amlodipine has been researched along with Leukemia in 2 studies
Amlodipine: A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
amlodipine : A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objectives of the present study were to define whether amlodipine induces apoptosis and what mechanism is involved in the process in human resistant and non-resistant leukemia cells following co-administration of stealth liposomal topotecan with amlodipine, a novel antiresistant liposomes developed by our institution." | 7.73 | A novel stealth liposomal topotecan with amlodipine: apoptotic effect is associated with deletion of intracellular Ca2+ by amlodipine thus leading to an enhanced antitumor activity in leukemia. ( Hong, HY; Li, X; Liang, GW; Liu, Y; Long, C; Lu, WL; Ma, X; Ruan, GR; Wang, JC; Yuan, L; Zhang, Q; Zhang, X; Zhang, YT, 2006) |
| "The objectives of the present study were to define whether amlodipine induces apoptosis and what mechanism is involved in the process in human resistant and non-resistant leukemia cells following co-administration of stealth liposomal topotecan with amlodipine, a novel antiresistant liposomes developed by our institution." | 3.73 | A novel stealth liposomal topotecan with amlodipine: apoptotic effect is associated with deletion of intracellular Ca2+ by amlodipine thus leading to an enhanced antitumor activity in leukemia. ( Hong, HY; Li, X; Liang, GW; Liu, Y; Long, C; Lu, WL; Ma, X; Ruan, GR; Wang, JC; Yuan, L; Zhang, Q; Zhang, X; Zhang, YT, 2006) |
| "Topotecan alone was effective in inhibiting the growth of non-resistant leukaemia cells, K562 and HL-60 cells but not the growth of MDR HL-60 cells." | 1.33 | Effect of stealthy liposomal topotecan plus amlodipine on the multidrug-resistant leukaemia cells in vitro and xenograft in mice. ( Hong, HY; Li, X; Liang, GW; Liu, Y; Long, C; Lu, WL; Ruan, GR; Wang, JC; Zhang, Q; Zhang, X; Zhang, YT, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, X | 2 |
| Ruan, GR | 2 |
| Lu, WL | 2 |
| Hong, HY | 2 |
| Liang, GW | 2 |
| Zhang, YT | 2 |
| Liu, Y | 2 |
| Long, C | 2 |
| Ma, X | 1 |
| Yuan, L | 1 |
| Wang, JC | 2 |
| Zhang, X | 2 |
| Zhang, Q | 2 |
2 other studies available for amlodipine and Leukemia
| Article | Year |
|---|---|
A novel stealth liposomal topotecan with amlodipine: apoptotic effect is associated with deletion of intracellular Ca2+ by amlodipine thus leading to an enhanced antitumor activity in leukemia.
Topics: Amlodipine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Calcium; Caspases; Cell Survi | 2006 |
Effect of stealthy liposomal topotecan plus amlodipine on the multidrug-resistant leukaemia cells in vitro and xenograft in mice.
Topics: Amlodipine; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosi | 2006 |