amlodipine has been researched along with Cold Fingers, Hereditary in 7 studies
Amlodipine: A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
amlodipine : A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 35-year-old woman with a history of breast cancer, treated 3 years ago with surgery, radiation, and chemotherapy presented with a rapid onset of severe Raynaud's phenomenon." | 1.36 | Paraneoplastic Raynaud's phenomenon in a breast cancer survivor. ( Allen, D; Mittoo, S; Robinson, D, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, EY | 1 |
| Park, JK | 1 |
| Lee, W | 1 |
| Kim, YK | 1 |
| Park, CS | 1 |
| Giles, JT | 1 |
| Park, JW | 1 |
| Shin, K | 1 |
| Lee, JS | 1 |
| Song, YW | 1 |
| Lee, EB | 1 |
| Allen, D | 1 |
| Robinson, D | 1 |
| Mittoo, S | 1 |
| Korkmaz, S | 1 |
| Işik, U | 1 |
| Korkmaz, H | 1 |
| Pope, J | 1 |
| White, WB | 1 |
| Parke, AL | 1 |
| La Civita, L | 1 |
| Pitaro, N | 1 |
| Rossi, M | 1 |
| Gambini, I | 1 |
| Giuggioli, D | 1 |
| Cini, G | 1 |
| Ferri, C | 1 |
| Sturgill, MG | 1 |
| Seibold, JR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Phosphodiesterase-5 Inhibitor and Calcium Channel Inhibitor for the Treatment of Secondary Raynaud Phenomenon, Double Blind, Randomized, Cross-over Trial[NCT01280266] | Phase 2/Phase 3 | 29 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| A Randomized, Placebo-controlled Trial of St.John's Wort(a Natural Health Product) in the Treatment on Raynaud's Phenomenon[NCT00351117] | Phase 3 | 20 participants (Actual) | Interventional | 2007-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
0 - unlimited. Number of digital ulcers in all fingers are counted by the investigators and recorded at each visit. The number of ulcers in all fingers indirectly reflect the extent of critical ischemia. As such. the decrease in digital ulcer number reflects positive response to treatment (=better blood flow), whereas the increase ulcer numbers indicates worsening finger ischemia from baseline. (NCT01280266)
Timeframe: baseline and 4 weeks
| Intervention | Digital ulcers (Mean) |
|---|---|
| Amlodipine | 0.1 |
| Udenafil | 0.1 |
Ordinal scale 0-10 0 good 10 bad (NCT01280266)
Timeframe: 0 and 4 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Amlodipine | 0.1 |
| Udenafil | -0.1 |
"Change in digital artery flow velocity in proper palmar digital artery in cm/sec.~0-unlimited" (NCT01280266)
Timeframe: baseline and 4 weeks
| Intervention | cm/sec (Mean) |
|---|---|
| Amlodipine | -19.9 |
| Udenafil | 63.2 |
"Physician's global assessment (PGA) on VAS assesses the overall condition of the patient. The scale ranges from 0 - 10, with 0 being good and 10 bad. As such, change in the GPA measures the change in the patient's condition from the baseline.~negative value (decrease in value) means improvement." (NCT01280266)
Timeframe: at 0 (baseline) and 4 weeks (after treatment)
| Intervention | units on a scale (Mean) |
|---|---|
| Amlodipine | -0.9 |
| Udenafil | -1.5 |
"change in the RCS. RCS combines daily activty, frequency, duration and severity as well as impact of RP attack (Measuring disease activity and functional status in patients with scleroderma and Raynaud's phenomenon, Merkel et al,Arthritis Rheum. 2002 Sep;46(9):2410-20).~Range 0-10 ordinal scale 0..good 10.. bad" (NCT01280266)
Timeframe: baseline and 4 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Amlodipine | -0.5 |
| Udenafil | -0.3 |
Change in the average RP duration in minutes (min) per attack. 0 -- unlimited (NCT01280266)
Timeframe: baseline and 4 weeks
| Intervention | min per attack (Mean) |
|---|---|
| Amlodipine | -1.1 |
| Udenafil | -1.4 |
The temperature difference between finger tips and dorsum of same hand. range 0 - unlimited in degree celcius. (NCT01280266)
Timeframe: baseline and 4 weeks
| Intervention | degree celcius. (Mean) |
|---|---|
| Amlodipine | -0.7 |
| Udenafil | -1.4 |
Change in RP frequency after amlodipine and udenafil number of RP attack per day 0 -- unlimited. (NCT01280266)
Timeframe: baselin and 4 weeks
| Intervention | attacks per day (Mean) |
|---|---|
| Amlodipine | -0.5 |
| Udenafil | -0.5 |
changes in the averaged blood flow (Time-averaged peak velocity) Blood flow in cm/sec 0 - unlimited. (NCT01280266)
Timeframe: baseline and 4 weeks
| Intervention | cm/sec (Mean) |
|---|---|
| Amlodipine | -17.3 |
| Udenafil | 33.4 |
1 review available for amlodipine and Cold Fingers, Hereditary
| Article | Year |
|---|---|
Raynaud's phenomenon (primary).
Topics: Amlodipine; Diltiazem; Humans; Nafronyl; Nicardipine; Nifedipine; Raynaud Disease; Vasodilator Agent | 2003 |
2 trials available for amlodipine and Cold Fingers, Hereditary
| Article | Year |
|---|---|
Head-to-head comparison of udenafil vs amlodipine in the treatment of secondary Raynaud's phenomenon: a double-blind, randomized, cross-over study.
Topics: Adult; Amlodipine; Connective Tissue Diseases; Cross-Over Studies; Double-Blind Method; Female; Fing | 2014 |
Amlodipine in the treatment of Raynaud's phenomenon.
Topics: Adult; Amlodipine; Double-Blind Method; Female; Humans; Male; Middle Aged; Raynaud Disease; Treatmen | 1993 |
4 other studies available for amlodipine and Cold Fingers, Hereditary
| Article | Year |
|---|---|
Paraneoplastic Raynaud's phenomenon in a breast cancer survivor.
Topics: Adult; Amlodipine; Antibodies, Antinuclear; Antineoplastic Agents; Breast Neoplasms; Edema; Female; | 2010 |
Raynaud’s phenomenon in a patient with schizophrenia and obsessive-compulsive disorder: a case report.
Topics: Amlodipine; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Benzodiazepines; Clonaze | 2011 |
Acute pain in the tip of the index finger.
Topics: Acute Disease; Amlodipine; Arterial Occlusive Diseases; Aspirin; Cyanosis; Diagnostic Errors; Female | 2005 |
Rational use of calcium-channel antagonists in Raynaud's phenomenon.
Topics: Amlodipine; Calcium Channel Blockers; Diltiazem; Felodipine; Humans; Isradipine; Nicardipine; Nifedi | 1998 |