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ammonium hydroxide and Pyruvate Dehydrogenase Complex Deficiency Disease

ammonium hydroxide has been researched along with Pyruvate Dehydrogenase Complex Deficiency Disease in 3 studies

azane : Saturated acyclic nitrogen hydrides having the general formula NnHn+2.

Pyruvate Dehydrogenase Complex Deficiency Disease: An inherited metabolic disorder caused by deficient enzyme activity in the PYRUVATE DEHYDROGENASE COMPLEX, resulting in deficiency of acetyl CoA and reduced synthesis of acetylcholine. Two clinical forms are recognized: neonatal and juvenile. The neonatal form is a relatively common cause of lactic acidosis in the first weeks of life and may also feature an erythematous rash. The juvenile form presents with lactic acidosis, alopecia, intermittent ATAXIA; SEIZURES; and an erythematous rash. (From J Inherit Metab Dis 1996;19(4):452-62) Autosomal recessive and X-linked forms are caused by mutations in the genes for the three different enzyme components of this multisubunit pyruvate dehydrogenase complex. One of the mutations at Xp22.2-p22.1 in the gene for the E1 alpha component of the complex leads to LEIGH DISEASE.

Research Excerpts

ExcerptRelevanceReference
"The patient lapsed into a coma shortly after birth with severe metabolic acidosis caused by accumulation of lactate and pyruvate."1.27Fatal case of pyruvate dehydrogenase deficiency. ( Koike, K; Koike, M; Matsuo, M; Ookita, K; Takemine, H, 1985)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19903 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Byrd, DJ1
Krohn, HP1
Winkler, L1
Steinborn, C1
Hadam, M1
Brodehl, J1
Hunneman, DH1
Brown, GK1
Scholem, RD1
Hunt, SM1
Harrison, JR1
Pollard, AC1
Matsuo, M1
Ookita, K1
Takemine, H1
Koike, K1
Koike, M1

Other Studies

3 other studies available for ammonium hydroxide and Pyruvate Dehydrogenase Complex Deficiency Disease

ArticleYear
Neonatal pyruvate dehydrogenase deficiency with lipoate responsive lactic acidaemia and hyperammonaemia.
    European journal of pediatrics, 1989, Volume: 148, Issue:6

    Topics: Acidosis, Lactic; Ammonia; Female; Humans; Infant, Newborn; Pyruvate Dehydrogenase Complex Deficienc

1989
Hyperammonaemia and lactic acidosis in a patient with pyruvate dehydrogenase deficiency.
    Journal of inherited metabolic disease, 1987, Volume: 10, Issue:4

    Topics: Acidosis, Lactic; Ammonia; Cells, Cultured; Female; Fibroblasts; Humans; Immunohistochemistry; Infan

1987
Fatal case of pyruvate dehydrogenase deficiency.
    Acta paediatrica Scandinavica, 1985, Volume: 74, Issue:1

    Topics: Acidosis; Ammonia; Coma; Humans; Infant, Newborn; Kidney; Liver; Male; Pyruvate Dehydrogenase Comple

1985