ammonium hydroxide has been researched along with Hyperemia in 20 studies
azane : Saturated acyclic nitrogen hydrides having the general formula NnHn+2.
Hyperemia: The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).
| Excerpt | Relevance | Reference |
|---|---|---|
| "In 34 patients with HCM, PET was performed using (13)N-labeled ammonia during hyperemia induced by intravenous dipyridamole." | 3.74 | Spatial relationship between coronary microvascular dysfunction and delayed contrast enhancement in patients with hypertrophic cardiomyopathy. ( Betti, I; Camici, PG; Casolo, G; Cecchi, F; Olivotto, I; Pupi, A; Rega, L; Sciagrà, R; Sotgia, B, 2008) |
| "We observed that cerebral hyperemia follows an initial rise in brain water content, rather than in the cerebrospinal fluid concentration of glutamine." | 3.71 | Cerebral hyperemia and nitric oxide synthase in rats with ammonia-induced brain edema. ( Blei, AT; Gottstein, J; Larsen, FS, 2001) |
| " N-13 ammonia was administered intravenously and its distribution in the left ventricular myocardium recorded at rest and during dipyridamole-induced coronary hyperemia." | 3.66 | Noninvasive assessment of coronary stenoses by myocardial imaging during pharmacologic coronary vasodilation. VI. Detection of coronary artery disease in human beings with intravenous N-13 ammonia and positron computed tomography. ( Gomes, A; Gould, KL; Henze, E; Hoffman, EJ; Kuhl, DE; Phelps, ME; Schelbert, HR; Wisenberg, G, 1982) |
| " EM examination of the lungs of the truck driver showed no discernible toxic alterations in either the capillary endothelial cells or the Type I or II alveolar epithelial cells, and alveolar and capillary basement membranes were intact." | 1.27 | Ultrastructure of acute ammonia toxicity in the human lung. ( Burns, TR; Greenberg, SD; Jachimczyk, JA; Mace, ML, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.00) | 18.7374 |
| 1990's | 4 (20.00) | 18.2507 |
| 2000's | 9 (45.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, R | 1 |
| Li, X | 1 |
| Huangfu, S | 1 |
| Yao, Q | 1 |
| Wu, P | 1 |
| Wu, Z | 1 |
| Li, L | 1 |
| Wang, Y | 1 |
| Yang, M | 1 |
| Hacker, M | 1 |
| Zhou, H | 1 |
| Yan, R | 1 |
| Li, S | 1 |
| Hwang, D | 1 |
| Jeon, KH | 1 |
| Lee, JM | 1 |
| Park, J | 1 |
| Kim, CH | 1 |
| Tong, Y | 1 |
| Zhang, J | 1 |
| Bang, JI | 1 |
| Suh, M | 1 |
| Paeng, JC | 1 |
| Na, SH | 1 |
| Cheon, GJ | 1 |
| Cook, CM | 1 |
| Davies, JE | 1 |
| Koo, BK | 1 |
| Giubbini, R | 1 |
| Peli, A | 1 |
| Kruse, MJ | 1 |
| Kovell, L | 1 |
| Kasper, EK | 1 |
| Pomper, MG | 1 |
| Moller, DR | 1 |
| Solnes, L | 1 |
| Chen, ES | 1 |
| Schindler, TH | 1 |
| Packard, RRS | 1 |
| Maddahi, J | 1 |
| Benli, AC | 1 |
| Köksal, G | 1 |
| Ozkul, A | 1 |
| Sotgia, B | 1 |
| Sciagrà, R | 1 |
| Olivotto, I | 1 |
| Casolo, G | 1 |
| Rega, L | 1 |
| Betti, I | 1 |
| Pupi, A | 1 |
| Camici, PG | 1 |
| Cecchi, F | 1 |
| Warskulat, U | 1 |
| Görg, B | 1 |
| Bidmon, HJ | 1 |
| Müller, HW | 1 |
| Schliess, F | 1 |
| Häussinger, D | 1 |
| Kofoed, KF | 1 |
| Hove, JD | 1 |
| Freiberg, J | 1 |
| Høst, U | 1 |
| Holm, S | 1 |
| Kelbaek, H | 1 |
| Jalan, R | 2 |
| Brunken, RC | 1 |
| Perloff, JK | 1 |
| Czernin, J | 4 |
| Campisi, R | 1 |
| Purcell, S | 1 |
| Miner, PD | 1 |
| Child, JS | 1 |
| Schelbert, HR | 5 |
| Bernuau, J | 1 |
| Wisenberg, G | 1 |
| Phelps, ME | 3 |
| Gould, KL | 1 |
| Henze, E | 1 |
| Hoffman, EJ | 1 |
| Gomes, A | 1 |
| Kuhl, DE | 1 |
| Müller, P | 1 |
| Choi, Y | 2 |
| Aguilar, F | 1 |
| Nitzsche, EU | 2 |
| Buxton, DB | 1 |
| Sun, K | 1 |
| Huang, SC | 2 |
| Hoh, CK | 1 |
| Nagamachi, S | 1 |
| Kim, AS | 1 |
| Sun, KT | 1 |
| Böttcher, M | 1 |
| Singh, TP | 1 |
| Di Carli, MF | 1 |
| Sullivan, NM | 1 |
| Leonen, MF | 1 |
| Morrow, WR | 1 |
| Kotzerke, J | 1 |
| Glatting, G | 1 |
| van den Hoff, J | 1 |
| Höher, M | 1 |
| Neumaier, B | 1 |
| Wöhrle, J | 1 |
| Reske, SN | 1 |
| Larsen, FS | 1 |
| Gottstein, J | 1 |
| Blei, AT | 1 |
| Burns, TR | 1 |
| Mace, ML | 1 |
| Greenberg, SD | 1 |
| Jachimczyk, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 2a Study to Evaluate the Safety and Tolerability of OCR-002 (Ornithine Phenylacetate) in the Treatment of Patients With Acute Liver Failure/Severe Acute Liver Injury[NCT01548690] | Phase 2 | 47 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
To evaluate the effect of OCR-002 on ammonia levels in patients with acute liver failure/severe acute liver injury (NCT01548690)
Timeframe: Baseline and 72 Hours
| Intervention | Percent Change (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 41.2 |
| Maximum Dose Level 6.65 g/24h | 16.6 |
| Maximum Dose Level 10 g/24h | 41.8 |
| Maximum Dose Level 20g/24h | 38.4 |
To evaluate the steady state pharmacokinetic and pharmacodynamic profile of OCR-002 in patients with impaired and intact renal function using urinary phenylacetylglutamine (PAGN) as a surrogate marker (NCT01548690)
Timeframe: 24 Hours after last infusion
| Intervention | micrograms per millileter (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 65.6 |
| Maximum Dose Level 6.65 g/24h | 32.2 |
| Maximum Dose Level 10 g/24h | 33.4 |
| Maximum Dose Level 20g/24h | 104.9 |
The orientation log focuses on orientation to place, time, and circumstance. There are 10 items on the orientation log, which are scored 0-3. A spontaneous correct response is awarded 3 points. A spontaneous response that is lacking or incorrect, but a correct response is provided following a logical cue is awarded 2 points. A score of 1 is given if spontaneous and cued responses are lacking or incorrect, but a correct response is provided in a recognition format. A score of 0 is given if the spontaneous, cued, or recognition format does not generate a correct answer. Scores from the 10 items are summed and the final score ranges from 0 to 30. (NCT01548690)
Timeframe: 30 Days
| Intervention | units on a scale (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 23.8 |
| Maximum Dose Level 6.65 g/24h | 24.0 |
| Maximum Dose Level 10 g/24h | 24.0 |
| Maximum Dose Level 20g/24h | 24.0 |
The West Haven Criteria (WHC) for Hepatic Encephalopathy measures the severity of encephalopathy and patient's level of consciousness. The scale ranges from 0 to 4; a minimum score of 0 represents a better outcome, and a maximum total score of 4 represents a worse outcome. A score of 0 corresponds to normal consciousness and behavior and normal neurological examination. A score of 1 corresponds to mild lack of awareness, shortened attention span, and impaired addition or subtraction; mild asterixis or tremor. A score of 2 corresponds to lethargy, disorientated or inappropriate behavior, obvious asterixis; slurred speech. A score of 3 corresponds to somnolent but arousable, gross disorientation or bizarre behavior, muscle rigidity and clonus; hyperreflexia. A score of 4 corresponds to coma and decerebrate posturing. (NCT01548690)
Timeframe: 120 hours from start of infusion
| Intervention | units on a scale (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 2.4 |
| Maximum Dose Level 6.65 g/24h | 3.2 |
| Maximum Dose Level 10 g/24h | 1.6 |
| Maximum Dose Level 20g/24h | 1.8 |
To evaluate the safety and tolerability of OCR-002 in patients with acute liver failure/severe acute liver injury (NCT01548690)
Timeframe: 30 Days
| Intervention | Participants (Count of Participants) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 0 |
| Maximum Dose Level 6.65 g/24h | 0 |
| Maximum Dose Level 10 g/24h | 0 |
| Maximum Dose Level 20g/24h | 0 |
2 reviews available for ammonium hydroxide and Hyperemia
| Article | Year |
|---|---|
Pathophysiological basis of therapy of raised intracranial pressure in acute liver failure.
Topics: Ammonia; Animals; Brain Edema; Cerebrovascular Circulation; Encephalitis; Hepatic Encephalopathy; Hu | 2005 |
Induction of cerebral hyperemia by ammonia plus endotoxin: does hyperammonemia unlock the blood-brain barrier?
Topics: Ammonia; Animals; Blood-Brain Barrier; Brain; Endotoxins; Humans; Hyperemia; Lipopolysaccharides | 2007 |
3 trials available for ammonium hydroxide and Hyperemia
| Article | Year |
|---|---|
Variability of insulin-stimulated myocardial glucose uptake in healthy elderly subjects.
Topics: Ammonia; Blood Glucose; Dipyridamole; Fluorodeoxyglucose F18; Glucose; Glucose Clamp Technique; Hear | 2002 |
Noninvasive quantification of myocardial blood flow in humans. A direct comparison of the [13N]ammonia and the [15O]water techniques.
Topics: Adenosine; Adult; Ammonia; Animals; Coronary Circulation; Coronary Vessels; Dogs; Female; Half-Life; | 1996 |
Validation of myocardial blood flow estimation with nitrogen-13 ammonia PET by the argon inert gas technique in humans.
Topics: Adenosine; Aged; Algorithms; Ammonia; Argon; Coronary Circulation; Female; Heart; Hemodynamics; Huma | 2001 |
15 other studies available for ammonium hydroxide and Hyperemia
| Article | Year |
|---|---|
Combining body mass index with waist circumference to assess coronary microvascular function in patients with non-obstructive coronary artery disease.
Topics: Ammonia; Body Mass Index; Coronary Artery Disease; Coronary Circulation; Humans; Hyperemia; Myocardi | 2022 |
Diagnostic Performance of Resting and Hyperemic Invasive Physiological Indices to Define Myocardial Ischemia: Validation With
Topics: Aged; Ammonia; Area Under Curve; Arterial Pressure; Cardiac Catheterization; Coronary Angiography; C | 2017 |
Left ventricular function during hyperemia: A dive into the unknown.
Topics: Ammonia; Humans; Hyperemia; Nitrogen Radioisotopes; Ventricular Function; Ventricular Function, Left | 2018 |
Myocardial Blood Flow and Inflammatory Cardiac Sarcoidosis.
Topics: Ammonia; Blood Flow Velocity; Cardiomyopathies; Coronary Circulation; Female; Fluorodeoxyglucose F18 | 2017 |
Regadenoson-induced hyperemia for absolute myocardial blood flow quantitation by
Topics: Allografts; Ammonia; Coronary Circulation; Humans; Hyperemia; Nitrogen Radioisotopes; Purines; Pyraz | 2017 |
Sublethal ammonia exposure of Nile tilapia (Oreochromis niloticus L.): effects on gill, liver and kidney histology.
Topics: Ammonia; Animals; Chemical and Drug Induced Liver Injury; Cichlids; Gills; Glomerulonephritis; Hydro | 2008 |
Spatial relationship between coronary microvascular dysfunction and delayed contrast enhancement in patients with hypertrophic cardiomyopathy.
Topics: Adolescent; Adult; Aged; Ammonia; Cardiomyopathy, Hypertrophic; Contrast Media; Coronary Circulation | 2008 |
Ammonia-induced heme oxygenase-1 expression in cultured rat astrocytes and rat brain in vivo.
Topics: Ammonia; Animals; Animals, Newborn; Antioxidants; Astrocytes; Cells, Cultured; Cerebral Cortex; Gene | 2002 |
Myocardial perfusion reserve in adults with cyanotic congenital heart disease.
Topics: Adult; Ammonia; Blood Gas Analysis; Coronary Circulation; Female; Heart Defects, Congenital; Hemodyn | 2005 |
Noninvasive assessment of coronary stenoses by myocardial imaging during pharmacologic coronary vasodilation. VI. Detection of coronary artery disease in human beings with intravenous N-13 ammonia and positron computed tomography.
Topics: Adolescent; Adult; Aged; Ammonia; Coronary Disease; Coronary Vessels; Dipyridamole; Female; Humans; | 1982 |
Effect of exercise supplementation during adenosine infusion on hyperemic blood flow and flow reserve.
Topics: Adenosine; Adult; Ammonia; Aorta; Blood Pressure; Coronary Circulation; Coronary Vessels; Electrocar | 1994 |
Reproducibility of measurements of regional resting and hyperemic myocardial blood flow assessed with PET.
Topics: Adenosine; Adult; Ammonia; Coronary Circulation; Dipyridamole; Female; Hemodynamics; Humans; Hyperem | 1996 |
Myocardial flow reserve in long-term survivors of repair of anomalous left coronary artery from pulmonary artery.
Topics: Adenosine; Adolescent; Adult; Ammonia; Blood Pressure; Carbon Dioxide; Cardiac Output; Case-Control | 1998 |
Cerebral hyperemia and nitric oxide synthase in rats with ammonia-induced brain edema.
Topics: Ammonia; Anesthesia, General; Animals; Arteries; Body Water; Brain; Brain Edema; Cerebrovascular Cir | 2001 |
Ultrastructure of acute ammonia toxicity in the human lung.
Topics: Adult; Ammonia; Basement Membrane; Edema; Endothelium; Epithelium; Female; Humans; Hyperemia; Lung; | 1985 |