amlodipine has been researched along with Left Ventricular Dysfunction in 24 studies
Amlodipine: A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
amlodipine : A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The Effect of Losartan and Amlodipine on Left Ventricular Diastolic Function in Patients With Mild-to-Moderate Hypertension (J-ELAN) study is a multicenter, prospective, randomized trial designed to assess the effects of losartan and amlodipine on LV diastolic function in hypertensive patients with LV diastolic dysfunction in the absence of systolic dysfunction." | 9.12 | Effect of losartan and amlodipine on left ventricular diastolic function in patients with mild-to-moderate hypertension (J-ELAN): rationale and design. ( , 2006) |
| "To estimate the influence of therapy with amlodipine (A) or lacidipine (L) on heart rate variability (HRV) time and frequency domain parameters in hypertensive patients with stable angina pectoris and isolated left ventricular diastolic dysfunction." | 9.11 | Effects of amlodipine and lacidipine on heart rate variability in hypertensive patients with stable angina pectoris and isolated left ventricular diastolic dysfunction. ( Brazdzionyte, J; Jurkevicius, R; Zabiela, V; Zaliūnas, R, 2005) |
| "A preliminary study suggested that the long-acting late-generation calcium-channel blocker amlodipine has favorable effects on exercise tolerance and is safe to use in heart failure, in contrast to earlier generation agents." | 9.09 | Effects of amlodipine on exercise tolerance, quality of life, and left ventricular function in patients with heart failure from left ventricular systolic dysfunction. ( Berk, M; DeAbate, CA; Gorwitt, J; Konstam, MA; Kukin, ML; LeJemtel, T; Levine, TB; Neuberg, G; Packer, M; Smith, WB; Udelson, JE; Vijay, NK, 2000) |
| "To assess the effect of short-term amlodipine therapy on baseline measures of sympathetic activity and baroreflex function in patients with chronic stable congestive heart failure (CHF)." | 9.08 | Effect of amlodipine on norepinephrine kinetics and baroreflex function in patients with congestive heart failure. ( Goldsmith, SR, 1997) |
| "S-amlodipine has been broadly used to treat hypertension, but its protective effects and underlying mechanism remain controversial." | 7.91 | S-amlodipine improves endothelial dysfunction via the RANK/RANKL/OPG system by regulating microRNA-155 in hypertension. ( He, C; Si, D; Yang, J; Yang, P; Zhao, Y, 2019) |
| "On the first day after myocardial infarction, the animals were randomly assigned to amlodipine treatment (n = 8) or untreated groups (MI; n = 9)." | 7.70 | Long acting calcium antagonist amlodipine prevents left ventricular remodeling after myocardial infarction in rats. ( Iwao, H; Kim, S; Omura, T; Shimada, T; Takemoto, Y; Takeuchi, K; Yoshikawa, J; Yoshiyama, M, 1998) |
| "This study examined the effects of chronic amlodipine treatment on left ventricular (LV) pump function, systemic hemodynamics, neurohormonal status, and regional blood flow distribution in an animal model of congestive heart failure (CHF) both at rest and with treadmill exercise." | 7.70 | Chronic amlodipine treatment during the development of heart failure. ( Clair, MJ; Dodd, MG; Hebbar, L; Hendrick, JW; Houck, WV; Kribbs, SB; Krombach, RS; Mukherjee, R; Spinale, FG; Zellner, JL, 1998) |
| "To show that rapid successful treatment of hypertension leads to improvement in cardiac morphology and function regardless of the pharmacological agents used." | 6.74 | Successful treatment of hypertension accounts for improvements in markers of diastolic function - a pilot study comparing hydrochlorothiazide-based and amlodipine-based treatment strategies. ( Day, AG; Ogunyankin, KO, 2009) |
| "To compare the effects of losartan and amlodipine on myocardial structure and function in hypertensive patients with Type 2 diabetes and left ventricular hypertrophy." | 5.16 | Losartan and amlodipine on myocardial structure and function: a prospective, randomized, clinical trial. ( Corradi, L; Derosa, G; Destro, M; Fogari, R; Lazzari, P; Mugellini, A; Preti, P; Zoppi, A, 2012) |
| " In this study, we administered amlodipine 5 mg or 10 mg to patients with hypertension in order to compare the efficacy and tolerability of low and high doses, and measured two surrogate markers of hypertensive target organ damage, i." | 5.13 | Effects of strict blood pressure control by a long-acting calcium channel blocker on brain natriuretic peptide and urinary albumin excretion rate in Japanese hypertensive patients. ( Hoshide, S; Ishikawa, J; Ishikawa, S; Kabutoya, T; Kario, K; Shimada, K; Uno, H, 2008) |
| "The Effect of Losartan and Amlodipine on Left Ventricular Diastolic Function in Patients With Mild-to-Moderate Hypertension (J-ELAN) study is a multicenter, prospective, randomized trial designed to assess the effects of losartan and amlodipine on LV diastolic function in hypertensive patients with LV diastolic dysfunction in the absence of systolic dysfunction." | 5.12 | Effect of losartan and amlodipine on left ventricular diastolic function in patients with mild-to-moderate hypertension (J-ELAN): rationale and design. ( , 2006) |
| "To estimate the influence of therapy with amlodipine (A) or lacidipine (L) on heart rate variability (HRV) time and frequency domain parameters in hypertensive patients with stable angina pectoris and isolated left ventricular diastolic dysfunction." | 5.11 | Effects of amlodipine and lacidipine on heart rate variability in hypertensive patients with stable angina pectoris and isolated left ventricular diastolic dysfunction. ( Brazdzionyte, J; Jurkevicius, R; Zabiela, V; Zaliūnas, R, 2005) |
| "A preliminary study suggested that the long-acting late-generation calcium-channel blocker amlodipine has favorable effects on exercise tolerance and is safe to use in heart failure, in contrast to earlier generation agents." | 5.09 | Effects of amlodipine on exercise tolerance, quality of life, and left ventricular function in patients with heart failure from left ventricular systolic dysfunction. ( Berk, M; DeAbate, CA; Gorwitt, J; Konstam, MA; Kukin, ML; LeJemtel, T; Levine, TB; Neuberg, G; Packer, M; Smith, WB; Udelson, JE; Vijay, NK, 2000) |
| "To assess the effect of short-term amlodipine therapy on baseline measures of sympathetic activity and baroreflex function in patients with chronic stable congestive heart failure (CHF)." | 5.08 | Effect of amlodipine on norepinephrine kinetics and baroreflex function in patients with congestive heart failure. ( Goldsmith, SR, 1997) |
| "S-amlodipine has been broadly used to treat hypertension, but its protective effects and underlying mechanism remain controversial." | 3.91 | S-amlodipine improves endothelial dysfunction via the RANK/RANKL/OPG system by regulating microRNA-155 in hypertension. ( He, C; Si, D; Yang, J; Yang, P; Zhao, Y, 2019) |
| "Aim of the METR study - to assess effect of antihypertensive therapy with fixed combination of angiotensin converting enzyme inhibitor lisinopril (10 mg) and calcium antagonist amlodipine (5 mg) on parameters of arterial wall stiffness and central hemodynamics in patients with stage I-II essential hypertension (EH) and functional class II-III ischemic heart disease." | 3.81 | [Stiffness of the Arterial Wall and Central Hemodynamics During Long-Term Combination Antihypertensive Therapy]. ( Glezer, MG; Prokofieva, EB, 2015) |
| "Although amlodipine, a long-acting L-type calcium channel blocker, reportedly prevents left ventricular remodeling and dysfunction after myocardial infarction, the mechanism responsible is not yet well understood." | 3.74 | Amlodipine inhibits granulation tissue cell apoptosis through reducing calcineurin activity to attenuate postinfarction cardiac remodeling. ( Aoyama, T; Esaki, M; Fujiwara, H; Fujiwara, T; Kanamori, H; Kawasaki, M; Maruyama, R; Minatoguchi, S; Miyata, S; Nakagawa, M; Ogino, A; Okada, H; Takemura, G; Ushikoshi, H, 2007) |
| "On the first day after myocardial infarction, the animals were randomly assigned to amlodipine treatment (n = 8) or untreated groups (MI; n = 9)." | 3.70 | Long acting calcium antagonist amlodipine prevents left ventricular remodeling after myocardial infarction in rats. ( Iwao, H; Kim, S; Omura, T; Shimada, T; Takemoto, Y; Takeuchi, K; Yoshikawa, J; Yoshiyama, M, 1998) |
| "This study examined the effects of chronic amlodipine treatment on left ventricular (LV) pump function, systemic hemodynamics, neurohormonal status, and regional blood flow distribution in an animal model of congestive heart failure (CHF) both at rest and with treadmill exercise." | 3.70 | Chronic amlodipine treatment during the development of heart failure. ( Clair, MJ; Dodd, MG; Hebbar, L; Hendrick, JW; Houck, WV; Kribbs, SB; Krombach, RS; Mukherjee, R; Spinale, FG; Zellner, JL, 1998) |
| "Hypertensive patients who had not achieved their target blood pressure with at least 4 weeks of ARB therapy were randomly assigned to receive either a fixed-dose combination of losartan and HCTZ (losartan/HCTZ; n=110) or a combination of amlodipine and a typical ARB dosage (CCB/ARB; n=121) and followed for 24 weeks." | 2.82 | Effect of Diuretic or Calcium-Channel Blocker Plus Angiotensin-Receptor Blocker on Diastolic Function in Hypertensive Patients. ( Ishii, K; Ito, H; Iwakura, K; Kihara, H; Toh, N; Watanabe, H; Yoshikawa, J, 2016) |
| "We studied 62 patients with untreated hypertension, randomly assigned to cilnidipine or amlodipine for 48 weeks." | 2.82 | Long-term effects of L- and N-type calcium channel blocker on uric acid levels and left atrial volume in hypertensive patients. ( Eguchi, A; Fujiwara, S; Hirotani, S; Komamura, K; Koshiba, M; Mano, T; Masaki, M; Masuyama, T; Sugahara, M; Tsujino, T, 2016) |
| "To show that rapid successful treatment of hypertension leads to improvement in cardiac morphology and function regardless of the pharmacological agents used." | 2.74 | Successful treatment of hypertension accounts for improvements in markers of diastolic function - a pilot study comparing hydrochlorothiazide-based and amlodipine-based treatment strategies. ( Day, AG; Ogunyankin, KO, 2009) |
| "Arterial hypertension is a cardinal precursor of congestive heart failure, and diastolic dysfunction is the most frequent mechanism for it." | 1.30 | [Arterial hypertension and systolic left ventricular dysfunction: therapeutic approach]. ( Anguita Sánchez, M, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (25.00) | 18.2507 |
| 2000's | 10 (41.67) | 29.6817 |
| 2010's | 8 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, J | 1 |
| Si, D | 1 |
| Zhao, Y | 1 |
| He, C | 1 |
| Yang, P | 1 |
| Prokofieva, EB | 1 |
| Glezer, MG | 1 |
| Toh, N | 1 |
| Ishii, K | 1 |
| Kihara, H | 1 |
| Iwakura, K | 1 |
| Watanabe, H | 1 |
| Yoshikawa, J | 2 |
| Ito, H | 1 |
| Masaki, M | 1 |
| Mano, T | 1 |
| Eguchi, A | 1 |
| Fujiwara, S | 1 |
| Sugahara, M | 1 |
| Hirotani, S | 2 |
| Tsujino, T | 2 |
| Komamura, K | 1 |
| Koshiba, M | 1 |
| Masuyama, T | 2 |
| Baysal, SS | 1 |
| Pirat, B | 1 |
| Okyay, K | 1 |
| Bal, UA | 1 |
| Uluçam, MZ | 1 |
| Öztuna, D | 1 |
| Müderrisoğlu, H | 1 |
| Uno, H | 1 |
| Ishikawa, J | 1 |
| Hoshide, S | 1 |
| Kabutoya, T | 1 |
| Ishikawa, S | 1 |
| Shimada, K | 1 |
| Kario, K | 1 |
| Lu, JC | 1 |
| Cui, W | 1 |
| Zhang, HL | 1 |
| Liu, F | 1 |
| Han, M | 1 |
| Liu, DM | 1 |
| Yin, HN | 1 |
| Zhang, K | 1 |
| Du, J | 1 |
| Ogunyankin, KO | 1 |
| Day, AG | 1 |
| Yoshida, C | 1 |
| Goda, A | 1 |
| Naito, Y | 1 |
| Nakaboh, A | 1 |
| Matsumoto, M | 1 |
| Otsuka, M | 1 |
| Ohyanagi, M | 1 |
| Lee-Kawabata, M | 1 |
| Iskenderov, BG | 1 |
| Sisina, ON | 1 |
| Burmistrova, LF | 1 |
| Fogari, R | 1 |
| Mugellini, A | 1 |
| Destro, M | 1 |
| Corradi, L | 1 |
| Lazzari, P | 1 |
| Zoppi, A | 1 |
| Preti, P | 1 |
| Derosa, G | 1 |
| Zaliūnas, R | 1 |
| Brazdzionyte, J | 1 |
| Zabiela, V | 1 |
| Jurkevicius, R | 1 |
| Iwashima, Y | 1 |
| Okada, M | 1 |
| Haneda, M | 1 |
| Yoshida, T | 1 |
| Kukla, P | 1 |
| Bryniarski, L | 1 |
| Korpak-Wysocka, R | 1 |
| Bartuś, S | 1 |
| Giszterowicz, D | 1 |
| Dobrowolski, W | 1 |
| Dudek, D | 1 |
| Erne, P | 1 |
| Schoenenberger, AW | 1 |
| Zuber, M | 1 |
| Burckhardt, D | 1 |
| Kiowski, W | 1 |
| Dubach, P | 1 |
| Resink, T | 1 |
| Pfisterer, M | 1 |
| Ogino, A | 1 |
| Takemura, G | 1 |
| Kanamori, H | 1 |
| Okada, H | 1 |
| Maruyama, R | 1 |
| Miyata, S | 1 |
| Esaki, M | 1 |
| Nakagawa, M | 1 |
| Aoyama, T | 1 |
| Ushikoshi, H | 1 |
| Kawasaki, M | 1 |
| Minatoguchi, S | 1 |
| Fujiwara, T | 1 |
| Fujiwara, H | 1 |
| Lewis, BS | 1 |
| Goldsmith, SR | 1 |
| White, CM | 1 |
| Shimada, T | 1 |
| Yoshiyama, M | 1 |
| Takeuchi, K | 1 |
| Omura, T | 1 |
| Takemoto, Y | 1 |
| Kim, S | 1 |
| Iwao, H | 1 |
| Spinale, FG | 1 |
| Mukherjee, R | 1 |
| Krombach, RS | 1 |
| Clair, MJ | 1 |
| Hendrick, JW | 1 |
| Houck, WV | 1 |
| Hebbar, L | 1 |
| Kribbs, SB | 1 |
| Zellner, JL | 1 |
| Dodd, MG | 1 |
| Anguita Sánchez, M | 1 |
| Udelson, JE | 1 |
| DeAbate, CA | 1 |
| Berk, M | 1 |
| Neuberg, G | 1 |
| Packer, M | 1 |
| Vijay, NK | 1 |
| Gorwitt, J | 1 |
| Smith, WB | 1 |
| Kukin, ML | 1 |
| LeJemtel, T | 1 |
| Levine, TB | 1 |
| Konstam, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Diuretic-based With Non-diuretic Based Hypertension Therapy Using Echocardiographic Measures[NCT00229242] | 38 participants (Actual) | Interventional | 2003-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for amlodipine and Left Ventricular Dysfunction
| Article | Year |
|---|---|
Calcium antagonists in patients with left ventricular dysfunction: back on the bridge?
Topics: Amlodipine; Calcium Channel Blockers; Felodipine; Humans; Myocardial Infarction; Ventricular Dysfunc | 1996 |
Calcium channel blockers in left ventricular dysfunction or congestive heart failure.
Topics: Amlodipine; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Felodipine; Heart Failure | 1997 |
13 trials available for amlodipine and Left Ventricular Dysfunction
| Article | Year |
|---|---|
Effect of Diuretic or Calcium-Channel Blocker Plus Angiotensin-Receptor Blocker on Diastolic Function in Hypertensive Patients.
Topics: Adult; Aged; Aged, 80 and over; Amlodipine; Angiotensin Receptor Antagonists; Blood Pressure; Calciu | 2016 |
Long-term effects of L- and N-type calcium channel blocker on uric acid levels and left atrial volume in hypertensive patients.
Topics: Amlodipine; Atrial Function, Left; Atrial Remodeling; Biomarkers; Blood Pressure; Calcium Channel Bl | 2016 |
Treatment-associated change in apelin concentration in patients with hypertension and its relationship with left ventricular diastolic function.
Topics: Amlodipine; Antihypertensive Agents; Apelin; Biomarkers; Case-Control Studies; Echocardiography; Fem | 2017 |
Effects of strict blood pressure control by a long-acting calcium channel blocker on brain natriuretic peptide and urinary albumin excretion rate in Japanese hypertensive patients.
Topics: Albuminuria; Amlodipine; Biomarkers; Blood Pressure; Blood Pressure Monitoring, Ambulatory; C-Reacti | 2008 |
Successful treatment of hypertension accounts for improvements in markers of diastolic function - a pilot study comparing hydrochlorothiazide-based and amlodipine-based treatment strategies.
Topics: Amlodipine; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Female; Humans; Hydr | 2009 |
Role of plasma aldosterone concentration in regression of left-ventricular mass following antihypertensive medication.
Topics: Adult; Aged; Aldosterone; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agen | 2011 |
Losartan and amlodipine on myocardial structure and function: a prospective, randomized, clinical trial.
Topics: Amlodipine; Antihypertensive Agents; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Angiopathie | 2012 |
Effects of amlodipine and lacidipine on heart rate variability in hypertensive patients with stable angina pectoris and isolated left ventricular diastolic dysfunction.
Topics: Adult; Aged; Amlodipine; Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Circadian Rhythm | 2005 |
Effect of losartan and amlodipine on left ventricular diastolic function in patients with mild-to-moderate hypertension (J-ELAN): rationale and design.
Topics: Adult; Amlodipine; Antihypertensive Agents; Blood Pressure; Diastole; Female; Humans; Hypertension; | 2006 |
Regression of cardiac hypertrophy in type 2 diabetes with hypertension by candesartan.
Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure | 2006 |
Effects of anti-ischaemic drug therapy in silent myocardial ischaemia type I: the Swiss Interventional Study on Silent Ischaemia type I (SWISSI I): a randomized, controlled pilot study.
Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Adult; Aged; Amlodipine; Bisoprolol; Death, Su | 2007 |
Effect of amlodipine on norepinephrine kinetics and baroreflex function in patients with congestive heart failure.
Topics: Aged; Amlodipine; Baroreflex; Blood Pressure; Calcium Channel Blockers; Cardiotonic Agents; Chronic | 1997 |
Effects of amlodipine on exercise tolerance, quality of life, and left ventricular function in patients with heart failure from left ventricular systolic dysfunction.
Topics: Aged; Amlodipine; Calcium Channel Blockers; Double-Blind Method; Exercise Test; Exercise Tolerance; | 2000 |
9 other studies available for amlodipine and Left Ventricular Dysfunction
| Article | Year |
|---|---|
S-amlodipine improves endothelial dysfunction via the RANK/RANKL/OPG system by regulating microRNA-155 in hypertension.
Topics: Amlodipine; Animals; Cell Line; Female; Human Umbilical Vein Endothelial Cells; Humans; Hypertension | 2019 |
[Stiffness of the Arterial Wall and Central Hemodynamics During Long-Term Combination Antihypertensive Therapy].
Topics: Aged; Amlodipine; Antihypertensive Agents; Aorta; Blood Pressure; Drug Combinations; Essential Hyper | 2015 |
Additive beneficial effects of amlodipine and atorvastatin in reversing advanced cardiac hypertrophy in elderly spontaneously hypertensive rats.
Topics: Aging; Amlodipine; Animals; Anticholesteremic Agents; Antihypertensive Agents; Atorvastatin; Cardiom | 2009 |
[Selection of rational combinations of indapamide with various of calcium antagonists in patients with arterial hypertension].
Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulat | 2011 |
[Transient left ventricular apical ballooning syndrome--a case report].
Topics: Aged; Amlodipine; Echocardiography, Doppler; Electrocardiography; Enoxaparin; Female; Humans; Simvas | 2007 |
Amlodipine inhibits granulation tissue cell apoptosis through reducing calcineurin activity to attenuate postinfarction cardiac remodeling.
Topics: Amlodipine; Animals; Apoptosis; bcl-Associated Death Protein; Calcineurin; Calcineurin Inhibitors; C | 2007 |
Long acting calcium antagonist amlodipine prevents left ventricular remodeling after myocardial infarction in rats.
Topics: Actins; Amlodipine; Animals; Atrial Natriuretic Factor; Blotting, Northern; Calcium Channel Blockers | 1998 |
Chronic amlodipine treatment during the development of heart failure.
Topics: Amlodipine; Animals; Coronary Circulation; Exercise Test; Heart Failure; Hemodynamics; Hormones; Myo | 1998 |
[Arterial hypertension and systolic left ventricular dysfunction: therapeutic approach].
Topics: Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Block | 1999 |