ammonium hydroxide has been researched along with Hepatic Encephalopathy in 1380 studies
azane : Saturated acyclic nitrogen hydrides having the general formula NnHn+2.
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to investigate the clinical effect of probiotics combined with lactulose for minimal hepatic encephalopathy (MHE) treatment." | 9.69 | Clinical study of probiotics combined with lactulose for minimal hepatic encephalopathy treatment. ( Li, F; Shi, J, 2023) |
| "The objective was to evaluate the efficacy and safety of sodium benzoate in the management of hyperammonemia and hepatic encephalopathy (HE) in decompensated chronic liver disease." | 9.34 | Efficacy and Safety of Sodium Benzoate in The Management of Hyperammonemia in Decompensated Chronic Liver Disease of the Childhood-A Double-blind Randomized Controlled Trial. ( Alam, S; Khanna, R; Lal, BB; Snehavardhan, P; Sood, V, 2020) |
| "Intestinal mannitol is as effective and safe as conventional treatment for reducing hyperammonemia, oxidative stress, and hepatic encephalopathy of CLD patients in the emergency room." | 9.27 | Impact of intestinal mannitol on hyperammonemia, oxidative stress and severity of hepatic encephalopathy in the ED. ( Cruz-Domínguez, MP; Jara, LJ; Montes-Cortés, DH; Novelo-Del Valle, JL; Olivares-Corichi, IM; Rosas-Barrientos, JV, 2018) |
| "Lactulose is effective in secondary prophylaxis of hepatic encephalopathy (HE)." | 9.16 | Secondary prophylaxis of hepatic encephalopathy in cirrhosis: an open-label, randomized controlled trial of lactulose, probiotics, and no therapy. ( Agrawal, A; Sarin, SK; Sharma, BC; Sharma, P, 2012) |
| "To evaluate the influence of L-carnitine on mental conditions and ammonia effects on patients with hepatic encephalopathy (HE)." | 9.11 | Effects of L-carnitine in patients with hepatic encephalopathy. ( Elvira, R; Leotta, C; Liborio, R; Malaguarnera, M; Pistone, G; Scarpello, L, 2005) |
| "The efficacy and safety of rifaximin in comparison with lactitol in the treatment of acute hepatic encephalopathy was assessed in a prospective randomized, double-blind, double-dummy, controlled trial." | 9.10 | Comparison of rifaximin and lactitol in the treatment of acute hepatic encephalopathy: results of a randomized, double-blind, double-dummy, controlled clinical trial. ( Castells, L; Coll, I; Fernández-Rodríguez, C; Mas, A; Pardo, A; Planas, R; Rodés, J; Rodrigo, L; Rodríguez-Martínez, D; Sunyer, L; Vargas, V, 2003) |
| "To observe the long-term clinical efficacy of lactulose in patients with subclinical hepatic encephalopathy (SHE) and the natural history of this disease." | 9.10 | [Long-term efficacy of lactulose in patients with subclinical hepatic encephalopathy]. ( Dai, SJ; Li, YY; Nie, YQ; Ping, L; Sha, WH; Zeng, Z, 2003) |
| "To observe the natural history of subclinical hepatic encephalopathy (SHE) and to compare the efficacy of long-term and short-term treatment of lactulose." | 9.10 | [Effects of lactulose treatment on the course of subclinical hepatic encephalopathy]. ( Li, YY; Zeng, Z, 2003) |
| ", we determined the effect on chronic hepatic encephalopathy of long-term administration of Enterococcus faecium (SF68) versus lactulose." | 9.08 | Long-term effects of Enterococcus faecium SF68 versus lactulose in the treatment of patients with cirrhosis and grade 1-2 hepatic encephalopathy. ( Abbiati, R; Coltorti, M; Del Vecchio Blanco, C; Loguercio, C; Rinaldi, M; Romano, A, 1995) |
| "We aimed to investigate the effect of L-carnitine on biochemical factors including ammonia, bilirubin, albumin, alanine aminotransferase, aspartate aminotransferase (AST), blood urea nitrogen (BUN), and creatinine (Cr) in patients with hepatic encephalopathy (HE)." | 9.01 | Effect of L-carnitine on liver enzymes and biochemical factors in hepatic encephalopathy: A systematic review and meta-analysis. ( Abbasnezhad, A; Alipour, M; Asbaghi, O; Choghakhori, R; Kashkooli, S; Mohammadi, R, 2019) |
| "Acute liver failure (ALF) is characterized neuropathologically by cytotoxic brain edema and biochemically by increased brain ammonia and its detoxification product, glutamine." | 8.88 | Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure: role of glutamine redefined. ( Butterworth, RF; Desjardins, P; Du, T; Jiang, W; Peng, L, 2012) |
| "To evaluate the clinical efficacy of lactulose in patients with minimal hepatic encephalopathy (MHE)." | 8.87 | Clinical efficacy and safety of lactulose for minimal hepatic encephalopathy: a meta-analysis. ( Cao, WK; Li, L; Lu, CZ; Luo, M, 2011) |
| "Lactulose is the most frequently utilized agent in the treatment of hepatic encephalopathy because of its efficacy and the fact that it has few serious side effects." | 8.79 | Lactulose and combination therapy of hepatic encephalopathy: the role of the intestinal microflora. ( Weber, FL, 1996) |
| "This study was to investigate the effects of ammonia and manganese in the metabolism of minimal hepatic encephalopathy (MHE)." | 8.31 | The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study. ( Li, Y; Liu, XF; Lu, JJ; Qiang, JW; Yang, XY, 2023) |
| "The objective of this study was to elucidate the effects of syringic acid on thioacetamide-induced hepatic encephalopathy which is a complex serious syndrome with neuropsychiatric abnormalities related to acute liver dysfunctions like cirrhosis." | 8.12 | Syringic acid protects against thioacetamide-induced hepatic encephalopathy: Behavioral, biochemical, and molecular evidence. ( Bayram, C; Ertugrul, MS; Ferah Okkay, I; Gundogdu, OL; Hacimuftuoglu, A; Mendil, AS; Okkay, U, 2022) |
| "This study aimed to investigate the possible usefulness of morin flavonoid in comparison to silymarin as a hepatic/neuronal-supportive agent with similar effects and higher bioavailability in a rat model of hepatic encephalopathy (HE)." | 8.12 | Molecular mechanisms involved in the effects of morin in experimental hepatic encephalopathy. ( Attia, AS; El-Ghazaly, MA; Rashed, ER; Shafey, GM; Zaki, HF, 2022) |
| "To investigate the metabolic changes in type C hepatic encephalopathy (CHE) rats after reducing manganese (Mn) intake." | 8.12 | Metabolic changes of the reduction of manganese intake in the hepatic encephalopathy rat: NMR- and MS-based metabolomics study. ( Li, Y; Lu, J; Qiang, J; Yang, X; Zhang, C, 2022) |
| "This study investigated the influence of chitosan oligosaccharides (COSs) on a thioacetamide-induced hepatic encephalopathy (HE) Wistar rat model." | 8.12 | Ameliorative Effect of Chitosan Oligosaccharides on Hepatic Encephalopathy by Reshaping Gut Microbiota and Gut-Liver Axis. ( Chen, L; Ge, Y; He, H; Li, X; Li, Z; Liu, Y; Luo, X; Ma, W; Qi, W; Wang, N; Wang, X; Zhang, T, 2022) |
| "Acetaminophen-induced hepatotoxicity can result in hyperammonemia, but it is not clear if elevated ammonia concentrations predict encephalopathy." | 8.12 | Hyperammonemia in acetaminophen toxicity. ( Marino, RT; Sidlak, AM, 2022) |
| "The aim of this study was to determine whether oral L-carnitine administration reduces the blood ammonia concentration and number of hospital admissions for hepatic encephalopathy in patients with advanced cirrhosis." | 8.02 | L-carnitine reduces hospital admissions in patients with hepatic encephalopathy. ( Fujita, K; Himoto, T; Kobara, H; Masaki, T; Mimura, S; Morishita, A; Nakahara, M; Nomura, T; Oura, K; Sakamoto, T; Tadokoro, T; Takuma, K; Tani, J; Yoneyama, H, 2021) |
| " The current investigation was designed to evaluate the role of taurine treatment on the brain and liver mitochondrial function in a rat model of hepatic encephalopathy and hyperammonemia." | 7.85 | Taurine treatment preserves brain and liver mitochondrial function in a rat model of fulminant hepatic failure and hyperammonemia. ( Abasvali, M; Abdoli, N; Asadi, B; Azarpira, N; Heidari, R; Jafari, F; Jamshidzadeh, A; Khodaei, F; Latifpour, Z; Mardani, E; Najibi, A; Ommati, MM; Yeganeh, Y; Zarei, A; Zarei, M, 2017) |
| "Brain manganese deposition is led by liver dysfunction and/or portal-systemic shunting in minimal hepatic encephalopathy (MHE)." | 7.85 | Reduction of manganese intake improves neuropsychological manifestations in rats with minimal hepatic encephalopathy. ( Ji, CX; Ju, S; Li, Y; Mei, LH; Qiang, JW, 2017) |
| " L-Carnitine is a vitamin-like substance and several reports have described the usefulness of L-carnitine supplementation in cases of cirrhosis, with confirmed effectiveness against refractory hepatic encephalopathy." | 7.81 | Usefulness of Levocarnitine and/or Branched-Chain Amino Acids during Invasive Treatment for Hepatocellular Carcinoma. ( Hasegawa, H; Ishihara, T; Iwasa, M; Kobayashi, Y; Mifuji-Moroka, R; Sekoguchi-Fujikawa, N; Sugimoto, R; Takei, Y; Tanaka, H; Yoshikawa, K, 2015) |
| "Ammonia production is implicated in the pathogenesis of hepatic encephalopathy (HE), being intestinal glutaminase activity the main source for ammonia." | 7.80 | THDP17 decreases ammonia production through glutaminase inhibition. A new drug for hepatic encephalopathy therapy. ( Bautista, J; Carbonero-Aguilar, P; del Campo, JA; Díaz-Herrero, MM; Iglesias-Guerra, F; Miñano, FJ; Periñán, I; Romero-Gómez, M; Vega-Pérez, JM, 2014) |
| "In cirrhotic patients, an oral glutamine load improves the psychometric diagnostic performance for minimal hepatic encephalopathy." | 7.79 | Oral glutamine challenge improves the performance of psychometric tests for the diagnosis of minimal hepatic encephalopathy in patients with liver cirrhosis. ( Cojocariu, C; Irimia, R; Sfarti, C; Stanciu, C; Trifan, A, 2013) |
| "To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective cohort of diabetic cirrhotic patients." | 7.78 | Metformin inhibits glutaminase activity and protects against hepatic encephalopathy. ( Ampuero, J; Bautista, JD; Camacho, I; del Campo, JA; Díaz-Herrero, Mdel M; Figueruela, B; Maraver, M; Nuñez, D; Ranchal, I; Rojas, Á; Romero-Gómez, M, 2012) |
| "Intestinal bacteria metabolize tryptophan into indole, which is then further metabolized into oxindole, a sedative compound putatively involved in the pathophysiology of hepatic encephalopathy (HE)." | 7.76 | Peripheral and splanchnic indole and oxindole levels in cirrhotic patients: a study on the pathophysiology of hepatic encephalopathy. ( Angeloni, S; Carlà, V; Mannaioni, G; Merli, M; Moroni, F; Ridola, L; Riggio, O; Salvatori, FM, 2010) |
| "To compare the efficacy of probiotic preparation Golden Bifid and lactulose on rat experimental model of minimal hepatic encephalopathy (MHE) induced by thioactamide (TAA)." | 7.73 | Comparison of probiotics and lactulose in the treatment of minimal hepatic encephalopathy in rats. ( Jia, L; Zhang, MH, 2005) |
| "We treated a 49-yr-old man with neostigmine, who had liver cirrhosis, acute hepatic encephalopathy, and acute intestinal pseudoobstruction." | 7.73 | Neostigmine for the treatment of acute hepatic encephalopathy with acute intestinal pseudo-obstruction in a cirrhotic patient. ( Choi, SK; Joo, YE; Kim, HS; Kim, SJ; Park, CH; Rew, JS, 2005) |
| "Chronic methimazole treatment alleviates hepatic encephalopathy and liver damage in rats with BDL-induced hepatic cirrhosis." | 7.73 | Methimazole alleviates hepatic encephalopathy in bile-duct ligated cirrhotic rats. ( Chan, CY; Chang, CC; Chang, FY; Chen, YC; Huang, HC; Lee, FY; Lee, SD; Lin, HC; Wang, SS, 2006) |
| "We assessed the usefulness of oral glutamine challenge (OGC) and minimal hepatic encephalopathy in evaluating risk of overt hepatic encephalopathy in cirrhotic patients." | 7.71 | Altered response to oral glutamine challenge as prognostic factor for overt episodes in patients with minimal hepatic encephalopathy. ( Benitez, S; Camacho, I; Castro, M; Grande, L; Irles, JA; Romero-Gómez, M, 2002) |
| "Recent data from animal studies suggest that induced hypothyroidism prevents the hyperdynamic circulation in portal vein ligated rats, liver cirrhosis in rats chronically treated with thioacetamide (TAA), and immune-mediated acute liver injury induced in mice by concanavalin A." | 7.70 | Hypothyroidism minimizes liver damage and improves survival in rats with thioacetamide induced fulminant hepatic failure. ( Aeed, H; Avni, Y; Bruck, R; Halpern, Z; Matas, Z; Oren, R; Papa, M; Shirin, H; Zaidel, L, 1998) |
| "Therapeutic modulation of the increased GABAergic tone in chronic hepatic encephalopathy (HE) by the benzodiazepine receptor (BR) antagonist flumazenil (F) has led to conflicting results in humans and animal models for HE." | 7.70 | Improvement of chronic hepatic encephalopathy in dogs by the benzodiazepine-receptor partial inverse agonist sarmazenil, but not by the antagonist flumazenil. ( Legemate, DA; Meyer, HP; Rothuizen, J; van den Brom, W, 1998) |
| "Lactitol, a non-absorbable synthetic disaccharide, was administered at a dose of 36g/day for 3-4 weeks to 8 patients with liver cirrhosis and hepatic encephalopathy in order to investigate its effects on fecal bacterial flora and clinical symptoms of hepatic encephalopathy." | 7.69 | [Effects of lactitol on fecal bacterial flora in patients with liver cirrhosis and hepatic encephalopathy]. ( Hayashi, M; Ito, Y; Okawa, S; Tamai, S; Tarao, K, 1995) |
| "High affinity [3H]gamma-aminobutyric acid (GABA) and [3H]L-glutamate uptake were determined in synaptosomes prepared from the cerebral cortex of dogs with congenital hepatic encephalopathy and control dogs." | 7.69 | L-glutamate and gamma-aminobutyric acid uptake in synaptosomes from the cerebral cortex of dogs with congenital chronic hepatic encephalopathy. ( Johnston, GA; Maddison, JE; Watson, WE, 1995) |
| "We successfully anesthetized a 53-year-old female with hypercitrullinemia and severe liver cirrhosis." | 7.69 | [Anesthetic management for a patient with citrullinemia and liver cirrhosis]. ( Igarashi, M; Iwasaki, H; Kawana, S; Namiki, A, 1995) |
| "Brain myo-inositol, an organic osmolyte, is decreased in cirrhotic patients with hepatic encephalopathy but appears unchanged in fulminant hepatic failure." | 7.69 | Glutamine, myo-inositol, and organic brain osmolytes after portocaval anastomosis in the rat: implications for ammonia-induced brain edema. ( Blei, AT; Cordoba, J; Gottstein, J, 1996) |
| "Levels of cholecystokinin (CCK) immunoreactivity and distribution of CCK immunoreactive cells were studied in the cerebral cortex of LEC (Long Evans Cinnamon) rats with hepatic encephalopathy." | 7.68 | Reduced cholecystokinin in the brain of LEC rats with hepatic encephalopathy. ( Kobayashi, H; Madarame, T; Matsuoka, Y; Miura, Y; Sato, S; Suzuki, K; Takeichi, N; Tateishi, K; Yoshida, T, 1991) |
| "The possible involvement of taurine in the pathogenesis of hepatic encephalopathy was studied in rats injected with thioacetamide." | 7.68 | Taurine release from brain slices in thioacetamide-induced hepatic encephalopathy in rats. ( Oja, SS; Saransaari, P; Wysmyk, U, 1991) |
| "Significant elevation of glutamic acid and glutamine concentrations in CSF was observed in hepatic encephalopathic patients with fulminant hepatitis and liver cirrhosis." | 7.67 | Glutamic acid and glutamine levels in serum and cerebrospinal fluid in hepatic encephalopathy. ( Fujiwara, M; Higashi, T; Nagashima, H; Nakatsukasa, H; Sakata, T; Shiota, T; Takei, N; Watanabe, A, 1984) |
| "Cerebral blood flow (CBF), measured by the noninvasive xenon-133 inhalation method, EEG, and plasma levels of ammonia (NH3) and free tryptophan were determined in 18 hospitalized cirrhotic patients affected with subclinical hepatic encephalopathy, as diagnosed by the Kurtz test." | 7.67 | Reduction of cerebral blood flow in subclinical hepatic encephalopathy and its correlation with plasma-free tryptophan. ( Celle, G; Gris, A; Marenco, S; Nobili, F; Novellone, G; Rodriguez, G; Rosadini, G; Testa, R, 1987) |
| "Lactulose is currently the drug of choice for the treatment of hepatic encephalopathy." | 7.67 | Lactitol in the treatment of chronic hepatic encephalopathy: an open comparison with lactulose. ( Lanthier, PL; Morgan, MY, 1985) |
| "Hepatic encephalopathy in patients with severe liver disease was associated with marked elevation of either serum methionine or blood ammonia levels or with simultaneous moderate increases in both parameters." | 7.66 | Impaired metabolism of methionine in severe liver diseases. II. Clinical and experimental studies on role of impaired methionine metabolism in pathogenesis of hepatic encephalopathy. ( Higashi, T, 1982) |
| "It has been recently proposed that hepatic encephalopathy could be due to the accumulation of octopamine acting as a false neurotransmitter, and the increase of ammonia might reflect this accumulation." | 7.65 | Octopamine and ammonia plasma levels in hepatic encephalopathy. ( Angelico, M; Attili, AF; Cangiano, C; Capocaccia, L; Cascino, A; Rossi Fanelli, F, 1977) |
| "The aim of this study was to specify the mechanism of hepatic encephalopathy which may occur in some cirrhotics treated by Spironolactone." | 7.65 | [Hyperammonemia and hepatic encephalopathy in cirrhotics receiving spironolactone (author's transl)]. ( Imler, M; Schlienger, JL, 1977) |
| " Plasma levels of ornithine and phenylacetic acid (PAA) and plasma/urinary levels of phenylacetylglutamine (PAGN) (primary metabolite of PAA) were regularly assessed; plasma ammonia level was the primary pharmacodynamic variable." | 7.11 | Pharmacokinetics/pharmacodynamics of L-ornithine phenylacetate in overt hepatic encephalopathy and the effect of plasma ammonia concentration reduction on clinical outcomes. ( Bajaj, JS; Bukofzer, S; Devarakonda, KR; Jamil, K; Potthoff, A; Pyrsopoulos, N; Rahimi, RS; Ram Bhamidimarri, K; Safadi, R; Thabut, D; Wang, L, 2022) |
| "Minimal hepatic encephalopathy (MHE) impairs daily functioning and health-related quality of life (HRQoL)." | 6.76 | A randomized controlled trial comparing lactulose, probiotics, and L-ornithine L-aspartate in treatment of minimal hepatic encephalopathy. ( Mittal, VV; Sarin, SK; Sharma, BC; Sharma, P, 2011) |
| "The pathogenesis of hepatic encephalopathy is controversial although ammonia has been found to induce cerebral dysfunction." | 6.73 | Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. ( Barone, G; Gargante, MP; Greco, F; Malaguarnera, M; Toscano, MA, 2007) |
| "Minimal hepatic encephalopathy (MHE) is associated with poor quality of life and increased work disability." | 6.73 | An open-label randomized controlled trial of lactulose and probiotics in the treatment of minimal hepatic encephalopathy. ( Puri, V; Sarin, SK; Sharma, BC; Sharma, P, 2008) |
| "When propranolol was administered to patients with alcoholic cirrhosis and marginal liver function, as reflected by ammonia levels above 60 microM, it caused a significant increase in ammonia levels in arterialized-venous and arterial, but not in venous, blood (p less than 0." | 6.66 | Venous, arterial, and arterialized-venous blood ammonia levels and their relationship to hepatic encephalopathy after propranolol. ( Lieber, CS; Snady, H, 1988) |
| "Sodium benzoate is an alternate method of nonbacterial, non-hepatic metabolic binding pathway for ammonia disposal." | 6.42 | Role of gut bacteria in the therapy of hepatic encephalopathy with lactulose and antibiotics. ( Dasarathy, S, 2003) |
| "This study aimed to investigate the clinical effect of probiotics combined with lactulose for minimal hepatic encephalopathy (MHE) treatment." | 5.69 | Clinical study of probiotics combined with lactulose for minimal hepatic encephalopathy treatment. ( Li, F; Shi, J, 2023) |
| "We aim to develop a nomogram to predict overt hepatic encephalopathy (OHE) after transjugular intrahepatic portosystemic shunt (TIPS) in patients with portal hypertension, according to demographic/clinical indicators such as age, creatinine, blood ammonia, indocyanine green retention rate at 15 min (ICG-R15) and percentage of Portal pressure gradient (PPG) decline." | 5.69 | A novel nomogram predicting overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in portal hypertension patients. ( Bao, L; Chen, SB; Cui, T; Dong, CB; Fan, ZH; Liao, Y; Liu, FQ; Meng, MM; Wang, JT; Wang, L; Wang, XQ; Wu, YF; Yue, ZD; Zhang, L; Zhang, Y, 2023) |
| "The current therapies for hepatic encephalopathy (HE) are not completely effective in all patients, probably due to the physiopathological heterogeneity and the different conditions underlying the bout of HE." | 5.56 | Oral glutamine challenge is a marker of altered ammonia metabolism and predicts the risk of hepatic encephalopathy. ( Ampuero, J; Camacho, I; Gil, A; Millán, R; Rico, MC; Romero-Gómez, M; Viloria, MDM, 2020) |
| "metformin was associated with a significant inhibition of glutaminase activity levels in the small intestine of porto-caval shunted rats (0." | 5.48 | Metformin modifies glutamine metabolism in an in vitro and in vivo model of hepatic encephalopathy. ( Ampuero, J; Gallego-Durán, R; García-Valdecasas, M; Gil-GÓmez, A; Gómez-Sotelo, AI; Muñoz-Hernández, R; Ranchal, I; Rojas, Á; Romero Gómez, M, 2018) |
| "Hepatic encephalopathy is a major complication in patients with advanced cirrhosis and is associated with poor prognosis." | 5.48 | L-Carnitine for the Treatment of Overt Hepatic Encephalopathy in Patients with Advanced Liver Cirrhosis. ( Futsukaichi, Y; Kobayashi, S; Minemura, M; Sugiyama, T; Tajiri, K; Takahara, T; Yasumura, S, 2018) |
| "Treatment with rutin resulted in improvement in liver function by the decline in serum AST and ALT activities and reduction in serum ammonia level." | 5.46 | Ameliorative effects of rutin on hepatic encephalopathy-induced by thioacetamide or gamma irradiation. ( El-Marakby, SM; Mansour, SZ; Moawed, FSM, 2017) |
| "Minimal hepatic encephalopathy is associated with poor prognosis and mortality in patients with cirrhosis." | 5.46 | Lactulose reduces bacterial DNA translocation, which worsens neurocognitive shape in cirrhotic patients with minimal hepatic encephalopathy. ( Ampuero, J; Bellot, P; Figueruela, B; Francés, R; Gallego-Durán, R; González-Navajas, JM; Martínez-Moreno, B; Moratalla, A; Roger, M; Romero-Gómez, M; Such, J; Zapater, P, 2017) |
| "MHE was diagnosed with psychometric hepatic encephalopathy score (PHES) ≤ -5." | 5.46 | Sleep disturbances in patients of liver cirrhosis with minimal hepatic encephalopathy before and after lactulose therapy. ( Puri, V; Sachdeva, S; Sharma, BC; Singh, J; Srivastava, S, 2017) |
| "Spironolactone is an aldosterone receptor antagonist used to control fluid overload in cirrhotic patients although recent studies suggest that it also inhibits angiogenesis." | 5.42 | The Impact of Spironolactone on the Severity of Portal-Systemic Collaterals and Hepatic Encephalopathy in Cirrhotic Rats. ( Chang, CC; Ho, HL; Hsin, IF; Hsu, SJ; Huang, HC; Huo, TI; Lee, FY; Lee, SD; Lin, HC; Wang, SS, 2015) |
| "Hepatic encephalopathy is a neuropsychiatric disorder of complex pathogenesis caused by acute or chronic liver failure." | 5.37 | Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice. ( Avraham, Y; Berry, E; Grigoriadis, N; Ilan, Y; Magen, I; Mechoulam, R; Poutahidis, T; Vorobiev, L, 2011) |
| "Hepatic encephalopathy is a severe neuropathological condition arising secondary to liver failure." | 5.35 | Metabolic fate of isoleucine in a rat model of hepatic encephalopathy and in cultured neural cells exposed to ammonia. ( Bak, LK; Iversen, P; Keiding, S; Ott, P; Schousboe, A; Sørensen, M; Vilstrup, H; Waagepetersen, HS, 2009) |
| "Minimal hepatic encephalopathy (MHE) impairs health-related quality of life and predicts overt hepatic encephalopathy (HE) in cirrhotic patients." | 5.35 | Predictors of nonresponse to lactulose for minimal hepatic encephalopathy in patients with cirrhosis. ( Sarin, SK; Sharma, BC; Sharma, P, 2009) |
| "The objective was to evaluate the efficacy and safety of sodium benzoate in the management of hyperammonemia and hepatic encephalopathy (HE) in decompensated chronic liver disease." | 5.34 | Efficacy and Safety of Sodium Benzoate in The Management of Hyperammonemia in Decompensated Chronic Liver Disease of the Childhood-A Double-blind Randomized Controlled Trial. ( Alam, S; Khanna, R; Lal, BB; Snehavardhan, P; Sood, V, 2020) |
| "Its role in acute hepatic failure (AHF) is controversial." | 5.32 | The effects of early and late administration of inhibitors of inducible nitric oxide synthase in a thioacetamide-induced model of acute hepatic failure in the rat. ( Hodgson, HJ; Rahman, TM, 2003) |
| "Chronic hepatic encephalopathy (CHE) is a disabling complication of chronic liver failure and porto-systemic shunt." | 5.31 | [Chronic hepatic encephalopathy: the role of high serum manganese levels and its relation with basal ganglia lesions in nuclear magnetic resonance of the brain. Clinical case]. ( Caballero, L; Miranda, M, 2001) |
| "HE in the presence of liver cirrhosis and/or portal-systemic shunting has been termed portal-systemic encephalopathy (PSE)." | 5.30 | Sleep disorders and portal-systemic encephalopathy following transjugular intrahepatic portosystemic stent shunt in patients with liver cirrhosis. Relation to plasma tryptophan. ( Bahn, E; Hajak, G; Nolte, W; Pilz, J; Ramadori, G; Rüther, E; von Heppe, J; Wiltfang, J, 1999) |
| "By contrast, rats with hepatic encephalopathy (HE) following administration of a hepatotoxin, thioacetamide, were characterized by CC edema and an increased Tau content in both BG and CC." | 5.29 | Relation of taurine transport and brain edema in rats with simple hyperammonemia or liver failure. ( Albrecht, J; Hilgier, W; Olson, JE, 1996) |
| "Hepatic encephalopathy (HE) is associated with elevated arterial ammonia levels." | 5.29 | Arterial ammonia with Blood Ammonia Checker II and with indophenol reaction to assess presence of hepatic encephalopathy. ( Gips, CH; Huizenga, JR; van Dam, GM, 1996) |
| "Intestinal mannitol is as effective and safe as conventional treatment for reducing hyperammonemia, oxidative stress, and hepatic encephalopathy of CLD patients in the emergency room." | 5.27 | Impact of intestinal mannitol on hyperammonemia, oxidative stress and severity of hepatic encephalopathy in the ED. ( Cruz-Domínguez, MP; Jara, LJ; Montes-Cortés, DH; Novelo-Del Valle, JL; Olivares-Corichi, IM; Rosas-Barrientos, JV, 2018) |
| " One group, termed stuporous (AS), received only enough ammonium acetate to interfere with grooming and exploratory activity; this dosage was insufficient to completely block the righting response, which was absent in the AC group." | 5.27 | Disruption of the blood-brain barrier in hyperammonemic coma and the pharmacologic effects of dexamethasone and difluoromethyl ornithine. ( Chandler, MD; McCandless, DW; Sears, ES, 1985) |
| "Lactulose is effective in secondary prophylaxis of hepatic encephalopathy (HE)." | 5.16 | Secondary prophylaxis of hepatic encephalopathy in cirrhosis: an open-label, randomized controlled trial of lactulose, probiotics, and no therapy. ( Agrawal, A; Sarin, SK; Sharma, BC; Sharma, P, 2012) |
| "To evaluate the influence of L-carnitine on mental conditions and ammonia effects on patients with hepatic encephalopathy (HE)." | 5.11 | Effects of L-carnitine in patients with hepatic encephalopathy. ( Elvira, R; Leotta, C; Liborio, R; Malaguarnera, M; Pistone, G; Scarpello, L, 2005) |
| "The efficacy and safety of rifaximin in comparison with lactitol in the treatment of acute hepatic encephalopathy was assessed in a prospective randomized, double-blind, double-dummy, controlled trial." | 5.10 | Comparison of rifaximin and lactitol in the treatment of acute hepatic encephalopathy: results of a randomized, double-blind, double-dummy, controlled clinical trial. ( Castells, L; Coll, I; Fernández-Rodríguez, C; Mas, A; Pardo, A; Planas, R; Rodés, J; Rodrigo, L; Rodríguez-Martínez, D; Sunyer, L; Vargas, V, 2003) |
| "To observe the long-term clinical efficacy of lactulose in patients with subclinical hepatic encephalopathy (SHE) and the natural history of this disease." | 5.10 | [Long-term efficacy of lactulose in patients with subclinical hepatic encephalopathy]. ( Dai, SJ; Li, YY; Nie, YQ; Ping, L; Sha, WH; Zeng, Z, 2003) |
| "To observe the natural history of subclinical hepatic encephalopathy (SHE) and to compare the efficacy of long-term and short-term treatment of lactulose." | 5.10 | [Effects of lactulose treatment on the course of subclinical hepatic encephalopathy]. ( Li, YY; Zeng, Z, 2003) |
| ", we determined the effect on chronic hepatic encephalopathy of long-term administration of Enterococcus faecium (SF68) versus lactulose." | 5.08 | Long-term effects of Enterococcus faecium SF68 versus lactulose in the treatment of patients with cirrhosis and grade 1-2 hepatic encephalopathy. ( Abbiati, R; Coltorti, M; Del Vecchio Blanco, C; Loguercio, C; Rinaldi, M; Romano, A, 1995) |
| "To investigate the efficacy and the acceptability of different doses of lactitol in patients with subclinical hepatic encephalopathy, 28 patients with cirrhosis were enrolled in a controlled clinical trial comparing 5-month therapies with lactitol at two different doses: 0." | 5.07 | Effects of long-term administration of low-dose lactitol in patients with cirrhosis but without overt encephalopathy. ( Benetti, G; Maggi, A; Moser, P; Salerno, F; Vitaliani, G, 1994) |
| "A cohort of 273 male patients enrolled in a Department of Veterans Affairs Cooperative Study performed to evaluate the efficacy of oxandrolone in combination with nutritional supplementation in moderate or severe alcoholic hepatitis." | 5.07 | Helicobacter pylori is a risk factor for hepatic encephalopathy in acute alcoholic hepatitis: the ammonia hypothesis revisited. The Veterans Administration Cooperative Study Group No. 275. ( Gubbins, GP; Marsano, LS; McClain, CJ; Mendenhall, CL; Moritz, TE; Talwalkar, R, 1993) |
| "We aimed to investigate the effect of L-carnitine on biochemical factors including ammonia, bilirubin, albumin, alanine aminotransferase, aspartate aminotransferase (AST), blood urea nitrogen (BUN), and creatinine (Cr) in patients with hepatic encephalopathy (HE)." | 5.01 | Effect of L-carnitine on liver enzymes and biochemical factors in hepatic encephalopathy: A systematic review and meta-analysis. ( Abbasnezhad, A; Alipour, M; Asbaghi, O; Choghakhori, R; Kashkooli, S; Mohammadi, R, 2019) |
| " Inflammation and manganese accumulation are also thought to be important in pathogenesis." | 4.95 | Hepatic Encephalopathy. ( Gow, AG, 2017) |
| " Recent studies provide new evidence for the use of lactulose, probiotics and rifaximin, as well as closure of large portosystemic shunts in the treatment of hepatic encephalopathy." | 4.90 | Treatment of hyperammonemia in liver failure. ( Jalan, R; Jover-Cobos, M; Khetan, V, 2014) |
| "The rationale for recommendation of branched-chain amino acids (BCAA; valine, leucine, and isoleucine) in treatment of liver failure is based on their unique pharmacologic properties, stimulatory effect on ammonia detoxification to glutamine (GLN), and decreased concentrations in liver cirrhosis." | 4.89 | Branched-chain amino acids and ammonia metabolism in liver disease: therapeutic implications. ( Holecek, M, 2013) |
| "Acute liver failure (ALF) is characterized neuropathologically by cytotoxic brain edema and biochemically by increased brain ammonia and its detoxification product, glutamine." | 4.88 | Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure: role of glutamine redefined. ( Butterworth, RF; Desjardins, P; Du, T; Jiang, W; Peng, L, 2012) |
| "To evaluate the clinical efficacy of lactulose in patients with minimal hepatic encephalopathy (MHE)." | 4.87 | Clinical efficacy and safety of lactulose for minimal hepatic encephalopathy: a meta-analysis. ( Cao, WK; Li, L; Lu, CZ; Luo, M, 2011) |
| "Lactulose is the most frequently utilized agent in the treatment of hepatic encephalopathy because of its efficacy and the fact that it has few serious side effects." | 4.79 | Lactulose and combination therapy of hepatic encephalopathy: the role of the intestinal microflora. ( Weber, FL, 1996) |
| "Lactulose is the most frequently utilized agent in the treatment of hepatic encephalopathy because of its efficacy and the fact that it has few serious side effects." | 4.79 | Effects of lactulose on nitrogen metabolism. ( Weber, FL, 1997) |
| "Relative deficiencies of ornithine or arginine occur in the presence of excessive ammonia, excessive lysine, growth, pregnancy, trauma, or protein deficiency and malnutrition." | 4.77 | Conditional deficiencies of ornithine or arginine. ( Zieve, L, 1986) |
| "This study was to investigate the effects of ammonia and manganese in the metabolism of minimal hepatic encephalopathy (MHE)." | 4.31 | The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study. ( Li, Y; Liu, XF; Lu, JJ; Qiang, JW; Yang, XY, 2023) |
| "L-Ornithine phenylacetate is an intravenous formulation of the L-ornithine salt of phenylacetic acid under development for the treatment of hepatic encephalopathy." | 4.12 | Population Pharmacokinetic Analysis to Assist Dose Selection of the L-Ornithine Salt of Phenylacetic Acid. ( Vilchez, RA; Wang, X, 2022) |
| "The objective of this study was to elucidate the effects of syringic acid on thioacetamide-induced hepatic encephalopathy which is a complex serious syndrome with neuropsychiatric abnormalities related to acute liver dysfunctions like cirrhosis." | 4.12 | Syringic acid protects against thioacetamide-induced hepatic encephalopathy: Behavioral, biochemical, and molecular evidence. ( Bayram, C; Ertugrul, MS; Ferah Okkay, I; Gundogdu, OL; Hacimuftuoglu, A; Mendil, AS; Okkay, U, 2022) |
| "This study aimed to investigate the possible usefulness of morin flavonoid in comparison to silymarin as a hepatic/neuronal-supportive agent with similar effects and higher bioavailability in a rat model of hepatic encephalopathy (HE)." | 4.12 | Molecular mechanisms involved in the effects of morin in experimental hepatic encephalopathy. ( Attia, AS; El-Ghazaly, MA; Rashed, ER; Shafey, GM; Zaki, HF, 2022) |
| "To investigate the metabolic changes in type C hepatic encephalopathy (CHE) rats after reducing manganese (Mn) intake." | 4.12 | Metabolic changes of the reduction of manganese intake in the hepatic encephalopathy rat: NMR- and MS-based metabolomics study. ( Li, Y; Lu, J; Qiang, J; Yang, X; Zhang, C, 2022) |
| "This study investigated the influence of chitosan oligosaccharides (COSs) on a thioacetamide-induced hepatic encephalopathy (HE) Wistar rat model." | 4.12 | Ameliorative Effect of Chitosan Oligosaccharides on Hepatic Encephalopathy by Reshaping Gut Microbiota and Gut-Liver Axis. ( Chen, L; Ge, Y; He, H; Li, X; Li, Z; Liu, Y; Luo, X; Ma, W; Qi, W; Wang, N; Wang, X; Zhang, T, 2022) |
| "Acetaminophen-induced hepatotoxicity can result in hyperammonemia, but it is not clear if elevated ammonia concentrations predict encephalopathy." | 4.12 | Hyperammonemia in acetaminophen toxicity. ( Marino, RT; Sidlak, AM, 2022) |
| "The aim of this study was to determine whether oral L-carnitine administration reduces the blood ammonia concentration and number of hospital admissions for hepatic encephalopathy in patients with advanced cirrhosis." | 4.02 | L-carnitine reduces hospital admissions in patients with hepatic encephalopathy. ( Fujita, K; Himoto, T; Kobara, H; Masaki, T; Mimura, S; Morishita, A; Nakahara, M; Nomura, T; Oura, K; Sakamoto, T; Tadokoro, T; Takuma, K; Tani, J; Yoneyama, H, 2021) |
| "Transmembrane pH gradient poly(isoprene)-block-poly(ethylene glycol) (PI-b-PEG) polymersomes were investigated for their potential use in the detoxification of ammonia, a metabolite that is excessively present in patients suffering from urea cycle disorders and advanced liver diseases, and which causes neurotoxic effects (e." | 3.96 | Ammonia uptake by transmembrane pH gradient poly(isoprene)-block-poly(ethylene glycol) polymersomes. ( Altmann, KH; Bao, Y; Hebels, ER; Leroux, JC; Schmidt, AC; Stoessel, B; Weitzel, C, 2020) |
| " The current investigation was designed to evaluate the role of taurine treatment on the brain and liver mitochondrial function in a rat model of hepatic encephalopathy and hyperammonemia." | 3.85 | Taurine treatment preserves brain and liver mitochondrial function in a rat model of fulminant hepatic failure and hyperammonemia. ( Abasvali, M; Abdoli, N; Asadi, B; Azarpira, N; Heidari, R; Jafari, F; Jamshidzadeh, A; Khodaei, F; Latifpour, Z; Mardani, E; Najibi, A; Ommati, MM; Yeganeh, Y; Zarei, A; Zarei, M, 2017) |
| "Brain manganese deposition is led by liver dysfunction and/or portal-systemic shunting in minimal hepatic encephalopathy (MHE)." | 3.85 | Reduction of manganese intake improves neuropsychological manifestations in rats with minimal hepatic encephalopathy. ( Ji, CX; Ju, S; Li, Y; Mei, LH; Qiang, JW, 2017) |
| " L-Carnitine is a vitamin-like substance and several reports have described the usefulness of L-carnitine supplementation in cases of cirrhosis, with confirmed effectiveness against refractory hepatic encephalopathy." | 3.81 | Usefulness of Levocarnitine and/or Branched-Chain Amino Acids during Invasive Treatment for Hepatocellular Carcinoma. ( Hasegawa, H; Ishihara, T; Iwasa, M; Kobayashi, Y; Mifuji-Moroka, R; Sekoguchi-Fujikawa, N; Sugimoto, R; Takei, Y; Tanaka, H; Yoshikawa, K, 2015) |
| "Increased brain lactate, and not glutamine, is a primary player in the pathogenesis of brain edema in CLD." | 3.80 | Increased brain lactate is central to the development of brain edema in rats with chronic liver disease. ( Bosoi, CR; Huynh, J; Marin, H; Parent-Robitaille, C; Rose, CF; Tremblay, M; Zwingmann, C, 2014) |
| "Ammonia production is implicated in the pathogenesis of hepatic encephalopathy (HE), being intestinal glutaminase activity the main source for ammonia." | 3.80 | THDP17 decreases ammonia production through glutaminase inhibition. A new drug for hepatic encephalopathy therapy. ( Bautista, J; Carbonero-Aguilar, P; del Campo, JA; Díaz-Herrero, MM; Iglesias-Guerra, F; Miñano, FJ; Periñán, I; Romero-Gómez, M; Vega-Pérez, JM, 2014) |
| "In cirrhotic patients, an oral glutamine load improves the psychometric diagnostic performance for minimal hepatic encephalopathy." | 3.79 | Oral glutamine challenge improves the performance of psychometric tests for the diagnosis of minimal hepatic encephalopathy in patients with liver cirrhosis. ( Cojocariu, C; Irimia, R; Sfarti, C; Stanciu, C; Trifan, A, 2013) |
| "Ornithine phenylacetate (OP) is a new drug that has been proposed for the treatment of hepatic encephalopathy (HE) because it decreases plasma ammonia." | 3.78 | Ornithine phenylacetate prevents disturbances of motor-evoked potentials induced by intestinal blood in rats with portacaval anastomosis. ( Arranz, JA; Córdoba, J; Oria, M; Raguer, N; Riudor, E; Romero-Giménez, J, 2012) |
| " Current knowledge suggests that hyperammonemia, related to liver failure, is a main factor contributing to the cerebral alterations in HE and that hyperammonemia might impair signal transduction associated with post-translational modification of proteins such as tyrosine-nitration and phosphorylation." | 3.78 | Exploratory investigation on nitro- and phospho-proteome cerebellum changes in hyperammonemia and hepatic encephalopathy rat models. ( Airoldi, L; Boix, J; Brunelli, L; Campagna, R; Cauli, O; Felipo, V; Llansola, M; Pastorelli, R, 2012) |
| "To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective cohort of diabetic cirrhotic patients." | 3.78 | Metformin inhibits glutaminase activity and protects against hepatic encephalopathy. ( Ampuero, J; Bautista, JD; Camacho, I; del Campo, JA; Díaz-Herrero, Mdel M; Figueruela, B; Maraver, M; Nuñez, D; Ranchal, I; Rojas, Á; Romero-Gómez, M, 2012) |
| "Patients with extrahepatic portal vein obstruction have inflammation and hyperammonemia made evident by higher blood TNF-α, IL-6, ammonia, and brain glutamine levels." | 3.77 | Pro-inflammatory cytokines are raised in extrahepatic portal venous obstruction, with minimal hepatic encephalopathy. ( Gupta, RK; Saraswat, VA; Srivastava, A; Thomas, MA; Yachha, SK; Yadav, SK, 2011) |
| "Intestinal bacteria metabolize tryptophan into indole, which is then further metabolized into oxindole, a sedative compound putatively involved in the pathophysiology of hepatic encephalopathy (HE)." | 3.76 | Peripheral and splanchnic indole and oxindole levels in cirrhotic patients: a study on the pathophysiology of hepatic encephalopathy. ( Angeloni, S; Carlà, V; Mannaioni, G; Merli, M; Moroni, F; Ridola, L; Riggio, O; Salvatori, FM, 2010) |
| " Significant decrease of myo-inositol in adults is probably due to cellular osmoregulation secondary to long-standing hyperammonemia." | 3.76 | Brain MR imaging and 1H-MR spectroscopy changes in patients with extrahepatic portal vein obstruction from early childhood to adulthood. ( Gupta, RK; Rathore, RK; Saksena, S; Saraswat, VA; Srivastava, A; Thomas, MA; Yadav, SK, 2010) |
| " The aim of this study was to assess the effects of simvastatin on rats with TAA-induced acute liver damage and hepatic encephalopathy." | 3.74 | Simvastatin for rats with thioacetamide-induced liver failure and encephalopathy. ( Chan, CY; Chang, FY; Chen, YC; Chu, CJ; Huang, HC; Lee, FY; Lee, SD; Lin, HC; Wang, SS, 2008) |
| " Solga, Probiotics can treat hepatic encephalopathy, Medical Hypotheses 2003; 61: 307-13), that probiotics are new therapeutics for hepatic encephalopathy (HE), and that they may replace antibiotics and lactulose." | 3.73 | Effect of antibiotics, prebiotics and probiotics in treatment for hepatic encephalopathy. ( Bongaerts, G; Severijnen, R; Timmerman, H, 2005) |
| "To compare the efficacy of probiotic preparation Golden Bifid and lactulose on rat experimental model of minimal hepatic encephalopathy (MHE) induced by thioactamide (TAA)." | 3.73 | Comparison of probiotics and lactulose in the treatment of minimal hepatic encephalopathy in rats. ( Jia, L; Zhang, MH, 2005) |
| "We treated a 49-yr-old man with neostigmine, who had liver cirrhosis, acute hepatic encephalopathy, and acute intestinal pseudoobstruction." | 3.73 | Neostigmine for the treatment of acute hepatic encephalopathy with acute intestinal pseudo-obstruction in a cirrhotic patient. ( Choi, SK; Joo, YE; Kim, HS; Kim, SJ; Park, CH; Rew, JS, 2005) |
| "To assess whether portacaval anastomosis (PCA) in rats affects the protein expression and/or activity of glutaminase in kidneys, intestines and in three brain areas of cortex, basal ganglia and cerebellum and to explain the neurological alterations found in hepatic encephalopathy (HE)." | 3.73 | Phosphate-activated glutaminase activity is enhanced in brain, intestine and kidneys of rats following portacaval anastomosis. ( Bautista, JD; Camacho, I; de Teran, LC; Diaz-Gomez, D; Echevarria, M; Felipo, V; Jover, M; Rodrigo, R; Romero-Gomez, M, 2006) |
| "Chronic methimazole treatment alleviates hepatic encephalopathy and liver damage in rats with BDL-induced hepatic cirrhosis." | 3.73 | Methimazole alleviates hepatic encephalopathy in bile-duct ligated cirrhotic rats. ( Chan, CY; Chang, CC; Chang, FY; Chen, YC; Huang, HC; Lee, FY; Lee, SD; Lin, HC; Wang, SS, 2006) |
| " We report a case of combined ecstasy/cocaine-induced fulminant hepatic failure presenting with severe rhabdomyolysis, myocardial infarction and multiorgan failure." | 3.72 | Successful treatment of refractory cerebral oedema in ecstasy/cocaine-induced fulminant hepatic failure using a new high-efficacy liver detoxification device (FPSA-Prometheus). ( Bauer, E; Kramer, L; Mallek, R; Schenk, P; Steininger, R; Vigl, M, 2003) |
| "We compared the effect of hyperammonemia on NADH levels in brain slices and on the rate of oxygen consumption from isolated nonsynaptic brain mitochondria in ammonia-sensitive Wistar rats with that in ammonia-tolerant gulf toadfish (Opsanus beta)." | 3.71 | Comparison of the effects of ammonia on brain mitochondrial function in rats and gulf toadfish. ( Pérez-Pinzón, MA; Veauvy, CM; Walsh, PJ; Wang, Y, 2002) |
| "We assessed the usefulness of oral glutamine challenge (OGC) and minimal hepatic encephalopathy in evaluating risk of overt hepatic encephalopathy in cirrhotic patients." | 3.71 | Altered response to oral glutamine challenge as prognostic factor for overt episodes in patients with minimal hepatic encephalopathy. ( Benitez, S; Camacho, I; Castro, M; Grande, L; Irles, JA; Romero-Gómez, M, 2002) |
| "Adult onset type II citrullinemia is an inherited disorder of amino acid metabolism caused by a deficiency of liver specific argininosuccinate synthetase activity." | 3.71 | Type II (adult onset) citrullinaemia: clinical pictures and the therapeutic effect of liver transplantation. ( Hashikura, Y; Ikeda, S; Ikegami, T; Iwai, M; Kawasaki, S; Kobayashi, K; Saheki, T; Takei, Y; Yazaki, M, 2001) |
| "Recent data from animal studies suggest that induced hypothyroidism prevents the hyperdynamic circulation in portal vein ligated rats, liver cirrhosis in rats chronically treated with thioacetamide (TAA), and immune-mediated acute liver injury induced in mice by concanavalin A." | 3.70 | Hypothyroidism minimizes liver damage and improves survival in rats with thioacetamide induced fulminant hepatic failure. ( Aeed, H; Avni, Y; Bruck, R; Halpern, Z; Matas, Z; Oren, R; Papa, M; Shirin, H; Zaidel, L, 1998) |
| "Therapeutic modulation of the increased GABAergic tone in chronic hepatic encephalopathy (HE) by the benzodiazepine receptor (BR) antagonist flumazenil (F) has led to conflicting results in humans and animal models for HE." | 3.70 | Improvement of chronic hepatic encephalopathy in dogs by the benzodiazepine-receptor partial inverse agonist sarmazenil, but not by the antagonist flumazenil. ( Legemate, DA; Meyer, HP; Rothuizen, J; van den Brom, W, 1998) |
| "The administration of sodium benzoate provides an alternative pathway for the disposal of waste nitrogen and this substance has been used to treat patients with urea cycle defects and more recently cirrhotics with hepatic encephalopathy." | 3.70 | Effect of sodium benzoate on blood ammonia response to oral glutamine challenge in cirrhotic patients: a note of caution. ( Efrati, C; Masini, A; Merli, M; Riggio, O; Valeriano, V, 2000) |
| "Intracerebral microdialysis was applied to monitor the neocortical extracellular levels of the aromatic amino acids phenylalanine, tyrosine, and tryptophan, the neurotransmitters dopamine (DA), noradrenaline (NA), and serotonin (5-HT), and the metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindole-3-acetic acid (5-HIAA) in rats with various forms of experimental hepatic encephalopathy (HE)." | 3.69 | Neocortical dialysate monoamines of rats after acute, subacute, and chronic liver shunt. ( Bengtsson, F; Bergqvist, PB; Bosman, DK; Chamuleau, RA; Hjorth, S; Maas, MA; Vogels, BA, 1995) |
| "Lactitol, a non-absorbable synthetic disaccharide, was administered at a dose of 36g/day for 3-4 weeks to 8 patients with liver cirrhosis and hepatic encephalopathy in order to investigate its effects on fecal bacterial flora and clinical symptoms of hepatic encephalopathy." | 3.69 | [Effects of lactitol on fecal bacterial flora in patients with liver cirrhosis and hepatic encephalopathy]. ( Hayashi, M; Ito, Y; Okawa, S; Tamai, S; Tarao, K, 1995) |
| "High affinity [3H]gamma-aminobutyric acid (GABA) and [3H]L-glutamate uptake were determined in synaptosomes prepared from the cerebral cortex of dogs with congenital hepatic encephalopathy and control dogs." | 3.69 | L-glutamate and gamma-aminobutyric acid uptake in synaptosomes from the cerebral cortex of dogs with congenital chronic hepatic encephalopathy. ( Johnston, GA; Maddison, JE; Watson, WE, 1995) |
| "We successfully anesthetized a 53-year-old female with hypercitrullinemia and severe liver cirrhosis." | 3.69 | [Anesthetic management for a patient with citrullinemia and liver cirrhosis]. ( Igarashi, M; Iwasaki, H; Kawana, S; Namiki, A, 1995) |
| "We investigated the role of brain peripheral-type benzodiazepine receptors (PBRs) and pregnenolone (a product of PBRs activation) in hepatic encephalopathy (HE)/hyperammonemia." | 3.69 | Acute liver failure and hyperammonemia increase peripheral-type benzodiazepine receptor binding and pregnenolone synthesis in mouse brain. ( Dombro, RS; Itzhak, Y; Norenberg, MD; Roig-Cantisano, A, 1995) |
| "Brain myo-inositol, an organic osmolyte, is decreased in cirrhotic patients with hepatic encephalopathy but appears unchanged in fulminant hepatic failure." | 3.69 | Glutamine, myo-inositol, and organic brain osmolytes after portocaval anastomosis in the rat: implications for ammonia-induced brain edema. ( Blei, AT; Cordoba, J; Gottstein, J, 1996) |
| "Correlation among in vivo glutamine synthetase (GS) activity, brain ammonia and glutamine concentrations, and severity of encephalopathy was examined in hyperammonemic rats to obtain quantitative information on the capacity of GS to control these metabolites implicated in the etiology of hepatic encephalopathy." | 3.69 | Severity of hyperammonemic encephalopathy correlates with brain ammonia level and saturation of glutamine synthetase in vivo. ( Chung, JC; Kanamori, K; Kuo, EL; Ross, BD, 1996) |
| "The effects of hepatic encephalopathy (HE) due to thioacetamide (TAA)-induced liver failure and hyperammonemia (HA) produced by repeated i." | 3.68 | Hyperammonemia and hepatic encephalopathy stimulate rat cerebral synaptic mitochondrial glutamate dehydrogenase activity specifically in the direction of glutamate oxidation. ( Albrecht, J; Faff-Michalak, L, 1993) |
| " On the diagnosis of hypothalamic hypothyroidism, she was treated with levothyroxine sodium." | 3.68 | Portal-systemic encephalopathy and hypothalamic hypothyroidism: effect of thyroid hormone on ammonia metabolism. ( Hitoshi, S; Sakuta, M; Terao, Y, 1993) |
| "Most of the brain glycogen, a major energy reserve that can be mobilized in response to increased neuronal activity, resides in the astrocyte, the site of the neuropathological abnormality found in hepatic encephalopathy (HE)." | 3.68 | The action of ammonia on astrocyte glycogen and glycogenolysis. ( Dombro, RS; Hutson, DG; Norenberg, MD, 1993) |
| "Levels of cholecystokinin (CCK) immunoreactivity and distribution of CCK immunoreactive cells were studied in the cerebral cortex of LEC (Long Evans Cinnamon) rats with hepatic encephalopathy." | 3.68 | Reduced cholecystokinin in the brain of LEC rats with hepatic encephalopathy. ( Kobayashi, H; Madarame, T; Matsuoka, Y; Miura, Y; Sato, S; Suzuki, K; Takeichi, N; Tateishi, K; Yoshida, T, 1991) |
| "The possible involvement of taurine in the pathogenesis of hepatic encephalopathy was studied in rats injected with thioacetamide." | 3.68 | Taurine release from brain slices in thioacetamide-induced hepatic encephalopathy in rats. ( Oja, SS; Saransaari, P; Wysmyk, U, 1991) |
| " The concentrations of methanethiol-mixed disulfides, methionine, 4-methylthio-2-oxobutyrate and ammonia were measured in patients with different stages of hepatic encephalopathy, in patients with chronic kidney failure and in healthy subjects." | 3.68 | The role of methanethiol in the pathogenesis of hepatic encephalopathy. ( Blom, HJ; Ferenci, P; Grimm, G; Tangerman, A; Yap, SH, 1991) |
| "Significant elevation of glutamic acid and glutamine concentrations in CSF was observed in hepatic encephalopathic patients with fulminant hepatitis and liver cirrhosis." | 3.67 | Glutamic acid and glutamine levels in serum and cerebrospinal fluid in hepatic encephalopathy. ( Fujiwara, M; Higashi, T; Nagashima, H; Nakatsukasa, H; Sakata, T; Shiota, T; Takei, N; Watanabe, A, 1984) |
| " Plasma concentrations of amino acids, octopamine, and ammonia were assayed in order to document the metabolic change of hepatic encephalopathy." | 3.67 | Visual evoked potential: a diagnostic tool for the assessment of hepatic encephalopathy. ( Gollini, G; Messori, E; Penne, A; Pinelli, G; Ventura, E; Zani, G; Zeneroli, ML, 1984) |
| "To assess neuronal mechanisms of potential importance in the pathogenesis of hepatic encephalopathy, visual evoked potentials were recorded in rabbits with acute hyperammonemic encephalopathy, postictal coma, and toxin-induced coma resulting from the administration of a combination of subcoma doses of three neurotoxins: ammonia, dimethyldisulfide, and octanoic acid." | 3.67 | Visual evoked potentials in a rabbit model of hepatic encephalopathy. II. Comparison of hyperammonemic encephalopathy, postictal coma, and coma induced by synergistic neurotoxins. ( Ferenci, P; Jones, EA; Pappas, SC; Schafer, DF, 1984) |
| "To obtain a more precise pathophysiological evaluation of the role of ammonia in acute hepatic encephalopathy, we compared the plasma ammonia concentrations and electroencephalographic recordings (EEGs) of rabbits with surgically induced acute hepatic failure (AHF, n = 10) and normal rabbits administered an infusion of ammonium acetate (NH4-Ac, n = 7) over a 10-hr period." | 3.67 | Continuous intravenous ammonia infusion as a model for the study of hepatic encephalopathy in rabbits. ( de Vlieger, M; Fick, TE; Schalm, SW, 1989) |
| "Cerebral blood flow (CBF), measured by the noninvasive xenon-133 inhalation method, EEG, and plasma levels of ammonia (NH3) and free tryptophan were determined in 18 hospitalized cirrhotic patients affected with subclinical hepatic encephalopathy, as diagnosed by the Kurtz test." | 3.67 | Reduction of cerebral blood flow in subclinical hepatic encephalopathy and its correlation with plasma-free tryptophan. ( Celle, G; Gris, A; Marenco, S; Nobili, F; Novellone, G; Rodriguez, G; Rosadini, G; Testa, R, 1987) |
| "In fourteen subjects with various stages of hepatic encephalopathy (HE), Visual Evoked Potential (VEP) recording and blood ammonia (NH3), octopamine (OCT) and phenylethanolamine (PEA) determinations were performed before and during a four-day treatment with branched chain amino acid (BCAA) i." | 3.67 | Visual evoked potential recordings in hepatic encephalopathy and their variations during branched chain amino-acid treatment. ( Bernardi, L; Bombardieri, G; Ferri, R; Gigli, GL; Grassi, C; Milani, A, 1985) |
| "Lactulose is currently the drug of choice for the treatment of hepatic encephalopathy." | 3.67 | Lactitol in the treatment of chronic hepatic encephalopathy: an open comparison with lactulose. ( Lanthier, PL; Morgan, MY, 1985) |
| " For this purpose in 30 patients with liver cirrhosis the time in the NCT was determined and the serum ammonia level (NH3) was measured before the treatment with lactulose and neomycin was started." | 3.67 | [Ambulatory diagnosis and therapy control of portasystemic encephalopathy in patients with liver cirrhosis]. ( Haerting, J; Mantel, E; Nilius, R; Rink, C, 1985) |
| "Hepatic encephalopathy in patients with severe liver disease was associated with marked elevation of either serum methionine or blood ammonia levels or with simultaneous moderate increases in both parameters." | 3.66 | Impaired metabolism of methionine in severe liver diseases. II. Clinical and experimental studies on role of impaired methionine metabolism in pathogenesis of hepatic encephalopathy. ( Higashi, T, 1982) |
| "Metabolic observations during early stages of hyperammonemia in two infants with ornithine transcarbamylase deficiency suggest that plasma alpha-ketoglutarate concentration ([alpha-KG]) becomes subnormal before the development of hyperammonemic coma." | 3.66 | Plasma alpha-ketoglutarate in urea cycle enzymopathies and its role as a harbinger of hyperammonemic coma. ( Batshaw, ML; Brusilow, SW; Walser, M, 1980) |
| "It has been recently proposed that hepatic encephalopathy could be due to the accumulation of octopamine acting as a false neurotransmitter, and the increase of ammonia might reflect this accumulation." | 3.65 | Octopamine and ammonia plasma levels in hepatic encephalopathy. ( Angelico, M; Attili, AF; Cangiano, C; Capocaccia, L; Cascino, A; Rossi Fanelli, F, 1977) |
| " The potential development of hepatic encephalopathy was evaluated by serial determinations of serum ammonia and the biogenic amine, octopamine, which correlated well with the patient's clinical state." | 3.65 | Serum polyamine and octopamine changes following partial hepatectomy and portacaval shunt. ( Garnica, AD; Monson, RC; Rodgers, BM; Talbert, JL, 1977) |
| "The aim of this study was to specify the mechanism of hepatic encephalopathy which may occur in some cirrhotics treated by Spironolactone." | 3.65 | [Hyperammonemia and hepatic encephalopathy in cirrhotics receiving spironolactone (author's transl)]. ( Imler, M; Schlienger, JL, 1977) |
| "To evaluate the role of tyramine in hepatic disorders, we used a radioimmunoassay to study plasma concentration of tyramine in eight healthy subjects, 20 hospitalized patients without liver disease, and 13 cirrhotic patients of whom seven had hepatic encephalopathy." | 3.65 | Hypertyraminemia in cirrhotic patients. ( Bowen, PA; Faraj, BA; Isaacs, JW; Rudman, D, 1976) |
| "Thirteen dogs with hepatic encephalopathy were found to have hyperammonemia and increased retention of plasma sulfobromophthalein." | 3.65 | Hyperammonemia and hepatic encephalopathy in the dog. ( Kaneko, JJ; Strombeck, KR; Weiser, MG, 1975) |
| "Minimal hepatic encephalopathy (MHE) reflects cognitive impairment in patients with liver cirrhosis and is associated with poor prognosis." | 3.30 | Nutritional therapy for persistent cognitive impairment after resolution of overt hepatic encephalopathy in patients with cirrhosis: A double-blind randomized controlled trial. ( Bara, S; Dalal, A; Kumar, A; Mahajan, B; Maharshi, S; Sachdeva, S; Sharma, A; Sharma, BC; Sonika, U; Srivastava, S, 2023) |
| " Plasma levels of ornithine and phenylacetic acid (PAA) and plasma/urinary levels of phenylacetylglutamine (PAGN) (primary metabolite of PAA) were regularly assessed; plasma ammonia level was the primary pharmacodynamic variable." | 3.11 | Pharmacokinetics/pharmacodynamics of L-ornithine phenylacetate in overt hepatic encephalopathy and the effect of plasma ammonia concentration reduction on clinical outcomes. ( Bajaj, JS; Bukofzer, S; Devarakonda, KR; Jamil, K; Potthoff, A; Pyrsopoulos, N; Rahimi, RS; Ram Bhamidimarri, K; Safadi, R; Thabut, D; Wang, L, 2022) |
| "There is no study on the prevention of recurrence of encephalopathy with L-ornithine L-aspartate (LOLA)." | 2.87 | Secondary prophylaxis of hepatic encephalopathy in cirrhosis of liver: a double-blind randomized controlled trial of L-ornithine L-aspartate versus placebo. ( Dahale, AS; Sachdeva, S; Sharma, BC; Srivastava, S; Varakanahalli, S, 2018) |
| "pylori eradication in the treatment of hepatic encephalopathy in patients with LC is unlikely to occur." | 2.82 | Prevalence of Helicobacter pylori Infection in Patients with Minimal Hepatic Encephalopathy. ( Malfertheiner, P; Reisener, N; Schulz, C; Schütte, K; Voss, J, 2016) |
| "Minimal hepatic encephalopathy (MHE) represents the mildest form of hepatic encephalopathy (HE), with abnormal neuropsychologic findings." | 2.78 | Serum endotoxin, inflammatory mediators, and magnetic resonance spectroscopy before and after treatment in patients with minimal hepatic encephalopathy. ( Jain, L; Puri, SK; Sarin, S; Sharma, BC; Sharma, P; Srivastava, S, 2013) |
| "Minimal hepatic encephalopathy (MHE) is diagnosed when hepatic patients perform worse on psychometric tests compared to healthy controls." | 2.78 | Can Lactobacillus acidophilus improve minimal hepatic encephalopathy? A neurometabolite study using magnetic resonance spectroscopy. ( El Yamany, SA; Hamisa, MF; Hasan, AM; Soliman, HH; Ziada, DH, 2013) |
| "Minimal hepatic encephalopathy (MHE) is one of the possible complications of liver cirrhosis." | 2.78 | Treatment with a potassium-iron-phosphate-citrate complex improves PSE scores and quality of life in patients with minimal hepatic encephalopathy: a multicenter, randomized, placebo-controlled, double-blind clinical trial. ( Biedermann, A; Burkard, T; Diefenbach, M; Dietlein, M; Herold, C; Rauch, M, 2013) |
| "Patients with cirrhosis and minimal hepatic encephalopathy (MHE) have driving difficulties but the effects of therapy on driving performance is unclear." | 2.76 | Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy. ( Bajaj, JS; Bell, DE; Fuchs, M; Gibson, DP; Hafeezullah, M; Heuman, DM; Luketic, V; Saeian, K; Sanyal, AJ; Sterling, RK; Stravitz, RT; Wade, JB; Wegelin, JA, 2011) |
| "Fatigue is frequently reported in hepatic encephalopathy (HE) and may be related to hyperammonemia." | 2.76 | Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. ( Bella, R; Galvano, F; Giordano, M; Li Volti, G; Malaguarnera, M; Pennisi, G; Rampello, L; Vacante, M, 2011) |
| "minimal hepatic encephalopathy with malnutrition can be given a diet of 35-40 cal/kgBW and 1." | 2.76 | The effect of L-ornithine L-aspartate and branch chain amino acids on encephalopathy and nutritional status in liver cirrhosis with malnutrition. ( Hasan, I; Ndraha, S; Simadibrata, M, 2011) |
| "pylori infection in causation of minimal hepatic encephalopathy (MHE) has not been well studied." | 2.76 | Role of Helicobacter pylori infection in the pathogenesis of minimal hepatic encephalopathy and effect of its eradication. ( Agrawal, A; Chandra, M; Gupta, A; Koowar, S, 2011) |
| "Minimal hepatic encephalopathy (MHE) impairs daily functioning and health-related quality of life (HRQoL)." | 2.76 | A randomized controlled trial comparing lactulose, probiotics, and L-ornithine L-aspartate in treatment of minimal hepatic encephalopathy. ( Mittal, VV; Sarin, SK; Sharma, BC; Sharma, P, 2011) |
| "61 patients with severe hepatic encephalopathy were recruited to the study." | 2.76 | Acetyl-L-carnitine improves cognitive functions in severe hepatic encephalopathy: a randomized and controlled clinical trial. ( Bella, R; Giordano, M; Malaguarnera, G; Malaguarnera, M; Motta, M; Nunnari, G; Pennisi, G; Rampello, L; Vacante, M, 2011) |
| "Minimal hepatic encephalopathy (HE) is associated with poorer quality of life and increased work disability." | 2.73 | Value of the apparent diffusion coefficient for quantification of low-grade hepatic encephalopathy. ( Fujita, N; Iwasa, M; Kaito, M; Kobayashi, Y; Maeda, M; Sugimoto, R; Takeda, K; Takei, Y; Tanaka, H; Urawa, N, 2008) |
| "Minimal hepatic encephalopathy (MHE), the preclinical stage of overt hepatic encephalopathy (OHE), is a significant condition affecting up to 60% of cirrhotics." | 2.73 | Probiotic yogurt for the treatment of minimal hepatic encephalopathy. ( Bajaj, JS; Binion, DG; Christensen, KM; Franco, J; Hafeezullah, M; Hoffmann, RG; Krakower, G; Pleuss, JA; Saeian, K; Varma, RR, 2008) |
| "Minimal hepatic encephalopathy (MHE) is common in cirrhosis but its pathophysiologic basis remains undefined." | 2.73 | Role of ammonia and inflammation in minimal hepatic encephalopathy. ( Jalan, R; Olde Damink, SW; Shawcross, DL; Wright, G, 2007) |
| "The pathogenesis of hepatic encephalopathy is controversial although ammonia has been found to induce cerebral dysfunction." | 2.73 | Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. ( Barone, G; Gargante, MP; Greco, F; Malaguarnera, M; Toscano, MA, 2007) |
| "The severity of hepatic encephalopathy is currently graded clinically using West Haven criteria and psychometric tests." | 2.73 | Sensitivity and specificity of bispectral index for classification of overt hepatic encephalopathy: a multicentre, observer blinded, validation study. ( Bao, FP; Bornemann, H; Dahaba, AA; Metzler, H; Rehak, PH; Salah, A; Stadlbauer, V; Stauber, RE; Worm, HC; Zakaria, S; Zhu, SM, 2008) |
| "Minimal hepatic encephalopathy was diagnosed with the Trail Making Test (TMT), Symbol Digit Modalities Test (SDMT) and Auditory Verbal Learning Test (AVL) and cognitive function with the Mini Mental State Examination (MMSE)." | 2.73 | Acetyl-L-carnitine treatment in minimal hepatic encephalopathy. ( Cammalleri, L; Cristaldi, E; Gargante, MP; Malaguarnera, M; Pennisi, G; Rampello, L; Risino, C; Vacante, M, 2008) |
| "Minimal hepatic encephalopathy (MHE) is associated with poor quality of life and increased work disability." | 2.73 | An open-label randomized controlled trial of lactulose and probiotics in the treatment of minimal hepatic encephalopathy. ( Puri, V; Sarin, SK; Sharma, BC; Sharma, P, 2008) |
| "The pathogenesis of hepatic encephalopathy (HE) is controversial." | 2.72 | Amino acid challenge in patients with cirrhosis and control subjects: ammonia, plasma amino acid and EEG changes. ( Al Mardini, H; Douglass, A; Record, C, 2006) |
| "L: -Acetylcarnitine (LAC) is a physiologically active substance that improves both the energetic and the neurotransmission profiles." | 2.72 | Effects of L-acetylcarnitine on cirrhotic patients with hepatic coma: randomized double-blind, placebo-controlled trial. ( Astuto, M; Lo Giudice, E; Malaguarnera, M; Pistone, G; Raffaele, R; Rampello, L; Vecchio, I, 2006) |
| "The diagnosis of hepatic encephalopathy was based on clinical criteria, and the severity of hepatic encephalopathy was based on the West Haven Criteria for grading of mental status." | 2.71 | Correlation between ammonia levels and the severity of hepatic encephalopathy. ( Aggarwal, A; Arroliga, AC; Easley, KA; Karafa, MT; Krieger, D; Mullen, KD; Ong, JP; Van Lente, F, 2003) |
| "Hepatic encephalopathy is a frequent complication of cirrhosis." | 2.71 | Oral tryptophan challenge studies in cirrhotic patients: no evidence of neuropsychiatric changes. ( Al Mardini, H; Douglass, A; Record, CO, 2003) |
| "Minimal hepatic encephalopathy (MHE) is an important disorder that may seriously impair daily functioning and quality of life in patients with cirrhosis." | 2.71 | Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis. ( Bengmark, S; Duan, ZP; Ha, DK; Kurtovic, J; Liu, Q; Riordan, SM, 2004) |
| "The outcome of hepatic encephalopathy was not significantly different between both groups of treatment." | 2.71 | Normal protein diet for episodic hepatic encephalopathy: results of a randomized study. ( Castro, F; Córdoba, J; Esteban, R; Guardia, J; López-Hellín, J; Planas, M; Sabín, P; Sanpedro, F, 2004) |
| "Patients with acute liver failure were treated with an ECHS device utilizing continuous hemodiafiltration with continuous albumin dialysis." | 2.70 | Results of a phase I trial evaluating a liver support device utilizing albumin dialysis. ( Awad, SS; Bartlett, RH; Magee, J; Punch, J; Swaniker, F, 2001) |
| " The patients were treated for 15 consecutive days with rifaximin, an antibiotic which is not absorbed by the intestinal wall, at a dosage of 1200 mg/day in association with sufficient lactulose to induce 2 or 3 evacuations per day." | 2.68 | Rifaximin in the treatment of chronic hepatic encephalopathy. ( Ferrieri, A; Massimetti, A; Puxeddu, A; Quartini, M, 1995) |
| "When propranolol was administered to patients with alcoholic cirrhosis and marginal liver function, as reflected by ammonia levels above 60 microM, it caused a significant increase in ammonia levels in arterialized-venous and arterial, but not in venous, blood (p less than 0." | 2.66 | Venous, arterial, and arterialized-venous blood ammonia levels and their relationship to hepatic encephalopathy after propranolol. ( Lieber, CS; Snady, H, 1988) |
| " In addition, branched chain amino acids or casein in a dosage of 0." | 2.66 | [Branched-chain amino acids in the treatment of latent porto-systemic encephalopathy. A placebo-controlled double-blind cross-over study]. ( Egberts, EH; Hamster, W; Jürgens, P; Schomerus, H, 1986) |
| "Acute hepatic encephalopathy in 70 cirrhotic patients was monitored during parenteral administration of amino acids between January 1979 and January 1984." | 2.66 | Treatment of acute hepatic encephalopathy in cirrhotics with a branched-chain amino acids enriched versus a conventional amino acids mixture. A controlled study of 70 patients. ( Aubin, JP; Bauret, P; Bellet-Herman, H; Bories, P; Michel, H; Pomier-Layrargues, G, 1985) |
| "Ampicillin was tested with regards to its capacity to reduce gastric ammonia production in basal and betazole-stimulated gastric secretion." | 2.64 | Reduction of gastric ammonia by ampicillin in normal and azotemic subjects. ( Lieber, CS; Meyers, S, 1976) |
| "Hepatic encephalopathy is a neuropsychological syndrome due to biochemical disturbance of brain function in advanced liver disease patients." | 2.61 | Mechanistic insight, diagnosis, and treatment of ammonia-induced hepatic encephalopathy. ( Fiati Kenston, SS; Li, Z; Song, X; Zhao, J, 2019) |
| "Sarcopenia was positively associated with the presence of HE (OR 2." | 2.61 | Is sarcopenia associated with hepatic encephalopathy in liver cirrhosis? A systematic review and meta-analysis. ( Chang, KV; Chen, JD; Han, DS; Huang, KC; Lin, HY; Wu, WT, 2019) |
| "Hepatic encephalopathy is a common and devastating neuropsychiatric complication of acute liver failure or chronic liver disease." | 2.61 | Acetyl-L-carnitine for patients with hepatic encephalopathy. ( Arevalo-Rodriguez, I; Gluud, C; Martí-Amarista, CE; Martí-Carvajal, AJ, 2019) |
| "Neuropathology of hepatic encephalopathy (HE) in cirrhosis is primarily astroglial in nature characterized by Alzheimer type 2 astrocytosis together with activation of microglia indicative of neuroinflammation." | 2.61 | Hepatic Encephalopathy in Cirrhosis: Pathology and Pathophysiology. ( Butterworth, RF, 2019) |
| "Hepatic encephalopathy is one of the most debilitating clinical manifestations of cirrhosis and associated with increased morbidity and mortality." | 2.61 | Updates on the pathophysiology and therapeutic targets for hepatic encephalopathy. ( Alsahhar, JS; Rahimi, RS, 2019) |
| "Minimal hepatic encephalopathy (MHE) is an early and reversible form of hepatic encephalopathy." | 2.58 | Effect of probiotic treatment on cirrhotic patients with minimal hepatic encephalopathy: A meta-analysis. ( Cao, HC; Cao, Q; Chen, P; Deng, M; Li, LJ; Yang, SG; Yu, CB, 2018) |
| "Minimal hepatic encephalopathy (MHE) is the earliest form of HE and is estimated to affect more that 75% of patients with liver cirrhosis." | 2.53 | Hepatic encephalopathy: Ever closer to its big bang. ( Marcotegui, AR; Orbea, L; Perazzo, JC; Skerl, J; Souto, PA, 2016) |
| "To compare interventions in terms of patients' adverse events and major clinical outcomes." | 2.52 | Systematic review with network meta-analysis: the comparative effectiveness and safety of interventions in patients with overt hepatic encephalopathy. ( Braddock, M; Chen, YP; Huang, GQ; Huang, S; Lin, YQ; Shi, KQ; Wang, LR; Zheng, MH; Zhu, GQ, 2015) |
| "Search terms included hepatic encephalopathy, ammonia hypothesis, brain and ammonia, liver failure and ammonia, acute-on-chronic liver failure and ammonia, cirrhosis and ammonia, portosytemic shunt, ammonia and lactulose, rifaximin, zinc, and nutrition." | 2.52 | Refining the ammonia hypothesis: a physiology-driven approach to the treatment of hepatic encephalopathy. ( Jiang, ZG; Patwardhan, VR; Tapper, EB, 2015) |
| "Minimal hepatic encephalopathy (mHE) is common among patients with cirrhotic liver disease and causes significant morbidity and mortality." | 2.52 | Diagnosis and Treatment of Low-Grade Hepatic Encephalopathy. ( Direkze, S; Jalan, R, 2015) |
| "The diagnosis of hepatic encephalopathy is predominantly clinical, and the tests available assist in the diagnosis only by excluding other causes." | 2.52 | New Methods of Testing and Brain Imaging in Hepatic Encephalopathy: A Review. ( Edula, RG; Pyrsopoulos, NT, 2015) |
| "Hyperammonemia is necessary for development of the cerebral complications to liver disease including hepatic encephalopathy and cerebral edema but the mechanisms are unclear." | 2.50 | Cerebral effects of ammonia in liver disease: current hypotheses. ( Ott, P; Vilstrup, H, 2014) |
| "Most treatments of hyperammonemia target the organs and metabolic processes involved in ammonia detoxification." | 2.50 | Pharmacotherapy for hyperammonemia. ( Hadjihambi, A; Jalan, R; Khetan, V, 2014) |
| "Hepatic encephalopathy is a neuropsychiatric complication of liver cirrhosis the symptoms of which may vary from imperceptible to severe, invaliding, and even lethal." | 2.50 | Concise review of current concepts on nomenclature and pathophysiology of hepatic encephalopathy. ( Liakina, V; Savlan, I; Valantinas, J, 2014) |
| "Recently, inflammation has also been identified as a contributor to HE." | 2.50 | Pathophysiology, diagnosis, and management of hepatic encephalopathy. ( Lu, L; Patel, A; Sheasgreen, C, 2014) |
| "We review PET- and MR studies on hepatic encephalopathy (HE) metabolism in human subjects from the point of views of methods, methodological assumptions and use in studies of cirrhotic patients with clinically overt HE, cirrhotic patients with minimal HE, cirrhotic patients with no history of HE and healthy subjects." | 2.49 | Brain metabolism in patients with hepatic encephalopathy studied by PET and MR. ( Keiding, S; Pavese, N, 2013) |
| "Patients with liver cirrhosis frequently lack sufficient BCAAs and therefore suffer from various metabolic disorders." | 2.49 | Effects of oral branched-chain amino acids on hepatic encephalopathy and outcome in patients with liver cirrhosis. ( Kawaguchi, T; Sata, M; Taniguchi, E, 2013) |
| "Hyperammonemia in end-stage acute liver failure (ALF) is often associated with cerebral edema and astrocyte pathology/swelling." | 2.49 | Possible treatment of end-stage hyperammonemic encephalopathy by inhibition of glutamine synthetase. ( Cooper, AJ, 2013) |
| "Infection and inflammation have been associated with the development of delirium for many centuries and there is a rapidly growing evidence base supporting the role of inflammation in exacerbating the neurological manifestations of both acute and chronic liver failure." | 2.49 | Systemic inflammation and ammonia in hepatic encephalopathy. ( Ryan, JM; Shawcross, DL; Tranah, TH; Vijay, GK, 2013) |
| "Hepatic encephalopathy is a medical phenomenon that is described as a neuropsychiatric manifestation of chronic or acute liver disease that is characterized by psychomotor, intellectual and cognitive abnormalities with emotional/affective and behavioral disturbances." | 2.49 | Current pathogenetic aspects of hepatic encephalopathy and noncirrhotic hyperammonemic encephalopathy. ( Cichoż-Lach, H; Michalak, A, 2013) |
| "Hepatic encephalopathy is a serious and potentially fatal complication of both acute and chronic liver disease, arising as a result of hepatocellular failure, cirrhosis and/or portal-systemic shunting (Ferenci et al, 2002)." | 2.48 | Hepatic encephalopathy. ( Cobbold, JF; McPhail, MJ; Patel, D; Taylor-Robinson, SD, 2012) |
| "Hepatic encephalopathy is a complex and potentially reversible neuropsychiatric syndrome complicating acute or chronic liver disease." | 2.47 | Hepatic encephalopathy: from pathophysiology to therapeutic management. ( Bismuth, M; Blanc, P; Cadranel, JF; Funakoshi, N, 2011) |
| "Patients with hepatic encephalopathy exhibit sings of energy impairment that may participate in the development of disturbances in neurotransmission." | 2.47 | Acute-on-chronic liver failure: the brain. ( Córdoba, J; García-Martínez, R, 2011) |
| "Hepatic encephalopathy is a neuropsychiatric syndrome associated with liver failure." | 2.47 | To pee or not to pee: ammonia hypothesis of hepatic encephalopathy revisited. ( Dejong, CH; Jalan, R; Mpabanzi, L; Olde Damink, SW; Soeters, PB; van de Poll, MC, 2011) |
| "Introduction." | 2.47 | Critical analysis of studies evaluating the efficacy of infusion of L-ornithine L-aspartate in clinical hepatic encephalopathy in patients with liver failure. ( Abdo Francis, JM; Higuera de la Tijera, F; Pérez Hernández, JL; Serralde-Zúñiga, AE, 2011) |
| "Hepatic encephalopathy is a common metabolic condition in children, having a significantly different aetiopathogenesis from that in adults." | 2.46 | Management of hepatic encephalopathy in children. ( Arya, R; Deopujari, S; Gulati, S, 2010) |
| "Hepatic encephalopathy is a syndrome whose pathophysiology is poorly understood, for which we lack high-quality diagnostic tests and markers, and whose treatment has improved only slightly over the last several decades." | 2.46 | Hepatic encephalopathy: current management strategies and treatment, including management and monitoring of cerebral edema and intracranial hypertension in fulminant hepatic failure. ( O'connor, M; Zafirova, Z, 2010) |
| "Hepatic encephalopathy is a clinical diagnosis, and several scoring systems have been used to determine the severity of hepatic encephalopathy." | 2.46 | Clinical management of hepatic encephalopathy. ( Schiano, TD, 2010) |
| " Although dosages have varied, most medical centers use a dosage of rifaximin 400 mg 3 times/day for hepatic encephalopathy." | 2.46 | Treatment options for hepatic encephalopathy. ( Schiano, TD, 2010) |
| "Subclinical hepatic encephalopathy (SHE) is a serious clinical problem in patiens with liver damage and precise pathophisiological mechanisms resonsible for encephalopathy are not fully understood." | 2.46 | [Pathogenesis and diagnosis of subclinical hepatic encephalopathy]. ( Ciećko-Michalska, I; Mach, T; Słowik, A, 2010) |
| "The face of hepatic encephalopathy (HE) is changing." | 2.46 | Changing face of hepatic encephalopathy: role of inflammation and oxidative stress. ( Hughes, RD; Seyan, AS; Shawcross, DL, 2010) |
| "Acute liver failure is a rare disorder with high mortality and resource cost." | 2.46 | Acute liver failure. ( Auzinger, G; Bernal, W; Dhawan, A; Wendon, J, 2010) |
| "Systemic hyperammonemia has been largely found in patients with cirrhosis and hepatic encephalopathy, and ammonia plays a major role in the pathogenesis of hepatic encephalopathy." | 2.45 | Gut ammonia production and its modulation. ( Galán, JJ; Jover, M; Romero-Gómez, M; Ruiz, A, 2009) |
| "Mechanisms involved in hepatic encephalopathy (HE) still remain poorly understood." | 2.45 | Signaling factors in the mechanism of ammonia neurotoxicity. ( Jayakumar, AR; Norenberg, MD; Rama Rao, KV, 2009) |
| "Hepatic encephalopathy is characterized by neuropsychiatric abnormalities in patients with liver failure." | 2.45 | Hepatic encephalopathy: pathophysiology and emerging therapies. ( Shaikh, OS; Sundaram, V, 2009) |
| "The currently accepted regimens to treat hepatic encephalopathy such as lactulose and protein restricted diets need further clinical trials and therefore placebo controlled clinical trials in hepatic encephalopathy are justified." | 2.44 | Management of hepatic encephalopathy in patients with cirrhosis. ( Jalan, R; Wright, G, 2007) |
| "The aetiology of hepatic encephalopathy has not been conclusively established, but it is widely agreed that ammonia derived primarily from enteric bacterial flora plays a central role." | 2.44 | Review article: bacterial flora and pathogenesis in hepatic encephalopathy. ( Williams, R, 2007) |
| "Mechanical hyperventilation has a prompt effect on intracranial pressure." | 2.44 | The effect of hyperventilation upon cerebral blood flow and metabolism in patients with fulminant hepatic failure. ( Strauss, GI, 2007) |
| "Hepatic encephalopathy is a severe complication of cirrhosis that is related to the effects of ammonia." | 2.44 | Hepatic encephalopathy. ( Córdoba, J; Mínguez, B, 2008) |
| " We also propose a mechanism by which glutamine executes its toxic effects in astrocytes, the "Trojan horse" hypothesis." | 2.43 | Glutamine: a Trojan horse in ammonia neurotoxicity. ( Albrecht, J; Norenberg, MD, 2006) |
| "Distinct syndromes are identified in acute liver failure and cirrhosis." | 2.42 | The molecular pathogenesis of hepatic encephalopathy. ( Davies, N; Jalan, R; Shawcross, D, 2003) |
| "Comparison of HE in acute liver failure (ALF) with that of cirrhosis allows recognition of important differences and similarities." | 2.42 | Pathogenesis of hepatic encephalopathy in acute liver failure. ( Blei, AT; Cahill, ME; Chung, C; Vaquero, J, 2003) |
| "The diagnosis of hepatic encephalopathy (HE) is based mostly on clinical criteria." | 2.42 | Assessing the severity of hepatic encephalopathy. ( Chandy, GM; Peter, S; Venkataraman, S, 2003) |
| "Hepatic encephalopathy has been linked to H." | 2.42 | Helicobacter pylori and hepatic encephalopathy. ( Chawla, YK; Dhiman, RK; Duseja, A; Sachdev, A, 2003) |
| "Sodium benzoate is an alternate method of nonbacterial, non-hepatic metabolic binding pathway for ammonia disposal." | 2.42 | Role of gut bacteria in the therapy of hepatic encephalopathy with lactulose and antibiotics. ( Dasarathy, S, 2003) |
| "Hepatic encephalopathy is frequently, though not always, accompanied by elevated blood ammonia level." | 2.42 | [Ammonia and GABA-ergic neurotransmission in pathogenesis of hepatic encephalopathy]. ( Helewski, K; Konecki, J; Kowalczyk-Ziomek, G, 2003) |
| "The pathogenesis of hepatic encephalopathy (HE) remains elusive." | 2.42 | Oxidative stress in the pathogenesis of hepatic encephalopathy. ( Jayakumar, AR; Norenberg, MD; Rama Rao, KV, 2004) |
| "Hyperammonemia is mainly found in hepatic encephalopathy and in genetic defects of the urea cycle or other pathways of the intermediary metabolism." | 2.41 | Mechanisms of hyperammonemia. ( Bachmann, C, 2002) |
| "Fulminant hepatic failure is a life-threatening clinical syndrome following severe hepatic injury leading to cerebral edema and brainstem herniation." | 2.41 | Extracorporeal treatment in fulminant hepatic failure: pathophysiologic considerations. ( Bauer, E; Kramer, L, 2002) |
| "There appears to be a consensus that hepatic encephalopathy (HE) is a metabolic encephalopathy with a multifactorial pathogenesis." | 2.41 | Ammonia, the GABA neurotransmitter system, and hepatic encephalopathy. ( Jones, EA, 2002) |
| "Hepatic encephalopathy is considered to be a reversible metabolic encephalopathy, which occurs as a complication of hepatocellular failure and is associated with increased portal-systemic shunting of gut-derived nitrogenous compounds." | 2.41 | Pathogenesis of hepatic encephalopathy. ( Jones, EA, 2000) |
| "Cerebral edema and hepatic encephalopathy are major complications of acute liver failure." | 2.41 | Alterations in expression of genes coding for key astrocytic proteins in acute liver failure. ( Bélanger, M; Butterworth, RF; Desjardins, P, 2001) |
| "Early theories or hepatic encephalopathy focused on ammonia-driven disruption of the Krebs cycle and cellular energy production." | 2.41 | Branched chain amino acids in heptatic encephalopathy. ( James, JH, 2002) |
| "While the pathogenesis of hepatic encephalopathy (HE) remains elusive, there is considerable evidence pointing to a key role of ammonia-induced dysfunction of astrocytes in this condition." | 2.40 | Astroglial dysfunction in hepatic encephalopathy. ( Norenberg, MD, 1998) |
| "In regards to hepatic encephalopathy, however, the CCl4 cirrhosis rat model seems to display few behavioral changes unless very advanced decompensated cirrhosis is produced." | 2.39 | Animal models of hepatic encephalopathy and hyperammonemia. ( Birgisson, S; Conjeevaram, H; Gacad, RC; Mullen, KD, 1994) |
| "The tremor was postural and intentional, and extremely increased at the end point." | 2.39 | [A case of portal-systemic encephalopathy with slowly progressive, non-flapping tremor]. ( Kurokawa, K; Nakamura, S; Oue, Y; Sakata, C; Sudoh, S, 1995) |
| "The syndrome of minimal hepatic encephalopathy is used to describe discrete psychomental and neuro-psychological abnormalities in patients with chronic liver disease (cirrhosis) or portosystemic shunt, in whom classical clinical investigations reveal no evidence of mental or cerebro-neurological disorders, and who cannot be assigned to any of the usual stages of hepatic encephalopathy." | 2.39 | [Hepatic minimal encephalopathy. The most frequently overlooked, clinically occult "metabolic syndrome" on the cirrhosis patient]. ( Eisenburg, J, 1996) |
| "The treatment of hepatic encephalopathy is predominantly an empirical approach because the process pathogenesis of this syndrome is uncertain." | 2.39 | Treatment of hepatic encephalopathy in patients with cirrhosis of the liver. ( Ferenci, P, 1996) |
| "Hepatic encephalopathy is a neuropsyquiatric syndrome associated to multifactorial metabolic disruptions." | 2.38 | [Pathogenesis of portal systemic encephalopathy]. ( Barragán, RF; García Compeán, D; Valadez Castillo, R, 1990) |
| " These data indicate the feasibility of utilization of carnitine in the therapy of human hyperammonemic syndromes, both for reducing the levels of ammonia and preventing its toxic effects." | 2.38 | New roles of carnitine metabolism in ammonia cytotoxicity. ( Costell, M; O'Connor, JE, 1990) |
| "The definition of hepatic coma has been used for the most severe course of hepatic insufficiency, independent from the pathogenesis." | 2.36 | [On the neuro-psychiatric symptomatology of the so-called "hepatic coma" (author's transl)]. ( Binder, H, 1981) |
| "Serum ammonia testing in hepatic encephalopathy (HE) has been long debated in the field of hepatology." | 1.91 | The Ongoing Debate of Serum Ammonia Levels in Cirrhosis: the Good, the Bad, and the Ugly. ( Deutsch-Link, S; Moon, AM, 2023) |
| "Objective Rifaximin is used to treat hepatic encephalopathy." | 1.91 | Add-on Therapeutic Effects of Rifaximin on Treatment-resistant Hepatic Encephalopathy. ( Hayakawa, Y; Higuchi, M; Inada, K; Ishido, S; Izumi, N; Kakegawa, T; Kaneko, S; Kirino, S; Kurosaki, M; Maeyashiki, C; Matsumoto, H; Nakanishi, H; Nobusawa, T; Okamoto, R; Takahashi, Y; Takaura, K; Tamaki, N; Tanaka, S; Tanaka, Y; Tsuchiya, K; Yamashita, K; Yasui, Y, 2023) |
| "Recurrent hepatic encephalopathy (HE) is characterized by hyperammonaemia in combination with neuropsychiatric abnormalities and is treated with lactulose and rifaximin." | 1.91 | Rifaximin stimulates nitrogen detoxification by PXR-independent mechanisms in human small intestinal organoids. ( Beuers, U; de Wit, K; Gulersonmez, MC; Middendorp, S; Mukha, A; Ramos Pittol, JM; Stigter, ECA; Takkenberg, RB; van Mil, SWC, 2023) |
| "In patients with hepatic encephalopathy, GABA+ levels in the cerebello-thalamo-cortical loop are significantly increased in the cerebellum and significantly decreased in the motor cortex." | 1.91 | J-difference GABA-edited MRS reveals altered cerebello-thalamo-cortical metabolism in patients with hepatic encephalopathy. ( Ahn, S; Butz, M; Füllenbach, ND; Häussinger, D; Jördens, MS; Ljimani, A; Oeltzschner, G; Schnitzler, A; Thiel, TA; Wilms, LM; Wittsack, HJ; Zöllner, HJ, 2023) |
| "Hepatic encephalopathy was rapidly improved by percutaneous transhepatic portosystemic shunt obliteration." | 1.91 | [A Case of Perihilar Cholangiocarcinoma with Postoperative Hepatic Encephalopathy Due to Portosystemic Shunt Treated by Percutaneous Embolization]. ( Hike, S; Hosokawa, I; Koda, K; Kosugi, C; Murakami, T; Nojima, H; Ohno, T; Shimizu, H; Shuto, K; Usui, A; Yamazaki, M; Yogi, N, 2023) |
| "Hepatic encephalopathy is a confusional state associated with cirrhosis." | 1.91 | Serum ammonia does not guide management and is overutilised in patients with cirrhosis in hospital settings. ( Al-Ani, A; Hannah, N; Hebbard, G; Kansal, A; Sood, S; Vasic, D, 2023) |
| "The prevalence of minimal hepatic encephalopathy (MHE), in particular in different subgroups, remains unknown." | 1.91 | Prevalence of Minimal Hepatic Encephalopathy in Patients With Liver Cirrhosis: A Multicenter Study. ( Bloom, PP; Danneberg, S; Ehrenbauer, AF; Gabriel, M; Gairing, SJ; Galle, PR; Gioia, S; Labenz, C; Labenz, J; Lauridsen, MM; Lok, AS; Mangini, C; Marquardt, JU; Montagnese, S; Nardelli, S; Nielsen, EJ; Ripoll, C; Sultanik, P; Thabut, D; Weissenborn, K; Zarantonello, L; Zipprich, A, 2023) |
| "Liver dysfunction is the main cause of hepatic encephalopathy." | 1.91 | Severe Acute Liver Dysfunction Induces Delayed Hepatocyte Swelling and Cytoplasmic Vacuolization, and Delayed Cortical Neuronal Cell Death. ( Itakura, Y; Kawakami, K; Mita, H; Nakadate, K; Sono, C, 2023) |
| "PARTO and CARTO were performed to treat hepatic encephalopathy via the 2 splenorenal shunts." | 1.91 | Simultaneous use of plug-assisted and coil-assisted retrograde transvenous obliteration for treating refractory hepatic encephalopathy in a patient with two portosystemic shunts: A case report. ( Ju, SG; Lee, JM; Shim, J, 2023) |
| "Psychometric hepatic encephalopathy score (PHES) <-4 or critical flicker frequency (CFF) <39 was considered abnormal." | 1.91 | Development and validation of the AMMON-OHE model to predict risk of overt hepatic encephalopathy occurrence in outpatients with cirrhosis. ( Ampuero, J; Balcar, L; Ballester, MP; Carbonell-Asins, JA; Escudero, MD; Fiorillo, A; Jalan, R; Kerbert, AJC; Mandorfer, M; Montoliu, C; Reiberger, T; Romero-Gómez, M; Shawcross, DL; Thomsen, KL; Tranah, TH, 2023) |
| "But although the drugs developed to treat hyperammonemia resulting from urea cycle disorders were successfully developed and approved by the FDA, the compound suggested as a treatment for hepatic encephalopathy was unable to attract sufficient interest and investment to be tested for use in humans." | 1.72 | Saul Brusilow: Understanding and treating diseases of ammonia toxicity. ( Brusilow, WSA, 2022) |
| "Hyperlipidemia and oxidative stress with elevated oxidized low-density lipoprotein (ox-LDL) exacerbate hepatic inflammation and fibrosis." | 1.72 | Effects of PCSK-9 Inhibition by Alirocumab Treatments on Biliary Cirrhotic Rats. ( Chang, CC; Chuang, CL; Hou, MC; Hsu, SJ; Huang, HC; Lee, FY, 2022) |
| "The most prevalent UCD detected were ornithine transcarbamylase deficiency, followed by citrullinemia type 1, hyperargininemia, carbamoyl phosphate synthase 1 deficiency, and argininosuccinic aciduria." | 1.72 | Clinical findings of patients with hyperammonemia affected by urea cycle disorders with hepatic encephalopathy. ( de Moura Coelho, D; Dos Reis, BG; Faverzani, JL; Lopes, FF; Ribas, GS; Sitta, A; Vargas, CR; Wajner, M, 2022) |
| "Results: An improved rate of overt hepatic encephalopathy (HE) of 82." | 1.72 | Long-Term Effects of Rifaximin on Patients with Hepatic Encephalopathy: Its Possible Effects on the Improvement in the Blood Ammonia Concentration Levels, Hepatic Spare Ability and Refractory Ascites. ( Fukuda, H; Fukunaga, A; Higashi, M; Higashi, T; Hirai, F; Miyayama, T; Sakisaka, S; Shakado, S; Shibata, K; Takata, K; Tanaka, T; Tsuchiya, N; Uchida, Y; Umeda, K; Yamauchi, R; Yokoyama, K, 2022) |
| "The pathophysiology of hepatic encephalopathy (HE) is incompletely understood." | 1.72 | Elevation of Autoantibodies to Cerebral Proteins in Hepatic Encephalopathy: Another Pathogenic Factor? ( Falalyeyeva, TM; Manzhalii, EG; Moyseyenko, VO; Stremmel, W; Weiskirchen, R, 2022) |
| "We evaluated the dynamics of hepatic encephalopathy (HE) and ammonia estimation in acute-on-chronic liver failure (ACLF) patients due to a paucity of evidence." | 1.62 | Dynamic assessments of hepatic encephalopathy and ammonia levels predict mortality in acute-on-chronic liver failure. ( Al Mahtab, M; Arora, A; Butt, AS; Choudhury, A; Devarbhavi, H; Dhiman, RK; Dokmeci, AK; Duseja, A; Eapen, CE; Ghazinyan, H; Goel, A; Goyal, O; Hamid, SS; Hu, J; Jafri, W; Kim, DJ; Kulkarni, A; Kumar, A; Kumar, R; Lau, GK; Lee, GH; Lesmana, LA; Midha, V; Ning, Q; Payawal, DA; Prasad, VGM; Rao, PN; Sahu, M; Sarin, SK; Shah, S; Shaojie, X; Shresta, A; Shukla, A; Singh, A; Singh, V; Sollano, J; Sood, A; Tan, SS; Taneja, S; Tao, H; Treeprasertsuk, S; Verma, N; Yuemin, N; Zhongping, D, 2021) |
| "Ammonia levels are used to assess hepatic encephalopathy, but their levels are highly variable in clinical practice." | 1.56 | Variability and Lability of Ammonia Levels in Healthy Volunteers and Patients With Cirrhosis: Implications for Trial Design and Clinical Practice. ( Anderson, C; Bajaj, JS; Blankstein, L; Bloom, PP; Brennan, AM; Chung, RT; Denney, WS; Gavis, EA; Hassanein, TI; Kayali, Z; Lawitz, E; Lee, WM; Muthukumar, AR; Padilla-Martinez, M; Puurunen, MK; Rockey, DC; Sasso, R, 2020) |
| "Malondialdehyde (MDA) in HV was 6." | 1.56 | Characterization of Oxidative Stress and Ammonia According to the Different Grades of Hepatic Encephalopathy. ( Cruz-Dominguez, MDP; Hernández-López, JC; Manuel-Apolinar, L; Martìnez-Godinez, MLA; Montes-Cortes, DH; Olivares-Corichi, IM; Rosas-Barrientos, JV, 2020) |
| "Inflammation is likely an important target of BBD to treat HE." | 1.56 | BabaoDan cures hepatic encephalopathy by decreasing ammonia levels and alleviating inflammation in rats. ( An, YT; Bahaji Azami, NL; Lu, BJ; Lu, L; Sun, MY; Wang, HJ; Wang, Z; Wu, C; Xie, D; Ye, G, 2020) |
| "Hyperammonemia is one of the contributing factors of hepatic encephalopathy (HE)." | 1.56 | Comparative accuracy and precision of two commercial laboratory analyzers for the quantification of ammonia in cerebrospinal fluid. ( Bhatti, SFM; de Rooster, H; Devriendt, N; Meyer, E; Or, M; Paepe, D; Vallarino, N, 2020) |
| "Hepatic encephalopathy is a clinical diagnosis." | 1.56 | Low-Value Levels: Ammonia Testing Does Not Improve the Outcomes of Overt Hepatic Encephalopathy. ( Rahimi, RS; Tapper, EB, 2020) |
| "The current therapies for hepatic encephalopathy (HE) are not completely effective in all patients, probably due to the physiopathological heterogeneity and the different conditions underlying the bout of HE." | 1.56 | Oral glutamine challenge is a marker of altered ammonia metabolism and predicts the risk of hepatic encephalopathy. ( Ampuero, J; Camacho, I; Gil, A; Millán, R; Rico, MC; Romero-Gómez, M; Viloria, MDM, 2020) |
| "Hepatic myelopathy or spastic paraparesis of liver disease is an insidious onset condition with pure motor spastic paraparesis without sensory, bladder or bowel involvement in patients with chronic liver disease, in which the neurological dysfunction cannot be explained by other causes." | 1.56 | Spastic paraparesis associated with advanced liver cirrhosis: a condition obscure in terms of treatment and prognosis. ( Gupta, M; Jesrani, G; Kaur, J; Lehl, SS, 2020) |
| "Management of hepatic encephalopathy (HE) remains challenging from a medical and psychosocial perspective." | 1.56 | Important Unresolved Questions in the Management of Hepatic Encephalopathy: An ISHEN Consensus. ( Bajaj, JS; Dhiman, RK; Duarte-Rojo, A; Lauridsen, M; Montagnese, S; Rahimi, RS; Romero-Gomez, M; Sharma, BC; Shawcross, DL; Tandon, P; Tapper, EB; Thabut, D, 2020) |
| "Conclusion Rifaximin administration for hepatic encephalopathy improved the CONUT and ALBI scores." | 1.56 | Changes in the Body Composition and Nutritional Status after Long-term Rifaximin Therapy for Hyperammonemia in Japanese Patients with Hepatic Encephalopathy. ( Azumi, M; Endo, S; Honma, T; Imai, M; Ishikawa, T; Iwanaga, A; Nozawa, Y; Sano, T; Yoshida, T, 2020) |
| "Minimal hepatic encephalopathy (MHE) is a subclinical complication of liver cirrhosis with a relevant social impact." | 1.51 | Minimal Hepatic Encephalopathy is Associated with Increased Cerebral Vascular Resistance. A Transcranial Doppler Ultrasound Study. ( Ainora, ME; Caracciolo, G; Funaro, B; Garcovich, M; Gasbarrini, A; Lupascu, A; Nesci, A; Pompili, M; Ponziani, FR; Quadarella, A; Riccardi, L; Zocco, MA, 2019) |
| "Psychometric Hepatic Encephalopathy Score (PHES) and ammonia improved significantly in the patients with amelioration in SMI >10% (n = 16) and not in those without (n = 11) (PHES: -1." | 1.51 | The modification of quantity and quality of muscle mass improves the cognitive impairment after TIPS. ( Gioia, S; Lattanzi, B; Merli, M; Nardelli, S; Pitocchi, F; Ridola, L; Riggio, O, 2019) |
| "Minimal hepatic encephalopathy is associated with an increased risk of mortality in patients with liver cirrhosis, independent of hepatocellular carcinoma stage or Child-Pugh score." | 1.51 | Prognostic significance of minimal hepatic encephalopathy in patients with liver cirrhosis in Japan: A propensity score-matching analysis. ( Hanai, T; Imai, K; Moriwaki, H; Shimizu, M; Shiraki, M; Suetsugu, A; Takai, K; Watanabe, S, 2019) |
| "To report a successfully treated hyperammonemia due to a portosystemic shunt in adult patient." | 1.51 | Acute hyperammonemic encephalopathy due to a portosystemic shunt in a non-cirrhotic adult patient. ( Ezquerro-Sáenz, S; Fuster-Cabré, M; Lapetra-Labé, AM; Medrano-Peña, J; Requena-Calleja, MÁ, 2019) |
| "Acute hepatic encephalopathy has significant morbidity and mortality in liver transplant recipients unless it is promptly treated." | 1.48 | Brain MRI findings in acute hepatic encephalopathy in liver transplant recipients. ( Chen, SQ; Guo, RM; Guo, Y; Jiao, J; Li, QL; Wang, J; Zhang, Y; Zhong, LR, 2018) |
| "Minimal hepatic encephalopathy (MHE) has been reported in children with extrahepatic portal vein obstruction (EHPVO)." | 1.48 | Stroop Test Validation to Screen for Minimal Hepatic Encephalopathy in Pediatric Extrahepatic Portal Venous Obstruction. ( Jagadisan, B; Kandasamy, P; Senthilkumar, GP; Suresh, MV, 2018) |
| "metformin was associated with a significant inhibition of glutaminase activity levels in the small intestine of porto-caval shunted rats (0." | 1.48 | Metformin modifies glutamine metabolism in an in vitro and in vivo model of hepatic encephalopathy. ( Ampuero, J; Gallego-Durán, R; García-Valdecasas, M; Gil-GÓmez, A; Gómez-Sotelo, AI; Muñoz-Hernández, R; Ranchal, I; Rojas, Á; Romero Gómez, M, 2018) |
| "Hepatic encephalopathy was defined by either a hepatic encephalopathy-related hospitalization and/or taking ammonia-lowering treatment (i." | 1.48 | Myosteatosis and sarcopenia are associated with hepatic encephalopathy in patients with cirrhosis. ( Bhanji, RA; Duarte-Rojo, A; Ebadi, M; Ghosh, S; Moctezuma-Velazquez, C; Montano-Loza, AJ; Rose, C, 2018) |
| "Minimal hepatic encephalopathy (MHE), a complex neuropsychological complication of cirrhosis, is characterized by delayed reaction time and the inhibition of abnormal response." | 1.48 | Efficacy of different drugs in the treatment of minimal hepatic encephalopathy: A network meta-analysis involving 826 patients based on 10 randomized controlled trials. ( Cai, XJ; Hu, CM; Wang, L, 2018) |
| "Hepatic encephalopathy is a major complication in patients with advanced cirrhosis and is associated with poor prognosis." | 1.48 | L-Carnitine for the Treatment of Overt Hepatic Encephalopathy in Patients with Advanced Liver Cirrhosis. ( Futsukaichi, Y; Kobayashi, S; Minemura, M; Sugiyama, T; Tajiri, K; Takahara, T; Yasumura, S, 2018) |
| "Treatment with rutin resulted in improvement in liver function by the decline in serum AST and ALT activities and reduction in serum ammonia level." | 1.46 | Ameliorative effects of rutin on hepatic encephalopathy-induced by thioacetamide or gamma irradiation. ( El-Marakby, SM; Mansour, SZ; Moawed, FSM, 2017) |
| "Minimal hepatic encephalopathy is associated with poor prognosis and mortality in patients with cirrhosis." | 1.46 | Lactulose reduces bacterial DNA translocation, which worsens neurocognitive shape in cirrhotic patients with minimal hepatic encephalopathy. ( Ampuero, J; Bellot, P; Figueruela, B; Francés, R; Gallego-Durán, R; González-Navajas, JM; Martínez-Moreno, B; Moratalla, A; Roger, M; Romero-Gómez, M; Such, J; Zapater, P, 2017) |
| "Muscle mass loss and hepatic encephalopathy (complex neuropsychiatric disorder) are serious complications of chronic liver disease (cirrhosis) which impact negatively on clinical outcome and quality of life and increase mortality." | 1.46 | The bile duct ligated rat: A relevant model to study muscle mass loss in cirrhosis. ( Bemeur, C; Bosoi, CR; Deutz, NE; Ochoa-Sanchez, R; Oliveira, MM; Rose, CF; Ten Have, GA; Tremblay, M, 2017) |
| "The pathogenesis of hepatic encephalopathy (HE) in cirrhosis is multifactorial and ammonia is thought to play a key role." | 1.46 | Ammonia mediates cortical hemichannel dysfunction in rodent models of chronic liver disease. ( Davies, N; De Chiara, F; Gourine, AV; Habtetion, A; Hadjihambi, A; Hosford, PS; Jalan, R; Karagiannis, A, 2017) |
| "MHE was diagnosed with psychometric hepatic encephalopathy score (PHES) ≤ -5." | 1.46 | Sleep disturbances in patients of liver cirrhosis with minimal hepatic encephalopathy before and after lactulose therapy. ( Puri, V; Sachdeva, S; Sharma, BC; Singh, J; Srivastava, S, 2017) |
| "Portal hypertension affects portal-systemic shunt which leads to hepatic encephalopathy that the vascular modulation might influence severity of hepatic encephalopathy." | 1.46 | Effects of raloxifene on portal hypertension and hepatic encephalopathy in cirrhotic rats. ( Chang, CC; Chang, T; Chuang, CL; Hsin, IF; Hsu, SJ; Huang, HC; Lee, FY; Lee, SD; Lee, WS, 2017) |
| "2." | 1.43 | Evaluation of mid- and long-term efficacy of shunt limiting for hepatic myelopathy after transjugular intrahepatic portosystemic shunt. ( Fan, Z; Liu, F; Wang, L; Yue, Z; Zhao, H, 2016) |
| "EASL/AASLD hepatic encephalopathy (HE) guidelines proposed the alternative use of the term 'Covert HE' combining minimal HE (mHE) and Grade 1 HE into a single entity." | 1.43 | Clinical and Pathophysiological Characteristics of Cirrhotic Patients with Grade 1 and Minimal Hepatic Encephalopathy. ( Jalan, R; Macnaughtan, J; Mookerjee, RP; Thomsen, KL; Tritto, G, 2016) |
| "She was diagnosed with liver cirrhosis as a result of autoimmune hepatitis, combined with Sjögren's syndrome." | 1.43 | Gradual improvement of hyperammonemic hepatic encephalopathy after the extirpation of a large uterine leiomyoma in a woman with constipation and liver cirrhosis resulting from autoimmune hepatitis. ( Himeno, R; Kunitomo, K; Matsumoto, S; Ohkuchi, A; Sakamoto, T; Wada, M, 2016) |
| " Rifaximin, a poorly absorbed antibiotic that targets gut flora, significantly improved symptoms of HE." | 1.43 | Development of an experimental rat model of hyperammonemic encephalopathy and evaluation of the effects of rifaximin. ( Fukui, N; Isobe, M; Okada, M; Saito, T; Suzuki, H; Tamaoki, S, 2016) |
| "BACKGROUND Acute liver failure (ALF) is an emergent condition that requires intensive care and manifests in particular by significant elevation in serum ammonia level." | 1.43 | Ammonia Level and Mortality in Acute Liver Failure: A Single-Center Experience. ( Alachkar, N; Alqahtani, S; Araz, F; Cameron, AM; Gurakar, A; Niranjan-Azadi, AM; Patel, YA; Stevens, RD, 2016) |
| "Dogs treated for hepatic encephalopathy prior to hospital admission were significantly less likely to have clinical signs of the disease at hospital admission, compared with dogs that were not treated for the disease (OR, 0." | 1.42 | Putative precipitating factors for hepatic encephalopathy in dogs: 118 cases (1991-2014). ( Ivanek, R; Lidbury, JA; Steiner, JM; Suchodolski, JS, 2015) |
| "Spironolactone is an aldosterone receptor antagonist used to control fluid overload in cirrhotic patients although recent studies suggest that it also inhibits angiogenesis." | 1.42 | The Impact of Spironolactone on the Severity of Portal-Systemic Collaterals and Hepatic Encephalopathy in Cirrhotic Rats. ( Chang, CC; Ho, HL; Hsin, IF; Hsu, SJ; Huang, HC; Huo, TI; Lee, FY; Lee, SD; Lin, HC; Wang, SS, 2015) |
| "Subjects with hepatic coma showed significant difference in endozepine-4 (P < 0." | 1.42 | Endozepine-4 levels are increased in hepatic coma. ( Bertino, G; Drago, F; Giordano, M; Malaguarnera, G; Malaguarnera, M; Motta, M; Vacante, M, 2015) |
| "Hepatic encephalopathy is associated with a regional specific decrease of GABA levels in the visual cortex, while no changes were revealed for the sensorimotor cortex." | 1.42 | Low visual cortex GABA levels in hepatic encephalopathy: links to blood ammonia, critical flicker frequency, and brain osmolytes. ( Baumgarten, TJ; Butz, M; Hoogenboom, N; Oeltzschner, G; Schnitzler, A; Wittsack, HJ, 2015) |
| "Hepatic encephalopathy is a result of insufficient liver function, with grave consequences for the patients." | 1.42 | [Options in the treatment of hepatic encephalopathy]. ( Petersen, KU, 2015) |
| "Because fulminant Wilson disease (WD) has an extremely poor prognosis, the use of liver support that can bridge patients to liver transplantation is lifesaving." | 1.40 | Effect of molecular adsorbents recirculating system treatment in children with acute liver failure caused by Wilson disease. ( Boillot, O; Bordet, F; Bost, M; Brunet, AS; Cour-Andlauer, F; Javouhey, E; Lachaux, A; Richard, N; Rustom, N; Valla, F, 2014) |
| "Thirty-seven patients with SRS due to liver cirrhosis were included in this study." | 1.40 | Relationships between splenorenal shunt/portal vein diameter ratio and systemic hemodynamics in patients with liver cirrhosis. ( Chikamori, F; Kuniyoshi, N; Okamoto, H, 2014) |
| "A total of 135 patients with liver cirrhosis and HE had serum ammonia levels measured on admission." | 1.40 | Ammonia levels and the severity of hepatic encephalopathy. ( Khokhar, N; Qureshi, MO; Shafqat, F, 2014) |
| "Chronic hepatic encephalopathy (CHE) is a major complication in patients with severe liver disease." | 1.40 | Decreased astrocytic thrombospondin-1 secretion after chronic ammonia treatment reduces the level of synaptic proteins: in vitro and in vivo studies. ( Abuzamel, M; Curtis, KM; Gaidosh, G; Jayakumar, AR; Johnstone, J; Norenberg, MD; Rama Rao, KV; Ruiz-Cordero, R; Shamaladevi, N; Tong, XY, 2014) |
| "Dimethyl maleate induced an increase in ROS and MDA in the blood, but not in the brain, of the PCA rats, compared with non-treated PCA rats." | 1.40 | Induction of systemic oxidative stress leads to brain oedema in portacaval shunted rats. ( Bosoi, CR; Rose, CF; Tremblay, M, 2014) |
| "The data on the positive experience with hepatic encephalopathy in patients with cirrhosis liver L-ornithine-L-aspartate (drug larnamyn), the effectiveness of which is provided by its components (amino acids, ornithine and aspartate) which improve metabolism, ammonia detoxification mechanism, production of energy in the Krebs cycle, promote restoration of the cell membrane, and carried out anti-inflammatory and detoxicative effect." | 1.40 | [Pathogenesis, diagnosis and treatment of hepatic encephalopathies in patients with liver cirrhosis]. ( Manzhaliĭ, EH; Moĭseienko, VO; Nykula, TD; Solonovych, OS, 2014) |
| "Of the 23 patients studied, 3 developed hepatic encephalopathy." | 1.39 | [Analysis of L-asparaginase induced elevation of blood ammonia and hepatic encephalopathy]. ( Cen, XN; Li, Y; Liang, ZY; Ren, HY; Yin, Y, 2013) |
| "Furthermore, the severity of liver cirrhosis, determined by Child-Pugh scores, correlated with serum IL-6 levels (r=0." | 1.39 | Correlation between interleukin-6 and ammonia in patients with overt hepatic encephalopathy due to cirrhosis. ( Cao, WK; Dai, CY; Li, L; Liang, SR; Luo, M; Yang, EN, 2013) |
| "The BDL rats developed chronic liver failure and exhibited a decreased discrimination index for short term memory (STM) when compared to the control group." | 1.39 | Impairment of short term memory in rats with hepatic encephalopathy due to bile duct ligation. ( Escobar, TD; Forgiarini, LF; Hammes, TO; Keiding, S; Leke, R; Meyer, FS; Oliveira, DL; Schousboe, A; Silveira, TR, 2013) |
| "We analyzed the presence of mild cognitive impairment (CI) by using the PHES battery of psychometric tests and measured the levels of ammonia and of the inflammatory cytokines IL-6 and IL-18 in blood of patients with different types of liver or dermatological diseases resulting in different grades of hyperammonemia and/or inflammation." | 1.38 | Contribution of hyperammonemia and inflammatory factors to cognitive impairment in minimal hepatic encephalopathy. ( Cassinello, N; Civera, M; Felipo, V; Garcia-Torres, ML; Jordá, E; Martinez-Valls, J; Molina, I; Montesinos, E; Montoliu, C; Olmo, JA; Ortega, J; Serra, MA; Urios, A; Wassel, A, 2012) |
| "Hyperammonemia was significantly related to patient variables that had a poor outcome (R=0." | 1.38 | Prognostic value of venous blood ammonia in patients with out-of-hospital cardiac arrest. ( Kasai, A; Kikushima, K; Mastsuzaki, M; Matsuzaki, M; Nagao, K; Soga, T; Tachibana, E; Watanabe, K; Yagi, T, 2012) |
| "Brain edema is an important complication of acute hepatic encephalopathy (AHE), and astrocyte swelling is largely responsible for its development." | 1.38 | Role of cerebral endothelial cells in the astrocyte swelling and brain edema associated with acute hepatic encephalopathy. ( Jayakumar, AR; Norenberg, MD; Ospel, J; Tong, XY, 2012) |
| "Chronic hepatic encephalopathy is a characteristically reversible neuropsychiatric disorder that occurs mainly in patients with liver cirrhosis." | 1.38 | Regional reduction in gray and white matter volume in brains of cirrhotic patients: voxel-based analysis of MRI. ( Adachi, Y; Fujita, N; Gabazza, EC; Iwasa, M; Kobayashi, Y; Kuroda, M; Matsuda, H; Mifuji-Moroka, R; Moroka, H; Takei, Y, 2012) |
| "Minimal hepatic encephalopathy (MHE) is a neuro-cognitive dysfunction characterized by impairment in attention, vigilance and integrative functions, while the sensorimotor function was often unaffected." | 1.38 | Selective impairments of resting-state networks in minimal hepatic encephalopathy. ( Chen, H; Fan, X; Jiao, Q; Liao, W; Liu, Y; Lu, G; Ni, L; Qi, R; Wu, S; Wu, X; Xu, Q; Zhang, LJ; Zhang, Z; Zhong, J; Zhong, Y, 2012) |
| "Although the Psychometric Hepatic Encephalopathy Score (PHES) for the diagnosis of minimal hepatic encephalopathy (MHE) has been validated in several countries, further validation is required for its use in different populations." | 1.38 | Psychometric hepatic encephalopathy score for the detection of minimal hepatic encephalopathy in Korean patients with liver cirrhosis. ( An, H; Jung, JY; Keum, B; Kim, CD; Kim, CH; Kim, JD; Lee, HS; Ryu, HS; Seo, YS; Um, SH; Yim, HJ; Yim, SY, 2012) |
| "Hepatic encephalopathy is a neuropsychiatric disorder of complex pathogenesis caused by acute or chronic liver failure." | 1.37 | Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice. ( Avraham, Y; Berry, E; Grigoriadis, N; Ilan, Y; Magen, I; Mechoulam, R; Poutahidis, T; Vorobiev, L, 2011) |
| "The diagnosis of hepatic encephalopathy (HE) relies on clinical, neurophysiological, psychometric and laboratory variables." | 1.37 | Different biochemical correlates for different neuropsychiatric abnormalities in patients with cirrhosis. ( Amodio, P; Angeli, P; Biancardi, A; Carlà, V; Carraro, P; Gatta, A; Mannaioni, G; Montagnese, S; Moroni, F; Schiff, S; Tono, N, 2011) |
| "However, HE in patients with liver cirrhosis is not associated with an up-regulation of inflammatory cytokines in cerebral cortex, despite microglia activation." | 1.37 | Microglia activation in hepatic encephalopathy in rats and humans. ( Bidmon, HJ; Görg, B; Häussinger, D; Keitel, V; Schrör, K; Zemtsova, I, 2011) |
| "Minimal hepatic encephalopathy (MHE) is intermittently present in up to 2/3 of patients with chronic liver disease." | 1.37 | Critical flicker frequency and continuous reaction times for the diagnosis of minimal hepatic encephalopathy: a comparative study of 154 patients with liver disease. ( Jepsen, P; Lauridsen, MM; Vilstrup, H, 2011) |
| "Acute liver failure was surgically induced in swine by complete hepatectomy (n = 8)." | 1.37 | Neuromonitoring in a porcine model of acute hepatic failure. ( Frühauf, NR; Grabellus, F; Kaiser, GM; Laube, T; Radunz, S; Uerschels, AK, 2011) |
| "Besides, SC-560 treatment improved hepatic encephalopathy and decrease plasma levels of PGF(1α), but did not change TNF-α levels." | 1.37 | Selective cyclooxygenase inhibition improves hepatic encephalopathy in fulminant hepatic failure of rat. ( Chan, CY; Chang, CC; Chuang, CL; Huang, HC; Lee, FY; Lee, SD; Lin, HC; Nong, JY; Wang, SS, 2011) |
| "In addition, the psychometric hepatic encephalopathy score (PHES), continues reaction time, and biochemical profile were assessed." | 1.37 | Spectral and dynamic electroencephalogram abnormalities are correlated to psychometric test performance in hepatic encephalopathy. ( Blauenfeldt, RA; Drewes, A; Graversen, C; Hansen, JB; Hansen, TM; Olesen, SS; Steimle, K, 2011) |
| "A young woman with fulminant hepatic failure and coma received monitoring of transcerebral ammonia uptake before and after orthotopic liver transplantation." | 1.37 | Liver transplantation rapidly stops cerebral ammonia uptake in fulminant hepatic failure. ( Bellomo, R; Farley, KJ; Glassford, NJ; Warrillow, S, 2011) |
| "156 patients with cirrhosis (74 with hepatic encephalopathy and 82 without) were enrolled, and underwent clinical examination and blood testing." | 1.37 | Partial pressure of NH₃ in cirrhotic patients with and without hepatic encephalopathy. ( Gao, B; He, Y; Li, G; Luo, T; Song, H; Xu, J, 2011) |
| "The aetiology of minimal hepatic encephalopathy (mHE) remains unclear." | 1.37 | Absence of neuropsychological impairment in hyperammonaemia in healthy young adults; possible synergism in development of hepatic encephalopathy (HE) symptoms? ( Castle, PC; Smeeton, NJ; Watt, PW; Wilkinson, DJ, 2011) |
| "The pathophysiology of cerebral edema in ALF is incompletely understood." | 1.37 | Ammonia-induced brain swelling and neurotoxicity in an organotypic slice model. ( Back, A; Bai, T; Brorson, JR; Chiranand, P; Frank, JI; Goldenberg, FD; Tupper, KY, 2011) |
| "Hepatic encephalopathy is liver-kidney-intestine-brain syndrome." | 1.36 | [Analysis of the relationship between hepatorenal syndrome and plasma ammonia]. ( He, Y; Li, GX; Xia, Y, 2010) |
| "There is evidence to suggest that, in acute liver failure (ALF), brain ammonia and proinflammatory cytokines may act synergistically to cause brain edema and its complications (intracranial hypertension, brain herniation)." | 1.36 | Ammonia and proinflammatory cytokines modify expression of genes coding for astrocytic proteins implicated in brain edema in acute liver failure. ( Butterworth, RF; Chastre, A; Desjardins, P; Jiang, W, 2010) |
| "In acute hepatic encephalopathy, MR imaging abnormalities have been described in the PVWM, thalami, and corticospinal tracts." | 1.36 | Acute hepatic encephalopathy: diffusion-weighted and fluid-attenuated inversion recovery findings, and correlation with plasma ammonia level and clinical outcome. ( Brace, JR; Lohman, BD; McKinney, AM; Sarikaya, B; Singewald, T; Spanbauer, J; Uhlmann, E, 2010) |
| "To develop a reliable surgical model of acute hepatic failure and hyperammonemia in rats that avoids porto-systemic shunt and bile duct ligation, applicable to hepatic encephalopathy research." | 1.36 | A new experimental model for acute hepatic failure in rats. ( Bellodi-Privato, M; D'Albuquerque, LA; Kubrusly, MS; Leite, KR; Machado, MC; Molan, NT; Teixeira, AR, 2010) |
| "Minimal hepatic encephalopathy (MHE) has recently been reported in patients with extrahepatic portal venous obstruction (EHPVO)." | 1.36 | Cerebral oedema in minimal hepatic encephalopathy due to extrahepatic portal venous obstruction. ( Goel, A; Gupta, R; Pandey, CM; Rathore, R; Saraswat, V; Srivastava, A; Thomas, MA; Yadav, S, 2010) |
| "Hepatic encephalopathy was confirmed with low critical flicker test (CFF), and high blood ammonia level." | 1.36 | Normal protein diet and L-ornithine-L-aspartate for hepatic encephalopathy. ( Ndraha, S; Simadibrata, M, 2010) |
| "Cerebral edema is present in patients with MHE." | 1.36 | Effect of surgical portosystemic shunt on prevalence of minimal hepatic encephalopathy in children with extrahepatic portal venous obstruction: assessment by magnetic resonance imaging and psychometry. ( Gupta, RK; Lal, R; Saraswat, VA; Srivastava, A; Thomas, MA; Yachha, SK; Yadav, SK, 2010) |
| "Management of hepatic encephalopathy includes the eviction of the precipitating factor and prevention of recurrence." | 1.36 | [Hepatic encephalopathy in patients with cirrhosis: new aspects and practical recommendations]. ( Ditisheim, S; Spahr, L, 2010) |
| "Hyperammonemia is a main contributor to brain herniation and mortality in acute liver failure (ALF)." | 1.35 | Acute liver failure-induced death of rats is delayed or prevented by blocking NMDA receptors in brain. ( Agusti, A; Boix, J; Cauli, O; Felipo, V; Piedrafita, B; Rodrigo, R, 2008) |
| "Minimal hepatic encephalopathy (MHE) in patients with liver cirrhosis may have prognostic significance with regard to the development of clinical hepatic encephalopathy (HE) and deterioration in patient quality of life." | 1.35 | Neuropsychological impairment in severe acute viral hepatitis is due to minimal hepatic encephalopathy. ( Kumar, M; Sarin, SK; Sharma, BC; Sharma, P; Tyagi, P, 2009) |
| "In patients with hepatic encephalopathy (HE) the blood concentration of ammonia is usually highly elevated." | 1.35 | Backflux of ammonia from brain to blood in human subjects with and without hepatic encephalopathy. ( Keiding, S; Munk, OL; Sørensen, M, 2009) |
| "Hepatic encephalopathy is a severe neuropathological condition arising secondary to liver failure." | 1.35 | Metabolic fate of isoleucine in a rat model of hepatic encephalopathy and in cultured neural cells exposed to ammonia. ( Bak, LK; Iversen, P; Keiding, S; Ott, P; Schousboe, A; Sørensen, M; Vilstrup, H; Waagepetersen, HS, 2009) |
| "Ataxia has been suggested in the literature to be a symptom of hepatic encephalopathy (HE), but so far has not been objectively quantified." | 1.35 | Postural control in patients with liver cirrhosis: a posturographic study. ( Fialka-Moser, V; Gangl, A; Mittermaier, C; Peck-Radosavljevic, M; Schmid, M; Voller, B, 2009) |
| "An 86-year-old man with senile dementia was admitted due to disturbance of consciousness." | 1.35 | Congenital portal systemic encephalopathy misdiagnosed as senile dementia. ( Ichinose, M; Kawashima, A; Kondo, M; Miyata, K; Muroki, T; Nakao, R; Nakao, T; Nasu, T; Tamai, H; Uno, A, 2009) |
| "However, the efficacy of CsA to protect cytotoxic brain edema in ALF is problematic because it poorly crosses the blood-brain barrier, which is relatively intact in ALF." | 1.35 | Inhibitors of the mitochondrial permeability transition reduce ammonia-induced cell swelling in cultured astrocytes. ( Norenberg, MD; Rama Rao, KV; Reddy, PV, 2009) |
| "In 87 patients with acute liver failure admitted to the intensive care unit, we simultaneously evaluated arterial ammonia, pNH(3), clinical grade of hepatic encephalopathy, the sequential organ failure assessment score (SOFA score), and evidence of intracranial hypertension." | 1.35 | Severity of organ failure is an independent predictor of intracranial hypertension in acute liver failure. ( Ferenci, P; Funk, GC; Holzinger, U; Kaider, A; Kitzberger, R; Kramer, L; Madl, C; Miehsler, W, 2009) |
| "Minimal hepatic encephalopathy (MHE) impairs health-related quality of life and predicts overt hepatic encephalopathy (HE) in cirrhotic patients." | 1.35 | Predictors of nonresponse to lactulose for minimal hepatic encephalopathy in patients with cirrhosis. ( Sarin, SK; Sharma, BC; Sharma, P, 2009) |
| "One day after admission, she developed hepatic encephalopathy with ammonia concentrations in plasma >100 micromol/l." | 1.35 | Successful treatment of hepatic encephalopathy in a patient with acute lymphoblastic leukemia. ( Dada, R; Galm, O; Gassler, N; Jost, E; Osieka, R; Wilop, S, 2009) |
| "Minimal hepatic encephalopathy (MHE) is associated with poorer quality of life and increased work disability." | 1.34 | Critical flicker frequency: diagnostic tool for minimal hepatic encephalopathy. ( Puri, V; Sarin, SK; Sharma, BC; Sharma, P, 2007) |
| "Hepatic encephalopathy is considered to be mainly caused by increased ammonia metabolism of the brain." | 1.34 | Correlations between magnetic resonance spectroscopy alterations and cerebral ammonia and glucose metabolism in cirrhotic patients with and without hepatic encephalopathy. ( Ahl, B; Burchert, W; Fischer-Wasels, D; Hecker, H; Köstler, H; van den Hoff, J; Weissenborn, K, 2007) |
| "Studies on animal models of hepatic encephalopathy (HE) suggest that poor nutritional status may facilitate the development of HE." | 1.34 | Malnutrition and diabetes mellitus are related to hepatic encephalopathy in patients with liver cirrhosis. ( Bengtsson, M; Björnsson, E; Henfridsson, P; Hugosson, I; Jalan, R; Kalaitzakis, E; Olsson, R, 2007) |
| "Hepatic encephalopathy is a syndrome of potential reversible neurological symptoms." | 1.34 | [Confusion and abnormal liver enzyme levels: problems with diagnosing hepatic encephalopathy]. ( Hendriks, ME; Portegies, P; van Westerloo, DJ, 2007) |
| "6 patients with liver cirrhosis were included in this pilot study." | 1.33 | [Detection of subclinical and overt hepatic encephalopathy and treatment control after L-ornithine-L-aspartate medication by magnetic resonance spectroscopy ((1)H-MRS)]. ( Gregor, M; Hass, HG; Hösl, F; Kaiser, S; Nägele, T; Seeger, U, 2005) |
| "Cirrhotic patients without overt hepatic encephalopathy may have cerebral function alterations called minimal hepatic encephalopathy (MHE)." | 1.33 | Neuropsychological and neurophysiological evaluation in cirrhotic patients with minimal hepatic encephalopathy undergoing liver transplantation. ( Amodio, P; Bassanello, M; Burra, P; Canova, D; D'Aloiso, MC; Del Piccolo, F; Fagiuoli, S; Masier, A; Senzolo, M; Zanus, G, 2005) |
| "Myo-inositol levels were strongly decreased already at 3h after treatment with NH4Cl; other intracellular osmolytes, such as hypotaurine and choline-containing compounds were also decreased, along with a concomitant increase of both the total concentration and the amount of newly synthesized glutamine, alanine, and glutathione." | 1.33 | Ammonia toxicity under hyponatremic conditions in astrocytes: de novo synthesis of amino acids for the osmoregulatory response. ( Leibfritz, D; Zwingmann, C, 2005) |
| "Because hyperammonemia is thought to contribute to the pathogenesis of hepatic encephalopathy, we examined the effects of ammonia on ATP levels, neuronal morphology, and synaptic function in rat hippocampal slices." | 1.33 | Ammonia-mediated LTP inhibition: effects of NMDA receptor antagonists and L-carnitine. ( Funatsu, M; Izumi, M; Izumi, Y; Matsukawa, M; Zorumski, CF, 2005) |
| "Episodic hepatic encephalopathy has been described in patients with portal vein thrombosis, but it is not known if these patients develop minimal hepatic encephalopathy." | 1.33 | Noncirrhotic portal vein thrombosis exhibits neuropsychological and MR changes consistent with minimal hepatic encephalopathy. ( Alonso, J; Bosch, J; Córdoba, J; García-Pagán, JC; Mínguez, B; Rovira, A; Turnes, J, 2006) |
| "The status epilepticus was resolved after antiepileptic therapy (phenytoin sodium) and treatment for hepatic encephalopathy (Branched chain amino acids)." | 1.33 | Hepatic encephalopathy with status epileptics: a case report. ( Hamagami, H; Ichinose, M; Kida, Y; Tanaka, H; Tsuji, T; Ueda, H, 2006) |
| "The cause of liver failure included acute liver failure (n = 2), acute on chronic liver failure (n = 12), posthepatectomy liver failure (n = 4), and posttransplantation allograft failure (n = 4)." | 1.33 | Molecular adsorbent recirculating system treatment for patients with liver failure: the Hong Kong experience. ( Chan, LM; Chiu, A; Fan, ST, 2006) |
| "She had a 4-month history of repeated hepatic encephalopathy which persisted after treatment with oral medicine." | 1.33 | Surgical shunt closure via the lumen of an intrahepatic portal aneurysm. ( Ariizumi, S; Katagiri, S; Katsuragawa, H; Kotera, Y; Takasaki, K; Yamamoto, M; Yoshitoshi, K, 2006) |
| "Subclinical hepatic encephalopathy (SHE) were detected 55 in 47." | 1.33 | [The effects of Helicobacter pylori infection on hyperammonaemia and hepatic encephalopathy in cirrhotic patients]. ( Cai, JT; Chen, T; Lü, B; Si, JM; Wang, LJ, 2006) |
| "The correlation with the severity of hepatic encephalopathy was similar for venous (r=0." | 1.32 | Role of determination of partial pressure of ammonia in cirrhotic patients with and without hepatic encephalopathy. ( Attili, AF; Efrati, C; Masini, A; Merli, M; Nicolao, F; Riggio, O, 2003) |
| "Its role in acute hepatic failure (AHF) is controversial." | 1.32 | The effects of early and late administration of inhibitors of inducible nitric oxide synthase in a thioacetamide-induced model of acute hepatic failure in the rat. ( Hodgson, HJ; Rahman, TM, 2003) |
| "Hyperammonemia was induced by oral administration of an amino-acid (aa) solution mimicking hemoglobin composition." | 1.32 | Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis. ( Davies, NA; Jalan, R; Shawcross, DL; Williams, R, 2004) |
| "This system improves hepatic encephalopathy, renal dysfunction and some clinical parameters in acute liver failure, but there is no clear decrease in mortality." | 1.32 | [Albumin dialysis MARS (Molecular Adsorbent Recirculating System) as a bridge for liver transplantation in acute liver failure. Report of three cases]. ( Boltansky, A; Contreras, J; Cortés, C; Cotera, A; Díaz, JC; Guerrero, J; Oksenberg, D; Pacheco, A; Poniachik, J; Rojas, J; Sanhueza, ME; Segovia, E; Valera, JM, 2004) |
| "She was diagnosed as Sheehan's syndrome." | 1.31 | [A case of portal-systemic encephalopathy associated with Sheehan's syndrome]. ( Hashiguchi, H; Hashimoto, T; Mera, T; Tsuji, S, 2000) |
| "Patients with fulminant hepatic failure (FHF) often die awaiting liver transplantation." | 1.31 | Extracorporeal liver perfusion using human and pig livers for acute liver failure. ( Collier, DS; Dixon, RS; Fox, IJ; Fristoe, LW; Hammel, JM; Horslen, SP; Kangas, JA; Langnas, AN; Prentice, ED; Shaw, BW; Sudan, DL, 2000) |
| "To mimic episodic hepatic encephalopathy after gastrointestinal bleeding under controlled conditions, cirrhotic patients were challenged with an amino acid mixture of comparable composition to haemoglobin." | 1.31 | Amino acid challenge in patients with cirrhosis: a model for the assessment of treatments for hepatic encephalopathy. ( Al Mardini, H; Douglass, A; Record, C, 2001) |
| "A large portal-systemic shunt including gastric varices also causes severe encephalopathy in some cirrhotic patients." | 1.31 | Therapeutic effect of balloon-occluded retrograde transvenous obliteration on portal-systemic encephalopathy in patients with liver cirrhosis. ( Kato, T; Moriwaki, H; Nishigaki, Y; Sugihara, J; Tomita, E; Uematsu, T, 2001) |
| "Hepatic encephalopathy is a syndrome characterized by increased blood ammonia level and is one of the major complications of cirrhosis." | 1.31 | The protective effect of HD-03 in CCl4-induced hepatic encephalopathy in rats. ( Anturlikar, SD; Gopumadhavan, S; Mitra, SK; Seshadri, SJ; Venkataranganna, MV; Venkatesha Udupa, U, 2001) |
| "Non-alcoholic cirrhotics without overt hepatic encephalopathy (n=24) underwent (1)H-MR of the brain and neuropsychological tests." | 1.31 | The development of low-grade cerebral edema in cirrhosis is supported by the evolution of (1)H-magnetic resonance abnormalities after liver transplantation. ( Alonso, J; Castells, L; Córdoba, J; Esteban, R; Guardia, J; Jacas, C; Kulisewsky, J; Margarit, C; Rovira, A; Sanpedro, F; Vargas, V, 2001) |
| "Chronic hepatic encephalopathy (CHE) is a disabling complication of chronic liver failure and porto-systemic shunt." | 1.31 | [Chronic hepatic encephalopathy: the role of high serum manganese levels and its relation with basal ganglia lesions in nuclear magnetic resonance of the brain. Clinical case]. ( Caballero, L; Miranda, M, 2001) |
| "Acute hepatic failure was induced by end-to-side portocaval shunt and ligature of the whole porta hepatitis." | 1.31 | Reduced encephalopathy in pigs with ischemia-induced acute hepatic failure treated with a bioartificial liver containing alginate-entrapped hepatocytes. ( Bouix, A; Campion, JP; Clément, B; Desbois, J; Desille, M; Desjardins, JF; Frémond, B; Joly, A; Lebreton, Y; Mahler, S; Mallédant, Y; Sébille, V; Seguin, P, 2002) |
| "Extracorporeal liver perfusion in hepatic coma, used to eliminate toxic metabolites causing hepatic encephalopathy, is limited by the antibody (Ab) and complement-mediated hyperacute rejection of discordant xenografts." | 1.30 | Application of immunoapheresis for delaying hyperacute rejection during isolated xenogeneic pig liver perfusion. ( Hammer, C; Hoebel, G; Mueller-Derlich, J; Pascher, A; Poehlein, C; Stangl, M; Thiery, J, 1997) |
| "Latent or sub-clinical hepatic encephalopathy is a recognized complication of cirrhosis and is thought to represent one end of the spectrum of neuropsychiatric impairment, which occurrs as a result of portal-systemic shunting." | 1.30 | Oral glutamine challenge in cirrhotics pre- and post-liver transplantation: a psychometric and analyzed EEG study. ( Al-Mardini, H; Oppong, KN; Record, CO; Thick, M, 1997) |
| "pylori infection is associated with hepatic encephalopathy, especially in younger patients with decompensated liver disease." | 1.30 | Analysis of risk factors for chronic hepatic encephalopathy: the role of Helicobacter pylori infection. ( Dasani, BM; Lieber, CS; Sigal, SH, 1998) |
| "A prospective study of hepatic encephalopathy (HE) including neuropsychiatric and psychometric evaluation, electroencephalography, and determination of arterial ammonia levels was performed in 55 cirrhotic patients treated consecutively by transjugular intrahepatic portosystemic shunt (TIPS)." | 1.30 | Portosystemic hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in patients with cirrhosis: clinical, laboratory, psychometric, and electroencephalographic investigations. ( Figulla, HR; Hartmann, H; Münke, H; Nolte, W; Ramadori, G; Schindler, C; Unterberg, K; Werner, G; Wiltfang, J; Zumhasch, U, 1998) |
| "Hyponatremia was induced in rats with 1-desamino-8-D-arginine vasopressin (DDAVP) administered through an osmotic minipump for 1 week." | 1.30 | Chronic hyponatremia exacerbates ammonia-induced brain edema in rats after portacaval anastomosis. ( Blei, AT; Córdoba, J; Gottstein, J, 1998) |
| "Cerebral edema leading to cerebral herniation (CH) is a common cause of death in acute liver failure (ALF)." | 1.30 | Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration. ( Clemmesen, JO; Hansen, BA; Kondrup, J; Larsen, FS; Ott, P, 1999) |
| "Patients with severe acute alcoholic hepatitis develop multiple organ failure which is associated with production of inflammatory cytokines and a poor prognosis." | 1.30 | Temporary extracorporeal liver support for severe acute alcoholic hepatitis using the BioLogic-DT. ( Ellis, AJ; Hughes, RD; Langley, PG; Nicholl, D; O'Grady, JG; Wendon, JA; Williams, R, 1999) |
| "pylori) infection as a cause of hepatic encephalopathy is still debated." | 1.30 | Helicobacter pylori infection, plasma ammonia levels, and psychometric testing in cirrhotic patients. ( Attili, AF; Hassan, C; Meddi, P; Rinaldi, V; Winn, S; Zullo, A, 1999) |
| "We treated a 68-year-old male patient of hepatic encephalopathy with oral branched chain amino acids-enriched formula (Aminoleban EN) in addition to lactulose." | 1.30 | Long-term treatment of portosystemic encephalopathy with oral branched-chain amino acids--a case report. ( Fujishima, M; Fukuda, K; Ibayashi, S; Murai, K; Yao, H, 1999) |
| "HE in the presence of liver cirrhosis and/or portal-systemic shunting has been termed portal-systemic encephalopathy (PSE)." | 1.30 | Sleep disorders and portal-systemic encephalopathy following transjugular intrahepatic portosystemic stent shunt in patients with liver cirrhosis. Relation to plasma tryptophan. ( Bahn, E; Hajak, G; Nolte, W; Pilz, J; Ramadori, G; Rüther, E; von Heppe, J; Wiltfang, J, 1999) |
| "All animals were tested three times for seizure threshold, and were then decapitated and the brains removed for analysis of the amino acids." | 1.30 | Effects of ammonia on pentylenetetrazole-induced seizure threshold. ( Arikan, K; Coskun, T; Guvener, B; Oran, O, 1999) |
| "Lactitol and lactulose were compared in their effect on the concentrations of ammonia and amino acids in blood and cerebrospinal fluid (CSF) in Eck fistula dogs." | 1.29 | [The effect of lactitol (NS-4) on the concentrations of ammonia and amino acids in blood and cerebrospinal fluid in Eck fistula (portacaval-shunted) dogs]. ( Hirata, Y; Kimura, K; Ozaki, T; Sato, S; Suzuki, K; Watanabe, M; Yoshikuni, Y, 1995) |
| "Fever, psychomotor agitation, and arterial hypertension were more frequently observed preceding episodes of severe intracranial hypertension, and more than 50% of FHF patients with uncontrolled intracranial hypertension sustained severe brain injury in our series." | 1.29 | Factors associated with severe intracranial hypertension in candidates for emergency liver transplantation. ( Bell, R; Martin, P; Moritz, MJ; Muñoz, SJ; Northrup, B; Radomski, J, 1993) |
| "Two experimental hepatic comatose models with combined-type symptom were developed in rats." | 1.29 | [Effect of lactitol (NS-4) on the increase in blood and brain ammonia concentration and on coma in newly developed rat models of hepatic coma]. ( Hirata, Y; Kimura, K; Ozaki, T; Watanabe, M; Yoshikuni, Y, 1995) |
| "An unusual case of acute cerebral edema as part of the syndrome of portal systemic encephalopathy in an individual with established chronic liver disease is reported." | 1.29 | Acute cerebral edema as part of the syndrome of hepatic encephalopathy in an individual with chronic liver disease: a case report. ( Jabbour, N; Karavias, D; Van Thiel, DH, 1994) |
| "Experimental hepatic encephalopathy is thus not due to cerebral glutamate deficiency." | 1.29 | Extracellular brain glutamate during acute liver failure and during acute hyperammonemia simulating acute liver failure: an experimental study based on in vivo brain dialysis. ( Dalm, E; de Knegt, RJ; Fekkes, D; Hekking-Weyma, I; Schalm, SW; van der Rijt, CC, 1994) |
| "Acute liver failure was induced in 6 rabbits, acute hyperammonemia in 4 rabbits; 4 control rabbits received sodium-potassium-acetate." | 1.29 | 45CaCl2 autoradiography in brain from rabbits with encephalopathy from acute liver failure or acute hyperammonemia. ( de Knegt, RJ; Gramsbergen, JB; Schalm, SW, 1994) |
| "Acute liver failure was induced by two-stage liver devascularization, and acute hyperammonemia by prolonged ammonia infusion such that the plasma ammonia pattern found in acute liver failure was simulated." | 1.29 | Encephalopathy from acute liver failure and from acute hyperammonemia in the rabbit. A clinical and biochemical study. ( de Knegt, RJ; Groeneweg, M; Hekking-Weijma, I; Schalm, SW, 1994) |
| "Brain edema in hepatic encephalopathy has been associated with circulating ammonia that is metabolized to glutamine." | 1.29 | Brain ion and amino acid contents during edema development in hepatic encephalopathy. ( Hilgier, W; Olson, JE, 1994) |
| "Chronic hepatic encephalopathy is highly responsive to changes in diet, to antibiotic therapy and to ingestion of nondigestible disaccharides." | 1.29 | Gastrointestinal transit in cirrhotic patients: effect of hepatic encephalopathy and its treatment. ( Chien, MC; Fagiuoli, S; Gavaler, JS; Van Thiel, DH; Wright, HI, 1994) |
| "Acute liver failure was induced by a two-stage devascularization procedure." | 1.29 | Neuronal and glial marker proteins in encephalopathy associated with acute liver failure and acute hyperammonemia in the rabbit. ( de Knegt, RJ; Ding, M; Groeneweg, M; Haglid, KG; Hamberger, A; Schalm, SW; Wang, S, 1993) |
| "Hepatic encephalopathy was induced by a two-stage liver devascularization procedure and acute hyperammonemia by a prolonged ammonium-acetate infusion; rabbits receiving a sodium-potassium-acetate infusion served as controls." | 1.29 | Binding of the ligand [3H]MK-801 to the MK-801 binding site of the N-methyl-D-aspartate receptor during experimental encephalopathy from acute liver failure and from acute hyperammonemia in the rabbit. ( de Knegt, RJ; Kornhuber, J; Riederer, P; Rusche, K; Schalm, SW; Tan, J, 1993) |
| "In horses with hepatic necrosis, lipidosis, neoplasia and cirrhosis, progression of the disease was studied by serial measurements of total serum bile acid concentrations and of plasma glutamate dehydrogenase (GD) and gamma glutamyl transferase (gamma GT) and by liver biopsy." | 1.29 | Clinical and pathological studies in horses with hepatic disease. ( West, HJ, 1996) |
| "By contrast, rats with hepatic encephalopathy (HE) following administration of a hepatotoxin, thioacetamide, were characterized by CC edema and an increased Tau content in both BG and CC." | 1.29 | Relation of taurine transport and brain edema in rats with simple hyperammonemia or liver failure. ( Albrecht, J; Hilgier, W; Olson, JE, 1996) |
| "Hepatic encephalopathy (HE) is associated with elevated arterial ammonia levels." | 1.29 | Arterial ammonia with Blood Ammonia Checker II and with indophenol reaction to assess presence of hepatic encephalopathy. ( Gips, CH; Huizenga, JR; van Dam, GM, 1996) |
| "A 56 year-old-male liver cirrhosis patient was admitted because of hepatic encephalopathy with hyperammonemia." | 1.28 | [Positron emission tomography (PET) before and after treatment of hyperammonemia in a patient with decompensated liver cirrhosis]. ( Fujishima, M; Ichiya, Y; Ikeda, K; Kawatoko, T; Murai, K; Nomiyama, K; Sadoshima, S; Tsuji, H, 1991) |
| "Two experimental models of hepatic encephalopathy in the rat have been investigated in order to study the postulated relationship between plasma free fatty acids concentration (C6 - C22:0) and the degree of hepatic encephalopathy." | 1.28 | The relationship between plasma free fatty acids and experimentally induced hepatic encephalopathy in the rat. ( Bosman, DK; Chamuleau, RA; de Haan, JG; Jörning, GG; Maas, MA; Smit, JJ, 1991) |
| "A case of hepatic encephalopathy in a noncirrhotic child, who has undergone a previous mesocaval shunt for extrahepatic portal vein thrombosis, is presented." | 1.28 | Hepatic encephalopathy induced by small bowel obstruction in a noncirrhotic child with portal vein thrombosis. ( Gonzales, ER; Hastings, JC; Morton, D; Walker, LG, 1990) |
| "Rats with acute hepatic encephalopathy caused by liver ischemia also showed elevation of methanethiol mixed disulfide levels on challenge of methanethiol through the colon or inspired air, but to a significantly smaller extent than did the corresponding sham-operated rats." | 1.28 | Methanethiol metabolism and its role in the pathogenesis of hepatic encephalopathy in rats and dogs. ( Blom, HJ; Chamuleau, RA; Deutz, NE; Rothuizen, J; Tangerman, A, 1990) |
| "Galactosamine-induced hepatic coma is not associated with any functionally significant changes in the molecular components of the postsynaptic dopamine receptor." | 1.27 | [Pathogenesis of hepatic encephalopathy--studies in the rabbit model of acute liver failure]. ( Ferenci, P; Jones, EA; Pappas, SC; Schafer, DF, 1984) |
| " When various smaller dosage combinations of NH+4, methanethiol, and octanoic acid were injected simultaneously, coma occurred at lower brain and blood concentrations of ammonia and methanethiol." | 1.27 | Brain methanethiol and ammonia concentrations in experimental hepatic coma and coma induced by injections of various combinations of these substances. ( Doizaki, WM; Lyftogt, C; Zieve, L, 1984) |
| "Sex and etiology of liver cirrhosis did not affect the test results." | 1.27 | Quantitative psychometric testing and subclinical hepatic encephalopathy--comparative study between encephalopathic and non-encephalopathic patients with liver cirrhosis. ( Shiota, T, 1984) |
| "The effects of potentials toxins of hepatic coma on the blood-brain barrier (BBB) permeability of the rat have been examined using the Oldendorf technique." | 1.27 | Potential toxins of acute liver failure and their effects on blood-brain barrier permeability. ( Canalese, J; Ede, RJ; Wardle, EN; Williams, R; Zaki, AE, 1983) |
| "Hepatic encephalopathy is a neurometabolic syndrome caused by altered hepatic blood flow patterns and/or hepatic disease." | 1.27 | Hepatic encephalopathy. ( Tams, TR, 1985) |
| "The pathogenesis of hepatic encephalopathy associated with portal-systemic shunting is unknown, but theories purporting major roles for ammonia, AAAs, false neurotransmitters, and GABA have been advanced." | 1.27 | Portal-systemic encephalopathy and hepatic coma. ( Jensen, DM, 1986) |
| "Accompanying the hepatic encephalopathy were hematemesis, abdominal dropsy, and hyperammonemia, conditions observed in hepatic coma patients." | 1.27 | Blood ammonia levels and hepatic encephalopathy induced by CCl4 in rats. ( Sugihara, N; Yamamoto, H, 1987) |
| "During the development of acute hepatic encephalopathy, induced by acute liver ischemia, changes in brain 31P NMR spectra and EEG spectra were studied over 8:45 h in eight rats." | 1.27 | In vivo 31P NMR spectroscopy of the rat cerebral cortex during acute hepatic encephalopathy. ( Bovée, WM; Chamuleau, RA; de Beer, R; de Graaf, AA; Deutz, NE, 1988) |
| "Therefore, in liver cirrhosis a quotient derived from decreased PT and increased serum creatinine has a good prognostic value." | 1.27 | The role of protein metabolism in 204 liver cirrhotics with and without hepatic encephalopathy. I. Clinical and general biochemical findings. ( Kalk, JF; Koussouris, P; Motschenbacher, MT; Müting, D; Rausche, A, 1986) |
| "CSF levels of GABA in five dogs with portosystemic encephalopathy (100 +/- 13 pmol/ml) were not significantly different from those in five control dogs (96 +/- 14 pmol/ml)." | 1.27 | Cerebrospinal fluid gamma-aminobutyric acid levels in dogs with chronic portosystemic encephalopathy. ( Farrell, GC; Maddison, JE; Stewart, P; Yau, D, 1986) |
| " Rifaximin proved to be active on both aerobic and anaerobic bacteria and is thus effective, even at the dosage used, in the treatment of HE." | 1.27 | A non-absorbable rifamycin for treatment of hepatic encephalopathy. ( Celle, G; De Leo, C; Eftimiadi, C; Rovida, S; Schito, GC; Sukkar, GS; Testa, R, 1985) |
| " One group, termed stuporous (AS), received only enough ammonium acetate to interfere with grooming and exploratory activity; this dosage was insufficient to completely block the righting response, which was absent in the AC group." | 1.27 | Disruption of the blood-brain barrier in hyperammonemic coma and the pharmacologic effects of dexamethasone and difluoromethyl ornithine. ( Chandler, MD; McCandless, DW; Sears, ES, 1985) |
| "A case of hepatic encephalopathy revealing congenital hepatic fibrosis in a 47-year-old woman is reported." | 1.27 | [Congenital hepatic fibrosis disclosed late by hepatic encephalopathy]. ( Amouretti, M; Béraud, C; Couzigou, P; Julien, J; Richard-Molard, B, 1985) |
| "During the precoma, glycogen and phosphocreatine were decreased." | 1.27 | Cerebral acetylcholine and energy metabolism changes in acute ammonia intoxication in the lower primate Tupaia glis. ( Looney, GA; McCandless, DW; Modak, AT; Stavinoha, WB, 1985) |
| "Acute hepatic coma in the pigs was induced by complete devascularization of the liver." | 1.27 | Successful treatment of hepatic coma by a new artificial liver device in the pig. ( Höhnke, C; Jung, V; Kachel, F; Lee, KS; Lie, TS, 1985) |
| "Clinical improvement of hepatic encephalopathy and of the underlying neurotransmitter (serotonin) and ammonia derangements by administration of L-valine suggest a possible role of this competitive amino acid on intermediary metabolism and ammonia detoxification." | 1.26 | Oral and parenteral nutrition with L-Valine: mode of action. ( Jellinger, K; Kleinberger, G; Riederer, P; Weiser, M, 1980) |
| "In 24 Patients therapy for hepatic encephalopathy was limited to infusion of the branched-chain enriched amino acid solution only, with wake-up in 66% of this group." | 1.26 | Infusion of branched-chain enriched amino acid solution in patients with hepatic encephalopathy. ( Atamian, S; Bradford, RR; Dienstag, J; Fischer, JE; Freund, H; Holroyde, J; Lehrich, J; Rosen, H; Slemmer, E; Yoshimura, N, 1982) |
| "Current theories on the pathogenesis of hepatic encephalopathy indicate that intestinal bacteria produce cerebral toxins, such as ammonia; colectomy has been proposed in the treatment of chronic portal systemic encephalopathy." | 1.26 | Effect of colectomy upon ammonemia and glutaminemia in rats with stricture of the portal vein. ( Frick, A; Imler, M; Schlienger, JL, 1981) |
| " In the two cases presented there was a severe outbreak of hepatotoxic encephalopathy despite the fact that the dosage of salicylates did not exceed that generally recommended for children with rheumatic diseases." | 1.26 | Toxic encephalopathy with hyperammonaemia during high-dose salicylate therapy. ( Korpela, P; Lang, H; Mäkelä, AL, 1980) |
| "It is proposed that hyperammonaemia in liver cirrhosis or after portacaval shunt contributes to plasma neutral aminoacid imbalance and to increased activity of the blood-brain neutral amino-acid transport system." | 1.26 | Hyperammonaemia, plasma aminoacid imbalance, and blood-brain aminoacid transport: a unified theory of portal-systemic encephalopathy. ( Fischer, JE; James, JH; Jeppsson, B; Ziparo, V, 1979) |
| "Current theories on the pathogenesis of hepatic coma indicate that intestinal bacteria produce cerebral toxins, such as ammonia, mercaptans, and short-chain fatty acids." | 1.26 | Hyperammonemic coma after hepatectomy in germ-free rats. ( Schalm, SW; van der Mey, T, 1979) |
| "Lysine was incorporated into forebrain proteins at a rate of 1." | 1.26 | Chronic inhibition of brain protein synthesis after portacaval shunting. A possible pathogenic mechanism in chronic hepatic encephalopathy in the rat. ( Conn, M; Lockwood, AH; Wasterlain, CG, 1978) |
| "Ten patients in stage IV hepatic encephalopathy who had not responded to conventional therapy for at least 48 hrs were treated with one or more 4 hr periods of hemoperfusion." | 1.26 | Biochemical correlates of reversal of hepatic coma coated with charcoal hemoperfusion. ( Cohan, SL; Gelfand, MC; Knepshield, JH; Schreiner, GE; Winchester, JF, 1978) |
| "Because hepatic encephalopathy is mainly produced by toxic intestinal protein metabolites no protein should be adminstered at the beginining of the disease." | 1.26 | [Therapy of hepatic insufficiency]. ( Müting, D, 1977) |
| "Dopa, shows that the signs of hepatic encephalopathy are not directly related to the reduction in energy metabolism and that this metabolic disorder does not depend on a blocking of the dopaminergic synopses." | 1.26 | [Hepatic encephalopathies; hemodynamic and metabolic study of the influence of ammonia and levodopa]. ( Baldy-Moulinier, M; Bories, P; Michel, H; Passouant, P, 1977) |
| "3." | 1.25 | Exchange transfusion in hepatic coma: factors affecting results, with long-term follow-up data. ( Darin, JC; Hussey, CV; Lewis, JD; Varma, RR, 1975) |
| "Patients with hepatic encephalopathy had significantly elevated levels which usually fell to zero following therapy." | 1.24 | THE METABOLISM OF THE VOLATILE AMINES: VII. THE CLINICAL SIGNIFICANCE OF TWO COMPONENTS OF THE BLOOD AMMONIA LEVEL. ( TOBE, BA, 1964) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 595 (43.12) | 18.7374 |
| 1990's | 192 (13.91) | 18.2507 |
| 2000's | 210 (15.22) | 29.6817 |
| 2010's | 280 (20.29) | 24.3611 |
| 2020's | 103 (7.46) | 2.80 |
| Authors | Studies |
|---|---|
| Gioia, S | 3 |
| Ridola, L | 4 |
| Cristofaro, L | 1 |
| Merli, M | 8 |
| Faccioli, J | 1 |
| Riggio, O | 9 |
| Nardelli, S | 3 |
| Li, Y | 8 |
| Ju, S | 4 |
| Li, X | 2 |
| Zhou, YL | 1 |
| Qiang, JW | 4 |
| Wang, X | 3 |
| Vilchez, RA | 1 |
| Brusilow, WSA | 1 |
| Jain, A | 2 |
| Sharma, BC | 15 |
| Mahajan, B | 2 |
| Srivastava, S | 8 |
| Kumar, A | 3 |
| Sachdeva, S | 5 |
| Sonika, U | 2 |
| Dalal, A | 2 |
| Ferah Okkay, I | 1 |
| Okkay, U | 1 |
| Gundogdu, OL | 1 |
| Bayram, C | 1 |
| Mendil, AS | 1 |
| Ertugrul, MS | 1 |
| Hacimuftuoglu, A | 1 |
| Tranah, TH | 6 |
| Shawcross, DL | 19 |
| Deutsch-Link, S | 2 |
| Moon, AM | 2 |
| Jiang, Y | 1 |
| Barritt, AS | 1 |
| Tapper, EB | 8 |
| Safadi, R | 1 |
| Rahimi, RS | 7 |
| Thabut, D | 9 |
| Bajaj, JS | 8 |
| Ram Bhamidimarri, K | 1 |
| Pyrsopoulos, N | 1 |
| Potthoff, A | 1 |
| Bukofzer, S | 1 |
| Wang, L | 5 |
| Jamil, K | 1 |
| Devarakonda, KR | 1 |
| Shafey, GM | 1 |
| Rashed, ER | 1 |
| Zaki, HF | 1 |
| Attia, AS | 1 |
| El-Ghazaly, MA | 1 |
| Yukawa-Muto, Y | 1 |
| Kamiya, T | 1 |
| Fujii, H | 1 |
| Mori, H | 1 |
| Toyoda, A | 1 |
| Sato, I | 1 |
| Konishi, Y | 1 |
| Hirayama, A | 1 |
| Hara, E | 1 |
| Fukuda, S | 1 |
| Kawada, N | 1 |
| Ohtani, N | 1 |
| Kroupina, K | 1 |
| Bémeur, C | 5 |
| Rose, CF | 15 |
| Sørensen, M | 12 |
| Walls, AB | 1 |
| Dam, G | 4 |
| Bak, LK | 7 |
| Andersen, JV | 1 |
| Ott, P | 14 |
| Vilstrup, H | 15 |
| Schousboe, A | 9 |
| Macedo de Oliveira, M | 1 |
| Monnet-Aimard, A | 1 |
| Bosoi, CR | 8 |
| Tremblay, M | 7 |
| Kovalic, AJ | 1 |
| Lee, TP | 1 |
| Da, BL | 1 |
| Huang, HC | 6 |
| Hsu, SJ | 3 |
| Chang, CC | 5 |
| Chuang, CL | 3 |
| Hou, MC | 2 |
| Lee, FY | 7 |
| Lu, J | 1 |
| Zhang, C | 1 |
| Yang, X | 3 |
| Qiang, J | 2 |
| Ballester, MP | 5 |
| Carbonell-Asins, JA | 5 |
| Ampuero, J | 6 |
| Alexandrino, G | 1 |
| Caracostea, A | 1 |
| Sánchez-Torrijos, Y | 1 |
| Thomsen, KL | 4 |
| Kerbert, AJC | 3 |
| Capilla-Lozano, M | 1 |
| Romero-Gómez, M | 12 |
| Escudero-García, D | 1 |
| Montoliu, C | 7 |
| Jalan, R | 29 |
| Fallahzadeh, MA | 1 |
| Abdelaziz, RR | 1 |
| Abdelrahman, RS | 1 |
| Abdelmageed, ME | 1 |
| Hayakawa, Y | 1 |
| Tamaki, N | 1 |
| Nakanishi, H | 1 |
| Kurosaki, M | 1 |
| Tanaka, Y | 1 |
| Inada, K | 1 |
| Ishido, S | 1 |
| Kirino, S | 1 |
| Yamashita, K | 1 |
| Nobusawa, T | 1 |
| Matsumoto, H | 2 |
| Kakegawa, T | 1 |
| Higuchi, M | 1 |
| Takaura, K | 1 |
| Tanaka, S | 1 |
| Maeyashiki, C | 1 |
| Kaneko, S | 1 |
| Yasui, Y | 1 |
| Takahashi, Y | 1 |
| Tsuchiya, K | 1 |
| Okamoto, R | 1 |
| Izumi, N | 1 |
| Mukund, A | 1 |
| Choudhury, SP | 1 |
| Tripathy, TP | 1 |
| Ananthashayana, VH | 1 |
| Jagdish, RK | 2 |
| Arora, V | 1 |
| Singh, SP | 1 |
| Mishra, AK | 1 |
| Sarin, SK | 10 |
| Mallet, M | 3 |
| Desplats, V | 1 |
| Bouzbib, C | 1 |
| Sultanik, P | 2 |
| Alioua, I | 1 |
| Rudler, M | 4 |
| Weiss, N | 5 |
| Roy, S | 1 |
| Chakrabarti, M | 1 |
| Dasgupta, H | 1 |
| Mahale, A | 1 |
| Tripathi, S | 1 |
| Sharma, V | 1 |
| Banerjee, M | 1 |
| Kulkarni, OP | 1 |
| Lopes, FF | 1 |
| Sitta, A | 1 |
| de Moura Coelho, D | 1 |
| Ribas, GS | 1 |
| Faverzani, JL | 1 |
| Dos Reis, BG | 1 |
| Wajner, M | 1 |
| Vargas, CR | 1 |
| Yokoyama, K | 1 |
| Fukuda, H | 1 |
| Yamauchi, R | 1 |
| Higashi, M | 1 |
| Miyayama, T | 1 |
| Higashi, T | 3 |
| Uchida, Y | 1 |
| Shibata, K | 1 |
| Tsuchiya, N | 1 |
| Fukunaga, A | 1 |
| Umeda, K | 1 |
| Takata, K | 1 |
| Tanaka, T | 2 |
| Shakado, S | 1 |
| Sakisaka, S | 1 |
| Hirai, F | 1 |
| Qi, W | 1 |
| Ge, Y | 1 |
| Li, Z | 3 |
| Wang, N | 1 |
| He, H | 1 |
| Luo, X | 1 |
| Ma, W | 1 |
| Chen, L | 1 |
| Liu, Y | 3 |
| Zhang, T | 1 |
| Claeys, W | 1 |
| Van Hoecke, L | 1 |
| Geerts, A | 1 |
| Van Vlierberghe, H | 1 |
| Lefere, S | 1 |
| Van Imschoot, G | 1 |
| Van Wonterghem, E | 1 |
| Ghesquière, B | 1 |
| Vandenbroucke, RE | 1 |
| Van Steenkiste, C | 1 |
| Mikkelsen, ACD | 1 |
| Aagaard, NK | 2 |
| de Wit, K | 3 |
| Beuers, U | 3 |
| Mukha, A | 3 |
| Stigter, ECA | 3 |
| Gulersonmez, MC | 3 |
| Ramos Pittol, JM | 3 |
| Middendorp, S | 3 |
| Takkenberg, RB | 3 |
| van Mil, SWC | 3 |
| Huang, L | 1 |
| Yu, Q | 1 |
| Peng, H | 1 |
| Zhen, Z | 1 |
| Wang, J | 3 |
| Zhang, Y | 5 |
| Xiang, Z | 1 |
| Zöllner, HJ | 1 |
| Thiel, TA | 1 |
| Füllenbach, ND | 1 |
| Jördens, MS | 1 |
| Ahn, S | 1 |
| Wilms, LM | 1 |
| Ljimani, A | 1 |
| Häussinger, D | 15 |
| Butz, M | 3 |
| Wittsack, HJ | 3 |
| Schnitzler, A | 3 |
| Oeltzschner, G | 3 |
| Murakami, T | 1 |
| Shimizu, H | 1 |
| Yogi, N | 1 |
| Hosokawa, I | 1 |
| Nojima, H | 1 |
| Ohno, T | 1 |
| Hike, S | 1 |
| Usui, A | 1 |
| Kosugi, C | 1 |
| Shuto, K | 1 |
| Yamazaki, M | 1 |
| Koda, K | 1 |
| Lu, K | 1 |
| Hannah, N | 1 |
| Vasic, D | 1 |
| Kansal, A | 1 |
| Al-Ani, A | 1 |
| Hebbard, G | 1 |
| Sood, S | 1 |
| Gairing, SJ | 1 |
| Mangini, C | 1 |
| Zarantonello, L | 2 |
| Nielsen, EJ | 1 |
| Danneberg, S | 1 |
| Gabriel, M | 1 |
| Ehrenbauer, AF | 1 |
| Bloom, PP | 2 |
| Ripoll, C | 3 |
| Galle, PR | 1 |
| Labenz, J | 1 |
| Zipprich, A | 3 |
| Lok, AS | 1 |
| Weissenborn, K | 7 |
| Marquardt, JU | 1 |
| Lauridsen, MM | 3 |
| Montagnese, S | 5 |
| Labenz, C | 1 |
| Cheon, SY | 1 |
| Kim, MY | 1 |
| Kim, J | 2 |
| Kim, EJ | 1 |
| Kam, EH | 1 |
| Cho, I | 1 |
| Koo, BN | 1 |
| Kim, SY | 1 |
| Eriksen, PL | 1 |
| Djernes, L | 1 |
| Nakadate, K | 1 |
| Sono, C | 1 |
| Mita, H | 1 |
| Itakura, Y | 1 |
| Kawakami, K | 1 |
| Ramakrishna, K | 1 |
| Sinku, S | 1 |
| Majumdar, S | 1 |
| Singh, N | 1 |
| Gajendra, TA | 1 |
| Rani, A | 1 |
| Krishnamurthy, S | 1 |
| Shi, J | 1 |
| Li, F | 1 |
| Amodio, P | 4 |
| Essam, RM | 1 |
| Saadawy, MA | 1 |
| Gamal, M | 1 |
| Abdelsalam, RM | 1 |
| El-Sahar, AE | 1 |
| Greinert, R | 2 |
| Reuken, P | 1 |
| Reichert, MC | 1 |
| Weber, SN | 1 |
| Hupfer, Y | 1 |
| Staltner, R | 1 |
| Meier Clinien, M | 1 |
| Lammert, F | 1 |
| Bruns, T | 1 |
| Ju, SG | 1 |
| Lee, JM | 1 |
| Shim, J | 1 |
| Balcar, L | 2 |
| Fiorillo, A | 1 |
| Escudero, MD | 1 |
| Mandorfer, M | 1 |
| Reiberger, T | 2 |
| Zhu, R | 1 |
| Liu, L | 2 |
| Zhang, G | 2 |
| Dong, J | 1 |
| Ren, Z | 1 |
| Maharshi, S | 2 |
| Sharma, A | 1 |
| Bara, S | 1 |
| Abdelmohcine, A | 1 |
| Amine, SE | 1 |
| Warda, K | 1 |
| Baz, SE | 1 |
| Khanouchi, M | 1 |
| El-Mansoury, B | 1 |
| Agnaou, M | 1 |
| Smimih, K | 1 |
| Zouhairi, N | 1 |
| Chatoui, H | 1 |
| Draoui, A | 1 |
| Saad, F | 1 |
| Ahmed, EM | 1 |
| Ferssiwi, A | 1 |
| Bitar, A | 1 |
| Jayakumar, AR | 11 |
| Fdil, N | 1 |
| Hiba, OE | 1 |
| Gao, J | 1 |
| Nie, R | 1 |
| Chang, H | 1 |
| Yang, W | 1 |
| Ren, Q | 1 |
| Liu, XF | 1 |
| Lu, JJ | 1 |
| Yang, XY | 1 |
| Liao, Y | 1 |
| Zhang, L | 4 |
| Wang, JT | 1 |
| Yue, ZD | 1 |
| Fan, ZH | 1 |
| Wu, YF | 1 |
| Dong, CB | 1 |
| Wang, XQ | 1 |
| Cui, T | 1 |
| Meng, MM | 1 |
| Bao, L | 1 |
| Chen, SB | 1 |
| Liu, FQ | 1 |
| Kosenko, EA | 1 |
| Alilova, GA | 1 |
| Tikhonova, LA | 1 |
| Benítez, C | 1 |
| Muñoz, A | 1 |
| Poniachik, J | 2 |
| Ramírez, F | 1 |
| Muñoz, C | 1 |
| Cermenati, T | 1 |
| Martínez, N | 1 |
| Díaz, P | 1 |
| Meneses, L | 1 |
| Chung, RT | 1 |
| Hassanein, TI | 1 |
| Padilla-Martinez, M | 1 |
| Kayali, Z | 1 |
| Rockey, DC | 6 |
| Sasso, R | 1 |
| Muthukumar, AR | 1 |
| Lee, WM | 1 |
| Denney, WS | 1 |
| Gavis, EA | 1 |
| Anderson, C | 1 |
| Blankstein, L | 1 |
| Brennan, AM | 1 |
| Puurunen, MK | 1 |
| Lawitz, E | 1 |
| Senzolo, M | 2 |
| Formentin, C | 1 |
| Orlando, C | 1 |
| Beltrame, R | 1 |
| Vuerich, A | 1 |
| Angeli, P | 2 |
| Burra, P | 2 |
| Yanny, B | 1 |
| Winters, A | 1 |
| Boutros, S | 1 |
| Saab, S | 2 |
| Montes-Cortes, DH | 2 |
| Olivares-Corichi, IM | 2 |
| Rosas-Barrientos, JV | 2 |
| Manuel-Apolinar, L | 1 |
| Martìnez-Godinez, MLA | 1 |
| Hernández-López, JC | 1 |
| Cruz-Dominguez, MDP | 1 |
| Lu, L | 2 |
| Wu, C | 1 |
| Lu, BJ | 1 |
| Xie, D | 1 |
| Wang, Z | 2 |
| Bahaji Azami, NL | 1 |
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| Gaglio, PJ | 1 |
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| Wu, G | 2 |
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| Tadokoro, T | 1 |
| Mimura, S | 1 |
| Nomura, T | 1 |
| Yoneyama, H | 1 |
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| Clément, MA | 1 |
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| Ruan, J | 1 |
| Li, D | 1 |
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| Han, Z | 1 |
| Qiu, W | 1 |
| Kabbani, AR | 1 |
| Tergast, TL | 1 |
| Manns, MP | 2 |
| Maasoumy, B | 1 |
| Manzhalii, EG | 1 |
| Falalyeyeva, TM | 1 |
| Moyseyenko, VO | 1 |
| Weiskirchen, R | 1 |
| Stremmel, W | 1 |
| Madsen, M | 1 |
| Kimer, N | 1 |
| Bendtsen, F | 1 |
| Petersen, AM | 1 |
| Butterworth, RF | 36 |
| Marino, RT | 1 |
| Sidlak, AM | 1 |
| Duriseti, P | 1 |
| Mamtani, R | 1 |
| Madias, NE | 1 |
| Strom, JA | 1 |
| Solipuram, V | 1 |
| Baretti, M | 1 |
| Kim, AY | 1 |
| Chen, LX | 1 |
| Fahrner, JA | 1 |
| Gunay-Aygun, M | 1 |
| Peng, XP | 1 |
| Hardenbergh, D | 1 |
| Ferguson, A | 1 |
| Griffith, P | 1 |
| Brancati, M | 1 |
| Gopalakrishna, H | 1 |
| Kato, T | 3 |
| Shubert, C | 1 |
| Laheru, D | 1 |
| Yarchoan, M | 1 |
| Tan, SL | 1 |
| Du, J | 1 |
| Chen, Y | 2 |
| Jia, J | 1 |
| Feng, JG | 1 |
| Liu, KX | 1 |
| Zhou, J | 1 |
| Verma, N | 1 |
| Choudhury, A | 1 |
| Taneja, S | 1 |
| Duseja, A | 2 |
| Singh, V | 1 |
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| Devarbhavi, H | 1 |
| Shukla, A | 2 |
| Ning, Q | 1 |
| Hamid, SS | 1 |
| Butt, AS | 1 |
| Jafri, W | 1 |
| Tan, SS | 1 |
| Hu, J | 1 |
| Zhongping, D | 1 |
| Treeprasertsuk, S | 1 |
| Lee, GH | 1 |
| Ghazinyan, H | 1 |
| Lesmana, LA | 1 |
| Sood, A | 1 |
| Midha, V | 1 |
| Goyal, O | 1 |
| Kim, DJ | 1 |
| Eapen, CE | 1 |
| Goel, A | 2 |
| Tao, H | 1 |
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| Singh, A | 1 |
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| Prasad, VGM | 1 |
| Shresta, A | 1 |
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| Payawal, DA | 1 |
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| Hadjihambi, A | 3 |
| Arias, N | 1 |
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| Su, HH | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter, Randomized Phase 2B Study to Evaluate the Efficacy, Safety and Tolerability of OCR-002 (Ornithine Phenylacetate) in Hospitalized Patients With Cirrhosis and Associated Hyperammonemia With an Episode of Hepatic Encephalopathy (STOP-HE Study)[NCT01966419] | Phase 2 | 231 participants (Actual) | Interventional | 2014-01-07 | Completed | ||
| Influence of Shunt Occlusion on Organ Functions in Hyperammonemic Patients With Cirrhosis Having Porto-systemic Shunt. A Randomized Controlled Trial.[NCT03293459] | 40 participants (Actual) | Interventional | 2017-07-03 | Completed | |||
| The Importance of Bilirubin Molecular Species in Patients With Liver Cirrhosis Who Develop Hepatic Encephalopathy and Patients With Acute-on-chronic Liver Failure[NCT05566548] | 50 participants (Anticipated) | Observational | 2022-08-01 | Recruiting | |||
| Early Diagnosis and Timely Treatment of Cirrhotic Patients With Minimal Hepatic Encephalopathy (CHESS-NCRCID 2106)[NCT05140837] | 10,000 participants (Anticipated) | Observational | 2021-12-09 | Recruiting | |||
| Expanding the Therapeutic Landscape of Post-TIPS Hepatic Encephalopathy[NCT05346029] | 140 participants (Anticipated) | Interventional | 2022-01-01 | Recruiting | |||
| A Multicenter, Prospective, Randomized Controlled Study to Explore the Efficacy and Safety of Fecal Microbiota Transplantation With Different Bacterial Doses in the Treatment of Recurrent Hepatic Encephalopathy[NCT05669651] | 100 participants (Anticipated) | Interventional | 2022-12-01 | Active, not recruiting | |||
| Serum Endotoxins, Inflammatory Mediators and MR Spectroscopy Before and After Treatment in Minimal Hepatic Encephalopathy[NCT01446523] | 60 participants (Actual) | Interventional | 2011-10-31 | Completed | |||
| A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of HPN-100 for Maintaining Remission in Subjects With Cirrhosis and Episodic Hepatic Encephalopathy[NCT00999167] | Phase 2 | 189 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
| Effect of Polyethylene Glycol Versus Lactulose on Hepatic Encephalopathy in Patients With Liver Cirrhosis; a Randomized Clinical Trial (PEGHE Trial)[NCT04436601] | Phase 4 | 102 participants (Anticipated) | Interventional | 2020-03-09 | Recruiting | ||
| Plasma Free Amino Acids in Patients With Hepatic Encephalopathy and Its Impact on Disease Outcomes.[NCT03306498] | 100 participants (Anticipated) | Observational | 2017-12-15 | Not yet recruiting | |||
| Role of Magnetic Resonance Imaging in Detection of Minimal Hepatic Encephalopathy[NCT04131205] | 40 participants (Anticipated) | Observational | 2019-06-01 | Recruiting | |||
| Comparison of Critical Flicker Fusion vs. Automated Visual Fields in the Detection of Early Glaucoma[NCT01076114] | 58 participants (Actual) | Observational | 2010-02-28 | Completed | |||
| Efficacy of Intravenous 'L-ornithine L-aspartate' in Reversal of Overt Acute Hepatic Encephalopathy in Patients With Liver Cirrhosis: a Prospective, Randomized, Double-blind, Placebo Controlled Trial[NCT01722578] | Phase 4 | 200 participants (Actual) | Interventional | 2013-12-31 | Completed | ||
| Safety and Efficacy of Steroids in the Management of Fulminant Hepatic Failure Due to Hepatitis A Virus in the Pediatric Age Group[NCT02375867] | Phase 4 | 33 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Driving Skills Recovery Following Procedural Sedation for Gastrointestinal Endoscopy: A Prospective Cohort Study[NCT04350424] | 68 participants (Actual) | Observational | 2019-03-05 | Terminated (stopped due to Lack of resources and Covid-19) | |||
| Evaluation of the Therapeutic Effect of Rifaximin on Covert Hepatic Encephalopathy With Underlying Small Intestinal Bacterial Overgrowth and Gastrointestinal Dysmotility in Liver Cirrhosis Patients[NCT04244877] | Phase 3 | 0 participants (Actual) | Interventional | 2021-09-15 | Withdrawn (stopped due to Study was unable to recruit participants..) | ||
| Effect of Rifaximin on Driving Performance, Psychometric Test Performance and Quality of Life in Cirrhotic Patients With Minimal Hepatic Encephalopathy: Randomized, Double-blind, Placebo-controlled Trial.[NCT00533910] | 42 participants (Actual) | Interventional | 2007-10-31 | Completed | |||
| Intravenous Branched-chain Amino Acids for Overt Hepatic Encephalopathy in Patients With Acute on Chronic Liver Failure - A Multi-centric Double-blind Randomized Controlled Trial[NCT05700695] | Phase 1 | 246 participants (Anticipated) | Interventional | 2023-01-17 | Recruiting | ||
| Efficacy of Lactulose Plus Intravenous Branched Chain Amino Acids Versus Lactulose Alone in Patients of Acute on Chronic Liver Failure With Overt Hepatic Encephalopathy: A Prospective Randomized Clinical Trial[NCT04238416] | Phase 1 | 70 participants (Actual) | Interventional | 2019-11-01 | Completed | ||
| ORAL ACETYL-L-CARNITINE THERAPY REDUCES FATIGUE IN HEPATIC ENCEPHALOPATHY[NCT01223742] | 0 participants | Interventional | 2002-06-30 | Completed | |||
| Glutamine Challenge as Predictor of Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt (TIPS)[NCT02026609] | 3 participants (Actual) | Observational | 2013-05-31 | Terminated (stopped due to Lack of patient accrual) | |||
| Efficacy and Safety of the Albumin Dialysis MARS® Therapy in Patients With Fulminant and Subfulminant Hepatic Failure[NCT00224705] | Phase 3 | 110 participants (Actual) | Interventional | 2004-08-31 | Completed | ||
| Probiotics for the Prevention of Major Complications of Cirrhosis[NCT00312910] | 50 participants (Anticipated) | Interventional | 2005-04-30 | Completed | |||
| Probiotics in Patients With Primary Sclerosing Cholangitis and Inflammatory Bowel Disease- a Randomized Placebo-Controlled Cross-Over Trial[NCT00161148] | Phase 3 | 12 participants | Interventional | 2005-01-31 | Recruiting | ||
| [NCT00678613] | Phase 2/Phase 3 | 250 participants (Anticipated) | Interventional | 2007-07-31 | Recruiting | ||
| Brain Energy Metabolism in Patients With Acute Hepatic Encephalopathy Measured With PET[NCT00424957] | 18 participants (Anticipated) | Observational | 2006-11-30 | Completed | |||
| A Phase 2a Study to Evaluate the Safety and Tolerability of OCR-002 (Ornithine Phenylacetate) in the Treatment of Patients With Acute Liver Failure/Severe Acute Liver Injury[NCT01548690] | Phase 2 | 47 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure: A Double- Blind, Randomized, Placebo- Controlled Study[NCT00470314] | Phase 2 | 150 participants (Actual) | Interventional | 2005-01-31 | Active, not recruiting | ||
| Bispectral Index Monitoring of Propofol Anesthesia in Patients With Hydrocephalus. A Prospective Observational Study[NCT02575105] | 60 participants (Actual) | Observational | 2008-05-31 | Completed | |||
| Effect of Age on Propofol-Bispectral Index Response Relationship Among Different Age Groups From Vicenarians to Nonagenarians. A New Logistic Model Compared With Traditional Sigmoid Emax Model[NCT02585284] | 80 participants (Actual) | Observational | 2011-09-30 | Completed | |||
| Acetyl-L-Carnitine Reduces Depression and Improves Quality of Life in Patients With Minimal Hepatic Encephalopathy[NCT01223729] | 67 participants | Interventional | 2002-04-30 | Completed | |||
| The Use of Novel Therapies to Reconstitute Blood Cell Production and Promote Organ Performance Using Bone Marrow Failure as a Model: a Pilot, Phase I/II Study of the Amino Acid Leucine in the Treatment of Patients With Transfusion-Dependent Diamond Blackf[NCT01362595] | Phase 1/Phase 2 | 55 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| Hepatocyte Transplantation for Acute Decompensated Liver Failure[NCT01345565] | Phase 1 | 0 participants (Actual) | Interventional | 2011-03-31 | Withdrawn (stopped due to A funding mechanism is not identified at this time) | ||
| A Randomized, Double-Blind, Crossover Study of Sodium Phenylbutyrate and Low-Dose Arginine Compared to High-Dose Arginine Alone on Liver Function, Ureagenesis and Subsequent Nitric Oxide Production in Patients With Argininosuccinic Aciduria[NCT00345605] | Phase 2 | 12 participants (Actual) | Interventional | 2008-02-29 | Completed | ||
| The Effectiveness of L-ornithine-L-aspartate on Plasma Ammonia in Cirrhotic Patients After TIPS Procedure: a Prospective, Randomized, Controlled, Open-label Clinical Trial[NCT01440829] | Phase 2/Phase 3 | 40 participants (Actual) | Interventional | 2011-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"To support the primary endpoint of confirmed clinical response, the investigator rated participants on a 4-point staging scale, where higher scores are worse.~The stages are described as:~Stage 0/1 = Participant has no tremor of the hand when the wrist is extended (asterixis) and no confusion, even about where they are (disorientation) Stage 2 = Participant has tremor of the hand when the wrist is extended (asterixis) and is confused, not knowing where they are (disorientation) Stage 3 = Participant is tired, falling asleep, answers questions but is confused, and doesn't know where they are (Stupor, arousable but falls asleep, responsive to verbal stimuli, Obvious confusion, Gross disorientation) Stage 4 = Participant is unconscious (in a coma)" (NCT01966419)
Timeframe: Baseline to End of Study (through 3 hours post end-of-infusion)
| Intervention | percentage of participants (Number) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline : Stage 4 | Baseline : Stage 3 | Baseline : Stage 2 | Baseline : Stage 0/1 | Baseline : Missing | Day 1, 7 am : Stage 4 | Day 1, 7 am : Stage 3 | Day 1, 7 am : Stage 2 | Day 1, 7 am : Stage 0/1 | Day 1, 7 am : Missing | Day 1, 5 pm : Stage 4 | Day 1, 5 pm : Stage 3 | Day 1, 5 pm : Stage 2 | Day 1, 5 pm : Stage 0/1 | Day 1, 5 pm : Missing | Day 2, 7 am : Stage 4 | Day 2, 7 am : Stage 3 | Day 2, 7 am : Stage 2 | Day 2, 7 am : Stage 0/1 | Day 2, 7 am : Missing | Day 2, 5 pm : Stage 4 | Day 2, 5 pm : Stage 3 | Day 2, 5 pm : Stage 2 | Day 2, 5 pm : Stage 0/1 | Day 2, 5 pm : Missing | Day 3, 7 am : Stage 4 | Day 3, 7 am : Stage 3 | Day 3, 7 am : Stage 2 | Day 3, 7 am : Stage 0/1 | Day 3, 7 am : Missing | Day 3, 5 pm : Stage 4 | Day 3, 5 pm : Stage 3 | Day 3, 5 pm : Stage 2 | Day 3, 5 pm : Stage 0/1 | Day 3, 5 pm : Missing | Day 4, 7 am : Stage 4 | Day 4, 7 am : Stage 3 | Day 4, 7 am : Stage 2 | Day 4, 7 am : Stage 0/1 | Day 4, 7 am : Missing | Day 4, 5 pm : Stage 4 | Day 4, 5 pm : Stage 3 | Day 4, 5 pm : Stage 2 | Day 4, 5 pm : Stage 0/1 | Day 4, 5 pm : Missing | Day 5, 7 am : Stage 4 | Day 5, 7 am : Stage 3 | Day 5, 7 am : Stage 2 | Day 5, 7 am : Stage 0/1 | Day 5, 7 am : Missing | Day 5, 5 pm : Stage 4 | Day 5, 5 pm : Stage 3 | Day 5, 5 pm : Stage 2 | Day 5, 5 pm : Stage 0/1 | Day 5, 5 pm : Missing | Day 6, 7 am : Stage 4 | Day 6, 7 am : Stage 3 | Day 6, 7 am : Stage 2 | Day 6, 7 am : Stage 0/1 | Day 6, 7 am : Missing | Day 6, 5 pm : Stage 4 | Day 6, 5 pm : Stage 3 | Day 6, 5 pm : Stage 2 | Day 6, 5 pm : Stage 0/1 | Day 6, 5 pm : Missing | End of Study : Stage 4 | End of Study : Stage 3 | End of Study : Stage 2 | End of Study : Stage 0/1 | End of Study : Missing | |
| Ornithine Phenylacetate | 6 | 40 | 68 | 0 | 2 | 0 | 4 | 3 | 0 | 0 | 5 | 14 | 36 | 1 | 0 | 4 | 15 | 69 | 10 | 0 | 4 | 9 | 61 | 16 | 0 | 2 | 10 | 55 | 25 | 0 | 3 | 9 | 45 | 27 | 0 | 0 | 9 | 40 | 30 | 0 | 0 | 7 | 34 | 28 | 0 | 0 | 7 | 28 | 32 | 0 | 0 | 3 | 22 | 28 | 0 | 0 | 3 | 24 | 27 | 0 | 0 | 3 | 7 | 5 | 0 | 3 | 7 | 28 | 55 | 0 |
| Placebo | 11 | 30 | 71 | 0 | 3 | 0 | 0 | 2 | 0 | 0 | 0 | 7 | 32 | 0 | 0 | 3 | 21 | 61 | 10 | 0 | 3 | 14 | 57 | 16 | 0 | 3 | 15 | 50 | 21 | 0 | 3 | 7 | 46 | 20 | 0 | 2 | 5 | 42 | 28 | 0 | 2 | 5 | 42 | 28 | 0 | 0 | 9 | 29 | 23 | 0 | 0 | 8 | 24 | 23 | 0 | 0 | 10 | 21 | 23 | 0 | 0 | 3 | 5 | 6 | 0 | 5 | 10 | 31 | 45 | 0 |
"An HE event was defined as occurrences of either a West Haven (WH) Grade ≥2 or a WH Grade 1 and asterixis grade increase of 1 (if baseline WH = 0).~The WH criteria are widely used for rating the severity of HE and are summarized below:~Grade 1: trivial lack of awareness, euphoria or anxiety, shortened attention span, impaired performance of addition Grade 2: lethargy or apathy, minimal disorientation for time or place, subtle personality change, inappropriate behavior, impaired performance of subtraction Grade 3: somnolence to semi-stupor but responsive to verbal stimuli, confusion, gross disorientation Grade 4: coma (unresponsive to verbal or noxious stimuli)~Asterixis was assessed after arm and forearm extension along with wrist dorsiflexion for 30 seconds and assigned a grade according to the following criteria:~Grade 1: rare flaps Grade 2: occasional irregular flaps Grade 3: frequent flaps Grade 4: continuous flaps" (NCT00999167)
Timeframe: Part B: 112 Days
| Intervention | participants (Number) |
|---|---|
| HPN-100 | 19 |
| Placebo | 32 |
Secondary efficacy endpoint. The time to the first HE episode during the treatment period was calculated using the Kaplan-Meier method. Subjects who did not experience an HE episode were censored at the time of their last asterixis assessment. Subjects who had no post-randomization data for the primary endpoint were considered to have an HE episode at Day 1. (NCT00999167)
Timeframe: 112 Days
| Intervention | Days (Median) |
|---|---|
| HPN-100 | NA |
| Placebo | NA |
Secondary efficacy endpoint. The total number of HE events during the treatment phase for subjects in the placebo and active arms. (NCT00999167)
Timeframe: 112 Days
| Intervention | HE event (Number) |
|---|---|
| HPN-100 | 35 |
| Placebo | 57 |
Changes from Baseline to Day 56 and the Final Visit were compared between treatment groups using an ANCOVA model for the total index RBANS score ). The index score is a sum of the scores for each of the 5 individual domains (immediate memory, visuospatial/constructional, language, attention). The minimum and maximum total index scores are 40 and 160, respectively; a higher score is better. (NCT00999167)
Timeframe: Day 56, Final Visit (D112)
| Intervention | units on a scale (Least Squares Mean) | |
|---|---|---|
| Change from Baseline to D56 (Total Score) | Change from Baseline to Final Visit (Total Score) | |
| HPN-100 | -0.5 | -10.7 |
| Placebo | 3.2 | -9.7 |
Part A: The rate of AEs and tolerability of 6 mL and 9 mL doses of HPN-100 were considered the primary safety endpoints for Part A. Safety assessments included adverse events, laboratory tests (including ammonia, hematology, coagulation, liver function and serum chemistry parameters), vital signs, physical and neurological examinations, and electrocardiograms. (NCT00999167)
Timeframe: Part A: 28 days
| Intervention | Subjects (Number) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Any AE | Gastrointestinal disorders | Metabolism and nutrition disorders | Infection and infestations | Nervous system disorders | Blood and lymphatic system disorders | Injury, poisoning and procedural complications | Musculoskeletal and connective tissue disorders | Psychiatric disorders | Any SAE | Death | |
| HPN-100 BID | 11 | 9 | 7 | 4 | 4 | 2 | 2 | 2 | 2 | 5 | 2 |
Total driving errors at the end of drug/placebo. Minimum is zero, maximum is not defined. Higher number indicates greater errors. (NCT00533910)
Timeframe: 8 weeks
| Intervention | raw number of driving errors (Mean) |
|---|---|
| Placebo | 7.6 |
| Rifaximin | 5.5 |
Z score of combined cognitive tests at end of rifaximin/placebo; higher scores indicate better psychometric test performance (NCT00533910)
Timeframe: 8 weeks
| Intervention | Z scores (Mean) |
|---|---|
| Placebo | 0.46 |
| Rifaximin | 1.19 |
Total score ranging from 0 through >100 at the end of drug/placebo. Higher score indicates worse QOL (NCT00533910)
Timeframe: 8 weeks
| Intervention | score on a scale (Mean) |
|---|---|
| Placebo | 12 |
| Rifaximin | 10 |
To evaluate the effect of OCR-002 on ammonia levels in patients with acute liver failure/severe acute liver injury (NCT01548690)
Timeframe: Baseline and 72 Hours
| Intervention | Percent Change (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 41.2 |
| Maximum Dose Level 6.65 g/24h | 16.6 |
| Maximum Dose Level 10 g/24h | 41.8 |
| Maximum Dose Level 20g/24h | 38.4 |
To evaluate the steady state pharmacokinetic and pharmacodynamic profile of OCR-002 in patients with impaired and intact renal function using urinary phenylacetylglutamine (PAGN) as a surrogate marker (NCT01548690)
Timeframe: 24 Hours after last infusion
| Intervention | micrograms per millileter (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 65.6 |
| Maximum Dose Level 6.65 g/24h | 32.2 |
| Maximum Dose Level 10 g/24h | 33.4 |
| Maximum Dose Level 20g/24h | 104.9 |
The orientation log focuses on orientation to place, time, and circumstance. There are 10 items on the orientation log, which are scored 0-3. A spontaneous correct response is awarded 3 points. A spontaneous response that is lacking or incorrect, but a correct response is provided following a logical cue is awarded 2 points. A score of 1 is given if spontaneous and cued responses are lacking or incorrect, but a correct response is provided in a recognition format. A score of 0 is given if the spontaneous, cued, or recognition format does not generate a correct answer. Scores from the 10 items are summed and the final score ranges from 0 to 30. (NCT01548690)
Timeframe: 30 Days
| Intervention | units on a scale (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 23.8 |
| Maximum Dose Level 6.65 g/24h | 24.0 |
| Maximum Dose Level 10 g/24h | 24.0 |
| Maximum Dose Level 20g/24h | 24.0 |
The West Haven Criteria (WHC) for Hepatic Encephalopathy measures the severity of encephalopathy and patient's level of consciousness. The scale ranges from 0 to 4; a minimum score of 0 represents a better outcome, and a maximum total score of 4 represents a worse outcome. A score of 0 corresponds to normal consciousness and behavior and normal neurological examination. A score of 1 corresponds to mild lack of awareness, shortened attention span, and impaired addition or subtraction; mild asterixis or tremor. A score of 2 corresponds to lethargy, disorientated or inappropriate behavior, obvious asterixis; slurred speech. A score of 3 corresponds to somnolent but arousable, gross disorientation or bizarre behavior, muscle rigidity and clonus; hyperreflexia. A score of 4 corresponds to coma and decerebrate posturing. (NCT01548690)
Timeframe: 120 hours from start of infusion
| Intervention | units on a scale (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 2.4 |
| Maximum Dose Level 6.65 g/24h | 3.2 |
| Maximum Dose Level 10 g/24h | 1.6 |
| Maximum Dose Level 20g/24h | 1.8 |
To evaluate the safety and tolerability of OCR-002 in patients with acute liver failure/severe acute liver injury (NCT01548690)
Timeframe: 30 Days
| Intervention | Participants (Count of Participants) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 0 |
| Maximum Dose Level 6.65 g/24h | 0 |
| Maximum Dose Level 10 g/24h | 0 |
| Maximum Dose Level 20g/24h | 0 |
"The primary outcome is the type of response observed at 9 months. Response to treatment can be one of the following:~Complete response (CR): Hb > 9 gm/dL and transfusion-independence as defined in DBA~Partial response (PR): Hb < 9 gm/dL and increased reticulocyte count to greater than baseline.~No response (NR): no change in transfusion requirements and no significant change reticulocyte count from baseline~Progression: worsening of disease as defined by the need for more frequent transfusions" (NCT01362595)
Timeframe: 9 Months
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Complete Hematologic Response | Partial hematologic response | No hematologic response | Progression | |
| Leucine | 2 | 5 | 36 | 0 |
(NCT00345605)
Timeframe: Measured after each 1-week treatment period
| Intervention | micromoles/L (Median) |
|---|---|
| High-dose Arginine Alone | 129 |
| Low-dose Arginine Plus Buphenyl | 53 |
(NCT00345605)
Timeframe: Measured after each 1-week treatment period
| Intervention | micromole/l (Median) |
|---|---|
| High-dose Arginine Alone | 69 |
| Low-dose Arginine Plus Buphenyl | 53 |
The result (in seconds) for a prothrombin time performed on a normal individual will vary according to the type of analytical system employed. This is due to the variations between different batches of manufacturer's tissue factor used in the reagent to perform the test. The INR was devised to standardize the results. Each manufacturer assigns an ISI value (International Sensitivity Index) for any tissue factor they manufacture. The ISI value indicates how a particular batch of tissue factor compares to an international reference tissue factor. The ISI is usually between 1.0 and 2.0. The INR is the ratio of a patient's prothrombin time to a normal (control) sample, raised to the power of the ISI value for the analytical system being used. (NCT00345605)
Timeframe: Measured after each 1-week treatment period
| Intervention | seconds (Mean) |
|---|---|
| Low-dose Arginine Plus Buphenyl | 14.2 |
| High Dose Arginine Alone | 13.8 |
(NCT00345605)
Timeframe: Measured after each 1-week treatment period
| Intervention | micromoles/kg/hr (Mean) |
|---|---|
| High-dose Arginine Alone | 215 |
| Low-dose Arginine Plus Buphenyl | 97 |
Plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured. (NCT00345605)
Timeframe: Measured after each 1-week treatment period
| Intervention | IU/L (Mean) | |
|---|---|---|
| Plasma AST | ALT | |
| High Dose Arginine Alone | 52 | 57.86 |
| Low-dose Arginine Plus Buphenyl | 36.2 | 31.7 |
Plasma levels of coagulation factors I and IX were used as measures of hepatic synthetic function since the treatment duration was short. (NCT00345605)
Timeframe: Measured after each 1-week treatment period
| Intervention | mg/dL (Mean) | |
|---|---|---|
| I | IX | |
| High Dose Arginine Alone | 229.77 | 98.36 |
| Low-dose Arginine Plus Buphenyl | 222.22 | 105.33 |
Prothrombin time (PT) and partial thromboplastin time (PTT) were measured PT measures factors I (fibrinogen), II (prothrombin), V, VII, and X, while PTT is a performance indicator of the efficacy of the common coagulation pathways. (NCT00345605)
Timeframe: Measured after each 1-week treatment period
| Intervention | seconds (Mean) | |
|---|---|---|
| PT | PTT | |
| High Dose Arginine Alone | 13.8 | 30.98 |
| Low-dose Arginine Plus Buphenyl | 14.25 | 30.91 |
287 reviews available for ammonium hydroxide and Hepatic Encephalopathy
| Article | Year |
|---|---|
Serum Ammonia in Cirrhosis: Clinical Impact of Hyperammonemia, Utility of Testing, and National Testing Trends.
Topics: Adult; Ammonia; Hepatic Encephalopathy; Humans; Hyperammonemia; Liver Cirrhosis; Sarcopenia | 2022 |
Amino acids, ammonia, and hepatic encephalopathy.
Topics: Amino Acids; Ammonia; Dietary Proteins; Hepatic Encephalopathy; Humans; Liver Cirrhosis | 2022 |
Hepatic Encephalopathy: Current and Emerging Treatment Modalities.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis | 2022 |
Blood ammonia in patients with chronic liver diseases: A better defined role in clinical practice.
Topics: Ammonia; Brain; Diagnosis, Differential; Hepatic Encephalopathy; Humans; Liver Cirrhosis | 2022 |
Alterations of gut microbiome and effects of probiotic therapy in patients with liver cirrhosis: A systematic review and meta-analysis.
Topics: Ammonia; Bifidobacterium; Gastrointestinal Microbiome; Hepatic Encephalopathy; Humans; Lactobacillus | 2022 |
Cellular Pathogenesis of Hepatic Encephalopathy: An Update.
Topics: Ammonia; Autophagy; Hepatic Encephalopathy; Humans; Hyperammonemia; Liver Failure | 2023 |
A meta-analysis of microbiome therapies for hepatic encephalopathy.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Microbiota; Probiotics; Randomized Controlled Trials as Top | 2023 |
Hepatic Encephalopathy Challenges, Burden, and Diagnostic and Therapeutic Approach.
Topics: Amino Acids, Branched-Chain; Ammonia; Caregivers; Cost of Illness; Dipeptides; Embolization, Therape | 2019 |
Cerebral edema and liver disease: Classic perspectives and contemporary hypotheses on mechanism.
Topics: Ammonia; Animals; Brain; Brain Edema; Hepatic Encephalopathy; Humans; Liver Failure, Acute | 2020 |
Astrocyte swelling in hepatic encephalopathy: molecular perspective of cytotoxic edema.
Topics: Ammonia; Astrocytes; Brain; Brain Edema; Cell Size; Hepatic Encephalopathy; Humans; Hyperammonemia; | 2020 |
Pathophysiology of Hepatic Encephalopathy.
Topics: Ammonia; Animals; Astrocytes; Diabetes Complications; gamma-Aminobutyric Acid; Gastrointestinal Micr | 2020 |
Clinical Manifestations of Hepatic Encephalopathy.
Topics: Ammonia; Cognition Disorders; Dyskinesias; Hepatic Encephalopathy; Humans; Lethargy; Liver Cirrhosis | 2020 |
Laboratory Abnormalities of Hepatic Encephalopathy.
Topics: Ammonia; Brain; Electroencephalography; Hepatic Encephalopathy; Humans; Magnetic Resonance Imaging; | 2020 |
Long-Term Management: Modern Measures to Prevent Readmission in Patients with Hepatic Encephalopathy.
Topics: Ammonia; Disease Progression; Gastrointestinal Agents; Hepatic Encephalopathy; Humans; Liver Cirrhos | 2020 |
Novel Therapies in Hepatic Encephalopathy.
Topics: Acetylcarnitine; Albumins; Ammonia; Dipeptides; Fecal Microbiota Transplantation; Flumazenil; GABA M | 2020 |
Recent advances in understanding and managing hepatic encephalopathy in chronic liver disease.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Inflammation; Quality of Life | 2020 |
The Role of Intestinal Bacteria and Gut-Brain Axis in Hepatic Encephalopathy.
Topics: Ammonia; Bacteria; Brain; Gastrointestinal Microbiome; Hepatic Encephalopathy; Humans | 2020 |
Fecal microbiota transplantation in hepatic encephalopathy: a systematic review.
Topics: Ammonia; Fecal Microbiota Transplantation; Feces; Gastrointestinal Microbiome; Hepatic Encephalopath | 2021 |
Ammonia Removal by Metabolic Scavengers for the Prevention and Treatment of Hepatic Encephalopathy in Cirrhosis.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Hyperammonemia; Liver Cirrhosis | 2021 |
Is a liver biopsy necessary to diagnose hemodialysis-related portal-systemic encephalopathy (HRPSE)? A proposal of the concise diagnostic criteria for HRPSE.
Topics: Adult; Aged; Aged, 80 and over; Ammonia; Biomarkers; Biopsy; Female; Hepatic Encephalopathy; Humans; | 2018 |
Hepatic encephalopathy: a critical current review.
Topics: Albumins; Ammonia; Anti-Bacterial Agents; Bile Acids and Salts; Brain; Brain Edema; Cognitive Dysfun | 2018 |
Roles of Glutamate and Glutamine Transport in Ammonia Neurotoxicity: State of the Art and Question Marks.
Topics: Amino Acid Transport System X-AG; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutra | 2018 |
Effect of probiotic treatment on cirrhotic patients with minimal hepatic encephalopathy: A meta-analysis.
Topics: Adult; Aged; Ammonia; Biomarkers; Chi-Square Distribution; Disease Progression; Endotoxins; Female; | 2018 |
Why and when to measure ammonemia in cirrhosis?
Topics: Ammonia; Diagnosis, Differential; Hepatic Encephalopathy; Humans; Hyperammonemia; Liver Cirrhosis; L | 2018 |
Mechanistic insight, diagnosis, and treatment of ammonia-induced hepatic encephalopathy.
Topics: Ammonia; Diet; Glutamine; Hepatic Encephalopathy; Humans; Urea | 2019 |
Is sarcopenia associated with hepatic encephalopathy in liver cirrhosis? A systematic review and meta-analysis.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver; Liver Cirrhosis; Muscle, Skeletal; Sarcopenia | 2019 |
[Helicobacter pylori and hepatic encephalopathy].
Topics: Ammonia; Helicobacter Infections; Helicobacter pylori; Hepatic Encephalopathy; Humans; Liver Cirrhos | 2018 |
Acetyl-L-carnitine for patients with hepatic encephalopathy.
Topics: Acetylcarnitine; Ammonia; Chelating Agents; Fatigue; Female; Hepatic Encephalopathy; Humans; Liver C | 2019 |
Hepatic Encephalopathy in Cirrhosis: Pathology and Pathophysiology.
Topics: Ammonia; Basal Ganglia; Cerebellum; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Inflamm | 2019 |
Pharmacokinetic and Pharmacodynamic Properties of L-Ornithine L-Aspartate (LOLA) in Hepatic Encephalopathy.
Topics: Ammonia; Animals; Brain; Dipeptides; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Humans; Liver | 2019 |
L-Ornithine L-Aspartate (LOLA) for Hepatic Encephalopathy in Cirrhosis: Results of Randomized Controlled Trials and Meta-Analyses.
Topics: Ammonia; Dipeptides; Hepatic Encephalopathy; Humans; Liver; Liver Cirrhosis; Meta-Analysis as Topic; | 2019 |
Updates on the pathophysiology and therapeutic targets for hepatic encephalopathy.
Topics: Amino Acids, Aromatic; Amino Acids, Branched-Chain; Ammonia; Dipeptides; Fecal Microbiota Transplant | 2019 |
Sarcopenia: Ammonia metabolism and hepatic encephalopathy.
Topics: Ammonia; Exercise Therapy; Follistatin; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Muscle Prot | 2019 |
Effect of L-carnitine on liver enzymes and biochemical factors in hepatic encephalopathy: A systematic review and meta-analysis.
Topics: Alanine Transaminase; Ammonia; Aspartate Aminotransferases; Bilirubin; Blood Urea Nitrogen; Carnitin | 2019 |
l-ornithine-l-aspartate for hepatic encephalopathy in patients with cirrhosis: a meta-analysis of randomized controlled trials.
Topics: Ammonia; Dipeptides; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Randomized Controlled Trials a | 2013 |
Gut microbiota and hepatic encephalopathy.
Topics: Ammonia; Animals; Hepatic Encephalopathy; Humans; Inflammation; Intestines; Microbiota; Probiotics | 2013 |
Update on cerebral uptake of blood ammonia.
Topics: Algorithms; Ammonia; Animals; Blood-Brain Barrier; Brain; Brain Chemistry; Cerebrovascular Circulati | 2013 |
Efficacy of liver assisting in patients with hepatic encephalopathy with special focus on plasma exchange.
Topics: Ammonia; Chemical and Drug Induced Liver Injury; Hepatic Encephalopathy; Humans; Liver Failure; Live | 2013 |
Inflammation and hepatic encephalopathy.
Topics: Ammonia; Animals; Brain; Endotoxemia; Gastrointestinal Tract; Hepatic Encephalopathy; Humans; Inflam | 2013 |
Synaptic plasticity in hepatic encephalopathy - a molecular perspective.
Topics: Ammonia; Animals; Brain; Hepatic Encephalopathy; Humans; Neuronal Plasticity; Receptors, AMPA; Recep | 2013 |
Brain metabolism in patients with hepatic encephalopathy studied by PET and MR.
Topics: Ammonia; Brain; Brain Edema; Hepatic Encephalopathy; Humans; Liver; Liver Cirrhosis; Magnetic Resona | 2013 |
Branched-chain amino acids and ammonia metabolism in liver disease: therapeutic implications.
Topics: Amino Acids, Branched-Chain; Ammonia; Animals; Disease Models, Animal; Glutamine; Hepatic Encephalop | 2013 |
Association of Helicobacter pylori infection with hepatic encephalopathy risk: a systematic review.
Topics: Ammonia; Helicobacter Infections; Helicobacter pylori; Hepatic Encephalopathy; Humans; Liver Cirrhos | 2013 |
Contributions of microdialysis to new alternative therapeutics for hepatic encephalopathy.
Topics: Ammonia; Animals; Hepatic Encephalopathy; Humans; Hyperammonemia; Liver; Liver Cirrhosis; Microdialy | 2013 |
Effects of oral branched-chain amino acids on hepatic encephalopathy and outcome in patients with liver cirrhosis.
Topics: Administration, Oral; Amino Acids; Amino Acids, Branched-Chain; Ammonia; Dietary Supplements; Hepati | 2013 |
Evidence of a vicious cycle in glutamine synthesis and breakdown in pathogenesis of hepatic encephalopathy-therapeutic perspectives.
Topics: Amino Acids, Branched-Chain; Ammonia; Brain; Critical Illness; Drug Interactions; Enterocytes; Gluta | 2014 |
α-Ketoglutaramate: an overlooked metabolite of glutamine and a biomarker for hepatic encephalopathy and inborn errors of the urea cycle.
Topics: Amidohydrolases; Aminohydrolases; Ammonia; Animals; Biomarkers; Carbon; Glutamine; Hepatic Encephalo | 2014 |
Recent insights into the pathogenesis of hepatic encephalopathy and treatments.
Topics: Ammonia; Anti-Bacterial Agents; Hemofiltration; Hepatic Encephalopathy; Humans; Hypothermia, Induced | 2014 |
Treatment of hyperammonemia in liver failure.
Topics: Ammonia; Brain; Glycerol; Hepatic Encephalopathy; Humans; Hyperammonemia; Lactulose; Phenylbutyrates | 2014 |
Pathophysiology of cerebral oedema in acute liver failure.
Topics: Ammonia; Animals; Astrocytes; Blood-Brain Barrier; Brain; Brain Edema; Capillary Permeability; Disea | 2013 |
Cerebral effects of ammonia in liver disease: current hypotheses.
Topics: Ammonia; Animals; Astrocytes; Blood-Brain Barrier; Brain Edema; Diffusion; Energy Metabolism; gamma- | 2014 |
Measurement and interpretation of plasma ammonia.
Topics: Ammonia; Chronic Disease; Hepatic Encephalopathy; Humans; Hyperammonemia; Liver Diseases | 2014 |
Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy.
Topics: Ammonia; Animals; Brain; Brain Edema; Citric Acid Cycle; Dichloroacetic Acid; Drug Evaluation, Precl | 2014 |
Pharmacotherapy for hyperammonemia.
Topics: Ammonia; Animals; Gastrointestinal Agents; Hepatic Encephalopathy; Humans; Hyperammonemia; Lactulose | 2014 |
Concise review of current concepts on nomenclature and pathophysiology of hepatic encephalopathy.
Topics: Ammonia; Cognition; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Mangan | 2014 |
Ammonia and amino acid profiles in liver cirrhosis: effects of variables leading to hepatic encephalopathy.
Topics: Amino Acids, Aromatic; Amino Acids, Branched-Chain; Ammonia; Brain; Dietary Proteins; Glutamine; Hep | 2015 |
Pathophysiology, diagnosis, and management of hepatic encephalopathy.
Topics: Ammonia; Anti-Bacterial Agents; Anti-Inflammatory Agents; Hepatic Encephalopathy; Humans; Inflammati | 2014 |
Systematic review with network meta-analysis: the comparative effectiveness and safety of interventions in patients with overt hepatic encephalopathy.
Topics: Amino Acids, Branched-Chain; Ammonia; Dipeptides; Disaccharides; Gastrointestinal Agents; Hepatic En | 2015 |
Refining the ammonia hypothesis: a physiology-driven approach to the treatment of hepatic encephalopathy.
Topics: Ammonia; Clinical Protocols; Hepatic Encephalopathy; Humans; Hyperammonemia | 2015 |
Diagnosis and Treatment of Low-Grade Hepatic Encephalopathy.
Topics: Accidental Falls; Ammonia; Carnitine; Cognition Disorders; Electroencephalography; Gastrointestinal | 2015 |
New Methods of Testing and Brain Imaging in Hepatic Encephalopathy: A Review.
Topics: Ammonia; Electroencephalography; Hepatic Encephalopathy; Humans; Magnetic Resonance Spectroscopy; Mo | 2015 |
The Role of Sarcopenia and Frailty in Hepatic Encephalopathy Management.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Liver Transplantation; Sarcopenia | 2015 |
Novel Ammonia-Lowering Agents for Hepatic Encephalopathy.
Topics: Ammonia; Carbon; Gastrointestinal Agents; Glycerol; Hepatic Encephalopathy; Humans; Ornithine; Oxide | 2015 |
Ammonia and Its Role in the Pathogenesis of Hepatic Encephalopathy.
Topics: Ammonia; Animals; Astrocytes; Blood-Brain Barrier; Chronic Disease; gamma-Aminobutyric Acid; Glutami | 2015 |
Treatment of Overt Hepatic Encephalopathy.
Topics: Amino Acids, Branched-Chain; Ammonia; Arteriovenous Fistula; Dipeptides; Gastrointestinal Agents; Gl | 2015 |
Diagnosis and Management of Hepatic Encephalopathy in Fulminant Hepatic Failure.
Topics: Acetylcysteine; Ammonia; Brain Edema; Free Radical Scavengers; Gastrointestinal Agents; Hepatic Ence | 2015 |
Clinical science workshop: targeting the gut-liver-brain axis.
Topics: Ammonia; Animals; Anti-Inflammatory Agents; Brain; Drug Delivery Systems; Education; Gastrointestina | 2016 |
Pathogenesis of hepatic encephalopathy in cirrhosis: the concept of synergism revisited.
Topics: Ammonia; Animals; Antioxidants; Energy Metabolism; Glutamate-Ammonia Ligase; Hepatic Encephalopathy; | 2016 |
Hepatic Encephalopathy: Pharmacological Therapies Targeting Ammonia.
Topics: Ammonia; Animals; Chelating Agents; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Liver, Artifici | 2016 |
Multifactorial Effects on Different Types of Brain Cells Contribute to Ammonia Toxicity.
Topics: Ammonia; Animals; Astrocytes; Brain; Cyclic GMP; Energy Metabolism; Glutamine; Hepatic Encephalopath | 2017 |
Neurotoxicity of Ammonia.
Topics: Ammonia; Animals; Astrocytes; Brain; Cell Size; Hepatic Encephalopathy; Humans; Mitochondria; Reacti | 2017 |
Current state of knowledge of hepatic encephalopathy (part III): non-absorbable disaccharides.
Topics: Ammonia; Animals; Disaccharides; Gastrointestinal Agents; Health Knowledge, Attitudes, Practice; Hep | 2016 |
Current state of knowledge of hepatic encephalopathy (part I): newer treatment strategies for hyperammonemia in liver failure.
Topics: Ammonia; Animals; Glutamate-Ammonia Ligase; Health Knowledge, Attitudes, Practice; Hepatic Encephalo | 2016 |
Hepatic encephalopathy: Ever closer to its big bang.
Topics: Ammonia; Animals; Disease Progression; Hepatic Encephalopathy; Humans; Intestinal Mucosa; Intestines | 2016 |
Ammonia toxicity: from head to toe?
Topics: Ammonia; Animals; Brain; Brain Chemistry; Hepatic Encephalopathy; Humans; Hyperammonemia; Muscle, Sk | 2017 |
Hepatic Encephalopathy.
Topics: Ammonia; Animals; Anti-Bacterial Agents; Cat Diseases; Cats; Dog Diseases; Dogs; Hepatic Encephalopa | 2017 |
The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema.
Topics: Ammonia; Animals; Brain; Brain Edema; Hepatic Encephalopathy; Humans; Hyperammonemia; Intracranial H | 2009 |
Thiamine deficiency-related brain dysfunction in chronic liver failure.
Topics: Adult; Aged; Ammonia; Brain; Chronic Disease; Encephalitis; Female; Hepatic Encephalopathy; Humans; | 2009 |
Gut ammonia production and its modulation.
Topics: Ammonia; Animals; Genetic Predisposition to Disease; Glutaminase; Glutamine; Hepatic Encephalopathy; | 2009 |
Identifying the direct effects of ammonia on the brain.
Topics: Adenosine Triphosphatases; Ammonia; Animals; Brain; Cation Transport Proteins; Cell Membrane; Hepati | 2009 |
Signaling factors in the mechanism of ammonia neurotoxicity.
Topics: Ammonia; Animals; Brain; Brain Edema; Calcium Signaling; Hepatic Encephalopathy; Humans; Mitochondri | 2009 |
[Update on the management of hepatic encephalopathy].
Topics: Aged; Ammonia; Anti-Bacterial Agents; Antidotes; Clinical Trials as Topic; Dialysis; Flumazenil; GAB | 2008 |
[Pathogenesis of portal systemic encephalopathy].
Topics: Amino Acids; Ammonia; Animals; Fatty Acids; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; | 1990 |
What is the utility of measuring the serum ammonia level in patients with altered mental status?
Topics: Ammonia; Biomarkers; Cognition Disorders; Hepatic Encephalopathy; Humans; Liver Diseases | 2009 |
Radiotracer imaging studies in hepatic encephalopathy: ISHEN practice guidelines.
Topics: Ammonia; Animals; Hepatic Encephalopathy; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spe | 2009 |
Hepatic encephalopathy: pathophysiology and emerging therapies.
Topics: Ammonia; Anti-Infective Agents; Drug Therapy, Combination; Dyskinesias; Gastrointestinal Agents; Hep | 2009 |
Ammonia and the neutrophil in the pathogenesis of hepatic encephalopathy in cirrhosis.
Topics: Ammonia; Animals; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Neutrophils | 2010 |
Interaction of oxidative stress, astrocyte swelling and cerebral ammonia toxicity.
Topics: Ammonia; Animals; Astrocytes; Brain; Brain Edema; Gene Expression; Hepatic Encephalopathy; Humans; M | 2010 |
Management of hepatic encephalopathy in children.
Topics: Ammonia; Brain Edema; Child; Gastrointestinal Hemorrhage; Hepatic Encephalopathy; Humans; Infections | 2010 |
Hepatic encephalopathy: current management strategies and treatment, including management and monitoring of cerebral edema and intracranial hypertension in fulminant hepatic failure.
Topics: Ammonia; Brain Edema; Hepatic Encephalopathy; Humans; Intracranial Hypertension; Liver Failure, Acut | 2010 |
The Na-K-Cl Co-transporter in astrocyte swelling.
Topics: Ammonia; Animals; Astrocytes; Brain; Brain Edema; Cell Size; Disease Models, Animal; Hepatic Encepha | 2010 |
Pharmacotherapy of hepatic encephalopathy in cirrhosis.
Topics: Ammonia; Anti-Bacterial Agents; Fluid Therapy; Flumazenil; Hepatic Encephalopathy; Humans; Intestina | 2010 |
Clinical management of hepatic encephalopathy.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Practice Guidelines as Topic; Treatment Ou | 2010 |
Treatment options for hepatic encephalopathy.
Topics: Ammonia; Anti-Infective Agents; Clinical Trials as Topic; Female; Gastrointestinal Agents; Hepatic E | 2010 |
[Pathogenesis and diagnosis of subclinical hepatic encephalopathy].
Topics: Ammonia; Brain; Brain Edema; Hepatic Encephalopathy; Humans; Liver Failure; Neuropsychological Tests | 2010 |
Changing face of hepatic encephalopathy: role of inflammation and oxidative stress.
Topics: Ammonia; Animals; Astrocytes; Brain; Cognition Disorders; Hepatic Encephalopathy; Humans; Immunity, | 2010 |
Acute liver failure.
Topics: Acetaminophen; Ammonia; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Emergency | 2010 |
Glutamine as a mediator of ammonia neurotoxicity: A critical appraisal.
Topics: Ammonia; Animals; Astrocytes; Brain; Cyclic GMP; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; H | 2010 |
Interorgan ammonia metabolism in liver failure: the basis of current and future therapies.
Topics: Adipose Tissue; Amino Acids; Ammonia; Arginine; Brain; Dipeptides; Glutamate-Ammonia Ligase; Glutami | 2011 |
Mechanisms, diagnosis and management of hepatic encephalopathy.
Topics: Ammonia; Gastrointestinal Agents; Gastrointestinal Tract; Hepatic Encephalopathy; Humans; Lactulose; | 2010 |
Hepatic encephalopathy: from pathophysiology to therapeutic management.
Topics: Ammonia; Anti-Bacterial Agents; Benzodiazepines; Blood-Brain Barrier; Cerebral Cortex; Disaccharides | 2011 |
Acute-on-chronic liver failure: the brain.
Topics: Ammonia; Brain; End Stage Liver Disease; Hepatic Encephalopathy; Humans; Liver Failure, Acute | 2011 |
To pee or not to pee: ammonia hypothesis of hepatic encephalopathy revisited.
Topics: Ammonia; Animals; Brain; Hepatic Encephalopathy; Humans; Intestinal Mucosa; Kidney; Liver; Liver Fai | 2011 |
Detoxification as a treatment goal in hepatic failure.
Topics: Ammonia; Brain Edema; Extracorporeal Circulation; Hepatic Encephalopathy; Humans; Liver Failure, Acu | 2011 |
Clinical efficacy and safety of lactulose for minimal hepatic encephalopathy: a meta-analysis.
Topics: Adult; Ammonia; Diarrhea; Disease Progression; Hepatic Encephalopathy; Humans; Lactulose; Neuropsych | 2011 |
Brain energy metabolism and mitochondrial dysfunction in acute and chronic hepatic encephalopathy.
Topics: Acute Disease; Ammonia; Brain; Chronic Disease; Citric Acid Cycle; Energy Metabolism; Glycolysis; He | 2012 |
Determination of ammonia concentrations in cirrhosis patients-still confusing after all these years?
Topics: Ammonia; Breath Tests; Diagnostic Tests, Routine; Hepatic Encephalopathy; Humans; Liver Cirrhosis; N | 2011 |
Critical analysis of studies evaluating the efficacy of infusion of L-ornithine L-aspartate in clinical hepatic encephalopathy in patients with liver failure.
Topics: Adult; Aged; Ammonia; Dipeptides; Hepatic Encephalopathy; Humans; Infusions, Intravenous; Liver Fail | 2011 |
Management of overt hepatic encephalopathy.
Topics: Acarbose; Ammonia; Disease Management; Gastrointestinal Agents; Hepatic Encephalopathy; Humans; Lact | 2012 |
Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure: role of glutamine redefined.
Topics: Ammonia; Biological Transport; Brain; Brain Edema; Glutamine; Hepatic Encephalopathy; Humans; Liver | 2012 |
Hepatic encephalopathy.
Topics: Ammonia; Benzodiazepines; Dietary Supplements; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Huma | 2012 |
[Hepatic encephalopathy and liver transplantation].
Topics: Ammonia; Anti-Infective Agents; Colon; Dipeptides; Disaccharides; End Stage Liver Disease; Evidence- | 2012 |
Hepatic encephalopathy.
Topics: Ammonia; Anti-Bacterial Agents; Antidotes; Charcoal; Gastrointestinal Agents; Hepatic Encephalopathy | 2012 |
[Hepatic encephalopathy].
Topics: Amino Acids, Branched-Chain; Ammonia; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Automobil | 2012 |
Ammonia-lowering strategies for the treatment of hepatic encephalopathy.
Topics: Ammonia; Brain; Hepatic Encephalopathy; Humans; Hyperammonemia; Liver | 2012 |
Possible treatment of end-stage hyperammonemic encephalopathy by inhibition of glutamine synthetase.
Topics: Ammonia; Animals; Brain; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Hepatic Encephalopathy; Homeos | 2013 |
Pathogenesis of hepatic encephalopathy: lessons from nitrogen challenges in man.
Topics: Amino Acids; Ammonia; Animals; Colon; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Nit | 2013 |
Liver-brain proinflammatory signalling in acute liver failure: role in the pathogenesis of hepatic encephalopathy and brain edema.
Topics: Ammonia; Animals; Blood-Brain Barrier; Brain; Brain Edema; Cytokines; Hepatic Encephalopathy; Humans | 2013 |
Systemic inflammation and ammonia in hepatic encephalopathy.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Immunity, Innate; Inflammation; Liver Failure; Systemic Inf | 2013 |
Prevention and treatment of hepatic encephalopathy: focusing on gut microbiota.
Topics: Ammonia; Anti-Bacterial Agents; Clinical Trials as Topic; Gastroenterology; Hepatic Encephalopathy; | 2012 |
Glutamine in the pathogenesis of hepatic encephalopathy: the trojan horse hypothesis revisited.
Topics: Ammonia; Animals; Astrocytes; Glutamine; Hepatic Encephalopathy; Humans; Mitochondria; Stress, Physi | 2014 |
Current pathogenetic aspects of hepatic encephalopathy and noncirrhotic hyperammonemic encephalopathy.
Topics: Ammonia; Animals; Blood-Brain Barrier; Brain; Brain Edema; gamma-Aminobutyric Acid; Hepatic Encephal | 2013 |
Role of branched chain amino acids in cerebral ammonia homeostasis related to hepatic encephalopathy.
Topics: Amino Acids, Branched-Chain; Ammonia; Animals; Citric Acid Cycle; Energy Metabolism; Hepatic Encepha | 2013 |
Mechanisms of hyperammonemia.
Topics: Amino Acids; Ammonia; Animals; Brain; Hepatic Encephalopathy; Humans; Hyperammonemia | 2002 |
Extracorporeal treatment in fulminant hepatic failure: pathophysiologic considerations.
Topics: Ammonia; Animals; Brain Edema; Cerebrovascular Circulation; Glutamine; Hepatic Encephalopathy; Human | 2002 |
Management of hepatic encephalopathy.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Precipitating Factors | 2002 |
Pathophysiology of hepatic encephalopathy: a new look at ammonia.
Topics: Ammonia; Brain; Hepatic Encephalopathy; Humans; Liver Failure | 2002 |
Ammonia, the GABA neurotransmitter system, and hepatic encephalopathy.
Topics: Ammonia; Animals; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Neurotransmitter Agents; | 2002 |
Positron emission tomography in the study of hepatic encephalopathy.
Topics: Ammonia; Benzodiazepines; Brain; Glucose; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Neuropsyc | 2002 |
Clinical efficacy of L-ornithine-L-aspartate in the management of hepatic encephalopathy.
Topics: Ammonia; Dipeptides; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Muscular Diseases; Severity of | 2002 |
The molecular pathogenesis of hepatic encephalopathy.
Topics: Ammonia; Animals; Astrocytes; Brain; Gene Expression Regulation; Glutamine; Hepatic Encephalopathy; | 2003 |
Helicobacter pylori infection in patients with liver cirrhosis: facts and fictions.
Topics: Ammonia; Anti-Ulcer Agents; Drug Therapy, Combination; Helicobacter Infections; Helicobacter pylori; | 2003 |
Hepatic encephalopathy and Helicobacter pylori: a critical reappraisal.
Topics: Ammonia; Animals; Case-Control Studies; Gastric Juice; Helicobacter pylori; Hepatic Encephalopathy; | 2003 |
HEPATIC COMA.
Topics: Ammonia; Anti-Bacterial Agents; Arginine; Blood; Diagnosis; Diagnosis, Differential; Diuretics; Gast | 1964 |
CHEMICAL THERAPY OF CIRRHOSIS.
Topics: Ammonia; Ascites; Diuretics; Drug Therapy; Hepatic Encephalopathy; Liver Cirrhosis; Metabolism; Toxi | 1964 |
CHEMISTRY OF AMMONIA INTOXICATION.
Topics: Ammonia; Arginine; Carboxy-Lyases; Glutamine; Hepatic Encephalopathy; Kidney; Metabolism; Neurologic | 1964 |
Pathogenesis of hepatic encephalopathy in acute liver failure.
Topics: Ammonia; Brain; Brain Edema; Cerebrovascular Circulation; Hepatic Encephalopathy; Humans; Liver Cirr | 2003 |
[Hepatic encephalopathy].
Topics: Alcoholism; Amino Acids, Branched-Chain; Ammonia; Blood-Brain Barrier; Embolization, Therapeutic; He | 2003 |
[Hepatic encephalopathy--diagnostics].
Topics: Ammonia; Brain; Brain Chemistry; Chronic Disease; Diagnosis, Differential; Electroencephalography; H | 2003 |
[Hepatic encephalopathy--therapy].
Topics: Administration, Oral; Ammonia; Anti-Bacterial Agents; Diet, Protein-Restricted; Dipeptides; Flumazen | 2003 |
[Hepatic encephalopathy].
Topics: Ammonia; Biomarkers; Dementia; Diagnosis, Differential; Electroencephalography; Hepatic Encephalopat | 2004 |
[Chronic portal-systemic encephalopathy].
Topics: Ammonia; Biomarkers; Chronic Disease; Dementia; Diagnosis, Differential; Diagnostic Imaging; Hepatic | 2004 |
Assessing the severity of hepatic encephalopathy.
Topics: Ammonia; Diagnostic Imaging; Electroencephalography; Evoked Potentials, Somatosensory; Hepatic Encep | 2003 |
Pathogenesis of hepatic encephalopathy: update on molecular mechanisms.
Topics: Ammonia; Brain; Chronic Disease; Diagnostic Imaging; Hepatic Encephalopathy; Humans; Liver Failure; | 2003 |
Newer aspects of hepatic encephalopathy.
Topics: Ammonia; Animals; Anti-Bacterial Agents; Enkephalins; GABA Modulators; Gastrointestinal Agents; Hepa | 2003 |
Helicobacter pylori and hepatic encephalopathy.
Topics: Ammonia; Gastric Juice; Helicobacter Infections; Helicobacter pylori; Hepatic Encephalopathy; Humans | 2003 |
Role of gut bacteria in the therapy of hepatic encephalopathy with lactulose and antibiotics.
Topics: Ammonia; Anti-Bacterial Agents; Bacteria; Dietary Fiber; Drug Therapy, Combination; Gastrointestinal | 2003 |
[Ammonia and GABA-ergic neurotransmission in pathogenesis of hepatic encephalopathy].
Topics: Ammonia; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Neurotransmitter Agents; Receptors | 2003 |
[New concepts in the physiopathology of hepatic encephalopathy and therapeutic prospects].
Topics: Ammonia; Brain; Brain Edema; Dipeptides; Flumazenil; Glutaminase; Glutamine; Hepatic Encephalopathy; | 2004 |
Hepatic encephalopathy--a serious complication of alcoholic liver disease.
Topics: Ammonia; Animals; Hepatic Encephalopathy; Humans; Liver Diseases, Alcoholic; Manganese | 2003 |
Ammonia neurotoxicity and the mitochondrial permeability transition.
Topics: Ammonia; Animals; Apoptosis; Astrocytes; Cell Membrane; Cell Membrane Permeability; Hepatic Encephal | 2004 |
Functional imaging of the brain in patients with liver cirrhosis.
Topics: Ammonia; Brain; Cognition Disorders; Glucose; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Posit | 2004 |
Blood ammonia levels and hepatic encephalopathy.
Topics: Ammonia; Animals; Blood Chemical Analysis; Blood-Brain Barrier; Brain; Diffusion; Gases; Hepatic Enc | 2004 |
Oxidative stress in the pathogenesis of hepatic encephalopathy.
Topics: Ammonia; Animals; Astrocytes; Brain; Glutamine; Hepatic Encephalopathy; Humans; Nerve Degeneration; | 2004 |
Portal systemic encephalopathy.
Topics: Ammonia; Blood-Brain Barrier; Hepatic Encephalopathy; Humans; Indoles; Neurotransmitter Agents; Port | 1997 |
Neuroimaging in hepatic encephalopathy.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy | 2005 |
Management of hepatic encephalopathy: role of rifaximin.
Topics: Ammonia; Animals; Anti-Bacterial Agents; Antidepressive Agents; Bacteria; Benzodiazepines; Clinical | 2005 |
Cerebral metabolic disturbances in the brain during acute liver failure: from hyperammonemia to energy failure and proteolysis.
Topics: Ammonia; Animals; Astrocytes; Cerebral Cortex; Citric Acid Cycle; Hepatic Encephalopathy; Humans; Hy | 2005 |
Pathophysiological basis of therapy of raised intracranial pressure in acute liver failure.
Topics: Ammonia; Animals; Brain Edema; Cerebrovascular Circulation; Encephalitis; Hepatic Encephalopathy; Hu | 2005 |
Role of antibiotics in the management of hepatic encephalopathy.
Topics: Ammonia; Anti-Bacterial Agents; Bacteria; Hepatic Encephalopathy; Humans; Intestines | 2005 |
The pathophysiologic basis of hepatic encephalopathy: central role for ammonia and inflammation.
Topics: Ammonia; Astrocytes; Hepatic Encephalopathy; Humans; Inflammation | 2005 |
Ammonia and hepatic encephalopathy: the more things change, the more they remain the same.
Topics: Ammonia; Animals; Hepatic Encephalopathy; Humans | 2005 |
Hepatic encephalopathy: from pathophysiology to treatment.
Topics: Ammonia; Anti-Bacterial Agents; Antipsychotic Agents; Brain; Hepatic Encephalopathy; Humans; Neurotr | 2006 |
Glutamine: a Trojan horse in ammonia neurotoxicity.
Topics: Ammonia; Astrocytes; Glutamine; Hepatic Encephalopathy; Humans; Mitochondria; Oxidative Stress | 2006 |
Glutamine: a Trojan horse in ammonia neurotoxicity.
Topics: Ammonia; Astrocytes; Glutamine; Hepatic Encephalopathy; Humans; Mitochondria; Oxidative Stress | 2006 |
Glutamine: a Trojan horse in ammonia neurotoxicity.
Topics: Ammonia; Astrocytes; Glutamine; Hepatic Encephalopathy; Humans; Mitochondria; Oxidative Stress | 2006 |
Glutamine: a Trojan horse in ammonia neurotoxicity.
Topics: Ammonia; Astrocytes; Glutamine; Hepatic Encephalopathy; Humans; Mitochondria; Oxidative Stress | 2006 |
Glutamine: a Trojan horse in ammonia neurotoxicity.
Topics: Ammonia; Astrocytes; Glutamine; Hepatic Encephalopathy; Humans; Mitochondria; Oxidative Stress | 2006 |
Glutamine: a Trojan horse in ammonia neurotoxicity.
Topics: Ammonia; Astrocytes; Glutamine; Hepatic Encephalopathy; Humans; Mitochondria; Oxidative Stress | 2006 |
Glutamine: a Trojan horse in ammonia neurotoxicity.
Topics: Ammonia; Astrocytes; Glutamine; Hepatic Encephalopathy; Humans; Mitochondria; Oxidative Stress | 2006 |
Glutamine: a Trojan horse in ammonia neurotoxicity.
Topics: Ammonia; Astrocytes; Glutamine; Hepatic Encephalopathy; Humans; Mitochondria; Oxidative Stress | 2006 |
Glutamine: a Trojan horse in ammonia neurotoxicity.
Topics: Ammonia; Astrocytes; Glutamine; Hepatic Encephalopathy; Humans; Mitochondria; Oxidative Stress | 2006 |
Myth: interpretation of a single ammonia level in patients with chronic liver disease can confirm or rule out hepatic encephalopathy.
Topics: Ammonia; Chronic Disease; Hepatic Encephalopathy; Humans; Liver Diseases | 2006 |
Management of hepatic encephalopathy in patients with cirrhosis.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Liver Transplantation | 2007 |
Review article: bacterial flora and pathogenesis in hepatic encephalopathy.
Topics: Ammonia; Anti-Bacterial Agents; Bacterial Infections; Female; Hepatic Encephalopathy; Humans; Intest | 2007 |
The effect of hyperventilation upon cerebral blood flow and metabolism in patients with fulminant hepatic failure.
Topics: Acetaminophen; Ammonia; Analgesics, Non-Narcotic; Animals; Carbon Dioxide; Cerebrovascular Circulati | 2007 |
[Disturbances in ammonia metabolism in hepatic failure].
Topics: Ammonia; Animals; Brain; Hepatic Encephalopathy; Humans; Hyperammonemia; Intestinal Mucosa; Kidney; | 2007 |
The anaplerotic flux and ammonia detoxification in hepatic encephalopathy.
Topics: Ammonia; Animals; Astrocytes; Brain; Citric Acid Cycle; Energy Metabolism; Glucose; Glutamine; Hepat | 2007 |
The neurosteroid system: an emerging therapeutic target for hepatic encephalopathy.
Topics: Ammonia; Animals; Brain; Desoxycorticosterone; Hepatic Encephalopathy; Humans; Isoquinolines; Mangan | 2007 |
New findings on cerebral ammonia uptake in HE using functional (13)N-ammonia PET.
Topics: Ammonia; Blood-Brain Barrier; Brain; Cerebrovascular Circulation; Hepatic Encephalopathy; Humans; Ni | 2007 |
Mechanisms of brain edema in acute liver failure and impact of novel therapeutic interventions.
Topics: Ammonia; Animals; Brain; Brain Diseases, Metabolic; Brain Edema; Energy Metabolism; Glutamine; Hepat | 2007 |
Brain edema in acute liver failure.
Topics: Ammonia; Brain Edema; Critical Care; Hepatic Encephalopathy; Humans; Liver Failure, Acute; Prognosis | 2008 |
Hepatic encephalopathy.
Topics: Ammonia; Brain; Diagnosis, Differential; Disaccharides; Hepatic Encephalopathy; Humans; Liver Cirrho | 2008 |
[Pathogenesis of hepatic coma].
Topics: Amines; Amino Acids; Amino Acids, Sulfur; Ammonia; Brain; Catecholamines; Fatty Acids; Hepatic Encep | 1981 |
Biochemical mechanisms of hepatic encephalopathy.
Topics: Amino Acids; Ammonia; Bile Acids and Salts; Blood-Brain Barrier; Brain; Fatty Acids; gamma-Aminobuty | 1983 |
Nutritional management of hepatic encephalopathy.
Topics: Amino Acids; Amino Acids, Branched-Chain; Ammonia; Animals; Brain; Dietary Proteins; Food, Formulate | 1983 |
[Therapy of hepatic encephalopathy. Personal experience and a review of the literature].
Topics: Amino Acids; Ammonia; Bromocriptine; Electroencephalography; Fatty Acids; Hepatic Encephalopathy; La | 1982 |
Amino acid imbalance and hepatic encephalopathy.
Topics: Amino Acids; Amino Acids, Branched-Chain; Ammonia; Animals; Blood-Brain Barrier; Brain; Catecholamin | 1982 |
Pathophysiology of hepatic encephalopathy.
Topics: Amino Acids; Ammonia; Animals; Blood-Brain Barrier; Brain; Brain Edema; Evoked Potentials, Visual; F | 1984 |
[Metabolic disorders in hepatic encephalopathy].
Topics: Amino Acids; Ammonia; Brain; Energy Metabolism; Hepatic Encephalopathy; Humans; Ketoglutaric Acids; | 1984 |
[Hepatic encephalopathy and selective amino acid solutions].
Topics: Amino Acids; Amino Acids, Branched-Chain; Ammonia; Brain Diseases; Fatty Acids; Hepatic Encephalopat | 1983 |
Hepatic encephalopathy evaluation.
Topics: Ammonia; Dietary Proteins; Electroencephalography; Hepatic Encephalopathy; Humans; Liver Cirrhosis; | 1983 |
Methods for assessing hepatic encephalopathy.
Topics: Ammonia; Brain; Brain Diseases; Diagnosis, Differential; Electroencephalography; Evoked Potentials, | 1983 |
Progress in the treatment of chronic portasystemic encephalopathy.
Topics: Amino Acids, Branched-Chain; Ammonia; Animals; Bromocriptine; Chronic Disease; Clinical Trials as To | 1984 |
Treatment of hepatic coma with an L-valine supplement to full parenteral nutrition.
Topics: Ammonia; Brain; Hepatic Encephalopathy; Humans; Parenteral Nutrition; Tryptophan; Valine | 1981 |
Fulminant viral hepatitis.
Topics: Acid-Base Imbalance; Acute Disease; Acute Kidney Injury; Adrenal Cortex Hormones; Amino Acids; Ammon | 1980 |
[On the neuro-psychiatric symptomatology of the so-called "hepatic coma" (author's transl)].
Topics: Acetoin; Acid-Base Imbalance; Adult; Amino Acids; Ammonia; Biological Transport; Blood Coagulation D | 1981 |
Animal models of hepatic encephalopathy and hyperammonemia.
Topics: Ammonia; Animals; Disease Models, Animal; Hepatic Encephalopathy; Humans | 1994 |
Brain metabolism in encephalopathy caused by hyperammonemia.
Topics: Ammonia; Animals; Brain Chemistry; Hepatic Encephalopathy; Humans | 1994 |
Astrocyte-neuron interactions in hyperammonemia and hepatic encephalopathy.
Topics: Ammonia; Animals; Astrocytes; Hepatic Encephalopathy; Humans; Neurons | 1994 |
Spinal seizures in ammonia intoxication.
Topics: Ammonia; Animals; Cats; Hepatic Encephalopathy; Rats; Seizures; Spinal Cord | 1994 |
Portal-systemic encephalopathy: a disorder of multiple neurotransmitter systems.
Topics: Ammonia; Animals; Biogenic Monoamines; Hepatic Encephalopathy; Humans; Neurotransmitter Agents | 1994 |
Current theories on the pathogenesis of hepatic encephalopathy.
Topics: Ammonia; Animals; Brain; Brain Edema; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hepatic | 1994 |
Inherited and acquired syndromes of hyperammonemia and encephalopathy in children.
Topics: Ammonia; Child; Hepatic Encephalopathy; Humans; Liver Diseases; Metabolism, Inborn Errors; Reye Synd | 1994 |
Endotoxin and tumor necrosis factor-alpha in the pathogenesis of hepatic encephalopathy.
Topics: Amino Acids; Ammonia; Animals; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Lipopolysacc | 1994 |
[Ornithine aspartate in hepatic encephalopathy: an established new therapeutic approach. Overview and results of current randomized studies].
Topics: Ammonia; Dipeptides; Hepatic Encephalopathy; Humans; Liver Function Tests; Randomized Controlled Tri | 1994 |
Awakenings to the pathogenicity of urease and the requirement for continuous long term therapy.
Topics: Ammonia; Animals; Dogs; Helicobacter Infections; Helicobacter pylori; Hepatic Encephalopathy; Humans | 1994 |
Brain metabolism in hepatic encephalopathy and hyperammonemia.
Topics: Adult; Aged; Ammonia; Animals; Brain; Hepatic Encephalopathy; Humans; Middle Aged | 1993 |
Activation of NMDA receptor mediates the toxicity of ammonia and the effects of ammonia on the microtubule-associated protein MAP-2.
Topics: Ammonia; Animals; Brain; Dizocilpine Maleate; Hepatic Encephalopathy; Humans; Microtubule-Associated | 1993 |
[A case of portal-systemic encephalopathy with slowly progressive, non-flapping tremor].
Topics: Ammonia; Disease Progression; Hepatic Encephalopathy; Humans; Male; Middle Aged; Tremor | 1995 |
[Hepatic minimal encephalopathy. The most frequently overlooked, clinically occult "metabolic syndrome" on the cirrhosis patient].
Topics: Ammonia; Arginine; Dipeptides; Hepatic Encephalopathy; Humans; Lactulose; Neuropsychological Tests; | 1996 |
[Hepatic encephalopathy].
Topics: Amino Acids, Branched-Chain; Ammonia; Benzodiazepines; Diagnosis, Differential; gamma-Aminobutyric A | 1995 |
Urea cycle disorders: diagnosis, pathophysiology, and therapy.
Topics: Adolescent; Algorithms; Alkalosis, Respiratory; Amino Acid Metabolism, Inborn Errors; Ammonia; Child | 1996 |
Treatment of hepatic encephalopathy in patients with cirrhosis of the liver.
Topics: Amino Acids, Branched-Chain; Ammonia; Clinical Trials as Topic; gamma-Aminobutyric Acid; Hepatic Enc | 1996 |
Lactulose and combination therapy of hepatic encephalopathy: the role of the intestinal microflora.
Topics: Ammonia; Anti-Bacterial Agents; Bacteria; Cathartics; Dietary Fiber; Drug Synergism; Feces; Gastroin | 1996 |
The contribution of various organs to ammonia formation: a review of factors determining the arterial ammonia concentration.
Topics: Ammonia; Animals; Hepatic Encephalopathy; Humans; Liver; Organ Specificity | 1996 |
Astrocytic-ammonia interactions in hepatic encephalopathy.
Topics: Ammonia; Astrocytes; Brain Edema; Hepatic Encephalopathy; Humans | 1996 |
Effects of lactulose on nitrogen metabolism.
Topics: Ammonia; Animals; Anti-Bacterial Agents; Colon; Dietary Fiber; Feces; Gastrointestinal Agents; Hepat | 1997 |
Ammonia and GABA-ergic neurotransmission: interrelated factors in the pathogenesis of hepatic encephalopathy.
Topics: Ammonia; Animals; Central Nervous System; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; M | 1997 |
Gastritis and Helicobacter pylori: forty years of antibiotic therapy.
Topics: Ammonia; Animals; Anti-Bacterial Agents; Gastric Juice; Gastric Mucosa; Gastritis; Helicobacter Infe | 1997 |
Treatment of hepatic encephalopathy.
Topics: Amino Acids, Branched-Chain; Ammonia; Anti-Bacterial Agents; Diagnosis, Differential; Diet, Protein- | 1997 |
Hepatic encephalopathy in acute liver failure: role of the glutamate system.
Topics: Ammonia; Animals; Biological Transport; Brain; Glutamic Acid; Hepatic Encephalopathy; Liver Failure, | 1997 |
Glutamate and muscarinic receptors in the molecular mechanisms of acute ammonia toxicity and of its prevention.
Topics: Acute Disease; Ammonia; Animals; Glutamic Acid; Hepatic Encephalopathy; Receptors, Glutamate; Recept | 1997 |
The involvement of ammonia with the mechanisms that enhance GABA-ergic neurotransmission in hepatic failure.
Topics: Ammonia; Animals; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Liver Failure; Synaptic T | 1997 |
The peripheral benzodiazepine receptor and neurosteroids in hepatic encephalopathy.
Topics: Ammonia; Animals; Astrocytes; Brain; Cell Size; Hepatic Encephalopathy; Humans; Receptors, GABA-A; S | 1997 |
Hyperammonaemia without portal systemic shunting does not resemble hepatic encephalopathy.
Topics: Amino Acids; Ammonia; Analysis of Variance; Animals; Electroencephalography; Hepatic Encephalopathy; | 1997 |
Neurology and the liver.
Topics: Ammonia; Brain Edema; Cholestasis; Diagnosis, Differential; Fatigue; Flumazenil; GABA Modulators; He | 1997 |
Helicobacter pylori and the liver: any relationship?
Topics: Ammonia; Antibodies, Bacterial; Duodenal Ulcer; Helicobacter Infections; Helicobacter pylori; Hepati | 1998 |
[Adult-onset type II citrullinemia in a patient undergoing continuous ambulatory peritoneal dialysis].
Topics: Ammonia; Argininosuccinate Synthase; Citrulline; Hepatic Encephalopathy; Humans; Liver; Male; Middle | 1998 |
Nutritional support in hepatic encephalopathy.
Topics: Amino Acids; Ammonia; Carbohydrate Metabolism; Dietary Proteins; Hepatic Encephalopathy; Humans; Lip | 1999 |
Positron emission tomography in the study of hepatic encephalopathy.
Topics: Ammonia; Brain; Cerebrovascular Circulation; Glucose; Hepatic Encephalopathy; Humans; Tomography, Em | 1998 |
Astroglial dysfunction in hepatic encephalopathy.
Topics: Ammonia; Animals; Astrocytes; Biological Transport; Glutamic Acid; Hepatic Encephalopathy; Humans; R | 1998 |
Evidence for an astrocytic glutamate transporter deficit in hepatic encephalopathy.
Topics: Amino Acid Transport System X-AG; Ammonia; Animals; Astrocytes; ATP-Binding Cassette Transporters; B | 1999 |
Hepatic encephalopathy: An update of pathophysiologic mechanisms.
Topics: Ammonia; Animals; Brain; Hepatic Encephalopathy; Humans; Manganese; Manganese Poisoning | 1999 |
The astrocytic ("peripheral-type") benzodiazepine receptor: role in the pathogenesis of portal-systemic encephalopathy.
Topics: Ammonia; Animals; Astrocytes; Chronic Disease; Hepatic Encephalopathy; Humans; Liver Failure; Mangan | 2000 |
[Hepatic encephalopathy [acute type, chronic/recurrent type and mixed/terminal coma type]].
Topics: Amino Acids, Branched-Chain; Ammonia; Diagnosis, Differential; Hepatic Encephalopathy; Humans; Liver | 2000 |
[Portal-systemic encephalopathy or shunt encephalopathy].
Topics: Ammonia; Balloon Occlusion; Diagnosis, Differential; Embolization, Therapeutic; Hepatic Encephalopat | 2000 |
Pathogenesis of hepatic encephalopathy.
Topics: Ammonia; gamma-Aminobutyric Acid; Glutamic Acid; Hepatic Encephalopathy; Humans; Liver Failure; Rece | 2000 |
Hepatic encephalopathy.
Topics: Ammonia; Animals; Disease Models, Animal; GABA-A Receptor Agonists; Hepatic Encephalopathy; Humans; | 2001 |
Alterations in expression of genes coding for key astrocytic proteins in acute liver failure.
Topics: Ammonia; Animals; Astrocytes; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glial | 2001 |
Branched chain amino acids in heptatic encephalopathy.
Topics: Amino Acid Transport System L; Amino Acids, Branched-Chain; Ammonia; Animals; Blood-Brain Barrier; B | 2002 |
Pathogenesis and therapy of hepatic coma.
Topics: Amino Acids; Ammonia; Brain; Energy Metabolism; Hepatic Encephalopathy; Neurotransmitter Agents | 1976 |
A summary of biochemical changes and the pathogenesis of liver coma.
Topics: Adenosine Triphosphate; Aminobutyrates; Ammonia; Brain; Coenzyme A; Hepatic Encephalopathy; Humans; | 1976 |
[Cirrhosis and encephalopathy. Attempt at a physiopathologic interpretation].
Topics: Ammonia; Animals; Brain; Energy Metabolism; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Neurotr | 1976 |
Pathogenesis of hepatic coma.
Topics: Adenosine Triphosphate; Amino Acids; Ammonia; Animals; Brain Chemistry; Cell Membrane; Dogs; Fatty A | 1975 |
[Biochemical and pathophysiological aspects of hyperammonaemia (author's transl)].
Topics: Ammonia; Brain; Hepatic Encephalopathy; Humans; Liver; Uracil Nucleotides; Urea | 1977 |
[Effect of severe liver diseases on the central nervous system].
Topics: Ammonia; Central Nervous System; Endotoxins; Hepatic Encephalopathy; Humans; Liver; Liver Diseases; | 1977 |
[Hepatic coma and insufficiency].
Topics: Ammonia; Brain; Electrocardiography; Fatty Acids; Hepatic Encephalopathy; Hepatitis; Humans; Liver; | 1977 |
Hepatic encephalopathy: summary of present knowledge with an elaboration on recent developments.
Topics: Amino Acids; Ammonia; Animals; Brain Chemistry; Dogs; Hepatic Encephalopathy; Humans; Levodopa; Rats | 1979 |
[Physiopathology of ammonia].
Topics: Ammonia; Body Fluids; Brain; Hepatic Encephalopathy; Humans; Metabolic Diseases | 1976 |
[Hepatic encephalopathy and magnesium deficiency states].
Topics: Ammonia; Animal Feed; Animals; Cattle; Dietary Proteins; Electroencephalography; Hepatic Encephalopa | 1975 |
Experimental liver diseases.
Topics: Alkaloids; Ammonia; Animals; Bilirubin; Budd-Chiari Syndrome; Carbon Tetrachloride Poisoning; Cattle | 1975 |
Hepatic encephalopathy: a disorder in glial-neuronal communication.
Topics: Ammonia; Animals; Astrocytes; Brain Edema; Calcium; Cell Size; Cells, Cultured; Cyclic AMP; Cytoskel | 1992 |
Management of hepatic encephalopathy (HE) in companion animal medicine.
Topics: Amino Acids; Ammonia; Animals; Brain; Cat Diseases; Cats; Dog Diseases; Dogs; Glutamates; Hepatic En | 1992 |
Pathogenesis and treatment of portal-systemic encephalopathy: an update.
Topics: Ammonia; Animals; Hepatic Encephalopathy; Humans; Neurotransmitter Agents; Receptors, GABA-A | 1992 |
Recent developments in the pathophysiology and treatment of hepatic encephalopathy.
Topics: Ammonia; Brain; Fatty Acids; Hepatic Encephalopathy; Humans; Hypertension, Portal; Liver Cirrhosis; | 1992 |
The pathogenesis and treatment of hepatic encephalopathy: evidence for the involvement of benzodiazepine receptor ligands.
Topics: Ammonia; Animals; Disease Models, Animal; Flumazenil; Hepatic Encephalopathy; Humans; Ligands; Neuro | 1991 |
Neurochemistry of hepatic encephalopathy.
Topics: Ammonia; Benzodiazepines; Brain; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans | 1991 |
Role of nutrition in hepatic encephalopathy.
Topics: Ammonia; Diet; Diet Therapy; Dietary Proteins; Enteral Nutrition; Fatty Acids, Nonesterified; Hepati | 1991 |
New roles of carnitine metabolism in ammonia cytotoxicity.
Topics: Ammonia; Animals; Carnitine; Cell Survival; Hepatic Encephalopathy; Humans | 1990 |
Effects of NH4+ on the function of the CNS.
Topics: Ammonia; Animals; Brain; Cell Membrane; Hepatic Encephalopathy; Humans; Neurons | 1990 |
[Advances in research on mechanisms of hepatic encephalopathy].
Topics: Amino Acids; Ammonia; Animals; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans | 1989 |
[Changes in and modulation of receptor activity in hepatic encephalopathy].
Topics: Ammonia; Animals; Aspartic Acid; Binding, Competitive; Biogenic Amines; Blood-Brain Barrier; Brain; | 1985 |
Hepatic encephalopathy: a neurochemical disorder.
Topics: Amino Acids; Ammonia; Animals; Blood-Brain Barrier; Enterobacteriaceae; Evoked Potentials; gamma-Ami | 1986 |
[Hepatic encephalopathies].
Topics: Ammonia; Brain; Hepatic Encephalopathy; Humans; Neurotransmitter Agents; Receptors, Neurotransmitter | 1987 |
[Hepatic encephalopathy. Pathogenetic evaluation and current possibilities of treatment].
Topics: Amino Acids; Ammonia; Blood-Brain Barrier; Emergencies; Esophageal and Gastric Varices; Fatty Acids; | 1985 |
Hepatic encephalopathy.
Topics: Ammonia; Animals; Blood-Brain Barrier; Brain; Demyelinating Diseases; Fatty Acids; Glutamine; Hepati | 1985 |
Hepatic encephalopathy: pathogenesis.
Topics: Amino Acids; Ammonia; Animals; Blood-Brain Barrier; Fatty Acids; gamma-Aminobutyric Acid; Hepatic En | 1988 |
[Nosography and pathophysiology of hepatic encephalopathy].
Topics: Amino Acids; Ammonia; Fatty Acids, Volatile; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans | 1986 |
Conditional deficiencies of ornithine or arginine.
Topics: Amino Acids; Amino Acids, Branched-Chain; Ammonia; Animals; Arginine; Citrulline; Female; Glycine; H | 1986 |
[Intracellular amino acid concentrations in the musculature of 3 species of animals under physiologic, pathophysiologic and infusion therapy conditions].
Topics: Amino Acids; Ammonia; Animals; Cats; Hepatic Encephalopathy; Humans; Muscles; Parenteral Nutrition, | 1987 |
The acyl-CoA dehydrogenation deficiencies. Recent advances in the enzymic characterization and understanding of the metabolic and pathophysiological disturbances in patients with acyl-CoA dehydrogenation deficiencies.
Topics: Acidosis; Acyl Coenzyme A; Acyl-CoA Dehydrogenase, Long-Chain; Ammonia; Carboxylic Acids; Chemical P | 1985 |
Pathophysiology of chronic hepatic encephalopathy.
Topics: Amines; Amino Acids; Ammonia; Animals; Blood-Brain Barrier; Chronic Disease; Dogs; gamma-Aminobutyri | 1985 |
Hepatic coma in cirrhosis, portal hypertension, and following portacaval shunt. Its etiologies and the current status of its treatment.
Topics: Acute Disease; Amino Acids; Ammonia; Brain; Chronic Disease; Colon; Dietary Proteins; Fatty Acids; G | 1974 |
[New development in the study of infectious hepatitis].
Topics: Acute Disease; Acute Kidney Injury; Alkalosis; Ammonia; Clinical Enzyme Tests; Dihydroxyphenylalanin | 1973 |
Haemodialysis in the treatment of liver failure.
Topics: Ammonia; Exchange Transfusion, Whole Blood; Hepatic Encephalopathy; Humans; Liver Diseases; Perfusio | 1968 |
[Inhibition of urease activity by hydroxamic acid and its practical application].
Topics: Ammonia; Animal Feed; Antifungal Agents; Bacteria; Borates; Chemical Phenomena; Chemistry; Chloromer | 1972 |
Lactulose: a review of its therapeutic and pharmacological properties with particular reference to ammonia metabolism and its mode of action of portal systemic encephalopathy.
Topics: Adult; Aged; Ammonia; Animals; Constipation; Disaccharides; Electroencephalography; Feces; Female; H | 1972 |
Hepatic coma: present concepts of pathogenesis and therapy.
Topics: Adrenal Cortex Hormones; Amino Acids; Ammonia; Animals; Anti-Bacterial Agents; Biogenic Amines; Brai | 1972 |
Hepatic encephalopathy.
Topics: Acetazolamide; Ammonia; Constipation; Diet Therapy; Electroencephalography; Gastrointestinal Hemorrh | 1973 |
Recognition and management of acute and chronic hepatic encephalopathy.
Topics: Acute Disease; Amines; Ammonia; Animals; Brain Edema; Central Nervous System; Chronic Disease; Diet | 1973 |
Hepatic encephalopathy: current status.
Topics: Adrenal Cortex Hormones; Amino Acids; Ammonia; Animals; Anti-Bacterial Agents; Biogenic Amines; Dihy | 1974 |
[Emergency treatment of hepatic coma and porto-caval encephalopathy].
Topics: Acidosis; Alkalosis; Ammonia; Anti-Bacterial Agents; Brain Diseases; Diuretics; Emergencies; Glucose | 1973 |
[Metabolic anomaly and management of hepatic coma].
Topics: Adrenal Cortex Hormones; Ammonia; Catecholamines; Dihydroxyphenylalanine; Electrolytes; Exchange Tra | 1973 |
Effects of lysine on ammonia formation, hydrogen ion, and potassium ion balance: a review and an hypothesis.
Topics: Acid-Base Equilibrium; Adolescent; Adult; Ammonia; Animals; Arginine; Biological Transport; Cystinur | 1973 |
Fulminant viral hepatitis.
Topics: Acute Disease; Acute Kidney Injury; Amino Acids; Ammonia; Animals; Brain; Brain Diseases; Brain Edem | 1974 |
Ammonium metabolism and hepatic coma.
Topics: Ammonia; Hepatic Encephalopathy; Humans | 1967 |
[Hepatic coma--clinical aspects and biochemistry].
Topics: Alkalosis; Ammonia; Glucose; Glutamine; Hepatic Encephalopathy; Humans; Hydrogen-Ion Concentration; | 1968 |
[Biochemistry of hepatic coma].
Topics: Ammonia; Brain; Brain Chemistry; Citric Acid Cycle; Glutamates; Hepatic Encephalopathy; Humans; Musc | 1969 |
[Treatment of hepatic coma].
Topics: Ammonia; Anti-Bacterial Agents; Antifibrinolytic Agents; Diet Therapy; Exchange Transfusion, Whole B | 1969 |
[Development of hepatic coma].
Topics: Ammonia; Carbohydrate Metabolism; Central Nervous System; Electroencephalography; Hepatic Encephalop | 1969 |
[Current aspects of hepatic oma therapy].
Topics: Ammonia; Anti-Bacterial Agents; Colectomy; Colon; Diet Therapy; Exchange Transfusion, Whole Blood; G | 1969 |
[Exchange transfusion in the therapy of acute hepatic coma].
Topics: Acute Disease; Ammonia; Bilirubin; Blood Glucose; Exchange Transfusion, Whole Blood; Hepatic Encepha | 1969 |
Hepatic encephalopathy.
Topics: Ammonia; Animals; Anti-Bacterial Agents; Arginine; Chemical and Drug Induced Liver Injury; Colectomy | 1964 |
Treatment of ammonia intoxication by exclusion of the colon.
Topics: Ammonia; Colon; Hepatic Encephalopathy; Humans | 1966 |
96 trials available for ammonium hydroxide and Hepatic Encephalopathy
| Article | Year |
|---|---|
L-ornithine L-aspartate in acute treatment of severe hepatic encephalopathy: A double-blind randomized controlled trial.
Topics: Ammonia; Aspartic Acid; Hepatic Encephalopathy; Humans; Lactulose; Liver Cirrhosis; Ornithine; Rifax | 2022 |
Pharmacokinetics/pharmacodynamics of L-ornithine phenylacetate in overt hepatic encephalopathy and the effect of plasma ammonia concentration reduction on clinical outcomes.
Topics: Adult; Ammonia; Hepatic Encephalopathy; Humans; Ornithine; Phenylacetates | 2022 |
Letter to the editor: l-ornithine l-aspartate in acute treatment of severe hepatic encephalopathy: A double-blind randomized controlled trial.
Topics: Ammonia; Aspartic Acid; Dipeptides; Double-Blind Method; Hepatic Encephalopathy; Humans; Ornithine | 2022 |
Influence of shunt occlusion on liver volume and functions in hyperammonemic cirrhosis patients having large porto-systemic shunts: a randomized control trial.
Topics: Ammonia; Balloon Occlusion; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Treatment Outcome | 2023 |
Clearance and production of ammonia quantified in humans by constant ammonia infusion - the effects of cirrhosis and ammonia-targeting treatments.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Hyperammonemia; Lactulose; Liver Cirrhosis; Male; Phenylbut | 2023 |
Clinical study of probiotics combined with lactulose for minimal hepatic encephalopathy treatment.
Topics: Ammonia; Glycation End Products, Advanced; Hepatic Encephalopathy; Humans; Lactulose; Liver Cirrhosi | 2023 |
Nutritional therapy for persistent cognitive impairment after resolution of overt hepatic encephalopathy in patients with cirrhosis: A double-blind randomized controlled trial.
Topics: Adult; Ammonia; Cognitive Dysfunction; Endotoxins; Hepatic Encephalopathy; Humans; Liver Cirrhosis; | 2023 |
A novel nomogram predicting overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in portal hypertension patients.
Topics: Ammonia; Creatinine; Hepatic Encephalopathy; Humans; Hypertension, Portal; Indocyanine Green; Nomogr | 2023 |
Efficacy and Safety of Sodium Benzoate in The Management of Hyperammonemia in Decompensated Chronic Liver Disease of the Childhood-A Double-blind Randomized Controlled Trial.
Topics: Ammonia; Child; Double-Blind Method; Hepatic Encephalopathy; Humans; Hyperammonemia; Prospective Stu | 2020 |
[Effect of Acupuncture at Thirteen Evil Acupoints on Liver Function, and the Contents of Blood Ammonia and β-endorphin in Patients with Hepatic Encephalopathy].
Topics: Acupuncture Points; Acupuncture Therapy; Ammonia; beta-Endorphin; Hepatic Encephalopathy; Humans | 2017 |
Impact of intestinal mannitol on hyperammonemia, oxidative stress and severity of hepatic encephalopathy in the ED.
Topics: Adult; Ammonia; Biomarkers; Diuretics, Osmotic; Drug Administration Routes; End Stage Liver Disease; | 2018 |
Secondary prophylaxis of hepatic encephalopathy in cirrhosis of liver: a double-blind randomized controlled trial of L-ornithine L-aspartate versus placebo.
Topics: Adult; Ammonia; Biomarkers; Chi-Square Distribution; Dipeptides; Double-Blind Method; Female; Flicke | 2018 |
Role of probiotics in the treatment of minimal hepatic encephalopathy in patients with HBV-induced liver cirrhosis.
Topics: Adult; Ammonia; China; Cognition Disorders; Female; Gastrointestinal Microbiome; Hepatic Encephalopa | 2018 |
Rifaximin versus metronidazole in management of acute episode of hepatic encephalopathy: An open labeled randomized clinical trial.
Topics: Acute Disease; Adult; Ammonia; Anti-Infective Agents; Female; Hepatic Encephalopathy; Humans; Length | 2018 |
Serum endotoxin, inflammatory mediators, and magnetic resonance spectroscopy before and after treatment in patients with minimal hepatic encephalopathy.
Topics: Adolescent; Adult; Aged; Ammonia; Biomarkers; Endotoxins; Female; Gastrointestinal Agents; Hepatic E | 2013 |
Lactulose is highly potential in prophylaxis of hepatic encephalopathy in patients with cirrhosis and upper gastrointestinal bleeding: results of a controlled randomized trial.
Topics: Adult; Aged; Ammonia; Female; Gastrointestinal Hemorrhage; Hepatic Encephalopathy; Humans; Lactulose | 2013 |
Randomized, double-blind, controlled study of glycerol phenylbutyrate in hepatic encephalopathy.
Topics: Adult; Aged; Ammonia; Double-Blind Method; Female; Glutamine; Glycerol; Hepatic Encephalopathy; Huma | 2014 |
Randomized, double-blind, controlled study of glycerol phenylbutyrate in hepatic encephalopathy.
Topics: Adult; Aged; Ammonia; Double-Blind Method; Female; Glutamine; Glycerol; Hepatic Encephalopathy; Huma | 2014 |
Randomized, double-blind, controlled study of glycerol phenylbutyrate in hepatic encephalopathy.
Topics: Adult; Aged; Ammonia; Double-Blind Method; Female; Glutamine; Glycerol; Hepatic Encephalopathy; Huma | 2014 |
Randomized, double-blind, controlled study of glycerol phenylbutyrate in hepatic encephalopathy.
Topics: Adult; Aged; Ammonia; Double-Blind Method; Female; Glutamine; Glycerol; Hepatic Encephalopathy; Huma | 2014 |
Can Lactobacillus acidophilus improve minimal hepatic encephalopathy? A neurometabolite study using magnetic resonance spectroscopy.
Topics: Adult; Ammonia; Brain; Choline; Creatinine; Female; Gastrointestinal Agents; Gastrointestinal Tract; | 2013 |
Randomised clinical trial: L-ornithine-L-aspartate reduces significantly the increase of venous ammonia concentration after TIPSS.
Topics: Adult; Ammonia; Dipeptides; Female; Hepatic Encephalopathy; Humans; Kidney Function Tests; Liver Fun | 2014 |
Fasting Blood Ammonia Predicts Risk and Frequency of Hepatic Encephalopathy Episodes in Patients With Cirrhosis.
Topics: Ammonia; Double-Blind Method; Fasting; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Models, Stat | 2016 |
Prevalence of Helicobacter pylori Infection in Patients with Minimal Hepatic Encephalopathy.
Topics: Aged; Ammonia; Biomarkers; Female; Germany; Helicobacter Infections; Helicobacter pylori; Hepatic En | 2016 |
Randomized controlled trial comparing lactulose plus albumin versus lactulose alone for treatment of hepatic encephalopathy.
Topics: Adult; Albumins; Ammonia; Biomarkers; Drug Therapy, Combination; Endotoxins; Female; Hepatic Encepha | 2017 |
Value of the apparent diffusion coefficient for quantification of low-grade hepatic encephalopathy.
Topics: Aged; Ammonia; Brain; Cohort Studies; Diffusion Magnetic Resonance Imaging; Female; Hepatic Encephal | 2008 |
Probiotic yogurt for the treatment of minimal hepatic encephalopathy.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Interleukin-6; Middle Aged; Patient Compliance; Probiotics; | 2008 |
L-ornithine-L-aspartate infusion efficacy in hepatic encephalopathy.
Topics: Adult; Aged; Ammonia; Cognition; Dipeptides; Female; Health Status Indicators; Hepatic Encephalopath | 2008 |
Branched chain amino acids supplemented with L-acetylcarnitine versus BCAA treatment in hepatic coma: a randomized and controlled double blind study.
Topics: Acetylcarnitine; Amino Acids, Branched-Chain; Ammonia; Double-Blind Method; Electroencephalography; | 2009 |
Bifidobacterium combined with fructo-oligosaccharide versus lactulose in the treatment of patients with hepatic encephalopathy.
Topics: Adult; Ammonia; Bifidobacterium; Cognition; Double-Blind Method; Female; Hepatic Encephalopathy; Hum | 2010 |
A double-blind, randomized, placebo-controlled trial of intravenous L-ornithine-L-aspartate on postural control in patients with cirrhosis.
Topics: Aged; Ammonia; Biopsy, Needle; Dipeptides; Dose-Response Relationship, Drug; Double-Blind Method; Dr | 2010 |
Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy.
Topics: Ammonia; Anti-Infective Agents; Automobile Driving; Cognition; Cytokines; Hepatic Encephalopathy; Hu | 2011 |
Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy.
Topics: Ammonia; Anti-Infective Agents; Automobile Driving; Cognition; Cytokines; Hepatic Encephalopathy; Hu | 2011 |
Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy.
Topics: Ammonia; Anti-Infective Agents; Automobile Driving; Cognition; Cytokines; Hepatic Encephalopathy; Hu | 2011 |
Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy.
Topics: Ammonia; Anti-Infective Agents; Automobile Driving; Cognition; Cytokines; Hepatic Encephalopathy; Hu | 2011 |
Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy.
Topics: Ammonia; Anti-Infective Agents; Automobile Driving; Cognition; Cytokines; Hepatic Encephalopathy; Hu | 2011 |
Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy.
Topics: Ammonia; Anti-Infective Agents; Automobile Driving; Cognition; Cytokines; Hepatic Encephalopathy; Hu | 2011 |
Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy.
Topics: Ammonia; Anti-Infective Agents; Automobile Driving; Cognition; Cytokines; Hepatic Encephalopathy; Hu | 2011 |
Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy.
Topics: Ammonia; Anti-Infective Agents; Automobile Driving; Cognition; Cytokines; Hepatic Encephalopathy; Hu | 2011 |
Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy.
Topics: Ammonia; Anti-Infective Agents; Automobile Driving; Cognition; Cytokines; Hepatic Encephalopathy; Hu | 2011 |
Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study.
Topics: Acetylcarnitine; Adult; Aged; Ammonia; Double-Blind Method; Fatigue; Female; Hepatic Encephalopathy; | 2011 |
The effect of L-ornithine L-aspartate and branch chain amino acids on encephalopathy and nutritional status in liver cirrhosis with malnutrition.
Topics: Adult; Aged; Albumins; Amino Acids, Branched-Chain; Ammonia; Dietary Proteins; Dipeptides; Double-Bl | 2011 |
Role of Helicobacter pylori infection in the pathogenesis of minimal hepatic encephalopathy and effect of its eradication.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Ammonia; Anti-Bacterial Agents; Clarithromycin; Drug | 2011 |
A randomized controlled trial comparing lactulose, probiotics, and L-ornithine L-aspartate in treatment of minimal hepatic encephalopathy.
Topics: Adult; Ammonia; Dipeptides; Female; Hepatic Encephalopathy; Humans; Lactulose; Male; Middle Aged; Ne | 2011 |
Acetyl-L-carnitine improves cognitive functions in severe hepatic encephalopathy: a randomized and controlled clinical trial.
Topics: Acetylcarnitine; Adult; Alanine Transaminase; Ammonia; Bilirubin; Cognition; Double-Blind Method; El | 2011 |
Secondary prophylaxis of hepatic encephalopathy in cirrhosis: an open-label, randomized controlled trial of lactulose, probiotics, and no therapy.
Topics: Adolescent; Adult; Aged; Ammonia; Analysis of Variance; Chi-Square Distribution; Female; Gastrointes | 2012 |
Treatment with a potassium-iron-phosphate-citrate complex improves PSE scores and quality of life in patients with minimal hepatic encephalopathy: a multicenter, randomized, placebo-controlled, double-blind clinical trial.
Topics: Adult; Aged; Ammonia; Analysis of Variance; Citrates; Double-Blind Method; Female; Germany; Hepatic | 2013 |
MARS (Molecular Adsorbent Recirculating System): experience in 34 cases of acute liver failure.
Topics: Adult; Ammonia; Bilirubin; Female; Hepatic Encephalopathy; Humans; Liver Failure, Acute; Male; Middl | 2002 |
Molecular Adsorbent Recirculating System: clinical experience in patients with liver failure based on hepatitis B in China.
Topics: Ammonia; Bilirubin; China; Creatinine; Hemoglobins; Hepatic Encephalopathy; Hepatitis B; Humans; Liv | 2002 |
Comparison of rifaximin and lactitol in the treatment of acute hepatic encephalopathy: results of a randomized, double-blind, double-dummy, controlled clinical trial.
Topics: Acute Disease; Ammonia; Anti-Infective Agents; Double-Blind Method; Electroencephalography; Female; | 2003 |
Correlation between ammonia levels and the severity of hepatic encephalopathy.
Topics: Adult; Aged; Ammonia; Biomarkers; Blood Chemical Analysis; Blood Pressure Determination; Female; Hep | 2003 |
[Long-term efficacy of lactulose in patients with subclinical hepatic encephalopathy].
Topics: Adult; Aged; Ammonia; Evoked Potentials, Somatosensory; Female; Gastrointestinal Agents; Hepatic Enc | 2003 |
[Effects of lactulose treatment on the course of subclinical hepatic encephalopathy].
Topics: Administration, Oral; Adult; Aged; Ammonia; Evoked Potentials, Somatosensory; Female; Gastrointestin | 2003 |
A 3-year experience with Molecular Adsorbent Recirculating System (MARS): our results on 63 patients with hepatic failure and color Doppler US evaluation of cerebral perfusion.
Topics: Adult; Albumins; Ammonia; Bilirubin; Cerebrovascular Circulation; Female; Hepatic Encephalopathy; Hu | 2003 |
Oral tryptophan challenge studies in cirrhotic patients: no evidence of neuropsychiatric changes.
Topics: Aged; Ammonia; Electroencephalography; Female; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Male | 2003 |
L-Carnitine in the treatment of mild or moderate hepatic encephalopathy.
Topics: Ammonia; Carnitine; Double-Blind Method; Female; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Ma | 2003 |
Reversal of diuretic-induced hepatic encephalopathy with infusion of albumin but not colloid.
Topics: Adult; Ammonia; Diuretics; Female; Fluid Therapy; Gelatin; Hemodynamics; Hepatic Encephalopathy; Hum | 2004 |
Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis.
Topics: Adult; Aged; Ammonia; Dietary Fiber; Endotoxins; Feces; Female; Fermentation; Hepatic Encephalopathy | 2004 |
Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis.
Topics: Adult; Aged; Ammonia; Dietary Fiber; Endotoxins; Feces; Female; Fermentation; Hepatic Encephalopathy | 2004 |
Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis.
Topics: Adult; Aged; Ammonia; Dietary Fiber; Endotoxins; Feces; Female; Fermentation; Hepatic Encephalopathy | 2004 |
Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis.
Topics: Adult; Aged; Ammonia; Dietary Fiber; Endotoxins; Feces; Female; Fermentation; Hepatic Encephalopathy | 2004 |
Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis.
Topics: Adult; Aged; Ammonia; Dietary Fiber; Endotoxins; Feces; Female; Fermentation; Hepatic Encephalopathy | 2004 |
Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis.
Topics: Adult; Aged; Ammonia; Dietary Fiber; Endotoxins; Feces; Female; Fermentation; Hepatic Encephalopathy | 2004 |
Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis.
Topics: Adult; Aged; Ammonia; Dietary Fiber; Endotoxins; Feces; Female; Fermentation; Hepatic Encephalopathy | 2004 |
Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis.
Topics: Adult; Aged; Ammonia; Dietary Fiber; Endotoxins; Feces; Female; Fermentation; Hepatic Encephalopathy | 2004 |
Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis.
Topics: Adult; Aged; Ammonia; Dietary Fiber; Endotoxins; Feces; Female; Fermentation; Hepatic Encephalopathy | 2004 |
Normal protein diet for episodic hepatic encephalopathy: results of a randomized study.
Topics: Aged; Ammonia; Bilirubin; Diet, Protein-Restricted; Dietary Proteins; Female; Hepatic Encephalopathy | 2004 |
Breath ammonia testing for diagnosis of hepatic encephalopathy.
Topics: Ammonia; Breath Tests; Equipment Design; Female; Hepatic Encephalopathy; Humans; Male; Middle Aged; | 2005 |
Improvement of hepatic encephalopathy using a modified high-calorie high-protein diet.
Topics: Adolescent; Adult; Aged; Ammonia; Dietary Proteins; Female; Hepatic Encephalopathy; Humans; Liver Ci | 2005 |
Effects of L-carnitine in patients with hepatic encephalopathy.
Topics: Adult; Ammonia; Carnitine; Double-Blind Method; Female; Hepatic Encephalopathy; Humans; Male; Middle | 2005 |
Amino acid challenge in patients with cirrhosis and control subjects: ammonia, plasma amino acid and EEG changes.
Topics: Adult; Aged; Amino Acids; Ammonia; Electroencephalography; Female; Hepatic Encephalopathy; Humans; L | 2006 |
Effects of L-acetylcarnitine on cirrhotic patients with hepatic coma: randomized double-blind, placebo-controlled trial.
Topics: Acetylcarnitine; Adult; Ammonia; Blood Urea Nitrogen; Double-Blind Method; Electroencephalography; F | 2006 |
Role of ammonia and inflammation in minimal hepatic encephalopathy.
Topics: Adult; Aged; Amino Acids; Ammonia; Biomarkers; C-Reactive Protein; Female; Hepatic Encephalopathy; H | 2007 |
Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study.
Topics: Alanine Transaminase; Ammonia; Aspartate Aminotransferases; Bifidobacterium; Chronic Disease; Double | 2007 |
Sensitivity and specificity of bispectral index for classification of overt hepatic encephalopathy: a multicentre, observer blinded, validation study.
Topics: Aged; Ammonia; Female; Hepatic Encephalopathy; Hepatitis C, Chronic; Humans; Male; Middle Aged; Sens | 2008 |
Sensitivity and specificity of bispectral index for classification of overt hepatic encephalopathy: a multicentre, observer blinded, validation study.
Topics: Aged; Ammonia; Female; Hepatic Encephalopathy; Hepatitis C, Chronic; Humans; Male; Middle Aged; Sens | 2008 |
Sensitivity and specificity of bispectral index for classification of overt hepatic encephalopathy: a multicentre, observer blinded, validation study.
Topics: Aged; Ammonia; Female; Hepatic Encephalopathy; Hepatitis C, Chronic; Humans; Male; Middle Aged; Sens | 2008 |
Sensitivity and specificity of bispectral index for classification of overt hepatic encephalopathy: a multicentre, observer blinded, validation study.
Topics: Aged; Ammonia; Female; Hepatic Encephalopathy; Hepatitis C, Chronic; Humans; Male; Middle Aged; Sens | 2008 |
Acetyl-L-carnitine treatment in minimal hepatic encephalopathy.
Topics: Acetylcarnitine; Adult; Ammonia; Bilirubin; Cognition; Double-Blind Method; Female; Hepatic Encephal | 2008 |
An open-label randomized controlled trial of lactulose and probiotics in the treatment of minimal hepatic encephalopathy.
Topics: Adult; Ammonia; Drug Therapy, Combination; Event-Related Potentials, P300; Female; Hepatic Encephalo | 2008 |
Progress in the treatment of chronic portasystemic encephalopathy.
Topics: Amino Acids, Branched-Chain; Ammonia; Animals; Bromocriptine; Chronic Disease; Clinical Trials as To | 1984 |
Dietary protein supplementation from vegetable sources in the management of chronic portal systemic encephalopathy.
Topics: Adult; Amino Acids; Ammonia; Chronic Disease; Clinical Trials as Topic; Dietary Proteins; Electroenc | 1984 |
Increased plasma ammonia may inhibit cellular release of branched-chain amino acids in systemic portal encephalopathy.
Topics: Adult; Amino Acids; Amino Acids, Branched-Chain; Ammonia; Biological Transport; Blood; Combined Moda | 1983 |
Branched-chain amino acids vs lactulose in the treatment of hepatic coma: a controlled study.
Topics: Amino Acids; Amino Acids, Branched-Chain; Ammonia; Clinical Trials as Topic; Disaccharides; Glucose; | 1982 |
Branched-chain amino acids vs lactulose in the treatment of hepatic coma: a controlled study.
Topics: Amino Acids; Amino Acids, Branched-Chain; Ammonia; Clinical Trials as Topic; Disaccharides; Glucose; | 1982 |
Branched-chain amino acids vs lactulose in the treatment of hepatic coma: a controlled study.
Topics: Amino Acids; Amino Acids, Branched-Chain; Ammonia; Clinical Trials as Topic; Disaccharides; Glucose; | 1982 |
Branched-chain amino acids vs lactulose in the treatment of hepatic coma: a controlled study.
Topics: Amino Acids; Amino Acids, Branched-Chain; Ammonia; Clinical Trials as Topic; Disaccharides; Glucose; | 1982 |
Treatment of chronic portal--systemic encephalopathy with vegetable and animal protein diets. A controlled crossover study.
Topics: Adult; Ammonia; Animals; Chronic Disease; Clinical Trials as Topic; Diabetes Complications; Dietary | 1982 |
The use of ornithine salts of branched-chain ketoacids in portal-systemic encephalopathy.
Topics: Adult; Aged; Amino Acids; Amino Acids, Branched-Chain; Ammonia; Calcium; Clinical Trials as Topic; D | 1980 |
Treatment of hepatic encephalopathy with metronidazole.
Topics: Aged; Ammonia; Clinical Trials as Topic; Double-Blind Method; Electroencephalography; Female; Hepati | 1982 |
Oral keto analogs of branched-chain amino acids in hyperammonemia in patients with cirrhosis of the liver. A double-blind crossover study.
Topics: Administration, Oral; Adult; Aged; Amino Acids, Branched-Chain; Ammonia; Double-Blind Method; Electr | 1982 |
Therapy of portal-systemic encephalopathy: the practical and the promising.
Topics: Amino Acids; Ammonia; Bacteria; Enema; Hepatic Encephalopathy; Humans; Intestines; Lactulose; Neomyc | 1981 |
Rifaximin in the treatment of chronic hepatic encephalopathy.
Topics: Adult; Aged; Aged, 80 and over; Ammonia; Analysis of Variance; Anti-Bacterial Agents; Chronic Diseas | 1995 |
[The treatment of hepatic encephalopathy with Hepa-Mertz].
Topics: Ammonia; Biomarkers; Chronic Disease; Dipeptides; Hepatic Encephalopathy; Humans; Liver Cirrhosis; P | 1995 |
Effects of long-term administration of low-dose lactitol in patients with cirrhosis but without overt encephalopathy.
Topics: Aged; Ammonia; Dose-Response Relationship, Drug; Electroencephalography; Female; Hepatic Encephalopa | 1994 |
Vegetable versus animal protein diet in cirrhotic patients with chronic encephalopathy. A randomized cross-over comparison.
Topics: Aged; Amino Acids; Ammonia; Blood Glucose; Chronic Disease; Dietary Proteins; Hepatic Encephalopathy | 1993 |
Helicobacter pylori is a risk factor for hepatic encephalopathy in acute alcoholic hepatitis: the ammonia hypothesis revisited. The Veterans Administration Cooperative Study Group No. 275.
Topics: Ammonia; Cohort Studies; Helicobacter Infections; Helicobacter pylori; Hepatic Encephalopathy; Hepat | 1993 |
Long-term effects of Enterococcus faecium SF68 versus lactulose in the treatment of patients with cirrhosis and grade 1-2 hepatic encephalopathy.
Topics: Adult; Aged; Ammonia; Dose-Response Relationship, Drug; Double-Blind Method; Enterococcus faecium; E | 1995 |
Therapeutic efficacy of L-ornithine-L-aspartate infusions in patients with cirrhosis and hepatic encephalopathy: results of a placebo-controlled, double-blind study.
Topics: Adult; Aged; Ammonia; Dipeptides; Double-Blind Method; Female; Hepatic Encephalopathy; Humans; Infus | 1997 |
Therapeutic efficacy of L-ornithine-L-aspartate infusions in patients with cirrhosis and hepatic encephalopathy: results of a placebo-controlled, double-blind study.
Topics: Adult; Aged; Ammonia; Dipeptides; Double-Blind Method; Female; Hepatic Encephalopathy; Humans; Infus | 1997 |
Therapeutic efficacy of L-ornithine-L-aspartate infusions in patients with cirrhosis and hepatic encephalopathy: results of a placebo-controlled, double-blind study.
Topics: Adult; Aged; Ammonia; Dipeptides; Double-Blind Method; Female; Hepatic Encephalopathy; Humans; Infus | 1997 |
Therapeutic efficacy of L-ornithine-L-aspartate infusions in patients with cirrhosis and hepatic encephalopathy: results of a placebo-controlled, double-blind study.
Topics: Adult; Aged; Ammonia; Dipeptides; Double-Blind Method; Female; Hepatic Encephalopathy; Humans; Infus | 1997 |
Magnetic resonance spectroscopy in the study of hyperammonemia and hepatic encephalopathy.
Topics: Ammonia; Double-Blind Method; Hepatic Encephalopathy; Humans; Liver Diseases; Magnetic Resonance Spe | 1997 |
Rifaximin, a non-absorbable rifamycin, for the treatment of hepatic encephalopathy. A double-blind, randomised trial.
Topics: Administration, Oral; Adult; Aged; Ammonia; Anti-Bacterial Agents; Double-Blind Method; Female; Hepa | 1997 |
Clinical efficacy of lactulose in cirrhotic patients with and without subclinical hepatic encephalopathy.
Topics: Administration, Oral; Adult; Aged; Ammonia; Cathartics; Female; Hepatic Encephalopathy; Humans; Lact | 1997 |
Oral L-ornithine-L-aspartate therapy of chronic hepatic encephalopathy: results of a placebo-controlled double-blind study.
Topics: Administration, Oral; Adult; Ammonia; Dietary Proteins; Dipeptides; Double-Blind Method; Female; Hep | 1998 |
Oral L-ornithine-L-aspartate therapy of chronic hepatic encephalopathy: results of a placebo-controlled double-blind study.
Topics: Administration, Oral; Adult; Ammonia; Dietary Proteins; Dipeptides; Double-Blind Method; Female; Hep | 1998 |
Oral L-ornithine-L-aspartate therapy of chronic hepatic encephalopathy: results of a placebo-controlled double-blind study.
Topics: Administration, Oral; Adult; Ammonia; Dietary Proteins; Dipeptides; Double-Blind Method; Female; Hep | 1998 |
Oral L-ornithine-L-aspartate therapy of chronic hepatic encephalopathy: results of a placebo-controlled double-blind study.
Topics: Administration, Oral; Adult; Ammonia; Dietary Proteins; Dipeptides; Double-Blind Method; Female; Hep | 1998 |
Results of a phase I trial evaluating a liver support device utilizing albumin dialysis.
Topics: Adolescent; Adult; Ammonia; Bilirubin; Blood Coagulation; Hemodiafiltration; Hepatic Encephalopathy; | 2001 |
Comparison of lactulose and neomycin in the treatment of chronic portal-systemic encephalopathy. A double blind controlled trial.
Topics: Aged; Ammonia; Blood; Chronic Disease; Clinical Trials as Topic; Disaccharides; Electroencephalograp | 1977 |
[Anti-ammonemic activity of the gamma-ethyl ester of glutamic acid. Controlled clinical study].
Topics: Ammonia; Blood Gas Analysis; Clinical Trials as Topic; Drug Evaluation; Glutamates; Hepatic Encephal | 1979 |
Treatment of chronic portal systemic encephalopathy with bromocriptine: a double-blind controlled trial.
Topics: Ammonia; Bromocriptine; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Electroencep | 1979 |
[Medical treatment of hyperammoniemia in the elderly. Controlled clinical study].
Topics: Aged; Ammonia; Arginine; Double-Blind Method; Drug Evaluation; Female; Glutamates; Hepatic Encephalo | 1979 |
[Changes in the levels of ammonia and free phenols in patients with portocaval shunt treated with lactulose and/or neomycin compared to a low protein diet (author's transl)].
Topics: Ammonia; Dietary Proteins; Disaccharides; Drug Therapy, Combination; Hepatic Encephalopathy; Humans; | 1978 |
Reduction of gastric ammonia by ampicillin in normal and azotemic subjects.
Topics: Ammonia; Ampicillin; Betazole; Gastric Juice; Hepatic Encephalopathy; Humans; Neomycin; Uremia | 1976 |
Intensive enteral feeding in advanced cirrhosis: reversal of malnutrition without precipitation of hepatic encephalopathy.
Topics: Amino Acids; Ammonia; Anthropometry; Child; Child, Preschool; Enteral Nutrition; Female; Hepatic Enc | 1992 |
Rifaximin versus neomycin on hyperammoniemia in chronic portal systemic encephalopathy of cirrhotics. A double-blind, randomized trial.
Topics: Aged; Ammonia; Chronic Disease; Double-Blind Method; Female; Hepatic Encephalopathy; Humans; Liver C | 1991 |
Successful use of vancomycin hydrochloride in the treatment of lactulose resistant chronic hepatic encephalopathy.
Topics: Ammonia; Bacteria; Disaccharides; Double-Blind Method; Drug Resistance; Electroencephalography; Fece | 1990 |
[Amino acids prevent hepatic encephalopathy. Ornithine-aspartate in hyperammonemia--results of a study].
Topics: Ammonia; Aspartic Acid; Clinical Trials as Topic; Double-Blind Method; Hepatic Encephalopathy; Human | 1989 |
Venous, arterial, and arterialized-venous blood ammonia levels and their relationship to hepatic encephalopathy after propranolol.
Topics: Ammonia; Arteries; Hepatic Encephalopathy; Humans; Hypertension, Portal; Liver Cirrhosis; Male; Prop | 1988 |
[Branched-chain amino acids in the treatment of latent porto-systemic encephalopathy. A placebo-controlled double-blind cross-over study].
Topics: Administration, Oral; Adult; Aged; Amino Acids, Branched-Chain; Ammonia; Caseins; Clinical Trials as | 1986 |
A new therapy for portal systemic encephalopathy.
Topics: Aged; Ammonia; Benzoates; Benzoic Acid; Double-Blind Method; Drug Evaluation; Hepatic Encephalopathy | 1986 |
Treatment of acute hepatic encephalopathy in cirrhotics with a branched-chain amino acids enriched versus a conventional amino acids mixture. A controlled study of 70 patients.
Topics: Acute Disease; Adult; Aged; Amino Acids; Amino Acids, Branched-Chain; Ammonia; Electroencephalograph | 1985 |
[Acute liver failure].
Topics: Acute Disease; Adrenal Cortex Hormones; Ammonia; Biopsy, Needle; Blood Coagulation Disorders; Blood | 1974 |
Lactulose in the treatment of chronic portal-systemic encephalopathy. A double-blind clinical trial.
Topics: Adult; Aged; Alcoholism; Ammonia; Brain Diseases; Chronic Disease; Clinical Trials as Topic; Colon; | 1969 |
[On the therapy of liver diseases with ornithine aspartate].
Topics: Acute Disease; Alanine Transaminase; Ammonia; Aspartic Acid; Bilirubin; Cholangitis; Chronic Disease | 1969 |
998 other studies available for ammonium hydroxide and Hepatic Encephalopathy
| Article | Year |
|---|---|
The improvement in body composition including subcutaneous and visceral fat reduces ammonia and hepatic encephalopathy after transjugular intrahepatic portosystemic shunt.
Topics: Ammonia; Body Composition; Hepatic Encephalopathy; Humans; Intra-Abdominal Fat; Liver Cirrhosis; Por | 2021 |
Prediction of minimal hepatic encephalopathy by using an radiomics nomogram in chronic hepatic schistosomiasis patients.
Topics: Aged; Ammonia; Female; Hepatic Encephalopathy; Humans; Magnetic Resonance Imaging; Male; Middle Aged | 2021 |
Population Pharmacokinetic Analysis to Assist Dose Selection of the L-Ornithine Salt of Phenylacetic Acid.
Topics: Adult; Ammonia; Clinical Trials as Topic; Hepatic Encephalopathy; Humans; Ornithine; Phenylacetates | 2022 |
Saul Brusilow: Understanding and treating diseases of ammonia toxicity.
Topics: Ammonia; Animals; Hepatic Encephalopathy; History, 20th Century; History, 21st Century; Humans; Hype | 2022 |
Syringic acid protects against thioacetamide-induced hepatic encephalopathy: Behavioral, biochemical, and molecular evidence.
Topics: Ammonia; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Cytokines; Gallic Acid; Hepatic | 2022 |
The rise and fall and rise again of ammonia as a therapeutic target in HE.
Topics: Ammonia; Hepatic Encephalopathy; Humans | 2022 |
Molecular mechanisms involved in the effects of morin in experimental hepatic encephalopathy.
Topics: Alanine Transaminase; Ammonia; Animals; Antioxidants; Aspartate Aminotransferases; Flavones; Flavono | 2022 |
Distinct responsiveness to rifaximin in patients with hepatic encephalopathy depends on functional gut microbial species.
Topics: Ammonia; Animals; Bacteria; Bile Acids and Salts; Gastrointestinal Microbiome; Hepatic Encephalopath | 2022 |
Low cerebral energy metabolism in hepatic encephalopathy reflects low neuronal energy demand. Role of ammonia-induced increased GABAergic tone.
Topics: Ammonia; Brain; Energy Metabolism; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Neuron | 2022 |
Sex is associated with differences in oxidative stress and susceptibility to severe hepatic encephalopathy in bile-duct ligated rats.
Topics: Allopurinol; Ammonia; Animals; Bile; Disease Models, Animal; Female; Hepatic Encephalopathy; Hyperam | 2022 |
Effects of PCSK-9 Inhibition by Alirocumab Treatments on Biliary Cirrhotic Rats.
Topics: Ammonia; Animals; Antibodies, Monoclonal, Humanized; Cholesterol, LDL; Fibrosis; Hepatic Encephalopa | 2022 |
Metabolic changes of the reduction of manganese intake in the hepatic encephalopathy rat: NMR- and MS-based metabolomics study.
Topics: Amino Acids; Ammonia; Animals; gamma-Aminobutyric Acid; Glutamate-Ammonia Ligase; Hepatic Encephalop | 2022 |
Plasma ammonia levels predict hospitalisation with liver-related complications and mortality in clinically stable outpatients with cirrhosis.
Topics: Ammonia; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Hepatic Encephalopathy; Hospit | 2022 |
SB332235, a CXCR2 antagonist, ameliorates thioacetamide-induced hepatic encephalopathy through modulation of the PI3K/AKT pathways in rats.
Topics: Albumins; Ammonia; Animals; Anti-Inflammatory Agents; Antioxidants; Bilirubin; Caspase 3; Hepatic En | 2022 |
The Ongoing Debate of Serum Ammonia Levels in Cirrhosis: the Good, the Bad, and the Ugly.
Topics: Ammonia; Gastroenterology; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Liver Function Tests | 2023 |
Add-on Therapeutic Effects of Rifaximin on Treatment-resistant Hepatic Encephalopathy.
Topics: Ammonia; Gastrointestinal Agents; Hepatic Encephalopathy; Humans; Lactulose; Liver Cirrhosis; Rifamy | 2023 |
Inhibition of Autotaxin Ameliorates LPA-Mediated Neuroinflammation and Alleviates Neurological Dysfunction in Acute Hepatic Encephalopathy.
Topics: Alanine Transaminase; Ammonia; Animals; Aspartate Aminotransferases; Bilirubin; Brain Diseases; Hepa | 2022 |
Clinical findings of patients with hyperammonemia affected by urea cycle disorders with hepatic encephalopathy.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Hyperammonemia; Ornithine Carbamoyltransferase Deficiency D | 2022 |
Long-Term Effects of Rifaximin on Patients with Hepatic Encephalopathy: Its Possible Effects on the Improvement in the Blood Ammonia Concentration Levels, Hepatic Spare Ability and Refractory Ascites.
Topics: Ammonia; Ascites; Diuretics; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Quality of Life; Renin | 2022 |
Ammonia and prognosis of cirrhosis: A new perspective for identifying high-risk patients.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Prognosis | 2023 |
Ameliorative Effect of Chitosan Oligosaccharides on Hepatic Encephalopathy by Reshaping Gut Microbiota and Gut-Liver Axis.
Topics: Ammonia; Animals; Chitosan; DNA, Ribosomal; Gastrointestinal Microbiome; Hepatic Encephalopathy; Oli | 2022 |
A mouse model of hepatic encephalopathy: bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation.
Topics: Ammonia; Animals; Bile Acids and Salts; Bile Ducts; Brain; Choline; Disease Models, Animal; Glutamin | 2022 |
Hypokalaemia - an active contributor to hepatic encephalopathy?
Topics: Ammonia; Hepatic Encephalopathy; Humans; Hyperammonemia; Hypokalemia; Liver Cirrhosis; Potassium | 2023 |
Reply to: "Ammonia and prognosis of cirrhosis: A new perspective for identifying high risk patients".
Topics: Ammonia; Fibrosis; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Prognosis | 2023 |
Rifaximin stimulates nitrogen detoxification by PXR-independent mechanisms in human small intestinal organoids.
Topics: Amino Acids; Ammonia; Hepatic Encephalopathy; Humans; Pregnane X Receptor; Receptors, Steroid; Rifam | 2023 |
Rifaximin stimulates nitrogen detoxification by PXR-independent mechanisms in human small intestinal organoids.
Topics: Amino Acids; Ammonia; Hepatic Encephalopathy; Humans; Pregnane X Receptor; Receptors, Steroid; Rifam | 2023 |
Rifaximin stimulates nitrogen detoxification by PXR-independent mechanisms in human small intestinal organoids.
Topics: Amino Acids; Ammonia; Hepatic Encephalopathy; Humans; Pregnane X Receptor; Receptors, Steroid; Rifam | 2023 |
Rifaximin stimulates nitrogen detoxification by PXR-independent mechanisms in human small intestinal organoids.
Topics: Amino Acids; Ammonia; Hepatic Encephalopathy; Humans; Pregnane X Receptor; Receptors, Steroid; Rifam | 2023 |
Changes of Plasma Blood Ammonia Levels of Chinese Healthy People and the Establishment of Reference Intervals.
Topics: Ammonia; China; East Asian People; Female; Health Status; Hematologic Tests; Hepatic Encephalopathy; | 2023 |
J-difference GABA-edited MRS reveals altered cerebello-thalamo-cortical metabolism in patients with hepatic encephalopathy.
Topics: Ammonia; Cerebellum; Choline; gamma-Aminobutyric Acid; Glutamine; Hepatic Encephalopathy; Humans; In | 2023 |
[A Case of Perihilar Cholangiocarcinoma with Postoperative Hepatic Encephalopathy Due to Portosystemic Shunt Treated by Percutaneous Embolization].
Topics: Aged, 80 and over; Ammonia; Bile Duct Neoplasms; Female; Hepatic Encephalopathy; Humans; Klatskin Tu | 2023 |
Serum ammonia does not guide management and is overutilised in patients with cirrhosis in hospital settings.
Topics: Ammonia; Australia; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Retrospective Studies; Tertiary | 2023 |
Prevalence of Minimal Hepatic Encephalopathy in Patients With Liver Cirrhosis: A Multicenter Study.
Topics: Ammonia; End Stage Liver Disease; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Prevalence; Psych | 2023 |
Hyperammonemia induces microglial NLRP3 inflammasome activation via mitochondrial oxidative stress in hepatic encephalopathy.
Topics: Ammonia; Animals; Hepatic Encephalopathy; Hyperammonemia; Inflammasomes; Lipopolysaccharides; Mice; | 2023 |
Severe Acute Liver Dysfunction Induces Delayed Hepatocyte Swelling and Cytoplasmic Vacuolization, and Delayed Cortical Neuronal Cell Death.
Topics: Ammonia; Animals; Astrocytes; Brain Edema; Edema; Hepatic Encephalopathy; Hepatocytes; Mice | 2023 |
Indole-3-carbinol ameliorated the thioacetamide-induced hepatic encephalopathy in rats.
Topics: Ammonia; Animals; Cytochrome P-450 CYP2E1; Cytokines; Hepatic Encephalopathy; Liver; Oxidative Stres | 2023 |
Special Issue: Pathophysiology, diagnosis, and management of hepatic encephalopathy.
Topics: Ammonia; Hepatic Encephalopathy; Humans | 2023 |
Ammonia - an enduring foe - What evaluating whole body ammonia metabolism can teach us about cirrhosis and therapies treating hepatic encephalopathy.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Lactulose; Liver Cirrhosis; Rifamycins; Rifaximin | 2023 |
Lactoferrin averts neurological and behavioral impairments of thioacetamide-induced hepatic encephalopathy in rats via modulating HGMB1/TLR-4/MyD88/Nrf2 pathway.
Topics: Ammonia; Animals; Hepatic Encephalopathy; HMGB1 Protein; Lactoferrin; Liver; Myeloid Differentiation | 2023 |
Influence of NOD2 risk variants on hepatic encephalopathy and association with inflammation, bacterial translocation and immune activation.
Topics: Ammonia; Bacterial Translocation; Female; Hepatic Encephalopathy; Humans; Inflammation; Lipopolysacc | 2023 |
Simultaneous use of plug-assisted and coil-assisted retrograde transvenous obliteration for treating refractory hepatic encephalopathy in a patient with two portosystemic shunts: A case report.
Topics: Ammonia; Balloon Occlusion; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Hepatic Enc | 2023 |
Development and validation of the AMMON-OHE model to predict risk of overt hepatic encephalopathy occurrence in outpatients with cirrhosis.
Topics: Ammonia; Creatinine; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Outpatients; Prospective Studi | 2023 |
The pathogenesis of gut microbiota in hepatic encephalopathy by the gut-liver-brain axis.
Topics: Ammonia; Brain; Fibrosis; Gastrointestinal Microbiome; Hepatic Encephalopathy; Humans; Hyperammonemi | 2023 |
Measuring and Interpreting Ammonia Levels in Cirrhosis.
Topics: Ammonia; Fibrosis; Hepatic Encephalopathy; Humans; Liver Cirrhosis | 2023 |
Hyperammonemia induced gut microbiota dysbiosis and motor coordination disturbances in mice: new insight into gut‑brain axis involvement in hepatic encephalopathy.
Topics: Ammonia; Animals; Brain-Gut Axis; Dysbiosis; Gastrointestinal Microbiome; Hepatic Encephalopathy; Hy | 2023 |
Ammonia predicts clinical outcomes in cirrhosis - but there are caveats to consider.
Topics: Ammonia; Fibrosis; Hepatic Encephalopathy; Humans; Liver Cirrhosis | 2023 |
The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study.
Topics: Alanine; Ammonia; Animals; Arginine; Brain; Citrulline; gamma-Aminobutyric Acid; Glutamic Acid; Glut | 2023 |
Reply to: "Ammonia predicts clinical outcomes in cirrhosis - but there are caveats to consider".
Topics: Ammonia; Fibrosis; Hepatic Encephalopathy; Humans; Liver Cirrhosis | 2023 |
Impaired Enzymatic Antioxidant Defense in Erythrocytes of Rats with Ammonia-Induced Encephalopathy: Role of NMDA Receptors.
Topics: Ammonia; Animals; Antioxidants; Dizocilpine Maleate; Erythrocytes; Hepatic Encephalopathy; Humans; H | 2023 |
[Embolization of spontaneous portosystemic shunts as treatment for refractory hepatic encephalopathy].
Topics: Ammonia; Female; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Male; Portasystemic Shunt, Transju | 2022 |
Variability and Lability of Ammonia Levels in Healthy Volunteers and Patients With Cirrhosis: Implications for Trial Design and Clinical Practice.
Topics: Adolescent; Adult; Aged; Ammonia; Biomarkers; Clinical Trials as Topic; Disease Progression; Female; | 2020 |
Predictive value of induced hyperammonaemia and neuropsychiatric profiling in relation to the occurrence of post-TIPS hepatic encephalopathy.
Topics: Aged; Amino Acids; Ammonia; Female; Hepatic Encephalopathy; Humans; Hyperammonemia; Liver Cirrhosis; | 2019 |
Characterization of Oxidative Stress and Ammonia According to the Different Grades of Hepatic Encephalopathy.
Topics: Adult; Aged; Ammonia; Animals; Biomarkers; Chronic Disease; Cross-Sectional Studies; Female; Healthy | 2020 |
BabaoDan cures hepatic encephalopathy by decreasing ammonia levels and alleviating inflammation in rats.
Topics: Ammonia; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Hepatic Encephalopathy; Inflamma | 2020 |
Comparative accuracy and precision of two commercial laboratory analyzers for the quantification of ammonia in cerebrospinal fluid.
Topics: Ammonia; Animals; Blood Chemical Analysis; Hepatic Encephalopathy; Horse Diseases; Horses; Hyperammo | 2020 |
Minimal Hepatic Encephalopathy is Associated with Increased Cerebral Vascular Resistance. A Transcranial Doppler Ultrasound Study.
Topics: Aged; Ammonia; Case-Control Studies; Cerebral Arteries; Endothelial Cells; Female; Hemodynamics; Hep | 2019 |
Ammonia Levels Do Not Guide Clinical Management of Patients With Hepatic Encephalopathy Caused by Cirrhosis.
Topics: Ammonia; Biomarkers; Disease Management; Female; Follow-Up Studies; Gastrointestinal Agents; Hepatic | 2020 |
Low-Value Levels: Ammonia Testing Does Not Improve the Outcomes of Overt Hepatic Encephalopathy.
Topics: Ammonia; Healthy Volunteers; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Liver Function Tests | 2020 |
Oral glutamine challenge is a marker of altered ammonia metabolism and predicts the risk of hepatic encephalopathy.
Topics: Administration, Oral; Ammonia; Glutamine; Hepatic Encephalopathy; Humans; Liver Cirrhosis | 2020 |
KASL clinical practice guidelines for liver cirrhosis: Varices, hepatic encephalopathy, and related complications.
Topics: Adrenergic beta-Antagonists; Ammonia; Anti-Bacterial Agents; Carvedilol; Disaccharides; Endoscopy, G | 2020 |
Ammonia uptake by transmembrane pH gradient poly(isoprene)-block-poly(ethylene glycol) polymersomes.
Topics: Ammonia; Butadienes; Drug Carriers; Fluorescein-5-isothiocyanate; Hemiterpenes; Hepatic Encephalopat | 2020 |
Aberrant brain structural network and altered topological organization in minimal hepatic encephalopathy.
Topics: Aged; Ammonia; Brain; Brain Mapping; Case-Control Studies; Diffusion Tensor Imaging; Female; Hepatic | 2020 |
A bioartificial liver support system integrated with a DLM/GelMA-based bioengineered whole liver for prevention of hepatic encephalopathy via enhanced ammonia reduction.
Topics: Ammonia; Animals; Extracellular Matrix; Gelatin; Hepatic Encephalopathy; Hepatocytes; Liver, Artific | 2020 |
Spastic paraparesis associated with advanced liver cirrhosis: a condition obscure in terms of treatment and prognosis.
Topics: Adult; Ammonia; Diagnosis, Differential; Disease Progression; Hepatic Encephalopathy; Humans; Liver | 2020 |
Important Unresolved Questions in the Management of Hepatic Encephalopathy: An ISHEN Consensus.
Topics: Ammonia; Automobile Driving; Hepatic Encephalopathy; Humans; Nutritional Support; Patient Reported O | 2020 |
Synergistic effect of aminoguanidine and l-carnosine against thioacetamide-induced hepatic encephalopathy in rats: behavioral, biochemical, and ultrastructural evidence.
Topics: Ammonia; Animals; Behavior, Animal; Brain; Brain Chemistry; Carnosine; Drug Synergism; Guanidines; H | 2021 |
L-carnitine reduces hospital admissions in patients with hepatic encephalopathy.
Topics: Ammonia; Carnitine; Hepatic Encephalopathy; Hospitals; Humans; Liver Cirrhosis | 2021 |
Changes in the Body Composition and Nutritional Status after Long-term Rifaximin Therapy for Hyperammonemia in Japanese Patients with Hepatic Encephalopathy.
Topics: Aged; Ammonia; Bilirubin; Body Composition; Carcinoma, Hepatocellular; Female; Hepatic Encephalopath | 2020 |
A Trial of Ornithine Phenylacetate and the Arc of Ammonia's History in the Management of Overt Hepatic Encephalopathy.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Ornithine | 2021 |
Bile-duct ligation renders the brain susceptible to hypotension-induced neuronal degeneration: Implications of ammonia.
Topics: Ammonia; Animals; Antigens, Nuclear; Anxiety; Apoptosis; Behavior, Animal; Bile Ducts; Caspase 3; Ce | 2021 |
A Prospective, Blinded Assessment of Ammonia Testing Demonstrates Low Utility Among Front-Line Clinicians.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Prospective Studies | 2022 |
Sirtuin-3 activation by honokiol restores mitochondrial dysfunction in the hippocampus of the hepatic encephalopathy rat model of ammonia neurotoxicity.
Topics: Ammonia; Animals; Disease Models, Animal; Hepatic Encephalopathy; Hippocampus; Male; Mitochondria; N | 2021 |
Erroneous Ammonia Measurement is Not Synonymous With a Lack of Efficacy of Ammonia-Lowering Therapies in Hepatic Encephalopathy.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis | 2021 |
Reply.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Ornithine | 2021 |
[Alkalosis, albumin, ammonia and hepatic encephalopathy].
Topics: Albumins; Alkalosis; Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis | 2021 |
Elevation of Autoantibodies to Cerebral Proteins in Hepatic Encephalopathy: Another Pathogenic Factor?
Topics: Ammonia; Animals; Autoantibodies; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Rats; Virulence F | 2022 |
Hyperammonemia in acetaminophen toxicity.
Topics: Acetaminophen; Ammonia; Animals; Hepatic Encephalopathy; Humans; Hyperammonemia; Retrospective Studi | 2022 |
Alkalemia and Hepatic Encephalopathy in a Chronic Dialysis Patient.
Topics: Acid-Base Equilibrium; Aged; Ammonia; Hepatic Encephalopathy; Humans; Kidney Failure, Chronic; Liver | 2021 |
Surgical Debulking for Refractory Hyperammonemic Encephalopathy in Fibrolamellar Hepatocellular Carcinoma.
Topics: Adult; Ammonia; Carcinoma, Hepatocellular; Cytoreduction Surgical Procedures; Hepatic Encephalopathy | 2021 |
Dexmedetomidine alleviates neuroinflammation, restores sleep disorders and neurobehavioral abnormalities in rats with minimal hepatic encephalopathy.
Topics: Adrenergic alpha-2 Receptor Agonists; Ammonia; Animals; Anti-Inflammatory Agents; Anxiety; Behavior, | 2021 |
Dynamic assessments of hepatic encephalopathy and ammonia levels predict mortality in acute-on-chronic liver failure.
Topics: Acute-On-Chronic Liver Failure; Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Prognosis; | 2021 |
Can Patients Who Develop Cerebral Death in Fulminant Liver Failure Despite Liver Transplantation Be Previously Forseen?
Topics: Adolescent; Adult; Aged; Ammonia; Bilirubin; Biomarkers; Brain Death; Case-Control Studies; Child; C | 2017 |
Oral administration of trace element magnesium significantly improving the cognition and locomotion in hepatic encephalopathy rats.
Topics: Administration, Oral; Ammonia; Animals; Brain; Cognition; Dietary Supplements; Disease Models, Anima | 2017 |
Ameliorative effects of rutin on hepatic encephalopathy-induced by thioacetamide or gamma irradiation.
Topics: Acetylcholinesterase; Administration, Oral; Alanine Transaminase; Ammonia; Animals; Aspartate Aminot | 2017 |
Time-dependent negative bias in plasma ammonia samples in a clinical setting.
Topics: Ammonia; Bias; Blood Chemical Analysis; Hepatic Encephalopathy; Humans; Metabolism, Inborn Errors; T | 2017 |
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Proton Pump Inhibitors; Research Design | 2017 |
Ammonia Levels and Hepatic Encephalopathy in Patients with Known Chronic Liver Disease.
Topics: Ammonia; Disease Progression; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Male; Middle Aged | 2017 |
Refractory hepatic encephalopathy in a patient with hypothyroidism: Another element in ammonia metabolism.
Topics: Adrenergic beta-Antagonists; Alcoholism; Ammonia; Antithyroid Agents; Brain; Carbimazole; Diagnosis, | 2017 |
Ammonia concentrations in arterial blood, venous blood, and cerebrospinal fluid of dogs with and without congenital extrahepatic portosystemic shunts.
Topics: Ammonia; Animals; Arteries; Blood-Brain Barrier; Dog Diseases; Dogs; Female; Hepatic Encephalopathy; | 2017 |
Fecal microbiota transplantation prevents hepatic encephalopathy in rats with carbon tetrachloride-induced acute hepatic dysfunction.
Topics: Ammonia; Animals; Carbon Tetrachloride Poisoning; Fecal Microbiota Transplantation; Hepatic Encephal | 2017 |
Should venous ammonia be used in decision-making acute liver failure patients?
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver Failure, Acute; Renal Replacement Therapy | 2018 |
Treating hepatic encephalopathy in cirrhotic patients admitted to ICU with sodium phenylbutyrate: a preliminary study.
Topics: Aged; Ammonia; Biomarkers; Case-Control Studies; Female; Hepatic Encephalopathy; Hospital Mortality; | 2018 |
Brain MRI findings in acute hepatic encephalopathy in liver transplant recipients.
Topics: Adult; Ammonia; Brain; Cohort Studies; Female; Hepatic Encephalopathy; Humans; Image Processing, Com | 2018 |
Rifaximin ameliorates hepatic encephalopathy and endotoxemia without affecting the gut microbiome diversity.
Topics: Aged; Aged, 80 and over; Ammonia; Anti-Bacterial Agents; Case-Control Studies; Cognition; Endotoxemi | 2017 |
Stroop Test Validation to Screen for Minimal Hepatic Encephalopathy in Pediatric Extrahepatic Portal Venous Obstruction.
Topics: Ammonia; Child; Cross-Sectional Studies; Female; Hepatic Encephalopathy; Humans; Hypertension, Porta | 2018 |
Assessment of the spectrum of hepatic encephalopathy: A multicenter study.
Topics: Ammonia; Biomarkers; Canada; Clinical Competence; Cognition; Diet, Protein-Restricted; Education, Me | 2018 |
Metformin modifies glutamine metabolism in an in vitro and in vivo model of hepatic encephalopathy.
Topics: Ammonia; Animals; Caco-2 Cells; Child, Preschool; Glutaminase; Glutamine; Hepatic Encephalopathy; Hu | 2018 |
Medium-chain triglycerides supplement therapy with a low-carbohydrate formula can supply energy and enhance ammonia detoxification in the hepatocytes of patients with adult-onset type II citrullinemia.
Topics: Aged; Ammonia; Argininosuccinate Synthase; Carbohydrates; Citrullinemia; Dietary Supplements; Fatty | 2018 |
Myosteatosis and sarcopenia are associated with hepatic encephalopathy in patients with cirrhosis.
Topics: Adipose Tissue; Age Factors; Aged; Ammonia; Canada; Correlation of Data; Female; Hepatic Encephalopa | 2018 |
Efficacy of different drugs in the treatment of minimal hepatic encephalopathy: A network meta-analysis involving 826 patients based on 10 randomized controlled trials.
Topics: Acetylcarnitine; Adult; Ammonia; Dipeptides; Female; Hepatic Encephalopathy; Humans; Lactulose; Male | 2018 |
Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure.
Topics: Ammonia; Animals; Bile Acids and Salts; Cell Line; Disease Models, Animal; End Stage Liver Disease; | 2018 |
Aloin Inhibits Müller Cells Swelling in a Rat Model of Thioacetamide-Induced Hepatic Retinopathy.
Topics: Ammonia; Animals; Aquaporin 4; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Emodi | 2018 |
L-Carnitine for the Treatment of Overt Hepatic Encephalopathy in Patients with Advanced Liver Cirrhosis.
Topics: Aged; Aged, 80 and over; Ammonia; Carnitine; Female; Hepatic Encephalopathy; Humans; Liver Cirrhosis | 2018 |
Progressive resistance training prevents loss of muscle mass and strength in bile duct-ligated rats.
Topics: Ammonia; Animals; Bile Ducts; Body Composition; Disease Models, Animal; Hepatic Encephalopathy; Hype | 2019 |
The modification of quantity and quality of muscle mass improves the cognitive impairment after TIPS.
Topics: Ammonia; Cognitive Dysfunction; Female; Hepatic Encephalopathy; Humans; Italy; Liver Cirrhosis; Male | 2019 |
Prognostic significance of minimal hepatic encephalopathy in patients with liver cirrhosis in Japan: A propensity score-matching analysis.
Topics: Adolescent; Adult; Aged; Ammonia; Biomarkers; Carcinoma, Hepatocellular; Female; Hepatic Encephalopa | 2019 |
Altered cognitive control network is related to psychometric and biochemical profiles in covert hepatic encephalopathy.
Topics: Aged; Ammonia; Brain; Brain Mapping; Cognition; Executive Function; Female; Gyrus Cinguli; Hepatic E | 2019 |
Letter to Editor: Prognostic Role of Ammonia in Patients With Cirrhosis.
Topics: Ammonia; Fibrosis; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Prognosis | 2019 |
Possibilities of therapeutic correction of hyperammonemia and minimal hepatic encephalopathy in patients with chronic hepatitis C at the pre-cirrhotic stage.
Topics: Adult; Ammonia; Case-Control Studies; Dipeptides; Hepatic Encephalopathy; Hepatitis C, Chronic; Huma | 2019 |
Acute hyperammonemic encephalopathy due to a portosystemic shunt in a non-cirrhotic adult patient.
Topics: Aged; Ammonia; Diagnosis, Differential; Embolization, Therapeutic; Hepatic Encephalopathy; Humans; H | 2019 |
Hepatic encephalopathy: an enigma from patient to enzyme and back.
Topics: Ammonia; Animals; Hepatic Encephalopathy; Humans; Hyperammonemia; Nitrogen | 2013 |
Hepatic encephalopathy is related to anemia and fat-free mass depletion in liver transplant candidates with cirrhosis.
Topics: Absorptiometry, Photon; Adult; Ammonia; Anemia; Body Mass Index; Cytokines; Female; Glomerular Filtr | 2013 |
Rifaximin is an efficacious treatment for the Parkinsonian phenotype of hepatic encephalopathy.
Topics: Aged; Ammonia; Anti-Infective Agents; Brain; Electroencephalography; Female; Hepatic Encephalopathy; | 2013 |
Osmotic and oxidative/nitrosative stress in ammonia toxicity and hepatic encephalopathy.
Topics: Ammonia; Animals; Astrocytes; Brain; Brain Edema; Gene Expression Regulation; Hepatic Encephalopathy | 2013 |
Hepatic encephalopathy: clinical aspects and pathogenetic concept.
Topics: Ammonia; Brain; Hepatic Encephalopathy; Humans; Liver | 2013 |
Precipitants of hepatic encephalopathy induce rapid astrocyte swelling in an oxidative stress dependent manner.
Topics: Ammonia; Animals; Astrocytes; Brain; Cell Nucleus; Cell Size; Cells, Cultured; Diazepam; Hepatic Enc | 2013 |
Hydrogen: a promising novel treatment for hepatic encephalopathy?
Topics: Ammonia; Hepatic Encephalopathy; Humans; Hydrogen; Liver Diseases | 2013 |
[Analysis of L-asparaginase induced elevation of blood ammonia and hepatic encephalopathy].
Topics: Adolescent; Adult; Aged; Ammonia; Asparaginase; Female; Hepatic Encephalopathy; Humans; Male; Middle | 2013 |
Lipopolysaccharide precipitates hepatic encephalopathy and increases blood-brain barrier permeability in mice with acute liver failure.
Topics: Ammonia; Animals; Azoxymethane; Blood-Brain Barrier; Cytokines; Disease Models, Animal; Hepatic Ence | 2014 |
Oral glutamine challenge improves the performance of psychometric tests for the diagnosis of minimal hepatic encephalopathy in patients with liver cirrhosis.
Topics: Administration, Oral; Adult; Ammonia; Area Under Curve; Biomarkers; Case-Control Studies; Female; Gl | 2013 |
Drug-induced removal of nitrogen derivatives in urine: a new concept whose time has come.
Topics: Ammonia; Female; Glycerol; Hepatic Encephalopathy; Humans; Hyperammonemia; Male; Phenylbutyrates | 2014 |
Increased toll-like receptor 4 in cerebral endothelial cells contributes to the astrocyte swelling and brain edema in acute hepatic encephalopathy.
Topics: Acute Disease; Ammonia; Animals; Astrocytes; Brain Edema; Cell Communication; Cells, Cultured; Cereb | 2014 |
Effect of glutamine synthetase inhibition on brain and interorgan ammonia metabolism in bile duct ligated rats.
Topics: Amino Acids; Ammonia; Animals; Brain; Female; Glutamate-Ammonia Ligase; Hepatic Encephalopathy; Kidn | 2014 |
Effect of molecular adsorbents recirculating system treatment in children with acute liver failure caused by Wilson disease.
Topics: Acute Kidney Injury; Adolescent; Adsorption; Albumins; Ammonia; Bilirubin; Child; Copper; Creatinine | 2014 |
Increased brain lactate is central to the development of brain edema in rats with chronic liver disease.
Topics: Ammonia; Animals; Brain; Brain Edema; Chronic Disease; Glutamine; Hepatic Encephalopathy; Lactic Aci | 2014 |
Relationships between splenorenal shunt/portal vein diameter ratio and systemic hemodynamics in patients with liver cirrhosis.
Topics: Adult; Aged; Aged, 80 and over; Ammonia; Esophageal and Gastric Varices; Female; Hepatic Encephalopa | 2014 |
Ammonia levels and the severity of hepatic encephalopathy.
Topics: Adult; Ammonia; Female; Hepatic Encephalopathy; Humans; Hyperammonemia; Liver Cirrhosis; Male; Middl | 2014 |
Pannexin1 as a novel cerebral target in pathogenesis of hepatic encephalopathy.
Topics: Ammonia; Brain; Connexins; Energy Metabolism; Glutamic Acid; Heart Arrest; Hepatic Encephalopathy; H | 2014 |
Decreased astrocytic thrombospondin-1 secretion after chronic ammonia treatment reduces the level of synaptic proteins: in vitro and in vivo studies.
Topics: Ammonia; Animals; Antioxidants; Astrocytes; Female; Hepatic Encephalopathy; Nerve Tissue Proteins; N | 2014 |
Ammonia-induced senescence in cultured rat astrocytes and in human cerebral cortex in hepatic encephalopathy.
Topics: Ammonia; Animals; Astrocytes; Brain Edema; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cellu | 2015 |
Serum ammonia level for the evaluation of hepatic encephalopathy.
Topics: Adult; Ammonia; Diagnosis, Differential; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage | 2014 |
Clues for minimal hepatic encephalopathy in children with noncirrhotic portal hypertension.
Topics: Adolescent; Ammonia; Attention; Child; Child, Preschool; Electroencephalography; Executive Function; | 2014 |
Dysbalance of astrocyte calcium under hyperammonemic conditions.
Topics: Ammonia; Animals; Astrocytes; Calcium; Cerebellum; Glutamate-Ammonia Ligase; Hepatic Encephalopathy; | 2014 |
Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests.
Topics: Aged; Ammonia; Attention; Biomarkers; Blood Flow Velocity; Cerebellum; Cerebrovascular Circulation; | 2014 |
THDP17 decreases ammonia production through glutaminase inhibition. A new drug for hepatic encephalopathy therapy.
Topics: Ammonia; Caco-2 Cells; Cell Survival; Drug Discovery; Enzyme Inhibitors; Glutaminase; Hepatic Enceph | 2014 |
Induction of systemic oxidative stress leads to brain oedema in portacaval shunted rats.
Topics: Ammonia; Analysis of Variance; Animals; Biomarkers; Brain Edema; End Stage Liver Disease; Glutathion | 2014 |
[Hepatic encephalopathy. Early therapy is most important!].
Topics: Ammonia; Anti-Bacterial Agents; Early Diagnosis; Early Medical Intervention; Hepatic Encephalopathy; | 2014 |
[Pathogenesis, diagnosis and treatment of hepatic encephalopathies in patients with liver cirrhosis].
Topics: Adult; Aged; Ammonia; Citric Acid Cycle; Dipeptides; Event-Related Potentials, P300; Female; Hepatic | 2014 |
pH-sensitive microemulsion-based gels for removal of colonic ammonia: a novel preventative oral preparation for hepatic encephalopathy in rats.
Topics: Alanine Transaminase; Ammonia; Animals; Bilirubin; Body Weight; Disease Models, Animal; Electroencep | 2015 |
Bispectral index monitoring for diagnosis and assessment of severity of hepatic encephalopathy in cirrhotic patients.
Topics: Adult; Ammonia; Case-Control Studies; Female; Hepatic Encephalopathy; Humans; Lactulose; Liver Cirrh | 2015 |
[In Process Citation].
Topics: Ammonia; Clinical Trials as Topic; Dipeptides; Early Diagnosis; Early Medical Intervention; Evidence | 2015 |
Putative precipitating factors for hepatic encephalopathy in dogs: 118 cases (1991-2014).
Topics: Ammonia; Animals; Biomarkers; Databases, Factual; Dog Diseases; Dogs; Female; Hepatic Encephalopathy | 2015 |
Functional brain network changes associated with clinical and biochemical measures of the severity of hepatic encephalopathy.
Topics: Ammonia; Biomarkers; Brain; Brain Mapping; Female; Glasgow Coma Scale; Hepatic Encephalopathy; Human | 2015 |
The Impact of Spironolactone on the Severity of Portal-Systemic Collaterals and Hepatic Encephalopathy in Cirrhotic Rats.
Topics: Ammonia; Animals; Bile Ducts; Body Weight; Hemodynamics; Hepatic Encephalopathy; Kidney; Ligation; L | 2015 |
Endozepine-4 levels are increased in hepatic coma.
Topics: Adult; Aged; Ammonia; Biomarkers; Case-Control Studies; Diazepam Binding Inhibitor; Female; Hepatic | 2015 |
Low visual cortex GABA levels in hepatic encephalopathy: links to blood ammonia, critical flicker frequency, and brain osmolytes.
Topics: Ammonia; Brain Chemistry; Creatine; Female; Flicker Fusion; gamma-Aminobutyric Acid; Glutamine; Glyc | 2015 |
[Options in the treatment of hepatic encephalopathy].
Topics: Amino Acids, Branched-Chain; Ammonia; Anti-Bacterial Agents; Dipeptides; Hepatic Encephalopathy; Hum | 2015 |
Covert hepatic encephalopathy: elevated total glutathione and absence of brain water content changes.
Topics: Aged; Ammonia; Brain; Brain Edema; Creatine; Female; Glutathione; Hepatic Encephalopathy; Humans; Ma | 2016 |
Evaluation of mid- and long-term efficacy of shunt limiting for hepatic myelopathy after transjugular intrahepatic portosystemic shunt.
Topics: Adult; Aged; Ammonia; Female; Follow-Up Studies; Hepatic Encephalopathy; Humans; Hypertension, Porta | 2016 |
Hyperammonemic hepatic encephalopathy management through L-ornithin-L-aspartate administration in dogs.
Topics: Ammonia; Animals; Dipeptides; Dog Diseases; Dogs; Female; Hepatic Encephalopathy; Hyperammonemia; Ma | 2016 |
Clinical and Pathophysiological Characteristics of Cirrhotic Patients with Grade 1 and Minimal Hepatic Encephalopathy.
Topics: Aged; Ammonia; Bacteremia; Bacterial Translocation; DNA, Bacterial; Female; Hepatic Encephalopathy; | 2016 |
Gradual improvement of hyperammonemic hepatic encephalopathy after the extirpation of a large uterine leiomyoma in a woman with constipation and liver cirrhosis resulting from autoimmune hepatitis.
Topics: Ammonia; Constipation; Female; Hepatic Encephalopathy; Hepatitis, Autoimmune; Humans; Leiomyoma; Liv | 2016 |
Usefulness of Levocarnitine and/or Branched-Chain Amino Acids during Invasive Treatment for Hepatocellular Carcinoma.
Topics: Ablation Techniques; Aged; Aged, 80 and over; Albumins; Amino Acids, Branched-Chain; Ammonia; Carcin | 2015 |
The Influence of Finasteride on Mean and Relative Spectral Density of EEG Bands in Rat Model of Thioacetamide-Induced Hepatic Encephalopathy.
Topics: 5-alpha Reductase Inhibitors; Ammonia; Animals; Brain; Brain Waves; Central Nervous System Agents; D | 2016 |
Development of an experimental rat model of hyperammonemic encephalopathy and evaluation of the effects of rifaximin.
Topics: Ammonia; Animals; Behavior, Animal; Brain; Coma; Disease Models, Animal; Hepatic Encephalopathy; Hyp | 2016 |
Role of ammonia, inflammation, and cerebral oxygenation in brain dysfunction of acute-on-chronic liver failure patients.
Topics: Acute-On-Chronic Liver Failure; Adult; Ammonia; Arteries; Biomarkers; Brain; C-Reactive Protein; Fem | 2016 |
Abnormalities of voxel-based whole-brain functional connectivity patterns predict the progression of hepatic encephalopathy.
Topics: Ammonia; Analysis of Variance; Biomarkers; Brain; Brain Mapping; Cognition; Disease Progression; Fem | 2017 |
[RENDU-OSLER DISEASE: A RARE CAUSE OF AMMONIA ENCEPHALOPATHY].
Topics: Ammonia; Hepatic Encephalopathy; Humans; Male; Middle Aged; Rare Diseases; Telangiectasia, Hereditar | 2016 |
Factors contributing to the development of overt encephalopathy in liver cirrhosis patients.
Topics: Aged; Ammonia; Biomarkers; C-Reactive Protein; Disease Progression; Female; Follow-Up Studies; Hepat | 2016 |
The use of temporary portocaval shunt as a technical aid in auxiliary orthotopic liver transplantation.
Topics: Acetaminophen; Adolescent; Adult; Allografts; Ammonia; Analgesics, Non-Narcotic; Biopsy; Female; Gra | 2016 |
Lactulose reduces bacterial DNA translocation, which worsens neurocognitive shape in cirrhotic patients with minimal hepatic encephalopathy.
Topics: Aged; Ammonia; Bacterial Translocation; Biomarkers; Cognition; DNA, Bacterial; Female; Gastrointesti | 2017 |
Ammonia Level and Mortality in Acute Liver Failure: A Single-Center Experience.
Topics: Acute Kidney Injury; Adult; Ammonia; Female; Hepatic Encephalopathy; Humans; Liver Failure, Acute; L | 2016 |
Cerebrospinal fluid metabolomics highlights dysregulation of energy metabolism in overt hepatic encephalopathy.
Topics: Amino Acids; Ammonia; Energy Metabolism; Hepatic Encephalopathy; Humans; Metabolomics | 2016 |
Letter: stepwise diagnosis in covert hepatic encephalopathy - do not forget ammonia.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis | 2016 |
Letter: Stepwise diagnosis in covert hepatic encephalopathy-do not forget ammonia. Authors' reply.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis | 2016 |
Artesunate restores spatial learning of rats with hepatic encephalopathy by inhibiting ammonia-induced oxidative damage in neurons and dysfunction of glutamate signaling in astroglial cells.
Topics: Ammonia; Animals; Artemisinins; Artesunate; Astrocytes; Cell Line, Tumor; Glutamic Acid; Hepatic Enc | 2016 |
Magnetic Resonance Spectroscopy for Evaluating Portal-Systemic Encephalopathy in Patients with Chronic Hepatic Schistosomiasis Japonicum.
Topics: Aged; Aged, 80 and over; Ammonia; Brain; Chronic Disease; Female; Globus Pallidus; Glutamine; Hepati | 2016 |
The bile duct ligated rat: A relevant model to study muscle mass loss in cirrhosis.
Topics: Ammonia; Animals; Base Composition; Bile Ducts; Disease Models, Animal; Eating; Hepatic Encephalopat | 2017 |
Altered postural control and stability in cirrhotic patients with minimal hepatic encephalopathy correlate with cognitive deficits.
Topics: Accidental Falls; Ammonia; Attention; Case-Control Studies; Chi-Square Distribution; Cognition; Cogn | 2017 |
Taurine treatment preserves brain and liver mitochondrial function in a rat model of fulminant hepatic failure and hyperammonemia.
Topics: Adenosine Triphosphate; Ammonia; Animals; Brain; Hepatic Encephalopathy; Hyperammonemia; Liver; Live | 2017 |
Ammonia mediates cortical hemichannel dysfunction in rodent models of chronic liver disease.
Topics: Ammonia; Analysis of Variance; Animals; Bile Ducts; Biomarkers; Blotting, Western; Cerebral Cortex; | 2017 |
Sleep disturbances in patients of liver cirrhosis with minimal hepatic encephalopathy before and after lactulose therapy.
Topics: Adult; Ammonia; Disorders of Excessive Somnolence; Female; Flicker Fusion; Hepatic Encephalopathy; H | 2017 |
Reduction of manganese intake improves neuropsychological manifestations in rats with minimal hepatic encephalopathy.
Topics: Ammonia; Animals; Brain; Feces; Glutamate-Ammonia Ligase; Hepatic Encephalopathy; Manganese; Maze Le | 2017 |
Effects of raloxifene on portal hypertension and hepatic encephalopathy in cirrhotic rats.
Topics: Ammonia; Animals; Body Weight; Female; Fibrosis; Gene Expression Regulation; Hemodynamics; Hepatic E | 2017 |
Acute liver failure-induced death of rats is delayed or prevented by blocking NMDA receptors in brain.
Topics: Ammonia; Animals; Brain; Disease Models, Animal; Disease Progression; Dizocilpine Maleate; Excitator | 2008 |
Computerized psychometric testing in minimal encephalopathy and modulation by nitrogen challenge and liver transplant.
Topics: Adult; Aged; Ammonia; Biomarkers; Cognition; Electronic Data Processing; Female; Hepatic Encephalopa | 2008 |
NFkappaB in the mechanism of ammonia-induced astrocyte swelling in culture.
Topics: Active Transport, Cell Nucleus; Ammonia; Animals; Animals, Newborn; Antioxidants; Astrocytes; Brain | 2008 |
Neuropsychological impairment in severe acute viral hepatitis is due to minimal hepatic encephalopathy.
Topics: Adult; Ammonia; Blood Chemical Analysis; Female; Flicker Fusion; Hepatic Encephalopathy; Hepatitis, | 2009 |
Backflux of ammonia from brain to blood in human subjects with and without hepatic encephalopathy.
Topics: Ammonia; Brain; Brain Chemistry; Cerebrovascular Circulation; Computer Simulation; Hepatic Encephalo | 2009 |
Metabolic fate of isoleucine in a rat model of hepatic encephalopathy and in cultured neural cells exposed to ammonia.
Topics: Ammonia; Animals; Astrocytes; Brain; Carbon Radioisotopes; Cells, Cultured; Cholestasis; Citric Acid | 2009 |
Postural control in patients with liver cirrhosis: a posturographic study.
Topics: Adult; Aged; Aged, 80 and over; Ammonia; Ataxia; Case-Control Studies; Female; Hepatic Encephalopath | 2009 |
Congenital portal systemic encephalopathy misdiagnosed as senile dementia.
Topics: Aged, 80 and over; Alzheimer Disease; Ammonia; Angiography; Diagnostic Errors; Hepatic Encephalopath | 2009 |
Direct evidence for central proinflammatory mechanisms in rats with experimental acute liver failure: protective effect of hypothermia.
Topics: Ammonia; Animals; Brain Edema; CD11b Antigen; Cytokines; Disease Models, Animal; Gene Expression; He | 2009 |
Inhibitors of the mitochondrial permeability transition reduce ammonia-induced cell swelling in cultured astrocytes.
Topics: Ammonia; Animals; Astrocytes; Blood-Brain Barrier; Brain; Brain Edema; Cell Size; Cells, Cultured; C | 2009 |
Severity of organ failure is an independent predictor of intracranial hypertension in acute liver failure.
Topics: Adult; Ammonia; APACHE; Female; Hepatic Encephalopathy; Humans; Intensive Care Units; Intracranial H | 2009 |
Minocycline attenuates oxidative/nitrosative stress and cerebral complications of acute liver failure in rats.
Topics: Ammonia; Animals; Blotting, Western; Brain; Brain Chemistry; Disease Progression; Heme Oxygenase-1; | 2009 |
Predictors of nonresponse to lactulose for minimal hepatic encephalopathy in patients with cirrhosis.
Topics: Adult; Ammonia; Event-Related Potentials, P300; Female; Flicker Fusion; Hepatic Encephalopathy; Huma | 2009 |
Prolonged exposure to ammonia increases extracellular glutamate in cultured rat astrocytes.
Topics: Adenosine Triphosphate; Ammonia; Animals; Astrocytes; Cells, Cultured; Chromatography, High Pressure | 2009 |
Induction of NOS and nitrotyrosine expression in the rat striatum following experimental hepatic encephalopathy.
Topics: Ammonia; Animals; Astrocytes; Blotting, Western; Enzyme Induction; Glial Fibrillary Acidic Protein; | 2009 |
Changes in plasma amino acids during extracorporeal liver support by fractionated plasma separation and adsorption.
Topics: Amino Acids; Ammonia; Chromatography, High Pressure Liquid; Extracorporeal Circulation; Female; Hepa | 2010 |
Successful treatment of hepatic encephalopathy in a patient with acute lymphoblastic leukemia.
Topics: Adult; Alanine Transaminase; Ammonia; Antineoplastic Combined Chemotherapy Protocols; Aspartate Amin | 2009 |
Neurologic presentations of hepatic disease.
Topics: Ammonia; Animals; Brain; Diagnosis, Differential; gamma-Aminobutyric Acid; Hepatic Encephalopathy; H | 2010 |
Peripheral and splanchnic indole and oxindole levels in cirrhotic patients: a study on the pathophysiology of hepatic encephalopathy.
Topics: Aged; Ammonia; Female; Hepatic Encephalopathy; Humans; Indoles; Liver; Liver Circulation; Liver Cirr | 2010 |
[Analysis of the relationship between hepatorenal syndrome and plasma ammonia].
Topics: Adult; Aged; Ammonia; Biomarkers; Blood Urea Nitrogen; Case-Control Studies; Creatinine; Female; Hep | 2010 |
Encephalopathy assessment in children with extra-hepatic portal vein obstruction with MR, psychometry and critical flicker frequency.
Topics: Ammonia; Case-Control Studies; Child; Cognition; Constriction, Pathologic; Creatinine; Female; Flick | 2010 |
Portacaval anastomosis-induced hyperammonemia does not lead to oxidative stress.
Topics: Aldehydes; Ammonia; Animals; Biomarkers; Blotting, Western; Brain; Disease Models, Animal; Frontal L | 2010 |
Blood-brain barrier permeability for ammonia in patients with different grades of liver fibrosis is not different from healthy controls.
Topics: Aged; Ammonia; Blood-Brain Barrier; Brain; Capillary Permeability; Female; Glutamine; Hepatic Enceph | 2010 |
Ammonia and proinflammatory cytokines modify expression of genes coding for astrocytic proteins implicated in brain edema in acute liver failure.
Topics: Ammonia; Animals; Aquaporin 4; Astrocytes; Brain; Brain Edema; Cells, Cultured; Cytokines; Encephali | 2010 |
Human (13)N-ammonia PET studies: the importance of measuring (13)N-ammonia metabolites in blood.
Topics: Ammonia; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Hepatic Encephalopathy; Human | 2010 |
Brain MR imaging and 1H-MR spectroscopy changes in patients with extrahepatic portal vein obstruction from early childhood to adulthood.
Topics: Adolescent; Adult; Age Factors; Ammonia; Basal Ganglia; Child; Female; Hepatic Encephalopathy; Human | 2010 |
Gut flora and hepatic encephalopathy in patients with cirrhosis.
Topics: Ammonia; Anti-Infective Agents; Gastrointestinal Agents; Gastrointestinal Tract; Hepatic Encephalopa | 2010 |
Acute hepatic encephalopathy: diffusion-weighted and fluid-attenuated inversion recovery findings, and correlation with plasma ammonia level and clinical outcome.
Topics: Acute Disease; Adolescent; Adult; Aged; Ammonia; Cerebellum; Cerebral Cortex; Child; Diffusion Magne | 2010 |
A new experimental model for acute hepatic failure in rats.
Topics: Ammonia; Animals; Bilirubin; Creatine; Disease Models, Animal; Hepatectomy; Hepatic Encephalopathy; | 2010 |
Blood-brain barrier in liver failure: are cracks appearing in the wall?
Topics: Ammonia; Animals; Astrocytes; Blood-Brain Barrier; Brain Edema; Hepatic Encephalopathy; Humans; Live | 2010 |
Cerebral oedema in minimal hepatic encephalopathy due to extrahepatic portal venous obstruction.
Topics: Adolescent; Adult; Ammonia; Brain; Brain Edema; Constriction, Pathologic; Female; Flicker Fusion; He | 2010 |
[Ammonia as a cause for hepatic encephalopathy].
Topics: Ammonia; Confusion; Expectorants; Hepatic Encephalopathy; Humans; Spain | 2010 |
[Hepatic encephalopathy. L-ornithine-L-aspartate stimulate detoxification capacity of the liver].
Topics: Ammonia; Clinical Trials as Topic; Dipeptides; Hepatic Encephalopathy; Humans; Liver; Liver Function | 2010 |
[Myoinositol trends in HMRS brain spectrum of patients with hepatic encephalopathy].
Topics: Ammonia; Biomarkers; Choline; Creatine; Hepatic Encephalopathy; Humans; Inositol; Liver; Magnetic Re | 2010 |
Normal protein diet and L-ornithine-L-aspartate for hepatic encephalopathy.
Topics: Ammonia; Dietary Proteins; Dipeptides; Dose-Response Relationship, Drug; Follow-Up Studies; Hepatic | 2010 |
Effect of surgical portosystemic shunt on prevalence of minimal hepatic encephalopathy in children with extrahepatic portal venous obstruction: assessment by magnetic resonance imaging and psychometry.
Topics: Adolescent; Ammonia; Brain Edema; Child; Creatine; Cross-Sectional Studies; Female; Glutamine; Hepat | 2010 |
[Hepatic encephalopathy in patients with cirrhosis: new aspects and practical recommendations].
Topics: Ammonia; Diagnosis, Differential; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Liver Transplanta | 2010 |
[The relationship of CPS-I, OCT and hepatic encephalopathy].
Topics: Adult; Ammonia; Carbamoyl-Phosphate Synthase (Ammonia); Case-Control Studies; Female; Hepatic Enceph | 2010 |
Extracellular brain ammonia levels in association with arterial ammonia, intracranial pressure and the use of albumin dialysis devices in pigs with acute liver failure.
Topics: Albumins; Ammonia; Animals; Blood-Brain Barrier; Brain Chemistry; Disease Progression; Electroenceph | 2010 |
Infection and systemic inflammation, not ammonia, are associated with Grade 3/4 hepatic encephalopathy, but not mortality in cirrhosis.
Topics: Adult; Ammonia; Critical Care; Female; Hepatic Encephalopathy; Hepatitis A; Humans; Kaplan-Meier Est | 2011 |
Infection and systemic inflammation, not ammonia, are associated with Grade 3/4 hepatic encephalopathy, but not mortality in cirrhosis.
Topics: Adult; Ammonia; Critical Care; Female; Hepatic Encephalopathy; Hepatitis A; Humans; Kaplan-Meier Est | 2011 |
Infection and systemic inflammation, not ammonia, are associated with Grade 3/4 hepatic encephalopathy, but not mortality in cirrhosis.
Topics: Adult; Ammonia; Critical Care; Female; Hepatic Encephalopathy; Hepatitis A; Humans; Kaplan-Meier Est | 2011 |
Infection and systemic inflammation, not ammonia, are associated with Grade 3/4 hepatic encephalopathy, but not mortality in cirrhosis.
Topics: Adult; Ammonia; Critical Care; Female; Hepatic Encephalopathy; Hepatitis A; Humans; Kaplan-Meier Est | 2011 |
Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice.
Topics: Ammonia; Animals; Bilirubin; Brain; Cannabidiol; Cognition; Female; Hepatic Encephalopathy; Liver; L | 2011 |
An unusual trigger for a neurogenic left ventricular dysfunction: Tako-Tsubo syndrome associated with hepatic encephalopathy.
Topics: Ammonia; Coronary Angiography; Echocardiography; Electroencephalography; Epinephrine; Female; Heart | 2011 |
Different biochemical correlates for different neuropsychiatric abnormalities in patients with cirrhosis.
Topics: Adult; Aged; Ammonia; Biomarkers; C-Reactive Protein; Case-Control Studies; Electroencephalography; | 2011 |
Pro-inflammatory cytokines are raised in extrahepatic portal venous obstruction, with minimal hepatic encephalopathy.
Topics: Adolescent; Adult; Ammonia; Brain; Brain Edema; Case-Control Studies; Child; Diffusion Tensor Imagin | 2011 |
Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy.
Topics: Acetates; Ammonia; Animals; Astrocytes; Brain Chemistry; Chromatography, High Pressure Liquid; Chron | 2011 |
Nitric oxide levels in cirrhotic patients with hepatic encephalopathy.
Topics: Ammonia; C-Reactive Protein; Female; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Male; Nitric O | 2011 |
Microglia activation in hepatic encephalopathy in rats and humans.
Topics: Ammonia; Animals; Astrocytes; Autopsy; Calcium-Binding Proteins; Cell Movement; Cells, Cultured; Cer | 2011 |
Critical flicker frequency and continuous reaction times for the diagnosis of minimal hepatic encephalopathy: a comparative study of 154 patients with liver disease.
Topics: Adult; Aged; Aged, 80 and over; Ammonia; Female; Flicker Fusion; Hepatic Encephalopathy; Humans; Mal | 2011 |
Neuromonitoring in a porcine model of acute hepatic failure.
Topics: Ammonia; Animals; Brain Edema; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Evok | 2011 |
Selective cyclooxygenase inhibition improves hepatic encephalopathy in fulminant hepatic failure of rat.
Topics: Ammonia; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Gene Expression Reg | 2011 |
Spectral and dynamic electroencephalogram abnormalities are correlated to psychometric test performance in hepatic encephalopathy.
Topics: Ammonia; Analysis of Variance; Electroencephalography; Female; Hepatic Encephalopathy; Humans; Liver | 2011 |
Liver transplantation rapidly stops cerebral ammonia uptake in fulminant hepatic failure.
Topics: Adult; Ammonia; Brain; Female; Follow-Up Studies; Hepatic Encephalopathy; Humans; Liver Failure, Acu | 2011 |
p38 MAP kinase is a therapeutic target for hepatic encephalopathy in rats with portacaval shunts.
Topics: Ammonia; Animals; Blotting, Western; Cerebellum; Cerebral Cortex; Cognition; Disease Models, Animal; | 2011 |
Partial pressure of NH₃ in cirrhotic patients with and without hepatic encephalopathy.
Topics: Adult; Aged; Ammonia; Female; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Liver Function Tests; | 2011 |
Brain biomolecules oxidation in portacaval-shunted rats.
Topics: Aldehydes; Ammonia; Animals; Brain; Chromatography, High Pressure Liquid; Electrophoresis; Glutamate | 2011 |
Urinary ammonia excretion increases acutely during living donor liver transplantation.
Topics: Adult; Aged; Ammonia; Biomarkers; Female; Germany; Hepatectomy; Hepatic Encephalopathy; Homeostasis; | 2011 |
Interaction between cytokines and ammonia in the mitochondrial permeability transition in cultured astrocytes.
Topics: Ammonia; Animals; Astrocytes; Blotting, Western; Brain Edema; Cells, Cultured; Cytokines; Hepatic En | 2011 |
Absence of neuropsychological impairment in hyperammonaemia in healthy young adults; possible synergism in development of hepatic encephalopathy (HE) symptoms?
Topics: Adult; Ammonia; Analysis of Variance; Cross-Over Studies; Double-Blind Method; Fatigue; Hepatic Ence | 2011 |
Ornithine phenylacetate prevents disturbances of motor-evoked potentials induced by intestinal blood in rats with portacaval anastomosis.
Topics: Amino Acids; Ammonia; Animals; Brain; Disease Models, Animal; Evoked Potentials, Motor; Glutamine; H | 2012 |
Breath-ammonia testing of healthy subjects and patients with cirrhosis.
Topics: Adult; Aged; Ammonia; Breath Tests; Case-Control Studies; Comorbidity; Cost-Benefit Analysis; Female | 2012 |
Contribution of hyperammonemia and inflammatory factors to cognitive impairment in minimal hepatic encephalopathy.
Topics: Adult; Aged; Ammonia; Cognitive Dysfunction; Fatty Liver; Female; Hepatic Encephalopathy; Humans; Hy | 2012 |
Exploratory investigation on nitro- and phospho-proteome cerebellum changes in hyperammonemia and hepatic encephalopathy rat models.
Topics: Ammonia; Animals; Cerebellum; Cognition; Disease Models, Animal; Hepatic Encephalopathy; Humans; Hyp | 2012 |
A capillary blood ammonia bedside test following glutamine load to improve the diagnosis of hepatic encephalopathy in cirrhosis.
Topics: Administration, Oral; Adult; Aged; Ammonia; Biomarkers; Capillaries; Cohort Studies; Female; Follow- | 2011 |
Ammonia-induced brain swelling and neurotoxicity in an organotypic slice model.
Topics: Ammonia; Animals; Animals, Newborn; Brain; Brain Edema; Disease Models, Animal; Hepatic Encephalopat | 2011 |
Efficacy of oral L-ornithine L-aspartate in cirrhotic patients with hyperammonemic hepatic encephalopathy.
Topics: Administration, Oral; Ammonia; Dipeptides; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia | 2011 |
Prognostic value of venous blood ammonia in patients with out-of-hospital cardiac arrest.
Topics: Aged; Ammonia; Biomarkers; Chi-Square Distribution; Confidence Intervals; Emergency Medical Services | 2012 |
Altered resting-state brain activity at functional MR imaging during the progression of hepatic encephalopathy.
Topics: Ammonia; Analysis of Variance; Case-Control Studies; Disease Progression; Female; Hepatic Encephalop | 2012 |
Role of cerebral endothelial cells in the astrocyte swelling and brain edema associated with acute hepatic encephalopathy.
Topics: Ammonia; Animals; Astrocytes; Brain Edema; Cells, Cultured; Cerebrovascular Circulation; Culture Med | 2012 |
Regional reduction in gray and white matter volume in brains of cirrhotic patients: voxel-based analysis of MRI.
Topics: Aged; Ammonia; Atrophy; Brain; Cognition; Fatty Liver; Female; Hepatic Encephalopathy; Hepatitis B; | 2012 |
Selective impairments of resting-state networks in minimal hepatic encephalopathy.
Topics: Aged; Ammonia; Brain Mapping; Case-Control Studies; Female; Hepatic Encephalopathy; Humans; Magnetic | 2012 |
Psychometric hepatic encephalopathy score for the detection of minimal hepatic encephalopathy in Korean patients with liver cirrhosis.
Topics: Adult; Aged; Ammonia; Case-Control Studies; Chi-Square Distribution; Educational Status; Female; Hep | 2012 |
Serum endotoxin and inflammatory mediators in patients with cirrhosis and hepatic encephalopathy.
Topics: Adolescent; Adult; Aged; Ammonia; Biomarkers; Case-Control Studies; Endotoxins; Female; Hepatic Ence | 2012 |
Hepatic encephalopathy is associated with decreased cerebral oxygen metabolism and blood flow, not increased ammonia uptake.
Topics: Adult; Aged; Ammonia; Blood-Brain Barrier; Cerebrovascular Circulation; Cerebrum; Female; Hepatic En | 2013 |
Ammonia induces aquaporin-4 rearrangement in the plasma membrane of cultured astrocytes.
Topics: alpha-Synuclein; Ammonia; Animals; Aquaporin 4; Astrocytes; Brain Edema; Cell Membrane; Cells, Cultu | 2012 |
Correlation between interleukin-6 and ammonia in patients with overt hepatic encephalopathy due to cirrhosis.
Topics: Adult; Ammonia; Female; Hepatic Encephalopathy; Humans; Interleukin-6; Liver Cirrhosis; Male; Middle | 2013 |
Rifaximin may have a dramatic effect on hepatic encephalopathy.
Topics: Aged; Ammonia; Hepatic Encephalopathy; Humans; Male; Portasystemic Shunt, Transjugular Intrahepatic; | 2012 |
Impairment of short term memory in rats with hepatic encephalopathy due to bile duct ligation.
Topics: Ammonia; Animals; Bile Ducts; End Stage Liver Disease; Hepatic Encephalopathy; Hyperammonemia; Ligat | 2013 |
Metformin inhibits glutaminase activity and protects against hepatic encephalopathy.
Topics: Age Factors; Ammonia; Diabetes Complications; Enzyme Inhibitors; Female; Glutaminase; Hepatic Enceph | 2012 |
Inflammatory cascades driven by tumor necrosis factor-alpha play a major role in the progression of acute liver failure and its neurological complications.
Topics: Ammonia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; CD40 Ligand; Cerebrum; Dise | 2012 |
Venous blood ammonia can be associated with cerebral blood flow in hepatic encephalopathy.
Topics: Ammonia; Cerebrovascular Circulation; Cerebrum; Female; Hepatic Encephalopathy; Humans; Male; Oxygen | 2013 |
Muscle depletion increases the risk of overt and minimal hepatic encephalopathy: results of a prospective study.
Topics: Aged; Ammonia; Female; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Male; Malnutrition; Middle A | 2013 |
Reply: To PMID 22886493.
Topics: Ammonia; Cerebrovascular Circulation; Cerebrum; Female; Hepatic Encephalopathy; Humans; Male; Oxygen | 2013 |
Altered effective connectivity network of the basal ganglia in low-grade hepatic encephalopathy: a resting-state fMRI study with Granger causality analysis.
Topics: Ammonia; Basal Ganglia; Case-Control Studies; Demography; Female; Globus Pallidus; Hepatic Encephalo | 2013 |
Comparison of the effects of ammonia on brain mitochondrial function in rats and gulf toadfish.
Topics: Ammonia; Animals; Antimycin A; Batrachoidiformes; Brain; Cyanides; Electron Transport; Glutamine; He | 2002 |
An attempt to decrease ammonia levels after portacaval anastomosis in dogs: hepatic periarterial neurectomy.
Topics: Ammonia; Animals; Aspartate Aminotransferases; Dogs; Female; Hepatic Artery; Hepatic Encephalopathy; | 2002 |
Ammonia-induced heme oxygenase-1 expression in cultured rat astrocytes and rat brain in vivo.
Topics: Ammonia; Animals; Animals, Newborn; Antioxidants; Astrocytes; Cells, Cultured; Cerebral Cortex; Gene | 2002 |
Altered response to oral glutamine challenge as prognostic factor for overt episodes in patients with minimal hepatic encephalopathy.
Topics: Administration, Oral; Ammonia; Glutamine; Helicobacter Infections; Helicobacter pylori; Hepatic Ence | 2002 |
Understanding the mechanisms of cerebral complications in fulminant hepatic failure: fluxes better than levels.
Topics: Ammonia; Brain; Hepatic Encephalopathy; Humans; Liver Failure | 2002 |
[Portosystemic shunt via the left branch of portal vein for the prevention of encephalopathy following transjugular intrahepatic portosystemic shunt].
Topics: Adult; Aged; Ammonia; Animals; Female; Follow-Up Studies; Hepatic Encephalopathy; Humans; Male; Midd | 2002 |
Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study.
Topics: Amino Acids; Ammonia; Animals; Blood; Body Water; Brain; Brain Edema; Carbon Isotopes; Glucose; Hepa | 2003 |
Ammonia levels and the severity of hepatic encephalopathy.
Topics: Ammonia; Biomarkers; Blood Chemical Analysis; Blood Pressure Determination; Hepatic Encephalopathy; | 2003 |
Role of determination of partial pressure of ammonia in cirrhotic patients with and without hepatic encephalopathy.
Topics: Aged; Ammonia; Arteries; Female; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Liver Failure; Mal | 2003 |
The effects of early and late administration of inhibitors of inducible nitric oxide synthase in a thioacetamide-induced model of acute hepatic failure in the rat.
Topics: Ammonia; Animals; Enzyme Inhibitors; Guanidines; Hepatic Encephalopathy; Liver; Liver Failure, Acute | 2003 |
Albumin-based dialysis as an effective treatment for severe traumatic hepatic necrosis.
Topics: Accidental Falls; Adult; Alanine Transaminase; Albumins; Ammonia; Aspartate Aminotransferases; Bilir | 2003 |
Probiotics can treat hepatic encephalopathy.
Topics: Ammonia; Anti-Bacterial Agents; Digestive System; Hepatic Encephalopathy; Humans; Lactulose; Models, | 2003 |
HEPATIC coma and ammonia metabolism.
Topics: Ammonia; Coma; Hepatic Encephalopathy | 1953 |
Blood ammonia and electrolytes in hepatic coma.
Topics: Ammonia; Blood; Electrolytes; Hepatic Encephalopathy; Humans; Liver Cirrhosis | 1953 |
Uptake of ammonia by the brain in hepatic coma.
Topics: Ammonia; Brain; Coma; Hepatic Encephalopathy; Humans; Liver Diseases; Neurochemistry | 1954 |
Blood-ammonia levels in relation to hepatic coma and the administration of glutamic acid.
Topics: Ammonia; Blood; Coma; Glutamic Acid; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Liver Function | 1954 |
Hepatic coma.
Topics: Ammonia; Blood; Coma; Glutamates; Hepatic Encephalopathy; Liver Diseases | 1954 |
The plasma ammonia and glutamine content in patients with hepatic coma.
Topics: Ammonia; Blood; Glutamine; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Plasma | 1954 |
The mechanism of hepatic coma.
Topics: Ammonia; Coma; Hepatic Encephalopathy; Humans; Liver Diseases | 1955 |
Relationship of glutamic acid and blood ammonia to hepatic coma.
Topics: Ammonia; Blood; Coma; Glutamates; Glutamic Acid; Hepatic Encephalopathy; Humans; Liver Diseases | 1955 |
The role of ammonia in hepatic coma.
Topics: Ammonia; Blood; Coma; Hepatic Encephalopathy; Humans; Liver Diseases | 1955 |
Ammonia intoxication and hepatic coma.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver Diseases; Poisoning | 1956 |
Respiratory alkalosis in hepatic coma.
Topics: Alkalosis; Alkalosis, Respiratory; Ammonia; Blood; Hepatic Encephalopathy; Humans; Liver Diseases | 1956 |
HEPATIC coma and ammonia metabolism.
Topics: Ammonia; Coma; Glutamates; Hepatic Encephalopathy | 1956 |
Experimental observations on meat intoxication, ammonia accumulation and hepatic coma.
Topics: Amidohydrolases; Ammonia; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Hepatic Encephalopat | 1956 |
Studies in ammonia metabolism. I. Ammonia metabolism and glutamate therapy in hepatic coma.
Topics: Ammonia; Coma; Glutamates; Glutamic Acid; Hepatic Encephalopathy | 1956 |
The in vitro production of ammonium and amines by intestinal bacteria in relation to nitrogen toxicity as a factor in hepatic coma.
Topics: Amines; Ammonia; Ammonium Compounds; Bacteria; Bacteriology; Coma; Hepatic Encephalopathy; In Vitro | 1956 |
[Hepatic coma; new pathogenic and therapeutic considerations].
Topics: Ammonia; Coma; Hepatic Encephalopathy; Humans; Liver Diseases | 1956 |
[Hepatic coma; new pathogenic and therapeutic considerations].
Topics: Ammonia; Coma; Hepatic Encephalopathy; Humans; Liver Diseases | 1956 |
[Hepatic coma; new pathogenic and therapeutic considerations].
Topics: Ammonia; Coma; Hepatic Encephalopathy; Humans; Liver Diseases | 1956 |
[Hepatic coma; new pathogenic and therapeutic considerations].
Topics: Ammonia; Coma; Hepatic Encephalopathy; Humans; Liver Diseases | 1956 |
The effect of glutamate administration on blood ammonia level and its correlation with clinical status in patients with hepatic coma.
Topics: Ammonia; Coma; Glutamates; Glutamic Acid; Hematologic Tests; Hepatic Encephalopathy | 1956 |
The effect of glutamate administration on blood ammonia level and its correlation with clinical status in patients with hepatic coma.
Topics: Ammonia; Coma; Glutamates; Glutamic Acid; Hematologic Tests; Hepatic Encephalopathy | 1956 |
The effect of glutamate administration on blood ammonia level and its correlation with clinical status in patients with hepatic coma.
Topics: Ammonia; Coma; Glutamates; Glutamic Acid; Hematologic Tests; Hepatic Encephalopathy | 1956 |
The effect of glutamate administration on blood ammonia level and its correlation with clinical status in patients with hepatic coma.
Topics: Ammonia; Coma; Glutamates; Glutamic Acid; Hematologic Tests; Hepatic Encephalopathy | 1956 |
The role of ammonia in the production of hepatic coma.
Topics: Ammonia; Brain; Coma; Hepatic Encephalopathy; Humans; Keto Acids; Ketones; Neurochemistry | 1956 |
The role of ammonia in the production of hepatic coma.
Topics: Ammonia; Brain; Coma; Hepatic Encephalopathy; Humans; Keto Acids; Ketones; Neurochemistry | 1956 |
The role of ammonia in the production of hepatic coma.
Topics: Ammonia; Brain; Coma; Hepatic Encephalopathy; Humans; Keto Acids; Ketones; Neurochemistry | 1956 |
The role of ammonia in the production of hepatic coma.
Topics: Ammonia; Brain; Coma; Hepatic Encephalopathy; Humans; Keto Acids; Ketones; Neurochemistry | 1956 |
Glutamic acid in the treatment of hepatic coma and its relationship to blood ammonia levels.
Topics: Ammonia; Coma; Glutamates; Glutamic Acid; Hematologic Tests; Hepatic Encephalopathy; Humans; Liver D | 1957 |
Glutamic acid in the treatment of hepatic coma and its relationship to blood ammonia levels.
Topics: Ammonia; Coma; Glutamates; Glutamic Acid; Hematologic Tests; Hepatic Encephalopathy; Humans; Liver D | 1957 |
Glutamic acid in the treatment of hepatic coma and its relationship to blood ammonia levels.
Topics: Ammonia; Coma; Glutamates; Glutamic Acid; Hematologic Tests; Hepatic Encephalopathy; Humans; Liver D | 1957 |
Glutamic acid in the treatment of hepatic coma and its relationship to blood ammonia levels.
Topics: Ammonia; Coma; Glutamates; Glutamic Acid; Hematologic Tests; Hepatic Encephalopathy; Humans; Liver D | 1957 |
The metabolism of ammonia and alpha-keto-acids in liver disease and hepatic coma.
Topics: Ammonia; Coma; Hepatic Encephalopathy; Humans; Keto Acids; Ketones; Liver Diseases; Metabolic Diseas | 1957 |
AMMONIA metabolism and hepatic coma.
Topics: Ammonia; Coma; Hepatic Encephalopathy; Humans; Liver Diseases; Metabolic Diseases | 1957 |
Hepatic coma; a clinical study.
Topics: Ammonia; Biomedical Research; Coma; Hepatic Encephalopathy; Humans; Liver Diseases; Vascular Disease | 1957 |
Digestion of blood in the genesis of hepatic coma.
Topics: Ammonia; Coma; Digestion; Gastrointestinal Hemorrhage; Gastrointestinal Tract; Hemorrhage; Hepatic E | 1957 |
Cirrhosis of the liver; impending hepatic coma and increased blood ammonium concentrations during protein hydrolysate infusion.
Topics: Amino Acids; Ammonia; Ammonium Compounds; Digestion; Hepatic Encephalopathy; Liver Cirrhosis; Protei | 1957 |
Effect on portal blood ammonium concentration of administering methionine to patients with hepatic cirrhosis.
Topics: Ammonia; Ammonium Compounds; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Methionine; Neomycin | 1957 |
Ammonia metabolism and hepatic coma.
Topics: Ammonia; Hepatic Encephalopathy | 1957 |
Management of hepatocerebral intoxication.
Topics: Ammonia; Diet; Hepatic Encephalopathy; Humans | 1958 |
Some factors influencing cerebral ammonia production in relation to hepatic coma.
Topics: Ammonia; Hemorrhage; Hepatic Encephalopathy; Humans | 1958 |
Ammonium uptake by the extremities and brain in hepatic coma.
Topics: Ammonia; Ammonium Compounds; Brain; Extremities; Hemorrhage; Hepatic Encephalopathy; Humans | 1958 |
The role of ammonia intoxication in hepatic coma.
Topics: Ammonia; Hepatic Encephalopathy; Humans | 1958 |
Treatment of hepatic coma: use of certain Krebs' urea cycle intermediates (L-arginine, DL-ornithine).
Topics: Amino Acids; Ammonia; Arginine; Citric Acid Cycle; Hepatic Encephalopathy; Humans; Ornithine; Urea | 1958 |
[Ammonia poisoning in etiology of hepatic coma].
Topics: Ammonia; Hepatic Encephalopathy; Humans | 1958 |
Alterations in blood ammonia in dogs following total hepatectomy and abdominal evisceration.
Topics: Ammonia; Animals; Dogs; Gastrointestinal Tract; Hepatectomy; Hepatic Encephalopathy; Humans; Liver | 1958 |
The measurement of changes in acetylcholine level (ACh) in rat brain following ammonium ion intoxication and its possible bearing on the problem of hepatic coma.
Topics: Acetylcholine; Ammonia; Ammonium Compounds; Animals; Brain; Hepatic Encephalopathy; Neurochemistry; | 1958 |
Ammonia intoxication following ureterosigmoidostomy in a patient with liver disease.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Liver Diseases; Medical Records; Ureter; U | 1958 |
AMMONIA toxicity and hepatic coma.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver | 1959 |
[Hepatic coma and artificial kidney].
Topics: Ammonia; Body Fluids; Hepatic Encephalopathy; Humans; Kidneys, Artificial; Water-Electrolyte Balance | 1958 |
Studies in ammonia metabolism. III. The experimental production of coma by carotid arterial infusion of ammonium salts.
Topics: Ammonia; Ammonium Compounds; Coma; Hepatic Encephalopathy; Salts | 1958 |
[Portocaval encephalopathy].
Topics: Ammonia; Hepatic Encephalopathy; Humans | 1959 |
[Electroencephalographical study of hepatic encephalopathy].
Topics: Ammonia; Electroencephalography; Hepatic Encephalopathy; Humans | 1961 |
[Research on the ammonium-binding action of aspartic acid in hepatic diseases].
Topics: Ammonia; Ammonium Compounds; Aspartic Acid; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Liver D | 1960 |
[Portal encephalopathy. Clinical and metabolic study].
Topics: Ammonia; Diet; Hepatic Encephalopathy; Humans; Liver Diseases; Neurologic Manifestations; Nutrition | 1961 |
[The significance of blood ammonia for the pathogenesis of hepatic coma].
Topics: Ammonia; Hepatic Encephalopathy; Humans | 1961 |
Effect of alterations in blood pH on distribution of ammonia from blood to cerebrospinal fluid in patients in hepatic coma.
Topics: Ammonia; Blood; Blood Chemical Analysis; Hepatic Encephalopathy; Humans | 1960 |
Some observations on hepatic coma with special reference to ammonia metabolism.
Topics: Ammonia; Hepatic Encephalopathy; Humans | 1960 |
[Arginase and experimental hyperammoniemia. II. Action of arginase on experimental portacaval encephalopathy in the dog].
Topics: Amidohydrolases; Ammonia; Animals; Arginase; Brain; Brain Diseases; Dogs; Hepatic Encephalopathy; Hu | 1962 |
[Relation of blood ammonia, the electroencephalogram and the state of consciousness in hepatic cirrhosis].
Topics: Ammonia; Consciousness; Digestion; Electroencephalography; Hepatic Encephalopathy; Humans; Liver Cir | 1962 |
[Ammonia levels of human blood following injection of protein hydrolysates in relation to hepatic coma].
Topics: Ammonia; Hepatic Encephalopathy; Humans; Injections; Protein Hydrolysates | 1962 |
A double-blind study of the effect of ammonium infusion on psychological functioning in cirrhotic patients.
Topics: Ammonia; Ammonium Compounds; Double-Blind Method; Hepatic Encephalopathy; Humans; Mental Processes | 1962 |
[Ammonia and hepatic coma].
Topics: Ammonia; Hepatic Encephalopathy; Humans | 1961 |
[Blood ammonium, glutamine in the cerebrospinal fluid, the electroencephalogram and the neurological examination in relation to states of consciousness in hepatic patients].
Topics: Ammonia; Ammonium Compounds; Consciousness; Electroencephalography; Glutamine; Hepatic Encephalopath | 1961 |
[Glutaminorachia during liver cirrhosis. Semeiological value of its modifications in "hepatic encephalopathies"].
Topics: Ammonia; Cerebrospinal Fluid; Glutamine; Hepatic Encephalopathy; Humans; Liver Cirrhosis | 1962 |
Studies of the blood ammonia in liver disease. Its diagnostic, prognostic, and therapeutic significance.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Liver Diseases; Prognosis | 1963 |
[Hyperammonemia and hepatic insufficiency].
Topics: Ammonia; Blood Chemical Analysis; Chemical and Drug Induced Liver Injury; Hepatic Encephalopathy; He | 1963 |
Hepatic coma and ammonia metabolism in dogs.
Topics: Ammonia; Animals; Dogs; Hepatic Encephalopathy | 1963 |
An extracorporeal device for hepatic coma.
Topics: Ammonia; Animals; Heart; Heart, Artificial; Hepatic Encephalopathy; Humans | 1963 |
BLOOD AMMONIA REDUCTION BY POTASSIUM EXCHANGE RESIN. EXPERIMENTATION IN ECK-FISTULA DOGS.
Topics: Ammonia; Animals; Dogs; Fistula; Hepatic Encephalopathy; Hypokalemia; Ion Exchange Resins; Portacava | 1963 |
THE TREATMENT OF EXPERIMENTAL HEPATIC COMA BY PARABIOTIC CROSS CIRCULATION.
Topics: Ammonia; Animals; Blood; Cross Circulation; Dogs; Hepatectomy; Hepatic Encephalopathy; Parabiosis; R | 1963 |
WHOLE-BODY HYPOTHERMIA IN AMMONIA INTOXICATION. EFFECT ON MONKEYS WITH PORTACAVAL SHUNTS.
Topics: Ammonia; Animals; Blood; Haplorhini; Hepatic Encephalopathy; Hypothermia; Hypothermia, Induced; Port | 1963 |
[ECK'S FISTULA SYNDROME].
Topics: Ammonia; Blood Chemical Analysis; Electroencephalography; Fistula; Hepatic Encephalopathy; Portacava | 1963 |
DRUGS RELATED TO THE EXACERBATION OR AMELIORATION OF HEPATIC COMA AND THEIR EFFECTS ON AMMONIA TOXICITY.
Topics: Acetazolamide; Ammonia; Ammonium Chloride; Arginine; Chlorothiazide; Cortisone; Formaldehyde; Glutam | 1963 |
[THE IMPORTANCE OF NEOMYCIN IN THE TREATMENT OF HEPATIC COMA IN SURGICAL DISEASES].
Topics: Ammonia; Blood Chemical Analysis; Esophageal and Gastric Varices; Hepatic Encephalopathy; Humans; Li | 1963 |
LIVER-BRAIN RELATIONSHIPS IN HEPATIC COMA WITH SPECIAL REFERENCE TO AMMONIA AND KETO ACID METABOLISM.
Topics: Amino Acids; Ammonia; Blood; Blood Glucose; Brain; Glutamates; Glutamine; Glutarates; Hepatic Enceph | 1963 |
DISTRIBUTION OF AMMONIA ACROSS THE BLOODCEREBROSPINAL FLUID BARRIER IN PATIENTS WITH HEPATIC FAILURE.
Topics: Ammonia; Blood; Blood-Brain Barrier; Cerebrospinal Fluid; Hepatic Encephalopathy; Humans; Liver Cirr | 1963 |
THE METABOLISM OF THE VOLATILE AMINES. IV. THE ROLE OF DRUGS IN THE PATHOGENESIS OF HEPATIC ENCEPHALOPATHY.
Topics: Amines; Ammonia; Animals; Blood Chemical Analysis; Brain Diseases; Chlorothiazide; Diuretics; Dogs; | 1963 |
EFFECT OF UREASE INHIBITION ON AMMONIA INTOXICATION IN DOGS.
Topics: Ammonia; Blood Chemical Analysis; Chlormerodrin; Diuretics; Dogs; Enzyme Inhibitors; Hepatic Encepha | 1964 |
COURSE OF RECURRENT CHOLEMIA FOLLOWED WITH BLOOD AMMONIA DETERMINATIONS.
Topics: Ammonia; Blood Chemical Analysis; Gastrointestinal Diseases; Geriatrics; Glucose; Hepatic Encephalop | 1963 |
SOME EFFECTS OF INDUCTION OF UREASE IMMUNITY IN PATIENTS WITH HEPATIC INSUFFICIENCY.
Topics: Adolescent; Ammonia; Antibodies; Blood Chemical Analysis; Child; Dietary Proteins; Hepatic Encephalo | 1963 |
TREATMENT OF PROGRESSIVE AMMONIA INTOXICATION BY EXCLUSION OF THE COLON.
Topics: Ammonia; Blood; Chemical and Drug Induced Liver Injury; Colon; Hepatic Encephalopathy; Hepatitis; Po | 1964 |
BLOOD AND CEREBROSPINAL FLUID AMMONIA AND GLUTATHIONE LEVELS IN LIVER DISEASE, AND THE EFFECT OF INTRAVENOUS GLUTAMATE ON THESE LEVELS.
Topics: Ammonia; Anemia; Blood Chemical Analysis; Cerebrospinal Fluid; Child; Glutamates; Glutamic Acid; Glu | 1963 |
SOME EFFECTS OF UREASE IMMUNITY IN HEPATIC INSUFFICIENCY.
Topics: Allergy and Immunology; Ammonia; Blood; Hemagglutination; Hepatic Encephalopathy; Hepatic Insufficie | 1964 |
[TREATMENT OF PORTO-CAVAL ENCEPHALOPATHY BY EXCLUSION OR TOTAL RESECTION OF THE COLON].
Topics: Ammonia; Blood Chemical Analysis; Brain Diseases; Colon; Hepatic Encephalopathy; Humans; Portacaval | 1963 |
[PORTACAVAL ENCEPHALOPATHY].
Topics: Ammonia; Brain Diseases; Diagnosis, Differential; Hepatic Encephalopathy; Humans; Metabolism; Portac | 1963 |
[EXPERIMENTAL STUDIES ON THE ROLE OF AMMONIA IN HEPATIC ENCEPHALOPATHY].
Topics: Ammonia; Cats; Dogs; Electroencephalography; Hepatic Encephalopathy; Research; Toxicology | 1963 |
THE METABOLISM OF THE VOLATILE AMINES: VI. THE IDENTIFICATION OF THE VOLATILE BASE PRESENT IN BLOOD.
Topics: Alkalies; Amines; Ammonia; Blood Chemical Analysis; Brain Diseases; Chromatography; Hepatic Encephal | 1963 |
[HEPATIC COMA].
Topics: Adrenal Cortex Hormones; Ammonia; Arginine; Diagnosis; Diagnosis, Differential; Dialysis; Fluid Ther | 1963 |
[ORAL TREATMENT OF HYPERAMMONIEMIA BY CALCIUM ALPHA-KETOGLUTARATE].
Topics: Administration, Oral; Ammonia; Blood Chemical Analysis; Hepatic Encephalopathy; Humans; Hyperammonem | 1964 |
[HEPATIC COMA].
Topics: Ammonia; Arginine; Aspartate Aminotransferases; Blood; Blood Protein Electrophoresis; Clinical Labor | 1963 |
THE METABOLISM OF THE VOLATILE AMINES: VII. THE CLINICAL SIGNIFICANCE OF TWO COMPONENTS OF THE BLOOD AMMONIA LEVEL.
Topics: Amines; Ammonia; Arginine; Asparagine; Blood Chemical Analysis; Glutamates; Glutamine; Hematologic T | 1964 |
[COMA DURING THE DEVELOPMENT OF LIVER CIRRHOSIS].
Topics: Ammonia; Blood Chemical Analysis; Coma; Diagnosis, Differential; Hepatic Encephalopathy; Humans; Ion | 1963 |
[HEPATIC ENCEPHALOPATHY].
Topics: Ammonia; Blood; Brain Diseases; Electroencephalography; Hepatic Encephalopathy; Hepatitis; Hepatitis | 1964 |
[THE PHYSIOPATHOLOGY AND TREATMENT OF HEPATIC COMA].
Topics: Alkalosis; Ammonia; Anti-Bacterial Agents; Antibiotics, Antitubercular; Arginine; Bilirubin; Blood C | 1964 |
[HEPATIC COMA].
Topics: Ammonia; Anti-Bacterial Agents; Antibiotics, Antitubercular; Blood; Diuretics; Gastrointestinal Hemo | 1964 |
[VALUE OF THE STUDY OF THE BLOOD AMMONIA IN HEPATIC DISEASES].
Topics: Ammonia; Blood Chemical Analysis; Diagnosis, Differential; Gastrointestinal Hemorrhage; Hemorrhage; | 1964 |
THE MANAGEMENT OF HEPATIC COMA.
Topics: Acetazolamide; Adrenal Cortex Hormones; Alkalosis; Ammonia; Blood Transfusion; Chlorothiazide; Diet; | 1964 |
[DETERMINATION OF AMMONIA IN DEPROTEINIZED BLOOD].
Topics: Amino Acids; Ammonia; Asparagine; Biomedical Research; Blood Chemical Analysis; Blood Proteins; Glut | 1964 |
STUDIES OF RAT LIVER AND KIDNEY ENZYMES. II. RESPONSE TO DIETARY PROTEIN DEFICIENCY AND REPLETION DURING CHRONIC ADMINISTRATION OF AMMONIUM ACETATE AND L-GLUTAMINE.
Topics: Acetates; Adaptation, Physiological; Ammonia; Arginine; Dietary Proteins; Enzymes; Glutamates; Gluta | 1964 |
[DETERMINATION OF THE AMMONIA CONTENT IN DEPROTEINIZED BLOOD].
Topics: Ammonia; Asparagine; Blood Chemical Analysis; Brain Diseases; Glycols; Hepatic Encephalopathy; Indic | 1964 |
[CASE OF PERITONEAL DIALYSIS IN A PATIENT WITH CIRRHOSIS IN COMA WITH INFECTED ASCITES].
Topics: Ammonia; Ascites; Blood Chemical Analysis; Coma; Dialysis; Fluid Therapy; Hematocrit; Hepatic Enceph | 1964 |
[A STUDY OF THE FREE AMINO ACIDS IN THE SERUM OF LIVER DISEASES].
Topics: Alanine; Amino Acids; Ammonia; Animals; Arginine; Blood; Carbon Tetrachloride; Chemical and Drug Ind | 1964 |
TOXIC EFFECTS OF INGESTED WHOLE PROTEINS AND AMINO ACID MIXTURES IN PATIENTS WITH PORTAL SYSTEMIC ENCEPHALOPATHY.
Topics: Amino Acids; Ammonia; Antifibrinolytic Agents; Blood Chemical Analysis; Dietary Proteins; Eating; El | 1964 |
DISTRIBUTION OF AMMONIA IN CELLS AND PLASMA.
Topics: Alkalosis; Ammonia; Blood Chemical Analysis; Erythrocytes; Hepatic Encephalopathy; Liver Cirrhosis; | 1964 |
CEREBRAL ADENOSINE TRIPHOSPHATE IN RATS WITH AMMONIA-INDUCED COMA.
Topics: Acetates; Adenosine Triphosphate; Ammonia; Ammonium Compounds; Antioxidants; Brain Chemistry; Cerebr | 1964 |
ORAL CATION EXCHANGE RESINS FOR TREATMENT OF AMMONIA INTOXICATION.
Topics: Alcoholism; Ammonia; Blood; Cation Exchange Resins; Drug Therapy; Esophageal and Gastric Varices; Ga | 1964 |
[HEPATIC COMA].
Topics: Ammonia; Blood; Drug Therapy; Hepatic Encephalopathy; Hepatitis; Hepatitis A; Humans; Hydrocortisone | 1964 |
EFFECT OF HYDROCORTISONE ON BLOOD AMMONIA CONCENTRATIONS IN HEPATIC DISEASE.
Topics: Ammonia; Ammonium Chloride; Blood; Drug Therapy; Hepatic Encephalopathy; Humans; Hydrocortisone; Liv | 1964 |
BODY AND SERUM POTASSIUM IN LIVER DISEASE. II. RELATIONSHIPS TO ARTERIAL AMMONIA, BLOOD PH, AND HEPATIC COMA.
Topics: Ammonia; Blood; Chlorothiazide; Hepatic Encephalopathy; Humans; Hydrogen-Ion Concentration; Hypokale | 1965 |
[ACTION OF AMMONIUM IN THE PATHOGENESIS OF CEREBRAL FUNCTIONS IN HEART FAILURE].
Topics: Ammonia; Ammonium Compounds; Blood; Heart Failure; Hepatic Encephalopathy; Humans; Hypoxia, Brain; L | 1964 |
[METABOLIC AND RESPIRATORY DISORDERS OF LIVER INSUFFICIENCY].
Topics: Acidosis; Acidosis, Respiratory; Alkalosis; Ammonia; Ascites; Biomedical Research; Blood Gas Analysi | 1965 |
MECHANISM OF HEPATIC COMA.
Topics: Ammonia; Blood; Diagnosis; Glutamine; Hepatic Encephalopathy; Humans; Intestine, Small; Intestines; | 1964 |
ION EXCHANGE RESINS IN HEPATIC COMA.
Topics: Ammonia; Blood; Calcium; Calcium, Dietary; Hepatic Encephalopathy; Humans; Ion Exchange Resins; Sodi | 1964 |
MECHANISM OF HEPATIC COMA IN SURGERY.
Topics: Ammonia; Blood; Hepatic Encephalopathy; Humans; Ligases; Liver; Liver Function Tests; Neurologic Man | 1964 |
ACUTE FATTY LIVER OF PREGNANCY WITH HEPATIC COMA AND MALLORY-WEISS SYNDROME: REPORT OF A CASE.
Topics: Ammonia; Blood; Drug Therapy; Fatty Liver; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Hepa | 1965 |
PRELIMINARY STUDIES ON EXPERIMENTAL HYPERBILIRUBINEMIA AND HEPATIC COMA IN THE HORSE.
Topics: Ammonia; Animals; Blood Chemical Analysis; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 1965 |
TREATMENT OF CHRONIC PORTAL-SYSTEMIC ENCEPHALOPATHY BY COLECTOMY.
Topics: Ammonia; Blood Chemical Analysis; Colectomy; Electroencephalography; Hepatic Encephalopathy; Humans; | 1965 |
AMMONIA METABOLISM AND HEPATIC COMA IN HEPATOSPLENIC SCHISTOSOMIASIS: PATIENTS STUDIED BEFORE AND AFTER PORTACAVAL SHUNT.
Topics: Ammonia; Ammonium Chloride; Antimony; Collateral Circulation; Drug Therapy; Electroencephalography; | 1965 |
DIPHENHYDRAMINE (BENADRYL) HYDROCHLORIDE IN THE TREATMENT OF AMMONIA INTOXICATION.
Topics: Amino Acids; Ammonia; Animals; Blood; Blood Urea Nitrogen; Diphenhydramine; Dogs; Hepatic Encephalop | 1965 |
ILEOSTOMY PROTECTS DOGS FROM MEAT INTOXICATION.
Topics: Ammonia; Blood; Colon; Dietary Proteins; Dogs; Hepatic Encephalopathy; Ileostomy; Meat; Portacaval S | 1965 |
The cerebral and peripheral uptake of ammonia in liver disease with an hypothesis for the mechanism of hepatic coma.
Topics: Ammonia; Blood; Brain; Cardiovascular System; Coma; Hepatic Encephalopathy; Liver Diseases | 1955 |
Glutamic acid in hepatic coma.
Topics: Ammonia; Blood; Coma; Glutamates; Glutamic Acid; Hepatic Encephalopathy; Humans; Liver Diseases | 1955 |
An extracorporeal device to lower blood ammonia levels in hepatic coma.
Topics: Ammonia; Hematologic Tests; Hepatic Encephalopathy; Kidney; Kidneys, Artificial | 1962 |
[Blood ammonia curve in patients with hepatic coma].
Topics: Ammonia; Hepatic Encephalopathy; Humans | 1962 |
Successful treatment of refractory cerebral oedema in ecstasy/cocaine-induced fulminant hepatic failure using a new high-efficacy liver detoxification device (FPSA-Prometheus).
Topics: Adult; Ammonia; Brain Edema; Cocaine; Encephalocele; Follow-Up Studies; Hepatic Encephalopathy; Huma | 2003 |
[Because hepatic encephalopathy is a frequent contributing factor. Patients with liver cirrhosis are poorer drivers].
Topics: Accidents, Traffic; Ammonia; Dipeptides; Hepatic Encephalopathy; Humans; Liver Cirrhosis | 2003 |
Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis.
Topics: Amino Acids; Ammonia; C-Reactive Protein; Female; Hepatic Encephalopathy; Humans; Hyperammonemia; In | 2004 |
Hyperammonemia impairs long-term potentiation in hippocampus by altering the modulation of cGMP-degrading phosphodiesterase by protein kinase G.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Ammonia; Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kina | 2004 |
First report of cryopreserved human hepatocytes based bioartificial liver successfully used as a bridge to liver transplantation.
Topics: Adult; Ammonia; Bilirubin; Female; Hepatic Encephalopathy; Hepatocytes; Humans; Liver Transplantatio | 2004 |
Diffusion MRI shows increased water apparent diffusion coefficient in the brains of cirrhotics.
Topics: Adult; Aged; Ammonia; Brain; Diffusion Magnetic Resonance Imaging; Female; Hepatic Encephalopathy; H | 2004 |
[Cirrhotic liver gives up in breaking up of ammonia. Poison for the brain].
Topics: Ammonia; Clinical Trials as Topic; Dipeptides; Hepatic Encephalopathy; Humans; Lactulose; Liver Cirr | 2004 |
Oral glutamine challenge and magnetic resonance spectroscopy in three patients with congenital portosystemic shunts.
Topics: Administration, Oral; Adult; Ammonia; Area Under Curve; Brain; Cardiovascular Abnormalities; Female; | 2004 |
[Pathogenesis of hepatic encephalopathy].
Topics: Amino Acids; Ammonia; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans | 2004 |
Regional differences in cerebral blood flow and cerebral ammonia metabolism in patients with cirrhosis.
Topics: Adult; Aged; Ammonia; Brain; Cerebellum; Cerebrovascular Circulation; Corpus Striatum; Female; Hepat | 2004 |
[Albumin dialysis MARS (Molecular Adsorbent Recirculating System) as a bridge for liver transplantation in acute liver failure. Report of three cases].
Topics: Acute Kidney Injury; Adult; Albumins; Ammonia; Bilirubin; Biomarkers; Blood Urea Nitrogen; Creatinin | 2004 |
Valproic acid-induced hyperammonemia: a case report.
Topics: Ammonia; Anticonvulsants; Blood Urea Nitrogen; Consciousness Disorders; Diagnosis, Differential; Dru | 2004 |
[Hepatic encephalopathy: clinical aspects and pathogenesis].
Topics: Ammonia; Brain; Diagnosis, Differential; Flicker Fusion; Hepatic Encephalopathy; Humans; Neurologic | 2004 |
Effect of antibiotics, prebiotics and probiotics in treatment for hepatic encephalopathy.
Topics: Ammonia; Anti-Bacterial Agents; Clinical Trials as Topic; Hepatic Encephalopathy; Humans; Intestinal | 2005 |
Long-term results of partial splenic artery embolization as supplemental treatment for portal-systemic encephalopathy.
Topics: Adult; Aged; Aged, 80 and over; Ammonia; Balloon Occlusion; Embolization, Therapeutic; Female; Follo | 2005 |
Comparison of probiotics and lactulose in the treatment of minimal hepatic encephalopathy in rats.
Topics: Ammonia; Animals; Endotoxins; Gastrointestinal Agents; Hepatic Encephalopathy; Incidence; Lactulose; | 2005 |
[MARS and treatment of hepatic encephalopathy].
Topics: Ammonia; Clinical Trials as Topic; Dialysis; Hepatic Encephalopathy; Humans; Sorption Detoxification | 2005 |
Neostigmine for the treatment of acute hepatic encephalopathy with acute intestinal pseudo-obstruction in a cirrhotic patient.
Topics: Air; Ammonia; Blood Pressure; Cholinesterase Inhibitors; Electrolytes; Enema; Fibrosis; Hepatic Ence | 2005 |
[Detection of subclinical and overt hepatic encephalopathy and treatment control after L-ornithine-L-aspartate medication by magnetic resonance spectroscopy ((1)H-MRS)].
Topics: Adult; Ammonia; Brain; Choline; Combined Modality Therapy; Creatinine; Diet, Protein-Restricted; Dip | 2005 |
Neuropsychological and neurophysiological evaluation in cirrhotic patients with minimal hepatic encephalopathy undergoing liver transplantation.
Topics: Ammonia; Electroencephalography; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Liver Transplantat | 2005 |
EDTA should be the anticoagulant of choice for the measurement of plasma ammonia: report of a problem sample.
Topics: Ammonia; Anticoagulants; Edetic Acid; Hepatic Encephalopathy; Humans; Reproducibility of Results; Se | 2005 |
Ammonia toxicity under hyponatremic conditions in astrocytes: de novo synthesis of amino acids for the osmoregulatory response.
Topics: Alanine; Amino Acids; Ammonia; Ammonium Chloride; Animals; Animals, Newborn; Astrocytes; Brain Edema | 2005 |
Role of oxidative stress in the ammonia-induced mitochondrial permeability transition in cultured astrocytes.
Topics: Ammonia; Ammonium Chloride; Animals; Animals, Newborn; Antioxidants; Astrocytes; Brain; Cell Membran | 2005 |
Differential effects of ammonia on the benzodiazepine modulatory site on the GABA-A receptor complex of human brain.
Topics: Ammonia; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Dose-Response Relationship, Drug | 2005 |
Quantification of changes in electroencephalographic power spectra in a patient with Budd-Chiari-syndrome after implantation of a transjugular intrahepatic portosystemic stent shunt (TIPSS).
Topics: Adult; Alpha Rhythm; Ammonia; Brain; Budd-Chiari Syndrome; Cholinesterases; Electroencephalography; | 2005 |
Hyperammonaemia reduces intracellular 22Na (sodium) ion and extracellular 86Rb ion concentrations in the blood-brain barrier of the rat.
Topics: Ammonia; Animals; Blood-Brain Barrier; Carbon Radioisotopes; Choroid Plexus; Diffusion; Disease Mode | 2005 |
Ammonia-mediated LTP inhibition: effects of NMDA receptor antagonists and L-carnitine.
Topics: Adenosine Triphosphate; Ammonia; Animals; Carnitine; Cell Respiration; Dose-Response Relationship, D | 2005 |
Images of interest. Hepatobiliary and pancreatic: colonic obstruction and hepatic encephalopathy.
Topics: Aged; Ammonia; Biomarkers; Colonic Diseases; Colonoscopy; Diagnosis, Differential; Female; Hepatic E | 2005 |
Evaluation of plasma ammonia levels in patients with acute liver failure and chronic liver disease and its correlation with the severity of hepatic encephalopathy and clinical features of raised intracranial tension.
Topics: Adult; Ammonia; Brain Edema; Chronic Disease; Female; Hepatic Encephalopathy; Humans; Intracranial H | 2005 |
Mechanisms of ammonia-induced cell death in rat cortical neurons: roles of NMDA receptors and glutathione.
Topics: Ammonia; Ammonium Chloride; Animals; Animals, Newborn; Apoptosis; Cell Survival; Cells, Cultured; Ce | 2005 |
Predictive value of arterial ammonia for complications and outcome in acute liver failure.
Topics: Adolescent; Adult; Aged; Ammonia; Biomarkers; Epidemiologic Methods; Female; Hepatic Encephalopathy; | 2006 |
Predictive value of arterial ammonia for complications and outcome in acute liver failure.
Topics: Adolescent; Adult; Aged; Ammonia; Biomarkers; Epidemiologic Methods; Female; Hepatic Encephalopathy; | 2006 |
Predictive value of arterial ammonia for complications and outcome in acute liver failure.
Topics: Adolescent; Adult; Aged; Ammonia; Biomarkers; Epidemiologic Methods; Female; Hepatic Encephalopathy; | 2006 |
Predictive value of arterial ammonia for complications and outcome in acute liver failure.
Topics: Adolescent; Adult; Aged; Ammonia; Biomarkers; Epidemiologic Methods; Female; Hepatic Encephalopathy; | 2006 |
Relationship between tumor necrosis factor-alpha and ammonia in patients with hepatic encephalopathy due to chronic liver failure.
Topics: Aged; Ammonia; Biomarkers; Chronic Disease; Disease Progression; Enzyme-Linked Immunosorbent Assay; | 2005 |
Brain metabolism of 13N-ammonia during acute hepatic encephalopathy in cirrhosis measured by positron emission tomography.
Topics: Acute Disease; Adult; Aged; Ammonia; Blood-Brain Barrier; Brain; Cerebrovascular Circulation; Female | 2006 |
The role of infection and inflammation in the pathogenesis of hepatic encephalopathy and cerebral edema in acute liver failure.
Topics: Ammonia; Animals; Brain Edema; Cytokines; Hepatic Encephalopathy; Humans; Infections; Inflammation; | 2006 |
Molecular adsorbent recirculating system (MARS) application in liver failure: clinical and hemodepurative results in 22 patients.
Topics: Acute Kidney Injury; Adult; Aged; Ammonia; Bilirubin; Blood Pressure; Chenodeoxycholic Acid; Cholic | 2006 |
Noncirrhotic portal vein thrombosis exhibits neuropsychological and MR changes consistent with minimal hepatic encephalopathy.
Topics: Administration, Oral; Adult; Ammonia; Attention; Body Water; Brain; Case-Control Studies; Female; Gl | 2006 |
Hepatic encephalopathy with status epileptics: a case report.
Topics: Amino Acids, Branched-Chain; Ammonia; Brain; Electroencephalography; Hepatic Encephalopathy; Humans; | 2006 |
Phosphate-activated glutaminase activity is enhanced in brain, intestine and kidneys of rats following portacaval anastomosis.
Topics: Ammonia; Animals; Basal Ganglia; Cerebral Cortex; Disease Models, Animal; Duodenum; Glutaminase; Hep | 2006 |
Spike-wave stupor in a patient with metabolic encephalopathy.
Topics: Ammonia; Anticonvulsants; Brain Diseases, Metabolic; Coma; Diagnosis, Differential; Diazepam; Electr | 2007 |
Molecular adsorbent recirculating system treatment for patients with liver failure: the Hong Kong experience.
Topics: Adult; Aged; Ammonia; Bilirubin; Blood Urea Nitrogen; Female; Hepatectomy; Hepatic Encephalopathy; H | 2006 |
Surgical shunt closure via the lumen of an intrahepatic portal aneurysm.
Topics: Aged; Ammonia; Aneurysm; Female; Hepatic Encephalopathy; Hepatic Veins; Humans; Portal Vein; Tomogra | 2006 |
[The effects of Helicobacter pylori infection on hyperammonaemia and hepatic encephalopathy in cirrhotic patients].
Topics: Adult; Aged; Ammonia; Female; Helicobacter Infections; Helicobacter pylori; Hepatic Encephalopathy; | 2006 |
Hepatic encephalopathy following transjugular intrahepatic portosystemic shunt (TIPS): management with L-ornithine-L-aspartate and stent reduction.
Topics: Aged; Ammonia; Dipeptides; Hepatic Encephalopathy; Humans; Liver Diseases, Alcoholic; Liver Transpla | 2007 |
Co-administration of C-Phycocyanin ameliorates thioacetamide-induced hepatic encephalopathy in Wistar rats.
Topics: Albumins; Ammonia; Animals; Antioxidants; Brain; Dose-Response Relationship, Drug; Drug Interactions | 2007 |
Methimazole alleviates hepatic encephalopathy in bile-duct ligated cirrhotic rats.
Topics: Alanine Transaminase; Ammonia; Animals; Antithyroid Agents; Bile Ducts; Blood Pressure; Heart Rate; | 2006 |
Protective effects of Gingko biloba on thioacetamide-induced fulminant hepatic failure in rats.
Topics: Acetylcysteine; Alanine Transaminase; Ammonia; Animals; Aspartate Aminotransferases; Bilirubin; Chem | 2006 |
Hypoosmotic swelling and ammonia increase oxidative stress by NADPH oxidase in cultured astrocytes and vital brain slices.
Topics: Ammonia; Animals; Animals, Newborn; Astrocytes; Brain; Brain Edema; Cells, Cultured; Enzyme Inhibito | 2007 |
[Hepatic encephalopathy. The Danish Society of Hepatology].
Topics: Ammonia; Blood-Brain Barrier; Brain; Hepatic Encephalopathy; Humans; Liver Cirrhosis | 2007 |
Critical flicker frequency: diagnostic tool for minimal hepatic encephalopathy.
Topics: Adult; Ammonia; Event-Related Potentials, P300; Female; Flicker Fusion; Hepatic Encephalopathy; Huma | 2007 |
L-Ornithine phenylacetate (OP): a novel treatment for hyperammonemia and hepatic encephalopathy.
Topics: Ammonia; Drug Therapy, Combination; Hepatic Encephalopathy; Humans; Hyperammonemia; Liver; Models, B | 2007 |
Simvastatin for rats with thioacetamide-induced liver failure and encephalopathy.
Topics: Alanine Transaminase; Ammonia; Animals; Aspartate Aminotransferases; Bilirubin; Disease Models, Anim | 2008 |
Inflammation and hepatic encephalopathy: ibuprofen restores learning ability in rats with portacaval shunts.
Topics: Ammonia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclic GMP; Hepatic Encephalopathy; Ibupr | 2007 |
Correlations between magnetic resonance spectroscopy alterations and cerebral ammonia and glucose metabolism in cirrhotic patients with and without hepatic encephalopathy.
Topics: Adult; Aged; Ammonia; Brain; Brain Mapping; Female; Glucose; Hepatic Encephalopathy; Humans; Liver C | 2007 |
Ammonia and inflammation in the pathogenesis of hepatic encephalopathy: Pandora's box?
Topics: Ammonia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclic GMP; Cytokines; Hepatic Encephalop | 2007 |
Non-convulsive status epilepticus secondary to valproic acid-induced hyperammonemic encephalopathy.
Topics: Adult; Ammonia; Anticonvulsants; Brain; Electroencephalography; Hepatic Encephalopathy; Humans; Hype | 2007 |
Balloon-occluded retrograde transvenous obliteration in a patient with hyperammonemic encephalopathy after living donor liver transplantation.
Topics: Adult; Ammonia; Arteriovenous Fistula; Balloon Occlusion; Bile Acids and Salts; Biliary Atresia; Fem | 2007 |
Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure.
Topics: Adult; Aged; Ammonia; Brain Edema; Female; Hepatic Encephalopathy; Humans; Intracranial Hypertension | 2007 |
Controversies in ammonia metabolism: implications for hepatic encephalopathy.
Topics: Ammonia; Animals; Brain; Cerebrovascular Circulation; Hepatic Encephalopathy; Humans | 2007 |
Effect of ammonia, glutamine, and serum on calcineurin, p38MAPK-diP, GADD153/CHOP10, and CNTF in primary rat astrocyte cultures.
Topics: Ammonia; Animals; Astrocytes; Blood Proteins; Brain; Calcineurin; Cells, Cultured; Ciliary Neurotrop | 2007 |
Brain cytokine flux in acute liver failure and its relationship with intracranial hypertension.
Topics: Adult; Ammonia; Brain; Cross-Sectional Studies; Cytokines; Hepatic Encephalopathy; Humans; Interleuk | 2007 |
Malnutrition and diabetes mellitus are related to hepatic encephalopathy in patients with liver cirrhosis.
Topics: Adult; Aged; Ammonia; Diabetes Mellitus; Female; Hepatic Encephalopathy; Humans; Insulin Resistance; | 2007 |
[Role of zinc deficiency in development of hepatic encephalopathy in patients with liver cyrrosis].
Topics: Adult; Aged; Ammonia; Evoked Potentials, Visual; Female; Hepatic Encephalopathy; Humans; Liver Cirrh | 2007 |
Successful occlusion of spontaneous portosystemic shunts leading to encephalopathy in a non-cirrhotic patient by using the Amplatzer vascular plug.
Topics: Ammonia; Balloon Occlusion; Diagnosis, Differential; Female; Hepatic Encephalopathy; Humans; Middle | 2007 |
[A case of hepatic encephalopathy successfully treated by antegrade glycerin enema through percutaneous endoscopic cecostomy].
Topics: Aged; Ammonia; Cecostomy; Constipation; Endoscopy, Gastrointestinal; Enema; Glycerol; Hepatic Enceph | 2008 |
Ammonia inhibits the C-type natriuretic peptide-dependent cyclic GMP synthesis and calcium accumulation in a rat brain endothelial cell line.
Topics: Ammonia; Aniline Compounds; Animals; Binding Sites; Binding, Competitive; Calcium; Calcium Channel B | 2008 |
[Confusion and abnormal liver enzyme levels: problems with diagnosing hepatic encephalopathy].
Topics: Adult; Aged; Ammonia; Confusion; Diagnosis, Differential; Electroencephalography; Fatal Outcome; Fem | 2007 |
Blood ammonia level in liver cirrhosis: a conditio sine qua non to confirm hepatic encephalopathy?
Topics: Ammonia; Biomarkers; Germany; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Professional Practice | 2008 |
Amino acids mixtures in prevention of acute ammonia intoxication in dogs.
Topics: Ammonia; Animals; Aspartic Acid; Blood Urea Nitrogen; Dogs; Hepatic Encephalopathy; Ornithine; Porta | 1967 |
Immune inhibition of urea breakdown in patients with cirrhosis.
Topics: Ammonia; Dietary Proteins; Hemagglutination Tests; Hepatic Encephalopathy; Humans; Immunization; Liv | 1967 |
[Fetal hepatic coma after ureterocolonic anastomosis].
Topics: Alkalosis; Ammonia; Female; Hepatic Encephalopathy; Humans; Middle Aged; Urinary Diversion | 1967 |
Adenosine deaminase activity in liver diseases.
Topics: Aminohydrolases; Ammonia; Hepatic Encephalopathy; Hepatitis; Humans; Liver Cirrhosis; Statistics as | 1967 |
Portal hypertension and hepatic coma.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Hypertension, Portal | 1967 |
[Critical study of venous blood ammonia in hepatic coma. Diagnosis, surveillance and treatment].
Topics: Adult; Aged; Ammonia; Female; Hepatic Encephalopathy; Humans; Male; Middle Aged; Ornithine | 1967 |
Direct transhepatic cross-circulation in hepatic coma in man.
Topics: Ammonia; Bilirubin; Blood Platelets; Blood Transfusion; Female; Femoral Vein; Hematocrit; Hepatic En | 1967 |
Toxins in hepatic encephalopathy: the role of the synergistic effect of ammonia, mercaptans and short chain fatty acids.
Topics: Ammonia; Animals; Caprylates; Drug Synergism; Hepatic Encephalopathy; Kinetics; Rats; Receptors, GAB | 1984 |
The role of amino acids in hepatic encephalopathy.
Topics: Amino Acids; Ammonia; Animals; Biological Transport; Brain; Fatty Acids, Volatile; Hepatic Encephalo | 1980 |
When liver disease causes brain damage.
Topics: Amino Acids; Ammonia; Brain Injuries; Hepatic Encephalopathy; Humans; Medical History Taking; Neurot | 1980 |
Hepatic encephalopathy.
Topics: Amino Acids; Ammonia; Bromocriptine; Constipation; Dietary Proteins; Gastrointestinal Hemorrhage; He | 1981 |
Hepatic encephalopathy and GABA.
Topics: Ammonia; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Neural Inhibition | 1982 |
[Problems of protein supply in patients with liver cirrhosis].
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Methionine; Neurotransmitter Agents; Paren | 1982 |
Diet and hepatic encephalopathy.
Topics: Ammonia; Dietary Proteins; Hepatic Encephalopathy; Humans; Nitrogen; Plant Proteins, Dietary | 1983 |
The enigma of hepatic encephalopathy.
Topics: Adult; Ammonia; Animals; Child; Evoked Potentials, Visual; gamma-Aminobutyric Acid; Hepatic Encephal | 1983 |
Ammonia metabolism in the CNS.
Topics: Acyltransferases; Amidohydrolases; Ammonia; Animals; Asparaginase; Brain; Cats; Central Nervous Syst | 1983 |
[Thioacetamide-induced hepatic encephalopathy in the rat. III Ammonia level and its metabolic substrates in the brain].
Topics: Acetamides; Ammonia; Animals; Brain; Female; Glutamates; Glutamic Acid; Glutamine; Hepatic Encephalo | 1983 |
Hepatic encephalopathy: GABA or ammonia?
Topics: Ammonia; Animals; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Liver | 1984 |
Amino acid, ammonia and neurotransmitter concentrations in hepatic encephalopathy: serial analysis in plasma and cerebrospinal fluid during treatment with an adapted amino acid solution.
Topics: Adult; Aged; Amino Acids; Ammonia; Female; Hepatic Encephalopathy; Humans; Infusions, Parenteral; Ma | 1984 |
Glutamic acid and glutamine levels in serum and cerebrospinal fluid in hepatic encephalopathy.
Topics: Adult; Aged; Ammonia; Female; Glutamates; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Hepatiti | 1984 |
[Pathogenesis of hepatic encephalopathy--studies in the rabbit model of acute liver failure].
Topics: Ammonia; Animals; Arousal; Brain; Disease Models, Animal; Electroencephalography; Evoked Potentials, | 1984 |
Oral and parenteral nutrition with L-Valine: mode of action.
Topics: Aged; Ammonia; Brain; Female; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid; Male; Middle | 1980 |
Relationship between plasma and brain tryptophan in pigs during experimental hepatic coma before and after hemodialysis with selective membranes.
Topics: Acrylic Resins; Acrylonitrile; Amino Acids; Ammonia; Animals; Brain; Cellulose; Copper; Hepatic Ence | 1981 |
Infusion of branched-chain enriched amino acid solution in patients with hepatic encephalopathy.
Topics: 2-Hydroxyphenethylamine; Aged; Amino Acids; Amino Acids, Branched-Chain; Ammonia; Chronic Disease; F | 1982 |
[Evaluation of peripheral and CNS biochemical changes in models of acute and chronic experimental hepatic insufficiency in the rat].
Topics: Amino Acids; Ammonia; Animals; Brain Chemistry; Cholecystokinin; Hepatic Encephalopathy; Liver Disea | 1983 |
Respective roles of ammonia, amino acids, and medium-sized molecules in the pathogenesis of experimentally induced acute hepatic encephalopathy.
Topics: Amino Acids; Ammonia; Animals; Brain; Cerebral Cortex; Dopamine; Hepatic Encephalopathy; Ischemia; L | 1983 |
Visual evoked potential: a diagnostic tool for the assessment of hepatic encephalopathy.
Topics: Adult; Amino Acids, Essential; Ammonia; Electroencephalography; Evoked Potentials, Visual; Female; H | 1984 |
Ammonia intoxication in hepatic coma.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver Diseases | 1984 |
Encephalopathy, oxygen consumption, visceral amino acid clearance, and mortality in cirrhotic surgical patients.
Topics: Adult; Aged; Amino Acids; Amino Acids, Branched-Chain; Ammonia; Female; Hemodynamics; Hepatic Enceph | 1984 |
Brain carbonic anhydrase activity in rats in experimental hepatogenic encephalopathy.
Topics: Ammonia; Animals; Brain; Carbonic Anhydrases; Female; Hepatic Encephalopathy; Rats; Rats, Inbred Str | 1984 |
[The level of ammonia and its metabolites in the brain in experimental hepatic encephalopathy induced by long-term administration of thioacetamine and during recovery].
Topics: Ammonia; Animals; Brain; Female; Glutamine; Hepatic Encephalopathy; Ketoglutaric Acids; Rats; Rats, | 1984 |
Brain methanethiol and ammonia concentrations in experimental hepatic coma and coma induced by injections of various combinations of these substances.
Topics: Ammonia; Ammonium Chloride; Animals; Brain Chemistry; Caprylates; Coma; Dose-Response Relationship, | 1984 |
Grade I Reye's syndrome--outcome and predictors of progression to deeper coma grades.
Topics: Ammonia; Child; Female; Hepatic Encephalopathy; Humans; Liver; Male; Prognosis; Prothrombin Time; Re | 1984 |
[A case of adult-type citrullinemia].
Topics: Adult; Amino Acids; Ammonia; Citrulline; Hepatic Encephalopathy; Humans; Male | 1984 |
Large-pore hemodialytic procedures in pigs with ischemic hepatic necrosis; a randomized study.
Topics: Ammonia; Animals; Blood; Disease Models, Animal; Electroencephalography; Hepatic Encephalopathy; Isc | 1984 |
[Hepatic coma. Basic principles of pathogenesis and treatment. 1. Pathogenesis].
Topics: Amino Acids; Ammonia; Brain; Diuretics; Endotoxins; Gastrointestinal Hemorrhage; Hepatic Encephalopa | 1983 |
[Intrahepatic portal arterialization associated with portacaval shunt: a preliminary experimental report].
Topics: Amino Acids; Ammonia; Animals; Dogs; Hepatic Encephalopathy; Liver; Portacaval Shunt, Surgical; Port | 1983 |
Erythrocyte ammonia in liver disease.
Topics: Adolescent; Adsorption; Adult; Ammonia; Blood Specimen Collection; Erythrocytes; Female; Hepatic Enc | 1983 |
Visual evoked potentials in a rabbit model of hepatic encephalopathy. II. Comparison of hyperammonemic encephalopathy, postictal coma, and coma induced by synergistic neurotoxins.
Topics: Ammonia; Animals; Caprylates; Disease Models, Animal; Disulfides; Evoked Potentials, Visual; Galacto | 1984 |
Blood and brain concentrations of mercaptans in hepatic and methanethiol induced coma.
Topics: Ammonia; Animals; Brain Chemistry; Coma; Hepatic Encephalopathy; Humans; Liver Diseases; Methionine; | 1984 |
Quantitative psychometric testing and subclinical hepatic encephalopathy--comparative study between encephalopathic and non-encephalopathic patients with liver cirrhosis.
Topics: Adult; Age Factors; Aged; Alcoholism; Ammonia; Female; Hepatic Encephalopathy; Humans; Liver Cirrhos | 1984 |
[Parenteral feeding of patients with liver cirrhosis with hepatic encephalopathy].
Topics: Amino Acids; Ammonia; Arginine; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Ornithine; Parenter | 1980 |
Plasma levels of false neurotransmitters across the brain in portal-systemic encephalopathy.
Topics: 2-Hydroxyphenethylamine; Amino Acids; Amino Acids, Branched-Chain; Ammonia; Brain Chemistry; Glutami | 1982 |
Management of acute portal systemic encephalopathy.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Syndrome | 1982 |
Ammonia intoxication in portal systemic encephalopathy.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Portal System | 1982 |
[Sodium valproate, hyperammonemia and hepatic encephalopathy].
Topics: Ammonia; Hepatic Encephalopathy; Humans; Valproic Acid | 1982 |
The brain in experimental portal-systemic encephalopathy. I. Morphological changes in three animal models.
Topics: Ammonia; Animals; Astrocytes; Brain; Carbon Tetrachloride Poisoning; Cation Exchange Resins; Cerebel | 1983 |
The brain in experimental portal-systemic encephalopathy. II. Water and electrolyte changes.
Topics: Ammonia; Animals; Blood Proteins; Body Water; Brain; Cation Exchange Resins; Chlorides; Disease Mode | 1983 |
Potential toxins of acute liver failure and their effects on blood-brain barrier permeability.
Topics: Ammonia; Animals; Bilirubin; Blood-Brain Barrier; Brain; Fatty Acids, Nonesterified; Hepatic Encepha | 1983 |
Hepatic function--3: protein metabolism and blood ammonia tests.
Topics: Ammonia; Animals; Blood Proteins; Dog Diseases; Dogs; Hepatic Encephalopathy; Liver; Liver Diseases; | 1981 |
The permeability of the blood-brain barrier and cell membranes to horseradish peroxidase in hyperammonaemia.
Topics: Ammonia; Animals; Blood-Brain Barrier; Cell Membrane Permeability; Endothelium; Hepatic Encephalopat | 1981 |
Ammonia-induced changes in pancreatic hormones and plasma amino acids in patients with liver cirrhosis.
Topics: Adult; Aged; Amino Acids; Ammonia; Ammonium Chloride; Blood Glucose; Female; Glucagon; Hepatic Encep | 1982 |
[Hepatic encephalopathy].
Topics: Amino Acids; Ammonia; Brain; Hepatic Encephalopathy; Humans; Levodopa; Liver Cirrhosis | 1980 |
Ammonia intoxication: energy metabolism and brain protein synthesis.
Topics: Adenosine Triphosphate; Ammonia; Animals; Brain; Brain Chemistry; Energy Metabolism; Guanosine Triph | 1982 |
Induction of coma in normal dogs by the infusion of aromatic amino acids and its prevention by the addition of branched-chain amino acids.
Topics: Amino Acids, Branched-Chain; Ammonia; Animals; Biological Transport; Blood-Brain Barrier; Brain; Com | 1982 |
Impaired metabolism of methionine in severe liver diseases. II. Clinical and experimental studies on role of impaired methionine metabolism in pathogenesis of hepatic encephalopathy.
Topics: Ammonia; Animals; Brain; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hepatic Enc | 1982 |
[Continuous haemofiltration in encephalopathy associated with hepatic failure (author's transl)].
Topics: Amino Acids; Ammonia; Blood; Hepatic Encephalopathy; Hepatitis; Humans; Liver Cirrhosis, Alcoholic; | 1982 |
Cerebral vessels and glial cells in liver disease. A morphometric and electron microscopic investigation.
Topics: Ammonia; Animals; Astrocytes; Blood Vessels; Cerebrovascular Circulation; Hepatic Encephalopathy; Hu | 1982 |
Arterial and venous ammonia concentrations in the diagnosis of canine hepato-encephalopathy.
Topics: Ammonia; Animals; Arteries; Dog Diseases; Dogs; Female; Hepatic Encephalopathy; Liver Circulation; M | 1982 |
Rectal ammonia tolerance test in the evaluation of portal circulation in dogs with liver disease.
Topics: Ammonia; Ammonium Chloride; Animals; Collateral Circulation; Dog Diseases; Dogs; Female; Hepatic Enc | 1982 |
[Therapy of hepatic encephalopathy. Changes in the cerebrospinal fluid concentration of catecholamine neurotransmitters, ammonia and amino acids in the course of an infusion treatment with branched-chain amino acids].
Topics: Amino Acids; Amino Acids, Branched-Chain; Ammonia; Brain; Catecholamines; Dopamine; Epinephrine; Hep | 1982 |
[Electroencephalography and cerebrospinal fluid glutamine in portal-systemic encephalopathies].
Topics: Adult; Aged; Ammonia; Electroencephalography; Female; Glutamine; Hepatic Encephalopathy; Humans; Mal | 1982 |
[Antagonism of the ammonia effect on serotonin receptors by L-valine].
Topics: Aged; Ammonia; Female; Frontal Lobe; Hepatic Encephalopathy; Humans; Kinetics; Male; Middle Aged; Re | 1982 |
Plasma alpha-ketoglutarate in urea cycle enzymopathies and its role as a harbinger of hyperammonemic coma.
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Argininosuccinate Synthase; Argini | 1980 |
Effect of colectomy upon ammonemia and glutaminemia in rats with stricture of the portal vein.
Topics: Ammonia; Animals; Colectomy; Constriction, Pathologic; Glutamine; Hepatic Encephalopathy; Male; Port | 1981 |
Blood mercaptan and ammonia concentrations in cirrhotics after a protein load.
Topics: Adult; Ammonia; Dietary Proteins; Hepatic Encephalopathy; Humans; Liver Cirrhosis, Alcoholic; Male; | 1980 |
[Hepatic coma - experimental study with swine (part 1)].
Topics: Acetamides; Ammonia; Animals; Creatinine; Disease Models, Animal; Electrolytes; Enzymes; Female; Hep | 1981 |
[Assessment of the course of chronic hepatic encephalopathy. Comparison of various measurements with special reference to the trail-making test].
Topics: Aged; Ammonia; Chronic Disease; Electroencephalography; Female; Hepatic Encephalopathy; Humans; Live | 1981 |
Hyperammonemic, ammonia-independent coma in experimental acute liver failure induced in the pig.
Topics: Ammonia; Animals; Hepatic Encephalopathy; Swine | 1981 |
Chronic refractory encephalopathy. Evaluation of an ileostomy 22 years after portacaval shunt.
Topics: Amino Acids; Ammonia; Biotransformation; Colon; Electroencephalography; Hepatic Encephalopathy; Huma | 1981 |
[The role of methyl mercaptan and dimethyl sulfide in the expired alveolar gas in patients with hepatic coma (author's transl)].
Topics: Adult; Aged; Ammonia; Breath Tests; Female; Hepatic Encephalopathy; Humans; Male; Middle Aged; Pulmo | 1981 |
Haemoperfusion through activated charcoal in dogs with fulminant liver failure.
Topics: Ammonia; Animals; Bilirubin; Blood Chemical Analysis; Charcoal; Dogs; Hemoperfusion; Hepatic Encepha | 1980 |
Toxic encephalopathy with hyperammonaemia during high-dose salicylate therapy.
Topics: Adolescent; Ammonia; Chemical and Drug Induced Liver Injury; Child; Electroencephalography; Female; | 1980 |
Prevalence of subclinical hepatic encephalopathy in cirrhotics and relationship to plasma amino acid imbalance.
Topics: Adult; Aged; Amino Acids; Amino Acids, Branched-Chain; Ammonia; Blood-Brain Barrier; Female; Hepatic | 1980 |
Blood methanethiol in alcoholic liver disease with and without hepatic encephalopathy.
Topics: Adult; Aged; Ammonia; Female; Hepatic Encephalopathy; Humans; Liver Diseases, Alcoholic; Male; Middl | 1980 |
Hippocampal glutamate release after porta cava anastomosis: reduced sensitivity to ammonia inhibition.
Topics: Ammonia; Ammonium Chloride; Animals; Female; Glutamates; Glutaminase; Hepatic Encephalopathy; Hippoc | 1980 |
Hepatic encephalopathy: a unifying hypothesis.
Topics: Ammonia; Glutamine; Hepatic Encephalopathy; Humans; Tryptophan | 1980 |
Blood-brain barrier derangement in sepsis: cause of septic encephalopathy?
Topics: Abdomen; Amino Acids; Ammonia; Animals; Biological Transport; Blood Glucose; Blood-Brain Barrier; Br | 1981 |
Depressed uptake of serotonin by platelets in hepatic encephalopathy.
Topics: Amines; Ammonia; Bile Acids and Salts; Bilirubin; Blood Platelets; Hepatic Encephalopathy; Humans; P | 1980 |
[Behaviour of ammonemia during treatment of chronic/hyperammonemic hepatopathy with S-adenosyl-L-methionine].
Topics: Adult; Aged; Ammonia; Chronic Disease; Female; Hepatic Encephalopathy; Humans; Liver Diseases; Male; | 1980 |
[Porto-caval encephalopathy (author's transl)].
Topics: Ammonia; Hepatic Encephalopathy; Humans; Hypertension, Portal; Portacaval Shunt, Surgical | 1980 |
Astrocyte swelling in liver failure: role of glutamine and benzodiazepines.
Topics: Ammonia; Animals; Animals, Newborn; Astrocytes; Brain Edema; Cells, Cultured; Cerebral Cortex; Chlor | 1994 |
Neocortical dialysate monoamines of rats after acute, subacute, and chronic liver shunt.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acute Disease; Amino Acids; Ammonia; Animals; Biogenic Monoamines; B | 1995 |
Patent ductus venosus associated with a hyperintense globus pallidum on T1-weighted magnetic resonance imaging and pulmonary hypertension.
Topics: Adolescent; Ammonia; Globus Pallidus; Hepatic Encephalopathy; Humans; Hypertension, Pulmonary; Liver | 1995 |
Hyperammonaemia in cirrhosis and Helicobacter pylori infection.
Topics: Ammonia; Anti-Bacterial Agents; Breath Tests; Female; Helicobacter Infections; Helicobacter pylori; | 1995 |
Determination of ammonia in ear-lobe capillary blood is an alternative to arterial blood ammonia.
Topics: Adolescent; Adult; Aged; Ammonia; Arteries; Capillaries; Ear; Female; Hepatic Encephalopathy; Humans | 1995 |
Hyperammonaemia and Helicobacter pylori.
Topics: Ammonia; Female; Helicobacter pylori; Hepatic Encephalopathy; Hepatitis C; Humans; Liver Cirrhosis; | 1995 |
[The effect of lactitol (NS-4) on the concentrations of ammonia and amino acids in blood and cerebrospinal fluid in Eck fistula (portacaval-shunted) dogs].
Topics: Amino Acids; Ammonia; Animals; Disease Models, Animal; Dogs; Hepatic Encephalopathy; Lactulose; Male | 1995 |
[Effects of lactitol on fecal bacterial flora in patients with liver cirrhosis and hepatic encephalopathy].
Topics: Aged; Ammonia; Bacteria; Feces; Female; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Male; Middl | 1995 |
L-glutamate and gamma-aminobutyric acid uptake in synaptosomes from the cerebral cortex of dogs with congenital chronic hepatic encephalopathy.
Topics: Ammonia; Animals; Cerebral Cortex; Chronic Disease; Dogs; gamma-Aminobutyric Acid; Glutamic Acid; He | 1995 |
Factors associated with severe intracranial hypertension in candidates for emergency liver transplantation.
Topics: Adult; Alanine Transaminase; alpha-Fetoproteins; Ammonia; Bilirubin; Brain Injuries; Contraindicatio | 1993 |
[Anesthetic management for a patient with citrullinemia and liver cirrhosis].
Topics: Ammonia; Anesthesia, Spinal; Benzoates; Benzoic Acid; Citrulline; Female; Femoral Neck Fractures; He | 1995 |
[Effect of lactitol (NS-4) on the increase in blood and brain ammonia concentration and on coma in newly developed rat models of hepatic coma].
Topics: Ammonia; Animals; Brain; Disease Models, Animal; Hepatic Encephalopathy; Lactulose; Male; Rats; Rats | 1995 |
Hepatic encephalopathy, hyperammonemia, and ammonia toxicity. Papers presented at the International Symposium on Cirrhosis, Hyperammonemia and hepatic encephalopathy. Valencia, Spain, January 24-27, 1994.
Topics: Ammonia; Animals; Hepatic Encephalopathy; Humans; Liver Cirrhosis | 1994 |
Acute cerebral edema as part of the syndrome of hepatic encephalopathy in an individual with chronic liver disease: a case report.
Topics: Acute Disease; Adult; Ammonia; Brain Edema; Chronic Disease; Fatal Outcome; Hepatic Encephalopathy; | 1994 |
[Ammonia determination in hepatic encephalopathy].
Topics: Ammonia; Diagnosis, Differential; Hepatic Encephalopathy; Humans | 1995 |
Cirrhosis, Hyperammonemia and Hepatic Encephalopathy. Proceedings of a meeting. Spain, August 10-14, 1992.
Topics: Ammonia; Animals; Hepatic Encephalopathy; Humans; Liver Cirrhosis | 1993 |
Intestinal glutamine and ammonia metabolism during chronic hyperammonaemia induced by liver insufficiency.
Topics: Alanine; Ammonia; Animals; Bile Ducts; Blood Flow Velocity; Body Weight; Chronic Disease; Citrulline | 1993 |
Region-selective reductions in activities of glutamine synthetase in rat brain following portacaval anastomosis.
Topics: Ammonia; Animals; Brain; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Hepatic Encephalopathy; | 1993 |
Extracellular brain glutamate during acute liver failure and during acute hyperammonemia simulating acute liver failure: an experimental study based on in vivo brain dialysis.
Topics: Ammonia; Animals; Brain; Electroencephalography; Extracellular Space; Glutamates; Glutamic Acid; Hep | 1994 |
Human fetal hepatocyte transplantation in patients with fulminant hepatic failure.
Topics: Adult; Ammonia; Bilirubin; Child; Female; Fetal Tissue Transplantation; Hepatic Encephalopathy; Hepa | 1994 |
Effects of high-normal and low-normal serum potassium levels on hepatic encephalopathy: facts, half-facts or artifacts?
Topics: Amino Acids, Branched-Chain; Ammonia; Artifacts; Furosemide; Hepatic Encephalopathy; Humans; Potassi | 1994 |
45CaCl2 autoradiography in brain from rabbits with encephalopathy from acute liver failure or acute hyperammonemia.
Topics: Acetates; Ammonia; Animals; Autoradiography; Blood Glucose; Brain; Brain Diseases; Calcium; Calcium | 1994 |
8th International Symposium on Ammonia. Advances in Hepatic Encephalopathy and Metabolic Nitrogen Exchange. Italy, May 6-9, 1993. Abstracts.
Topics: Ammonia; Animals; Hepatic Encephalopathy; Humans; Nitrogen | 1993 |
Hyperammonemia and hepatic encephalopathy stimulate rat cerebral synaptic mitochondrial glutamate dehydrogenase activity specifically in the direction of glutamate oxidation.
Topics: Ammonia; Animals; Brain; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Hepatic Encephalopathy; | 1993 |
The importance of the highest normokalemia in the treatment of early hepatic encephalopathy.
Topics: Adult; Aged; Ammonia; Cause of Death; Electroencephalography; Female; Hepatic Encephalopathy; Humans | 1993 |
Reversal of behavioral changes in rats subjected to portacaval shunt with oral neomycin therapy.
Topics: Ammonia; Animals; Behavior, Animal; Blood Urea Nitrogen; Disease Models, Animal; Hepatic Encephalopa | 1994 |
Encephalopathy from acute liver failure and from acute hyperammonemia in the rabbit. A clinical and biochemical study.
Topics: Ammonia; Animals; Brain Edema; Disease Models, Animal; Electroencephalography; Hepatic Encephalopath | 1994 |
Astrocytes and the entry of circulating ammonia into the brain: effect of fluoroacetate.
Topics: Ammonia; Animals; Astrocytes; Brain; Carotid Artery, Common; Chromatography, High Pressure Liquid; E | 1993 |
[A case of severe malnutrition fatty liver due to portacaval shunt].
Topics: Aged; Ammonia; Fatty Liver; Female; Hepatic Encephalopathy; Humans; Mesenteric Veins; Nutrition Diso | 1993 |
Brain ion and amino acid contents during edema development in hepatic encephalopathy.
Topics: Acetates; Alanine Transaminase; Amino Acids; Ammonia; Animals; Aspartate Aminotransferases; Blood Pr | 1994 |
Gastrointestinal transit in cirrhotic patients: effect of hepatic encephalopathy and its treatment.
Topics: Adult; Ammonia; Chronic Disease; Dietary Proteins; Female; Gastric Emptying; Gastrointestinal Transi | 1994 |
Gender-dependent reduction of spontaneous motor activity and growth in rats subjected to portacaval shunt.
Topics: Amino Acids; Ammonia; Animals; Body Weight; Disease Models, Animal; Eating; Female; Hepatic Encephal | 1994 |
Portal-systemic encephalopathy and hypothalamic hypothyroidism: effect of thyroid hormone on ammonia metabolism.
Topics: Ammonia; Euthyroid Sick Syndromes; Female; Hepatic Encephalopathy; Humans; Hypothalamic Diseases; Hy | 1993 |
[A case of portal-systemic shunt with progressive ataxia].
Topics: Aged; Ammonia; Ataxia; Hepatic Encephalopathy; Humans; Male; Portal Vein | 1993 |
Neuronal and glial marker proteins in encephalopathy associated with acute liver failure and acute hyperammonemia in the rabbit.
Topics: Acute Disease; Ammonia; Animals; Hepatic Encephalopathy; Intermediate Filaments; Liver Failure; Nerv | 1993 |
Binding of the ligand [3H]MK-801 to the MK-801 binding site of the N-methyl-D-aspartate receptor during experimental encephalopathy from acute liver failure and from acute hyperammonemia in the rabbit.
Topics: Acute Disease; Ammonia; Animals; Binding Sites; Dizocilpine Maleate; Hepatic Encephalopathy; Liver F | 1993 |
The action of ammonia on astrocyte glycogen and glycogenolysis.
Topics: Ammonia; Animals; Astrocytes; Cells, Cultured; Glycogen; Hepatic Encephalopathy; Norepinephrine; Rat | 1993 |
[A case of hyperammonemia in chronic renal failure successfully treated with the infusion of NaHCO3].
Topics: Acid-Base Equilibrium; Acidosis; Aged; Ammonia; Female; Hepatic Encephalopathy; Humans; Infusions, I | 1993 |
The two catalytic components of the 2-oxoglutarate dehydrogenase complex in rat cerebral synaptic and nonsynaptic mitochondria: comparison of the response to in vitro treatment with ammonia, hyperammonemia, and hepatic encephalopathy.
Topics: Acetates; Ammonia; Animals; Brain; Catalysis; Hepatic Encephalopathy; In Vitro Techniques; Ketogluta | 1993 |
Reduction of increased signal intensity in the basal ganglia on T1-weighted MR images during treatment of hepatic encephalopathy.
Topics: Ammonia; Basal Ganglia; Hepatic Encephalopathy; Humans; Magnetic Resonance Imaging; Male; Middle Age | 1993 |
Changes in the cytoplasmic (lactate dehydrogenase) and plasma membrane (acetylcholinesterase) marker enzymes in the synaptic and nonsynaptic mitochondria derived from rats with moderate hyperammonemia.
Topics: Acetylcholinesterase; Ammonia; Animals; Biomarkers; Cell Membrane; Chemical Phenomena; Chemistry, Ph | 1993 |
Metabolic aspects of cultured hepatocytes for use in a bioartificial liver support system.
Topics: Ammonia; Animals; Artificial Organs; Blood Proteins; Capsules; Cells, Cultured; Culture Media; Fibri | 1995 |
[Hepatic encephalopathy].
Topics: Ammonia; Hepatic Encephalopathy; Humans; Neurologic Examination; Neuropsychological Tests; Prognosis | 1995 |
Zinc supplementation and amino acid-nitrogen metabolism in patients with advanced cirrhosis.
Topics: Administration, Oral; Adult; Aged; Alanine; Ammonia; Female; Glucagon; Hepatic Encephalopathy; Human | 1996 |
Auxiliary partial orthotopic liver transplantation from a living related donor: a report of two cases.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Child, Preschool; Fatal Outcome; Fathers; Female; Fol | 1996 |
The effect of oxygen transport resistances on the viability and functions of isolated rat hepatocytes.
Topics: Ammonia; Animals; Artificial Organs; Biological Transport, Active; Cell Separation; Cell Survival; C | 1996 |
Per rectal portal scintigraphy in the diagnosis and management of feline congenital portosystemic shunts.
Topics: Ammonia; Animals; Bile Acids and Salts; Cat Diseases; Cats; Congenital Abnormalities; Female; Hepati | 1996 |
Transient metabolic hyperammonaemia in young Irish wolfhounds.
Topics: Age Factors; Ammonia; Animals; Dog Diseases; Dogs; Female; Hepatic Encephalopathy; Male; Portal Syst | 1996 |
Clinical and pathological studies in horses with hepatic disease.
Topics: Ammonia; Animals; Bile Acids and Salts; Bilirubin; Biopsy; Blood Glucose; Disease Progression; Femal | 1996 |
Magnetic resonance imaging pallidal hypersignal in cirrhotic subjects.
Topics: Ammonia; Globus Pallidus; Hepatic Encephalopathy; Humans; Magnetic Resonance Imaging; Neuropsycholog | 1996 |
Preclinical trial of a bioartificial liver support system in a porcine fulminant hepatic failure model.
Topics: Amino Acids; Ammonia; Animals; Artificial Organs; Extracorporeal Circulation; Fibrinogen; Hepatic En | 1996 |
Synaptosomal and brain slice cerebrocortical [3H]L-glutamate uptake in a rat model of chronic hepatic encephalopathy.
Topics: Ammonia; Animals; Cerebral Cortex; Chronic Disease; Glutamic Acid; Hepatic Encephalopathy; In Vitro | 1996 |
Modulation of ligand binding to components of the GABAA receptor complex by ammonia: implications for the pathogenesis of hyperammonemic syndromes.
Topics: Ammonia; Animals; Flunitrazepam; GABA Agonists; GABA Modulators; Hepatic Encephalopathy; Ligands; Ma | 1996 |
Relation of taurine transport and brain edema in rats with simple hyperammonemia or liver failure.
Topics: Ammonia; Animals; Basal Ganglia; Body Water; Brain Edema; Cerebral Cortex; Hepatic Encephalopathy; I | 1996 |
Arterial ammonia with Blood Ammonia Checker II and with indophenol reaction to assess presence of hepatic encephalopathy.
Topics: Adult; Aged; Ammonia; Brain Diseases; Female; Hepatic Encephalopathy; Humans; Indophenol; Lung Disea | 1996 |
Acute liver failure and hyperammonemia increase peripheral-type benzodiazepine receptor binding and pregnenolone synthesis in mouse brain.
Topics: Acetates; Ammonia; Animals; Brain; Disease Models, Animal; Hepatic Encephalopathy; Liver Failure, Ac | 1995 |
Determinants of ammonia clearance by hemodialysis.
Topics: Ammonia; Blood Flow Velocity; Brain Edema; Dialysis Solutions; Glutamine; Hepatic Encephalopathy; Hu | 1996 |
Case report: recurrent hyperammonaemic encephalopathy due to citrullinaemia in a 52 year old man.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Argininosuccinate Synthase; China; Citrulline; Hepati | 1996 |
Glutamine, myo-inositol, and organic brain osmolytes after portocaval anastomosis in the rat: implications for ammonia-induced brain edema.
Topics: Ammonia; Animals; Blood Pressure; Body Water; Body Weight; Brain; Brain Edema; Cerebral Cortex; Glut | 1996 |
Severity of hyperammonemic encephalopathy correlates with brain ammonia level and saturation of glutamine synthetase in vivo.
Topics: Ammonia; Animals; Brain; Glutamate-Ammonia Ligase; Glutamine; Hepatic Encephalopathy; Kinetics; Male | 1996 |
Comparison of the metabolic disturbances caused by end-to-side and side-to-side portacaval shunts.
Topics: Amino Acids; Ammonia; Animals; Blood Glucose; Body Weight; Brain; Disease Models, Animal; Hepatic En | 1996 |
Ammonia and encephalopathy in the horse.
Topics: Ammonia; Animals; Biomarkers; Hepatic Encephalopathy; Horse Diseases; Horses; Liver; Syndrome | 1997 |
Hyperammonaemia associated with encephalopathy and abdominal pain without evidence of liver disease in four mature horses.
Topics: Abdominal Pain; Ammonia; Animals; Bicarbonates; Bile Acids and Salts; Bilirubin; Biomarkers; Creatin | 1997 |
Protective effect of L-carnitine in ammonia-precipitated encephalopathy in the portacaval shunted rat.
Topics: Amino Acids; Ammonia; Animals; Carnitine; Hepatic Encephalopathy; Lactates; Male; Portasystemic Shun | 1997 |
The effects of ammonia and portal-systemic shunting on brain metabolism, neurotransmission and intracranial hypertension in hyperammonaemia-induced encephalopathy.
Topics: Amino Acids; Ammonia; Animals; Body Water; Brain; Glutamate-Ammonia Ligase; Hepatic Encephalopathy; | 1997 |
Application of immunoapheresis for delaying hyperacute rejection during isolated xenogeneic pig liver perfusion.
Topics: Acute Disease; Ammonia; Animals; Antibodies, Heterophile; Blood Component Removal; Complement C3; Co | 1997 |
Precipitation of overt encephalopathy in the portacaval shunted rat: towards the development of an adequate model of chronic portal systemic encephalopathy.
Topics: Ammonia; Animals; Blood Urea Nitrogen; Body Weight; Disease Models, Animal; Feasibility Studies; Hep | 1997 |
Memantine, a noncompetitive NMDA receptor antagonist improves hyperammonemia-induced encephalopathy and acute hepatic encephalopathy in rats.
Topics: Ammonia; Animals; Body Water; Brain; Disease Models, Animal; Electroencephalography; Glutamic Acid; | 1997 |
Helicobacter pylori, hyperammonemia, and hepatic encephalopathy: is there a correlation?
Topics: Ammonia; Helicobacter Infections; Helicobacter pylori; Hepatic Encephalopathy; Humans; Liver Cirrhos | 1997 |
Helicobacter pylori, ammonia and the brain.
Topics: Ammonia; Helicobacter Infections; Helicobacter pylori; Hepatic Encephalopathy; Humans; Risk Factors | 1997 |
The glial glutamate transporter in hyperammonemia and hepatic encephalopathy: relation to energy metabolism and glutamatergic neurotransmission.
Topics: Amino Acid Transport System X-AG; Ammonia; Animals; Astrocytes; ATP-Binding Cassette Transporters; B | 1997 |
Oral glutamine challenge in cirrhotics pre- and post-liver transplantation: a psychometric and analyzed EEG study.
Topics: Adult; Ammonia; Electroencephalography; Female; Glutamine; Hepatic Encephalopathy; Humans; Liver Cir | 1997 |
Loss and recovery of liver regeneration in rats with fulminant hepatic failure.
Topics: Albumins; Ammonia; Animals; Bilirubin; Cell Division; Cell Transplantation; Disease Models, Animal; | 1997 |
Orthotopic liver transplantation for adult-onset type II citrullinaemia.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids, Branched-Chain; Ammonia; Arginine; Arginin | 1997 |
[A case of von Recklinghausen disease associated with portal hypertension , hyperammonemia and giant portacaval shunt].
Topics: Ammonia; Aneurysm; Female; Hepatic Encephalopathy; Humans; Hypertension, Portal; Middle Aged; Neurof | 1997 |
Changes in endogenous benzodiazepine-like compound levels during the course of fulminant hepatic failure: potential effects of decreased renal function.
Topics: Adult; Ammonia; Benzodiazepines; Female; Hepatic Encephalopathy; Humans | 1997 |
Hypothyroidism minimizes liver damage and improves survival in rats with thioacetamide induced fulminant hepatic failure.
Topics: Ammonia; Animals; Cytokines; Hepatic Encephalopathy; Hypothyroidism; Liver; Male; Malondialdehyde; R | 1998 |
Positive biochemical effects of a bioartificial liver support system (BALSS) in a porcine fulminant hepatic failure (FHF) model.
Topics: Adenosine Triphosphate; Amino Acids; Ammonia; Animals; Bioreactors; Cell Adhesion; Cells, Cultured; | 1998 |
Analysis of risk factors for chronic hepatic encephalopathy: the role of Helicobacter pylori infection.
Topics: Ammonia; Amoxicillin; Anti-Ulcer Agents; Ascites; Chronic Disease; Diuretics; Helicobacter Infection | 1998 |
Benzodiazepines in hepatic encephalopathy: sleeping with the enemy.
Topics: Ammonia; Benzodiazepines; Hepatic Encephalopathy; Humans; Liver Cirrhosis | 1998 |
L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action.
Topics: Ammonia; Animals; Dipeptides; Glutamic Acid; Hepatic Encephalopathy; Male; Portacaval Shunt, Surgica | 1998 |
Portosystemic hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in patients with cirrhosis: clinical, laboratory, psychometric, and electroencephalographic investigations.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ammonia; Electroencephalography; Female; Hemodynamics; H | 1998 |
Improvement of chronic hepatic encephalopathy in dogs by the benzodiazepine-receptor partial inverse agonist sarmazenil, but not by the antagonist flumazenil.
Topics: Ammonia; Animals; Benzodiazepines; Chronic Disease; Disease Models, Animal; Dogs; Electroencephalogr | 1998 |
Chronic hyponatremia exacerbates ammonia-induced brain edema in rats after portacaval anastomosis.
Topics: Ammonia; Animals; Brain; Brain Edema; Chronic Disease; Hepatic Encephalopathy; Hyponatremia; Male; P | 1998 |
Does the extend of the culture time of primary hepatocytes in a bioreactor affect the treatment efficacy of a bioartificial liver?
Topics: Ammonia; Animals; Bioreactors; Cell Culture Techniques; Glutathione Transferase; Hepatic Encephalopa | 1998 |
Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration.
Topics: Acute Disease; Adult; Ammonia; Arteries; Encephalocele; Female; Hepatic Encephalopathy; Humans; Live | 1999 |
Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration.
Topics: Acute Disease; Adult; Ammonia; Arteries; Encephalocele; Female; Hepatic Encephalopathy; Humans; Live | 1999 |
Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration.
Topics: Acute Disease; Adult; Ammonia; Arteries; Encephalocele; Female; Hepatic Encephalopathy; Humans; Live | 1999 |
Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration.
Topics: Acute Disease; Adult; Ammonia; Arteries; Encephalocele; Female; Hepatic Encephalopathy; Humans; Live | 1999 |
Helicobacter pylori, hyperammonemia and subclinical portosystemic encephalopathy: effects of eradication.
Topics: Aged; Ammonia; Anti-Bacterial Agents; Anti-Ulcer Agents; Clarithromycin; Drug Therapy, Combination; | 1999 |
Fast resolution of hypercortisolism in dogs with portosystemic encephalopathy after surgical shunt closure.
Topics: Adrenocortical Hyperfunction; Ammonia; Animals; Bile Acids and Salts; Dog Diseases; Dogs; Female; He | 1999 |
Temporary extracorporeal liver support for severe acute alcoholic hepatitis using the BioLogic-DT.
Topics: Acute Disease; Adult; Ammonia; Biocompatible Materials; Blood Coagulation; Cytokines; Female; Hepati | 1999 |
Chronic hyperammonemia in rats impairs activation of soluble guanylate cyclase in neurons and in lymphocytes: a putative peripheral marker for neurological alterations.
Topics: Ammonia; Animals; Biomarkers; Cells, Cultured; Chronic Disease; Cyclic GMP; Enzyme Activation; Excit | 1999 |
[Pathognomonic significance of increased ammonia levels].
Topics: Ammonia; Chronic Disease; Diabetes Mellitus, Type 2; Diagnosis, Differential; Female; Hepatic Enceph | 1999 |
Molecular adsorbent recycling system (MARS): clinical results of a new membrane-based blood purification system for bioartificial liver support.
Topics: Adsorption; Adult; Ammonia; Bilirubin; Cholinesterases; Creatinine; Female; Hepatic Encephalopathy; | 1999 |
Reversibility of hyperintense globus pallidus on T 1-weighted MRI follow- ing surgery for a portosystemic shunt in an 8-year-old girl.
Topics: Ammonia; Bile Acids and Salts; Child; Female; Follow-Up Studies; Globus Pallidus; Hepatic Encephalop | 1999 |
Evaluation of ammonia measurements in dogs with two analysers for use in veterinary practice.
Topics: Ammonia; Animals; Autoanalysis; Dog Diseases; Dogs; Evaluation Studies as Topic; Hepatic Encephalopa | 1999 |
Helicobacter pylori infection, plasma ammonia levels, and psychometric testing in cirrhotic patients.
Topics: Adult; Aged; Ammonia; Female; Helicobacter Infections; Helicobacter pylori; Hepatic Encephalopathy; | 1999 |
Hyperammonia and cerebral herniation: is an abnormality of ammonia metabolism responsible?
Topics: Ammonia; Brain; Encephalocele; Hepatic Encephalopathy; Humans; Intracranial Hypertension; Liver; Liv | 1999 |
Partial pressure of ammonia versus ammonia in hepatic encephalopathy.
Topics: Adult; Aged; Alkalosis; Ammonia; Blood Glucose; Brain; Electrolytes; Evoked Potentials, Somatosensor | 2000 |
Long-term treatment of portosystemic encephalopathy with oral branched-chain amino acids--a case report.
Topics: Administration, Oral; Amino Acids; Amino Acids, Branched-Chain; Ammonia; Biomarkers; Chronic Disease | 1999 |
Transplantation of highly differentiated immortalized human hepatocytes to treat acute liver failure.
Topics: Ammonia; Animals; Antigens, Polyomavirus Transforming; Cell Differentiation; Cell Line; Cell Transpl | 2000 |
Sleep disorders and portal-systemic encephalopathy following transjugular intrahepatic portosystemic stent shunt in patients with liver cirrhosis. Relation to plasma tryptophan.
Topics: Adult; Aged; Aged, 80 and over; Ammonia; Female; Follow-Up Studies; Hepatic Encephalopathy; Humans; | 1999 |
Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure.
Topics: Ammonia; Animals; Brain; Brain Edema; Extracellular Space; Glutamic Acid; Hepatic Artery; Hepatic En | 2000 |
Gauged attenuation of congenital portosystemic shunts: results in 160 dogs and 15 cats.
Topics: Abdomen; Alanine Transaminase; Ammonia; Analgesics, Opioid; Animals; Bile Acids and Salts; Buprenorp | 2000 |
Hyperammonemia impairs NMDA receptor-dependent long-term potentiation in the CA1 of rat hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; Ammonia; Animals; Chronic Disease; Electric Stimulation; Excitatory Pos | 2000 |
[A case of portal-systemic encephalopathy associated with Sheehan's syndrome].
Topics: Aged; Ammonia; Consciousness Disorders; Constipation; Embolization, Therapeutic; Female; Hepatic Enc | 2000 |
Effects of ammonia on pentylenetetrazole-induced seizure threshold.
Topics: Ammonia; Animals; Aspartic Acid; Brain; Dose-Response Relationship, Drug; Drug Interactions; gamma-A | 1999 |
Effect of portacaval anastomosis on glutamine synthetase protein and gene expression in brain, liver and skeletal muscle.
Topics: Ammonia; Animals; Brain; Gene Expression Regulation, Enzymologic; Glutamate-Ammonia Ligase; Hepatic | 1999 |
Hyperammonemia and chronic hepatic encephalopathy: an in vivo PMRS study of the rat brain.
Topics: Ammonia; Animals; Brain; Chronic Disease; Energy Metabolism; Hepatic Encephalopathy; Magnetic Resona | 2000 |
Loss of noradrenaline transporter sites in frontal cortex of rats with acute (ischemic) liver failure.
Topics: Acute Disease; Ammonia; Animals; Brain Edema; Carrier Proteins; Fluoxetine; Frontal Lobe; Hepatic En | 2001 |
[Chronic liver diseases. Hepatic encephalopathy too frequently overlooked?].
Topics: Ammonia; Dipeptides; Hepatic Encephalopathy; Humans; Lactulose; Liver Cirrhosis; Neomycin | 2000 |
Extracorporeal liver perfusion using human and pig livers for acute liver failure.
Topics: Adolescent; Adult; Ammonia; Animals; Antibodies, Anti-Idiotypic; Biopsy; Child; Endothelium, Vascula | 2000 |
Effect of sodium benzoate on blood ammonia response to oral glutamine challenge in cirrhotic patients: a note of caution.
Topics: Administration, Oral; Ammonia; Glutamine; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Male; Mid | 2000 |
Ammonia and endogenous benzodiazepine-like compounds in the pathogenesis of hepatic encephalopathy.
Topics: Ammonia; Benzodiazepines; Chromatography, High Pressure Liquid; Colorimetry; Female; Hepatic Encepha | 2001 |
Amino acid challenge in patients with cirrhosis: a model for the assessment of treatments for hepatic encephalopathy.
Topics: Amino Acids; Ammonia; Dose-Response Relationship, Drug; Electroencephalography; Female; Hemoglobins; | 2001 |
Cerebral blood flow velocity increases during a single treatment with the molecular adsorbents recirculating system in patients with acute on chronic liver failure.
Topics: Acute Disease; Adsorption; Adult; Ammonia; Arteries; Blood Flow Velocity; Cerebrovascular Circulatio | 2001 |
Therapeutic effect of balloon-occluded retrograde transvenous obliteration on portal-systemic encephalopathy in patients with liver cirrhosis.
Topics: Aged; Ammonia; Aspartate Aminotransferases; Balloon Occlusion; Bilirubin; Embolization, Therapeutic; | 2001 |
The protective effect of HD-03 in CCl4-induced hepatic encephalopathy in rats.
Topics: Alanine Transaminase; Ammonia; Animals; Aspartate Aminotransferases; Astrocytes; Carbon Tetrachlorid | 2001 |
An anxiolytic agent, dihydrohonokiol-B, inhibits ammonia-induced increases in the intracellular Cl(-) of cultured rat hippocampal neurons via GABA(c) receptors.
Topics: Ammonia; Ammonium Chloride; Animals; Anti-Anxiety Agents; Biphenyl Compounds; Chlorides; Dose-Respon | 2001 |
Type II (adult onset) citrullinaemia: clinical pictures and the therapeutic effect of liver transplantation.
Topics: Adolescent; Adult; Ammonia; Brain; Brain Edema; Citrulline; Citrullinemia; Cognition Disorders; Coma | 2001 |
The development of low-grade cerebral edema in cirrhosis is supported by the evolution of (1)H-magnetic resonance abnormalities after liver transplantation.
Topics: Ammonia; Brain; Brain Edema; Female; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Liver Transpla | 2001 |
[Chronic hepatic encephalopathy: the role of high serum manganese levels and its relation with basal ganglia lesions in nuclear magnetic resonance of the brain. Clinical case].
Topics: Ammonia; Basal Ganglia; Biomarkers; Chronic Disease; Female; Hepatic Encephalopathy; Humans; Magneti | 2001 |
Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure.
Topics: Ammonia; Animals; Brain; Brain Edema; Energy Metabolism; Hepatic Encephalopathy; Hypothermia, Induce | 2001 |
Ammonia induces the mitochondrial permeability transition in primary cultures of rat astrocytes.
Topics: Ammonia; Ammonium Chloride; Animals; Animals, Newborn; Astrocytes; Benzimidazoles; Brain; Calcineuri | 2001 |
Taurine, glutamine, glutamate, and aspartate content and efflux, and cell volume of cerebrocortical minislices of rats with hepatic encephalopathy: influence of ammonia.
Topics: Ammonia; Animals; Aspartic Acid; Cell Size; Cerebral Cortex; Glutamic Acid; Glutamine; Hepatic Encep | 2000 |
Reduced encephalopathy in pigs with ischemia-induced acute hepatic failure treated with a bioartificial liver containing alginate-entrapped hepatocytes.
Topics: Alginates; Ammonia; Animals; Female; Hepatic Encephalopathy; Hepatocytes; Intracranial Pressure; Liv | 2002 |
[Ammoniuria and its relation to hydroionic factors and to the precoma situation in liver cirrhosis: the kidney as an excretory organ of ammonia].
Topics: Ammonia; Diuresis; Female; Hepatic Encephalopathy; Humans; Hydrogen-Ion Concentration; Kidney; Liver | 1975 |
[Acute hepatocellular insufficiency or severe jaundice].
Topics: Acute Disease; Ammonia; Brain Diseases, Metabolic; Chemical and Drug Induced Liver Injury; Citric Ac | 1976 |
[Pathogenesis of hepatic encephalopathy (author's transl)].
Topics: Alkalosis; Amino Acids; Ammonia; Anemia; Animals; Brain; Brain Edema; Carbon Dioxide; Catecholamines | 1977 |
[Metabolic disorders in experimental hepatic insufficiency and parenteral feeding].
Topics: 5-Hydroxytryptophan; Amino Acids; Ammonia; Animals; Blood Coagulation; Blood Transfusion; Choline; D | 1977 |
Lactulose: a drug in search of a modus operandi.
Topics: Ammonia; Colon; Disaccharides; Escherichia coli; Feces; Galactosides; Hepatic Encephalopathy; Humans | 1978 |
Reversible modifications of neurotransmitters of the brain in experimental acute hepatic coma.
Topics: Acrylic Resins; Acrylonitrile; Acute Disease; Amino Acids; Ammonia; Animals; Brain; Cellulose; Coppe | 1978 |
Ammonia intoxication: changes of brain levels of putative neutrotransmitters and related compounds and its relevance to hepatic coma.
Topics: Amino Acids; Ammonia; Animals; Body Temperature; Brain Chemistry; Enzymes; Hepatic Encephalopathy; H | 1978 |
Preventing portal systemic encephalopathy in the patient with cirrhosis.
Topics: Ammonia; Anemia; Dietary Carbohydrates; Dietary Proteins; Gastrointestinal Hemorrhage; Hepatic Encep | 1979 |
Hyperammonaemia, plasma aminoacid imbalance, and blood-brain aminoacid transport: a unified theory of portal-systemic encephalopathy.
Topics: Amino Acids, Branched-Chain; Ammonia; Animals; Biological Transport; Blood-Brain Barrier; Brain; Dog | 1979 |
Possible role of hyperammonaemia and/or of portosystemic shunts on the variability of the TSH response to TRH in cirrhotic patients.
Topics: Adult; Aged; Ammonia; Female; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Liver Function Tests; | 1978 |
Interposition mesocaval shunt for bleeding esophageal varices: clinical, hemodynamic, and metabolic changes.
Topics: Adult; Ammonia; Blood Vessel Prosthesis; Esophageal and Gastric Varices; Female; Follow-Up Studies; | 1978 |
Effect of total hepatectomy on selected cerebral substrates and enzymes of the glycolytic pathways and Krebs cycle.
Topics: Adenosine Triphosphatases; Ammonia; Animals; Brain; Citrates; Citric Acid Cycle; Dihydroxyacetone Ph | 1975 |
Exchange transfusion to remove ammonia.
Topics: Adult; Age Factors; Ammonia; Brain Diseases; Child; Evaluation Studies as Topic; Exchange Transfusio | 1975 |
On mechanisms in hyperammonemic coma--with particular reference to hepatic encephalopathy.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Ammonia; Aspartic Acid; Brain; Dose-Response Relation | 1975 |
The rectal administration of lactulose.
Topics: Aged; Ammonia; Colon; Disaccharides; Electroencephalography; Enema; Hepatic Encephalopathy; Humans; | 1975 |
Studies on plasma cytotoxicity and liver regeneration in fulminant hepatic failure.
Topics: Ammonia; Animals; Chenodeoxycholic Acid; Cytotoxins; Dialysis; Hemoperfusion; Hepatic Encephalopathy | 1977 |
CBF and metabolism in hepatic encephalopathy: effects of acute hyperammoneamia and of L. dopa.
Topics: Ammonia; Brain; Cerebrovascular Circulation; Glucose; Hepatic Encephalopathy; Humans; Levodopa | 1977 |
Brain energy metabolism and alterations of transmitter profiles in acute hepatic coma.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Ammonia; Animals; Brain; Ene | 1978 |
[Changes in arterial blood ammonia levels in cirrhosis. Study during and after mannitol lavage in post-hemorrhagic hepatic encephalopathy].
Topics: Adult; Aged; Ammonia; Female; Gastric Lavage; Gastrointestinal Hemorrhage; Hepatic Encephalopathy; H | 1978 |
Quantitative tests of nitrogen metabolism in cirrhosis: relation to other manifestations of liver disease.
Topics: Adult; Amino Acids; Ammonia; Ammonium Chloride; Aspartate Aminotransferases; Bilirubin; Cholesterol; | 1978 |
Octopamine and ammonia plasma levels in hepatic encephalopathy.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Octopamine | 1977 |
Serum polyamine and octopamine changes following partial hepatectomy and portacaval shunt.
Topics: Ammonia; Child, Preschool; Hepatectomy; Hepatic Duct, Common; Hepatic Encephalopathy; Humans; Liver; | 1977 |
[New aspects of the pathogenesis and therapy of alcoholic delirium (author's transl)].
Topics: Alcohol Withdrawal Delirium; Alcoholism; Ammonia; Chlormethiazole; Fatty Liver; Hepatic Encephalopat | 1977 |
[Hyperammonemia during parenteral nutrition of intensive-care patients].
Topics: Adult; Amino Acids; Ammonia; Blood Urea Nitrogen; Critical Care; Female; Hepatic Encephalopathy; Hum | 1977 |
Hyperammonemic coma after hepatectomy in germ-free rats.
Topics: Ammonia; Animals; Bacteria; Bacterial Toxins; Disease Models, Animal; Germ-Free Life; Hepatectomy; H | 1979 |
Portal vein ammonia infusions.
Topics: Ammonia; Ammonium Chloride; Ammonium Sulfate; Animals; Dogs; Hepatic Encephalopathy; Infusions, Pare | 1979 |
What determines blood ammonia?
Topics: Ammonia; Animals; Bacteria; Dietary Proteins; Hepatic Encephalopathy; Humans; Intestine, Small; Kidn | 1979 |
Hyperammonemia associated with perinatal asphyxia.
Topics: Ammonia; Asphyxia Neonatorum; Female; Fever; Follow-Up Studies; Heart Rate; Hepatic Encephalopathy; | 1979 |
[Determination of ammonia].
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Methods | 1979 |
Blood ammonia level.
Topics: Ammonia; Animals; Hepatic Encephalopathy; Humans; Intestinal Mucosa; Renal Dialysis; Swine | 1979 |
Emergency treatment of portal-systemic encephalopathy with lactulose enemas. A controlled study.
Topics: Ammonia; Disaccharides; Emergencies; Enema; Female; Hepatic Encephalopathy; Humans; Lactulose; Liver | 1979 |
Comparative value of different dialysis membranes, including a carbon coated membrane for removal of noxious substances in hepatic coma.
Topics: Absorption; Ammonia; Dialysis; Fatty Acids, Volatile; Glycocholic Acid; Hepatic Encephalopathy; Huma | 1979 |
[Clinico-diagnostic and prognostic value of various indicators of nitrogen metabolism in hepatic coma].
Topics: Adolescent; Adult; Aged; Ammonia; Female; Glutamine; Hepatic Encephalopathy; Humans; Middle Aged; Pr | 1979 |
High-permeability membrane hemodialysis and hemofiltration in acute hepatic coma: experimental and clinical results.
Topics: Amino Acids; Ammonia; Animals; Blood; Brain; Cellulose; Hepatic Encephalopathy; Humans; Membranes, A | 1979 |
Chronic liver failure.
Topics: Ammonia; Anti-Bacterial Agents; Ascites; Chronic Disease; Diagnosis, Differential; Diuretics; Edema; | 1979 |
Surgical treatment for portosystemic shunts in two dogs.
Topics: Ammonia; Animals; Dog Diseases; Dogs; Female; Hepatic Encephalopathy; Male; Mesenteric Veins; Portal | 1977 |
A light and electron microscopic study of experimental portal-systemic (ammonia) encephalopathy. Progression and reversal of the disorder.
Topics: Alzheimer Disease; Ammonia; Animals; Astrocytes; Cerebral Cortex; Cytoplasm; Endoplasmic Reticulum; | 1977 |
Chronic inhibition of brain protein synthesis after portacaval shunting. A possible pathogenic mechanism in chronic hepatic encephalopathy in the rat.
Topics: Ammonia; Animals; Brain; Electroencephalography; Hepatic Encephalopathy; Lysine; Muscles; Nerve Tiss | 1978 |
[Glutamic acid gamma-ethyl ester in high doses in the treatment of high blood ammonia levels in severe hepatic failure].
Topics: Acid-Base Imbalance; Ammonia; Glutamates; Hepatic Encephalopathy; Humans; Injections, Intravenous; L | 1978 |
Cross circulation for hepatic coma.
Topics: Acidosis; Ammonia; Cross Circulation; Exchange Transfusion, Whole Blood; Hepatic Encephalopathy; Hum | 1977 |
[Hyperammonemia and hepatic encephalopathy in cirrhotics receiving spironolactone (author's transl)].
Topics: Adult; Aged; Ammonia; Hepatic Encephalopathy; Humans; Intestinal Mucosa; Liver Cirrhosis; Male; Midd | 1977 |
Ornicetil on encephalopathy. Effect of ornicetil (ornithine alpha-ketoglutarate) on encephalopathy in patients with acute and chronic liver disease.
Topics: Acute Disease; Adult; Ammonia; Chronic Disease; Drug Evaluation; Female; Hepatic Encephalopathy; Hum | 1977 |
A model of fulminant hepatic failure in the rabbit.
Topics: Alkaline Phosphatase; Amino Acids; Ammonia; Animals; Aspartate Aminotransferases; Blood Coagulation | 1978 |
Hepatic encephalopathy in a dog.
Topics: Ammonia; Animals; Dog Diseases; Dogs; Hepatic Encephalopathy; Liver Function Tests | 1978 |
Exacerbation of hepatic encephalopathy by chronic renal failure: response to maintenance hemodialysis.
Topics: Adult; Ammonia; Hepatic Encephalopathy; Humans; Kidney; Kidney Failure, Chronic; Liver Cirrhosis, Al | 1978 |
Subclinical hepatic encephalopathy: detection, prevalence, and relationship to nitrogen metabolism.
Topics: Ammonia; Antipyrine; Electroencephalography; Fatty Liver, Alcoholic; Female; Galactose; Hepatic Ence | 1978 |
[Changes of plasmatic amino acids in various cases of acute hepatic necrosis and insufficiency in man].
Topics: Adolescent; Adult; Amino Acids; Ammonia; Child; Female; Hepatic Encephalopathy; Humans; Insulin; Liv | 1978 |
Biochemical correlates of reversal of hepatic coma coated with charcoal hemoperfusion.
Topics: Adolescent; Adult; Amino Acids; Ammonia; Catecholamines; Charcoal; Female; Hemoperfusion; Hepatic En | 1978 |
[Contribution to the treatment of portal systemic encephalopathy (author's transl)].
Topics: Aged; Ammonia; Electroencephalography; Female; Hepatic Encephalopathy; Humans; Hypertension, Portal; | 1978 |
[Preliminary observations on a possible increase in blood ammonia in hemodynamic changes of the cerebral circulation].
Topics: Aged; Ammonia; Cerebrovascular Circulation; Cerebrovascular Disorders; Female; Hemodynamics; Hepatic | 1978 |
Hypertyraminemia in cirrhotic patients.
Topics: Adult; Aged; Ammonia; Blood Pressure; Brain; Dietary Proteins; Hepatic Encephalopathy; Humans; Liver | 1976 |
The role of plasma amino acids in hepatic encephalopathy.
Topics: Albumins; Amino Acids; Ammonia; Animals; Arginine; Blood Urea Nitrogen; Dogs; Glucose; Glutamates; H | 1975 |
The effect of normalization of plasma amino acids on hepatic encephalopathy in man.
Topics: Adult; Aged; Albumins; Amino Acids; Ammonia; Body Weight; Electroencephalography; Female; Glucose; H | 1976 |
The effect of normalization of plasma amino acids on hepatic encephalopathy in man.
Topics: Adult; Aged; Albumins; Amino Acids; Ammonia; Body Weight; Electroencephalography; Female; Glucose; H | 1976 |
The effect of normalization of plasma amino acids on hepatic encephalopathy in man.
Topics: Adult; Aged; Albumins; Amino Acids; Ammonia; Body Weight; Electroencephalography; Female; Glucose; H | 1976 |
The effect of normalization of plasma amino acids on hepatic encephalopathy in man.
Topics: Adult; Aged; Albumins; Amino Acids; Ammonia; Body Weight; Electroencephalography; Female; Glucose; H | 1976 |
[Present-day therapy of hepatic encephalopathy (author's transl)].
Topics: Acid-Base Imbalance; Ammonia; Anemia; Anti-Bacterial Agents; Exchange Transfusion, Whole Blood; Gluc | 1976 |
[Current therapeutic possibilities in hepatic encephalopathy].
Topics: Acid-Base Imbalance; Ammonia; Bicarbonates; Glucose; Glutamates; Hepatic Encephalopathy; Humans | 1977 |
Glial cell reactions in rats with hyperammoniemia induced by urease or porto-caval anastomosis.
Topics: Ammonia; Animals; Astrocytes; Cell Nucleus; Corpus Striatum; Hepatic Encephalopathy; Male; Mitosis; | 1977 |
[Hepatic insufficiency - clinical picture].
Topics: Acidosis; Ammonia; Blood Coagulation Disorders; Carbohydrate Metabolism; Estrogens; Hepatic Encephal | 1977 |
[Blood perfusion of the liver under physiological and pathological conditions - mechanisms and clinical importance (author's transl)].
Topics: Ammonia; Hepatic Artery; Hepatic Encephalopathy; Humans; Liver Circulation; Liver Cirrhosis; Microci | 1977 |
[Clinical picture and therapy of portal-systemic encephalopathy (author's transl)].
Topics: Acetates; Acidosis; Alcoholism; Amino Acids; Ammonia; Astrocytes; Dietary Proteins; Diuretics; Hemor | 1977 |
The effect of acute and subacute ammonia intoxication on regional cerebral acetylcholine levels in rats.
Topics: Acetylcholine; Ammonia; Animals; Body Temperature; Brain; Female; Hepatic Encephalopathy; Rats; Seiz | 1977 |
Hemodialysis against activated charcoal suspension as a treatment of hepatic encephalopathy.
Topics: Amino Acids; Ammonia; Animals; Blood Urea Nitrogen; Charcoal; Dogs; Hemoperfusion; Hepatectomy; Hepa | 1977 |
[Therapy of hepatic insufficiency].
Topics: Alcoholism; Ammonia; Dietary Proteins; Exchange Transfusion, Whole Blood; Hepatic Encephalopathy; Hu | 1977 |
[Hepatic encephalopathies; hemodynamic and metabolic study of the influence of ammonia and levodopa].
Topics: Ammonia; Blood Glucose; Carbon Dioxide; Cerebrovascular Circulation; Energy Metabolism; Hepatic Ence | 1977 |
Effects of keto analogues of essential amino acids in portal-systemic encephalopathy.
Topics: Administration, Oral; Amino Acids; Amino Acids, Essential; Ammonia; Blood Urea Nitrogen; Electroence | 1976 |
Histochemical studies in experimental portal-systemic encephalopathy.
Topics: Alzheimer Disease; Ammonia; Animals; Cerebral Cortex; Disease Models, Animal; Glutamate Dehydrogenas | 1976 |
Lactulose (cephulac) in portosystemic encephalopathy.
Topics: Ammonia; Depression, Chemical; Disaccharides; Hepatic Encephalopathy; Humans; Lactulose; Recurrence | 1976 |
Effect of ammonia on cerebral metabolism of rats with portocaval shunts.
Topics: Ammonia; Animals; Brain; Disease Models, Animal; Hepatic Encephalopathy; Male; Portacaval Shunt, Sur | 1976 |
[Acute hepatic coma in complete liver ischemia].
Topics: Ammonia; Animals; Blood Coagulation Disorders; Blood Coagulation Factors; Disseminated Intravascular | 1976 |
[Studies on the importance of endogenous toxins for the origin of hepatic coma].
Topics: Ammonia; Fatty Acids, Nonesterified; Hepatic Encephalopathy; Phenols; Sulfhydryl Compounds; Toxins, | 1976 |
[Hepatic coma (author's transl)].
Topics: Adolescent; Adult; Aged; Ammonia; Female; Hepatic Encephalopathy; Humans; Male; Middle Aged | 1976 |
Chronic hepatic encephalopathy.
Topics: Amino Acids, Essential; Ammonia; Analgesics; Anesthesia; Anti-Bacterial Agents; Biogenic Amines; Chr | 1975 |
Approaches to the management of fulminant hepatic failure.
Topics: Acidosis; Adrenal Cortex Hormones; Ammonia; Animals; Exchange Transfusion, Whole Blood; Extracorpore | 1975 |
The normal colonic bacterial flora.
Topics: Ammonia; Bacteria; Bacteroides; Bile Acids and Salts; Carcinogens; Chloramphenicol; Clostridium; Col | 1975 |
Letter: Ammonia and L-dopa: Parkinson's disease and hepatic encephalopathy.
Topics: Ammonia; Animals; Dietary Proteins; Hepatic Encephalopathy; Humans; Levodopa; Parkinson Disease | 1975 |
Exchange transfusion in hepatic coma: factors affecting results, with long-term follow-up data.
Topics: Adolescent; Adult; Aged; Ammonia; Bilirubin; Biopsy; Chemical and Drug Induced Liver Injury; Child; | 1975 |
[Hyperammoniemia and porta-caval encephalopathy in patients with cirrhosis. Personal results of lactulose treatment].
Topics: Adult; Aged; Ammonia; Disaccharides; Female; Hepatic Encephalopathy; Humans; Lactulose; Liver Cirrho | 1975 |
Methionine-induced hepatic coma in dogs.
Topics: Administration, Oral; Ammonia; Animals; Brain; Disease Models, Animal; Dogs; Hepatic Encephalopathy; | 1975 |
[Acute liver insufficiency: precoma - coma].
Topics: Ammonia; Hepatic Encephalopathy; Hepatitis; Humans; Serotonin | 1975 |
Intestinal bacteria and protein metabolism in human liver cirrhosis.
Topics: Ammonia; Bacteria; Hepatic Encephalopathy; Humans; Intestines; Liver Cirrhosis; Male; Middle Aged; P | 1975 |
Hyperammonemia and hepatic encephalopathy in the dog.
Topics: Alanine Transaminase; Alkaline Phosphatase; Ammonia; Anemia; Animals; Bilirubin; Blood Glucose; Bloo | 1975 |
Hepatic coma: theory and therapy. Part I. Biochemical mechanisms.
Topics: Adolescent; Adult; Aged; Ammonia; Child; Female; Hepatic Encephalopathy; Humans; Male; Middle Aged | 1975 |
[Encephalopathy in acute hepatic atrophy. Effect of the purification of middle molecules. Preliminary results].
Topics: Adult; Aged; Amino Acids; Ammonia; Fatty Acids, Nonesterified; Female; Hepatic Encephalopathy; Hepat | 1975 |
[Therapy of coma in liver cirrhosis].
Topics: Adenosine Triphosphate; Ammonia; Arginine; Brain; Colon; Disaccharides; Hepatic Encephalopathy; Huma | 1975 |
Cerebrospinal fluid glutamine in Reye's syndrome.
Topics: Ammonia; Brain Diseases; Child; Child, Preschool; Glutamine; Hepatic Encephalopathy; Humans; Infant; | 1975 |
Letter: Hyperammonemia and hepatic encephalopathy in the dog.
Topics: Ammonia; Animals; Dog Diseases; Dogs; Hepatic Encephalopathy | 1976 |
Muscle nitrogen metabolism in chronic hepatic insufficiency.
Topics: Adult; Aged; Alanine; Alcoholism; Amino Acids; Ammonia; Brachial Artery; Female; Forearm; Glutamine; | 1976 |
[Extracorporeal fixation of liver slices onto the system of "artificial kidney" apparatus].
Topics: Adult; Ammonia; Animals; Bilirubin; Dogs; Hepatic Encephalopathy; Humans; Kidneys, Artificial; Liver | 1976 |
Characteristics of large neutral amino acid-induced release of preloaded L-glutamine from rat cerebral capillaries in vitro: effects of ammonia, hepatic encephalopathy, and gamma-glutamyl transpeptidase inhibitors.
Topics: Amino Acids; Ammonia; Animals; Blood-Brain Barrier; Brain; Capillaries; Chromatography, High Pressur | 1992 |
Effect of three antibacterial drugs in lowering blood & stool ammonia production in hepatic encephalopathy.
Topics: Administration, Oral; Ammonia; Ampicillin; Feces; Hepatic Encephalopathy; Humans; Hydrogen-Ion Conce | 1992 |
Cerebral cortex ammonia and glutamine metabolism during liver insufficiency-induced hyperammonemia in the rat.
Topics: Ammonia; Animals; Arteries; Cerebral Cortex; Glutamine; Hepatic Encephalopathy; Ischemia; Liver Circ | 1992 |
Changes in brain ECF amino acids in rats with experimentally induced hyperammonemia.
Topics: Amino Acids; Ammonia; Animals; Brain; Extracellular Space; Hepatic Encephalopathy; Male; Rats; Rats, | 1992 |
The use of in vivo proton NMR to study the effects of hyperammonemia in the rat cerebral cortex.
Topics: Ammonia; Animals; Cerebral Cortex; Choline; Glutamates; Glutamic Acid; Glutamine; Hepatic Encephalop | 1991 |
Regulatory effect of neurotransmitter by hemofiltration in cardiogenic shock patients after open heart surgery.
Topics: Adolescent; Adult; Aged; Ammonia; Aspartic Acid; Brain Edema; Coronary Artery Bypass; Female; Glasgo | 1991 |
Effects of acute hepatic encephalopathy and in vitro treatment with ammonia on glutamate oxidation in bulk-isolated astrocytes and mitochondria of the rat brain.
Topics: Ammonia; Animals; Astrocytes; Brain; Female; Glutamates; Glutamic Acid; Hepatic Encephalopathy; In V | 1991 |
[Positron emission tomography (PET) before and after treatment of hyperammonemia in a patient with decompensated liver cirrhosis].
Topics: Ammonia; Cerebrovascular Circulation; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Male; Middle | 1991 |
Reduced cholecystokinin in the brain of LEC rats with hepatic encephalopathy.
Topics: Amino Acids; Ammonia; Animals; Brain; Cerebral Cortex; Cholecystokinin; Hepatic Encephalopathy; Immu | 1991 |
[Countermeasures for hepatic encephalopathy complicated with liver cirrhosis].
Topics: Administration, Oral; Amino Acids; Ammonia; Anti-Bacterial Agents; Hepatic Encephalopathy; Humans; L | 1991 |
Aspartate aminotransferase, malate dehydrogenase, and pyruvate carboxylase activities in rat cerebral synaptic and nonsynaptic mitochondria: effects of in vitro treatment with ammonia, hyperammonemia and hepatic encephalopathy.
Topics: Ammonia; Animals; Aspartate Aminotransferases; Hepatic Encephalopathy; In Vitro Techniques; Malate D | 1991 |
Hepatic failure and coma after liver resection is reversed by manipulation of gut contents: the role of endotoxin.
Topics: Ammonia; Analysis of Variance; Animals; Cefazolin; Cholestyramine Resin; Endotoxins; Gastrointestina | 1991 |
A new surgical model of acute liver failure in the pig: experimental procedure and analysis of liver injury.
Topics: Ammonia; Animals; Aspartate Aminotransferases; Bilirubin; Disease Models, Animal; Female; Hepatectom | 1991 |
Taurine release from brain slices in thioacetamide-induced hepatic encephalopathy in rats.
Topics: Ammonia; Ammonium Chloride; Animals; Brain Chemistry; Corpus Striatum; Hepatic Encephalopathy; Male; | 1991 |
Metabolic encephalopathy: mechanisms affecting limbic function.
Topics: Action Potentials; Ammonia; Animals; Blood-Brain Barrier; Cachexia; Energy Metabolism; Feeding and E | 1990 |
Hepatic encephalopathy influences high-affinity uptake of transmitter glutamate and aspartate into the hippocampal formation.
Topics: Adult; Aged; Aged, 80 and over; Ammonia; Animals; Aspartic Acid; Female; Glutamates; Glutamic Acid; | 1990 |
International symposium on cirrhosis, hepatic encephalopathy and ammonium toxicity. Valencia, Spain, November 27-29, 1989. Proceedings.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis | 1990 |
Cerebral ammonia metabolism in patients with severe liver disease and minimal hepatic encephalopathy.
Topics: Adult; Ammonia; Blood-Brain Barrier; Brain; Cerebrovascular Circulation; Female; Hepatic Encephalopa | 1991 |
The role of methanethiol in the pathogenesis of hepatic encephalopathy.
Topics: Adult; Ammonia; Disulfides; Female; Hepatic Encephalopathy; Humans; Liver Diseases; Male; Methionine | 1991 |
Congenital portosystemic shunts (PSS) in dogs are a genetic disorder.
Topics: Ammonia; Animals; Disease Models, Animal; Dog Diseases; Dogs; Female; Hepatic Encephalopathy; Male; | 1991 |
The relationship between plasma free fatty acids and experimentally induced hepatic encephalopathy in the rat.
Topics: Acute Disease; Ammonia; Animals; Chronic Disease; Fatty Acids, Nonesterified; Hepatic Encephalopathy | 1991 |
[Probable correlations ultrastructural anomalies of the central nervous system and hyperammonemia following portacaval anastomosis in rats].
Topics: Ammonia; Animals; Brain; Central Nervous System; Hepatic Encephalopathy; Male; Microscopy, Electron; | 1991 |
[Possibilities of hemosorption using a fibrous sorbent in acute hepatic failure (experimental study)].
Topics: Acrylic Resins; Acute Disease; Ammonia; Animals; Bilirubin; Blood Proteins; Disease Models, Animal; | 1990 |
[Autoradiography determination of the GABA(A) receptor density in the brain of rats with portacaval shunt].
Topics: Ammonia; Animals; Autoradiography; Brain; Cerebellar Cortex; Cerebral Cortex; Hepatic Encephalopathy | 1990 |
Reversal of chronic hepatic encephalopathy by colonic exclusion: poor correlation with blood GABA levels.
Topics: Ammonia; Chronic Disease; Electroencephalography; Female; gamma-Aminobutyric Acid; Hepatic Encephalo | 1990 |
[Effect of differentiated diet therapy on the clinical results and biochemical indicators in chronic hepatic encephalopathy].
Topics: Amino Acids; Amino Acids, Branched-Chain; Ammonia; Brain; Brain Chemistry; Chronic Disease; Dietary | 1990 |
Hepatic encephalopathy induced by small bowel obstruction in a noncirrhotic child with portal vein thrombosis.
Topics: Adolescent; Ammonia; Graft Occlusion, Vascular; Hepatic Encephalopathy; Humans; Intestinal Obstructi | 1990 |
Septic encephalopathy. Evidence for altered phenylalanine metabolism and comparison with hepatic encephalopathy.
Topics: Ammonia; Bacterial Infections; Brain Diseases, Metabolic; Glutamine; Hepatic Encephalopathy; Humans; | 1990 |
Fulminant hepatic failure in poisoning due to ingestion of T 61, a veterinary euthanasia drug.
Topics: Amides; Ammonia; Dimethylformamide; Drug Combinations; Drug Overdose; Female; Hepatic Encephalopathy | 1990 |
Methanethiol metabolism and its role in the pathogenesis of hepatic encephalopathy in rats and dogs.
Topics: Administration, Inhalation; Ammonia; Animals; Colon; Disulfides; Dogs; Hepatic Encephalopathy; Injec | 1990 |
[Hepatic encephalopathy].
Topics: Amino Acids; Ammonia; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Neurotoxins; Neurotra | 1986 |
Effect of ammonia on cyclic AMP production in primary astrocyte cultures.
Topics: 1-Methyl-3-isobutylxanthine; Ammonia; Animals; Astrocytes; Cells, Cultured; Cyclic AMP; Hepatic Ence | 1986 |
The effect of blood ingestion on brain serotonin synthesis in portacaval-shunted rats.
Topics: 5-Hydroxytryptophan; Amino Acids; Ammonia; Animals; Blood; Brain; Disease Models, Animal; Explorator | 1987 |
[Studies of the effect of a protein-free diet and branched-chain amino acids (preparation Aminosteril-Hepa) on selected biochemical indicators in chronic experimental hepatic encephalopathy].
Topics: Amino Acids; Amino Acids, Branched-Chain; Ammonia; Animals; Chronic Disease; Dietary Proteins; Hepat | 1989 |
Functional changes of brain mitochondria during experimental hepatic encephalopathy.
Topics: Adenosine Triphosphatases; Ammonia; Animals; Brain Chemistry; Carbon Tetrachloride; Cytochromes; Fat | 1989 |
[Propranolol and the risk of hepatic encephalopathy in liver cirrhosis].
Topics: Ammonia; Cerebrovascular Circulation; Electroencephalography; Esophageal and Gastric Varices; Heart | 1989 |
[Significance of serum ammonia nitrogen analysis in clinical tests].
Topics: Ammonia; Colorimetry; Hepatic Encephalopathy; Humans; Microchemistry; Reference Values; Spectrophoto | 1989 |
Correlations between zinc, amino acids and ammonia in liver cirrhosis.
Topics: Amino Acids; Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Liver Function Tests; Zinc | 1989 |
Effect of oral adsorbent on blood metabolites in hepatic failure dogs.
Topics: Administration, Oral; Adsorption; Ammonia; Animals; Bile Acids and Salts; Carbon; Chromatography, Hi | 1989 |
Ammonia encephalopathy.
Topics: Aged; Ammonia; Colon, Sigmoid; Female; Hepatic Encephalopathy; Humans; Postoperative Complications; | 1989 |
[A case of chronic recurrent portal systemic encephalopathy showing marked diurnal fluctuation of blood ammonia level complicated with central pontine myelinolysis].
Topics: Adult; Ammonia; Chronic Disease; Circadian Rhythm; Demyelinating Diseases; Hepatic Encephalopathy; H | 1989 |
Effect of ammonia on plasma and cerebrospinal fluid amino acids in dogs with and without portacaval anastomoses.
Topics: Amino Acids; Ammonia; Animals; Blood-Brain Barrier; Dogs; Female; Glutamates; Glutamic Acid; Glutami | 1985 |
Hepatic encephalopathy and the neural regulation of hypothalamic pituitary function.
Topics: Amino Acids; Ammonia; Animals; Blood-Brain Barrier; Brain; Catecholamines; Fatty Acids; gamma-Aminob | 1985 |
Hepatic encephalopathy.
Topics: Ammonia; Animals; Brain; Cat Diseases; Cats; Chronic Disease; Dog Diseases; Dogs; Hepatic Encephalop | 1985 |
[Metabolic principles in hepatic encephalopathy].
Topics: Amino Acids; Ammonia; Blood-Brain Barrier; Brain; Evoked Potentials, Visual; Fatty Acids; gamma-Amin | 1985 |
[Prevention and therapy of portosystemic encephalopathy].
Topics: Amino Acids; Ammonia; Animals; Hepatic Encephalopathy; Humans; Hypertension, Portal; Liver; Liver Ci | 1985 |
Portal-systemic encephalopathy and hepatic coma.
Topics: Amino Acids; Ammonia; Dietary Proteins; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Lac | 1986 |
Reduced somatostatin-like immunoreactivity in the brain of dogs with an Eck fistula.
Topics: Amino Acids; Ammonia; Animals; Chromatography, Gel; Disease Models, Animal; Dogs; Hepatic Encephalop | 1987 |
Changes in glutamate-cycle enzyme mRNA levels in a rat model of hepatic encephalopathy.
Topics: Amino Acids; Ammonia; Animals; Brain; Energy Metabolism; Glutamate Decarboxylase; Glutamate Dehydrog | 1988 |
Amino acid neurotransmitters and their receptors in the brain synaptosomes of acute hepatic failure rats.
Topics: Acute Disease; Amino Acids; Ammonia; Animals; Brain; Glutamates; Hepatic Encephalopathy; Male; Neuro | 1988 |
Continuous intravenous ammonia infusion as a model for the study of hepatic encephalopathy in rabbits.
Topics: Acetates; Acetic Acid; Ammonia; Animals; Blood Glucose; Disease Models, Animal; Electroencephalograp | 1989 |
Episodic confusion and tremor associated with extrahepatic portacaval shunting in cirrhotic liver disease.
Topics: Aged; Ammonia; Cognition Disorders; Confusion; Hepatic Encephalopathy; Humans; Liver Cirrhosis, Alco | 1989 |
Blood ammonia levels and hepatic encephalopathy induced by CCl4 in rats.
Topics: Adenosine Triphosphate; Ammonia; Animals; Argininosuccinate Synthase; Ca(2+) Mg(2+)-ATPase; Carbamoy | 1987 |
Changes in arterial and cerebral venous blood gases, cerebral blood flow and cerebral oxygen consumption at different stages of thioacetamide-induced hepatogenic encephalopathy in rat.
Topics: Ammonia; Animals; Brain; Brain Chemistry; Carbon Dioxide; Cerebrovascular Circulation; Female; Hepat | 1986 |
Hepatic encephalopathy. Application of visual evoked responses to test hypotheses of its pathogenesis in rats.
Topics: Ammonia; Animals; Caprylates; Disulfides; Evoked Potentials, Visual; gamma-Aminobutyric Acid; Hepati | 1987 |
[Significance of fecal Bacteroides in hepatic encephalopathy with hyperammonemia].
Topics: Ammonia; Bacteroides; Feces; Female; Hepatic Encephalopathy; Humans; Male; Middle Aged; Vancomycin | 1986 |
[Study of the ameliorating effects of an enteral nutrient for liver failure on hepatic encephalopathy: effects of SF-1008C on plasma and brain free amino acids, intracerebral amine concentrations and electroencephalogram in portacaval shunted rats with am
Topics: Amino Acids; Amino Acids, Branched-Chain; Ammonia; Animals; Biogenic Amines; Brain Chemistry; Electr | 1986 |
[Protein and amino acid metabolism in liver failure--therapeutic infusion and dietary sequelae].
Topics: Amino Acids; Ammonia; Hepatic Encephalopathy; Humans; Liver; Parenteral Nutrition, Total; Proteins | 1986 |
Acute ammonia intoxication 37 years after ureterosigmoidostomy.
Topics: Acute Disease; Adult; Ammonia; Colon, Sigmoid; Hepatic Encephalopathy; Humans; Magnetic Resonance Im | 1988 |
Canine congenital portosystemic encephalopathy.
Topics: Ammonia; Animals; Dog Diseases; Dogs; Female; Hepatic Encephalopathy; Male; Portal Vein; Portography | 1988 |
Clinical studies on zinc in chronic liver diseases.
Topics: Adult; Ammonia; Chemical and Drug Induced Liver Injury; Fatty Liver, Alcoholic; Female; Hepatic Ence | 1988 |
[Hepatic encephalopathy: a clinical analysis of 107 cases].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acids, Branched-Chain; Ammonia; Female; Hepatic En | 1988 |
In vivo 31P NMR spectroscopy of the rat cerebral cortex during acute hepatic encephalopathy.
Topics: Adenosine Triphosphate; Amino Acids; Ammonia; Animals; Cerebral Cortex; Electroencephalography; Hepa | 1988 |
[The clinical course of hepato-cerebral degeneration due to portal-systemic shunt, as examined by constructional ability of plane and cube].
Topics: Ammonia; Apraxias; Brain; Hepatic Encephalopathy; Humans; Male; Middle Aged; Neuropsychological Test | 1988 |
Hepatic ATP content and hyperammonemia induced by CCl4 in rats.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Ammonia; Animals; Argininosuccinate Synthase; Carbamoyl-P | 1988 |
Intestinal microflora changes induced by ciprofloxacin and treatment of portal-systemic encephalopathy (PSE).
Topics: Aged; Ammonia; Bacteria, Aerobic; Bacteria, Anaerobic; Ciprofloxacin; Endotoxins; Feces; Female; Hep | 1987 |
Morphometric and densitometric investigations of protoplasmic astrocytes and neurons in human hepatic encephalopathy.
Topics: Adolescent; Adult; Aged; Ammonia; Astrocytes; Cell Nucleus; Child; Child, Preschool; Female; Hepatic | 1987 |
Elevation of ammonia contents in the cerebral hemisphere under the blood-brain barrier opening.
Topics: Ammonia; Animals; Blood-Brain Barrier; Capillary Permeability; Deoxycholic Acid; Hepatic Encephalopa | 1987 |
[Clinical evaluation of branched chain amino acids for treatment of hepatic encephalopathy].
Topics: Adult; Aged; Amino Acids, Branched-Chain; Ammonia; Consciousness; Female; Hepatic Encephalopathy; Hu | 1986 |
Cerebral aminoacids in portal-systemic encephalopathy: lack of evidence for altered gamma-aminobutyric acid (GABA) function.
Topics: Amino Acids; Ammonia; Animals; Brain Stem; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamate Decar | 1986 |
Abstracts of the 6th International Symposium on Ammonia--Advances in Hepatic Encephalopathy and Urea Cycle Diseases. The Netherlands, 27-29 April, 1987.
Topics: Ammonia; Animals; Hepatic Encephalopathy; Humans; Urea | 1987 |
Correlation between electroencephalographic and biochemical indices in acute hepatic encephalopathy in rats.
Topics: Acute Disease; Alanine Transaminase; Amino Acids; Ammonia; Animals; Disease Models, Animal; Electroe | 1987 |
In hepatic coma, the problem comes from the colon, but will the answers come from there?
Topics: Ammonia; Bacteria; Colon; Disaccharides; Hepatic Encephalopathy; Humans; Lactulose; Neomycin; Nitrog | 1987 |
[Hepatic encephalopathy, an unwelcome patient].
Topics: Amino Acids; Ammonia; Hepatic Encephalopathy; Humans | 1987 |
A surgical model of fulminant hepatic failure in the rabbit: different effects of end-to-side versus small-diameter side-to-side portacaval shunt.
Topics: Ammonia; Animals; Blood Coagulation Factors; Disease Models, Animal; Electroencephalography; Female; | 1987 |
Metabolic encephalopathies: opportunities and challenges.
Topics: Ammonia; Animals; Brain; Brain Diseases; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Me | 1987 |
[Treatment of hepatic encephalopathy with oral branched-chain amino acids: I. Acute hepatic encephalopathy].
Topics: Acute Disease; Administration, Oral; Amino Acids, Branched-Chain; Ammonia; Female; Follow-Up Studies | 1987 |
[Treatment of hepatic encephalopathy with branched-chain amino acids (BCAA) by oral route: II. Chronic hepatic encephalopathy].
Topics: Administration, Oral; Aged; Amino Acids, Branched-Chain; Ammonia; Chronic Disease; Electroencephalog | 1987 |
Reduction of cerebral blood flow in subclinical hepatic encephalopathy and its correlation with plasma-free tryptophan.
Topics: Adult; Aged; Ammonia; Blood Flow Velocity; Cerebrovascular Circulation; Electroencephalography; Fema | 1987 |
Rendu-Osler-Weber disease with portosystemic encephalopathy.
Topics: Ammonia; Consciousness Disorders; Hepatic Encephalopathy; Humans; Liver; Male; Middle Aged; Portal S | 1987 |
The role of protein metabolism in 204 liver cirrhotics with and without hepatic encephalopathy. I. Clinical and general biochemical findings.
Topics: Adolescent; Adult; Ammonia; Blood Proteins; Female; Hepatic Encephalopathy; Hepatitis, Viral, Human; | 1986 |
Cerebral glucose metabolism after portacaval shunting in the rat. Patterns of metabolism and implications for the pathogenesis of hepatic encephalopathy.
Topics: Acetates; Ammonia; Animals; Brain; Electroencephalography; Glucose; Hepatic Encephalopathy; Male; Po | 1986 |
[Therapy of portosystemic encephalopathy].
Topics: Amino Acids, Branched-Chain; Ammonia; Bromocriptine; Dietary Proteins; Hepatic Encephalopathy; Human | 1986 |
The diagnosis and prevalence of subclinical hepatic encephalopathy in apparently healthy, ambulant, non-shunted patients with cirrhosis.
Topics: Ammonia; Electroencephalography; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Liver Cirrhosis, A | 1986 |
[Therapeutic efficacy of vancomycin hydrochloride, a nonabsorbable antibiotic, on intractable (lactulose resistant) chronic hepatic encephalopathy in cirrhotic patients].
Topics: Aged; Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Male; Middle Aged; Vancomycin | 1986 |
Cerebrospinal fluid gamma-aminobutyric acid levels in dogs with chronic portosystemic encephalopathy.
Topics: Ammonia; Animals; Dogs; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Tryptophan | 1986 |
A non-absorbable rifamycin for treatment of hepatic encephalopathy.
Topics: Absorption; Adult; Aged; Ammonia; Colon; Female; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Ma | 1985 |
Visual evoked potential recordings in hepatic encephalopathy and their variations during branched chain amino-acid treatment.
Topics: Adult; Aged; Amino Acids, Branched-Chain; Ammonia; Ethanolamines; Evoked Potentials, Visual; Female; | 1985 |
Disruption of the blood-brain barrier in hyperammonemic coma and the pharmacologic effects of dexamethasone and difluoromethyl ornithine.
Topics: Acetates; Ammonia; Animals; Blood-Brain Barrier; Coma; Dexamethasone; Eflornithine; Exploratory Beha | 1985 |
The effect of dietary protein on nitrogen and sulfur metabolism in portacaval-shunted rats.
Topics: Amino Acids, Sulfur; Ammonia; Animals; Body Weight; Dietary Proteins; Hepatic Encephalopathy; Liver; | 1986 |
Hepatic encephalopathy.
Topics: Ammonia; Brain; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans | 1986 |
[A comparative study of free amino acid levels in the serum and cerebral cortex in hepatic failure rats].
Topics: Acute Disease; Amino Acids; Ammonia; Animals; Blood-Brain Barrier; Carbon Tetrachloride; Cerebral Co | 1986 |
Lactitol in the treatment of chronic hepatic encephalopathy: an open comparison with lactulose.
Topics: Adult; Ammonia; Cerebrovascular Circulation; Chronic Disease; Disaccharides; Electroencephalography; | 1985 |
[Hepatic encephalopathic syndrome in the dog and its treatment].
Topics: Amino Acids; Ammonia; Animals; Dog Diseases; Dogs; Female; Hepatic Encephalopathy; Male | 1985 |
[Congenital hepatic fibrosis disclosed late by hepatic encephalopathy].
Topics: Ammonia; Confusion; Female; Hepatic Encephalopathy; Humans; Liver; Liver Diseases; Middle Aged; Time | 1985 |
Cerebral acetylcholine and energy metabolism changes in acute ammonia intoxication in the lower primate Tupaia glis.
Topics: Acetates; Acetylcholine; Ammonia; Animals; Brain; Brain Stem; Coma; Energy Metabolism; Female; Hepat | 1985 |
Serum gamma-aminobutyric acid (GABA) levels in patients with hepatic encephalopathy.
Topics: Ammonia; Chronic Disease; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Kidney Failure, C | 1985 |
[Clinical significance of anaerobic gram-negative bacteria in hepatic encephalopathy and the therapeutic effects of vancomycin hydrochloride on hepatic encephalopathy].
Topics: Aged; Ammonia; Feces; Gram-Negative Anaerobic Bacteria; Hepatic Encephalopathy; Humans; Male; Middle | 1985 |
Successful treatment of hepatic coma by a new artificial liver device in the pig.
Topics: Adenine Nucleotides; Ammonia; Animals; Artificial Organs; Female; Hemoperfusion; Hepatic Encephalopa | 1985 |
[Ambulatory diagnosis and therapy control of portasystemic encephalopathy in patients with liver cirrhosis].
Topics: Aged; Ammonia; Female; Hepatic Encephalopathy; Humans; Hypertension, Portal; Lactulose; Liver Cirrho | 1985 |
[Evaluation of blood ammonia level in liver diseases].
Topics: Acute Disease; Alanine Transaminase; Alkaline Phosphatase; Ammonia; Aspartate Aminotransferases; Bil | 1970 |
[Physiopathological and clinical significance of the most important laboratory findings in hepatitis and cirrhosis].
Topics: Alanine Transaminase; Ammonia; Aspartate Aminotransferases; Bilirubin; Biopsy; Blood Proteins; gamma | 1970 |
Diabetes with liver failure.
Topics: Ammonia; Diabetes Complications; Hepatic Encephalopathy; Humans; Kidney | 1972 |
Ammonia-induced coma after ureterosigmoidostomy.
Topics: Ammonia; Colon, Sigmoid; Hepatic Encephalopathy; Humans; Ureter; Urinary Diversion | 1972 |
Reye's syndrome due to a novel protein-tolerant variant of ornithine-transcarbamylase deficiency.
Topics: Ammonia; Brain Diseases; Child; Fatty Liver; Female; Hepatic Encephalopathy; Humans; Kinetics; Liver | 1974 |
[Therapy of acute liver insufficiency (author's transl)].
Topics: Ammonia; Animals; Blood Circulation; Blood Coagulation Disorders; Cross Circulation; Exchange Transf | 1974 |
[Activities of intrahepatic ammonia detoxication enzymes in hepatic coma].
Topics: Ammonia; Arginase; Arginine; Glutamate-Ammonia Ligase; Hepatic Encephalopathy; Humans; Ligases; Live | 1973 |
Inhibition by acetohydroxamic acid of human mucosal and faecal urease-specific activity.
Topics: Ammonia; Animals; Blood; Colon; Enzymes; Feces; Gastric Mucosa; Hepatic Encephalopathy; Humans; Hydr | 1966 |
Milk-and-cheese diet in portal-systemic encephalopathy.
Topics: Adolescent; Ammonia; Animals; Blood; Brain Diseases; Cheese; Diet Therapy; Dietary Proteins; Female; | 1966 |
Bio-artificial liver: a combined system of hemodialysis and baboon liver perfusion.
Topics: Adolescent; Ammonia; Animals; Arm; Arteriovenous Shunt, Surgical; Bilirubin; Blood Glucose; Brachial | 1973 |
[Parenchymatous organs, hematopoietic system].
Topics: Ammonia; Anemia; Blood Coagulation Disorders; Brain; Brain Diseases; Brain Edema; Cerebral Hemorrhag | 1971 |
[Neurologic complications of liver diseases].
Topics: Ammonia; Antigen-Antibody Reactions; Blood Coagulation Disorders; Brain Edema; Central Nervous Syste | 1971 |
Effects of a treatment with coenzyme A, alpha-lipoic acid, diphosphopyridine nucleotide and cocarboxylase on endogenous hepatic coma.
Topics: Adolescent; Adult; Aged; Ammonia; Bilirubin; Biopsy; Blood Coagulation Factors; Blood Coagulation Te | 1967 |
[The neuro-psychic complications of chronic alcoholism].
Topics: Adolescent; Adult; Aged; Alcoholism; Ammonia; Brain; Brain Chemistry; Chronic Disease; Citric Acid C | 1968 |
[Hepatic coma in cirrhosis].
Topics: Ammonia; Blood Transfusion; Chemical and Drug Induced Liver Injury; Chlorine; Diagnosis, Differentia | 1969 |
[Current views on the therapy of hepatic coma].
Topics: Acute Kidney Injury; Adolescent; Amino Acids; Ammonia; Anti-Bacterial Agents; Arginine; Aspartic Aci | 1970 |
[Action of arginine in a recurrent hepatic coma complicating a feminizing tumor of the adrenal cortex with hepatic metastases].
Topics: Adolescent; Adrenal Gland Neoplasms; Ammonia; Arginine; Estrogens; Feminization; Hepatic Encephalopa | 1973 |
The astrocyte response in experimental portal-systemic encephalopathy: an electron microscopic study.
Topics: Ammonia; Animals; Cell Membrane; Cell Nucleus; Cerebral Cortex; Cytoplasm; Cytoplasmic Granules; Dis | 1974 |
Synergism between ammonia and fatty acids in the production of coma: implications for hepatic coma.
Topics: Ammonia; Animals; Caproates; Caprylates; Cats; Dose-Response Relationship, Drug; Drug Synergism; Fat | 1974 |
[Letter: Hepatic encephalopathy].
Topics: Ammonia; Catecholamines; Hepatic Encephalopathy; Humans; Portacaval Shunt, Surgical | 1974 |
Neurologic changes in liver disease.
Topics: Ammonia; Astrocytes; Brain Diseases; Cerebral Cortex; Copper; Hepatic Encephalopathy; Hepatolenticul | 1974 |
Alpha-ketoglutaramate in hepatic encephalopathy.
Topics: Amides; Ammonia; Animals; Brain; Electroencephalography; Glutamates; Hepatic Encephalopathy; Humans; | 1974 |
Experimental acute hepatic encephalopathy: comparison of the electroencephalographic changes in the liverless and in the eviscerated rat.
Topics: Ammonia; Animals; Behavior, Animal; Cold Temperature; Electrodes, Implanted; Electroencephalography; | 1974 |
Acute hepatic encephalopathy in the rat: the effect of cross-circulation.
Topics: Ammonia; Animals; Aorta; Blood Flow Velocity; Blood Pressure; Catheterization; Cross Circulation; El | 1974 |
Comparative study of basal arterial ammonemia and of orally-induced hyperammonemia in chronic portal systemic encephalopathy, treated with neomycin, lactulose, and an association of neomycin and lactulose.
Topics: Ammonia; Blood Urea Nitrogen; Brain Diseases; Chlorides; Chronic Disease; Disaccharides; Drug Therap | 1974 |
Discriminative and prognostic signs in acute hepatic coma, treated by exchange transfusions.
Topics: Acute Disease; Adolescent; Adult; Alanine Transaminase; Ammonia; Aspartate Aminotransferases; Autops | 1974 |
A cause of hepatic encephalopathy after portacaval shunt.
Topics: Ammonia; Animals; Ascites; Blood Pressure; Dogs; Female; Hepatic Encephalopathy; Intestinal Absorpti | 1974 |
Preliminary studies with acid enemas and their effect on hepatic coma.
Topics: Adult; Ammonia; Carbohydrates; Enema; Female; Hepatic Encephalopathy; Humans; Hydrogen-Ion Concentra | 1974 |
[Hepatic coma in patients with chronic diseases of the liver and its treatment].
Topics: Adolescent; Adult; Ammonia; Female; Hepatic Encephalopathy; Humans; Liver Diseases; Liver Transplant | 1973 |
[Study of glucose tolerance in hepatic coma].
Topics: Ammonia; Fatty Liver; Glucose Tolerance Test; Hepatic Encephalopathy; Humans; Insulin; Liver Cirrhos | 1974 |
[Behavior of ammonia in cirrhosis and hepatic coma].
Topics: Acute Disease; Ammonia; Chronic Disease; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Neurologic | 1972 |
[Effects of arginine malate in experimental and clinical hyperammonemia].
Topics: Adult; Aged; Ammonia; Ammonium Chloride; Animals; Arginine; Brain Diseases; Female; Hepatic Encephal | 1972 |
[Absorption of ammonia from the circulating blood].
Topics: Ammonia; Animals; Blood Circulation; Extracorporeal Circulation; Hepatic Encephalopathy; Humans; Liv | 1972 |
Lactulose enemas.
Topics: Aged; Ammonia; Cathartics; Enema; Feces; Female; Hepatic Encephalopathy; Humans; Hydrogen-Ion Concen | 1973 |
Extracorporeal assist of anhepatic animals with liver slice perfusion.
Topics: Ammonia; Animals; Bilirubin; Carotid Arteries; Electroencephalography; Hepatectomy; Hepatic Encephal | 1973 |
Extracorporeal cation-exchange circuits in the treatment of hyperammonaemia of hepatic failure.
Topics: Adult; Ammonia; Calcium; Child; Female; Hepatic Encephalopathy; Humans; Ion Exchange Resins; Magnesi | 1973 |
Hepatic coma in cirrhosis of the liver. The course and prognosis of 100 consecutive coma episodes.
Topics: Aged; Alkaline Phosphatase; Ammonia; Aspartate Aminotransferases; Bicarbonates; Bilirubin; Chlorides | 1973 |
Lactulose in the treatment of acute hepatic encephalopathy.
Topics: Acute Disease; Ammonia; Connecticut; Dietary Proteins; Evaluation Studies as Topic; Hepatic Encephal | 1973 |
Proceedings: experimental hepatic coma and lethal barbiturate intoxication response to total-body asanguineous hypothermic perfusion in dogs.
Topics: Ammonia; Animals; Dogs; Hepatic Encephalopathy; Hypothermia, Induced; Injections, Intravenous; Perfu | 1973 |
Alpha-ketoglutaramate, a neurotoxic agent in hepatic coma.
Topics: Ammonia; Animals; Cerebral Cortex; Glutamates; Glutamine; Hepatic Encephalopathy; Humans; Ketoglutar | 1973 |
Synergism between mercaptans and ammonia or fatty acids in the production of coma: a possible role for mercaptans in the pathogenesis of hepatic coma.
Topics: Ammonia; Animals; Caprylates; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Drug Synergism; | 1974 |
Alpha-ketoglutaramate: increased concentrations in the cerebrospinal fluid of patients in hepatic coma.
Topics: Amides; Ammonia; Animals; Depression, Chemical; Dose-Response Relationship, Drug; Glutamates; Glutam | 1974 |
Role of urea in the hyperammonemia of germ-free Eck fistula dogs.
Topics: Ammonia; Animals; Blood Urea Nitrogen; Digestive System; Dogs; Female; Germ-Free Life; Hepatic Encep | 1974 |
Brain histology and behavior of mice injected with urease.
Topics: Ammonia; Animals; Behavior, Animal; Body Temperature; Brain; Brain Chemistry; Cell Nucleus; Disease | 1974 |
[Therapy of experimental and clinical hyperammonaemia with ornithine-alpha-ketoglutarate].
Topics: Amino Acids, Dicarboxylic; Ammonia; Animals; Drug Evaluation; Female; Hepatic Encephalopathy; Humans | 1974 |
An experimental model for the study of hepatic encephalopathy.
Topics: Ammonia; Animals; Bilirubin; Blood Glucose; Cell Nucleolus; Cell Nucleus; Cerebral Cortex; Disease M | 1974 |
Alpha-ketoglutarmate, glutamate antagonism and GABA depletion--clues to the pathogenesis of hepatic encephalopathy?
Topics: Amides; Aminobutyrates; Ammonia; Animals; Brain Chemistry; Excitatory Amino Acid Antagonists; Hepati | 1974 |
Milk protein in the treatment of chronic portasystemic encephalopathy. A long-term study of therapeutic measures in a patient with chronic porta-systemic encephalopathy.
Topics: Aged; Ammonia; Animals; Chronic Disease; Diet Therapy; Dogs; Electroencephalography; Hepatic Encepha | 1974 |
Medium chain triglycerides and hepatic encephalopathy.
Topics: Ammonia; Caproates; Chlorpromazine; Electroencephalography; Fatty Acids; Hepatic Encephalopathy; Hum | 1974 |
Disposable organ chamber for perfusion of the ex vivo liver and its use in the treatment of hepatic coma.
Topics: Adult; Ammonia; Animals; Disposable Equipment; Extracorporeal Circulation; Female; Hepatic Encephalo | 1974 |
[Survival duration and prognosis for patients with hepatic coma].
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Middle Aged; Prognosis | 1966 |
[Changes in blood acid-base equilibrium in hepatic coma. Study of their mechanism and of the intervention of alkalosis in ammonia toxicity].
Topics: Alkalosis; Ammonia; Carbon Dioxide; Hepatic Encephalopathy; Humans; Hydrogen-Ion Concentration | 1966 |
The management of hepatic coma: A continuing problem.
Topics: Ammonia; Animals; Hepatic Encephalopathy; History, 17th Century; History, 19th Century; Humans; Hydr | 1968 |
Treatment of hepatic coma.
Topics: Adult; Ammonia; Ascites; Diet Therapy; Dietary Proteins; Exchange Transfusion, Whole Blood; Glutamat | 1969 |
[Importance of hyperammoniemia of the renal origin in the pathogenesis of hepatic coma released in cirrhotic patients by diuretics generating hypokaliemia].
Topics: Acetazolamide; Acid-Base Equilibrium; Alkalosis; Ammonia; Ascites; Chlorides; Chlorthalidone; Edema; | 1969 |
[Subthalamotomy inhibiting the appearance of uremic "flapping tremor"].
Topics: Aged; Ammonia; Electromyography; Extrapyramidal Tracts; Functional Laterality; Hepatic Encephalopath | 1970 |
Lactobacillus acidophilus (enpac) in treatment of hepatic encephalopathy.
Topics: Adult; Aged; Ammonia; Blood; Electroencephalography; Feces; Female; Hepatic Encephalopathy; Humans; | 1966 |
Massive liver necrosis in the monkey: the effects of exchange blood transfusions on fulminant liver failure.
Topics: Ammonia; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical and Drug Ind | 1969 |
Protective effects of arginine against hepatic coma, insulin shock and epilepsy.
Topics: Ammonia; Animals; Arginine; Brain Chemistry; Epilepsy, Absence; Hepatic Encephalopathy; Hypoglycemia | 1969 |
[Comparative study of portocaval encephalopathy treatment with lactulose, lactobacilli and antibiotics].
Topics: Ammonia; Anti-Bacterial Agents; Biological Products; Disaccharides; Electroencephalography; Hepatic | 1971 |
Neurologic disorders and liver disease.
Topics: Adipose Tissue; Ammonia; Brain Diseases; Citrulline; Fatty Liver; Galactosemias; Hepatic Encephalopa | 1971 |
Successful treatment of hepatic coma by exchange transfusions.
Topics: Adult; Ammonia; Bilirubin; Exchange Transfusion, Whole Blood; Female; Hepatic Encephalopathy; Humans | 1967 |
Reye's syndrome: relation of outcome to therapy.
Topics: Adipose Tissue; Ammonia; Child; Child, Preschool; Dexamethasone; Enema; Exchange Transfusion, Whole | 1972 |
[Hepatic coma: physiopathology of ammonia intoxication].
Topics: Ammonia; Hepatic Encephalopathy; Humans | 1972 |
[Discontinuous and continuous determination of blood ammonia by an automatic dialysis technique].
Topics: Amino Acids; Ammonia; Autoanalysis; Chromatography, Ion Exchange; Colorimetry; Dialysis; Evaluation | 1972 |
[Therapy of hyperammonemia: effect of a preparation arginine pyrrolidonecarboxylate, taurine, vitamin B6 and citric acid].
Topics: Amino Acids; Ammonia; Arginine; Brain Diseases; Citrates; Drug Combinations; Hepatic Encephalopathy; | 1972 |
[Hepatogenic hyperammonemia].
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver | 1972 |
[Hepatic coma and ureterosigmoidostomy].
Topics: Aged; Ammonia; Colon, Sigmoid; Hepatic Encephalopathy; Humans; Male; Ureter; Urinary Bladder Neoplas | 1972 |
Toward an artificial liver: in vitro removal of unbound and protein-bound plasma compounds related to hepatic failure.
Topics: Ammonia; Artificial Organs; Bilirubin; Butyrates; Carbon Isotopes; Filtration; Glutamine; Hepatic En | 1972 |
Acute hepatic coma: a canine model.
Topics: Ammonia; Animals; Aspartate Aminotransferases; Blood Coagulation Tests; Blood Pressure; Blood Urea N | 1972 |
Levodopa in hepatic failure.
Topics: Ammonia; Dihydroxyphenylalanine; Dopamine; Hepatic Encephalopathy; Humans; Male; Middle Aged; Norepi | 1972 |
[Therapy of severe hyperammonemia].
Topics: Adult; Aged; Ammonia; Anti-Bacterial Agents; Aspartic Acid; Diet Therapy; Enzyme Induction; Female; | 1972 |
Liver efficiency of patients treated with extracorporeal perfusion because of coma complicating viral hepatitis. Biochemical and coagulological studies.
Topics: Acute Disease; Alanine Transaminase; Ammonia; Aspartate Aminotransferases; Bilirubin; Blood Coagulat | 1972 |
Treatment of chronic portal-systemic encephalopathy with lactulose. Report of six patients and review of the literature.
Topics: Aged; Ammonia; Brain Diseases; Cathartics; Chronic Disease; Colon; Diarrhea; Dietary Proteins; Disac | 1971 |
Influence of non-protein nitrogen substances on the indophenol reaction.
Topics: Amino Acids; Ammonia; Chemistry, Clinical; Diagnosis, Differential; Hepatic Encephalopathy; Humans; | 1971 |
Pig-liver perfusion. Extracorporeal pig-liver perfusion in a patient with acute hepatic failure.
Topics: Adult; Ammonia; Anesthesia, Inhalation; Animals; Autopsy; Bilirubin; Biopsy; Embolism; Female; Halot | 1971 |
Tryptophan metabolism in liver disease.
Topics: Adult; Aged; Amino Acids; Ammonia; Brain Diseases; Chronic Disease; Diabetes Complications; Diabetes | 1971 |
The CSF in hepatic encephalopathy.
Topics: Acid-Base Equilibrium; Ammonia; Bicarbonates; Bilirubin; Cerebrospinal Fluid Proteins; Glutamates; G | 1971 |
Introduction: pathogenetic problems and classification of neuropsychic disturbances.
Topics: Alkalosis; Amino Acids; Aminobutyrates; Ammonia; Brain; Calcium; Consciousness; Glutamine; Hepatic E | 1971 |
Brain energy metabolism in hepatic coma.
Topics: Ammonia; Brain; Brain Diseases; Carbon Dioxide; Carbon Isotopes; Cerebrovascular Circulation; Glucos | 1971 |
Cerebral ammonia metabolism and hepatic coma.
Topics: Adenosine Triphosphate; Alkalosis; Ammonia; Brain; Hepatic Encephalopathy; Humans; Ketoglutarate Deh | 1971 |
Cerebral amino acid metabolism in hepatic coma.
Topics: Amino Acids; Aminobutyrates; Ammonia; Aspartic Acid; Brain; Cerebral Cortex; Electroencephalography; | 1971 |
[Value of blood ammonia determinations in severe jaundices].
Topics: Adolescent; Adult; Aged; Ammonia; Arginine; Child; Child, Preschool; Chlortetracycline; Female; Gluc | 1971 |
[The so called hepatic encephalopathy. Pathophysiology and diagnosis].
Topics: Alcoholic Intoxication; Ammonia; Atrophy; Brain; Brain Diseases; Electroencephalography; Hepatic Enc | 1971 |
Surgical treatment of chronic portal-systemic encephalopathy.
Topics: Ammonia; Colectomy; Female; Hepatic Encephalopathy; Humans; Mental Disorders; Middle Aged; Portacava | 1968 |
Blood ammonia in liver diseases and hepatic coma.
Topics: Adolescent; Adult; Ammonia; Hepatic Encephalopathy; Humans; Liver Diseases; Middle Aged | 1968 |
Insulin and glucose metabolism in liver cirrhosis and in liver failure.
Topics: Adult; Aged; Ammonia; Blood Glucose; Female; Glucose; Glucose Tolerance Test; Hepatic Encephalopathy | 1970 |
Recurrent hepatic coma following ureterosigmoidostomy.
Topics: Acidosis; Adolescent; Aged; Ammonia; Chlorides; Chronic Disease; Colon, Sigmoid; Female; Hepatic Enc | 1970 |
Heterologous liver perfusion in acute hepatic failure.
Topics: Acid-Base Equilibrium; Acute Kidney Injury; Adult; Ammonia; Animals; Bilirubin; Blood Coagulation Di | 1967 |
[Effects of the arginine-ornithine combination on the arterial ammonia levels in chronic liver diseases and hepatic coma].
Topics: Ammonia; Arginine; Chronic Disease; Hepatic Encephalopathy; Humans; Methods; Ornithine; Uremia | 1968 |
[Determination of blood ammonia levels as a routine test in the clinical laboratory].
Topics: Ammonia; Colorimetry; Gastrointestinal Hemorrhage; Hepatic Encephalopathy; Hepatitis; Humans; Liver | 1966 |
[Methods and clinical significance of femin ammonia determination].
Topics: Ammonia; Clinical Enzyme Tests; Digestive System; Esophageal and Gastric Varices; Gastrointestinal H | 1970 |
Precipitating factors in genesis of hepatic coma.
Topics: Acute Kidney Injury; Ammonia; Diuretics; Female; Gastrointestinal Hemorrhage; Hepatic Encephalopathy | 1970 |
Acute hepatic coma treated by cross circulation with irreversibly comatose donor.
Topics: Acute Disease; Adult; Ammonia; Aspartate Aminotransferases; Bilirubin; Blood Donors; Brain Death; Br | 1970 |
A rational program for the management of hepatic coma.
Topics: Alkalosis; Ammonia; Dietary Proteins; Hepatic Encephalopathy; Humans; Nitrogen | 1969 |
Acid-base and electrolyte disturbances in hepatic coma.
Topics: Acid-Base Equilibrium; Adult; Alkalosis; Ammonia; Electrolytes; Female; Hepatic Encephalopathy; Huma | 1969 |
A case of recurrent hepatic coma combined with hemiplegia.
Topics: Aged; Ammonia; Chronic Disease; Hemiplegia; Hepatic Encephalopathy; Humans; Male | 1969 |
[Protein metabolism and detoxification in liver insufficiency].
Topics: Ammonia; Anti-Bacterial Agents; Brain; Endotoxins; Hepatic Encephalopathy; Humans; Liver Cirrhosis; | 1969 |
Ammonia production in the human colon. Effects of cleansing, neomycin and acetohydroxamic acid.
Topics: Adult; Ammonia; Colon; Feces; Female; Hepatic Encephalopathy; Humans; Hydroxamic Acids; Intestinal A | 1970 |
Massive exchange transfusions in hepatic coma with recovery.
Topics: Adult; Ammonia; Bilirubin; Blood Chemical Analysis; Exchange Transfusion, Whole Blood; Hepatic Encep | 1970 |
Pathogenesis of hepatic encephalopathy--with special reference to the role of ammonia.
Topics: Adenosine Triphosphate; Amino Acids; Ammonia; Animals; Brain; Electroencephalography; Fatty Acids; G | 1970 |
Ammonia metabolism in the gut.
Topics: Ammonia; Digestive System; Hepatic Encephalopathy; Humans; Intestinal Absorption; Liver Cirrhosis; U | 1970 |
Early diagnosis of fatal hepatitis.
Topics: Acute Disease; Alanine Transaminase; Ammonia; Aspartate Aminotransferases; Autopsy; Bilirubin; Biops | 1970 |
Hepatic coma: newer pathogenetic and therapeutic factors.
Topics: Amino Acids; Ammonia; Hepatic Encephalopathy; Humans | 1970 |
The distribution of ammonium nitrogen in venous blood, ascites, and cerebrospinal fluid in cases of hepatic cirrhosis.
Topics: Ammonia; Ascitic Fluid; Cerebrospinal Fluid; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Nitrog | 1970 |
[Blood ammonia and acid-base equilibrium during acute atrophy of the liver].
Topics: Acid-Base Equilibrium; Acute Disease; Adult; Alkalosis; Ammonia; Atrophy; Carbon Dioxide; Female; He | 1970 |
[Prevention and therapy of hepatic coma].
Topics: Aged; Amides; Ammonia; Aspartic Acid; Chlorothiazide; Clopamide; Depression, Chemical; Diuretics; Fe | 1970 |
Urease and deaminase activities of fecal bacteria in hepatic coma.
Topics: Administration, Oral; Aminohydrolases; Ammonia; Deamination; Feces; Hepatic Encephalopathy; Humans; | 1970 |
[Determination of plasmatic ammonia concentration by a modified ion exchange method].
Topics: Ammonia; Hepatic Encephalopathy; Humans; Ion Exchange; Ion Exchange Resins; Liver Cirrhosis; Methods | 1970 |
[Experimental studies on the ex-vivo liver perfusion].
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Ammonia; Animals; Aspartate Ami | 1970 |
Glutamine values in cerebrospinal fluid of children: some observations on clinical application.
Topics: Ammonia; Glutamates; Glutamine; Hepatic Encephalopathy; Hepatitis A; Humans; Infant; Infant, Newborn | 1971 |
[Prognostic factors during coma due to acute hepatic atrophy].
Topics: Adolescent; Adult; Aged; Ammonia; Blood Coagulation Tests; Child; Child, Preschool; Fatty Liver; Fem | 1971 |
Exchange transfusion in hepatic coma. A review of 19 cases.
Topics: Adolescent; Adult; Alanine Transaminase; Ammonia; Anesthesia, Inhalation; Autopsy; Bilirubin; Blood | 1971 |
[Physiopathologic bases of treatment of portacaval encephalopathy].
Topics: Ammonia; Brain; Brain Diseases; Hepatic Encephalopathy; Humans; Liver Circulation; Liver Cirrhosis; | 1971 |
Hemodialysis of ammonium nitrogen.
Topics: Ammonia; Animals; Disease Models, Animal; Dogs; Extracorporeal Circulation; Hepatic Encephalopathy; | 1971 |
[8. Clinical and experimental studies on the pathogenesis of portacaval encephalopathy].
Topics: Ammonia; Ammonium Chloride; Blood Pressure; Colectomy; Electroencephalography; Hepatic Encephalopath | 1967 |
[Significance of ammoniemia in epidemic hepatitis].
Topics: Adolescent; Adult; Aged; Ammonia; Cholestasis; Diagnosis, Differential; Glutamine; Hepatic Encephalo | 1967 |
[Treatment of hepatic cirrhosis and hepatic coma with drugs having the capacity of lowering the blood ammonia levels].
Topics: Ammonia; Arginine; Aspartic Acid; Bacteria; Female; Glutamates; Hepatic Encephalopathy; Humans; Live | 1967 |
[Ammonia and glutamine levels in venous blood in epidemic hepatitis complicated by hepatic coma].
Topics: Adolescent; Adult; Aged; Ammonia; Female; Glutamine; Hepatic Encephalopathy; Hepatitis A; Humans; Ma | 1967 |
[Amnoniacal detoxication and cerearal metabolism].
Topics: Acidosis, Respiratory; Ammonia; Brain; Brain Diseases; Coma; Hepatic Encephalopathy; Humans; Liver D | 1967 |
[Recurrent coma with hyperammoniemia and gaseous alkalosis in a patient with a uretero-colonic anastomosis].
Topics: Alkalosis; Ammonia; Colon; Female; Hepatic Encephalopathy; Humans; Hydrogen-Ion Concentration; Intes | 1967 |
Surgical exclusion of the colon for chronic hepatic encephalopathy.
Topics: Ammonia; Chronic Disease; Colon; Dietary Proteins; Follow-Up Studies; Hepatic Encephalopathy; Humans | 1968 |
Effects of urease inhibition in hyperammonemia: clinical and experimental studies with acetohydroxamic acid.
Topics: Aged; Ammonia; Animals; Bilirubin; Budd-Chiari Syndrome; Dogs; Fasting; Female; Hepatic Encephalopat | 1968 |
[Importance of ammonia in the pathogensis of a hepatic comma].
Topics: Adolescent; Adult; Ammonia; Female; Hepatic Encephalopathy; Humans; Liver Diseases; Male | 1968 |
Cirrhosis, hyperammonemia and Lactulose.
Topics: Adult; Aged; Ammonia; Disaccharides; Electroencephalography; Female; Hepatic Encephalopathy; Humans; | 1968 |
The pathogenesis and medical treatment of hepatic encephalopathy.
Topics: Ammonia; Hepatic Encephalopathy; Humans | 1968 |
The effect upon tissue respiration in vitro of metabolites which may accumulate in hepatic coma.
Topics: Ammonia; Animals; Bile; Bile Acids and Salts; Cerebral Cortex; Culture Techniques; Drug Synergism; H | 1968 |
[Treatment with aspartic acid in hepatic coma caused by hyperammonemia].
Topics: Ammonia; Aspartic Acid; Hepatic Encephalopathy; Humans; Liver Cirrhosis | 1968 |
Metabolic buffers in hepatic failure.
Topics: Adenosine Triphosphate; Amino Acids; Ammonia; Animals; Blood Glucose; Blood Urea Nitrogen; Diet Ther | 1968 |
[Extension of indications for portal shunt operation through the management of postoperative liver decompensation with peritoneal dialysis].
Topics: Adult; Ammonia; Bilirubin; Esophageal and Gastric Varices; Female; Hepatic Encephalopathy; Humans; H | 1968 |
[On the action mechanism of lactulose in hepatic coma--clarification of colon urease activity using C-14 urea in rats].
Topics: Ammonia; Animals; Carbon Dioxide; Carbon Isotopes; Colon; Disaccharides; Feces; Hepatic Encephalopat | 1968 |
[Hepatic coma. Biochemical aspects, physiopathology and treatment].
Topics: Ammonia; Hepatic Encephalopathy; Humans; Neurotic Disorders | 1968 |
[Ammonia intoxication in cirrhotics].
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Liver Function Tests; Portacaval Shunt, Su | 1968 |
[Application of the blood direct measurement of blood ammonia as a clinical test].
Topics: Ammonia; Colorimetry; Female; Hepatic Encephalopathy; Humans; Kidney Diseases; Male; Methods; Spectr | 1968 |
[72 cases of hepatic coma. Trial clinical, biological and anatomical correlation apropos of 105 cases].
Topics: Adult; Aged; Ammonia; Brain; Electroencephalography; Female; Hepatic Encephalopathy; Humans; Male; M | 1968 |
Renal tubular acidosis in cirrhosis. A determinant of susceptibility to recurrent hepatic precoma.
Topics: Acidosis, Renal Tubular; Ammonia; Ammonium Chloride; Blood Urea Nitrogen; Calcium; Calcium Chloride; | 1969 |
[Therapy of hyperammoniemia].
Topics: Adenosine Triphosphate; Ammonia; Anti-Bacterial Agents; Arginine; Aspartic Acid; Citrulline; Dietary | 1969 |
Total body composition in cirrhotic patients with metabolic alkalosis, hypokalemia, hyperammoniemia, and portacaval shunt.
Topics: Alkalosis; Ammonia; Body Composition; Hepatic Encephalopathy; Humans; Hydrogen-Ion Concentration; Hy | 1969 |
The biochemistry of hepatic failure.
Topics: Acute Kidney Injury; Ammonia; Animals; Ascites; Blood Glucose; Carbohydrate Metabolism; Dogs; Hepati | 1969 |
[Hepatic depuration with heterologous liver. Physiopathological presuppositions, indications and metabolic and hemodynamic characteristics of the experimental preparation].
Topics: Ammonia; Animals; Glucose; Hemodynamics; Hepatic Encephalopathy; Liver; Liver Circulation; Liver Dis | 1969 |
Cerebrospinal fluid glutamine concentration in patients with chronic hypercapnia.
Topics: Adult; Aged; Ammonia; Chronic Disease; Female; Glutamine; Hepatic Encephalopathy; Humans; Hydrogen-I | 1969 |
[Severe hepatic insufficiency: hepatic coma and the precoma].
Topics: Ammonia; Hepatic Encephalopathy; Humans | 1969 |
[Heterologous pig liver perfusion in hepatic coma].
Topics: Adult; Ammonia; Bilirubin; Colitis, Ulcerative; Female; Hepatic Encephalopathy; Humans; Lactates; Li | 1969 |
Reye's syndrome: ammonia intoxication as a possible factor in the encephalopathy.
Topics: Adolescent; Ammonia; Brain Diseases; Child; Child, Preschool; Coma; Dermatitis; Fatty Liver; Female; | 1969 |
Hepatic coma due to fulminating hepatitis treated with extracorporeal pig-liver perfusion.
Topics: Alkaline Phosphatase; Ammonia; Animals; Bilirubin; Hepatic Encephalopathy; Hepatitis; Humans; Liver; | 1969 |
[Treatment of comatose patients with the artificial kidney].
Topics: Adult; Ammonia; Female; Hepatic Encephalopathy; Humans; Jaundice; Kidneys, Artificial; Liver Cirrhos | 1969 |
Ammonia metabolism.
Topics: Ammonia; Brain Diseases; Hepatic Encephalopathy; Humans | 1964 |
Blood ammonia.
Topics: Ammonia; Blood; Hepatic Encephalopathy; History, 19th Century; History, 20th Century; Humans | 1965 |
Evaluation of blood exchange in the treatment of Hepatic Coma.
Topics: Adult; Ammonia; Animals; Bilirubin; Blood Glucose; Blood Urea Nitrogen; Child; Child, Preschool; Dog | 1966 |
Tryptophan as cause of hepatic coma.
Topics: Ammonia; Animals; Dogs; Hepatic Encephalopathy; Male; Serotonin; Tryptophan | 1966 |
Relation of potassium depletion to renal ammonium metabolism and hepatic coma.
Topics: Adult; Ammonia; Animals; Dogs; Hepatic Encephalopathy; Humans; Kidney; Liver Cirrhosis; Male; Middle | 1966 |
Encephalopathy in graded portacaval shunts.
Topics: Ammonia; Animals; Brain; Dogs; Hepatic Encephalopathy; Neuroglia; Portacaval Shunt, Surgical | 1966 |
Exclusion of the colon for chronic hepatic encephalopathy.
Topics: Adult; Ammonia; Colon; Diet Therapy; Dietary Proteins; Hepatic Encephalopathy; Humans; Ileum; Liver | 1966 |
Treatment of hepatic coma by extracorporeal liver perfusion.
Topics: Adolescent; Adult; Ammonia; Angiography; Animals; Ascites; Bilirubin; Blood Glucose; Chemotherapy, C | 1966 |
[Observations on the determination of ammonia in the blood].
Topics: Ammonia; Blood Chemical Analysis; Hepatic Encephalopathy; Humans | 1966 |
[Pathogenesis and treatment of hepatic coma].
Topics: Ammonia; Animals; Blood Chemical Analysis; Dogs; Hepatic Encephalopathy; Humans; In Vitro Techniques | 1966 |
Differences in ammonia production by faecal bacteria of patients with hepatic encephalopathy.
Topics: Ammonia; Bacillus; Diet Therapy; Feces; Hepatic Encephalopathy; Humans; Neomycin | 1966 |
Hypokalemia-induced hepatic coma in cirrhosis. Occurrence despite neomycin therapy.
Topics: Ammonia; Blood Chemical Analysis; Feces; Hepatic Encephalopathy; Humans; Hypokalemia; In Vitro Techn | 1966 |
[On enzymatic blood ammonia determination in liver patients with and without hepatic coma].
Topics: Adult; Ammonia; Blood Chemical Analysis; Clinical Enzyme Tests; Female; Hepatic Encephalopathy; Hepa | 1966 |
[Symptoms of encephalopathies from the viewpoint of the neurologist].
Topics: Ammonia; Brain; Electroencephalography; Headache; Hepatic Encephalopathy; Humans; Neurologic Manifes | 1966 |
[Amino acid metabolism in encephalopathies with special consideration of hepatic coma].
Topics: Amino Acids; Ammonia; Brain; Brain Chemistry; Brain Diseases; Central Nervous System; Hepatic Enceph | 1966 |