Page last updated: 2024-10-22

amobarbital and Ache

amobarbital has been researched along with Ache in 26 studies

Amobarbital: A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)
amobarbital : A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by a 3-methylbutyl and an ethyl group at position 5. Amobarbital has been shown to exhibit sedative and hypnotic properties.

Research Excerpts

ExcerptRelevanceReference
"Sodium amobarbital decreased spontaneous pain by 73% (vs 46% with lidocaine) and normalized sensory abnormalities at or above the level of injury in 3 patients (as compared to just 1 patient with lidocaine), 2 of whom had transitional zone allodynia/hyperalgesia."9.14Effects of intravenous sodium amobarbital vs lidocaine on pain and sensory abnormalities in patients with spinal cord injury. ( Bharatwal, B; Krassioukov, AV; Mailis-Gagnon, A; Yegneswaran, B, 2009)
"A mitochondrial electron transport chain member complex I inhibitor, amobarbital, can reduce oxidative damage and chondrocyte death, eventually preventing post-traumatic osteoarthritis (PTOA)."8.12HPLC-UV Method Validation for Amobarbital and Pharmaceutical Stability Evaluation When Dispersed in a Hyaluronic Acid Hydrogel: A New Concept for Post-Traumatic Osteoarthritis Prevention. ( Chakka, JL; Martin, JA; Naguib, YW; Quarterman, JC; Salem, AK; Seol, D, 2022)
"Sodium amobarbital decreased spontaneous pain by 73% (vs 46% with lidocaine) and normalized sensory abnormalities at or above the level of injury in 3 patients (as compared to just 1 patient with lidocaine), 2 of whom had transitional zone allodynia/hyperalgesia."5.14Effects of intravenous sodium amobarbital vs lidocaine on pain and sensory abnormalities in patients with spinal cord injury. ( Bharatwal, B; Krassioukov, AV; Mailis-Gagnon, A; Yegneswaran, B, 2009)
"A mitochondrial electron transport chain member complex I inhibitor, amobarbital, can reduce oxidative damage and chondrocyte death, eventually preventing post-traumatic osteoarthritis (PTOA)."4.12HPLC-UV Method Validation for Amobarbital and Pharmaceutical Stability Evaluation When Dispersed in a Hyaluronic Acid Hydrogel: A New Concept for Post-Traumatic Osteoarthritis Prevention. ( Chakka, JL; Martin, JA; Naguib, YW; Quarterman, JC; Salem, AK; Seol, D, 2022)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199021 (80.77)18.7374
1990's2 (7.69)18.2507
2000's2 (7.69)29.6817
2010's0 (0.00)24.3611
2020's1 (3.85)2.80

Authors

AuthorsStudies
Quarterman, JC1
Naguib, YW1
Chakka, JL1
Seol, D1
Martin, JA1
Salem, AK1
Mailis-Gagnon, A2
Yegneswaran, B1
Bharatwal, B1
Krassioukov, AV1
DIONESOV, SM1
TOLOKOVA, NA1
DAVIS, JD1
MILLER, NE1
ZEPPENFELD, I1
Sa, DS1
Nicholson, K1
Lang, AE1
Peck, RE2
Mettler, L1
Sadighi, R1
Mailis, A2
Plapler, P1
Ashby, P1
Shoichet, R1
Roe, S2
Amani, N1
Umana, M1
Basur, R1
Shoichet, RP1
Hartmann, G1
Ravry, MJ1
Borlich, DR1
Knoll, J1
Fürst, S1
Mészáros, Z1
Grayson, MF1
Huskisson, EC1
Schiller, U1
Holsten, E1
Raymann, F1
Faust, B1
Arnemann, W1
Beecher, HK1
Melikoglu, S1
Timar, M1
Sauvard, L1
Botez, A1
Simionovici, M1
Winter, D1
Georgescu, CM1
Cristescu, C1
Panaitescu, T1
Schleith, K1

Trials

6 trials available for amobarbital and Ache

ArticleYear
Effects of intravenous sodium amobarbital vs lidocaine on pain and sensory abnormalities in patients with spinal cord injury.
    The journal of spinal cord medicine, 2009, Volume: 32, Issue:1

    Topics: Adult; Amobarbital; Anesthetics, Local; Female; Humans; Hypnotics and Sedatives; Injections, Intrave

2009
Effect of intravenous sodium amytal on cutaneous limb temperatures and sympathetic skin responses in normal subjects and pain patients with and without Complex Regional Pain Syndromes (type I and II). I.
    Pain, 1997, Volume: 70, Issue:1

    Topics: Adult; Aged; Amobarbital; Body Temperature; Causalgia; Extremities; Female; Galvanic Skin Response;

1997
Effect of intravenous sodium amytal on cutaneous sensory abnormalities, spontaneous pain and algometric pain pressure thresholds in neuropathic pain patients: a placebo-controlled study. II.
    Pain, 1997, Volume: 70, Issue:1

    Topics: Adult; Amobarbital; Female; Humans; Hypnotics and Sedatives; Injections, Intravenous; Male; Middle A

1997
A sequential trial of indomethacin and sodium amylobarbitone at night in rheumatoid arthritis, with comments on the statistical method.
    Rheumatology and rehabilitation, 1974, Volume: 13, Issue:4

    Topics: Amobarbital; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Ind

1974
[Therapeutic findings with a new, both sedative and spasmolytically-active analgesic].
    Die Therapiewoche, 1965, Volume: 15, Issue:11

    Topics: Aminopyrine; Amobarbital; Clinical Trials as Topic; Codeine; Humans; Pain; Scopolamine

1965
[On analgesic therapy in a surgical patient register].
    Deutsches medizinisches Journal, 1965, Jul-05, Volume: 16, Issue:13

    Topics: Aminopyrine; Amobarbital; Clinical Trials as Topic; Codeine; Humans; Pain; Postoperative Care; Scopo

1965

Other Studies

20 other studies available for amobarbital and Ache

ArticleYear
HPLC-UV Method Validation for Amobarbital and Pharmaceutical Stability Evaluation When Dispersed in a Hyaluronic Acid Hydrogel: A New Concept for Post-Traumatic Osteoarthritis Prevention.
    Journal of pharmaceutical sciences, 2022, Volume: 111, Issue:5

    Topics: Amobarbital; Chromatography, High Pressure Liquid; Humans; Hyaluronic Acid; Hydrogels; Osteoarthriti

2022
[Peculiarities of activity of narcotics following nociceptive irritation in hypothyroidism in animals].
    Biulleten' eksperimental'noi biologii i meditsiny, 1958, Volume: 46, Issue:7

    Topics: Amobarbital; Animals; Chloral Hydrate; Hypothyroidism; Narcotics; Pain; Skin Diseases; Thiouracil

1958
FEAR AND PAIN: THEIR EFFECT ON SELF-INJECTION OF AMOBARBITAL SODIUM BY RATS.
    Science (New York, N.Y.), 1963, Sep-27, Volume: 141, Issue:3587

    Topics: Amobarbital; Fear; Injections; Pain; Rats; Reinforcement, Psychology; Research

1963
[PAIN EXPERIENCE AND ITS CONTROL BY DRUGS].
    Die Medizinische Welt, 1965, Jan-16, Volume: 52

    Topics: Amobarbital; Codeine; Dimenhydrinate; Drug Therapy; Humans; Pain; Scopolamine

1965
Posttraumatic painful torticollis.
    Movement disorders : official journal of the Movement Disorder Society, 2003, Volume: 18, Issue:12

    Topics: Adolescent; Adult; Amobarbital; Female; Humans; Hypnotics and Sedatives; Injections, Intravenous; Ma

2003
A precise technique for the measurement of pain.
    Headache, 1967, Volume: 6, Issue:4

    Topics: Adult; Amobarbital; Female; Humans; Male; Pain

1967
[Gynecologic-obstetric pain therapy. Use of Lonarid N].
    ZFA. Zeitschrift fur Allgemeinmedizin, 1980, Feb-20, Volume: 56, Issue:5

    Topics: Acetaminophen; Adolescent; Adult; Amobarbital; Caffeine; Codeine; Drug Combinations; Dysmenorrhea; E

1980
Sodium amytal in the diagnosis of chronic pain.
    Canadian Psychiatric Association journal, 1978, Volume: 23, Issue:4

    Topics: Adult; Amobarbital; Chronic Disease; Female; Humans; Infusions, Parenteral; Male; Malingering; Middl

1978
[Initial treatment of colics and spastic pain].
    Medizinische Monatsschrift, 1977, Volume: 31, Issue:4

    Topics: Amobarbital; Butylscopolammonium Bromide; Codeine; Colic; Drug Combinations; Pain; Spasm

1977
Dexamyl, abdominal angina, and celiac-artery compression.
    Annals of internal medicine, 1977, Volume: 87, Issue:2

    Topics: Abdomen; Amobarbital; Celiac Artery; Dextroamphetamine; Drug Combinations; Female; Humans; Middle Ag

1977
[Rational and risk-free treatment of internal-medicine emergencies].
    Medizinische Monatsschrift, 1977, Volume: 31, Issue:7

    Topics: Ambulatory Care; Amobarbital; Codeine; Dipyrone; Drug Combinations; Emergencies; Gastrointestinal Di

1977
The pharmacology of 1,6-dimethyl-3-carbethoxy-4-oxo-6,7,8,9-tetrahydrohomopyrimidazol-methylsulphate (MZ-144), a new, potent, non-narcotic analgesic. II. Toxicity and analgetic effect of MZ-144 compared to narcotic and non-narcotic analgesics.
    Arzneimittel-Forschung, 1971, Volume: 21, Issue:5

    Topics: Aminopyrine; Amobarbital; Analgesics; Animals; Aspirin; Blood; Cats; Codeine; Diazepam; Dogs; Drug A

1971
The application of thymometry to the measurement of anxiety.
    International journal of neuropsychiatry, 1966, Volume: 2, Issue:4

    Topics: Amobarbital; Anxiety; Audiometry; Carbon Dioxide; Emotions; Humans; Nystagmus, Pathologic; Pain; Pro

1966
[Pain from the viewpoint of the general practitioner. Experiences with a new analgesic].
    Medizinische Monatsschrift, 1969, Volume: 23, Issue:8

    Topics: Adolescent; Adult; Aged; Amobarbital; Analgesics; Antipyrine; Caffeine; Family Practice; Humans; Mid

1969
[Ambulatory experiences with a new analgesic].
    Zeitschrift fur Allgemeinmedizin, 1969, Nov-20, Volume: 45, Issue:32

    Topics: Adult; Aged; Ambulatory Care; Aminopyrine; Amobarbital; Analgesics; Antipyrine; Caffeine; Female; Hu

1969
[Comments on analgetic therapy in urology].
    Die Medizinische Welt, 1968, Nov-09, Volume: 45

    Topics: Adolescent; Adult; Aged; Amobarbital; Analgesics; Codeine; Dimenhydrinate; Female; Humans; Male; Mid

1968
Anxiety and pain.
    JAMA, 1969, Aug-18, Volume: 209, Issue:7

    Topics: Amobarbital; Anxiety; Fear; Humans; Hysteria; Male; Military Medicine; Morphine; Pain; Time Factors;

1969
[Clinical experiences with a new morphine-sparing analgesic].
    Medizinische Monatsschrift, 1965, Volume: 19, Issue:11

    Topics: Aminopyrine; Amobarbital; Codeine; Humans; Pain; Scopolamine

1965
Pharmacological effects of some 6-azauracil derivatives.
    Biochemical pharmacology, 1966, Volume: 15, Issue:3

    Topics: Amobarbital; Animals; Blood Pressure; Body Temperature; Carotid Sinus; Diuresis; Dogs; Electroconvul

1966
[Drug therapy in control of pains in gynecology].
    Die Medizinische Welt, 1966, Jul-09, Volume: 28

    Topics: Amobarbital; Codeine; Dysmenorrhea; Female; Genital Diseases, Female; Humans; Pain; Postoperative Co

1966