Page last updated: 2024-10-22

amlodipine and Gingival Overgrowth

amlodipine has been researched along with Gingival Overgrowth in 28 studies

Amlodipine: A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
amlodipine : A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.

Gingival Overgrowth: Excessive growth of the gingiva either by an increase in the size of the constituent cells (GINGIVAL HYPERTROPHY) or by an increase in their number (GINGIVAL HYPERPLASIA). (From Jablonski's Dictionary of Dentistry, 1992, p574)

Research Excerpts

ExcerptRelevanceReference
"Drug-induced gingival overgrowth is a condition caused by side effects of treatment with one of three types of drugs: phenytoin (used in epilepsy treatment), cyclosporine A (used in transplantology after allogenic organ transplants) and calcium channel blockers (used in the treatment of hypertension)."9.01Cyclosporine A and amlodipine induced gingival overgrowth in a kidney transplant recipient: case presentation with literature review. ( Arora, KS; Nanda, T; Sharma, P; Singh, B, 2019)
"Amlodipine is one of the commonly prescribed antihypertensive drugs, and gingival hyperplasia is one overlooked side effect in patients taking amlodipine."8.12Amlodipine Induced Gum Hypertrophy: A Rare Case Report. ( Bohra, GK; Chhabra, V; Kumar, D; Midha, N; Reddy, SC, 2022)
"Twenty-nine (29) individuals participated in the study, and they were assigned into 3 groups based on medical status and clinical periodontal examination; 9 patients with amlodipine-induced gingival overgrowth, 11 patients with inflammatory gingival overgrowth, and 9 healthy individuals as a control group."7.96Elevated Interleukin-17A expression in amlodipine-induced gingival overgrowth. ( Berker, E; Goyushov, S; Gultekin, SE; Ilarslan, Y; Ozer Yucel, O; Sume, SS; Tan, C; Tezcan, I, 2020)
"Amlodipine, calcium channel blocker (CCB), is used in the management of cardiovascular diseases which causes gingival overgrowth (GO)."7.96The gingival crevicular fluid levels of growth factors in patients with amlodipine-induced gingival overgrowth: A pilot study. ( Agrali, OB; Kose, KN; Kuru, B; Kuru, L; Noyan, U; Ozener, HO; Yildirim, HS; Yilmaz, S, 2020)
"Gingival overgrowth is a serious side effect that accompanies the use of amlodipine."7.91Molecular Aspects of Drug-Induced Gingival Overgrowth: An In Vitro Study on Amlodipine and Gingival Fibroblasts. ( Carinci, F; Cura, F; Della Vella, F; Di Stasio, D; Lauritano, D; Lucchese, A; Palmieri, A, 2019)
"To determine the prevalence of amlodipine-induced gingival overgrowth (GO) among elderly subjects attending an Indian teaching hospital and find any association with demographic factors, drug variables, oral hygiene status and gingival inflammation."7.78Prevalence of gingival overgrowth among elderly patients under amlodipine therapy at a large Indian teaching hospital. ( Bhat, GS; Bhat, KM; Karnik, R, 2012)
"Gingival overgrowth is a common side effect of cyclosporine A (CsA) therapy."7.72Risk factors of gingival overgrowth in kidney transplant recipients treated with cyclosporine A. ( Boratyńska, M; Klinger, M; Radwan-Oczko, M; Zietek, M, 2003)
"Gingival overgrowth is a common feature of periodontal diseases."5.43Amlodipine-Induced Gingival Overgrowth. ( Jayanthi, R; Rajan, PB, 2016)
"Drug-induced gingival overgrowth (DIGO) is a frequent adverse medication reaction that is generally caused by cyclosporine, phenytoin, and nifedipine, which belong to the category of immunosuppressants, anticonvulsants, and calcium channel blockers, respectively."5.22Bibliometric analysis of research trends and characteristics of drug-induced gingival overgrowth. ( Song, J; Wang, X; Wu, J; Zhang, R; Zhu, J, 2022)
"Drug-induced gingival overgrowth is a condition caused by side effects of treatment with one of three types of drugs: phenytoin (used in epilepsy treatment), cyclosporine A (used in transplantology after allogenic organ transplants) and calcium channel blockers (used in the treatment of hypertension)."5.01Cyclosporine A and amlodipine induced gingival overgrowth in a kidney transplant recipient: case presentation with literature review. ( Arora, KS; Nanda, T; Sharma, P; Singh, B, 2019)
"Amlodipine is one of the commonly prescribed antihypertensive drugs, and gingival hyperplasia is one overlooked side effect in patients taking amlodipine."4.12Amlodipine Induced Gum Hypertrophy: A Rare Case Report. ( Bohra, GK; Chhabra, V; Kumar, D; Midha, N; Reddy, SC, 2022)
" In this paper, we report the case of a late 80's female patient with hypertension who experienced amlodipine-induced gingival enlargement."4.12Gingival enlargement improvement following medication change from amlodipine to benidipine and periodontal therapy. ( Furui, M; Inagaki, K; Kamei, H; Matsubara, T, 2022)
"Amlodipine, calcium channel blocker (CCB), is used in the management of cardiovascular diseases which causes gingival overgrowth (GO)."3.96The gingival crevicular fluid levels of growth factors in patients with amlodipine-induced gingival overgrowth: A pilot study. ( Agrali, OB; Kose, KN; Kuru, B; Kuru, L; Noyan, U; Ozener, HO; Yildirim, HS; Yilmaz, S, 2020)
"The aim of the current study was to assess the association between 3 different calcium channel blockers (CCBs) (nifedipine, amlodipine and felodipine) and gingival overgrowth in patients with a diagnosis of severe refractory hypertension."3.88Influence of 3 calcium channel blockers on gingival overgrowth in a population of severe refractory hypertensive patients. ( de Souza, RC; Ferreira, DC; Fischer, RG; Gonçalves, LS; Vidal, F, 2018)
"Fragments of gingival tissue collected from patients clinically diagnosed with gingival overgrowth after chronic administration of nifedipine and amlodipine were processed for paraffin embedding."3.80Role of transforming growth factor β-connective tissue growth factor pathway in dihydropyridine calcium channel blockers-induced gingival overgrowth. ( Andrei, AM; Banită, IM; Berbecaru-Iovan, A; Munteanu, C; Pisoschi, CG; Popescu, F; Stănciulescu, CE, 2014)
"Gingival overgrowth is a common side effect of cyclosporine A (CsA) therapy."3.72Risk factors of gingival overgrowth in kidney transplant recipients treated with cyclosporine A. ( Boratyńska, M; Klinger, M; Radwan-Oczko, M; Zietek, M, 2003)
"The prevalence of gingival overgrowth in renal transplant recipients maintained on cyclosporin A and nifedipine is lower than those treated with cyclosporin A and amlodipine."3.70The calcium channel blocker used with cyclosporin has an effect on gingival overgrowth. ( Boomer, S; Campbell, BA; Hull, PS; Irwin, CR; Jamal, S; James, JA; Johnson, RW; Linden, GJ; Marley, JJ; Maxwell, AP; Short, CD; Spratt, H, 2000)
"Nifedipine was resumed during periodontal treatment when the patient's hypertension worsened."1.62Treatment of calcium channel blocker-induced gingival overgrowth without modifying medication. ( Miyashita, Y; Morikawa, S; Nakagawa, T; Nasu, M, 2021)
"Amlodipine was suspected and suspended in agreement with his physician."1.56Amlodipine-induced gingival enlargement: A case report. ( Giran, G; Keribin, P; Lesclous, P; Quenel, L; Tessier, MH, 2020)
"Gingival overgrowth is a common feature of periodontal diseases."1.43Amlodipine-Induced Gingival Overgrowth. ( Jayanthi, R; Rajan, PB, 2016)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (17.86)29.6817
2010's13 (46.43)24.3611
2020's10 (35.71)2.80

Authors

AuthorsStudies
Reddy, SC1
Midha, N1
Chhabra, V1
Kumar, D1
Bohra, GK1
Tuma, M1
Silva Andrade, N1
Correia Aires, R1
Cristelli, MP1
Medina Pestana, JO1
Gallottini, M2
Kamei, H1
Furui, M1
Matsubara, T1
Inagaki, K1
Zhang, R1
Wu, J1
Zhu, J1
Wang, X1
Song, J1
Sume, SS1
Berker, E1
Ilarslan, Y1
Ozer Yucel, O1
Tan, C1
Goyushov, S1
Gultekin, SE1
Tezcan, I1
Kose, KN1
Yilmaz, S1
Noyan, U1
Kuru, B1
Yildirim, HS1
Agrali, OB1
Ozener, HO1
Kuru, L1
Glick, A1
Sista, V1
Johnson, C1
Morikawa, S1
Nasu, M1
Miyashita, Y1
Nakagawa, T1
Misra, SR1
Koduru Lakshmi, S1
Mohanty, N1
Kendall, P1
Pugashetti, JV1
Aronowitz, P1
Chaubal, T1
Bapat, R1
Campos, L1
Pallos, D1
Simões, A1
Martins, F1
Vidal, F1
de Souza, RC1
Ferreira, DC1
Fischer, RG1
Gonçalves, LS1
Lauritano, D1
Lucchese, A1
Di Stasio, D1
Della Vella, F1
Cura, F1
Palmieri, A1
Carinci, F1
Quenel, L1
Keribin, P1
Giran, G1
Tessier, MH1
Lesclous, P1
Nanda, T1
Singh, B1
Sharma, P1
Arora, KS1
Pisoschi, CG1
Stănciulescu, CE1
Andrei, AM1
Berbecaru-Iovan, A1
Munteanu, C1
Popescu, F1
Banită, IM1
Jayanthi, R1
Rajan, PB1
Dubrey, SW1
Grocott-Mason, R1
Shimizu, T1
Kubota, T1
Nakasone, N1
Abe, D1
Morozumi, T1
Yoshie, H1
Agnihotri, R1
Bhat, GS2
Bhat, KM2
Karnik, R1
Banthia, R1
Jain, P1
Banthia, P1
Belludi, S1
Jain, AK1
Sharma, S1
Sharma, A1
Obiechina, NS1
Fine, JB1
Radwan-Oczko, M1
Boratyńska, M1
Klinger, M1
Zietek, M1
Yoon, AJ1
Pulse, C1
Cohen, LD1
Lew, TA1
Zegarelli, DJ1
James, JA1
Marley, JJ1
Jamal, S1
Campbell, BA1
Short, CD1
Johnson, RW1
Hull, PS1
Spratt, H1
Irwin, CR1
Boomer, S1
Maxwell, AP1
Linden, GJ1

Reviews

2 reviews available for amlodipine and Gingival Overgrowth

ArticleYear
Bibliometric analysis of research trends and characteristics of drug-induced gingival overgrowth.
    Frontiers in public health, 2022, Volume: 10

    Topics: Amlodipine; Anticonvulsants; Bibliometrics; Calcium Channel Blockers; Cyclosporine; Gingival Overgro

2022
Cyclosporine A and amlodipine induced gingival overgrowth in a kidney transplant recipient: case presentation with literature review.
    BMJ case reports, 2019, May-28, Volume: 12, Issue:5

    Topics: Adult; Amlodipine; Cyclosporine; Drug Therapy, Combination; Gingival Overgrowth; Humans; Immunosuppr

2019

Other Studies

26 other studies available for amlodipine and Gingival Overgrowth

ArticleYear
Amlodipine Induced Gum Hypertrophy: A Rare Case Report.
    Current drug safety, 2022, Volume: 17, Issue:3

    Topics: Aged; Amlodipine; Calcium Channel Blockers; Gingival Hyperplasia; Gingival Overgrowth; Humans; Hyper

2022
Oral findings in kidney transplant children and adolescents.
    International journal of paediatric dentistry, 2022, Volume: 32, Issue:6

    Topics: Adolescent; Amlodipine; Anticonvulsants; Child; Dental Caries; Everolimus; Female; Gingival Overgrow

2022
Gingival enlargement improvement following medication change from amlodipine to benidipine and periodontal therapy.
    BMJ case reports, 2022, May-19, Volume: 15, Issue:5

    Topics: Amlodipine; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Female; Gingival Hy

2022
Elevated Interleukin-17A expression in amlodipine-induced gingival overgrowth.
    Journal of periodontal research, 2020, Volume: 55, Issue:5

    Topics: Amlodipine; Antihypertensive Agents; Dental Plaque Index; Gingival Crevicular Fluid; Gingival Overgr

2020
The gingival crevicular fluid levels of growth factors in patients with amlodipine-induced gingival overgrowth: A pilot study.
    Nigerian journal of clinical practice, 2020, Volume: 23, Issue:4

    Topics: Amlodipine; Cardiovascular Agents; Cardiovascular Diseases; Gingival Crevicular Fluid; Gingival Over

2020
Oral Manifestations of Commonly Prescribed Drugs.
    American family physician, 2020, 11-15, Volume: 102, Issue:10

    Topics: Albuterol; Amlodipine; Anticonvulsants; Antihypertensive Agents; Atorvastatin; Bisphosphonate-Associ

2020
Treatment of calcium channel blocker-induced gingival overgrowth without modifying medication.
    BMJ case reports, 2021, Jan-11, Volume: 14, Issue:1

    Topics: Aged; Amlodipine; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Gingival Overgrowth; Humans;

2021
Amlodipine induced gingival enlargement.
    BMJ case reports, 2021, Aug-03, Volume: 14, Issue:8

    Topics: Amlodipine; Calcium Channel Blockers; Gingival Hyperplasia; Gingival Overgrowth; Humans

2021
Drug-induced gingival overgrowth after renal transplantation.
    Journal of general internal medicine, 2017, Volume: 32, Issue:12

    Topics: Amlodipine; Calcium Channel Blockers; Drug Interactions; Gingival Overgrowth; Humans; Immunosuppress

2017
Mulberry-Shaped Gingival Overgrowth Induced by Amlodipine and Cyclosporine.
    The American journal of the medical sciences, 2017, Volume: 354, Issue:6

    Topics: Adult; Amlodipine; Antihypertensive Agents; Cyclosporine; Drug Therapy, Combination; Female; Gingiva

2017
High-power diode laser on management of drug-induced gingival overgrowth: Report of two cases and long-term follow-up.
    Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology, 2018, Volume: 20, Issue:4

    Topics: Adolescent; Amlodipine; Calcium Channel Blockers; Child; Female; Follow-Up Studies; Gingival Overgro

2018
Influence of 3 calcium channel blockers on gingival overgrowth in a population of severe refractory hypertensive patients.
    Journal of periodontal research, 2018, Volume: 53, Issue:5

    Topics: Adult; Aged; Amlodipine; Brazil; Calcium Channel Blockers; Felodipine; Female; Gingival Overgrowth;

2018
Molecular Aspects of Drug-Induced Gingival Overgrowth: An In Vitro Study on Amlodipine and Gingival Fibroblasts.
    International journal of molecular sciences, 2019, Apr-25, Volume: 20, Issue:8

    Topics: Amlodipine; Cell Line; Fibroblasts; Gene Expression Profiling; Gene Expression Regulation; Gingiva;

2019
Amlodipine-induced gingival enlargement: A case report.
    Journal of stomatology, oral and maxillofacial surgery, 2020, Volume: 121, Issue:3

    Topics: Amlodipine; Calcium Channel Blockers; Gingival Overgrowth; Humans; Male; Middle Aged

2020
Role of transforming growth factor β-connective tissue growth factor pathway in dihydropyridine calcium channel blockers-induced gingival overgrowth.
    Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2014, Volume: 55, Issue:2

    Topics: Adult; Amlodipine; Calcium Channel Blockers; Calcium Channels, L-Type; Connective Tissue Growth Fact

2014
Amlodipine-Induced Gingival Overgrowth.
    The Journal of the Association of Physicians of India, 2016, Volume: 64, Issue:3

    Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Calcium Channel Blockers; Female; Gingival Overgro

2016
Gingival overgrowth secondary to amlodipine.
    British journal of hospital medicine (London, England : 2005), 2009, Volume: 70, Issue:9

    Topics: Aged; Amlodipine; Calcium Channel Blockers; Female; Gingival Overgrowth; Humans; Male

2009
Microarray and quantitative RT-PCR analyses in calcium-channel blockers induced gingival overgrowth tissues of periodontitis patients.
    Archives of oral biology, 2011, Volume: 56, Issue:3

    Topics: Aged; Amlodipine; Calcium Channel Blockers; Case-Control Studies; Cathepsin L; Cluster Analysis; Fem

2011
Amlodipine-induced gingival overgrowth: considerations in a geriatric patient.
    Geriatrics & gerontology international, 2011, Volume: 11, Issue:3

    Topics: Aged; Amlodipine; Calcium Channel Blockers; Female; Gingival Overgrowth; Humans

2011
Prevalence of gingival overgrowth among elderly patients under amlodipine therapy at a large Indian teaching hospital.
    Gerodontology, 2012, Volume: 29, Issue:3

    Topics: Aged; Aged, 80 and over; Amlodipine; Calcium Channel Blockers; Cross-Sectional Studies; Dental Plaqu

2012
Amlodipine- induced gingival overgrowth: a case report.
    The Journal of the Michigan Dental Association, 2012, Volume: 94, Issue:9

    Topics: Adult; Amlodipine; Antihypertensive Agents; Calcium Channel Blockers; Female; Gingival Overgrowth; H

2012
Amlodipine-induced gingival enlargement--a clinical report.
    Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 2012, Volume: 33, Issue:5

    Topics: Amlodipine; Antihypertensive Agents; Calcium Channel Blockers; Female; Gingival Overgrowth; Humans;

2012
Case report: treatment of amlodipine associated gingival overgrowth in periodontitis patients.
    Dentistry today, 2000, Volume: 19, Issue:9

    Topics: Alveolar Bone Loss; Amlodipine; Antihypertensive Agents; Chronic Disease; Dental Calculus; Dental Sc

2000
Risk factors of gingival overgrowth in kidney transplant recipients treated with cyclosporine A.
    Annals of transplantation, 2003, Volume: 8, Issue:4

    Topics: Adult; Alleles; Amlodipine; Calcium Channel Blockers; Cyclosporine; Female; Gingival Overgrowth; HLA

2003
Myeloid sarcoma occurring concurrently with drug-induced gingival enlargement.
    Journal of periodontology, 2006, Volume: 77, Issue:1

    Topics: Amlodipine; Antihypertensive Agents; Biopsy; Diagnosis, Differential; Epithelium; Gingival Neoplasms

2006
The calcium channel blocker used with cyclosporin has an effect on gingival overgrowth.
    Journal of clinical periodontology, 2000, Volume: 27, Issue:2

    Topics: Adult; Amlodipine; Calcium Channel Blockers; Cyclosporine; Drug Therapy, Combination; Female; Gingiv

2000