amlodipine has been researched along with Liver Failure in 2 studies
Amlodipine: A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
amlodipine : A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.
Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We have conducted a randomised, placebo-controlled trial to investigate the possible benefit of the calcium channel blocker amlodipine in terms of 4-week survival in hospitalised patients with severe acute alcoholic hepatitis." | 9.08 | Randomised controlled double-blind trial of the calcium channel antagonist amlodipine in the treatment of acute alcoholic hepatitis. ( Bird, GL; Danesh, BJ; Forrest, JA; McMahon, AD; Mills, PR; Prach, AT, 1998) |
| " We have conducted a randomised, placebo-controlled trial to investigate the possible benefit of the calcium channel blocker amlodipine in terms of 4-week survival in hospitalised patients with severe acute alcoholic hepatitis." | 5.08 | Randomised controlled double-blind trial of the calcium channel antagonist amlodipine in the treatment of acute alcoholic hepatitis. ( Bird, GL; Danesh, BJ; Forrest, JA; McMahon, AD; Mills, PR; Prach, AT, 1998) |
| " Cmax values were found to be similar in both groups although Tmax was shorter, and T1/2 was longer, in patients with hepatic insufficiency." | 1.29 | Pharmacokinetics and safety of single oral doses of amlodipine in patients with and without hepatic impairment: an open study. ( Darnis, F; Poupon, R, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Darnis, F | 1 |
| Poupon, R | 1 |
| Bird, GL | 1 |
| Prach, AT | 1 |
| McMahon, AD | 1 |
| Forrest, JA | 1 |
| Mills, PR | 1 |
| Danesh, BJ | 1 |
1 trial available for amlodipine and Liver Failure
| Article | Year |
|---|---|
Randomised controlled double-blind trial of the calcium channel antagonist amlodipine in the treatment of acute alcoholic hepatitis.
Topics: Acute Disease; Amlodipine; Biological Availability; Calcium Channel Blockers; Double-Blind Method; F | 1998 |
1 other study available for amlodipine and Liver Failure
| Article | Year |
|---|---|
Pharmacokinetics and safety of single oral doses of amlodipine in patients with and without hepatic impairment: an open study.
Topics: Adult; Amlodipine; Female; Half-Life; Hemodynamics; Humans; Liver Failure; Liver Function Tests; Mal | 1993 |