ammonium hydroxide and Acute Disease studies

Research Excerpts

Excerpt	Relevance	Reference
"The efficacy and safety of rifaximin in comparison with lactitol in the treatment of acute hepatic encephalopathy was assessed in a prospective randomized, double-blind, double-dummy, controlled trial."	9.10	Comparison of rifaximin and lactitol in the treatment of acute hepatic encephalopathy: results of a randomized, double-blind, double-dummy, controlled clinical trial. ( Castells, L; Coll, I; Fernández-Rodríguez, C; Mas, A; Pardo, A; Planas, R; Rodés, J; Rodrigo, L; Rodríguez-Martínez, D; Sunyer, L; Vargas, V, 2003)
"In chronic metabolic acidosis in the rat, there is increased ammoniagenesis, gluconeogenesis and renal extraction of glutamine with induction of renal phosphate-dependent glutaminase (PDG)."	8.76	Glutamine metabolism in metabolic acidosis. ( Alleyne, GA; Barnswell, J; Benjamin, J; Hortelano, P; Lupianez, JA; McFarlane-Anderson, N; Scott, B, 1982)
"In propionic aciduria and methylmalonic aciduria, hyperammonemia as a symptom of metabolic decompensation is one of the major clinical problems."	7.76	N-carbamylglutamate in emergency management of hyperammonemia in neonatal acute onset propionic and methylmalonic aciduria. ( Donati, MA; Filippi, L; Fiorini, P; Gozzini, E; la Marca, G; Malvagia, S, 2010)
" Ammonium and glucose productions from glutamine were inversely related to pHe and pHi in tubules from both control and acidotic animals and were higher in acidosis."	7.68	Regulation of glutamine metabolism in dog kidney cortex: effect of pH and chronic acidosis. ( Drewnowska, K; Schoolwerth, AC; Smith, BC, 1992)
"To clarify the changes of vasoactive amines associated with acute hepatic failure, ammonia, tryptophan, serotonin (5-HT) and histamine in the blood and liver were studied in dogs (n = 22) of each three group of acute hepatic ischemia; occlusion of hepatic artery (controls), occlusion of hepatic artery and portal vein (THI), and portocaval shunt with THI (PCS + THI)."	7.67	[Changes in serotonin and histamine levels in blood and liver after acute hepatic ischemia]. ( Furukawa, T; Katsuki, T; Ono, J, 1984)
"Previous studies have shown a rise in arterial glutamine in acute acidosis in the dog."	7.66	Effects of acute metabolic acidosis on renal, gut, liver, and muscle metabolism of glutamine and ammonia in the dog. ( Fine, A, 1982)
"The efficacy and safety of rifaximin in comparison with lactitol in the treatment of acute hepatic encephalopathy was assessed in a prospective randomized, double-blind, double-dummy, controlled trial."	5.10	Comparison of rifaximin and lactitol in the treatment of acute hepatic encephalopathy: results of a randomized, double-blind, double-dummy, controlled clinical trial. ( Castells, L; Coll, I; Fernández-Rodríguez, C; Mas, A; Pardo, A; Planas, R; Rodés, J; Rodrigo, L; Rodríguez-Martínez, D; Sunyer, L; Vargas, V, 2003)
"In chronic metabolic acidosis in the rat, there is increased ammoniagenesis, gluconeogenesis and renal extraction of glutamine with induction of renal phosphate-dependent glutaminase (PDG)."	4.76	Glutamine metabolism in metabolic acidosis. ( Alleyne, GA; Barnswell, J; Benjamin, J; Hortelano, P; Lupianez, JA; McFarlane-Anderson, N; Scott, B, 1982)
"The purpose of the study was to evaluate the influence of establishing a protocol for the use of combined sodium benzoate and sodium phenylacetate (SBSP) (Ammonul®) to treat acute hyperammonemia."	3.91	Influence of implementing a protocol for an intravenously administered ammonia scavenger on the management of acute hyperammonemia in a pediatric intensive care unit. ( Brossier, D; Goyer, I; Jouvet, P; Marquis, C; Mitchell, G; Ozanne, B; Ziani, L, 2019)
" Cyclophosphamide caused hyperammonemia; glutamine/ammonia and urea/ammonia ratios in the blood decreased."	3.78	Aggravation of cyclophosphamide-induced acute neurological disorders under conditions of artificial acidification of chyme in rats. ( Ivnitsky, JJ; Malakhovsky, VN; Rejuniuk, VL; Schaefer, TV, 2012)
"In propionic aciduria and methylmalonic aciduria, hyperammonemia as a symptom of metabolic decompensation is one of the major clinical problems."	3.76	N-carbamylglutamate in emergency management of hyperammonemia in neonatal acute onset propionic and methylmalonic aciduria. ( Donati, MA; Filippi, L; Fiorini, P; Gozzini, E; la Marca, G; Malvagia, S, 2010)
" plantarum strains were administered in ornithine transcarbamoylase-deficient Sparse-fur mice, a model of constitutive hyperammonemia, in a carbon tetrachloride rat model of chronic liver insufficiency and in a thioacetamide-induced acute liver failure mice model."	3.74	Control of acute, chronic, and constitutive hyperammonemia by wild-type and genetically engineered Lactobacillus plantarum in rodents. ( Demetter, P; Devière, J; Goffin, P; Gustot, T; Hols, P; Moreno, C; Nicaise, C; Prozzi, D; Quertinmont, E; Suain, V; Viaene, E, 2008)
"Intracerebral microdialysis was applied to monitor the neocortical extracellular levels of the aromatic amino acids phenylalanine, tyrosine, and tryptophan, the neurotransmitters dopamine (DA), noradrenaline (NA), and serotonin (5-HT), and the metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindole-3-acetic acid (5-HIAA) in rats with various forms of experimental hepatic encephalopathy (HE)."	3.69	Neocortical dialysate monoamines of rats after acute, subacute, and chronic liver shunt. ( Bengtsson, F; Bergqvist, PB; Bosman, DK; Chamuleau, RA; Hjorth, S; Maas, MA; Vogels, BA, 1995)
"The effects of hyperammonemia on brain function have been studied in three different experimental models in the rat: acute liver ischemia, urease-treated animals and methionine sulfoximine-treated animals."	3.68	Changes in brain metabolism during hyperammonemia and acute liver failure: results of a comparative 1H-NMR spectroscopy and biochemical investigation. ( Bosman, DK; Bovée, WM; Chamuleau, RA; De Graaf, AA; Deutz, NE; Jörning, GG; Maas, MA; Van Eijk, HM; vd Hulst, RW, 1990)
" Because both PGF2 alpha- and TPA-induced inhibition of ammoniagenic response to acute acidosis was prevented by amiloride, the underlying mechanism may involve protein kinase C-mediated changes in intracellular pH."	3.68	Signal transduction events whereby PGF2 alpha inhibits the ammoniagenic response to acute acidosis. ( Sahai, A; Sandler, RS; Shayman, JA; Tannen, RL; Xu, G, 1992)
" Ammonium and glucose productions from glutamine were inversely related to pHe and pHi in tubules from both control and acidotic animals and were higher in acidosis."	3.68	Regulation of glutamine metabolism in dog kidney cortex: effect of pH and chronic acidosis. ( Drewnowska, K; Schoolwerth, AC; Smith, BC, 1992)
"To understand the mechanisms that initiate the increase in ammonia formation during acute acidosis in kidney [amino-15N]- and [amino-15N]glutamine were used as substrates in isolated perfused rat kidney experiments."	3.67	Effect of acute metabolic acidosis on ammonia metabolism in kidney. ( Bogusky, RT; Dietrich, RL, 1989)
"To clarify the changes of vasoactive amines associated with acute hepatic failure, ammonia, tryptophan, serotonin (5-HT) and histamine in the blood and liver were studied in dogs (n = 22) of each three group of acute hepatic ischemia; occlusion of hepatic artery (controls), occlusion of hepatic artery and portal vein (THI), and portocaval shunt with THI (PCS + THI)."	3.67	[Changes in serotonin and histamine levels in blood and liver after acute hepatic ischemia]. ( Furukawa, T; Katsuki, T; Ono, J, 1984)
"Previous studies have shown a rise in arterial glutamine in acute acidosis in the dog."	3.66	Effects of acute metabolic acidosis on renal, gut, liver, and muscle metabolism of glutamine and ammonia in the dog. ( Fine, A, 1982)
"Experiments in rabbits were carried out to study the morphology of contractile myocardium in arrhythmias caused by electric stimulation of previously intact myocardium (1st group) and in those caused by inhalation of ammonia steam against the background of exogenous poisoning with barium chloride (2nd group)."	3.66	[Changes in the contractile myocardium in acute rhythm disorders]. ( Demurov, EA; Iudakova, TM; Paukov, VS, 1981)
"Acute hepatic encephalopathy in 70 cirrhotic patients was monitored during parenteral administration of amino acids between January 1979 and January 1984."	2.66	Treatment of acute hepatic encephalopathy in cirrhotics with a branched-chain amino acids enriched versus a conventional amino acids mixture. A controlled study of 70 patients. ( Aubin, JP; Bauret, P; Bellet-Herman, H; Bories, P; Michel, H; Pomier-Layrargues, G, 1985)
"When hyperammonemia is not thought to be the result of liver failure, treatment for an occult disorder of metabolism must begin prior to the confirmation of an etiology."	2.44	Hyperammonemia in the ICU. ( Clay, AS; Hainline, BE, 2007)
"Hyperammonemia is considered to be the main cause of decreased levels of the branched-chain amino acids (BCAA), valine, leucine, and isoleucine, in liver cirrhosis."	1.37	Acute hyperammonemia activates branched-chain amino acid catabolism and decreases their extracellular concentrations: different sensitivity of red and white muscle. ( Holecek, M; Kandar, R; Kovarik, M; Sispera, L, 2011)
"Patients with acute hepatic encephalopathy may exhibit characteristic regions of involvement on FLAIR with DWI findings that can be reversible."	1.36	Acute hepatic encephalopathy: diffusion-weighted and fluid-attenuated inversion recovery findings, and correlation with plasma ammonia level and clinical outcome. ( Brace, JR; Lohman, BD; McKinney, AM; Sarikaya, B; Singewald, T; Spanbauer, J; Uhlmann, E, 2010)
"An acute confusional state occurred in more than half the patients with transplantation for alcoholic liver disease."	1.31	Acute confusional state following liver transplantation for alcoholic liver disease. ( Buis, CI; Kremers, WK; Krom, RA; Wiesner, RH; Wijdicks, EF, 2002)
"Extracorporeal liver perfusion in hepatic coma, used to eliminate toxic metabolites causing hepatic encephalopathy, is limited by the antibody (Ab) and complement-mediated hyperacute rejection of discordant xenografts."	1.30	Application of immunoapheresis for delaying hyperacute rejection during isolated xenogeneic pig liver perfusion. ( Hammer, C; Hoebel, G; Mueller-Derlich, J; Pascher, A; Poehlein, C; Stangl, M; Thiery, J, 1997)
"An acute proctocolitis was found at sigmoidoscopy in both patients."	1.30	Acute colitis caused by caustic products. ( Brito, MJ; da Fonseca, J; Freitas, J; Leal, C, 1998)
"Cerebral edema leading to cerebral herniation (CH) is a common cause of death in acute liver failure (ALF)."	1.30	Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration. ( Clemmesen, JO; Hansen, BA; Kondrup, J; Larsen, FS; Ott, P, 1999)
"Patients with severe acute alcoholic hepatitis develop multiple organ failure which is associated with production of inflammatory cytokines and a poor prognosis."	1.30	Temporary extracorporeal liver support for severe acute alcoholic hepatitis using the BioLogic-DT. ( Ellis, AJ; Hughes, RD; Langley, PG; Nicholl, D; O'Grady, JG; Wendon, JA; Williams, R, 1999)
"An unusual case of acute cerebral edema as part of the syndrome of portal systemic encephalopathy in an individual with established chronic liver disease is reported."	1.29	Acute cerebral edema as part of the syndrome of hepatic encephalopathy in an individual with chronic liver disease: a case report. ( Jabbour, N; Karavias, D; Van Thiel, DH, 1994)
"Acute liver failure was induced by a two-stage devascularization procedure."	1.29	Neuronal and glial marker proteins in encephalopathy associated with acute liver failure and acute hyperammonemia in the rabbit. ( de Knegt, RJ; Ding, M; Groeneweg, M; Haglid, KG; Hamberger, A; Schalm, SW; Wang, S, 1993)
"Hepatic encephalopathy was induced by a two-stage liver devascularization procedure and acute hyperammonemia by a prolonged ammonium-acetate infusion; rabbits receiving a sodium-potassium-acetate infusion served as controls."	1.29	Binding of the ligand [3H]MK-801 to the MK-801 binding site of the N-methyl-D-aspartate receptor during experimental encephalopathy from acute liver failure and from acute hyperammonemia in the rabbit. ( de Knegt, RJ; Kornhuber, J; Riederer, P; Rusche, K; Schalm, SW; Tan, J, 1993)
"Two experimental models of hepatic encephalopathy in the rat have been investigated in order to study the postulated relationship between plasma free fatty acids concentration (C6 - C22:0) and the degree of hepatic encephalopathy."	1.28	The relationship between plasma free fatty acids and experimentally induced hepatic encephalopathy in the rat. ( Bosman, DK; Chamuleau, RA; de Haan, JG; Jörning, GG; Maas, MA; Smit, JJ, 1991)
"The patient had a brother with OTC deficiency who had died of hyperammonemia at 17 years of age."	1.28	[Abrupt onset and rapid deterioration in the course of congenital ornithine transcarbamylase deficiency: a case report]. ( Fujimoto, K; Fukuizumi, H; Ishibashi, H; Kudo, J; Kumashiro, T; Niho, Y; Shimamura, R; Taniyama, T, 1990)
"Acute respiratory alkalosis (blood pH, 7."	1.27	Renal metabolism and ammoniagenesis during acute respiratory alkalosis in the dog. ( Cardoso, M; Duplain, M; Gougoux, A; Vinay, P, 1984)
"During the initial high pH period, respiratory alkalosis had no effect on NH3 production in comparison with perfusions at a normal pH."	1.27	Response of ammoniagenesis to acute alkalosis. ( Goyal, M; Tannen, RL, 1984)
"Chronic alkalosis was induced by chloride restriction and the administration of sodium bicarbonate and furosemide."	1.27	Renal tubular biochemistry during acute and chronic metabolic alkalosis in the dog. ( Aranda, MR; Ibanez, RJ; Kiss, AL; Lemieux, C; Lemieux, G, 1985)
"Acute metabolic acidosis was induced by an i."	1.26	Changes in renal metabolite profile and ammoniagenesis during acute and chronic metabolic acidosis in dog and rat. ( Allignet, E; Gougoux, A; Lemieux, G; Pichette, C; Vinay, P; Watford, M, 1980)
"Respiratory acidosis is due to alveolar hypoventilation."	1.26	Acute acid-base disorders. 2. Specific disturbances. ( Quintanilla, AP, 1976)

Research

Studies (172)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Change in Ammonia

Timeframe	Studies, this research(%)	All Research%
pre-1990	103 (59.88)	18.7374
1990's	36 (20.93)	18.2507
2000's	19 (11.05)	29.6817
2010's	14 (8.14)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Mekky, MA	1
Riad, AR	1
Gaber, MA	1
Abdel-Malek, MO	1
Swifee, YM	1
Martinelli, D	1
Goffredo, BM	1
Falvella, FS	1
Marano, M	1
Brossier, D	1
Goyer, I	1
Ziani, L	1
Marquis, C	1
Mitchell, G	1
Ozanne, B	1
Jouvet, P	1
Jayakumar, AR	2
Tong, XY	1
Curtis, KM	1
Ruiz-Cordero, R	1
Abreu, MT	1
Norenberg, MD	3
Rama Rao, KV	2
Nicaise, C	1
Prozzi, D	1
Viaene, E	1
Moreno, C	1
Gustot, T	1
Quertinmont, E	1
Demetter, P	1
Suain, V	1
Goffin, P	1
Devière, J	1
Hols, P	1
Gao, XL	1
Wang, J	1
Yuan, SL	1
Tng, YY	1
Chew, SF	1
Wee, NL	1
Wong, FK	1
Wong, WP	1
Tok, CY	1
Ip, YK	1
Filippi, L	1
Gozzini, E	1
Fiorini, P	1
Malvagia, S	1
la Marca, G	1
Donati, MA	1
Kaminsky, Y	1
Kosenko, E	4
McKinney, AM	1
Lohman, BD	1
Sarikaya, B	1
Uhlmann, E	1
Spanbauer, J	1
Singewald, T	1
Brace, JR	1
Holecek, M	1
Kandar, R	1
Sispera, L	1
Kovarik, M	1
Jalan, R	1
Olde Damink, SW	1
Ter Steege, JC	1
Redhead, DN	1
Lee, A	1
Hayes, PC	1
Deutz, NE	3
Castellani, M	1
Colombo, A	1
Giordano, R	1
Pusineri, E	1
Canzi, C	1
Longari, V	1
Piccaluga, E	1
Palatresi, S	1
Dellavedova, L	1
Soligo, D	1
Rebulla, P	1
Gerundini, P	1
Kasapkara, CS	1
Ezgu, FS	1
Okur, I	1
Tumer, L	1
Biberoglu, G	1
Hasanoglu, A	1
Schaefer, TV	1
Rejuniuk, VL	1
Malakhovsky, VN	1
Ivnitsky, JJ	1
Buis, CI	1
Wiesner, RH	1
Krom, RA	1
Kremers, WK	1
Wijdicks, EF	1
Mas, A	1
Rodés, J	1
Sunyer, L	1
Rodrigo, L	1
Planas, R	1
Vargas, V	1
Castells, L	1
Rodríguez-Martínez, D	1
Fernández-Rodríguez, C	1
Coll, I	1
Pardo, A	1
Luttinger, D	1
Wilson, L	1
García, MV	1
López-Mediavilla, C	1
Juanes de la Peña, MC	1
Medina, JM	1
DEBRAY, C	1
BESANCON, F	1
PAOLAGGI, JA	1
LODS, JC	1
Gessner, C	1
Hammerschmidt, S	1
Kuhn, H	1
Seyfarth, HJ	1
Sack, U	1
Engelmann, L	2
Schauer, J	1
Wirtz, H	1
Zhang, YX	1
Chen, SF	1
Wang, FJ	1
Liu, W	1
Loe, JN	1
Tong, ZH	1
Häberle, J	1
Koch, HG	1
Keiding, S	1
Sørensen, M	1
Bender, D	1
Munk, OL	1
Ott, P	2
Vilstrup, H	1
Clay, AS	1
Hainline, BE	1
Alleyne, GA	4
Lupianez, JA	1
McFarlane-Anderson, N	1
Hortelano, P	1
Benjamin, J	1
Barnswell, J	1
Scott, B	1
Dong, JM	1
Zhao, TR	1
Lashchevker, VM	1
Tannen, RL	8
Sastrasinh, S	2
Gougoux, A	4
Vinay, P	6
Lemieux, G	4
Goldstein, M	1
Stinebaugh, B	1
Halperin, M	1
Simon, E	1
Martin, D	1
Buerkert, J	1
Goyal, M	2
Cardoso, M	2
Duplain, M	2
Ono, J	1
Furukawa, T	2
Katsuki, T	1
O'Kane, GJ	1
Ward, K	1
Murray, B	1
Costello, GP	1
Jenkins, PJ	1
Williams, R	3
Sakoda, K	1
Akita, H	1
Fine, A	2
Roller, MH	1
Riedemann, GS	1
Romkema, GE	1
Swanson, RN	1
Narins, RG	3
Emmett, M	1
Rascoff, J	1
Jones, ER	1
Relman, AS	3
Iudakova, TM	1
Paukov, VS	1
Demurov, EA	1
Allignet, E	1
Pichette, C	1
Watford, M	1
Koen, H	1
Okuda, K	1
Musha, H	1
Tateno, Y	1
Fukuda, N	1
Matsumoto, T	1
Shisido, F	1
Rikitake, T	1
Iinuma, T	1
Kurisu, A	1
Arimizu, N	1
Bergqvist, PB	1
Vogels, BA	1
Bosman, DK	3
Maas, MA	3
Hjorth, S	1
Chamuleau, RA	4
Bengtsson, F	1
Jabbour, N	1
Karavias, D	1
Van Thiel, DH	1
Falk, MC	1
Knight, JF	1
Roy, LP	1
Wilcken, B	1
Schell, DN	1
O'Connell, AJ	1
Gillis, J	1
Tibi, T	1
Revault, MH	1
Ferrari, E	1
Freche, A	1
Roques, JC	1
Nissim, I	2
Sahai, A	5
Momo, K	1
Hoshina, K	1
Ishibashi, Y	1
Saito, T	1
Sandler, RS	2
Groeneweg, M	1
de Knegt, RJ	2
Hamberger, A	1
Ding, M	1
Wang, S	1
Schalm, SW	2
Haglid, KG	1
Kornhuber, J	1
Rusche, K	1
Riederer, P	1
Tan, J	1
Mair, TS	1
Jones, RD	1
Pascher, A	1
Poehlein, C	1
Stangl, M	1
Hoebel, G	1
Thiery, J	1
Mueller-Derlich, J	1
Hammer, C	1
Nandwani, N	1
Raphael, JH	1
Langton, JA	1
Nakajima, Y	1
Yoshioka, M	1
Mikami, O	1
Arai, S	1
Miyamoto, S	1
Manda, T	1
Yamanaka, N	1
Hirose, H	1
Motoi, Y	1
Miñana, MD	3
Llansola, M	1
Hermenegildo, C	1
Cucarella, C	1
Montoliu, C	1
Grisolía, S	3
Felipo, V	4
Sundari, PN	1
Wilfred, G	1
Ramakrishna, B	1
Litvinov, NN	1
Kazachkov, VI	1
Braun, MC	1
Welch, TR	1
da Fonseca, J	1
Brito, MJ	1
Freitas, J	1
Leal, C	1
Clemmesen, JO	1
Larsen, FS	2
Kondrup, J	1
Hansen, BA	2
Ellis, AJ	1
Hughes, RD	1
Nicholl, D	1
Langley, PG	1
Wendon, JA	1
O'Grady, JG	1
Kaminski, Y	1
Lopata, O	1
Muravyov, N	1
Benoist, S	1
Sarkis, R	1
Baudrimont, M	1
Delelo, R	1
Robert, A	1
Vaubourdolle, M	1
Balladur, P	1
Calmus, Y	1
Capeau, J	1
Nordlinger, B	2
Michalak, A	1
Rose, C	1
Butterworth, RF	1
Kobayashi, N	1
Noguchi, H	1
Fujiwara, T	1
Tanaka, N	1
Schmidt, LE	1
Svendsen, LB	1
Sørensen, VR	1
Kim, WH	1
Park, H	1
Yun, C	1
Cho, H	1
Kim, S	1
Paik, WK	1
Jeon, SH	1
Lee, JH	1
Hunt, JF	1
Erwin, E	1
Palmer, L	1
Vaughan, J	1
Malhotra, N	1
Platts-Mills, TA	1
Gaston, B	1
Hems, DA	1
Dobrzański, T	2
Pieschl, D	1
McFarlane Anderson, N	1
Bennett, FI	2
Maestracci, P	1
Grimaud, D	1
Bloch, P	2
Delorme, ML	1
Rapin, JR	1
Granger, A	1
Boschat, M	1
Opolon, P	3
Kindt, GW	1
Altenau, LL	1
Roobol, A	1
Mikhaĭluts, AP	1
Johnson, DR	1
Rieck, AF	1
De Vivo, DC	1
Chainuvati, T	1
Plengvanit, U	1
Viranuvatti, V	1
Benzi, G	1
Villa, RF	1
Arrigoni, E	1
Agnoli, A	1
Puletti, M	1
Jacobellis, GF	1
Greco, V	1
Pozzar, F	1
Lévy-Leblond, E	1
Gutton, P	1
Brigaudiot, C	1
Martine, C	1
Tournier, M	1
Truscelli, D	1
Panchenkov, RT	1
Penin, VA	1
Iarema, IV	1
Urtaev, BM	1
Kuznetsov, EV	1
Johansson, BB	1
Siesjö, BK	2
Walsh, WF	1
Harper, PV	1
Resnekov, L	1
Fill, H	1
Quintanilla, AP	1
Tonnesen, K	1
Martini, GA	1
Folbergrová, J	1
Norberg, K	1
Quistorff, B	1
Imler, M	1
Schlienger, JL	1
Kirn, A	1
Van Laethem, JL	1
Gay, F	1
Franck, N	1
Van Gossum, A	1
Schoolwerth, AC	1
Smith, BC	1
Drewnowska, K	1
Xu, G	1
Shayman, JA	1
Ujiie, K	1
Nonoguchi, H	1
Tomita, K	1
Marumo, F	1
Junco, E	2
Perez, R	2
Jofre, R	2
Alonso, S	2
Martinez, A	1
Tejedor, A	1
Madero, R	1
Valderrabano, F	2
Grau, E	1
De Graaf, AA	1
vd Hulst, RW	1
Van Eijk, HM	1
Bovée, WM	1
Jörning, GG	2
Smit, JJ	1
de Haan, JG	2
Goodman, SI	1
Greene, CL	1
Roterdamskaia, OM	1
Alimov, MM	1
Kasymov, AKh	1
Fukuizumi, H	1
Kudo, J	1
Shimamura, R	1
Fujimoto, K	1
Ishibashi, H	1
Niho, Y	1
Taniyama, T	1
Kumashiro, T	1
Clark, EC	1
Nath, KA	1
Hostetter, MK	1
Hostetter, TH	1
Halperin, ML	1
Ching, BC	1
Catzeflis, C	1
Bachmann, C	1
Hale, DE	1
Coates, PM	1
Wiesmann, U	1
Colombo, JP	1
Joris, F	1
Délèze, G	1
Surtees, R	1
Leonard, JV	2
Holness, DL	1
Purdham, JT	1
Nethercott, JR	1
Kiss, AL	1
Lemieux, C	1
Ibanez, RJ	1
Aranda, MR	1
Watson, AJ	1
Chambers, T	1
Karp, JE	1
Risch, VR	1
Walker, WG	1
Brusilow, SW	1
Kay, JD	1
Watanabe, A	2
Fujiwara, M	2
Shiota, T	2
Tsuji, T	1
Bogusky, RT	1
Dietrich, RL	1
Gilbert, GJ	1
Tizianello, A	1
Deferrari, G	1
Garibotto, G	1
Robaudo, C	1
Saffioti, S	1
Paoletti, E	1
Bruzzone, M	1
Rengel, M	1
Largillière, C	1
van Gool, J	1
Caballería Rovira, E	1
Arago López, JV	1
Masso Ubeda, RM	1
Vidal Clemente, JL	1
Sanchís Closa, A	1
Takei, N	1
Nagashima, H	1
Spezia, C	1
Fabiano, A	1
Bisarello, I	1
Soranzo, ML	1
Andreoni, G	1
Kimura, A	1
Yoshida, I	1
Ono, E	1
Matsuishi, T	1
Yoshino, M	1
Yamashita, F	1
Yamamoto, M	1
Hashimoto, T	1
Shinka, T	1
Kuhara, T	1
Ito, M	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Efficacy of Intravenous 'L-ornithine L-aspartate' in Reversal of Overt Acute Hepatic Encephalopathy in Patients With Liver Cirrhosis: a Prospective, Randomized, Double-blind, Placebo Controlled Trial[NCT01722578]	Phase 4	200 participants (Actual)	Interventional	2013-12-31	Completed
Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure: A Double- Blind, Randomized, Placebo- Controlled Study[NCT00470314]	Phase 2	150 participants (Actual)	Interventional	2005-01-31	Active, not recruiting
A Phase 2a Study to Evaluate the Safety and Tolerability of OCR-002 (Ornithine Phenylacetate) in the Treatment of Patients With Acute Liver Failure/Severe Acute Liver Injury[NCT01548690]	Phase 2	47 participants (Actual)	Interventional	2012-06-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

To evaluate the effect of OCR-002 on ammonia levels in patients with acute liver failure/severe acute liver injury (NCT01548690)
Timeframe: Baseline and 72 Hours

Measurement of OCR-002 Plasma Concentration

Intervention	Percent Change (Mean)
Maximum Dose Level 3.33 g/24h	41.2
Maximum Dose Level 6.65 g/24h	16.6
Maximum Dose Level 10 g/24h	41.8
Maximum Dose Level 20g/24h	38.4

To evaluate the steady state pharmacokinetic and pharmacodynamic profile of OCR-002 in patients with impaired and intact renal function using urinary phenylacetylglutamine (PAGN) as a surrogate marker (NCT01548690)
Timeframe: 24 Hours after last infusion

Neurological Function Measured by the Orientation Log (O-log)

Intervention	micrograms per millileter (Mean)
Maximum Dose Level 3.33 g/24h	65.6
Maximum Dose Level 6.65 g/24h	32.2
Maximum Dose Level 10 g/24h	33.4
Maximum Dose Level 20g/24h	104.9

The orientation log focuses on orientation to place, time, and circumstance. There are 10 items on the orientation log, which are scored 0-3. A spontaneous correct response is awarded 3 points. A spontaneous response that is lacking or incorrect, but a correct response is provided following a logical cue is awarded 2 points. A score of 1 is given if spontaneous and cued responses are lacking or incorrect, but a correct response is provided in a recognition format. A score of 0 is given if the spontaneous, cued, or recognition format does not generate a correct answer. Scores from the 10 items are summed and the final score ranges from 0 to 30. (NCT01548690)
Timeframe: 30 Days

Neurological Function Measured by the West Haven Criteria (WHC) for Hepatic Encephalopathy

Intervention	units on a scale (Mean)
Maximum Dose Level 3.33 g/24h	23.8
Maximum Dose Level 6.65 g/24h	24.0
Maximum Dose Level 10 g/24h	24.0
Maximum Dose Level 20g/24h	24.0

The West Haven Criteria (WHC) for Hepatic Encephalopathy measures the severity of encephalopathy and patient's level of consciousness. The scale ranges from 0 to 4; a minimum score of 0 represents a better outcome, and a maximum total score of 4 represents a worse outcome. A score of 0 corresponds to normal consciousness and behavior and normal neurological examination. A score of 1 corresponds to mild lack of awareness, shortened attention span, and impaired addition or subtraction; mild asterixis or tremor. A score of 2 corresponds to lethargy, disorientated or inappropriate behavior, obvious asterixis; slurred speech. A score of 3 corresponds to somnolent but arousable, gross disorientation or bizarre behavior, muscle rigidity and clonus; hyperreflexia. A score of 4 corresponds to coma and decerebrate posturing. (NCT01548690)
Timeframe: 120 hours from start of infusion

Number of Participants That do Not Tolerate the Administered Dose and Had Grade 3 or 4 Treatment Emergent Adverse Events as a Measure of Safety and Tolerability

Intervention	units on a scale (Mean)
Maximum Dose Level 3.33 g/24h	2.4
Maximum Dose Level 6.65 g/24h	3.2
Maximum Dose Level 10 g/24h	1.6
Maximum Dose Level 20g/24h	1.8

To evaluate the safety and tolerability of OCR-002 in patients with acute liver failure/severe acute liver injury (NCT01548690)
Timeframe: 30 Days

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Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration. Hepatology (Baltimore, Md.), 1999, Volume: 29, Issue:3 Topics: Acute Disease; Adult; Ammonia; Arteries; Encephalocele; Female; Hepatic Encephalopathy; Humans; Live	1999
Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration. Hepatology (Baltimore, Md.), 1999, Volume: 29, Issue:3 Topics: Acute Disease; Adult; Ammonia; Arteries; Encephalocele; Female; Hepatic Encephalopathy; Humans; Live	1999
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A reversible model of acute hepatic failure by temporary hepatic ischemia in the pig. The Journal of surgical research, 2000, Volume: 88, Issue:2 Topics: Acute Disease; Ammonia; Animals; Disease Models, Animal; Ischemia; Liver; Liver Failure; Male; Swine	2000
Loss of noradrenaline transporter sites in frontal cortex of rats with acute (ischemic) liver failure. Neurochemistry international, 2001, Volume: 38, Issue:1 Topics: Acute Disease; Ammonia; Animals; Brain Edema; Carrier Proteins; Fluoxetine; Frontal Lobe; Hepatic En	2001
Xenotransplantation of immortalized human hepatocytes for experimental acute liver failure in rats. Transplantation proceedings, 2000, Volume: 32, Issue:5 Topics: Acute Disease; Ammonia; Animals; Asialoglycoprotein Receptor; Cell Line, Transformed; Cell Transplan	2000
Cerebral blood flow velocity increases during a single treatment with the molecular adsorbents recirculating system in patients with acute on chronic liver failure. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2001, Volume: 7, Issue:8 Topics: Acute Disease; Adsorption; Adult; Ammonia; Arteries; Blood Flow Velocity; Cerebrovascular Circulatio	2001
Mixture of N-carbamoyl-L-glutamate plus L-arginine can protect rats with liver cirrhosis from acute ammonia intoxication. Journal of hepatology, 2001, Volume: 35, Issue:6 Topics: Acetates; Acute Disease; Ammonia; Animals; Arginine; Behavior, Animal; Carbamoyl-Phosphate Synthase	2001
Expression and activity of pH-regulatory glutaminase in the human airway epithelium. American journal of respiratory and critical care medicine, 2002, Jan-01, Volume: 165, Issue:1 Topics: Acute Disease; Adult; Ammonia; Analysis of Variance; Asthma; Biopsy; Blotting, Western; Breath Tests	2002
Plasma immunoreactive insulin and somatotropin in delirium tremens and alcoholic hallucinosis. Journal of studies on alcohol, 1976, Volume: 37, Issue:3 Topics: 17-Hydroxycorticosteroids; Acute Disease; Adult; Alcohol Withdrawal Delirium; Alcoholism; Ammonia; A	1976
Ammonia production by the small intestine of the rat. Biochimica et biophysica acta, 1976, Jun-23, Volume: 437, Issue:1 Topics: Acidosis; Acute Disease; Ammonia; Animals; Chronic Disease; Duodenum; gamma-Glutamyltransferase; Glu	1976
[Acute hepatocellular insufficiency or severe jaundice]. Annales de l'anesthesiologie francaise, 1976, Volume: 17, Issue:10 Topics: Acute Disease; Ammonia; Brain Diseases, Metabolic; Chemical and Drug Induced Liver Injury; Citric Ac	1976
Reversible modifications of neurotransmitters of the brain in experimental acute hepatic coma. Surgery, gynecology & obstetrics, 1978, Volume: 146, Issue:4 Topics: Acrylic Resins; Acrylonitrile; Acute Disease; Amino Acids; Ammonia; Animals; Brain; Cellulose; Coppe	1978
Primary dilation of the cerebral resistance vessels as a cause of increased intracranial pressure. Advances in neurology, 1978, Volume: 20 Topics: Acute Disease; Ammonia; Animals; Brain; Cerebrovascular Circulation; Disease Models, Animal; Electro	1978
Renal phosphate-dependent glutaminase activity and ammonia excretion during acute acidosis in the rat. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1979, Volume: 161, Issue:3 Topics: Acidosis; Acute Disease; Adaptation, Physiological; Ammonia; Animals; Bicarbonates; Chronic Disease;	1979
Reye syndrome: a metabolic response to an acute mitochondrial insult? Neurology, 1978, Volume: 28, Issue:2 Topics: Acute Disease; Adolescent; Adult; Ammonia; Brain Edema; Child; Coma; Diagnosis, Differential; Female	1978
Ornicetil on encephalopathy. Effect of ornicetil (ornithine alpha-ketoglutarate) on encephalopathy in patients with acute and chronic liver disease. Acta hepato-gastroenterologica, 1977, Volume: 24, Issue:6 Topics: Acute Disease; Adult; Ammonia; Chronic Disease; Drug Evaluation; Female; Hepatic Encephalopathy; Hum	1977
[Cerebral energy status and the acute hyperammoniaenia syndrome: interference of S-adenosyl-L-methionine and adenosine]. Minerva medica, 1978, Mar-03, Volume: 69, Issue:11 Topics: Acute Disease; Adenosine; Ammonia; Animals; Biotransformation; Brain; Dogs; Energy Metabolism; Glyco	1978
Acid gas-induced MI. American heart journal, 1978, Volume: 96, Issue:4 Topics: Acetates; Acute Disease; Ammonia; Gas Poisoning; Humans; Male; Middle Aged; Myocardial Infarction	1978
[Demonstration of portocaval encephalopathy in children]. La Psychiatrie de l'enfant, 1978, Volume: 21, Issue:1 Topics: Acute Disease; Adolescent; Ammonia; Child; Child, Preschool; Dietary Proteins; Electroencephalograph	1978
Effects of acute acid--base alterations on glutamine metabolism and renal ammoniagenesis in the dog. Clinical science and molecular medicine, 1978, Volume: 54, Issue:5 Topics: Acid-Base Imbalance; Acidosis; Acute Disease; Ammonia; Animals; Dogs; Female; Glutamine; Kidney; Mal	1978
[Lymph drainage in acute pancreatitis as a new method for elimination of endogenous intoxication]. Vestnik khirurgii imeni I. I. Grekova, 1977, Volume: 118, Issue:4 Topics: Acute Disease; Ammonia; Amylases; Cholecystitis; Drainage; Humans; Lymph; Pancreatitis; Thoracic Duc	1977
Brain energy metabolism in angiotensin-induced acute hypertension in rats. Acta physiologica Scandinavica, 1977, Volume: 100, Issue:2 Topics: Acute Disease; Ammonia; Angiotensin II; Animals; Blood-Brain Barrier; Brain; Energy Metabolism; Gluc	1977
Noninvasive evaluation of regional myocardial perfusion in 112 patients using a mobile scintillation camera and intravenous nitrogen-13 labeled ammonia. Circulation, 1976, Volume: 54, Issue:2 Topics: Acute Disease; Adult; Aged; Ammonia; Angina Pectoris; Animals; Coronary Circulation; Diagnosis, Diff	1976
Acute acid-base disorders. 2. Specific disturbances. Postgraduate medicine, 1976, Volume: 60, Issue:5 Topics: Acid-Base Imbalance; Acidosis; Acidosis, Respiratory; Acute Disease; Alkalies; Alkalosis; Alkalosis,	1976
Total devascularization of the Liver: an experimental model of acute liver failure. Scandinavian journal of gastroenterology. Supplement, 1976, Volume: 37 Topics: Acute Disease; Ammonia; Animals; Disease Models, Animal; Glucose; Lactates; Liver; Liver Diseases; P	1976
[Psychiatric-neurological disorders in chronic liver diseases]. Der Internist, 1975, Volume: 16, Issue:1 Topics: Acute Disease; Ammonia; Biotransformation; Brain Damage, Chronic; Brain Diseases; Chronic Disease; D	1975
Carbohydrate and amino acid metabolism in rat cerebral cortex in moderate and extreme hypercapnia. Journal of neurochemistry, 1975, Volume: 25, Issue:4 Topics: Acute Disease; Alanine; Amino Acids; Ammonia; Anesthesia, General; Animals; Asparagine; Aspartic Aci	1975
[Hyperammonemia and hypoglycemia in acute degenerative hepatitis induced in mice by frog virus 3]. Medecine & chirurgie digestives, 1975, Volume: 4 suppl 2 Topics: Acute Disease; Ammonia; Animals; Hepatitis A; Hepatitis Viruses; Hypoglycemia; Mice; Mice, Inbred St	1975
Hyperammoniemic coma in a patient with ureterosigmoidostomy and normal liver function. Digestive diseases and sciences, 1992, Volume: 37, Issue:11 Topics: Acute Disease; Adult; Ammonia; Colon, Sigmoid; Coma; Female; Humans; Liver; Postoperative Complicati	1992
Regulation of glutamine metabolism in dog kidney cortex: effect of pH and chronic acidosis. The American journal of physiology, 1992, Volume: 262, Issue:6 Pt 2 Topics: Acidosis; Acute Disease; Ammonia; Animals; Chronic Disease; Dogs; Glucose; Glutamine; Hydrogen; Hydr	1992
Signal transduction events whereby PGF2 alpha inhibits the ammoniagenic response to acute acidosis. The American journal of physiology, 1992, Volume: 262, Issue:6 Pt 2 Topics: Acidosis; Acute Disease; Alanine; Amiloride; Ammonia; Animals; Calcium Channel Blockers; Cell Line;	1992
Role of glutamate on ammoniagenesis from glutamine in acute metabolic acidosis. Contributions to nephrology, 1991, Volume: 92 Topics: Acidosis; Acute Disease; Ammonia; Animals; Glutamates; Glutamic Acid; Glutamine; Hydrogen-Ion Concen	1991
Acute and chronic metabolic acidosis in the pig: renal metabolism and ammoniagenesis. Contributions to nephrology, 1991, Volume: 92 Topics: Acidosis; Acute Disease; Adenosine Triphosphate; Ammonia; Animals; Chronic Disease; Glutamate Dehydr	1991
Ammonium ingestion prevents depletion of hepatic energy metabolites induced by acute ammonium intoxication. Archives of biochemistry and biophysics, 1991, Nov-01, Volume: 290, Issue:2 Topics: Acetates; Acetoacetates; Acute Disease; Ammonia; Animals; Diet; Dose-Response Relationship, Drug; En	1991
Changes in brain metabolism during hyperammonemia and acute liver failure: results of a comparative 1H-NMR spectroscopy and biochemical investigation. Hepatology (Baltimore, Md.), 1990, Volume: 12, Issue:2 Topics: Acute Disease; Ammonia; Animals; Brain; Brain Diseases; Electroencephalography; Glutamates; Glutamic	1990
The relationship between plasma free fatty acids and experimentally induced hepatic encephalopathy in the rat. Clinica chimica acta; international journal of clinical chemistry, 1991, Mar-15, Volume: 197, Issue:2 Topics: Acute Disease; Ammonia; Animals; Chronic Disease; Fatty Acids, Nonesterified; Hepatic Encephalopathy	1991
[Possibilities of hemosorption using a fibrous sorbent in acute hepatic failure (experimental study)]. Khirurgiia, 1990, Issue:12 Topics: Acrylic Resins; Acute Disease; Ammonia; Animals; Bilirubin; Blood Proteins; Disease Models, Animal;	1990
Prostaglandin F2 alpha inhibits the ammoniagenic response to acute acidosis in LLC-PK1 cells. Journal of the American Society of Nephrology : JASN, 1990, Volume: 1, Issue:6 Topics: Acidosis; Acute Disease; Ammonia; Cells, Cultured; Dinoprost; Dinoprostone; Kidney	1990
[Abrupt onset and rapid deterioration in the course of congenital ornithine transcarbamylase deficiency: a case report]. Fukuoka igaku zasshi = Hukuoka acta medica, 1990, Volume: 81, Issue:7 Topics: Acute Disease; Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Female; Humans; Ornithine	1990
Influence of acute hyponatremia on renal ammoniagenesis in dogs with chronic metabolic acidosis. The American journal of physiology, 1990, Volume: 258, Issue:2 Pt 2 Topics: Acidosis; Acute Disease; Ammonia; Animals; Chronic Disease; Deamino Arginine Vasopressin; Dogs; Glom	1990
Early diagnosis and treatment of neonatal medium-chain acyl-CoA dehydrogenase deficiency: report of two siblings. European journal of pediatrics, 1990, Volume: 149, Issue:8 Topics: Acid-Base Equilibrium; Acute Disease; Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Age Factors;	1990
Acute and chronic respiratory effects of occupational exposure to ammonia. American Industrial Hygiene Association journal, 1989, Volume: 50, Issue:12 Topics: Acute Disease; Adult; Ammonia; Chemical Industry; Chronic Disease; Humans; Occupational Diseases; Re	1989
Response of ammonia metabolism to acute acidosis: insights from cultured renal epithelium. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1989, Volume: 14, Issue:4 Topics: Acidosis; Acute Disease; Aminooxyacetic Acid; Ammonia; Animals; Antimetabolites; Cell Line; Epitheli	1989
Renal tubular biochemistry during acute and chronic metabolic alkalosis in the dog. Kidney international, 1985, Volume: 27, Issue:6 Topics: Acute Disease; Alkalosis; Ammonia; Animals; Chronic Disease; Citrates; Citric Acid; Cytosol; Dogs; G	1985
Transient idiopathic hyperammonaemia in adults. Lancet (London, England), 1985, Dec-07, Volume: 2, Issue:8467 Topics: Acute Disease; Adult; Amino Acids; Ammonia; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, A	1985
Acute encephalopathy and hyperammonaemia complicating treatment of acute lymphoblastic leukaemia with asparaginase. Lancet (London, England), 1986, Jan-18, Volume: 1, Issue:8473 Topics: Acute Disease; Ammonia; Asparaginase; Brain Edema; Child, Preschool; Humans; Leukemia, Lymphoid; Mal	1986
Amino acid neurotransmitters and their receptors in the brain synaptosomes of acute hepatic failure rats. Biochemical medicine and metabolic biology, 1988, Volume: 40, Issue:3 Topics: Acute Disease; Amino Acids; Ammonia; Animals; Brain; Glutamates; Hepatic Encephalopathy; Male; Neuro	1988
Effect of acute metabolic acidosis on ammonia metabolism in kidney. The American journal of physiology, 1989, Volume: 256, Issue:2 Pt 2 Topics: Acidosis; Acute Disease; Adenine Nucleotides; Amino Acids; Ammonia; Animals; Gas Chromatography-Mass	1989
Acute ammonia intoxication 37 years after ureterosigmoidostomy. Southern medical journal, 1988, Volume: 81, Issue:11 Topics: Acute Disease; Adult; Ammonia; Colon, Sigmoid; Hepatic Encephalopathy; Humans; Magnetic Resonance Im	1988
Renal ammoniagenesis in man with acute metabolic alkalosis. Contributions to nephrology, 1988, Volume: 63 Topics: Acute Disease; Adult; Alkalosis; Ammonia; Bicarbonates; Female; Humans; Kidney; Lactates; Lactic Aci	1988
Renal ammoniagenesis in acute hypokalemia in vivo in the dog. Contributions to nephrology, 1988, Volume: 63 Topics: Acute Disease; Adenosine Triphosphate; Ammonia; Animals; Dogs; Glomerular Filtration Rate; Hypokalem	1988
Protective effect of long term ammonium ingestion against acute ammonium intoxication. Biochemical and biophysical research communications, 1988, Jun-30, Volume: 153, Issue:3 Topics: Acute Disease; Ammonia; Animals; Drug Tolerance; Male; Rats; Rats, Inbred Strains; Urea	1988
[Partial ornithine carbamyl transferase deficiency]. Pediatrie, 1988, Volume: 43, Issue:4 Topics: Acute Disease; Ammonia; Coma; Female; Humans; Infant, Newborn; Liver Diseases; Ornithine Carbamoyltr	1988
Correlation between electroencephalographic and biochemical indices in acute hepatic encephalopathy in rats. Journal of hepatology, 1987, Volume: 4, Issue:3 Topics: Acute Disease; Alanine Transaminase; Amino Acids; Ammonia; Animals; Disease Models, Animal; Electroe	1987
[Treatment of hepatic encephalopathy with oral branched-chain amino acids: I. Acute hepatic encephalopathy]. Revista espanola de las enfermedades del aparato digestivo, 1987, Volume: 72, Issue:2 Topics: Acute Disease; Administration, Oral; Amino Acids, Branched-Chain; Ammonia; Female; Follow-Up Studies	1987
Ammonia detoxification by accelerated oxidation of branched chain amino acids in brains of acute hepatic failure rats. Biochemical medicine and metabolic biology, 1986, Volume: 35, Issue:3 Topics: Acute Disease; Amino Acids; Ammonia; Animals; Brain; Caproates; Carbon Tetrachloride Poisoning; Hepa	1986
[Blood ammonia evaluation in acute hepatitis A and B]. Minerva medica, 1986, Sep-29, Volume: 77, Issue:37 Topics: Acute Disease; Alanine Transaminase; Ammonia; Female; Follow-Up Studies; Hepatitis A; Hepatitis B; H	1986
Acute encephalopathy with hyperammonemia and dicarboxylic aciduria during calcium hopantenate therapy: a patient report. Brain & development, 1986, Volume: 8, Issue:6 Topics: Acute Disease; Ammonia; Brain Diseases; Child, Preschool; Female; gamma-Aminobutyric Acid; Humans; P	1986
[A comparative study of free amino acid levels in the serum and cerebral cortex in hepatic failure rats]. No to shinkei = Brain and nerve, 1986, Volume: 38, Issue:1 Topics: Acute Disease; Amino Acids; Ammonia; Animals; Blood-Brain Barrier; Carbon Tetrachloride; Cerebral Co	1986
[Evaluation of blood ammonia level in liver diseases]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1970, Dec-01, Volume: 25, Issue:23 Topics: Acute Disease; Alanine Transaminase; Alkaline Phosphatase; Ammonia; Aspartate Aminotransferases; Bil	1970
[Course studies on cerebral glutamine excretion in schizophrenics under treatment with tranquilizing agents]. Psychiatria clinica, 1973, Volume: 6, Issue:5 Topics: Acute Disease; Adenosine Monophosphate; Adenosine Triphosphate; Adult; Ammonia; Antipsychotic Agents	1973
[Hepatic involvement during acute respiratory decompensation of chronic broncho-pneumopathies]. Les Cahiers du College de medecine des hopitaux de Paris, 1969, Nov-15, Volume: 10, Issue:14 Topics: Acidosis, Respiratory; Acute Disease; Alanine Transaminase; Alkaline Phosphatase; Ammonia; Aspartate	1969
[Apropos of certain toxic effects of L-asparaginase in human therapy]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1971, May-08, Volume: 47, Issue:22 Topics: Acute Disease; Adult; Ammonia; Asparaginase; Asthenia; Blood Coagulation Disorders; Brain; Chemical	1971
[Case report on acute fatal inhalatory ammonia intoxication]. Lebensversicherungs Medizin, 1970, Volume: 22, Issue:3 Topics: Acute Disease; Adult; Ammonia; Humans; Male; Pulmonary Edema; Respiration	1970
Acute effects of acidosis on ammoniagenic pathways in the kidneys of the intact rat. The American journal of physiology, 1974, Volume: 227, Issue:4 Topics: Acidosis; Acute Disease; Ammonia; Animals; Glucose; Glucosephosphates; Glutamates; Glutamine; Glycer	1974
Discriminative and prognostic signs in acute hepatic coma, treated by exchange transfusions. Digestion, 1974, Volume: 11, Issue:1-2 Topics: Acute Disease; Adolescent; Adult; Alanine Transaminase; Ammonia; Aspartate Aminotransferases; Autops	1974
[Treatment of acute necrosis of the liver by hepatic transplantation. Comparative study of orthtopic and heterotopic grafts]. Journal de chirurgie, 1974, Volume: 108, Issue:4 Topics: Acute Disease; Ammonia; Animals; Bilirubin; Blood Coagulation Factors; Blood Platelets; Electroencep	1974
[Behavior of ammonia in cirrhosis and hepatic coma]. Revista espanola de las enfermedades del aparato digestivo, 1972, Dec-15, Volume: 38, Issue:8 Topics: Acute Disease; Ammonia; Chronic Disease; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Neurologic	1972
[Effect of haloperidol, chlordiazepoxide and chlormethiazole on Porter-Silber chromogens, glycogen and ammonia content in some organs of rats during acute ethanol intoxication]. Endokrynologia Polska, 1973, Volume: 24, Issue:2 Topics: Acute Disease; Alcoholic Intoxication; Ammonia; Animals; Brain; Chlordiazepoxide; Chlormethiazole; C	1973
Lactulose in the treatment of acute hepatic encephalopathy. The American journal of the medical sciences, 1973, Volume: 266, Issue:2 Topics: Acute Disease; Ammonia; Connecticut; Dietary Proteins; Evaluation Studies as Topic; Hepatic Encephal	1973
[Disorder of synthesis of ammonia and urea and excretion of amino acids in acute peritonitis]. Klinicheskaia meditsina, 1973, Volume: 51, Issue:11 Topics: Acute Disease; Amino Acids; Ammonia; Blood Urea Nitrogen; Female; Humans; Male; Peritonitis; Urea	1973
Acute hypercapnia and brain energy state in sustained hyperammonaemia. Journal of neurochemistry, 1974, Volume: 23, Issue:1 Topics: Acute Disease; Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Tripho	1974
Liver efficiency of patients treated with extracorporeal perfusion because of coma complicating viral hepatitis. Biochemical and coagulological studies. Polish medical journal, 1972, Volume: 11, Issue:4 Topics: Acute Disease; Alanine Transaminase; Ammonia; Aspartate Aminotransferases; Bilirubin; Blood Coagulat	1972
Non-essential 15 N retention in an alcoholic with acute kwashiorkor. Le Journal medical libanais. The Lebanese medical journal, 1971, Volume: 24, Issue:2 Topics: Acute Disease; Adult; Alcoholism; Ammonia; Citrates; Humans; Kwashiorkor; Male; Nitrogen; Nitrogen I	1971
[Remote after-effects of acute occupational lesions of the respiratory tract caused by irritating gases]. Gigiena truda i professional'nye zabolevaniia, 1971, Volume: 15, Issue:11 Topics: Acute Disease; Adult; Ammonia; Chlorine; Environmental Exposure; Female; Follow-Up Studies; Formalde	1971
Acute hepatic coma treated by cross circulation with irreversibly comatose donor. JAMA, 1970, Dec-28, Volume: 214, Issue:13 Topics: Acute Disease; Adult; Ammonia; Aspartate Aminotransferases; Bilirubin; Blood Donors; Brain Death; Br	1970
[The response of the senile body to acute metabolic acidosis]. Minerva medica, 1969, Sep-26, Volume: 60, Issue:77 Topics: Acidosis; Acids; Acute Disease; Aged; Ammonia; Ammonium Chloride; Bicarbonates; Carbon Dioxide; Huma	1969
Early diagnosis of fatal hepatitis. Digestion, 1970, Volume: 3, Issue:3 Topics: Acute Disease; Alanine Transaminase; Ammonia; Aspartate Aminotransferases; Autopsy; Bilirubin; Biops	1970
[Peritoneal fluid ammonia in the patients with acute appendicitis]. Geka chiryo. Surgical therapy, 1970, Volume: 22, Issue:1 Topics: Acute Disease; Ammonia; Appendicitis; Ascitic Fluid; Female; Humans; Pregnancy	1970
[Dietetic management in chronic liver diseases]. Polskie Archiwum Medycyny Wewnetrznej, 1970, Volume: 45, Issue:3 Topics: Acute Disease; Age Factors; Ammonia; Body Height; Body Weight; Diet Therapy; Dietary Carbohydrates;	1970
[Blood ammonia and acid-base equilibrium during acute atrophy of the liver]. Annales de medecine interne, 1970, Volume: 121, Issue:1 Topics: Acid-Base Equilibrium; Acute Disease; Adult; Alkalosis; Ammonia; Atrophy; Carbon Dioxide; Female; He	1970
Acute comatose hepatitis. Symptomatology and natural course. Minnesota medicine, 1971, Volume: 54, Issue:2 Topics: Acid-Base Equilibrium; Acute Disease; Ammonia; Ascites; Aspartate Aminotransferases; Bilirubin; Bloo	1971
[Hyperammonemia of acute respiratory insufficiency]. La Presse medicale, 1971, May-22, Volume: 79, Issue:25 Topics: Acute Disease; Ammonia; Humans; Respiratory Insufficiency	1971
[Case of acute hepatitis with symptom similar to Inose's hepatocerebral disease]. Saishin igaku. Modern medicine, 1968, Dec-10, Volume: 23, Issue:12 Topics: Acute Disease; Adult; Ammonia; Biopsy; Brain Diseases; Diagnosis, Differential; Electroencephalograp	1968
[On ammonia intoxication in acute peritonitis]. Vestnik khirurgii imeni I. I. Grekova, 1968, Volume: 101, Issue:7 Topics: Acute Disease; Ammonia; Child; Exudates and Transudates; Humans; Peritonitis	1968
[On the biochemical characteristics of the most acute form of radiation sickness]. Radiobiologiia, 1966, Volume: 6, Issue:3 Topics: Acute Disease; Ammonia; Animals; Brain Chemistry; Guinea Pigs; Radiation Injuries, Experimental	1966

ammonium hydroxide and Acute Disease