ammonium hydroxide has been researched along with Liver Failure in 96 studies
azane : Saturated acyclic nitrogen hydrides having the general formula NnHn+2.
Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Short-term administration of Galactosamine to experimental animals causes liver damage and acute liver failure (ALF), as well as acute renal failure in some cases." | 7.81 | D-Galactosamine Intoxication in Experimental Animals: Is it Only an Experimental Model of Acute Liver Failure? ( Brytan, M; Dyrla, P; Gil, J; Kade, G; Nowak, Z; Patera, J; Saracyn, M; Wańkowicz, Z; Zdanowski, R, 2015) |
| " The aim of the present study was to examine whether pyrrolidine dithiocarbamate (PDTC), an anti oxidant and inhibitor of NF-kappaB activation, would prevent hepatic damage induced in a rat model of thioacetamide (TAA)-induced liver failure." | 7.71 | Pyrrolidine dithiocarbamate protects against thioacetamide-induced fulminant hepatic failure in rats. ( Aeed, H; Avni, Y; Bruck, R; Hochman, A; Matas, Z; Reifen, R; Schey, R; Zaiger, G, 2002) |
| "Lovastatin is a 3-hydroxy-3-methylglutaryl CoA reductase inhibitor that inhibits cholesterol biosynthesis and affects the activity of some signal transduction pathways and liver transcription factors." | 5.31 | Lovastatin decreases mortality and improves liver functions in fulminant hepatic failure from 90% partial hepatectomy in rats. ( Cai, SR; Flye, MW; Kennedy, SC; Motoyama, K; Ponder, KP; Shen, KJ, 2000) |
| "By contrast, rats with hepatic encephalopathy (HE) following administration of a hepatotoxin, thioacetamide, were characterized by CC edema and an increased Tau content in both BG and CC." | 5.29 | Relation of taurine transport and brain edema in rats with simple hyperammonemia or liver failure. ( Albrecht, J; Hilgier, W; Olson, JE, 1996) |
| "Short-term administration of Galactosamine to experimental animals causes liver damage and acute liver failure (ALF), as well as acute renal failure in some cases." | 3.81 | D-Galactosamine Intoxication in Experimental Animals: Is it Only an Experimental Model of Acute Liver Failure? ( Brytan, M; Dyrla, P; Gil, J; Kade, G; Nowak, Z; Patera, J; Saracyn, M; Wańkowicz, Z; Zdanowski, R, 2015) |
| " Liver failure with significant increase in serum concentration of bilirubin, alanine transaminase (ALT) and ammonia, as well as huge microscopic necrosis of hepatocytes developed in both groups, but we did not achieved any evidence of acute renal failure in Wistar rats group." | 3.74 | [Race of experimental animals and development of renal failure in animal model of hepatorenal syndrome]. ( Kozłowski, W; Nowak, Z; Patera, J; Saracyn, M; Wańkowicz, Z; Wesołowski, P, 2008) |
| " plantarum strains were administered in ornithine transcarbamoylase-deficient Sparse-fur mice, a model of constitutive hyperammonemia, in a carbon tetrachloride rat model of chronic liver insufficiency and in a thioacetamide-induced acute liver failure mice model." | 3.74 | Control of acute, chronic, and constitutive hyperammonemia by wild-type and genetically engineered Lactobacillus plantarum in rodents. ( Demetter, P; Devière, J; Goffin, P; Gustot, T; Hols, P; Moreno, C; Nicaise, C; Prozzi, D; Quertinmont, E; Suain, V; Viaene, E, 2008) |
| " Liver failure developed with significant increase in serum concentration of bilirubin, AST, ALT; ammonia and massive necrosis of hepatocytes." | 3.72 | [Description of an experimental model of hepatorenal syndrome in Wistar rats]. ( Kozłowski, W; Saracyn, M; Wańikowicz, Z, 2004) |
| "The proposed discrimination methodology was applied to plasma and tissue (liver) metabolic profiling data describing the time progression of liver dysfunction in a rat model of acute hepatic failure generated by d-galactosamine (GalN) injection." | 3.72 | Identification of optimal classification functions for biological sample and state discrimination from metabolic profiling data. ( Hwang, D; Lee, K; Stephanopoulos, G; Stephanopoulos, GN; Yarmush, ML; Yokoyama, T, 2004) |
| " The aim of the present study was to examine whether pyrrolidine dithiocarbamate (PDTC), an anti oxidant and inhibitor of NF-kappaB activation, would prevent hepatic damage induced in a rat model of thioacetamide (TAA)-induced liver failure." | 3.71 | Pyrrolidine dithiocarbamate protects against thioacetamide-induced fulminant hepatic failure in rats. ( Aeed, H; Avni, Y; Bruck, R; Hochman, A; Matas, Z; Reifen, R; Schey, R; Zaiger, G, 2002) |
| "Portocaval shunt with common bile duct transection produces liver failure with elevations in aminotransferases, total bilirubin, and ammonia, a decreased branched chain to aromatic amino acid ratio, and histologic inflammation." | 3.70 | A novel stable reproducible model of hepatic failure in canines. ( Awad, SS; Bartlett, RH; Gargulinski, M; Hemmila, MR; Hirschl, RB; Mahler, S; Rich, PB; Sawada, S; Soldes, OS, 2000) |
| "Renal glutamine uptake and subsequent urinary ammonia excretion could be an important alternative pathway of ammonia disposal from the body during liver failure (diminished urea synthesis), but this pathway has received little attention." | 3.68 | Renal ammonia and glutamine metabolism during liver insufficiency-induced hyperammonemia in the rat. ( Dejong, CH; Deutz, NE; Soeters, PB, 1993) |
| "Acute liver failure (ALF) as a result of mushroom poisoning is associated with a high mortality (particularly in children), despite optimal medical therapy (OMT), including charcoal haemoperfusion and haemodiafiltration." | 2.71 | Successful use of Molecular Absorbent Regenerating System (MARS) dialysis for the treatment of fulminant hepatic failure in children accidentally poisoned by toxic mushroom ingestion. ( Bizo, A; Covic, A; Cristogel, F; Dimitriu, AG; Goldsmith, DJ; Gusbeth-Tatomir, P; Volovat, C, 2003) |
| "Infection and inflammation have been associated with the development of delirium for many centuries and there is a rapidly growing evidence base supporting the role of inflammation in exacerbating the neurological manifestations of both acute and chronic liver failure." | 2.49 | Systemic inflammation and ammonia in hepatic encephalopathy. ( Ryan, JM; Shawcross, DL; Tranah, TH; Vijay, GK, 2013) |
| "Hepatic encephalopathy is a neuropsychiatric syndrome associated with liver failure." | 2.47 | To pee or not to pee: ammonia hypothesis of hepatic encephalopathy revisited. ( Dejong, CH; Jalan, R; Mpabanzi, L; Olde Damink, SW; Soeters, PB; van de Poll, MC, 2011) |
| "Introduction." | 2.47 | Critical analysis of studies evaluating the efficacy of infusion of L-ornithine L-aspartate in clinical hepatic encephalopathy in patients with liver failure. ( Abdo Francis, JM; Higuera de la Tijera, F; Pérez Hernández, JL; Serralde-Zúñiga, AE, 2011) |
| "Subclinical hepatic encephalopathy (SHE) is a serious clinical problem in patiens with liver damage and precise pathophisiological mechanisms resonsible for encephalopathy are not fully understood." | 2.46 | [Pathogenesis and diagnosis of subclinical hepatic encephalopathy]. ( Ciećko-Michalska, I; Mach, T; Słowik, A, 2010) |
| "Liver failure is associated with hepatic encephalopathy (HE)." | 2.44 | Aromatic amino acid metabolism during liver failure. ( Dejong, CH; Jalan, R; Olde Damink, SW; Soeters, PB; van de Poll, MC, 2007) |
| "Fulminant hepatic failure is a life-threatening clinical syndrome following severe hepatic injury leading to cerebral edema and brainstem herniation." | 2.41 | Extracorporeal treatment in fulminant hepatic failure: pathophysiologic considerations. ( Bauer, E; Kramer, L, 2002) |
| "Hepatic encephalopathy is considered to be a reversible metabolic encephalopathy, which occurs as a complication of hepatocellular failure and is associated with increased portal-systemic shunting of gut-derived nitrogenous compounds." | 2.41 | Pathogenesis of hepatic encephalopathy. ( Jones, EA, 2000) |
| "Acute liver failure was present in 4 (25%) and acute-on-chronic liver failure in 8 (75%)." | 1.72 | Ammonia Clearance with Different Continuous Renal Replacement Therapy Techniques in Patients with Liver Failure. ( Baldwin, I; Bellomo, R; Fealy, N; Fisher, C; Naorungroj, T, 2022) |
| "Liver failure is characterized by accumulation of potentially toxic substances in the systemic circulation of the patient." | 1.51 | Impact of Cytokine Adsorption Treatment in Liver Failure. ( Acar, U; Açık, ME; Akbulut, A; Ferah, O; Gökkaya, Z; Tokat, Y; Yenidünya, Ö; Yentür, E, 2019) |
| "In patients with hepatic encephalopathy (HE) the blood concentration of ammonia is usually highly elevated." | 1.35 | Backflux of ammonia from brain to blood in human subjects with and without hepatic encephalopathy. ( Keiding, S; Munk, OL; Sørensen, M, 2009) |
| "An atypical form of parkinsonism has been described in patients with chronic liver disease, associated with increased T1 signal in the basal ganglia on magnetic resonance imaging." | 1.33 | Neurologic spectrum of chronic liver failure and basal ganglia T1 hyperintensity on magnetic resonance imaging: probable manganese neurotoxicity. ( Ahlskog, JE; Cowl, CT; Fealey, RD; Josephs, KA; Klos, KJ; Kumar, N, 2005) |
| "The cause of liver failure included acute liver failure (n = 2), acute on chronic liver failure (n = 12), posthepatectomy liver failure (n = 4), and posttransplantation allograft failure (n = 4)." | 1.33 | Molecular adsorbent recirculating system treatment for patients with liver failure: the Hong Kong experience. ( Chan, LM; Chiu, A; Fan, ST, 2006) |
| "The correlation with the severity of hepatic encephalopathy was similar for venous (r=0." | 1.32 | Role of determination of partial pressure of ammonia in cirrhotic patients with and without hepatic encephalopathy. ( Attili, AF; Efrati, C; Masini, A; Merli, M; Nicolao, F; Riggio, O, 2003) |
| "Lovastatin is a 3-hydroxy-3-methylglutaryl CoA reductase inhibitor that inhibits cholesterol biosynthesis and affects the activity of some signal transduction pathways and liver transcription factors." | 1.31 | Lovastatin decreases mortality and improves liver functions in fulminant hepatic failure from 90% partial hepatectomy in rats. ( Cai, SR; Flye, MW; Kennedy, SC; Motoyama, K; Ponder, KP; Shen, KJ, 2000) |
| "An acute confusional state occurred in more than half the patients with transplantation for alcoholic liver disease." | 1.31 | Acute confusional state following liver transplantation for alcoholic liver disease. ( Buis, CI; Kremers, WK; Krom, RA; Wiesner, RH; Wijdicks, EF, 2002) |
| "Acute hepatic failure was induced by end-to-side portocaval shunt and ligature of the whole porta hepatitis." | 1.31 | Reduced encephalopathy in pigs with ischemia-induced acute hepatic failure treated with a bioartificial liver containing alginate-entrapped hepatocytes. ( Bouix, A; Campion, JP; Clément, B; Desbois, J; Desille, M; Desjardins, JF; Frémond, B; Joly, A; Lebreton, Y; Mahler, S; Mallédant, Y; Sébille, V; Seguin, P, 2002) |
| "Cerebral edema leading to cerebral herniation (CH) is a common cause of death in acute liver failure (ALF)." | 1.30 | Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration. ( Clemmesen, JO; Hansen, BA; Kondrup, J; Larsen, FS; Ott, P, 1999) |
| "Acute liver failure was induced by a two-stage devascularization procedure." | 1.29 | Neuronal and glial marker proteins in encephalopathy associated with acute liver failure and acute hyperammonemia in the rabbit. ( de Knegt, RJ; Ding, M; Groeneweg, M; Haglid, KG; Hamberger, A; Schalm, SW; Wang, S, 1993) |
| "Hepatic encephalopathy was induced by a two-stage liver devascularization procedure and acute hyperammonemia by a prolonged ammonium-acetate infusion; rabbits receiving a sodium-potassium-acetate infusion served as controls." | 1.29 | Binding of the ligand [3H]MK-801 to the MK-801 binding site of the N-methyl-D-aspartate receptor during experimental encephalopathy from acute liver failure and from acute hyperammonemia in the rabbit. ( de Knegt, RJ; Kornhuber, J; Riederer, P; Rusche, K; Schalm, SW; Tan, J, 1993) |
| "By contrast, rats with hepatic encephalopathy (HE) following administration of a hepatotoxin, thioacetamide, were characterized by CC edema and an increased Tau content in both BG and CC." | 1.29 | Relation of taurine transport and brain edema in rats with simple hyperammonemia or liver failure. ( Albrecht, J; Hilgier, W; Olson, JE, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (3.13) | 18.7374 |
| 1990's | 21 (21.88) | 18.2507 |
| 2000's | 51 (53.13) | 29.6817 |
| 2010's | 15 (15.63) | 24.3611 |
| 2020's | 6 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Fisher, C | 1 |
| Baldwin, I | 1 |
| Fealy, N | 1 |
| Naorungroj, T | 1 |
| Bellomo, R | 1 |
| Zhao, L | 1 |
| Hou, S | 1 |
| Na, R | 1 |
| Liu, B | 1 |
| Wang, Z | 1 |
| Li, Y | 1 |
| Xie, K | 1 |
| Liebchen, U | 1 |
| Paal, M | 1 |
| Gräfe, C | 1 |
| Zoller, M | 1 |
| Scharf, C | 1 |
| Lu, K | 1 |
| Sommerfeld, O | 1 |
| Neumann, C | 1 |
| Becker, J | 1 |
| von Loeffelholz, C | 1 |
| Roth, J | 1 |
| Kortgen, A | 1 |
| Bauer, M | 1 |
| Sponholz, C | 1 |
| Acar, U | 1 |
| Gökkaya, Z | 1 |
| Akbulut, A | 1 |
| Ferah, O | 1 |
| Yenidünya, Ö | 1 |
| Açık, ME | 1 |
| Tokat, Y | 1 |
| Yentür, E | 1 |
| Honore, PM | 1 |
| Barreto Gutierrez, L | 1 |
| Kugener, L | 1 |
| Redant, S | 1 |
| Attou, R | 1 |
| Gallerani, A | 1 |
| De Bels, D | 1 |
| Stenbøg, P | 1 |
| Busk, T | 1 |
| Larsen, FS | 5 |
| Slack, AJ | 1 |
| Auzinger, G | 1 |
| Willars, C | 1 |
| Dew, T | 1 |
| Musto, R | 1 |
| Corsilli, D | 1 |
| Sherwood, R | 1 |
| Wendon, JA | 1 |
| Bernal, W | 1 |
| Wang, XQ | 1 |
| Tang, NH | 1 |
| Zhang, FY | 1 |
| Li, XJ | 1 |
| Chen, YL | 1 |
| Rama Rao, KV | 1 |
| Jayakumar, AR | 1 |
| Norenberg, MD | 1 |
| Saracyn, M | 3 |
| Zdanowski, R | 1 |
| Brytan, M | 1 |
| Kade, G | 1 |
| Nowak, Z | 2 |
| Patera, J | 2 |
| Dyrla, P | 1 |
| Gil, J | 1 |
| Wańkowicz, Z | 2 |
| Sussman, NL | 1 |
| Kristiansen, RG | 1 |
| Wesołowski, P | 1 |
| Kozłowski, W | 2 |
| Nicaise, C | 1 |
| Prozzi, D | 1 |
| Viaene, E | 1 |
| Moreno, C | 1 |
| Gustot, T | 1 |
| Quertinmont, E | 1 |
| Demetter, P | 1 |
| Suain, V | 1 |
| Goffin, P | 1 |
| Devière, J | 1 |
| Hols, P | 1 |
| Butterworth, RF | 6 |
| Sørensen, M | 1 |
| Munk, OL | 1 |
| Keiding, S | 1 |
| Rifai, K | 1 |
| Das, A | 1 |
| Rosenau, J | 1 |
| Ernst, T | 1 |
| Kretschmer, U | 1 |
| Haller, H | 1 |
| Fliser, D | 1 |
| Manns, MP | 1 |
| Coward, SM | 1 |
| Legallais, C | 1 |
| David, B | 1 |
| Thomas, M | 1 |
| Foo, Y | 1 |
| Mavri-Damelin, D | 1 |
| Hodgson, HJ | 1 |
| Selden, C | 1 |
| Ciećko-Michalska, I | 1 |
| Mach, T | 1 |
| Słowik, A | 1 |
| Wright, G | 1 |
| Noiret, L | 1 |
| Olde Damink, SW | 3 |
| Jalan, R | 3 |
| Mpabanzi, L | 1 |
| van de Poll, MC | 2 |
| Soeters, PB | 6 |
| Dejong, CH | 6 |
| Hoekstra, R | 1 |
| Nibourg, GA | 1 |
| van der Hoeven, TV | 1 |
| Ackermans, MT | 1 |
| Hakvoort, TB | 1 |
| van Gulik, TM | 2 |
| Lamers, WH | 1 |
| Elferink, RP | 1 |
| Chamuleau, RA | 2 |
| Pérez Hernández, JL | 1 |
| Higuera de la Tijera, F | 1 |
| Serralde-Zúñiga, AE | 1 |
| Abdo Francis, JM | 1 |
| Tranah, TH | 1 |
| Vijay, GK | 1 |
| Ryan, JM | 1 |
| Shawcross, DL | 1 |
| Wang, X | 2 |
| Zhou, X | 1 |
| Miao, J | 1 |
| Fan, D | 1 |
| Yamashita, Y | 3 |
| Shimada, M | 4 |
| Tsujita, E | 3 |
| Shirabe, K | 3 |
| Ijima, H | 5 |
| Nakazawa, K | 5 |
| Sakiyama, R | 4 |
| Fukuda, J | 3 |
| Funatsu, K | 5 |
| Sugimachi, K | 4 |
| Buis, CI | 1 |
| Wiesner, RH | 1 |
| Krom, RA | 1 |
| Kremers, WK | 1 |
| Wijdicks, EF | 1 |
| Chen, S | 1 |
| Zhang, L | 1 |
| Shi, Y | 1 |
| Yang, X | 1 |
| Wang, M | 1 |
| Córdoba, J | 1 |
| Kramer, L | 1 |
| Bauer, E | 1 |
| Mizumoto, H | 1 |
| Kajiwara, T | 1 |
| Ito, M | 2 |
| Ishibashi, H | 1 |
| Nicolao, F | 1 |
| Efrati, C | 1 |
| Masini, A | 1 |
| Merli, M | 1 |
| Attili, AF | 1 |
| Riggio, O | 1 |
| Naruse, K | 3 |
| Sakai, Y | 3 |
| Natori, T | 1 |
| Guo, L | 1 |
| Shindoh, J | 2 |
| Iida, Y | 1 |
| Michishita, K | 1 |
| Karasawa, Y | 1 |
| Kojima, K | 1 |
| Makuuchi, M | 3 |
| Covic, A | 1 |
| Goldsmith, DJ | 1 |
| Gusbeth-Tatomir, P | 1 |
| Volovat, C | 1 |
| Dimitriu, AG | 1 |
| Cristogel, F | 1 |
| Bizo, A | 1 |
| DRAPANAS, T | 1 |
| BECKER, DR | 1 |
| SCHENK, WG | 1 |
| SHAW, WW | 1 |
| POTTER, WH | 1 |
| STEWART, JD | 1 |
| MOORE, EW | 1 |
| STROHMEYER, GW | 1 |
| CHALMERS, TC | 1 |
| RITCHIE, HD | 1 |
| Sun, T | 1 |
| Chan, ML | 1 |
| Zhou, Y | 1 |
| Xu, X | 1 |
| Zhang, J | 1 |
| Lao, X | 1 |
| Quek, CH | 1 |
| Chen, JP | 1 |
| Leong, KW | 1 |
| Yu, H | 1 |
| Ott, P | 2 |
| Lee, K | 1 |
| Hwang, D | 1 |
| Yokoyama, T | 1 |
| Stephanopoulos, G | 1 |
| Stephanopoulos, GN | 1 |
| Yarmush, ML | 1 |
| Wańikowicz, Z | 1 |
| Kundra, A | 1 |
| Jain, A | 1 |
| Banga, A | 1 |
| Bajaj, G | 1 |
| Kar, P | 1 |
| Klos, KJ | 1 |
| Ahlskog, JE | 1 |
| Josephs, KA | 1 |
| Fealey, RD | 1 |
| Cowl, CT | 1 |
| Kumar, N | 1 |
| Stefoni, S | 1 |
| Colì, L | 1 |
| Bolondi, L | 1 |
| Donati, G | 2 |
| Ruggeri, G | 1 |
| Feliciangeli, G | 1 |
| Piscaglia, F | 1 |
| Silvagni, E | 1 |
| Sirri, M | 1 |
| Baraldi, O | 1 |
| Soverini, ML | 1 |
| Cianciolo, G | 1 |
| Boni, P | 1 |
| Patrono, D | 1 |
| Ramazzotti, E | 1 |
| Motta, R | 1 |
| Roda, A | 1 |
| Simoni, P | 1 |
| Magliulo, M | 1 |
| Borgnino, LC | 1 |
| Ricci, D | 1 |
| Mezzopane, D | 1 |
| Cappuccilli, ML | 1 |
| Evenepoel, P | 1 |
| Laleman, W | 1 |
| Wilmer, A | 1 |
| Claes, K | 1 |
| Kuypers, D | 1 |
| Bammens, B | 1 |
| Nevens, F | 1 |
| Vanrenterghem, Y | 1 |
| Chiu, A | 1 |
| Chan, LM | 1 |
| Fan, ST | 1 |
| Rodrigo, R | 1 |
| Erceg, S | 1 |
| Rodriguez-Diaz, J | 1 |
| Saez-Valero, J | 1 |
| Piedrafita, B | 1 |
| Suarez, I | 1 |
| Felipo, V | 1 |
| Ytrebø, LM | 1 |
| Wolff, B | 1 |
| Machill, K | 1 |
| Schumacher, D | 1 |
| Schulzki, I | 1 |
| Eckhoff, DE | 1 |
| Pirsch, JD | 1 |
| D'Alessandro, AM | 1 |
| Knechtle, SJ | 1 |
| Young, CJ | 1 |
| Geffner, SR | 1 |
| Belzer, FO | 1 |
| Kalayoglu, M | 1 |
| Deutz, NE | 4 |
| Nishikawa, Y | 1 |
| Ukida, M | 1 |
| Matsuo, R | 1 |
| Morimoto, Y | 1 |
| Omori, N | 1 |
| Mikami, M | 1 |
| Tsuji, T | 1 |
| Koebe, HG | 1 |
| Thasler, W | 1 |
| Schildberg, FW | 1 |
| Groeneweg, M | 1 |
| de Knegt, RJ | 2 |
| Hamberger, A | 1 |
| Ding, M | 1 |
| Wang, S | 1 |
| Schalm, SW | 2 |
| Haglid, KG | 1 |
| Kornhuber, J | 1 |
| Rusche, K | 1 |
| Riederer, P | 1 |
| Tan, J | 1 |
| Hilgier, W | 1 |
| Olson, JE | 1 |
| Albrecht, J | 1 |
| Jones, EA | 3 |
| Basile, AS | 2 |
| Fujii, S | 1 |
| Fukuda, S | 1 |
| Sezaki, T | 1 |
| Murakami, M | 1 |
| Nagashima, I | 1 |
| Harihara, Y | 1 |
| Jiang, GX | 1 |
| Suzuki, M | 1 |
| Muto, T | 1 |
| Clemmesen, JO | 1 |
| Kondrup, J | 2 |
| Hansen, BA | 2 |
| Gion, T | 1 |
| Matsushita, T | 1 |
| Mizock, BA | 1 |
| Stange, J | 1 |
| Mitzner, SR | 1 |
| Risler, T | 1 |
| Erley, CM | 1 |
| Lauchart, W | 1 |
| Goehl, H | 1 |
| Klammt, S | 1 |
| Peszynski, P | 1 |
| Freytag, J | 1 |
| Hickstein, H | 1 |
| Löhr, M | 1 |
| Liebe, S | 1 |
| Schareck, W | 1 |
| Hopt, UT | 1 |
| Schmidt, R | 1 |
| Fujioka, H | 2 |
| Eguchi, S | 2 |
| Sugiyama, N | 1 |
| Kawazoe, Y | 2 |
| Kawashita, Y | 2 |
| Kamohara, Y | 2 |
| Azuma, T | 2 |
| Furui, J | 2 |
| Kanematsu, T | 2 |
| Benoist, S | 1 |
| Sarkis, R | 1 |
| Baudrimont, M | 1 |
| Delelo, R | 1 |
| Robert, A | 1 |
| Vaubourdolle, M | 1 |
| Balladur, P | 1 |
| Calmus, Y | 1 |
| Capeau, J | 1 |
| Nordlinger, B | 1 |
| Cai, SR | 1 |
| Motoyama, K | 1 |
| Shen, KJ | 1 |
| Kennedy, SC | 1 |
| Flye, MW | 1 |
| Ponder, KP | 1 |
| Desjardins, P | 1 |
| Rao, KV | 1 |
| Michalak, A | 2 |
| Rose, C | 2 |
| Kobayashi, N | 2 |
| Noguchi, H | 1 |
| Fujiwara, T | 1 |
| Tanaka, N | 1 |
| Takeuchi, H | 1 |
| Tomizawa, M | 1 |
| Miyamoto, T | 1 |
| Kato, H | 1 |
| Otsu, H | 1 |
| Awad, SS | 1 |
| Hemmila, MR | 1 |
| Soldes, OS | 1 |
| Sawada, S | 1 |
| Rich, PB | 1 |
| Mahler, S | 2 |
| Gargulinski, M | 1 |
| Hirschl, RB | 1 |
| Bartlett, RH | 1 |
| Nakamura, J | 1 |
| Cai, J | 1 |
| Cao, C | 1 |
| Hammel, JM | 1 |
| Fox, IJ | 1 |
| Tsutsumi, R | 1 |
| Miyamoto, S | 1 |
| Moriuchi, H | 1 |
| Tamura, T | 1 |
| Rikimaru, T | 1 |
| Schmidt, LE | 1 |
| Svendsen, LB | 1 |
| Sørensen, VR | 1 |
| Enosawa, S | 1 |
| Miyashita, T | 1 |
| Fujita, Y | 1 |
| Suzuki, S | 1 |
| Amemiya, H | 1 |
| Omasa, T | 1 |
| Hiramatsu, S | 1 |
| Suga, K | 1 |
| Matsumura, T | 1 |
| Strauss, GI | 1 |
| Knudsen, GM | 1 |
| Møller, K | 1 |
| Sosef, MN | 1 |
| Abrahamse, LS | 1 |
| van de Kerkhove, MP | 1 |
| Hartman, R | 1 |
| Bruck, R | 1 |
| Aeed, H | 1 |
| Schey, R | 1 |
| Matas, Z | 1 |
| Reifen, R | 1 |
| Zaiger, G | 1 |
| Hochman, A | 1 |
| Avni, Y | 1 |
| Mora, N | 1 |
| Kaptanoglu, L | 1 |
| Zhang, Z | 1 |
| Niekrasz, M | 1 |
| Black, S | 1 |
| Ver Steeg, K | 1 |
| Wade, R | 1 |
| Siddall, V | 1 |
| Pao, W | 1 |
| Walsh, W | 1 |
| Ivancic, D | 1 |
| Kaufman, D | 1 |
| Abecassis, M | 1 |
| Stuart, F | 1 |
| Blei, A | 1 |
| Leventhal, J | 1 |
| Fryer, J | 1 |
| Desille, M | 1 |
| Seguin, P | 1 |
| Mallédant, Y | 1 |
| Frémond, B | 1 |
| Sébille, V | 1 |
| Bouix, A | 1 |
| Desjardins, JF | 1 |
| Joly, A | 1 |
| Desbois, J | 1 |
| Lebreton, Y | 1 |
| Campion, JP | 1 |
| Clément, B | 1 |
| Magarlamov, AG | 1 |
| Levchenko, IV | 1 |
| Anoshina, MIu | 1 |
| Ishchuk, OE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure: A Double- Blind, Randomized, Placebo- Controlled Study[NCT00470314] | Phase 2 | 150 participants (Actual) | Interventional | 2005-01-31 | Active, not recruiting | ||
| A Phase 2a Study to Evaluate the Safety and Tolerability of OCR-002 (Ornithine Phenylacetate) in the Treatment of Patients With Acute Liver Failure/Severe Acute Liver Injury[NCT01548690] | Phase 2 | 47 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
To evaluate the effect of OCR-002 on ammonia levels in patients with acute liver failure/severe acute liver injury (NCT01548690)
Timeframe: Baseline and 72 Hours
| Intervention | Percent Change (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 41.2 |
| Maximum Dose Level 6.65 g/24h | 16.6 |
| Maximum Dose Level 10 g/24h | 41.8 |
| Maximum Dose Level 20g/24h | 38.4 |
To evaluate the steady state pharmacokinetic and pharmacodynamic profile of OCR-002 in patients with impaired and intact renal function using urinary phenylacetylglutamine (PAGN) as a surrogate marker (NCT01548690)
Timeframe: 24 Hours after last infusion
| Intervention | micrograms per millileter (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 65.6 |
| Maximum Dose Level 6.65 g/24h | 32.2 |
| Maximum Dose Level 10 g/24h | 33.4 |
| Maximum Dose Level 20g/24h | 104.9 |
The orientation log focuses on orientation to place, time, and circumstance. There are 10 items on the orientation log, which are scored 0-3. A spontaneous correct response is awarded 3 points. A spontaneous response that is lacking or incorrect, but a correct response is provided following a logical cue is awarded 2 points. A score of 1 is given if spontaneous and cued responses are lacking or incorrect, but a correct response is provided in a recognition format. A score of 0 is given if the spontaneous, cued, or recognition format does not generate a correct answer. Scores from the 10 items are summed and the final score ranges from 0 to 30. (NCT01548690)
Timeframe: 30 Days
| Intervention | units on a scale (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 23.8 |
| Maximum Dose Level 6.65 g/24h | 24.0 |
| Maximum Dose Level 10 g/24h | 24.0 |
| Maximum Dose Level 20g/24h | 24.0 |
The West Haven Criteria (WHC) for Hepatic Encephalopathy measures the severity of encephalopathy and patient's level of consciousness. The scale ranges from 0 to 4; a minimum score of 0 represents a better outcome, and a maximum total score of 4 represents a worse outcome. A score of 0 corresponds to normal consciousness and behavior and normal neurological examination. A score of 1 corresponds to mild lack of awareness, shortened attention span, and impaired addition or subtraction; mild asterixis or tremor. A score of 2 corresponds to lethargy, disorientated or inappropriate behavior, obvious asterixis; slurred speech. A score of 3 corresponds to somnolent but arousable, gross disorientation or bizarre behavior, muscle rigidity and clonus; hyperreflexia. A score of 4 corresponds to coma and decerebrate posturing. (NCT01548690)
Timeframe: 120 hours from start of infusion
| Intervention | units on a scale (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 2.4 |
| Maximum Dose Level 6.65 g/24h | 3.2 |
| Maximum Dose Level 10 g/24h | 1.6 |
| Maximum Dose Level 20g/24h | 1.8 |
To evaluate the safety and tolerability of OCR-002 in patients with acute liver failure/severe acute liver injury (NCT01548690)
Timeframe: 30 Days
| Intervention | Participants (Count of Participants) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 0 |
| Maximum Dose Level 6.65 g/24h | 0 |
| Maximum Dose Level 10 g/24h | 0 |
| Maximum Dose Level 20g/24h | 0 |
25 reviews available for ammonium hydroxide and Liver Failure
| Article | Year |
|---|---|
Cellular Pathogenesis of Hepatic Encephalopathy: An Update.
Topics: Ammonia; Autophagy; Hepatic Encephalopathy; Humans; Hyperammonemia; Liver Failure | 2023 |
Efficacy of liver assisting in patients with hepatic encephalopathy with special focus on plasma exchange.
Topics: Ammonia; Chemical and Drug Induced Liver Injury; Hepatic Encephalopathy; Humans; Liver Failure; Live | 2013 |
Brain edema in acute liver failure: mechanisms and concepts.
Topics: Acute Disease; Ammonia; Animals; Astrocytes; Body Water; Brain Edema; Cell Size; Confounding Factors | 2014 |
Treatment of Overt Hepatic Encephalopathy.
Topics: Amino Acids, Branched-Chain; Ammonia; Arteriovenous Fistula; Dipeptides; Gastrointestinal Agents; Gl | 2015 |
Current state of knowledge of hepatic encephalopathy (part I): newer treatment strategies for hyperammonemia in liver failure.
Topics: Ammonia; Animals; Glutamate-Ammonia Ligase; Health Knowledge, Attitudes, Practice; Hepatic Encephalo | 2016 |
Thiamine deficiency-related brain dysfunction in chronic liver failure.
Topics: Adult; Aged; Ammonia; Brain; Chronic Disease; Encephalitis; Female; Hepatic Encephalopathy; Humans; | 2009 |
[Pathogenesis and diagnosis of subclinical hepatic encephalopathy].
Topics: Ammonia; Brain; Brain Edema; Hepatic Encephalopathy; Humans; Liver Failure; Neuropsychological Tests | 2010 |
Interorgan ammonia metabolism in liver failure: the basis of current and future therapies.
Topics: Adipose Tissue; Amino Acids; Ammonia; Arginine; Brain; Dipeptides; Glutamate-Ammonia Ligase; Glutami | 2011 |
To pee or not to pee: ammonia hypothesis of hepatic encephalopathy revisited.
Topics: Ammonia; Animals; Brain; Hepatic Encephalopathy; Humans; Intestinal Mucosa; Kidney; Liver; Liver Fai | 2011 |
Critical analysis of studies evaluating the efficacy of infusion of L-ornithine L-aspartate in clinical hepatic encephalopathy in patients with liver failure.
Topics: Adult; Aged; Ammonia; Dipeptides; Hepatic Encephalopathy; Humans; Infusions, Intravenous; Liver Fail | 2011 |
Systemic inflammation and ammonia in hepatic encephalopathy.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Immunity, Innate; Inflammation; Liver Failure; Systemic Inf | 2013 |
Extracorporeal treatment in fulminant hepatic failure: pathophysiologic considerations.
Topics: Ammonia; Animals; Brain Edema; Cerebrovascular Circulation; Glutamine; Hepatic Encephalopathy; Human | 2002 |
Pathophysiology of hepatic encephalopathy: a new look at ammonia.
Topics: Ammonia; Brain; Hepatic Encephalopathy; Humans; Liver Failure | 2002 |
Blood-brain barrier permeability to ammonia in liver failure: a critical reappraisal.
Topics: Ammonia; Animals; Blood-Brain Barrier; Brain; Cerebrovascular Circulation; Humans; Hydrogen-Ion Conc | 2004 |
Pathogenesis of hepatic encephalopathy: update on molecular mechanisms.
Topics: Ammonia; Brain; Chronic Disease; Diagnostic Imaging; Hepatic Encephalopathy; Humans; Liver Failure; | 2003 |
Aromatic amino acid metabolism during liver failure.
Topics: Amino Acids, Aromatic; Ammonia; Biological Transport; Humans; Liver Failure; Phenylalanine; Referenc | 2007 |
[Disturbances in ammonia metabolism in hepatic failure].
Topics: Ammonia; Animals; Brain; Hepatic Encephalopathy; Humans; Hyperammonemia; Intestinal Mucosa; Kidney; | 2007 |
[Bio-artificial organ replacement of the liver].
Topics: Ammonia; Animals; Artificial Organs; Bioprosthesis; Cells, Cultured; Dogs; Extracorporeal Circulatio | 1993 |
The involvement of ammonia with the mechanisms that enhance GABA-ergic neurotransmission in hepatic failure.
Topics: Ammonia; Animals; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Liver Failure; Synaptic T | 1997 |
[Clinicopathological study of multiple myeloma associated with hyperammonemia].
Topics: Aged; Aged, 80 and over; Amino Acids; Ammonia; Female; Humans; Liver; Liver Failure; Male; Middle Ag | 1998 |
Nutritional support in hepatic encephalopathy.
Topics: Amino Acids; Ammonia; Carbohydrate Metabolism; Dietary Proteins; Hepatic Encephalopathy; Humans; Lip | 1999 |
Does ammonia contribute to increased GABA-ergic neurotransmission in liver failure?
Topics: Ammonia; Animals; Behavior, Animal; Electrophysiology; gamma-Aminobutyric Acid; Humans; Liver Failur | 1998 |
The astrocytic ("peripheral-type") benzodiazepine receptor: role in the pathogenesis of portal-systemic encephalopathy.
Topics: Ammonia; Animals; Astrocytes; Chronic Disease; Hepatic Encephalopathy; Humans; Liver Failure; Mangan | 2000 |
[Hepatic encephalopathy [acute type, chronic/recurrent type and mixed/terminal coma type]].
Topics: Amino Acids, Branched-Chain; Ammonia; Diagnosis, Differential; Hepatic Encephalopathy; Humans; Liver | 2000 |
Pathogenesis of hepatic encephalopathy.
Topics: Ammonia; gamma-Aminobutyric Acid; Glutamic Acid; Hepatic Encephalopathy; Humans; Liver Failure; Rece | 2000 |
2 trials available for ammonium hydroxide and Liver Failure
| Article | Year |
|---|---|
Molecular Adsorbent Recirculating System: clinical experience in patients with liver failure based on hepatitis B in China.
Topics: Ammonia; Bilirubin; China; Creatinine; Hemoglobins; Hepatic Encephalopathy; Hepatitis B; Humans; Liv | 2002 |
Successful use of Molecular Absorbent Regenerating System (MARS) dialysis for the treatment of fulminant hepatic failure in children accidentally poisoned by toxic mushroom ingestion.
Topics: Adolescent; Alanine Transaminase; Amanita; Ammonia; Bilirubin; Child; Female; Glasgow Coma Scale; Hu | 2003 |
69 other studies available for ammonium hydroxide and Liver Failure
| Article | Year |
|---|---|
Ammonia Clearance with Different Continuous Renal Replacement Therapy Techniques in Patients with Liver Failure.
Topics: Acute Kidney Injury; Adult; Ammonia; Continuous Renal Replacement Therapy; Creatinine; Humans; Hyper | 2022 |
Prognostic role of serum ammonia in patients with sepsis-associated encephalopathy without hepatic failure.
Topics: Ammonia; Humans; Lactates; Liver Failure; Prognosis; Retrospective Studies; Sepsis-Associated Enceph | 2022 |
The cytokine adsorber Cytosorb® does not reduce ammonia concentrations in critically ill patients with liver failure.
Topics: Ammonia; Critical Illness; Cytokines; Hemoperfusion; Humans; Liver Failure | 2023 |
Extracorporeal albumin dialysis in critically ill patients with liver failure: Comparison of four different devices-A retrospective analysis.
Topics: Albumins; Ammonia; Bilirubin; Critical Illness; Humans; Liver Failure; Prospective Studies; Renal Di | 2023 |
Impact of Cytokine Adsorption Treatment in Liver Failure.
Topics: Adsorption; Ammonia; Bilirubin; Continuous Renal Replacement Therapy; Cytokines; Female; Humans; Hyp | 2019 |
Liver injury without liver failure in COVID-19 patients: how to explain, in some cases, elevated ammonia without hepatic decompensation.
Topics: Ammonia; Betacoronavirus; Coronavirus Infections; COVID-19; Critical Illness; Humans; Liver Failure; | 2020 |
Ammonia clearance with haemofiltration in adults with liver disease.
Topics: Adult; Ammonia; Female; Hemodiafiltration; Humans; Hyperammonemia; Liver Failure; Male; Middle Aged; | 2014 |
Therapeutic evaluation of a microbioartificial liver with recombinant HepG2 cells for rats with hepatic failure.
Topics: Ammonia; Animals; Arginase; Bioreactors; Galactosamine; Hep G2 Cells; Humans; Implants, Experimental | 2013 |
D-Galactosamine Intoxication in Experimental Animals: Is it Only an Experimental Model of Acute Liver Failure?
Topics: Acute Kidney Injury; Alanine Transaminase; Albumins; Ammonia; Animals; Aspartate Aminotransferases; | 2015 |
[Race of experimental animals and development of renal failure in animal model of hepatorenal syndrome].
Topics: Alanine Transaminase; Ammonia; Animals; Bilirubin; Disease Models, Animal; Galactosamine; Hepatocyte | 2008 |
Control of acute, chronic, and constitutive hyperammonemia by wild-type and genetically engineered Lactobacillus plantarum in rodents.
Topics: Acute Disease; Alanine; Ammonia; Animals; Carbon Tetrachloride; Chronic Disease; Disease Models, Ani | 2008 |
Backflux of ammonia from brain to blood in human subjects with and without hepatic encephalopathy.
Topics: Ammonia; Brain; Brain Chemistry; Cerebrovascular Circulation; Computer Simulation; Hepatic Encephalo | 2009 |
Changes in plasma amino acids during extracorporeal liver support by fractionated plasma separation and adsorption.
Topics: Amino Acids; Ammonia; Chromatography, High Pressure Liquid; Extracorporeal Circulation; Female; Hepa | 2010 |
Alginate-encapsulated HepG2 cells in a fluidized bed bioreactor maintain function in human liver failure plasma.
Topics: Albumins; Alginates; Ammonia; Bilirubin; Bioreactors; Cell Survival; Cell- and Tissue-Based Therapy; | 2009 |
The HepaRG cell line is suitable for bioartificial liver application.
Topics: Ammonia; Apolipoprotein A-I; Biliary Tract; Carbamoyl-Phosphate Synthase (Ammonia); Cell Differentia | 2011 |
[Clinical application of molecular adsorbent recirculating system-artificial liver support system].
Topics: Ammonia; Humans; Liver Failure; Liver, Artificial; Urea | 2002 |
High metabolic function of primary human and porcine hepatocytes in a polyurethane foam/spheroid culture system in plasma from patients with fulminant hepatic failure.
Topics: Ammonia; Animals; Bile Acids and Salts; Cell Culture Techniques; Cells, Cultured; Glycochenodeoxycho | 2002 |
Acute confusional state following liver transplantation for alcoholic liver disease.
Topics: Acute Disease; Aged; Ammonia; Confusion; Creatinine; Female; Hepatitis C; Humans; Length of Stay; Li | 2002 |
Understanding the mechanisms of cerebral complications in fulminant hepatic failure: fluxes better than levels.
Topics: Ammonia; Brain; Hepatic Encephalopathy; Humans; Liver Failure | 2002 |
Recovery of rats with fulminant hepatic failure by using a hybrid artificial liver support system with polyurethane foam/rat hepatocyte spheroids.
Topics: Ammonia; Animals; Equipment Design; Extracorporeal Circulation; Liver; Liver Failure; Liver, Artific | 2002 |
Role of determination of partial pressure of ammonia in cirrhotic patients with and without hepatic encephalopathy.
Topics: Aged; Ammonia; Arteries; Female; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Liver Failure; Mal | 2003 |
Efficacy of a larger version of the hybrid artificial liver support system using a polyurethane foam/spheroid packed-bed module in a warm ischemic liver failure pig model for preclinical experiments.
Topics: Amino Acids; Ammonia; Animals; Bile Acids and Salts; Culture Techniques; Extracorporeal Circulation; | 2003 |
Xenogeneic direct hemoperfusion using whole swine liver for liver failure in dogs.
Topics: Adsorption; Alanine Transaminase; Ammonia; Animals; Aspartate Aminotransferases; Complement C5; Dogs | 2003 |
Ammonia intoxication from portal diversion and hepatic failure.
Topics: Ammonia; Liver Failure; Poisoning; Portal System; Veins; Venae Cavae | 1955 |
DISTRIBUTION OF AMMONIA ACROSS THE BLOODCEREBROSPINAL FLUID BARRIER IN PATIENTS WITH HEPATIC FAILURE.
Topics: Ammonia; Blood; Blood-Brain Barrier; Cerebrospinal Fluid; Hepatic Encephalopathy; Humans; Liver Cirr | 1963 |
Ammonia metabolism in liver failure and some methods of reducing high blood levels.
Topics: Ammonia; Humans; Liver Diseases; Liver Failure; Metabolic Diseases | 1962 |
Use of ultrathin shell microcapsules of hepatocytes in bioartificial liver-assist device.
Topics: Ammonia; Animals; Bilirubin; Capsules; Hepatocytes; Liver Failure; Male; Rats; Rats, Wistar; Time Fa | 2003 |
Identification of optimal classification functions for biological sample and state discrimination from metabolic profiling data.
Topics: Algorithms; Amino Acids; Ammonia; Animals; Biomarkers; Diagnosis, Computer-Assisted; Galactosamine; | 2004 |
Efficacy of immunoadsorbent devices for maintaining hepatic function in ex vivo direct xenogenic hemoperfusion.
Topics: Alanine Transaminase; Ammonia; Animals; Bioreactors; Disease Models, Animal; Dogs; Graft Rejection; | 2004 |
[Description of an experimental model of hepatorenal syndrome in Wistar rats].
Topics: Alanine Transaminase; Ammonia; Animals; Aspartate Aminotransferases; Bilirubin; Disease Models, Anim | 2004 |
Evaluation of plasma ammonia levels in patients with acute liver failure and chronic liver disease and its correlation with the severity of hepatic encephalopathy and clinical features of raised intracranial tension.
Topics: Adult; Ammonia; Brain Edema; Chronic Disease; Female; Hepatic Encephalopathy; Humans; Intracranial H | 2005 |
Neurologic spectrum of chronic liver failure and basal ganglia T1 hyperintensity on magnetic resonance imaging: probable manganese neurotoxicity.
Topics: Adult; Aged; Ammonia; Basal Ganglia Diseases; Brain Chemistry; Cognition Disorders; Female; Gait Ata | 2005 |
Molecular adsorbent recirculating system (MARS) application in liver failure: clinical and hemodepurative results in 22 patients.
Topics: Acute Kidney Injury; Adult; Aged; Ammonia; Bilirubin; Blood Pressure; Chenodeoxycholic Acid; Cholic | 2006 |
Prometheus versus molecular adsorbents recirculating system: comparison of efficiency in two different liver detoxification devices.
Topics: Adult; Aged; Ammonia; Bile Acids and Salts; Bilirubin; Blood Urea Nitrogen; Creatinine; Female; Huma | 2006 |
Molecular adsorbent recirculating system treatment for patients with liver failure: the Hong Kong experience.
Topics: Adult; Aged; Ammonia; Bilirubin; Blood Urea Nitrogen; Female; Hepatectomy; Hepatic Encephalopathy; H | 2006 |
Glutamate-induced activation of nitric oxide synthase is impaired in cerebral cortex in vivo in rats with chronic liver failure.
Topics: Ammonia; Animals; Blotting, Western; Cerebral Cortex; Chronic Disease; Cyclic GMP; Enzyme Activation | 2007 |
MARS dialysis in decompensated alcoholic liver disease: a single-center experience.
Topics: Ammonia; Bilirubin; Female; Humans; Liver Diseases, Alcoholic; Liver Failure; Liver Failure, Acute; | 2007 |
Pretransplant status and patient survival following liver transplantation.
Topics: Adult; Age Factors; Alkaline Phosphatase; Ammonia; Analysis of Variance; Aspartate Aminotransferases | 1995 |
Muscle ammonia and glutamine exchange during chronic liver insufficiency in the rat.
Topics: Amino Acids; Ammonia; Analysis of Variance; Animals; Chronic Disease; Glutamic Acid; Glutamine; Live | 1994 |
Renal ammonia and glutamine metabolism during liver insufficiency-induced hyperammonemia in the rat.
Topics: Ammonia; Animals; Glutamates; Glutamic Acid; Glutamine; Hydrogen-Ion Concentration; Kidney; Kinetics | 1993 |
Cerebral cortex ammonia and glutamine metabolism in two rat models of chronic liver insufficiency-induced hyperammonemia: influence of pair-feeding.
Topics: Amino Acids; Ammonia; Animals; Behavior, Animal; Bile Ducts; Cerebral Cortex; Chronic Disease; Eatin | 1993 |
Administration of a branched-chain amino acid preparation during hepatic failure: a study emphasizing ammonia metabolism.
Topics: Adult; Aged; Alanine; Amino Acids, Branched-Chain; Ammonia; Arteries; Blood Urea Nitrogen; Female; G | 1994 |
Neuronal and glial marker proteins in encephalopathy associated with acute liver failure and acute hyperammonemia in the rabbit.
Topics: Acute Disease; Ammonia; Animals; Hepatic Encephalopathy; Intermediate Filaments; Liver Failure; Nerv | 1993 |
Binding of the ligand [3H]MK-801 to the MK-801 binding site of the N-methyl-D-aspartate receptor during experimental encephalopathy from acute liver failure and from acute hyperammonemia in the rabbit.
Topics: Acute Disease; Ammonia; Animals; Binding Sites; Dizocilpine Maleate; Hepatic Encephalopathy; Liver F | 1993 |
Metabolic adaptation of the kidney to hyperammonemia during chronic liver insufficiency in the rat.
Topics: Adaptation, Physiological; Amino Acids; Ammonia; Animals; Chronic Disease; Glutamine; Kidney; Liver | 1993 |
Relation of taurine transport and brain edema in rats with simple hyperammonemia or liver failure.
Topics: Ammonia; Animals; Basal Ganglia; Body Water; Brain Edema; Cerebral Cortex; Hepatic Encephalopathy; I | 1996 |
Efficacy of a bioreactor filled with porcine hepatocytes immobilized on nonwoven fabric for ex vivo direct hemoperfusion treatment of liver failure in pigs.
Topics: Ammonia; Animals; Bile Acids and Salts; Bioreactors; Blood Coagulation; Blood Glucose; Cells, Immobi | 1998 |
Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration.
Topics: Acute Disease; Adult; Ammonia; Arteries; Encephalocele; Female; Hepatic Encephalopathy; Humans; Live | 1999 |
Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration.
Topics: Acute Disease; Adult; Ammonia; Arteries; Encephalocele; Female; Hepatic Encephalopathy; Humans; Live | 1999 |
Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration.
Topics: Acute Disease; Adult; Ammonia; Arteries; Encephalocele; Female; Hepatic Encephalopathy; Humans; Live | 1999 |
Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration.
Topics: Acute Disease; Adult; Ammonia; Arteries; Encephalocele; Female; Hepatic Encephalopathy; Humans; Live | 1999 |
Evaluation of a hybrid artificial liver using a polyurethane foam packed-Bed culture system in dogs.
Topics: Ammonia; Animals; Blood Glucose; Blood Pressure; Cell Culture Techniques; Creatinine; Dogs; Extracor | 1999 |
Molecular adsorbent recycling system (MARS): clinical results of a new membrane-based blood purification system for bioartificial liver support.
Topics: Adsorption; Adult; Ammonia; Bilirubin; Cholinesterases; Creatinine; Female; Hepatic Encephalopathy; | 1999 |
Efficacy of Nafamostat Mesilate for improving the performance of a bioartificial liver using porcine hepatocytes.
Topics: Alanine Transaminase; Ammonia; Animals; Benzamidines; Cell Survival; Complement Inactivator Proteins | 1999 |
A reversible model of acute hepatic failure by temporary hepatic ischemia in the pig.
Topics: Acute Disease; Ammonia; Animals; Disease Models, Animal; Ischemia; Liver; Liver Failure; Male; Swine | 2000 |
Lovastatin decreases mortality and improves liver functions in fulminant hepatic failure from 90% partial hepatectomy in rats.
Topics: Ammonia; Animals; Blood Coagulation Tests; Blood Glucose; Cell Division; Hepatectomy; Hydroxymethylg | 2000 |
Effect of portacaval anastomosis on glutamine synthetase protein and gene expression in brain, liver and skeletal muscle.
Topics: Ammonia; Animals; Brain; Gene Expression Regulation, Enzymologic; Glutamate-Ammonia Ligase; Hepatic | 1999 |
Loss of noradrenaline transporter sites in frontal cortex of rats with acute (ischemic) liver failure.
Topics: Acute Disease; Ammonia; Animals; Brain Edema; Carrier Proteins; Fluoxetine; Frontal Lobe; Hepatic En | 2001 |
Xenotransplantation of immortalized human hepatocytes for experimental acute liver failure in rats.
Topics: Acute Disease; Ammonia; Animals; Asialoglycoprotein Receptor; Cell Line, Transformed; Cell Transplan | 2000 |
Relative biological effectiveness of carbon ions for causing fatal liver failure after partial hepatectomy in mice.
Topics: Ammonia; Animals; Bromodeoxyuridine; Carbon; DNA Damage; DNA Replication; Dose-Response Relationship | 2000 |
A novel stable reproducible model of hepatic failure in canines.
Topics: Alanine Transaminase; Amino Acids, Branched-Chain; Amino Acids, Cyclic; Ammonia; Animals; Aspartate | 2000 |
The role of hepatocyte transplantation to treat chronic liver failure.
Topics: Ammonia; Animals; Bilirubin; Carbon Tetrachloride; Cell Transplantation; Chronic Disease; Hepatocyte | 2000 |
Effect of bioartificial liver in pigs with total ischemic liver failure.
Topics: Ammonia; Animals; Hepatocytes; Intracranial Pressure; Ischemia; Liver; Liver Failure; Liver, Artific | 2000 |
The efficacy of nafamostat mesilate on the performance of a hybrid-artificial liver using a polyurethane foam/porcine hepatocyte spheroid culture system in human plasma.
Topics: Alanine Transaminase; Ammonia; Animals; Benzamidines; Cell Survival; Female; Guanidines; Humans; Liv | 2001 |
Cerebral blood flow velocity increases during a single treatment with the molecular adsorbents recirculating system in patients with acute on chronic liver failure.
Topics: Acute Disease; Adsorption; Adult; Ammonia; Arteries; Blood Flow Velocity; Cerebrovascular Circulatio | 2001 |
In vivo estimation of bioartificial liver with recombinant HepG2 cells using pigs with ischemic liver failure.
Topics: Ammonia; Animals; Blood Coagulation; Disease Models, Animal; Glucose; Glutamate-Ammonia Ligase; Glut | 2001 |
Cerebral metabolism of ammonia and amino acids in patients with fulminant hepatic failure.
Topics: Adult; Amino Acids; Ammonia; Brain; Female; Humans; Liver Failure; Male; Middle Aged; Respiration, A | 2001 |
Assessment of the AMC-bioartificial liver in the anhepatic pig.
Topics: Alanine Transaminase; Ammonia; Animals; Bilirubin; Female; Hepatectomy; Liver Failure; Liver, Artifi | 2002 |
Pyrrolidine dithiocarbamate protects against thioacetamide-induced fulminant hepatic failure in rats.
Topics: Ammonia; Animals; Antioxidants; Lipid Peroxidation; Liver; Liver Failure; Male; NF-kappa B; Oxidativ | 2002 |
Single vs. dual vessel porcine extracorporeal liver perfusion.
Topics: Ammonia; Animals; Bile; Blood Pressure; Diuresis; Extracorporeal Circulation; Factor V; Female; Hear | 2002 |
Reduced encephalopathy in pigs with ischemia-induced acute hepatic failure treated with a bioartificial liver containing alginate-entrapped hepatocytes.
Topics: Alginates; Ammonia; Animals; Female; Hepatic Encephalopathy; Hepatocytes; Intracranial Pressure; Liv | 2002 |
[The enzymatic activity of ammonia metabolism in the liver during the parenteral nitrogen feeding of animals with experimental liver failure].
Topics: Ammonia; Animals; Carbon Tetrachloride Poisoning; Liver; Liver Failure; Male; Parenteral Nutrition; | 1992 |