Page last updated: 2024-10-22

amobarbital and Coma

amobarbital has been researched along with Coma in 12 studies

Amobarbital: A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)
amobarbital : A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by a 3-methylbutyl and an ethyl group at position 5. Amobarbital has been shown to exhibit sedative and hypnotic properties.

Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.

Research Excerpts

ExcerptRelevanceReference
" A condition for antidote effect of the Krebs intermediate was sufficiently high dosage (5 mmol/kg), further dose increase made no odds."1.32Intermediates of Krebs cycle correct the depression of the whole body oxygen consumption and lethal cooling in barbiturate poisoning in rat. ( Ivnitsky, JJ; Malakhovsky, VN; Rejniuk, VL; Schäfer, TV, 2004)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-199010 (83.33)18.7374
1990's1 (8.33)18.2507
2000's1 (8.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
SUNSHINE, P1
YAFFE, SJ1
DOBROVOLSKAIA, TI1
POROSHINA, IuA1
KORKINA, MV1
MULLAN, D1
PLATTS, M1
RIDGWAY, B1
STARK, JE1
BETHUNE, DW1
Ivnitsky, JJ1
Schäfer, TV1
Malakhovsky, VN1
Rejniuk, VL1
Goulon, M1
Nouailhat, F1
Lévy-Alcover, MA1
Dordain, G1
Richard, B1
Honer, WG1
Rosenberg, RG1
Turey, M1
Fisher, WA1
Carroll, BJ1
Mandy, S1
Ackerman, AB1
Fournier, E1
Kaloyanova, F1
Treich, I1
Capelle, N1
Lous, P1

Other Studies

12 other studies available for amobarbital and Coma

ArticleYear
AMITRIPTYLINE POISONING. CLINICAL AND PATHOLOGICAL FINDINGS IN A FATAL CASE.
    American journal of diseases of children (1960), 1963, Volume: 106

    Topics: Amitriptyline; Amobarbital; Antidepressive Agents; Apnea; Arrhythmias, Cardiac; Coma; Dialysis; Flui

1963
[TOXIC ENCEPHALOPATHY DEVELOPED AFTER INSULIN INTOXICATION].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1963, Volume: 63

    Topics: Amobarbital; Brain Diseases; Coma; Insulin; Insulin Coma; Neurotoxicity Syndromes; Toxicology

1963
BARBITURATE INTOXICATION.
    Lancet (London, England), 1965, Mar-27, Volume: 1, Issue:7387

    Topics: Amobarbital; Barbiturates; Coma; Diagnosis; Electrocardiography; Hypnotics and Sedatives; Hypoxia, B

1965
AMITRIPTYLINE POISONING.
    Lancet (London, England), 1965, Aug-21, Volume: 2, Issue:7408

    Topics: Amitriptyline; Amobarbital; Barbiturates; Coma; Depression; Depressive Disorder; Diuresis; Drug Ther

1965
Intermediates of Krebs cycle correct the depression of the whole body oxygen consumption and lethal cooling in barbiturate poisoning in rat.
    Toxicology, 2004, Oct-01, Volume: 202, Issue:3

    Topics: Amobarbital; Animals; Antidotes; Body Temperature; Citric Acid Cycle; Coma; Female; Hypnotics and Se

2004
[Toxic coma with autonomic sideration, with a favorable outcome].
    Revue neurologique, 1967, Volume: 116, Issue:4

    Topics: Adult; Amobarbital; Body Temperature; Brain; Cardiovascular System; Chlorpromazine; Coma; Diazepam;

1967
[Drug addiction to amobarbital].
    Presse medicale (Paris, France : 1983), 1990, Sep-22, Volume: 19, Issue:30

    Topics: Adolescent; Amobarbital; Coma; Humans; Substance-Related Disorders

1990
Respiratory failure after clonazepam and amobarbital.
    The American journal of psychiatry, 1986, Volume: 143, Issue:11

    Topics: Amobarbital; Clonazepam; Coma; Drug Therapy, Combination; Humans; Male; Middle Aged; Psychotic Disor

1986
Barbiturate overdosage: presentation with focal neurological signs.
    The Medical journal of Australia, 1969, May-31, Volume: 1, Issue:22

    Topics: Adult; Alcoholism; Amobarbital; Barbiturates; Basilar Artery; Bromides; Cerebral Hemorrhage; Coma; C

1969
Characteristic traumatic skin lesions in drug-induced coma.
    JAMA, 1970, Jul-13, Volume: 213, Issue:2

    Topics: Adult; Amobarbital; Barbiturates; Biopsy; Blister; Coma; Erythema; Heroin; Humans; Male; Nalorphine;

1970
[Application of gas chromatography to the identification and determination of barbiturate derivatives in the blood during acute poisoning].
    European journal of toxicology, 1970, Volume: 3, Issue:5

    Topics: Amobarbital; Barbiturates; Chemistry, Clinical; Chromatography, Gas; Coma; Humans; Methods; Methylat

1970
Elimination of barbiturates.
    International anesthesiology clinics, 1966,Summer, Volume: 4, Issue:2

    Topics: Adult; Amobarbital; Barbiturates; Coma; Female; Humans; Pentobarbital; Phenobarbital; Thiopental

1966