Page last updated: 2024-10-22

amlodipine and Diabetic Glomerulosclerosis

amlodipine has been researched along with Diabetic Glomerulosclerosis in 71 studies

Amlodipine: A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
amlodipine : A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.

Research Excerpts

ExcerptRelevanceReference
"Inhibition of the rennin-angiotensin system (RAS) could reduce insulin resistance in patients with hypertension and diabetic kidney disease (DKD), but whether the effect of losartan on insulin resistance is associated with reduction of oxidative stress and enhancement of insulin signaling transduction has not been fully elucidated."9.20Losartan reduces insulin resistance by inhibiting oxidative stress and enhancing insulin signaling transduction. ( Fu, SK; Gu, HF; Hu, C; Jin, HM; Liu, XL; Pan, LH; Pan, Y; Qiao, QY; Zhou, DC, 2015)
" In this study, we conducted an open-label and randomized trial to compare the effects of benidipine with those of amlodipine on blood pressure (BP), albuminuria and aldosterone concentration in hypertensive patients with mild-to-moderate stage chronic kidney disease (CKD)."9.15Benidipine reduces albuminuria and plasma aldosterone in mild-to-moderate stage chronic kidney disease with albuminuria. ( Abe, M; Fujita, T; Maruyama, N; Maruyama, T; Matsumoto, K; Matsumoto, S; Okada, K; Soma, M, 2011)
"Forty type 2 diabetic patients with hypertension and nephropathy receiving angiotensin receptor II blockers were enrolled and randomly divided into two groups: the efonidipine group was administered efonidipine hydrochloride ethanolate 40 mg/day and the amlodipine group was admin-istered amlodipine besilate 5 mg/day for 12 months."9.14Protective effects of efonidipine, a T- and L-type calcium channel blocker, on renal function and arterial stiffness in type 2 diabetic patients with hypertension and nephropathy. ( Ban, N; Endo, K; Kawana, H; Miyashita, Y; Nagayama, D; Ohhira, M; Oyama, T; Saiki, A; Sasaki, H; Shirai, K; Yamaguchi, T, 2009)
"In addition to reducing urinary protein excretion, losartan at 100 mg daily increases insulin sensitivity and improves glucose homeostasis in subjects with type 2 diabetic nephropathy."9.12Angiotensin type-1 receptor blockade with losartan increases insulin sensitivity and improves glucose homeostasis in subjects with type 2 diabetes and nephropathy. ( Jin, HM; Pan, Y, 2007)
" The MicroAlbuminuria Reduction With VALsartan (MARVAL) study was designed to evaluate the BP-independent effect of valsartan on UAER in type 2 diabetic patients with microalbuminuria."9.10Microalbuminuria reduction with valsartan in patients with type 2 diabetes mellitus: a blood pressure-independent effect. ( Viberti, G; Wheeldon, NM, 2002)
"In the present quantitative overview of outcome trials, we investigated the efficacy of amlodipine or angiotensin receptor blockers in the prevention of stroke and myocardial infarction in patients with hypertension, coronary artery disease, or diabetic nephropathy."8.84Prevention of stroke and myocardial infarction by amlodipine and Angiotensin receptor blockers: a quantitative overview. ( Franklin, SS; Li, Y; Safar, M; Wang, JG, 2007)
" The authors hypothesized that reduction in aldosterone production in diabetes by amlodipine or aliskiren improves diabetic kidney disease by attenuating renal oxidative stress and fibrosis."7.79Reduction of aldosterone production improves renal oxidative stress and fibrosis in diabetic rats. ( Matavelli, LC; Siragy, HM, 2013)
"The present study assessed the cost effectiveness of irbesartan, an angiotensin II receptor antagonist, and amlodipine, a calcium channel blocker, in the treatment of Canadian patients with diabetic nephropathy and hypertension."7.72Economic evaluation of the use of irbesartan and amlodipine in the treatment of diabetic nephropathy in patients with hypertension in Canada. ( Coyle, D; Rodby, RA, 2004)
" Furthermore, the depletion in glomerular nephrin expression in diabetic animals was only abrogated by valsartan treatment, the therapy which was most effective at retarding the development of albuminuria in this model."7.72Disparate effects of angiotensin II antagonists and calcium channel blockers on albuminuria in experimental diabetes and hypertension: potential role of nephrin. ( Allen, TJ; Cao, Z; Cooper, ME; Davis, BJ; de Gasparo, M; Kawachi, H, 2003)
"Eighty subjects with type 2 diabetic nephropathy were randomly divided into two groups: losarten group (n = 41) and amlodipine group (n = 39)."6.74Adiponectin is positively associated with insulin resistance in subjects with type 2 diabetic nephropathy and effects of angiotensin II type 1 receptor blocker losartan. ( Guo, LL; Jin, HM; Pan, Y, 2009)
"Inhibition of the rennin-angiotensin system (RAS) could reduce insulin resistance in patients with hypertension and diabetic kidney disease (DKD), but whether the effect of losartan on insulin resistance is associated with reduction of oxidative stress and enhancement of insulin signaling transduction has not been fully elucidated."5.20Losartan reduces insulin resistance by inhibiting oxidative stress and enhancing insulin signaling transduction. ( Fu, SK; Gu, HF; Hu, C; Jin, HM; Liu, XL; Pan, LH; Pan, Y; Qiao, QY; Zhou, DC, 2015)
"The aim of this study was to compare the effects of a dihidropiridin calcium channel blocker amlodipin and a non-dihidropiridin calcium channel blocker verapamil on nephropathy and serum pigment epithelium-derived factor (PEDF) levels of type 2 diabetic patients with hypertension."5.20The effects of calcium channel blockers on nephropathy and pigment epithelium-derived factor in the treatment of hypertensive patients with type 2 diabetes mellitus. ( Çelik, H; Korkmaz, H; Oğuz, E; Sabuncu, T; Tabur, S, 2015)
" Intact FGF-23, the eGFR, proteinuria and the endothelium-dependent flow-mediated (FMD) response to ischemia and other parameters were measured at baseline and after 12-weeks of treatment with ramipril (n = 68) or amlodipine (n = 32)."5.19Ramipril lowers plasma FGF-23 in patients with diabetic nephropathy. ( Cetinkaya, H; Eyileten, T; Gok, M; Karaman, M; Kurt, YG; Mallamaci, F; Oguz, Y; Saglam, M; Sonmez, A; Unal, HU; Vural, A; Yilmaz, MI; Zoccali, C, 2014)
"Cilnidipine did not offer greater renoprotection than amlodipine in RAS inhibitor-treated hypertensive patients with type 2 diabetes and microalbuminuria."5.17Comparison of the antialbuminuric effects of L-/N-type and L-type calcium channel blockers in hypertensive patients with diabetes and microalbuminuria: the study of assessment for kidney function by urinary microalbumin in randomized (SAKURA) trial. ( Ando, K; Fujita, T; Kosugi, S; Matsuoka, H; Nakao, K; Sato, T; Tanaka, S; Ueshima, K, 2013)
" In this study, we conducted an open-label and randomized trial to compare the effects of benidipine with those of amlodipine on blood pressure (BP), albuminuria and aldosterone concentration in hypertensive patients with mild-to-moderate stage chronic kidney disease (CKD)."5.15Benidipine reduces albuminuria and plasma aldosterone in mild-to-moderate stage chronic kidney disease with albuminuria. ( Abe, M; Fujita, T; Maruyama, N; Maruyama, T; Matsumoto, K; Matsumoto, S; Okada, K; Soma, M, 2011)
"5-5 mg/day) in olmesartan-treated hypertensive (blood pressure 130-180/80-110 mmHg) patients with type 2 diabetes (fasting blood sugar ≥126 mg/dL or treatment with antidiabetic agents) and albuminuria (urinary albumin/creatinine ratio ≥30 mg/g)."5.15Design and rationale of Japanese evaluation between Formula of Azelnidipine and amlodipine add on olmesartan to Get antialbuminuric effect study (J-FLAG) : evaluation of the antialbuminuric effects between calcium channel blocker with sympatholytic action ( Ando, K; Fujita, T; Haneda, M; Ito, S; Kashihara, N; Kishimoto, J; Nangaku, M; Node, K; Shimosawa, T, 2011)
" To elucidate our hypothesis, we designed a multi-center, open-labeled, randomized trial to compare the antialbuminuric effect between cilnidipine and amlodipine in RAS inhibitor-treated hypertensive (blood pressure [BP]: 130-180/80-110 mmHg) patients with type 2 diabetes and microalbuminuria (urinary albumin/creatinine [Cr] ratio: 30-300 mg/g)."5.15Design and rationale of the study of assessment for kidney function by urinary microalbumin in randomized (SAKURA) trial. ( Ando, K; Babazono, T; Fujita, T; Kario, K; Matsuoka, H; Nakao, K; Tanaka, S; Ueshima, K, 2011)
"Forty type 2 diabetic patients with hypertension and nephropathy receiving angiotensin receptor II blockers were enrolled and randomly divided into two groups: the efonidipine group was administered efonidipine hydrochloride ethanolate 40 mg/day and the amlodipine group was admin-istered amlodipine besilate 5 mg/day for 12 months."5.14Protective effects of efonidipine, a T- and L-type calcium channel blocker, on renal function and arterial stiffness in type 2 diabetic patients with hypertension and nephropathy. ( Ban, N; Endo, K; Kawana, H; Miyashita, Y; Nagayama, D; Ohhira, M; Oyama, T; Saiki, A; Sasaki, H; Shirai, K; Yamaguchi, T, 2009)
" We hypothesized that a trandolapril/verapamil SR (T/V) fixed-dose combination (FDC) was superior to a benazepril/amlodipine (B/A) FDC for reducing albuminuria in 304 hypertensive diabetic nephropathy patients when treated for 36 weeks."5.13Effects of calcium channel blockers on proteinuria in patients with diabetic nephropathy. ( Bacher, P; Champion, A; Fakouhi, K; Tian, M; Toto, RD, 2008)
"In addition to reducing urinary protein excretion, losartan at 100 mg daily increases insulin sensitivity and improves glucose homeostasis in subjects with type 2 diabetic nephropathy."5.12Angiotensin type-1 receptor blockade with losartan increases insulin sensitivity and improves glucose homeostasis in subjects with type 2 diabetes and nephropathy. ( Jin, HM; Pan, Y, 2007)
"Associations between baseline proteinuria and proteinuria reduction by either irbesartan, amlodipine, or control for similar decrements in blood pressure and the cumulative incidence of renal end points were examined using the Kaplan-Meier method in patients enrolled in the Irbesartan Diabetic Nephropathy Trial."5.11Proteinuria reduction and progression to renal failure in patients with type 2 diabetes mellitus and overt nephropathy. ( Atkins, RC; Braden, G; Briganti, EM; Champion de Crespigny, PJ; DeFerrari, G; Drury, P; Hunsicker, LG; Lewis, EJ; Lewis, JB; Locatelli, F; Wiegmann, TB, 2005)
" A new clinical trial, GUARD (Gauging Albuminuria Reduction With Lotrel in Diabetic Patients With Hypertension), is designed to compare the change in urinary albumin to creatinine ratio after 1 year of initial treatment with either amlodipine besylate/benazepril HCl or benazepril HCl/hydrochlorothiazide."5.11Rationale and design of a study comparing two fixed-dose combination regimens to reduce albuminuria in patients with type II diabetes and hypertension. ( Bakris, GL; McCullough, PA; Toto, RD, 2005)
" Using treatment-specific probabilities derived from the Irbesartan in Diabetic Nephropathy Trial (IDNT), the cost effectiveness of treating patients with hypertension, type II diabetes and nephropathy with irbesartan, amlodipine or control was calculated using a Markov model."5.11An economic evaluation of the Irbesartan in Diabetic Nephropathy Trial (IDNT) in a UK setting. ( Annemans, L; Bilous, RW; Lamotte, M; Palmer, AJ; Rodby, RA; Roze, S, 2004)
" The MicroAlbuminuria Reduction With VALsartan (MARVAL) study was designed to evaluate the BP-independent effect of valsartan on UAER in type 2 diabetic patients with microalbuminuria."5.10Microalbuminuria reduction with valsartan in patients with type 2 diabetes mellitus: a blood pressure-independent effect. ( Viberti, G; Wheeldon, NM, 2002)
"In the present quantitative overview of outcome trials, we investigated the efficacy of amlodipine or angiotensin receptor blockers in the prevention of stroke and myocardial infarction in patients with hypertension, coronary artery disease, or diabetic nephropathy."4.84Prevention of stroke and myocardial infarction by amlodipine and Angiotensin receptor blockers: a quantitative overview. ( Franklin, SS; Li, Y; Safar, M; Wang, JG, 2007)
"Currently, AIIAs such as losartan represent the only evidence-based treatment strategy for patients with type 2 DM and proteinuria."4.82Losartan and other angiotensin II antagonists for nephropathy in type 2 diabetes mellitus: a review of the clinical trial evidence. ( Ruilope, LM; Segura, J, 2003)
"SEVERAL MECHANISMS: The progression in renal failure first implies hemodynamic mechanisms and among which angiotensin II has a central role, but also an increase in proteinuria and the induction of many inflammatory and mitogenic mediators that enhance fibrosis (TGF-beta), an effect stimulating the thrombotic mechanism."4.81[The effect of angiotensin-converting enzyme inhibitors on the progression of chronic renal failure]. ( Bernadet-Monrozies, P; Durand, D; Kamar, N; Rostaing, L, 2002)
"The results of this study suggested that the L/N-type CCB, cilnidipine, had additive antihypertensive and proteinuria-lowering effects when administered in combination with an ARB, even in type-1 diabetic rats, and that the L-type CCB, amlodipine, did not."3.79Additive effects of cilnidipine and angiotensin II receptor blocker in preventing the progression of diabetic nephropathy in diabetic spontaneously hypertensive rats. ( Aritomi, S; Konda, T; Niinuma, K; Nitta, K; Ogawa, T, 2013)
" The authors hypothesized that reduction in aldosterone production in diabetes by amlodipine or aliskiren improves diabetic kidney disease by attenuating renal oxidative stress and fibrosis."3.79Reduction of aldosterone production improves renal oxidative stress and fibrosis in diabetic rats. ( Matavelli, LC; Siragy, HM, 2013)
"Diabetic nephropathy is the most common cause of end-stage renal disease (ESRD) in the United States, and accounts for 35% of all the patients with ESRD entering a dialysis program; 63% of patients with diabetic nephropathy have type II diabetes mellitus."3.78Renoprotection and renin-angiotensin system blockade in diabetes mellitus. ( Ruilope, LM, 1997)
"The irbesartan in Diabetic Nephropathy Trial (IDNT) demonstrated that treatment of patients with type 2 diabetes, hypertension and nephropathy with irbesartan resulted in a 20% relative reduction of the composite endpoint of doubling serum creatinine, end-stage renal disease or death as compared with amlodipine and placebo (antihypertensive standard therapy)."3.73[Health economic consequences of the use of irbesartan in patients with type 2 diabetes, hypertension and nephropathy in Switzerland]. ( Burnier, M; Frei, A; Hess, B; Palmer, AJ, 2006)
"Three treatments for hypertension patients with type 2 diabetes mellitus and nephropathy were assessed: (1) irbesartan, (2) amlodipine, and (3) placebo."3.72The cost-effectiveness of irbesartan in the treatment of hypertensive patients with type 2 diabetic nephropathy. ( Annemans, L; Borenstein, J; Chen, RS; Chiou, CF; Lewis, EJ; Palmer, AJ; Rodby, RA; Roze, S; Sengupta, N; Simon, TA; Smitten, A, 2003)
"Treating patients with hypertension, type 2 diabetes and nephropathy using irbesartan lowers the cumulative incidence of ESRD and is cost-saving compared to amlodipine or control."3.72[Health economic consequences of the use of irbesartan in patients in Germany with type 2 diabetes, nephropathy and hypertension]. ( Annemans, L; Lamotte, M; Palmer, AJ; Ritz, E; Rodby, RA; Roze, S, 2004)
" Furthermore, the depletion in glomerular nephrin expression in diabetic animals was only abrogated by valsartan treatment, the therapy which was most effective at retarding the development of albuminuria in this model."3.72Disparate effects of angiotensin II antagonists and calcium channel blockers on albuminuria in experimental diabetes and hypertension: potential role of nephrin. ( Allen, TJ; Cao, Z; Cooper, ME; Davis, BJ; de Gasparo, M; Kawachi, H, 2003)
"The present study assessed the cost effectiveness of irbesartan, an angiotensin II receptor antagonist, and amlodipine, a calcium channel blocker, in the treatment of Canadian patients with diabetic nephropathy and hypertension."3.72Economic evaluation of the use of irbesartan and amlodipine in the treatment of diabetic nephropathy in patients with hypertension in Canada. ( Coyle, D; Rodby, RA, 2004)
"However, the effects of BDNF on diabetic nephropathy are unknown."2.80Assessment of glomerular filtration rate based on alterations of serum brain-derived neurotrophic factor in type 2 diabetic subjects treated with amlodipine/benazepril or valsartan/hydrochlorothiazide. ( Chen, JF; Hung, YJ; Lee, IT; Lee, WJ; Sheu, WH; Wang, CY, 2015)
"Seventy-six patients with type 2 diabetes and DKD (all with albuminuria and serum creatinine <1."2.78Effect of renin-angiotensin system blockade on soluble Klotho in patients with type 2 diabetes, systolic hypertension, and albuminuria. ( Gnudi, L; Hill, B; Karalliedde, J; Maltese, G; Viberti, G, 2013)
"Eighty subjects with type 2 diabetic nephropathy were randomly divided into two groups: losarten group (n = 41) and amlodipine group (n = 39)."2.74Adiponectin is positively associated with insulin resistance in subjects with type 2 diabetic nephropathy and effects of angiotensin II type 1 receptor blocker losartan. ( Guo, LL; Jin, HM; Pan, Y, 2009)
"Amlodipine and ramipril were added to their previous antihypertensive treatment for 12 weeks."2.72Urinary TGF-beta1 reduction related to a decrease of systolic blood pressure in patients with type 2 diabetes and clinical diabetic nephropathy. ( Bertoluci, MC; Oliveira, FR; Schmid, H; Schmidt, A; Thomazelli, FC; Uebel, D, 2006)
"All participants had baseline diabetic nephropathy, overt proteinuria, and hypertension and were recruited between 1996 and 1999."2.71Total plasma homocysteine and arteriosclerotic outcomes in type 2 diabetes with nephropathy. ( Bostom, AG; Friedman, AN; Hunsicker, LG; Selhub, J, 2005)
"Twenty-eight patients who had type 1 diabetes and known diabetic renal disease and had a persistently elevated albumin creatinine ratio (ACR) > 10 mg/mmol despite office BP recordings < or = 140/80 mmHg on maximal recommended dose of the ACEI lisinopril were studied."2.71Targeting albumin excretion rate in the treatment of the hypertensive diabetic patient with renal disease. ( Bilous, R; Karalliedde, J; Krimholtz, MJ; Thomas, S; Viberti, G, 2005)
"1715 adults with type 2 diabetic nephropathy and hypertension; serum creatinine levels of 89 micromol/L (1."2.71Cardiovascular outcomes in the Irbesartan Diabetic Nephropathy Trial of patients with type 2 diabetes and overt nephropathy. ( Berl, T; Drury, PL; Esmatjes, E; Goldhaber, SZ; Hricik, D; Hunsicker, LG; Lewis, EJ; Lewis, JB; Locatelli, F; Parikh, CR; Pfeffer, MA; Porush, JG; Raz, I; Rouleau, JL; Vanhille, P; Wiegmann, TB; Wolfe, BM, 2003)
"Diabetic nephropathy is the most common cause of end-stage renal disease in the developed world."2.69The Irbesartan type II diabetic nephropathy trial: study design and baseline patient characteristics. For the Collaborative Study Group. ( Anzalone, DA; Atkins, RC; Clarke, WR; Hunsicker, LG; Lewis, EJ; Ritz, E; Rodby, RA; Rohde, RD, 2000)
"Of the hypertensive NIDDM patients attending the outpatient's clinic of the internal medicine departments of the University of Padova and Sassari, 44 participated in the present study."2.68Effects of cilazapril and amlodipine on kidney function in hypertensive NIDDM patients. ( Brocco, E; Carraro, A; Cernigoi, AM; Fioretto, P; Fresu, P; Frigato, F; Maioli, M; Muollo, B; Nosadini, R; Tonolo, G; Velussi, M; Zolli, M, 1996)
"Amlodipine is a classical drug with varied properties extending from control of blood pressure to as an antianginal and anti atherosclerotic agent."2.58Amlodipine in the Era of New Generation Calcium Channel Blockers. ( Kashyap, R; Langote, A; Tiwaskar, M; Toppo, A, 2018)
"Patients with type 2 diabetes and diabetic nephropathy have a dramatically increased cardiovascular risk."2.42Treatment of diabetic nephropathy with angiotensin II receptor antagonist. ( Lewis, EJ; Lewis, JB, 2003)
" Therefore, the results of valsartan and amlodipine tablets combined with alpha-lipoic acid on total antioxidant capacity (T-AOC) need to be investigated."1.91Effects of Valsartan and Amlodipine Tablets Combined with α-Lipoic Acid on T-AOC, IL-6 and β2-MG Levels in Patients with Diabetic Nephropathy. ( Su, F; Xia, Q, 2023)
"The Irbesartan Diabetic Nephropathy Trial (IDNT) demonstrated that irbesartan significantly slowed established Type 2 diabetic nephropathy progression."1.38Irbesartan delays progression of nephropathy as measured by estimated glomerular filtration rate: post hoc analysis of the Irbesartan Diabetic Nephropathy Trial. ( Bain, SC; Bilous, RW; Evans, M; Hogan, S, 2012)
"Ramipril treatment was associated with a significantly lower risk of DM in African Americans with hypertensive kidney disease than amlodipine or metoprolol treatment."1.33Differing effects of antihypertensive drugs on the incidence of diabetes mellitus among patients with hypertensive kidney disease. ( Agodoa, LY; Appel, LJ; Cheek, D; Contreras, G; Gassman, J; Lash, JP; Miller, ER; Randall, OS; Thornley-Brown, D; Wang, X; Wright, JT, 2006)
"Diabetic nephropathy is associated with increased albuminuria and accumulation of extracellular matrix proteins within the kidney."1.32Calcium channel blockers, either amlodipine or mibefradil, ameliorate renal injury in experimental diabetes. ( Allen, TJ; Cao, Z; Cooper, ME; Ma, G, 2004)
"To investigate the effects of the mixed endothelin receptor antagonist, bosentan, combined with the long-acting calcium channel blocker, amlodipine, compared to the angiotensin-converting enzyme inhibitor, cilazapril, on the progressive renal injury in spontaneous hypertensive rats (SHR) with diabetes."1.31Endothelin receptor antagonist combined with a calcium channel blocker attenuates renal injury in spontaneous hypertensive rats with diabetes. ( Chen, J; Gu, Y; Lin, F; Lin, S; Ma, J; Yang, H; Zhu, W, 2002)
"Imidapril treatment significantly decreased urinary albumin excretions and improved glomerulosclerosis of OLETF rats, while amlodipine failed to improve nephropathy of OLETF rats despite lowering of blood pressure."1.31Role of intrarenal angiotensin-converting enzyme in nephropathy of type II diabetic rats. ( Iwao, H; Kim, S; Taniguchi, M; Zhan, Y, 2002)

Research

Studies (71)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (2.82)18.2507
2000's46 (64.79)29.6817
2010's22 (30.99)24.3611
2020's1 (1.41)2.80

Authors

AuthorsStudies
Su, F1
Xia, Q1
Tiwaskar, M1
Langote, A1
Kashyap, R1
Toppo, A1
Jeon, SY1
Lee, NR1
Yim, CY1
Karalliedde, J2
Maltese, G1
Hill, B1
Viberti, G3
Gnudi, L1
Ando, K3
Ueshima, K2
Tanaka, S2
Kosugi, S1
Sato, T1
Matsuoka, H2
Nakao, K2
Fujita, T5
Tabur, S1
Oğuz, E1
Sabuncu, T1
Korkmaz, H1
Çelik, H1
Uchida, S1
Takahashi, M1
Sugawara, M1
Saito, T1
Nakai, K1
Fujita, M1
Mochizuki, K1
Shin, I1
Morita, T1
Hikita, T1
Itakura, H1
Takahashi, Y1
Mizuno, S1
Ohno, Y1
Ito, K1
Ito, T1
Soma, M3
Yilmaz, MI2
Sonmez, A2
Saglam, M2
Kurt, YG1
Unal, HU1
Karaman, M1
Gok, M1
Cetinkaya, H1
Eyileten, T2
Oguz, Y1
Vural, A1
Mallamaci, F1
Zoccali, C1
Pan, Y3
Qiao, QY1
Pan, LH1
Zhou, DC1
Hu, C1
Gu, HF1
Fu, SK1
Liu, XL1
Jin, HM3
Lee, IT1
Sheu, WH1
Hung, YJ1
Chen, JF1
Wang, CY1
Lee, WJ1
Toto, RD3
Tian, M1
Fakouhi, K1
Champion, A1
Bacher, P1
Guo, LL1
Khan, AH1
Sattar, MA2
Abdullah, NA2
Johns, EJ2
Sasaki, H1
Saiki, A1
Endo, K1
Ban, N1
Yamaguchi, T1
Kawana, H1
Nagayama, D1
Ohhira, M1
Oyama, T1
Miyashita, Y1
Shirai, K1
Khan, MA1
Abdulla, MH1
Salman, IM1
Kazi, RN1
Swarup, KR1
Rathore, HA1
Basri, F1
Hussain, NM1
Dewa, A1
Carrero, JJ1
Martín-Ventura, JL1
Celik, T1
Yaman, H1
Yenicesu, M1
Moreno, JA1
Egido, J1
Blanco-Colio, LM1
Sepehr-Ara, L1
Sepehr-Ara, M1
Mahmoudian, M1
Abe, M2
Okada, K2
Maruyama, N2
Matsumoto, S1
Maruyama, T1
Matsumoto, K1
Holtkamp, FA1
de Zeeuw, D1
de Graeff, PA1
Laverman, GD1
Berl, T3
Remuzzi, G2
Packham, D1
Lewis, JB5
Parving, HH1
Lambers Heerspink, HJ1
Haneda, M1
Ito, S1
Kashihara, N1
Node, K1
Nangaku, M1
Shimosawa, T1
Kishimoto, J1
Babazono, T1
Kario, K1
Hiroo, K1
Oda, T1
Kushiyama, T1
Higashi, K1
Yamamoto, K1
Rodríguez-Pérez, JC1
García-Bello, MA1
Anabitarte-Prieto, A1
Companioni, O1
Nóvoa-Mogollón, FJ1
Suárez-Ortega, S1
Plaza-Toledano, C1
Rodríguez-Esparragón, F1
Fujita, H1
Fujishima, H1
Morii, T1
Sakamoto, T1
Komatsu, K1
Hosoba, M1
Narita, T1
Takahashi, K1
Takahashi, T1
Yamada, Y1
Evans, M1
Bain, SC1
Hogan, S1
Bilous, RW2
Suzuki, H2
Fujii, Y1
Ito, M1
Yoshida, Y1
Aritomi, S1
Niinuma, K1
Ogawa, T1
Konda, T1
Nitta, K1
Matavelli, LC1
Siragy, HM1
Chen, J1
Gu, Y1
Lin, F1
Yang, H1
Zhu, W1
Ma, J1
Lin, S1
Wheeldon, NM1
Bernadet-Monrozies, P1
Rostaing, L1
Kamar, N1
Durand, D1
Kuriyama, S1
Tomonari, H1
Tokudome, G1
Horiguchi, M1
Hayashi, H1
Kobayashi, H1
Ishikawa, M1
Hosoya, T1
Davis, BJ1
Cao, Z2
de Gasparo, M1
Kawachi, H1
Cooper, ME2
Allen, TJ2
Hunsicker, LG7
Pfeffer, MA1
Porush, JG1
Rouleau, JL1
Drury, PL1
Esmatjes, E2
Hricik, D1
Parikh, CR1
Raz, I2
Vanhille, P1
Wiegmann, TB2
Wolfe, BM1
Locatelli, F2
Goldhaber, SZ1
Lewis, EJ8
Rodby, RA7
Chiou, CF1
Borenstein, J1
Smitten, A1
Sengupta, N1
Palmer, AJ4
Roze, S3
Annemans, L3
Simon, TA1
Chen, RS1
Lamotte, M2
Ritz, E4
Ruilope, LM2
Segura, J1
Coyle, D1
Lehfeld, LS1
Silveira, LA1
Ghini, B1
Lopes de Faria, JB1
Ma, G1
Bakris, GL2
McCullough, PA2
Atkins, RC3
Briganti, EM1
Braden, G1
Champion de Crespigny, PJ1
DeFerrari, G2
Drury, P1
Krimholtz, MJ1
Thomas, S1
Bilous, R1
Pohl, MA2
Blumenthal, S1
Cordonnier, DJ1
De Alvaro, F1
Eisner, G1
Gilbert, RE1
de Faria, JB1
Mangili, R1
Moore, J1
Reisin, E1
Schernthaner, G1
Spitalewitz, S1
Tindall, H1
Friedman, AN1
Selhub, J1
Bostom, AG1
Bertoluci, MC1
Uebel, D1
Schmidt, A1
Thomazelli, FC1
Oliveira, FR1
Schmid, H1
Frei, A1
Burnier, M1
Hess, B1
Thornley-Brown, D1
Wang, X1
Wright, JT1
Randall, OS1
Miller, ER1
Lash, JP1
Gassman, J1
Contreras, G1
Appel, LJ1
Agodoa, LY1
Cheek, D1
Ruggenenti, P1
Wang, JG1
Li, Y1
Franklin, SS1
Safar, M1
Bönner, G1
Rocha, R1
Purkayastha, D1
Davis, P1
Busch, M1
Franke, S1
Wolf, G1
Rohde, RD2
Stein, G1
Velussi, M1
Brocco, E1
Frigato, F1
Zolli, M1
Muollo, B1
Maioli, M1
Carraro, A1
Tonolo, G1
Fresu, P1
Cernigoi, AM1
Fioretto, P1
Nosadini, R1
Clarke, WR2
Anzalone, DA1
Shigihara, T1
Sato, A1
Hayashi, K1
Saruta, T1
Satomura, A1
Hidaka, M1
Ohsawa, I1
Endo, M1
Ohi, H1
Rohde, R1
Studney, D1
Taniguchi, M1
Kim, S1
Zhan, Y1
Iwao, H1
Os, I1
Stenehjem, A1
Høieggen, A1
Draganov, B1
Jenssen, T1
Holdaas, H1

Clinical Trials (10)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE): The Role of Angiotensin-(1-7) in Hypertension and Hypertension-Induced Heart and Kidney Damage[NCT04752293]125 participants (Anticipated)Observational2021-05-19Recruiting
A 24-week Study to Evaluate the Effectiveness of Valsartan in Combination With Hydrochlorothiazide Versus Amlodipine on Arterial Compliance in Patients With Hypertension, Type 2 Diabetes and Albuminuria[NCT00171561]Phase 4144 participants (Actual)Interventional2003-03-31Completed
Evaluation of Hematologic Patients - Training Protocol[NCT00001715]898 participants (Actual)Observational1998-04-21Completed
[NCT01738945]Phase 432 participants (Actual)Interventional2008-02-29Completed
Adiponectin is Positively Associated With Insulin Resistance in Subjects With Type 2 Diabetic Nephropathy and Effects by Angiotensin Type 1 Receptor Blocker Losartan[NCT00774904]80 participants (Actual)Interventional2007-04-30Completed
The Effects of Renin Angiotensin System Blockage (RAS), Calcium Channel Blocker and Combine Drugs on TWEAK, PTX3 and FMD Levels in Diabetic Proteinuric Patients With Hypertension[NCT00921570]Phase 4105 participants (Actual)Interventional2008-02-29Completed
Medication Adherence Given Individual SystemCHANGE(TM) in Advancing Nephropathy (MAGICIAN) Pilot Study[NCT04616612]150 participants (Anticipated)Interventional2021-12-15Recruiting
[NCT00021918]0 participants Observational2001-04-30Completed
Open, Randomized, Unicenter Study Comparing Metabolic Surgery With Intensive Medical Therapy to Treat Diabetic Kidney Disease[NCT04626323]Phase 260 participants (Anticipated)Interventional2021-05-25Recruiting
Determinants of Diabetic Nephropathy in American Indians[NCT01878045]141 participants (Actual)Observational2013-11-07Suspended (stopped due to This study is on a temporary Administrative Hold pending further discussion for NIDDK and Tribal Leadership.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

10 reviews available for amlodipine and Diabetic Glomerulosclerosis

ArticleYear
Amlodipine in the Era of New Generation Calcium Channel Blockers.
    The Journal of the Association of Physicians of India, 2018, Volume: 66, Issue:3

    Topics: Albuminuria; Amlodipine; Atherosclerosis; Calcium Channel Blockers; Diabetes Complications; Diabetic

2018
Albuminuria and blood pressure, independent targets for cardioprotective therapy in patients with diabetes and nephropathy: a post hoc analysis of the combined RENAAL and IDNT trials.
    European heart journal, 2011, Volume: 32, Issue:12

    Topics: Aged; Albuminuria; Amlodipine; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Pressure;

2011
[Large scale clinical trials in prevention of end-stage renal disease due to type 2 diabetes with angiotensin receptor antagonists].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60, Issue:10

    Topics: Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Biphenyl Compounds; Clinical Trials as Topic;

2002
[The effect of angiotensin-converting enzyme inhibitors on the progression of chronic renal failure].
    Presse medicale (Paris, France : 1983), 2002, Nov-09, Volume: 31, Issue:36

    Topics: Amlodipine; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibito

2002
Treatment of diabetic nephropathy with angiotensin II receptor antagonist.
    Clinical and experimental nephrology, 2003, Volume: 7, Issue:1

    Topics: Amlodipine; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Creatinin

2003
Losartan and other angiotensin II antagonists for nephropathy in type 2 diabetes mellitus: a review of the clinical trial evidence.
    Clinical therapeutics, 2003, Volume: 25, Issue:12

    Topics: Albuminuria; Amlodipine; Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Clinical Trial

2003
Prevention of stroke and myocardial infarction by amlodipine and Angiotensin receptor blockers: a quantitative overview.
    Hypertension (Dallas, Tex. : 1979), 2007, Volume: 50, Issue:1

    Topics: Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Coronary Artery

2007
Renoprotection and renin-angiotensin system blockade in diabetes mellitus.
    American journal of hypertension, 1997, Volume: 10, Issue:12 Pt 2

    Topics: Amlodipine; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Diabetic

1997
Angiotensin blockade in type 2 diabetes: what the new evidence tells us about renal and cardiac complications.
    The Canadian journal of cardiology, 2002, Volume: 18 Suppl A

    Topics: Albuminuria; Amlodipine; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors;

2002
[Type 2 diabetes and nephropathy--new studies, new treatment strategies?].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2002, Apr-10, Volume: 122, Issue:9

    Topics: Amlodipine; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calci

2002

Trials

37 trials available for amlodipine and Diabetic Glomerulosclerosis

ArticleYear
Effect of renin-angiotensin system blockade on soluble Klotho in patients with type 2 diabetes, systolic hypertension, and albuminuria.
    Clinical journal of the American Society of Nephrology : CJASN, 2013, Volume: 8, Issue:11

    Topics: Aged; Albuminuria; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Biomarkers; Blood Pressure;

2013
Effect of renin-angiotensin system blockade on soluble Klotho in patients with type 2 diabetes, systolic hypertension, and albuminuria.
    Clinical journal of the American Society of Nephrology : CJASN, 2013, Volume: 8, Issue:11

    Topics: Aged; Albuminuria; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Biomarkers; Blood Pressure;

2013
Effect of renin-angiotensin system blockade on soluble Klotho in patients with type 2 diabetes, systolic hypertension, and albuminuria.
    Clinical journal of the American Society of Nephrology : CJASN, 2013, Volume: 8, Issue:11

    Topics: Aged; Albuminuria; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Biomarkers; Blood Pressure;

2013
Effect of renin-angiotensin system blockade on soluble Klotho in patients with type 2 diabetes, systolic hypertension, and albuminuria.
    Clinical journal of the American Society of Nephrology : CJASN, 2013, Volume: 8, Issue:11

    Topics: Aged; Albuminuria; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Biomarkers; Blood Pressure;

2013
Effect of renin-angiotensin system blockade on soluble Klotho in patients with type 2 diabetes, systolic hypertension, and albuminuria.
    Clinical journal of the American Society of Nephrology : CJASN, 2013, Volume: 8, Issue:11

    Topics: Aged; Albuminuria; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Biomarkers; Blood Pressure;

2013
Effect of renin-angiotensin system blockade on soluble Klotho in patients with type 2 diabetes, systolic hypertension, and albuminuria.
    Clinical journal of the American Society of Nephrology : CJASN, 2013, Volume: 8, Issue:11

    Topics: Aged; Albuminuria; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Biomarkers; Blood Pressure;

2013
Effect of renin-angiotensin system blockade on soluble Klotho in patients with type 2 diabetes, systolic hypertension, and albuminuria.
    Clinical journal of the American Society of Nephrology : CJASN, 2013, Volume: 8, Issue:11

    Topics: Aged; Albuminuria; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Biomarkers; Blood Pressure;

2013
Effect of renin-angiotensin system blockade on soluble Klotho in patients with type 2 diabetes, systolic hypertension, and albuminuria.
    Clinical journal of the American Society of Nephrology : CJASN, 2013, Volume: 8, Issue:11

    Topics: Aged; Albuminuria; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Biomarkers; Blood Pressure;

2013
Effect of renin-angiotensin system blockade on soluble Klotho in patients with type 2 diabetes, systolic hypertension, and albuminuria.
    Clinical journal of the American Society of Nephrology : CJASN, 2013, Volume: 8, Issue:11

    Topics: Aged; Albuminuria; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Biomarkers; Blood Pressure;

2013
Comparison of the antialbuminuric effects of L-/N-type and L-type calcium channel blockers in hypertensive patients with diabetes and microalbuminuria: the study of assessment for kidney function by urinary microalbumin in randomized (SAKURA) trial.
    International journal of medical sciences, 2013, Volume: 10, Issue:9

    Topics: Aged; Albuminuria; Amlodipine; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Ca

2013
The effects of calcium channel blockers on nephropathy and pigment epithelium-derived factor in the treatment of hypertensive patients with type 2 diabetes mellitus.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2015, Volume: 37, Issue:3

    Topics: Aged; Albuminuria; Amlodipine; Blood Pressure; Calcium Channel Blockers; Creatinine; Diabetes Mellit

2015
Effects of the N/L-type calcium channel blocker cilnidipine on nephropathy and uric acid metabolism in hypertensive patients with chronic kidney disease (J-CIRCLE study).
    Journal of clinical hypertension (Greenwich, Conn.), 2014, Volume: 16, Issue:10

    Topics: Aged; Aged, 80 and over; Albuminuria; Amlodipine; Blood Pressure; Calcium Channel Blockers; Creatini

2014
Ramipril lowers plasma FGF-23 in patients with diabetic nephropathy.
    American journal of nephrology, 2014, Volume: 40, Issue:3

    Topics: Adult; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Diabetes Mellitus, Type

2014
Losartan reduces insulin resistance by inhibiting oxidative stress and enhancing insulin signaling transduction.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2015, Volume: 123, Issue:3

    Topics: 3T3-L1 Cells; Adipocytes; Aged; Amlodipine; Animals; Antihypertensive Agents; Diabetic Nephropathies

2015
Assessment of glomerular filtration rate based on alterations of serum brain-derived neurotrophic factor in type 2 diabetic subjects treated with amlodipine/benazepril or valsartan/hydrochlorothiazide.
    Disease markers, 2015, Volume: 2015

    Topics: Aged; Amlodipine; Antihypertensive Agents; Benzazepines; Brain-Derived Neurotrophic Factor; Diabetes

2015
Effects of calcium channel blockers on proteinuria in patients with diabetic nephropathy.
    Journal of clinical hypertension (Greenwich, Conn.), 2008, Volume: 10, Issue:10

    Topics: Aged; Albuminuria; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Be

2008
Adiponectin is positively associated with insulin resistance in subjects with type 2 diabetic nephropathy and effects of angiotensin II type 1 receptor blocker losartan.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Volume: 24, Issue:6

    Topics: Adiponectin; Adult; Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Diabe

2009
Protective effects of efonidipine, a T- and L-type calcium channel blocker, on renal function and arterial stiffness in type 2 diabetic patients with hypertension and nephropathy.
    Journal of atherosclerosis and thrombosis, 2009, Volume: 16, Issue:5

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Aldosterone; Amlodipine; Arteries; Calcium Channel Blockers; Calc

2009
Combined therapy with renin-angiotensin system and calcium channel blockers in type 2 diabetic hypertensive patients with proteinuria: effects on soluble TWEAK, PTX3, and flow-mediated dilation.
    Clinical journal of the American Society of Nephrology : CJASN, 2010, Volume: 5, Issue:7

    Topics: Adult; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; C-Reactive Prot

2010
Benidipine reduces albuminuria and plasma aldosterone in mild-to-moderate stage chronic kidney disease with albuminuria.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2011, Volume: 34, Issue:2

    Topics: Aged; Albuminuria; Aldosterone; Amlodipine; Angiotensin Receptor Antagonists; Blood Pressure; Calciu

2011
Design and rationale of Japanese evaluation between Formula of Azelnidipine and amlodipine add on olmesartan to Get antialbuminuric effect study (J-FLAG) : evaluation of the antialbuminuric effects between calcium channel blocker with sympatholytic action
    Cardiovascular drugs and therapy, 2011, Volume: 25, Issue:4

    Topics: Adult; Aged; Albuminuria; Amlodipine; Azetidinecarboxylic Acid; Calcium Channel Blockers; Diabetic N

2011
Design and rationale of the study of assessment for kidney function by urinary microalbumin in randomized (SAKURA) trial.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2011, Volume: 33, Issue:7

    Topics: Aged; Albuminuria; Amlodipine; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels,

2011
[The Shiga Microalbuminuria Reduction Trial].
    Nihon rinsho. Japanese journal of clinical medicine, 2010, Volume: 68 Suppl 9

    Topics: Albuminuria; Amlodipine; Animals; Antihypertensive Agents; Diabetes Mellitus, Type 2; Diabetic Nephr

2010
Anti-albuminuric effects of the angiotensin AT1 receptor blocker telmisartan in hypertensive patients.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2011, Volume: 33, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Albuminuria; Amlodipine; Angiotensin II Type 1 Receptor Blockers; An

2011
Additive renoprotective effects of aliskiren on angiotensin receptor blocker and calcium channel blocker treatments for type 2 diabetic patients with albuminuria.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2012, Volume: 35, Issue:8

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Aged; Albuminuria; Aldosterone; Amides; Amlodipine; Angiotensin

2012
Microalbuminuria reduction with valsartan in patients with type 2 diabetes mellitus: a blood pressure-independent effect.
    Circulation, 2002, Aug-06, Volume: 106, Issue:6

    Topics: Adult; Aged; Albuminuria; Amlodipine; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blo

2002
Antiproteinuric effects of combined antihypertensive therapies in patients with overt type 2 diabetic nephropathy.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2002, Volume: 25, Issue:6

    Topics: Aged; Amlodipine; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihy

2002
Cardiovascular outcomes in the Irbesartan Diabetic Nephropathy Trial of patients with type 2 diabetes and overt nephropathy.
    Annals of internal medicine, 2003, Apr-01, Volume: 138, Issue:7

    Topics: Amlodipine; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Comp

2003
An economic evaluation of the Irbesartan in Diabetic Nephropathy Trial (IDNT) in a UK setting.
    Journal of human hypertension, 2004, Volume: 18, Issue:10

    Topics: Amlodipine; Antihypertensive Agents; Biphenyl Compounds; Cohort Studies; Cost-Benefit Analysis; Diab

2004
Rationale and design of a study comparing two fixed-dose combination regimens to reduce albuminuria in patients with type II diabetes and hypertension.
    Journal of human hypertension, 2005, Volume: 19, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Albuminuria; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; A

2005
Proteinuria reduction and progression to renal failure in patients with type 2 diabetes mellitus and overt nephropathy.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 45, Issue:2

    Topics: Adult; Aged; Amlodipine; Biphenyl Compounds; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Nep

2005
Targeting albumin excretion rate in the treatment of the hypertensive diabetic patient with renal disease.
    Journal of the American Society of Nephrology : JASN, 2005, Volume: 16 Suppl 1

    Topics: Adult; Aged; Albuminuria; Amlodipine; Benzimidazoles; Biphenyl Compounds; Cross-Over Studies; Diabet

2005
Independent and additive impact of blood pressure control and angiotensin II receptor blockade on renal outcomes in the irbesartan diabetic nephropathy trial: clinical implications and limitations.
    Journal of the American Society of Nephrology : JASN, 2005, Volume: 16, Issue:10

    Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Biphenyl Compounds; Di

2005
Total plasma homocysteine and arteriosclerotic outcomes in type 2 diabetes with nephropathy.
    Journal of the American Society of Nephrology : JASN, 2005, Volume: 16, Issue:11

    Topics: Aged; Amlodipine; Antihypertensive Agents; Arteriosclerosis; Biphenyl Compounds; Cardiovascular Syst

2005
Urinary TGF-beta1 reduction related to a decrease of systolic blood pressure in patients with type 2 diabetes and clinical diabetic nephropathy.
    Diabetes research and clinical practice, 2006, Volume: 72, Issue:3

    Topics: Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Atenolol; Blood Gluco

2006
Angiotensin type-1 receptor blockade with losartan increases insulin sensitivity and improves glucose homeostasis in subjects with type 2 diabetes and nephropathy.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2007, Volume: 22, Issue:7

    Topics: Adult; Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Blood Glucose; C-Peptide; Calcium

2007
Effects of different ACE inhibitor combinations on albuminuria: results of the GUARD study.
    Kidney international, 2008, Volume: 73, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Albuminuria; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; A

2008
Serum levels of the advanced glycation end products Nepsilon-carboxymethyllysine and pentosidine are not influenced by treatment with the angiotensin receptor II type 1 blocker irbesartan in patients with type 2 diabetic nephropathy and hypertension.
    Nephron. Clinical practice, 2008, Volume: 108, Issue:4

    Topics: Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Arginine; Biphen

2008
Effects of cilazapril and amlodipine on kidney function in hypertensive NIDDM patients.
    Diabetes, 1996, Volume: 45, Issue:2

    Topics: Adult; Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pr

1996
Renoprotection and renin-angiotensin system blockade in diabetes mellitus.
    American journal of hypertension, 1997, Volume: 10, Issue:12 Pt 2

    Topics: Amlodipine; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Diabetic

1997
The Irbesartan type II diabetic nephropathy trial: study design and baseline patient characteristics. For the Collaborative Study Group.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2000, Volume: 15, Issue:4

    Topics: Adult; Aged; Amlodipine; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compoun

2000
Effect of combination therapy of angiotensin-converting enzyme inhibitor plus calcium channel blocker on urinary albumin excretion in hypertensive microalbuminuric patients with type II diabetes.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2000, Volume: 23, Issue:3

    Topics: Aged; Albuminuria; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Cha

2000
Angiotensin-converting enzyme inhibitors improve nephrosis more quickly than calcium antagonists in diabetic patients.
    Nephron, 2000, Volume: 86, Issue:4

    Topics: Adult; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel Blocker

2000
Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes.
    The New England journal of medicine, 2001, Sep-20, Volume: 345, Issue:12

    Topics: Adult; Aged; Amlodipine; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compoun

2001
Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes.
    The New England journal of medicine, 2001, Sep-20, Volume: 345, Issue:12

    Topics: Adult; Aged; Amlodipine; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compoun

2001
Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes.
    The New England journal of medicine, 2001, Sep-20, Volume: 345, Issue:12

    Topics: Adult; Aged; Amlodipine; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compoun

2001
Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes.
    The New England journal of medicine, 2001, Sep-20, Volume: 345, Issue:12

    Topics: Adult; Aged; Amlodipine; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compoun

2001
A clinical trial in type 2 diabetic nephropathy.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2001, Volume: 38, Issue:4 Suppl 1

    Topics: Adult; Aged; Amlodipine; Angiotensin Receptor Antagonists; Biphenyl Compounds; Calcium Channel Block

2001

Other Studies

25 other studies available for amlodipine and Diabetic Glomerulosclerosis

ArticleYear
Effects of Valsartan and Amlodipine Tablets Combined with α-Lipoic Acid on T-AOC, IL-6 and β2-MG Levels in Patients with Diabetic Nephropathy.
    Alternative therapies in health and medicine, 2023, Volume: 29, Issue:5

    Topics: Amlodipine; Antihypertensive Agents; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Nephropathies

2023
Successful re-administration of Pazopanib in a patient with metastatic renal cell carcinoma and a history of Pazopanib-induced nephrotic syndrome: a case report.
    BMC nephrology, 2019, 01-03, Volume: 20, Issue:1

    Topics: Aged; Amlodipine; Angiogenesis Inhibitors; Antihypertensive Agents; Antineoplastic Agents; Carcinoma

2019
Effect of calcium channel blockade on adrenergically induced renal vasoconstriction in rat models of renal impairment.
    Clinical and experimental pharmacology & physiology, 2009, Volume: 36, Issue:5-6

    Topics: Amlodipine; Animals; Calcium Channel Blockers; Diabetic Nephropathies; Disease Models, Animal; Drug

2009
Functional subtypes of renal alpha1-adrenoceptor in spontaneously hypertensive rats with streptozotocin-induced experimental diabetic nephropathy.
    Kidney & blood pressure research, 2009, Volume: 32, Issue:5

    Topics: Adrenergic Antagonists; Amlodipine; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies

2009
Effect of the two new calcium channel blockers mebudipine and dibudipine in comparison to amlodipine on vascular flow of isolated kidney of diabetic rat.
    Acta physiologica Hungarica, 2010, Volume: 97, Issue:3

    Topics: Amlodipine; Animals; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus, Experimental; Diab

2010
Modulation of renal superoxide dismutase by telmisartan therapy in C57BL/6-Ins2(Akita) diabetic mice.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2012, Volume: 35, Issue:2

    Topics: Acetophenones; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents

2012
Irbesartan delays progression of nephropathy as measured by estimated glomerular filtration rate: post hoc analysis of the Irbesartan Diabetic Nephropathy Trial.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2012, Volume: 27, Issue:6

    Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Creatinine; Di

2012
Additive effects of cilnidipine and angiotensin II receptor blocker in preventing the progression of diabetic nephropathy in diabetic spontaneously hypertensive rats.
    Clinical and experimental nephrology, 2013, Volume: 17, Issue:1

    Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Biomarkers; B

2013
Reduction of aldosterone production improves renal oxidative stress and fibrosis in diabetic rats.
    Journal of cardiovascular pharmacology, 2013, Volume: 61, Issue:1

    Topics: Aldosterone; Amides; Amlodipine; Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Cy

2013
Endothelin receptor antagonist combined with a calcium channel blocker attenuates renal injury in spontaneous hypertensive rats with diabetes.
    Chinese medical journal, 2002, Volume: 115, Issue:7

    Topics: Amlodipine; Angiotensin II; Animals; Bosentan; Calcium Channel Blockers; Collagen Type IV; Diabetic

2002
Disparate effects of angiotensin II antagonists and calcium channel blockers on albuminuria in experimental diabetes and hypertension: potential role of nephrin.
    Journal of hypertension, 2003, Volume: 21, Issue:1

    Topics: Albuminuria; Amlodipine; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood P

2003
Summaries for patients. Effects of blood pressure drugs in patients with diabetes and kidney disease.
    Annals of internal medicine, 2003, Apr-01, Volume: 138, Issue:7

    Topics: Amlodipine; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Comp

2003
The cost-effectiveness of irbesartan in the treatment of hypertensive patients with type 2 diabetic nephropathy.
    Clinical therapeutics, 2003, Volume: 25, Issue:7

    Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Biphenyl Compounds; Cost-Benefit Analysis; Diabete

2003
[Health economic consequences of the use of irbesartan in patients in Germany with type 2 diabetes, nephropathy and hypertension].
    Deutsche medizinische Wochenschrift (1946), 2004, Jan-02, Volume: 129, Issue:1-2

    Topics: Amlodipine; Antihypertensive Agents; Biphenyl Compounds; Computer Simulation; Creatinine; Diabetes M

2004
Economic evaluation of the use of irbesartan and amlodipine in the treatment of diabetic nephropathy in patients with hypertension in Canada.
    The Canadian journal of cardiology, 2004, Volume: 20, Issue:1

    Topics: Adult; Aged; Amlodipine; Biphenyl Compounds; Cohort Studies; Cost-Benefit Analysis; Diabetic Nephrop

2004
Early blood pressure normalization independent of the class of antihypertensive agent prevents augmented renal fibronectin and albuminuria in experimental diabetic nephropathy.
    Kidney & blood pressure research, 2004, Volume: 27, Issue:2

    Topics: Albuminuria; Amlodipine; Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weigh

2004
Calcium channel blockers, either amlodipine or mibefradil, ameliorate renal injury in experimental diabetes.
    Kidney international, 2004, Volume: 66, Issue:3

    Topics: Albuminuria; Amlodipine; Animals; Azo Compounds; Blood Pressure; Calcium Channel Blockers; Collagen

2004
[Type 2 diabetic patient with kidney damage. Sartans banish dialysis risk].
    MMW Fortschritte der Medizin, 2004, Jul-08, Volume: 146, Issue:27-28

    Topics: Albuminuria; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Calcium Channel Blockers; Diabetes

2004
[Health economic consequences of the use of irbesartan in patients with type 2 diabetes, hypertension and nephropathy in Switzerland].
    Praxis, 2006, Mar-15, Volume: 95, Issue:11

    Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Biphenyl Compounds; Ca

2006
Differing effects of antihypertensive drugs on the incidence of diabetes mellitus among patients with hypertensive kidney disease.
    Archives of internal medicine, 2006, Apr-10, Volume: 166, Issue:7

    Topics: Adrenergic beta-Antagonists; Adult; Amlodipine; Antihypertensive Agents; Black or African American;

2006
What blood-pressure level provides greatest renoprotection in patients with diabetic nephropathy and hypertension?
    Nature clinical practice. Nephrology, 2006, Volume: 2, Issue:5

    Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Biphenyl Compounds; Di

2006
[Hypertension therapy for type 2 diabetics].
    MMW Fortschritte der Medizin, 2007, Jun-07, Volume: 149, Issue:23

    Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antih

2007
[Risk oriented therapy of hypertension. Lowering blood pressure and risk].
    MMW Fortschritte der Medizin, 2007, Nov-15, Volume: 149, Issue:46

    Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Cardio

2007
[Diabetic patient with hypertension takes A-I I blocker. Less likely dialysis].
    MMW Fortschritte der Medizin, 2002, Feb-21, Volume: 144, Issue:8

    Topics: Albuminuria; Amlodipine; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents;

2002
Role of intrarenal angiotensin-converting enzyme in nephropathy of type II diabetic rats.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2002, Volume: 25, Issue:2

    Topics: Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressu

2002