ammonium hydroxide has been researched along with Hyperinsulinism in 25 studies
azane : Saturated acyclic nitrogen hydrides having the general formula NnHn+2.
Hyperinsulinism: A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Biochemical evaluation extended to the first-degree relatives is consistent with a familial form of hypoglycemia due to a leucine-sensitive hyperinsulinism." | 7.69 | Biochemical evaluation of a patient with a familial form of leucine-sensitive hypoglycemia and concomitant hyperammonemia. ( Donati, MA; Filippi, L; Novembre, E; Zammarchi, E, 1996) |
| " We hypothesized that this syndrome of hyperinsulinism and hyperammonemia was caused by excessive activity of glutamate dehydrogenase, which oxidizes glutamate to alpha-ketoglutarate and which is a potential regulator of insulin secretion in pancreatic beta cells and of ureagenesis in the liver." | 3.70 | Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene. ( Burlina, AB; Greenberg, CR; Hopwood, NJ; Hsu, BY; Lieu, YK; Perlman, K; Poncz, M; Rich, BH; Stanley, CA; Zammarchi, E, 1998) |
| " Biochemical evaluation extended to the first-degree relatives is consistent with a familial form of hypoglycemia due to a leucine-sensitive hyperinsulinism." | 3.69 | Biochemical evaluation of a patient with a familial form of leucine-sensitive hypoglycemia and concomitant hyperammonemia. ( Donati, MA; Filippi, L; Novembre, E; Zammarchi, E, 1996) |
| "All patients had convulsions or loss of consciousness resulting from hypoglycemia at less than 1 year of age." | 1.31 | Novel missense mutations in the glutamate dehydrogenase gene in the congenital hyperinsulinism-hyperammonemia syndrome. ( Hayashi, Y; Kato, H; Miki, Y; Ohura, T; Taki, T; Yanagisawa, M, 2000) |
| "The hyperinsulinism was successfully treated with diazoxide." | 1.31 | Functional hyperactivity of hepatic glutamate dehydrogenase as a cause of the hyperinsulinism/hyperammonemia syndrome: effect of treatment. ( de Klerk, JB; Duran, M; Huijmans, JG; Rovers, MJ; Scholte, HR, 2000) |
| "A boy suffered from hypoglycemic coma with relative hyperinsulinemia on day 1 after birth, and received subtotal pancreatectomy." | 1.31 | A Japanese case of congenital hyperinsulinism with hyperammonemia due to a mutation in glutamate dehydrogenase (GLUD1) gene. ( Akanuma, Y; Kadowaki, H; Kadowaki, T; Kimura, S; Koda, N; Ogawa, Y; Yasuda, K, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.00) | 18.7374 |
| 1990's | 12 (48.00) | 18.2507 |
| 2000's | 8 (32.00) | 29.6817 |
| 2010's | 3 (12.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brandt, A | 1 |
| Agarwal, N | 1 |
| Giri, D | 1 |
| Yung, Z | 1 |
| Didi, M | 1 |
| Senniappan, S | 1 |
| Walker, V | 1 |
| Brannelly, NT | 1 |
| Hamilton-Shield, JP | 1 |
| Killard, AJ | 1 |
| Balasubramaniam, S | 1 |
| Kapoor, R | 1 |
| Yeow, JH | 1 |
| Lim, PG | 1 |
| Flanagan, S | 1 |
| Ellard, S | 1 |
| Hussain, K | 1 |
| Kofoed, KF | 1 |
| Hove, JD | 1 |
| Freiberg, J | 1 |
| Høst, U | 1 |
| Holm, S | 1 |
| Kelbaek, H | 1 |
| Stanley, CA | 5 |
| Ihara, K | 1 |
| Miyako, K | 1 |
| Ishimura, M | 1 |
| Kuromaru, R | 1 |
| Wang, HY | 1 |
| Yasuda, K | 2 |
| Hara, T | 1 |
| Ang, BC | 1 |
| Halliday, D | 1 |
| Powell-Tuck, J | 1 |
| Zammarchi, E | 2 |
| Filippi, L | 1 |
| Novembre, E | 1 |
| Donati, MA | 1 |
| Weinzimer, SA | 1 |
| Berry, GT | 1 |
| Yudkoff, M | 1 |
| Tuchman, M | 1 |
| Thornton, PS | 2 |
| Wolfsdorf, JI | 1 |
| Lieu, YK | 1 |
| Hsu, BY | 2 |
| Burlina, AB | 1 |
| Greenberg, CR | 1 |
| Hopwood, NJ | 1 |
| Perlman, K | 1 |
| Rich, BH | 1 |
| Poncz, M | 2 |
| Sann, L | 1 |
| al-Shamsan, L | 1 |
| al-Essa, M | 1 |
| al-Mutair, A | 1 |
| al-Ashwal, A | 1 |
| Sakati, N | 1 |
| Ozand, PT | 1 |
| Kamoun, P | 1 |
| Rabier, D | 1 |
| Saudubray, JM | 1 |
| Parini, R | 1 |
| Colombo, F | 1 |
| Lombardi, AM | 1 |
| Menni, F | 1 |
| Beccaria, L | 1 |
| Kitaura, J | 1 |
| Miki, Y | 2 |
| Kato, H | 2 |
| Sakakihara, Y | 1 |
| Yanagisawa, M | 2 |
| Peterson, PE | 1 |
| Smith, TJ | 1 |
| Yorifuji, T | 1 |
| Muroi, J | 1 |
| Uematsu, A | 1 |
| Hiramatsu, H | 1 |
| Momoi, T | 1 |
| Taki, T | 1 |
| Ohura, T | 1 |
| Hayashi, Y | 1 |
| Fang, J | 1 |
| Kutyna, K | 1 |
| Ming, JE | 1 |
| Glaser, B | 1 |
| Huijmans, JG | 1 |
| Duran, M | 1 |
| de Klerk, JB | 1 |
| Rovers, MJ | 1 |
| Scholte, HR | 1 |
| Koda, N | 1 |
| Kadowaki, H | 1 |
| Ogawa, Y | 1 |
| Kimura, S | 1 |
| Kadowaki, T | 1 |
| Akanuma, Y | 1 |
| Kelly, A | 1 |
| Ng, D | 1 |
| Ferry, RJ | 1 |
| Grimberg, A | 1 |
| Koo-McCoy, S | 1 |
| Tews, JK | 1 |
| Carter, SH | 1 |
| Stone, WE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Vitamin E in Hyperinsulinism/Hyperammonemia Syndrome[NCT04984798] | Phase 2 | 0 participants (Actual) | Interventional | 2022-11-30 | Withdrawn (stopped due to No study activity took place. The IND was withdrawn with the FDA by the Sponsor Investigator because of insurmountable hurdles in moving proposed research forward) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for ammonium hydroxide and Hyperinsulinism
| Article | Year |
|---|---|
Ammonia metabolism and hyperammonemic disorders.
Topics: Ammonia; Animals; Arginine; Biological Transport; Brain; Cell Membrane; Humans; Hyperammonemia; Hype | 2014 |
The Measurement of Ammonia in Human Breath and its Potential in Clinical Diagnostics.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Breath Tests; Humans; Hyperinsulinism; Hypoglycemia; | 2016 |
Hyperinsulinism/hyperammonemia syndrome: insights into the regulatory role of glutamate dehydrogenase in ammonia metabolism.
Topics: Adolescent; Ammonia; Animals; Female; Glutamate Dehydrogenase; Humans; Hyperammonemia; Hyperinsulini | 2004 |
2 trials available for ammonium hydroxide and Hyperinsulinism
| Article | Year |
|---|---|
Variability of insulin-stimulated myocardial glucose uptake in healthy elderly subjects.
Topics: Ammonia; Blood Glucose; Dipyridamole; Fluorodeoxyglucose F18; Glucose; Glucose Clamp Technique; Hear | 2002 |
Whole-body protein turnover in response to hyperinsulinemia in humans postabsorptively with [15N]glycine as tracer.
Topics: Adult; Ammonia; Blood Glucose; Carbon Isotopes; Cross-Over Studies; Female; Glucose Clamp Technique; | 1995 |
20 other studies available for ammonium hydroxide and Hyperinsulinism
| Article | Year |
|---|---|
Hyperinsulinism hyperammonaemia (HI/HA) syndrome due to GLUD1 mutation: phenotypic variations ranging from late presentation to spontaneous resolution.
Topics: Ammonia; Blood Glucose; Child; Child, Preschool; Diazoxide; Female; Glutamate Dehydrogenase; Humans; | 2020 |
Biochemical evaluation of an infant with hypoglycemia resulting from a novel de novo mutation of the GLUD1 gene and hyperinsulinism-hyperammonemia syndrome.
Topics: Ammonia; Blood Glucose; Delayed Diagnosis; Female; Glutamate Dehydrogenase; Humans; Hyperinsulinism; | 2011 |
A case of hyperinsulinism/hyperammonaemia syndrome with reduced carbamoyl-phosphate synthetase-1 activity in liver: a pitfall in enzymatic diagnosis for hyperammonaemia.
Topics: Adolescent; Ammonia; Carbamoyl-Phosphate Synthase (Ammonia); Diagnosis, Differential; DNA, Complemen | 2005 |
Biochemical evaluation of a patient with a familial form of leucine-sensitive hypoglycemia and concomitant hyperammonemia.
Topics: Adult; Ammonia; Drug Resistance; Female; Glutamates; Humans; Hyperinsulinism; Hypoglycemia; Infant; | 1996 |
A syndrome of congenital hyperinsulinism and hyperammonemia.
Topics: Ammonia; Child; Child, Preschool; Humans; Hyperinsulinism; Infant; Syndrome | 1997 |
Hyperinsulinemic hypoglycemia of infancy.
Topics: Ammonia; Humans; Hyperinsulinism; Hypoglycemia; Infant | 1998 |
Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene.
Topics: Ammonia; Child; Child, Preschool; DNA Mutational Analysis; Female; Glutamate Dehydrogenase; Humans; | 1998 |
Mechanism of hyperammonemia.
Topics: Ammonia; Humans; Hyperinsulinism; Hypoglycemia; Infant; Infant, Premature | 1998 |
Hyperinsulinism and hyperammonaemia.
Topics: Adolescent; Ammonia; Humans; Hyperinsulinism; Male | 1998 |
Muscular origin of hyperammonaemia.
Topics: Ammonia; Child, Preschool; Glutamate Dehydrogenase; Humans; Hyperinsulinism; Male; Muscle, Skeletal | 1998 |
Hyperinsulinism plus hyperammonemia.
Topics: Ammonia; Child, Preschool; Female; Humans; Hyperinsulinism; Infant | 1998 |
Hyperinsulinaemic hypoglycaemia associated with persistent hyperammonaemia.
Topics: Ammonia; Female; Glutamate Dehydrogenase; Humans; Hyperinsulinism; Hypoglycemia; Infant; Infant, New | 1999 |
The structure of bovine glutamate dehydrogenase provides insights into the mechanism of allostery.
Topics: Adenosine Diphosphate; Allosteric Regulation; Amino Acid Sequence; Amino Acid Substitution; Ammonia; | 1999 |
Hyperinsulinism-hyperammonemia syndrome caused by mutant glutamate dehydrogenase accompanied by novel enzyme kinetics.
Topics: Adenosine Diphosphate; Ammonia; Base Sequence; Dose-Response Relationship, Drug; Genetic Markers; Ge | 1999 |
Novel missense mutations in the glutamate dehydrogenase gene in the congenital hyperinsulinism-hyperammonemia syndrome.
Topics: Adenine; Ammonia; Codon; Cytosine; Female; Glutamate Dehydrogenase; Guanine; Heterozygote; Humans; H | 2000 |
Molecular basis and characterization of the hyperinsulinism/hyperammonemia syndrome: predominance of mutations in exons 11 and 12 of the glutamate dehydrogenase gene. HI/HA Contributing Investigators.
Topics: Adenosine Diphosphate; Allosteric Site; Amino Acid Sequence; Ammonia; Enzyme Activation; Exons; Fema | 2000 |
Functional hyperactivity of hepatic glutamate dehydrogenase as a cause of the hyperinsulinism/hyperammonemia syndrome: effect of treatment.
Topics: Ammonia; Female; Glutamate Dehydrogenase; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Li | 2000 |
A Japanese case of congenital hyperinsulinism with hyperammonemia due to a mutation in glutamate dehydrogenase (GLUD1) gene.
Topics: Allosteric Regulation; Amino Acid Substitution; Ammonia; Apnea; Coma; Genetic Heterogeneity; Glutama | 2001 |
Acute insulin responses to leucine in children with the hyperinsulinism/hyperammonemia syndrome.
Topics: Adolescent; Adult; Amino Acid Substitution; Ammonia; Blood Glucose; Child; Child, Preschool; Diazoxi | 2001 |
Chemical changes in the brain during insulin hypoglycaemia and recovery.
Topics: Acetylcholine; Alanine; Amino Acids; Aminobutyrates; Ammonia; Animals; Aspartic Acid; Brain; Brain C | 1965 |