amobarbital has been researched along with Chemical and Drug Induced Liver Injury in 5 studies
Amobarbital: A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)
amobarbital : A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by a 3-methylbutyl and an ethyl group at position 5. Amobarbital has been shown to exhibit sedative and hypnotic properties.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Drug-metabolizing capacity has been assessed by serial measurements of the plasma antipyrine half life in 11 patients with severe barbiturate intoxication and in 17 patients with acute hepatic necrosis due to paracetamol overdosage." | 3.65 | Abnormal drug metabolism after barbiturate and paracetamol overdose. ( Forrest, JA; Prescott, LF; Roscoe, P; Stevenson, IH, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Mitchell, JR | 1 |
| Thorgeirsson, SS | 1 |
| Potter, WZ | 1 |
| Jollow, DJ | 1 |
| Keiser, H | 1 |
| Forrest, JA | 1 |
| Roscoe, P | 1 |
| Prescott, LF | 2 |
| Stevenson, IH | 1 |
| Wrights, N | 1 |
| Franken, FH | 1 |
| Hagelskamp, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00799578] | Phase 1/Phase 2 | 13 participants (Actual) | Interventional | 2008-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00799578)
Timeframe: 6 months
| Intervention | participants (Number) |
|---|---|
| Number of Improved Subjects | 7 |
5 other studies available for amobarbital and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy.
Topics: Acetaminophen; Acetylcysteine; Adult; Amobarbital; Animals; Chemical and Drug Induced Liver Injury; | 1974 |
Abnormal drug metabolism after barbiturate and paracetamol overdose.
Topics: Acetaminophen; Adult; Aged; Alanine Transaminase; Amobarbital; Antipyrine; Barbiturates; Bilirubin; | 1974 |
Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage.
Topics: Acetaminophen; Adolescent; Adult; Amobarbital; Aspartate Aminotransferases; Bilirubin; Chemical and | 1973 |
[Barbiturates and liver].
Topics: Amobarbital; Animals; Barbiturates; Chemical and Drug Induced Liver Injury; Enzyme Activation; Fatty | 1970 |