amlodipine has been researched along with Pregnancy in 27 studies
Amlodipine: A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
amlodipine : A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Given the results of this systematic review and meta-analysis, amlodipine can be effectively and safely used for hypertension during pregnancy." | 9.22 | Nifedipine or amlodipine? The choice for hypertension during pregnancy: a systematic review and meta-analysis. ( Du, P; Mei, Z; Qin, S; Shi, S; Yin, J, 2022) |
| "This pilot trial demonstrates that both furosemide and amlodipine might have the same effect during pregnancy." | 9.19 | Management of chronic hypertension during pregnancy with furosemide, amlodipine or aspirin: a pilot clinical trial. ( Dominguez, L; Solis, A; Vigil-De Gracia, P, 2014) |
| "Methyldopa and amlodipine are associated with the least side effects in pregnant women treated for chronic hypertension." | 7.96 | The comparison of side effects of methyldopa, amlodipine, and metoprolol in pregnant women with chronic hypertension. ( Ghafarzadeh, M; Namdari, P; Shakarami, A; Yari, F, 2020) |
| "Background Amlodipine is used for the treatment of hypertension, but reports on its use in early pregnancy are limited." | 7.91 | Safety of Amlodipine in Early Pregnancy. ( Arata, N; Ito, S; Kamiya, CA; Mikami, M; Mito, A; Miyasato-Isoda, M; Murashima, A; Suzuki, T; Wada, Y; Waguri, M; Watanabe, O; Yakuwa, N; Yoshimatsu, J, 2019) |
| "The aims of this study were to evaluate the plasma concentration of amlodipine and its passage into breast milk in lactating women with pregnancy-induced hypertension and to estimate the risk for breastfeeding infants." | 7.81 | Amlodipine passage into breast milk in lactating women with pregnancy-induced hypertension and its estimation of infant risk for breastfeeding. ( Deguchi, S; Itoh, H; Kanayama, N; Kawakami, J; Kubono, N; Naito, T; Sugihara, M, 2015) |
| "Given the results of this systematic review and meta-analysis, amlodipine can be effectively and safely used for hypertension during pregnancy." | 5.22 | Nifedipine or amlodipine? The choice for hypertension during pregnancy: a systematic review and meta-analysis. ( Du, P; Mei, Z; Qin, S; Shi, S; Yin, J, 2022) |
| "This pilot trial demonstrates that both furosemide and amlodipine might have the same effect during pregnancy." | 5.19 | Management of chronic hypertension during pregnancy with furosemide, amlodipine or aspirin: a pilot clinical trial. ( Dominguez, L; Solis, A; Vigil-De Gracia, P, 2014) |
| " The incidence of severe hypertension was significantly lower when nifedipine and methyldopa were administered, although preeclampsia risk was similar among antihypertensive agents." | 5.05 | Comparative efficacy and safety of oral antihypertensive agents in pregnant women with chronic hypertension: a network metaanalysis. ( Bellos, I; Daskalakis, G; Loutradis, D; Papapanagiotou, A; Pergialiotis, V, 2020) |
| "Methyldopa and amlodipine are associated with the least side effects in pregnant women treated for chronic hypertension." | 3.96 | The comparison of side effects of methyldopa, amlodipine, and metoprolol in pregnant women with chronic hypertension. ( Ghafarzadeh, M; Namdari, P; Shakarami, A; Yari, F, 2020) |
| "Background Amlodipine is used for the treatment of hypertension, but reports on its use in early pregnancy are limited." | 3.91 | Safety of Amlodipine in Early Pregnancy. ( Arata, N; Ito, S; Kamiya, CA; Mikami, M; Mito, A; Miyasato-Isoda, M; Murashima, A; Suzuki, T; Wada, Y; Waguri, M; Watanabe, O; Yakuwa, N; Yoshimatsu, J, 2019) |
| "Amlodipine is rarely used in the treatment of pregnant hypertensive women due to limited pharmacokinetic data during pregnancy and the postpartum period." | 3.88 | Pharmacokinetics of amlodipine besylate at delivery and during lactation. ( Kogutt, BK; McIntire, DD; Meek, C; Morgan, JL; Roberts, SW; Sheffield, JS; Stehel, EK, 2018) |
| "The aims of this study were to evaluate the plasma concentration of amlodipine and its passage into breast milk in lactating women with pregnancy-induced hypertension and to estimate the risk for breastfeeding infants." | 3.81 | Amlodipine passage into breast milk in lactating women with pregnancy-induced hypertension and its estimation of infant risk for breastfeeding. ( Deguchi, S; Itoh, H; Kanayama, N; Kawakami, J; Kubono, N; Naito, T; Sugihara, M, 2015) |
| " This study aims to investigate whether calcium channel blockers plus low dosage aspirin therapy can reduce the incidence of complications during pregnancy with chronic hypertension and improve the prognosis of neonates." | 3.81 | The effect of calcium channel blockers on prevention of preeclampsia in pregnant women with chronic hypertension. ( Jiang, N; Liu, L; Liu, Q; Yang, WW; Zeng, Y, 2015) |
| "Pre-eclampsia is still a very prevalent disease with critical hemodynamic changes." | 1.38 | Hemodynamic evaluation and anti-hypertensive schemes used in puerperal women following pre-eclampsia. ( Albarran, HA; Rodriguez, GC; Zeron, HM, 2012) |
| "Posterior reversible encephalopathy syndrome is a reversible syndrome characterized by headache, seizures, altered mentation, and loss of vision associated with white matter changes on imaging." | 1.35 | Late postpartum preeclampsia with posterior reversible encephalopathy syndrome. ( Kauntia, R; Pandit, VR; Prabhu, MM; Seshadri, S; Valsalan, R, 2009) |
| "Postpartum eclampsia is a serious and unexpected complication." | 1.34 | Late postpartum eclampsia at five weeks post-delivery. ( Agrawal, A; Lakshmi, R; Raina, A; Upreti, D, 2007) |
| "Malignant hypertension is a well-defined condition associated with high blood pressure and acute target-organ damage." | 1.33 | Malignant hypertension with intestinal ischemia secondary to juxtaglomerular cell tumor. ( Leitão, AA; Leite, CA; Libório, AB; Marques, Fde O; Praxedes, JN; Testagrossa, L, 2005) |
| "Subcutaneous fat necrosis of the newborn (SCFN) is a relatively uncommon condition of the skin which is said to be benign and painless." | 1.30 | Painful subcutaneous fat necrosis of the newborn associated with intra-partum use of a calcium channel blocker. ( Haque, KN; Holden, CA; Johnson, A; Rosbotham, JL, 1998) |
| "[3H]Lacidipine was avidly and promptly entrapped in A7r5 cells and was not removed by washout." | 1.29 | Ca2+ channel blocking activity of lacidipine and amlodipine in A7r5 vascular smooth muscle cells. ( Bachetti, T; Carboni, L; Ferri, S; Ratti, E; Spampinato, S; Van Amsterdam, FT, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (11.11) | 18.2507 |
| 2000's | 8 (29.63) | 29.6817 |
| 2010's | 10 (37.04) | 24.3611 |
| 2020's | 6 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Yin, J | 1 |
| Mei, Z | 1 |
| Shi, S | 1 |
| Du, P | 1 |
| Qin, S | 1 |
| Kikuchi, D | 1 |
| Obara, T | 2 |
| Miura, R | 1 |
| Suzuki, N | 1 |
| Hirakawa, H | 1 |
| Josaka, R | 1 |
| Ito, M | 1 |
| Tokunaga, M | 1 |
| Usui, K | 1 |
| Okada, K | 1 |
| Ishikawa, T | 1 |
| Nishigori, H | 1 |
| Akazawa, M | 1 |
| Miyakoda, K | 1 |
| Noda, A | 1 |
| Ishikuro, M | 1 |
| Metoki, H | 1 |
| Iwama, N | 1 |
| Saito, M | 1 |
| Sugawara, J | 1 |
| Kawame, H | 1 |
| Yaegashi, N | 1 |
| Kuriyama, S | 1 |
| Mano, N | 1 |
| Taguchi, R | 1 |
| Naito, T | 3 |
| Kubono, N | 3 |
| Ogawa, N | 1 |
| Itoh, H | 3 |
| Kawakami, J | 3 |
| Torky, HA | 1 |
| Shata, A | 1 |
| Ahmad, AM | 1 |
| Ragab, M | 1 |
| Abo-Louz, A | 1 |
| Hussein, A | 1 |
| Aly, R | 1 |
| Bellos, I | 1 |
| Pergialiotis, V | 1 |
| Papapanagiotou, A | 1 |
| Loutradis, D | 1 |
| Daskalakis, G | 1 |
| Ghafarzadeh, M | 1 |
| Shakarami, A | 1 |
| Yari, F | 1 |
| Namdari, P | 1 |
| Morgan, JL | 1 |
| Kogutt, BK | 1 |
| Meek, C | 1 |
| Stehel, EK | 1 |
| McIntire, DD | 1 |
| Sheffield, JS | 1 |
| Roberts, SW | 1 |
| Mito, A | 1 |
| Murashima, A | 1 |
| Wada, Y | 1 |
| Miyasato-Isoda, M | 1 |
| Kamiya, CA | 1 |
| Waguri, M | 1 |
| Yoshimatsu, J | 1 |
| Yakuwa, N | 1 |
| Watanabe, O | 1 |
| Suzuki, T | 1 |
| Arata, N | 1 |
| Mikami, M | 1 |
| Ito, S | 1 |
| Malha, L | 1 |
| August, P | 1 |
| Vigil-De Gracia, P | 1 |
| Dominguez, L | 1 |
| Solis, A | 1 |
| Deguchi, S | 2 |
| Sugihara, M | 2 |
| Kanayama, N | 2 |
| Jiang, N | 1 |
| Liu, Q | 1 |
| Liu, L | 1 |
| Yang, WW | 1 |
| Zeng, Y | 1 |
| Ishida, T | 1 |
| Wu, QA | 1 |
| Ye, YQ | 1 |
| Kauntia, R | 1 |
| Valsalan, R | 1 |
| Seshadri, S | 1 |
| Pandit, VR | 1 |
| Prabhu, MM | 1 |
| Rodriguez, GC | 1 |
| Albarran, HA | 1 |
| Zeron, HM | 1 |
| Linke, A | 1 |
| Li, W | 1 |
| Huang, H | 1 |
| Wang, Z | 2 |
| Hintze, TH | 2 |
| Davidovich, IM | 1 |
| Bloshchinskaia, IA | 1 |
| Petrichko, TA | 1 |
| Libório, AB | 1 |
| Marques, Fde O | 1 |
| Testagrossa, L | 1 |
| Leite, CA | 1 |
| Leitão, AA | 1 |
| Praxedes, JN | 1 |
| Ahn, HK | 1 |
| Nava-Ocampo, AA | 1 |
| Han, JY | 1 |
| Choi, JS | 1 |
| Chung, JH | 1 |
| Yang, JH | 1 |
| Koong, MK | 1 |
| Park, CT | 1 |
| Williams, JG | 1 |
| Rincon-Skinner, T | 1 |
| Sun, D | 1 |
| Zhang, S | 1 |
| Zhang, X | 1 |
| Lakshmi, R | 1 |
| Upreti, D | 1 |
| Agrawal, A | 1 |
| Raina, A | 1 |
| Spampinato, S | 1 |
| Bachetti, T | 1 |
| Carboni, L | 1 |
| Ratti, E | 1 |
| Van Amsterdam, FT | 1 |
| Ferri, S | 1 |
| Lechner, W | 1 |
| Bergant, A | 1 |
| Sölder, E | 1 |
| Kölle, D | 1 |
| Rosbotham, JL | 1 |
| Johnson, A | 1 |
| Haque, KN | 1 |
| Holden, CA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Amlodipine Versus Nifedipine ER for the Management of Postpartum Hypertension: A Randomized Controlled Noninferiority Trial[NCT04790279] | Phase 4 | 132 participants (Actual) | Interventional | 2021-04-09 | Completed | ||
| Cholesterol and CYP3A4/5 Metabolism Across Pregnancy and Postpartum[NCT05504889] | 36 participants (Actual) | Observational | 2022-06-17 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for amlodipine and Pregnancy
| Article | Year |
|---|---|
Nifedipine or amlodipine? The choice for hypertension during pregnancy: a systematic review and meta-analysis.
Topics: Amlodipine; Female; Humans; Hypertension; Infant, Newborn; Nifedipine; Obstetric Labor, Premature; P | 2022 |
Comparative efficacy and safety of oral antihypertensive agents in pregnant women with chronic hypertension: a network metaanalysis.
Topics: Abruptio Placentae; Amlodipine; Antihypertensive Agents; Atenolol; Cesarean Section; Chronic Disease | 2020 |
2 trials available for amlodipine and Pregnancy
| Article | Year |
|---|---|
Effect of amlodipine on blood flow of preovulatory follicle in women with clomiphene resistant polycystic ovaries: a randomized controlled trial.
Topics: Adult; Amlodipine; Calcium Channel Blockers; Clomiphene; Double-Blind Method; Female; Fertility Agen | 2020 |
Management of chronic hypertension during pregnancy with furosemide, amlodipine or aspirin: a pilot clinical trial.
Topics: Adult; Amlodipine; Antihypertensive Agents; Aspirin; Diuretics; Female; Furosemide; Humans; Hyperten | 2014 |
23 other studies available for amlodipine and Pregnancy
| Article | Year |
|---|---|
Antihypertensive drug prescription trends for pregnant women with hypertension in acute hospitals in Japan.
Topics: Amlodipine; Antihypertensive Agents; Calcium Channel Blockers; Drug Prescriptions; Female; Hospitals | 2022 |
Risk of major congenital malformations associated with first-trimester antihypertensives, including amlodipine and methyldopa: A large claims database study 2010-2019.
Topics: Amlodipine; Antihypertensive Agents; Female; Humans; Hypertension, Pregnancy-Induced; Male; Methyldo | 2023 |
Relationships between endogenous CYP3A markers and plasma amlodipine exposure and metabolism in early postpartum and non-peripartum women with hypertension.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Biomarker | 2019 |
The comparison of side effects of methyldopa, amlodipine, and metoprolol in pregnant women with chronic hypertension.
Topics: Adult; Amlodipine; Antihypertensive Agents; Blood Pressure; Female; Humans; Hypertension; Incidence; | 2020 |
Pharmacokinetics of amlodipine besylate at delivery and during lactation.
Topics: Adult; Amlodipine; Antihypertensive Agents; Chronic Disease; Delivery, Obstetric; Drug Monitoring; F | 2018 |
Safety of Amlodipine in Early Pregnancy.
Topics: Abnormalities, Drug-Induced; Aged; Amlodipine; Antihypertensive Agents; Chronic Disease; Female; Fol | 2019 |
Safety of Antihypertensive Medications in Pregnancy: Living With Uncertainty.
Topics: Amlodipine; Antihypertensive Agents; Female; Humans; Hypertension; Pregnancy; Uncertainty | 2019 |
Amlodipine passage into breast milk in lactating women with pregnancy-induced hypertension and its estimation of infant risk for breastfeeding.
Topics: Administration, Oral; Adult; Amlodipine; Antihypertensive Agents; Breast Feeding; Female; Humans; Hy | 2015 |
The effect of calcium channel blockers on prevention of preeclampsia in pregnant women with chronic hypertension.
Topics: Adult; Amlodipine; Aspirin; Birth Weight; Blood Pressure; Calcium Channel Blockers; China; Female; H | 2015 |
CYP3A activity based on plasma 4β-hydroxycholesterol during the early postpartum period has an effect on the plasma disposition of amlodipine.
Topics: Adult; Amlodipine; Antihypertensive Agents; Biomarkers; Biotransformation; Calcium Channel Blockers; | 2015 |
Neuromuscular blockade after therapy with magnesium sulfate and amlodipine.
Topics: Amlodipine; Drug Interactions; Female; Humans; Magnesium Sulfate; Neuromuscular Blockade; Neuromuscu | 2010 |
Late postpartum preeclampsia with posterior reversible encephalopathy syndrome.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Amlodipine; Antihypertensive Agent | 2009 |
Hemodynamic evaluation and anti-hypertensive schemes used in puerperal women following pre-eclampsia.
Topics: Adolescent; Adult; Amlodipine; Antihypertensive Agents; Benzimidazoles; Benzoates; Blood Pressure; C | 2012 |
Role of cardiac eNOS expression during pregnancy in the coupling of myocardial oxygen consumption to cardiac work.
Topics: Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Bradykinin; | 2002 |
[Gestational arterial hypertension. Mechanisms of formation. Treatment with normodipin].
Topics: Adolescent; Adult; Amlodipine; Antihypertensive Agents; Arm; Arteries; Blood Flow Velocity; Endothel | 2003 |
Malignant hypertension with intestinal ischemia secondary to juxtaglomerular cell tumor.
Topics: Abdomen, Acute; Acute Kidney Injury; Adenocarcinoma; Adult; Amlodipine; Antihypertensive Agents; Com | 2005 |
Exposure to amlodipine in the first trimester of pregnancy and during breastfeeding.
Topics: Adult; Amlodipine; Antihypertensive Agents; Blood Pressure; Breast Feeding; Calcium Channel Blockers | 2007 |
Role of nitric oxide in the coupling of myocardial oxygen consumption and coronary vascular dynamics during pregnancy in the dog.
Topics: Acetylcholine; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Coronary C | 2007 |
Late postpartum eclampsia at five weeks post-delivery.
Topics: Adult; Amlodipine; Antihypertensive Agents; Eclampsia; Female; Humans; Pregnancy; Puerperal Disorder | 2007 |
Ca2+ channel blocking activity of lacidipine and amlodipine in A7r5 vascular smooth muscle cells.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Cytosol; Dihydropyridines; Female; Fura-2; Muscle, Sm | 1993 |
[Effect of the calcium antagonist amlodipine on non-vascular smooth muscle exemplified by the uterus].
Topics: Amlodipine; Calcium Channel Blockers; Cesarean Section; Culture Techniques; Depression, Chemical; Fe | 1996 |
Painful subcutaneous fat necrosis of the newborn associated with intra-partum use of a calcium channel blocker.
Topics: Amlodipine; Calcium Channel Blockers; Fat Necrosis; Female; Humans; Hypertension; Infant, Newborn; M | 1998 |
Cutaneous drug reaction case reports: from the world literature.
Topics: Adolescent; Adverse Drug Reaction Reporting Systems; Aged; Amlodipine; Anti-Bacterial Agents; Anti-I | 2001 |