ammonium hydroxide has been researched along with Active Hyperemia in 20 studies
azane : Saturated acyclic nitrogen hydrides having the general formula NnHn+2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In 34 patients with HCM, PET was performed using (13)N-labeled ammonia during hyperemia induced by intravenous dipyridamole." | 3.74 | Spatial relationship between coronary microvascular dysfunction and delayed contrast enhancement in patients with hypertrophic cardiomyopathy. ( Betti, I; Camici, PG; Casolo, G; Cecchi, F; Olivotto, I; Pupi, A; Rega, L; Sciagrà, R; Sotgia, B, 2008) |
| "We observed that cerebral hyperemia follows an initial rise in brain water content, rather than in the cerebrospinal fluid concentration of glutamine." | 3.71 | Cerebral hyperemia and nitric oxide synthase in rats with ammonia-induced brain edema. ( Blei, AT; Gottstein, J; Larsen, FS, 2001) |
| " N-13 ammonia was administered intravenously and its distribution in the left ventricular myocardium recorded at rest and during dipyridamole-induced coronary hyperemia." | 3.66 | Noninvasive assessment of coronary stenoses by myocardial imaging during pharmacologic coronary vasodilation. VI. Detection of coronary artery disease in human beings with intravenous N-13 ammonia and positron computed tomography. ( Gomes, A; Gould, KL; Henze, E; Hoffman, EJ; Kuhl, DE; Phelps, ME; Schelbert, HR; Wisenberg, G, 1982) |
| " EM examination of the lungs of the truck driver showed no discernible toxic alterations in either the capillary endothelial cells or the Type I or II alveolar epithelial cells, and alveolar and capillary basement membranes were intact." | 1.27 | Ultrastructure of acute ammonia toxicity in the human lung. ( Burns, TR; Greenberg, SD; Jachimczyk, JA; Mace, ML, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.00) | 18.7374 |
| 1990's | 4 (20.00) | 18.2507 |
| 2000's | 9 (45.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, R | 1 |
| Li, X | 1 |
| Huangfu, S | 1 |
| Yao, Q | 1 |
| Wu, P | 1 |
| Wu, Z | 1 |
| Li, L | 1 |
| Wang, Y | 1 |
| Yang, M | 1 |
| Hacker, M | 1 |
| Zhou, H | 1 |
| Yan, R | 1 |
| Li, S | 1 |
| Hwang, D | 1 |
| Jeon, KH | 1 |
| Lee, JM | 1 |
| Park, J | 1 |
| Kim, CH | 1 |
| Tong, Y | 1 |
| Zhang, J | 1 |
| Bang, JI | 1 |
| Suh, M | 1 |
| Paeng, JC | 1 |
| Na, SH | 1 |
| Cheon, GJ | 1 |
| Cook, CM | 1 |
| Davies, JE | 1 |
| Koo, BK | 1 |
| Giubbini, R | 1 |
| Peli, A | 1 |
| Kruse, MJ | 1 |
| Kovell, L | 1 |
| Kasper, EK | 1 |
| Pomper, MG | 1 |
| Moller, DR | 1 |
| Solnes, L | 1 |
| Chen, ES | 1 |
| Schindler, TH | 1 |
| Packard, RRS | 1 |
| Maddahi, J | 1 |
| Benli, AC | 1 |
| Köksal, G | 1 |
| Ozkul, A | 1 |
| Sotgia, B | 1 |
| Sciagrà, R | 1 |
| Olivotto, I | 1 |
| Casolo, G | 1 |
| Rega, L | 1 |
| Betti, I | 1 |
| Pupi, A | 1 |
| Camici, PG | 1 |
| Cecchi, F | 1 |
| Warskulat, U | 1 |
| Görg, B | 1 |
| Bidmon, HJ | 1 |
| Müller, HW | 1 |
| Schliess, F | 1 |
| Häussinger, D | 1 |
| Kofoed, KF | 1 |
| Hove, JD | 1 |
| Freiberg, J | 1 |
| Høst, U | 1 |
| Holm, S | 1 |
| Kelbaek, H | 1 |
| Jalan, R | 2 |
| Brunken, RC | 1 |
| Perloff, JK | 1 |
| Czernin, J | 4 |
| Campisi, R | 1 |
| Purcell, S | 1 |
| Miner, PD | 1 |
| Child, JS | 1 |
| Schelbert, HR | 5 |
| Bernuau, J | 1 |
| Wisenberg, G | 1 |
| Phelps, ME | 3 |
| Gould, KL | 1 |
| Henze, E | 1 |
| Hoffman, EJ | 1 |
| Gomes, A | 1 |
| Kuhl, DE | 1 |
| Müller, P | 1 |
| Choi, Y | 2 |
| Aguilar, F | 1 |
| Nitzsche, EU | 2 |
| Buxton, DB | 1 |
| Sun, K | 1 |
| Huang, SC | 2 |
| Hoh, CK | 1 |
| Nagamachi, S | 1 |
| Kim, AS | 1 |
| Sun, KT | 1 |
| Böttcher, M | 1 |
| Singh, TP | 1 |
| Di Carli, MF | 1 |
| Sullivan, NM | 1 |
| Leonen, MF | 1 |
| Morrow, WR | 1 |
| Kotzerke, J | 1 |
| Glatting, G | 1 |
| van den Hoff, J | 1 |
| Höher, M | 1 |
| Neumaier, B | 1 |
| Wöhrle, J | 1 |
| Reske, SN | 1 |
| Larsen, FS | 1 |
| Gottstein, J | 1 |
| Blei, AT | 1 |
| Burns, TR | 1 |
| Mace, ML | 1 |
| Greenberg, SD | 1 |
| Jachimczyk, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 2a Study to Evaluate the Safety and Tolerability of OCR-002 (Ornithine Phenylacetate) in the Treatment of Patients With Acute Liver Failure/Severe Acute Liver Injury[NCT01548690] | Phase 2 | 47 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
To evaluate the effect of OCR-002 on ammonia levels in patients with acute liver failure/severe acute liver injury (NCT01548690)
Timeframe: Baseline and 72 Hours
| Intervention | Percent Change (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 41.2 |
| Maximum Dose Level 6.65 g/24h | 16.6 |
| Maximum Dose Level 10 g/24h | 41.8 |
| Maximum Dose Level 20g/24h | 38.4 |
To evaluate the steady state pharmacokinetic and pharmacodynamic profile of OCR-002 in patients with impaired and intact renal function using urinary phenylacetylglutamine (PAGN) as a surrogate marker (NCT01548690)
Timeframe: 24 Hours after last infusion
| Intervention | micrograms per millileter (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 65.6 |
| Maximum Dose Level 6.65 g/24h | 32.2 |
| Maximum Dose Level 10 g/24h | 33.4 |
| Maximum Dose Level 20g/24h | 104.9 |
The orientation log focuses on orientation to place, time, and circumstance. There are 10 items on the orientation log, which are scored 0-3. A spontaneous correct response is awarded 3 points. A spontaneous response that is lacking or incorrect, but a correct response is provided following a logical cue is awarded 2 points. A score of 1 is given if spontaneous and cued responses are lacking or incorrect, but a correct response is provided in a recognition format. A score of 0 is given if the spontaneous, cued, or recognition format does not generate a correct answer. Scores from the 10 items are summed and the final score ranges from 0 to 30. (NCT01548690)
Timeframe: 30 Days
| Intervention | units on a scale (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 23.8 |
| Maximum Dose Level 6.65 g/24h | 24.0 |
| Maximum Dose Level 10 g/24h | 24.0 |
| Maximum Dose Level 20g/24h | 24.0 |
The West Haven Criteria (WHC) for Hepatic Encephalopathy measures the severity of encephalopathy and patient's level of consciousness. The scale ranges from 0 to 4; a minimum score of 0 represents a better outcome, and a maximum total score of 4 represents a worse outcome. A score of 0 corresponds to normal consciousness and behavior and normal neurological examination. A score of 1 corresponds to mild lack of awareness, shortened attention span, and impaired addition or subtraction; mild asterixis or tremor. A score of 2 corresponds to lethargy, disorientated or inappropriate behavior, obvious asterixis; slurred speech. A score of 3 corresponds to somnolent but arousable, gross disorientation or bizarre behavior, muscle rigidity and clonus; hyperreflexia. A score of 4 corresponds to coma and decerebrate posturing. (NCT01548690)
Timeframe: 120 hours from start of infusion
| Intervention | units on a scale (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 2.4 |
| Maximum Dose Level 6.65 g/24h | 3.2 |
| Maximum Dose Level 10 g/24h | 1.6 |
| Maximum Dose Level 20g/24h | 1.8 |
To evaluate the safety and tolerability of OCR-002 in patients with acute liver failure/severe acute liver injury (NCT01548690)
Timeframe: 30 Days
| Intervention | Participants (Count of Participants) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 0 |
| Maximum Dose Level 6.65 g/24h | 0 |
| Maximum Dose Level 10 g/24h | 0 |
| Maximum Dose Level 20g/24h | 0 |
2 reviews available for ammonium hydroxide and Active Hyperemia
| Article | Year |
|---|---|
Pathophysiological basis of therapy of raised intracranial pressure in acute liver failure.
Topics: Ammonia; Animals; Brain Edema; Cerebrovascular Circulation; Encephalitis; Hepatic Encephalopathy; Hu | 2005 |
Induction of cerebral hyperemia by ammonia plus endotoxin: does hyperammonemia unlock the blood-brain barrier?
Topics: Ammonia; Animals; Blood-Brain Barrier; Brain; Endotoxins; Humans; Hyperemia; Lipopolysaccharides | 2007 |
3 trials available for ammonium hydroxide and Active Hyperemia
| Article | Year |
|---|---|
Variability of insulin-stimulated myocardial glucose uptake in healthy elderly subjects.
Topics: Ammonia; Blood Glucose; Dipyridamole; Fluorodeoxyglucose F18; Glucose; Glucose Clamp Technique; Hear | 2002 |
Noninvasive quantification of myocardial blood flow in humans. A direct comparison of the [13N]ammonia and the [15O]water techniques.
Topics: Adenosine; Adult; Ammonia; Animals; Coronary Circulation; Coronary Vessels; Dogs; Female; Half-Life; | 1996 |
Validation of myocardial blood flow estimation with nitrogen-13 ammonia PET by the argon inert gas technique in humans.
Topics: Adenosine; Aged; Algorithms; Ammonia; Argon; Coronary Circulation; Female; Heart; Hemodynamics; Huma | 2001 |
15 other studies available for ammonium hydroxide and Active Hyperemia
| Article | Year |
|---|---|
Combining body mass index with waist circumference to assess coronary microvascular function in patients with non-obstructive coronary artery disease.
Topics: Ammonia; Body Mass Index; Coronary Artery Disease; Coronary Circulation; Humans; Hyperemia; Myocardi | 2022 |
Diagnostic Performance of Resting and Hyperemic Invasive Physiological Indices to Define Myocardial Ischemia: Validation With
Topics: Aged; Ammonia; Area Under Curve; Arterial Pressure; Cardiac Catheterization; Coronary Angiography; C | 2017 |
Left ventricular function during hyperemia: A dive into the unknown.
Topics: Ammonia; Humans; Hyperemia; Nitrogen Radioisotopes; Ventricular Function; Ventricular Function, Left | 2018 |
Myocardial Blood Flow and Inflammatory Cardiac Sarcoidosis.
Topics: Ammonia; Blood Flow Velocity; Cardiomyopathies; Coronary Circulation; Female; Fluorodeoxyglucose F18 | 2017 |
Regadenoson-induced hyperemia for absolute myocardial blood flow quantitation by
Topics: Allografts; Ammonia; Coronary Circulation; Humans; Hyperemia; Nitrogen Radioisotopes; Purines; Pyraz | 2017 |
Sublethal ammonia exposure of Nile tilapia (Oreochromis niloticus L.): effects on gill, liver and kidney histology.
Topics: Ammonia; Animals; Chemical and Drug Induced Liver Injury; Cichlids; Gills; Glomerulonephritis; Hydro | 2008 |
Spatial relationship between coronary microvascular dysfunction and delayed contrast enhancement in patients with hypertrophic cardiomyopathy.
Topics: Adolescent; Adult; Aged; Ammonia; Cardiomyopathy, Hypertrophic; Contrast Media; Coronary Circulation | 2008 |
Ammonia-induced heme oxygenase-1 expression in cultured rat astrocytes and rat brain in vivo.
Topics: Ammonia; Animals; Animals, Newborn; Antioxidants; Astrocytes; Cells, Cultured; Cerebral Cortex; Gene | 2002 |
Myocardial perfusion reserve in adults with cyanotic congenital heart disease.
Topics: Adult; Ammonia; Blood Gas Analysis; Coronary Circulation; Female; Heart Defects, Congenital; Hemodyn | 2005 |
Noninvasive assessment of coronary stenoses by myocardial imaging during pharmacologic coronary vasodilation. VI. Detection of coronary artery disease in human beings with intravenous N-13 ammonia and positron computed tomography.
Topics: Adolescent; Adult; Aged; Ammonia; Coronary Disease; Coronary Vessels; Dipyridamole; Female; Humans; | 1982 |
Effect of exercise supplementation during adenosine infusion on hyperemic blood flow and flow reserve.
Topics: Adenosine; Adult; Ammonia; Aorta; Blood Pressure; Coronary Circulation; Coronary Vessels; Electrocar | 1994 |
Reproducibility of measurements of regional resting and hyperemic myocardial blood flow assessed with PET.
Topics: Adenosine; Adult; Ammonia; Coronary Circulation; Dipyridamole; Female; Hemodynamics; Humans; Hyperem | 1996 |
Myocardial flow reserve in long-term survivors of repair of anomalous left coronary artery from pulmonary artery.
Topics: Adenosine; Adolescent; Adult; Ammonia; Blood Pressure; Carbon Dioxide; Cardiac Output; Case-Control | 1998 |
Cerebral hyperemia and nitric oxide synthase in rats with ammonia-induced brain edema.
Topics: Ammonia; Anesthesia, General; Animals; Arteries; Body Water; Brain; Brain Edema; Cerebrovascular Cir | 2001 |
Ultrastructure of acute ammonia toxicity in the human lung.
Topics: Adult; Ammonia; Basement Membrane; Edema; Endothelium; Epithelium; Female; Humans; Hyperemia; Lung; | 1985 |