amlodipine has been researched along with Muscle Contraction in 16 studies
Amlodipine: A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
amlodipine : A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amlodipine orotate was prepared by reacting orotic acid and amlodipine to increase the dissolution rate at higher gastric pH conditions." | 5.33 | Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats. ( Ahn, BO; Choi, SM; Kim, JE; Kwon, JW, 2006) |
| " Metformin treatment improved the insulin sensitivity, and normalized the in vitro bladder hypercontractility and cystometric dysfunction in obese mice." | 3.78 | Role of PKC and CaV1.2 in detrusor overactivity in a model of obesity associated with insulin resistance in mice. ( Anhê, GF; Antunes, E; Calixto, MC; De Nucci, G; Grant, AD; Leiria, LO; Lintomen, L; Mónica, FZ; Sollon, C; Zanesco, A, 2012) |
| "Amlodipine is an intrinsically long-acting, vasoselective calcium antagonist structurally related to nifedipine, but with unique binding and pharmacologic properties that distinguish it from other agents of this class." | 2.39 | Unique pharmacologic properties of amlodipine. ( Burges, R; Moisey, D, 1994) |
| "Treatment with amlodipine was found to reduce myocardial oxygen demand, improve recovery of peak developed tension, have a favourable effect on Ca2+ fluxes, improve retention of tissue adenosine triphosphate and creatine phosphate, and reduce acidosis in the ischaemic/reperfused myocardium." | 2.38 | The pharmacological profile of amlodipine in relation to ischaemic heart disease. ( Burges, RA, 1991) |
| "Amlodipine orotate was prepared by reacting orotic acid and amlodipine to increase the dissolution rate at higher gastric pH conditions." | 1.33 | Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats. ( Ahn, BO; Choi, SM; Kim, JE; Kwon, JW, 2006) |
| " A possible use of the technique is shown using the example of the effect of varying the drug dosage on the contraction of the arteriole muscle." | 1.31 | A rapid procedure for initial drug evaluation. ( Macpherson, AK; Macpherson, PA; Neti, S, 2001) |
| "Pretreatment with methylene blue (10(-5) M) did not significantly influence the regional difference in the action of nicorandil." | 1.30 | Regional differences in the vasorelaxant effects of nicorandil and amlodipine on isolated porcine coronary arteries. ( Bagger, JP; Frøbert, O; Mikkelsen, EO; Tankó, LB, 1998) |
| "Amlodipine treatment (10 mg/kg/day orally) significantly reduced the increase in blood pressure (BP) in SHR, but did not change BP in WKY." | 1.29 | Selective interaction of the calcium antagonist amlodipine with calcium channels in arteries of spontaneously hypertensive rats. ( Godfraind, T; Morel, N, 1994) |
| "Amlodipine is a dihydropyridine that blocks L-type channels, thereby preventing entry of Ca2+ into the muscle." | 1.29 | Effect of chronic blood pressure reduction on soleus muscle contractile properties in spontaneously hypertensive rats. ( Atherley, R; Carlsen, RC; Gray, SD, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (56.25) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alker, D | 1 |
| Campbell, SF | 1 |
| Cross, PE | 1 |
| Burges, RA | 2 |
| Carter, AJ | 1 |
| Gardiner, DG | 1 |
| Garaliene, V | 2 |
| Barsys, V | 2 |
| Jakuska, P | 2 |
| Krauze, A | 1 |
| Duburs, G | 1 |
| Benetis, R | 1 |
| Leiria, LO | 1 |
| Sollon, C | 1 |
| Calixto, MC | 1 |
| Lintomen, L | 1 |
| Mónica, FZ | 1 |
| Anhê, GF | 1 |
| De Nucci, G | 1 |
| Zanesco, A | 1 |
| Grant, AD | 1 |
| Antunes, E | 1 |
| Beaton, LJ | 1 |
| Tarnopolsky, MA | 1 |
| Phillips, SM | 1 |
| Choi, SM | 1 |
| Kim, JE | 1 |
| Ahn, BO | 1 |
| Kwon, JW | 1 |
| Ozkul, Y | 1 |
| Morel, N | 1 |
| Godfraind, T | 1 |
| Moriyama, T | 1 |
| Karasawa, A | 1 |
| Woodmansey, PA | 1 |
| Zhang, F | 1 |
| Channer, KS | 1 |
| Morice, AH | 1 |
| Gray, SD | 1 |
| Carlsen, RC | 1 |
| Atherley, R | 1 |
| Burges, R | 1 |
| Moisey, D | 1 |
| Tankó, LB | 1 |
| Mikkelsen, EO | 1 |
| Frøbert, O | 1 |
| Bagger, JP | 1 |
| Macpherson, AK | 1 |
| Neti, S | 1 |
| Macpherson, PA | 1 |
| Yamanaka, K | 1 |
| Suzuki, M | 1 |
| Munehasu, S | 1 |
| Ishiko, J | 1 |
2 reviews available for amlodipine and Muscle Contraction
| Article | Year |
|---|---|
Unique pharmacologic properties of amlodipine.
Topics: Amlodipine; Animals; Aorta; Calcium Channel Blockers; Delayed-Action Preparations; Dogs; Hypertensio | 1994 |
The pharmacological profile of amlodipine in relation to ischaemic heart disease.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Cats; Coronary Disease; Dogs; Mice; Muscle Contractio | 1991 |
1 trial available for amlodipine and Muscle Contraction
| Article | Year |
|---|---|
Contraction-induced muscle damage in humans following calcium channel blocker administration.
Topics: Adult; Amlodipine; Calcium Channel Blockers; Cell Count; Creatine Kinase; Cross-Over Studies; Desmin | 2002 |
13 other studies available for amlodipine and Muscle Contraction
| Article | Year |
|---|---|
Long-acting dihydropyridine calcium antagonists. 4. Synthesis and structure-activity relationships for a series of basic and nonbasic derivatives of 2-[(2-aminoethoxy)methyl]-1,4-dihydropyridine calcium antagonists.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Chemical Phenomena; Chemistry; Dihydropyridines | 1990 |
Effects of calcium antagonists and agonists on isolated human v. saphena magna used for coronary artery bypass grafting and guinea pig's papillary muscle.
Topics: Action Potentials; Adult; Aged; Aged, 80 and over; Amlodipine; Animals; Benzimidazoles; Calcium Chan | 2011 |
Action of calcium antagonists and agonists on isolated human thoracic arteries used for coronary artery bypass grafting.
Topics: Adult; Aged; Aged, 80 and over; Amlodipine; Benzimidazoles; Calcium Channel Agonists; Calcium Channe | 2012 |
Role of PKC and CaV1.2 in detrusor overactivity in a model of obesity associated with insulin resistance in mice.
Topics: Adiposity; Amlodipine; Animals; Body Weight; Calcium Channel Blockers; Calcium Channels, L-Type; Cal | 2012 |
Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats.
Topics: Amlodipine; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Calcium; Cardiomegaly; Ce | 2006 |
Influence of calcium channel blocker drugs in neuromuscular transmission.
Topics: Adult; Amlodipine; Calcium Channel Blockers; Electromyography; Female; Fingers; Humans; Hypertension | 2007 |
Selective interaction of the calcium antagonist amlodipine with calcium channels in arteries of spontaneously hypertensive rats.
Topics: Administration, Oral; Amlodipine; Animals; Aorta; Binding Sites; Blood Pressure; Calcium Channels; C | 1994 |
Cardiovascular effects of benidipine and amlodipine in isolated tissues and anesthetized dogs.
Topics: Amlodipine; Analysis of Variance; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel | 1994 |
Effect of the calcium antagonist amlodipine on the two phases of hypoxic pulmonary vasoconstriction in rat large and small isolated pulmonary arteries.
Topics: Amlodipine; Analysis of Variance; Animals; Arteries; Hypoxia; In Vitro Techniques; Lung; Male; Muscl | 1995 |
Effect of chronic blood pressure reduction on soleus muscle contractile properties in spontaneously hypertensive rats.
Topics: Amlodipine; Animals; Blood Pressure; Hindlimb; Hydralazine; Male; Muscle Contraction; Rats; Rats, In | 1994 |
Regional differences in the vasorelaxant effects of nicorandil and amlodipine on isolated porcine coronary arteries.
Topics: Amlodipine; Animals; Calcium; Calcium Channel Blockers; Coronary Vessels; Enzyme Activation; Extrace | 1998 |
A rapid procedure for initial drug evaluation.
Topics: Amlodipine; Antihypertensive Agents; Arterioles; Calcium Channels; Computer Simulation; Dose-Respons | 2001 |
[Effect of amlodipine, a new calcium antagonist on isolated blood vessels].
Topics: Amlodipine; Animals; Aorta; Blood Vessels; Calcium Channel Blockers; Calcium Chloride; Coronary Vess | 1991 |