CP	1
Blashki, TG	1
Mowbray, R	1
Davies, B	1
Lader, MH	1
Kellner, R	1
Ferris, GN	1
Denson, R	1
Saunders, WA	1
Johnson, FG	1
Traugott, NN	1
Kaufman, DA	1
Sours, JA	1
Mann, J	1

Article	Year
EEG and evoked potentials in the psychoses. Research publications - Association for Research in Nervous and Mental Disease, 1975, Volume: 54 Topics: Adjustment Disorders; Alpha Rhythm; Amobarbital; Bipolar Disorder; Depression; Electroencephalograph	1975
CNS effects of convulsive therapy: significance for a theory of depressive psychosis. Proceedings of the annual meeting of the American Psychopathological Association, 1972, Volume: 60 Topics: Alpha Rhythm; Amobarbital; Antidepressive Agents; Bipolar Disorder; Brain; Depression; Electroconvul	1972
Physiological measures in psychiatry. The Scientific basis of medicine annual reviews, 1971 Topics: Adaptation, Psychological; Amobarbital; Animals; Anxiety; Arousal; Blood Pressure; Depression; Elect	1971

Article	Year
Clinical usefulness of sodium amobarbital interviewing. Archives of general psychiatry, 1979, Volume: 36, Issue:7 Topics: Adult; Amobarbital; Brief Psychiatric Rating Scale; Communication; Depression; Double-Blind Method;	1979
Influence of doctors' and patients' attitudes in the treatment of neurotic illness. Lancet (London, England), 1967, Nov-25, Volume: 2, Issue:7526 Topics: Amitriptyline; Amobarbital; Anxiety Disorders; Attitude; Chlordiazepoxide; Clinical Trials as Topic;	1967
A controlled comparison of nitrazepam ('mogadon') with sodium amylobarbitone as a sleep-inducing agent. The British journal of psychiatry : the journal of mental science, 1967, Volume: 113, Issue:502 Topics: Amobarbital; Clinical Trials as Topic; Depression; Female; Humans; Hypnotics and Sedatives; Male; Mi	1967
A controlled cross-over study of trimipramine and amylobarbitone. The British journal of psychiatry : the journal of mental science, 1967, Volume: 113, Issue:499 Topics: Amobarbital; Clinical Trials as Topic; Depression; Dibenzazepines; Humans; Neurotic Disorders; Place	1967
Response to trifluoperazine-amobarbital in outpatients with anxiety. (A double-blind, placebo-controlled study). Diseases of the nervous system, 1969, Volume: 30, Issue:3 Topics: Adult; Aged; Amobarbital; Anxiety Disorders; Clinical Trials as Topic; Depression; Female; Humans; M	1969
Sleeping pills. British medical journal, 1970, Sep-05, Volume: 3, Issue:5722 Topics: Amobarbital; Clinical Trials as Topic; Depression; Electroconvulsive Therapy; Humans; Middle Aged; P	1970
Controlled trial of amitriptyline in general practice. British medical journal, 1971, Jan-16, Volume: 1, Issue:5741 Topics: Adolescent; Adult; Amitriptyline; Amobarbital; Anxiety; Clinical Trials as Topic; Depression; Family	1971
1. Improvement criteria in drug trials with neurotic patients. Psychological medicine, 1971, Volume: 1, Issue:5 Topics: Amobarbital; Chlordiazepoxide; Clinical Trials as Topic; Depression; Evaluation Studies as Topic; Hu	1971
Chlordiazepoxide in anxiety states. The Practitioner, 1965, Volume: 195, Issue:169 Topics: Adolescent; Adult; Aged; Amobarbital; Anxiety; Chlordiazepoxide; Clinical Trials as Topic; Depressio	1965
Lysergide in the treatment of neurosis. (A report of two cases). Diseases of the nervous system, 1966, Volume: 27, Issue:8 Topics: Adult; Amobarbital; Antisocial Personality Disorder; Anxiety Disorders; Clinical Trials as Topic; De	1966

Article	Year
Psychopharmacologic study of schizophrenia and depression; the influence of electric convulsive therapy on the sodium amytal response of the electroencephalogram. The American journal of psychiatry, 1948, Volume: 104, Issue:11 Topics: Amobarbital; Depression; Depressive Disorder; Electroconvulsive Therapy; Electroencephalography; Hum	1948
Psychopharmacologic study of schizophrenia and depressions; lactic and pyruvic acid content of the blood before and after administration of sodium amytal. Archives of neurology and psychiatry, 1947, Volume: 58, Issue:2 Topics: Amobarbital; Brain; Depression; Nervous System Physiological Phenomena; Pyruvic Acid; Schizophrenia	1947
Effect of amobarbital (amytal) and affect on conceptual thinking in schizophrenia, depression, and neurosis. A.M.A. archives of neurology and psychiatry, 1954, Volume: 71, Issue:2 Topics: Amobarbital; Barbiturates; Depression; Emotions; Humans; Neurotic Disorders; Schizophrenia; Schizoph	1954
Use of a d-amphetamine-amobarbital combination as an adjunct to the treatment of carcinoma. Journal of the American Geriatrics Society, 1954, Volume: 2, Issue:9 Topics: Amobarbital; Amphetamine; Amphetamines; Anxiety; Barbiturates; Depression; Depressive Disorder; Dext	1954
Perceptual accuracy in schizophrenia, depression, and neurosis, and effects of amytal. Journal of abnormal psychology, 1956, Volume: 52, Issue:3 Topics: Amobarbital; Amphetamine; Amphetamines; Barbiturates; Depression; Depressive Disorder; Humans; Neuro	1956
Prepartum depression; a study of seventy unwed mothers treated with d-amphetamine sulfate and amobarbital. California medicine, 1958, Volume: 88, Issue:5 Topics: Amobarbital; Amphetamine; Amphetamines; Anxiety; Apathy; Depression; Depressive Disorder; Dextroamph	1958
Office care of mild emotional distress. Diseases of the nervous system, 1962, Volume: 23 Topics: Amobarbital; Amphetamine; Amphetamines; Anxiety; Anxiety Disorders; Atropa belladonna; Depression; D	1962
One year follow-up of depressed patients treated in a multi-hospital drug study. I. Social workers' evaluations. Diseases of the nervous system, 1962, Volume: 23 Topics: Amobarbital; Depression; Depressive Disorder; Dextroamphetamine; Drug Evaluation; Follow-Up Studies;	1962
[MENTAL CHANGES INDUCED WITH ENDOCAROTID AMYTAL IN DYSTHYMIC SUBJECTS. PRELIMINARY NOTE]. Rivista sperimentale di freniatria e medicina legale delle alienazioni mentali, 1963, Jun-30, Volume: 87 Topics: Amobarbital; Bipolar Disorder; Depression; Depressive Disorder; Humans; Hypochondriasis; Mental Diso	1963
THE SEDATION THRESHOLD AS A METHOD OF EVALUATING ANTI-DEPRESSIVE TREATMENTS; A PRELIMINARY REPORT. Acta psychiatrica Scandinavica, 1963, Volume: 39 Topics: Amobarbital; Anxiety; Anxiety Disorders; Depression; Depressive Disorder; Electroencephalography; Hu	1963
IMIPRAMINE AND "DRINAMYL" IN DEPRESSIVE ILLNESS: A COMPARATIVE TRIAL. British medical journal, 1964, Mar-28, Volume: 1, Issue:5386 Topics: Amobarbital; Antidepressive Agents; Depression; Depressive Disorder; Dextroamphetamine; Imipramine;	1964
NOTES FROM THE LOG-BOOK OF A PSYCHOPHARMACOLOGICAL RESEARCH UNIT I. Canadian Psychiatric Association journal, 1964, Volume: 9 Topics: Amobarbital; Behavior; Books; Chlordiazepoxide; Depression; Dextroamphetamine; Electroconvulsive The	1964
DEPRESSIONS... THEIR MANAGEMENT AND TREATMENT. The Journal of the Arkansas Medical Society, 1964, Volume: 60 Topics: Amitriptyline; Amobarbital; Bipolar Disorder; Depression; Depressive Disorder; Electroconvulsive The	1964
EPISODIC DEPERSONALIZATION; OBSERVATIONS ON 7 PATIENTS. The British journal of psychiatry : the journal of mental science, 1964, Volume: 110 Topics: Alcoholic Beverages; Amitriptyline; Amobarbital; Cochlea; Convulsive Therapy; Depersonalization; Dep	1964
DRUGS FOR DEPRESSION. British medical journal, 1964, Sep-19, Volume: 2, Issue:5411 Topics: Amobarbital; Antidepressive Agents; Chlordiazepoxide; Depression; Depressive Disorder; Dextroampheta	1964
[BARBAMYL-TOFRANIL TEST IN THE EVALUATION OF THE DEPRESSIVE STATE]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1963, Volume: 63 Topics: Amobarbital; Anxiety; Anxiety Disorders; Bipolar Disorder; Delirium; Delusions; Depression; Depressi	1963
PRACTICAL DRUG EVALUATION METHOD: IMIPRAMINE IN DEPRESSED OUTPATIENTS. Archives of general psychiatry, 1965, Volume: 12 Topics: Amobarbital; Biomedical Research; Chlordiazepoxide; Chlorpromazine; Depression; Depressive Disorder;	1965
THE EFFECT OF SODIUM AMYTAL ON AUTONOMIC AND MUSCLE ACTIVITY IN PATIENTS WITH DEPRESSIVE ILLNESS. The British journal of psychiatry : the journal of mental science, 1965, Volume: 111 Topics: Amobarbital; Autonomic Nervous System; Blood Pressure; Depression; Electromyography; Galvanic Skin R	1965
AMITRIPTYLINE POISONING. Lancet (London, England), 1965, Aug-21, Volume: 2, Issue:7408 Topics: Amitriptyline; Amobarbital; Barbiturates; Coma; Depression; Depressive Disorder; Diuresis; Drug Ther	1965
A comparison of perphenazine, ('fentazin') sodium amylobarbitone and a placebo in anxious and depressed out-patients. The Journal of mental science, 1959, Volume: 105 Topics: Amobarbital; Anxiety; Anxiety Disorders; Depression; Depressive Disorder; Humans; Outpatients; Perph	1959
Psychopathology of schizophrenia and depression. I. Effect of amytal and amphetamine sulfate on level and maintenance of attention. The American journal of psychiatry, 1952, Volume: 109, Issue:2 Topics: Aged; Amobarbital; Amphetamine; Attention; Depression; Depressive Disorder; Humans; Psychopathology;	1952
The use of sodium amytal and benzedrine sulfate in the symptomatic treatment of depressions. Diseases of the nervous system, 1949, Volume: 10, Issue:2 Topics: Amobarbital; Amphetamine; Depression; Depressive Disorder; Sulfates; Sulfur Oxides	1949
[On the differential diagnosis of relapsing schizophrenia]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1966, Volume: 66, Issue:9 Topics: Adolescent; Adult; Amobarbital; Catatonia; Delirium; Depression; Diagnosis, Differential; Female; Ha	1966
Sodium amytal, hypnosis, and psychotherapy. International journal of neuropsychiatry, 1967, Volume: 3, Issue:3 Topics: Adolescent; Adult; Aged; Amobarbital; Attitude; Blood Pressure; Depression; Female; Humans; Hypnosis	1967
Therapy of the chronic depressions. Diseases of the nervous system, 1967, Volume: 28, Issue:9 Topics: Alcoholism; Amobarbital; Anorexia Nervosa; Antidepressive Agents; Chronic Disease; Convulsive Therap	1967
Influence of premorbid personality and location of lesion on emotional expression. The International journal of neuroscience, 1993, Volume: 72, Issue:3-4 Topics: Adult; Amobarbital; Carotid Artery, Internal; Depression; Dominance, Cerebral; Emotions; Epilepsy, C	1993
Language laterality assessed by unilateral ECT and dichotic monitoring. Journal of neurology, neurosurgery, and psychiatry, 1978, Volume: 41, Issue:4 Topics: Adolescent; Adult; Amobarbital; Auditory Perception; Child; Deglutition Disorders; Depression; Domin	1978
Plasma concentrations of protriptyline and clinical effects in depressed women. The British journal of psychiatry : the journal of mental science, 1976, Volume: 128 Topics: Adjustment Disorders; Administration, Oral; Adolescent; Adult; Aged; Amobarbital; Depression; Dibenz	1976
Severe negative emotional reactions in intracarotid sodium amytal procedures: further evidence for hemispheric asymmetries? Cortex; a journal devoted to the study of the nervous system and behavior, 1991, Volume: 27, Issue:2 Topics: Adult; Amobarbital; Arousal; Carotid Arteries; Depression; Dominance, Cerebral; Electroencephalograp	1991
Use of sodium amytal interviews in prepubertal children: indications, procedure, and clinical utility. Journal of the American Academy of Child Psychiatry, 1985, Volume: 24, Issue:6 Topics: Amobarbital; Child; Depression; Developmental Disabilities; Female; Humans; Male; Mental Disorders;	1985
The effects of hypnotics on imipramine treatment. Psychopharmacologia, 1974, Volume: 39, Issue:3 Topics: Adult; Amobarbital; Depression; Desipramine; Drug Interactions; Drug Therapy, Combination; Female; H	1974
Psychiatric interventions with amnesic aircraft accident survivors. Aerospace medicine, 1974, Volume: 45, Issue:11 Topics: Accidents, Aviation; Aerospace Medicine; Amnesia; Amobarbital; Depression; Forensic Medicine; Humans	1974
Barbiturate tolerance and psychological functioning in elderly depressed patients. Psychological medicine, 1973, Volume: 3, Issue:1 Topics: Adult; Aged; Amitriptyline; Amobarbital; Arousal; Cognition; Depression; Drug Tolerance; Electroconv	1973
Autonomic correlates of the sedation threshold. Canadian Psychiatric Association journal, 1973, Volume: 18, Issue:3 Topics: Adult; Amobarbital; Analysis of Variance; Autonomic Nervous System; Depression; Dose-Response Relati	1973
Influence of amylobarbitone on operant depression and elation effects in the rat. Psychopharmacologia, 1973, Sep-28, Volume: 32, Issue:3 Topics: Amobarbital; Animals; Behavior, Animal; Conditioning, Operant; Depression; Emotions; Humans; Male; R	1973
Addiction to Daprisal. Southern medical journal, 1972, Volume: 65, Issue:2 Topics: Adult; Amobarbital; Aspirin; Depression; Dextroamphetamine; Drug Combinations; Female; Humans; Male;	1972
Organic or psychogenic stupor. British medical journal, 1970, Feb-07, Volume: 1, Issue:5692 Topics: Adult; Amobarbital; Cognition Disorders; Depression; Female; Hemiplegia; Humans	1970
A comparison of short-term treatment effects of intravenous sodium amytal-methedrine and LSD in the alcoholic. Canadian Psychiatric Association journal, 1970, Volume: 15, Issue:5 Topics: Affect; Alcoholism; Amobarbital; Anxiety; Canada; Depression; Hallucinations; Humans; Injections, In	1970
[Mechanisms of short-term memory]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova, 1971, Volume: 21, Issue:2 Topics: Amobarbital; Amphetamine; Chlorpromazine; Depression; Humans; Hypothalamus; Imipramine; Memory, Shor	1971
Addiction to daprisal. JAMA, 1968, Sep-23, Volume: 205, Issue:13 Topics: Adult; Amobarbital; Analgesics; Aspirin; Depression; Dextroamphetamine; Humans; Phenacetin; Substanc	1968
The use of sodium amobarbital in psychiatry. The Ohio State medical journal, 1969, Volume: 65, Issue:7 Topics: Adult; Amobarbital; Depression; Humans; Hysteria; Interview, Psychological; Male; Memory Disorders;	1969

amobarbital and Depression

Research Excerpts

Research

Studies (54)

Authors

Reviews

Trials

Other Studies