amlodipine has been researched along with Cardiomegaly in 23 studies
Amlodipine: A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
amlodipine : A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study aims to study the role of receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B/osteoprotegerin (RANKL/RANK/OPG) system in cardiac hypertrophy in a spontaneous hypertension rat (SHR) model and the effects of amlodipine and atorvastatin intervention." | 7.83 | Amlodipine and atorvastatin improved hypertensive cardiac hypertrophy through regulation of receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B/osteoprotegerin system in spontaneous hypertension rats. ( Cui, W; Du, H; Hao, J; Liu, D; Liu, F; Lu, J; Yang, X, 2016) |
| "Hypercholesterolemia is a common accompaniment of atherosclerosis and may be associated with cardiac hypertrophy." | 5.35 | Cardiac hypertrophy during hypercholesterolemia and its amelioration with rosuvastatin and amlodipine. ( Kang, BY; Mehta, JL; Palade, P; Sharma, SG; Wang, W, 2009) |
| "Amlodipine orotate was prepared by reacting orotic acid and amlodipine to increase the dissolution rate at higher gastric pH conditions." | 5.33 | Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats. ( Ahn, BO; Choi, SM; Kim, JE; Kwon, JW, 2006) |
| "Body weight was measured weekly in all the groups, and arterial blood pressure was also measured in all the 10-, 15-, 20-, and 25-week-old SHR by the tail cuff method." | 5.32 | Effect of dietary calcium supplements and amlodipine on growth, arterial blood pressure, and cardiac hypertrophy of spontaneously hypertensive rats. ( Aleixandre, A; Civantos, B, 2003) |
| "Amlodipine is a long-acting dihydropyridine-based calcium antagonist developed for use on a once-a-day basis." | 5.27 | The effect of amlodipine on hypertension-induced cardiac hypertrophy and reperfusion-induced calcium overload. ( Nayler, WG, 1988) |
| "The present study aims to study the role of receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B/osteoprotegerin (RANKL/RANK/OPG) system in cardiac hypertrophy in a spontaneous hypertension rat (SHR) model and the effects of amlodipine and atorvastatin intervention." | 3.83 | Amlodipine and atorvastatin improved hypertensive cardiac hypertrophy through regulation of receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B/osteoprotegerin system in spontaneous hypertension rats. ( Cui, W; Du, H; Hao, J; Liu, D; Liu, F; Lu, J; Yang, X, 2016) |
| "Azelnidipine suppressed cardiac hypertrophy, fibrosis, NADPH oxidase and superoxide in spSHRs more potently than amlodipine, and was associated with lower heart rates than amlodipine." | 3.73 | Enhancement of cardiac oxidative stress by tachycardia and its critical role in cardiac hypertrophy and fibrosis. ( Ito, T; Kataoka, K; Kim-Mitsuyama, S; Lai, ZF; Ogawa, H; Tanaka, T; Tokutomi, Y; Yamamoto, E; Yamashita, T, 2006) |
| "The effects of amlodipine on blood pressure profiles, cardiac hypertrophy, and beta-adrenergic signal transduction were studied in transgenic hypertensive TGR(mREN2)27 rats (TGRs), which are characterized by an inverse circadian blood pressure rhythm." | 3.70 | Effects of amlodipine once or twice daily on circadian blood pressure profile, myocardial hypertrophy, and beta-adrenergic signaling in transgenic hypertensive TGR(mREN2)27 rats. ( Lemmer, B; Schmidt, T; Schnecko, A; Voll, C; Witte, K, 1998) |
| "Hypercholesterolemia is a common accompaniment of atherosclerosis and may be associated with cardiac hypertrophy." | 1.35 | Cardiac hypertrophy during hypercholesterolemia and its amelioration with rosuvastatin and amlodipine. ( Kang, BY; Mehta, JL; Palade, P; Sharma, SG; Wang, W, 2009) |
| "Amlodipine orotate was prepared by reacting orotic acid and amlodipine to increase the dissolution rate at higher gastric pH conditions." | 1.33 | Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats. ( Ahn, BO; Choi, SM; Kim, JE; Kwon, JW, 2006) |
| "Both rapamycin and PD98059 attenuated cardiac hypertrophy in this model." | 1.32 | Long-acting Ca2+ blockers prevent myocardial remodeling induced by chronic NO inhibition in rats. ( Asakura, M; Asanuma, H; Hori, M; Kim, J; Kitakaze, M; Liao, Y; Minamino, T; Node, K; Ogai, A; Ogita, H; Sanada, S; Takashima, S, 2003) |
| "Body weight was measured weekly in all the groups, and arterial blood pressure was also measured in all the 10-, 15-, 20-, and 25-week-old SHR by the tail cuff method." | 1.32 | Effect of dietary calcium supplements and amlodipine on growth, arterial blood pressure, and cardiac hypertrophy of spontaneously hypertensive rats. ( Aleixandre, A; Civantos, B, 2003) |
| "Hypertension is a complex disease, the treatment of which should not only lower systolic and diastolic blood pressure but also attenuate the secondary consequences of the disease." | 1.29 | End-organ involvement and calcium antagonist therapy: animal studies. ( Nayler, WG, 1994) |
| "Concomitantly, cardiac hypertrophy was attenuated in the treated group compared with the placebo group (heart-to-body weight ratios of 4." | 1.28 | Vascular injury: mechanisms and manifestations. ( Nayler, WG, 1991) |
| "Amlodipine is a long-acting dihydropyridine calcium antagonist with vascular selectivity." | 1.28 | Vascular and myocardial effects of amlodipine: an overview. ( Gu, XH; Nayler, WG, 1991) |
| "Amlodipine is a long-acting dihydropyridine-based calcium antagonist developed for use on a once-a-day basis." | 1.27 | The effect of amlodipine on hypertension-induced cardiac hypertrophy and reperfusion-induced calcium overload. ( Nayler, WG, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 7 (30.43) | 18.2507 |
| 2000's | 12 (52.17) | 29.6817 |
| 2010's | 3 (13.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, J | 2 |
| Liu, F | 3 |
| Liu, D | 2 |
| Du, H | 1 |
| Hao, J | 1 |
| Yang, X | 1 |
| Cui, W | 3 |
| Chen, F | 1 |
| Jin, Y | 1 |
| Chen, H | 1 |
| Choi, SM | 2 |
| Seo, MJ | 1 |
| Kang, KK | 1 |
| Kim, JH | 1 |
| Ahn, BO | 2 |
| Yoo, M | 1 |
| Lu, JC | 1 |
| Zhang, HL | 1 |
| Han, M | 1 |
| Liu, DM | 1 |
| Yin, HN | 1 |
| Zhang, K | 1 |
| Du, J | 1 |
| Kang, BY | 1 |
| Wang, W | 1 |
| Palade, P | 1 |
| Sharma, SG | 1 |
| Mehta, JL | 1 |
| Takahara, A | 1 |
| Nakamura, Y | 1 |
| Wagatsuma, H | 1 |
| Aritomi, S | 1 |
| Nakayama, A | 1 |
| Satoh, Y | 1 |
| Akie, Y | 1 |
| Sugiyama, A | 1 |
| Dong, J | 1 |
| Chen, X | 1 |
| So, Y | 1 |
| Xin, H | 1 |
| Jiang, W | 1 |
| Jiang, L | 1 |
| Luo, Q | 1 |
| Xuan, WL | 1 |
| Xi, F | 1 |
| Liao, YL | 1 |
| Kitakaze, M | 3 |
| Sanada, S | 1 |
| Node, K | 1 |
| Minamino, T | 2 |
| Takashima, S | 2 |
| Ogai, A | 1 |
| Asanuma, H | 1 |
| Ogita, H | 1 |
| Liao, Y | 2 |
| Asakura, M | 2 |
| Kim, J | 1 |
| Hori, M | 2 |
| Civantos, B | 1 |
| Aleixandre, A | 1 |
| Kato, H | 1 |
| Asano, Y | 1 |
| Shintani, Y | 1 |
| Tomoike, H | 1 |
| Kim, JE | 1 |
| Kwon, JW | 1 |
| Iwashima, Y | 1 |
| Okada, M | 1 |
| Haneda, M | 1 |
| Yoshida, T | 1 |
| Yamamoto, E | 1 |
| Lai, ZF | 1 |
| Yamashita, T | 1 |
| Tanaka, T | 1 |
| Kataoka, K | 1 |
| Tokutomi, Y | 1 |
| Ito, T | 1 |
| Ogawa, H | 1 |
| Kim-Mitsuyama, S | 1 |
| Nayler, WG | 4 |
| Agabiti-Rosei, E | 1 |
| Muiesan, ML | 1 |
| Rizzoni, D | 1 |
| Zulli, R | 1 |
| Calebich, S | 1 |
| Castellano, M | 1 |
| Cavaliere, G | 1 |
| Nordio, G | 1 |
| Pasini, F | 1 |
| Zuccato, F | 1 |
| Patel, VB | 1 |
| Siddiq, T | 1 |
| Richardson, PJ | 1 |
| Marway, JS | 1 |
| Paice, AG | 1 |
| Preedy, VR | 1 |
| Yamazaki, T | 1 |
| Komuro, I | 1 |
| Zou, Y | 1 |
| Kudoh, S | 1 |
| Shiojima, I | 1 |
| Mizuno, T | 1 |
| Hiroi, Y | 1 |
| Nagai, R | 1 |
| Yazaki, Y | 1 |
| Witte, K | 1 |
| Schnecko, A | 1 |
| Voll, C | 1 |
| Schmidt, T | 1 |
| Lemmer, B | 1 |
| Uusimaa, P | 1 |
| Tokola, H | 1 |
| Ruskoaho, H | 1 |
| Vuolteenaho, O | 1 |
| Risteli, J | 1 |
| Ylitalo, A | 1 |
| Peuhkurinen, K | 1 |
| Gu, XH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Blood Pressure Lowering Effects of Amosartan Regarding Proviso in Patients With Hypertension: Prospective, Multicenter, Observational Study[NCT03255551] | 50 participants (Actual) | Observational | 2014-01-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for amlodipine and Cardiomegaly
| Article | Year |
|---|---|
Regression of cardiac hypertrophy in type 2 diabetes with hypertension by candesartan.
Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure | 2006 |
Cardiovascular structural changes and calcium antagonist therapy in patients with hypertension.
Topics: Adult; Amlodipine; Analysis of Variance; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Card | 1994 |
21 other studies available for amlodipine and Cardiomegaly
| Article | Year |
|---|---|
Amlodipine and atorvastatin improved hypertensive cardiac hypertrophy through regulation of receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B/osteoprotegerin system in spontaneous hypertension rats.
Topics: Administration, Oral; Amlodipine; Animals; Antihypertensive Agents; Atorvastatin; Cardiomegaly; Cros | 2016 |
Amlodipine and atorvastatin improve ventricular hypertrophy and diastolic function via inhibiting TNF-α, IL-1β and NF-κB inflammatory cytokine networks in elderly spontaneously hypertensive rats.
Topics: Aging; Amlodipine; Animals; Atorvastatin; C-Reactive Protein; Cardiomegaly; Diastole; Heart Ventricl | 2016 |
Beneficial effects of the combination of amlodipine and losartan for lowering blood pressure in spontaneously hypertensive rats.
Topics: Acetylcholine; Administration, Oral; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Animals; A | 2009 |
Additive beneficial effects of amlodipine and atorvastatin in reversing advanced cardiac hypertrophy in elderly spontaneously hypertensive rats.
Topics: Aging; Amlodipine; Animals; Anticholesteremic Agents; Antihypertensive Agents; Atorvastatin; Cardiom | 2009 |
Cardiac hypertrophy during hypercholesterolemia and its amelioration with rosuvastatin and amlodipine.
Topics: Amlodipine; Animals; Blood Pressure; Body Weight; Calcium Channel Blockers; Cardiomegaly; Cholestero | 2009 |
Long-term blockade of L/N-type Ca(2+) channels by cilnidipine ameliorates repolarization abnormality of the canine hypertrophied heart.
Topics: Action Potentials; Amlodipine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Atr | 2009 |
[Intermedin (IMD) gene expression in hypertrophic cardiac myocyte of renal vascular hypertension rats and the intervention of Valsartan, Amlodipine and Enalapril in the expression].
Topics: Adrenomedullin; Amlodipine; Animals; Antihypertensive Agents; Cardiomegaly; Enalapril; Hypertension, | 2009 |
[Antihypertrophic effect of dihydropyridines calcium channel blockers is dependent on their potential of blocking N-type calcium channel].
Topics: Amlodipine; Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Cardiomegaly; Dihydropyridi | 2010 |
Long-acting Ca2+ blockers prevent myocardial remodeling induced by chronic NO inhibition in rats.
Topics: Amlodipine; Animals; Blood Pressure; Calcium Channel Blockers; Cardiomegaly; Dihydropyridines; Enzym | 2003 |
Effect of dietary calcium supplements and amlodipine on growth, arterial blood pressure, and cardiac hypertrophy of spontaneously hypertensive rats.
Topics: Amlodipine; Animals; Blood Pressure; Body Weight; Calcium Channel Blockers; Calcium, Dietary; Cardio | 2003 |
Amlodipine ameliorates myocardial hypertrophy by inhibiting EGFR phosphorylation.
Topics: Amlodipine; Animals; Cardiomegaly; Cells, Cultured; Epidermal Growth Factor; Epinephrine; ErbB Recep | 2005 |
Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats.
Topics: Amlodipine; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Calcium; Cardiomegaly; Ce | 2006 |
Enhancement of cardiac oxidative stress by tachycardia and its critical role in cardiac hypertrophy and fibrosis.
Topics: Amlodipine; Animals; Azetidinecarboxylic Acid; Cardiomegaly; Dihydropyridines; Endomyocardial Fibros | 2006 |
End-organ involvement and calcium antagonist therapy: animal studies.
Topics: Administration, Oral; Amlodipine; Animals; Aorta, Thoracic; Arteriosclerosis; Binding Sites; Blood P | 1994 |
The regression of chronic hypertrophy by a calcium channel antagonist and an ACE-inhibitor.
Topics: Amlodipine; Animals; Blood Pressure; Cardiomegaly; Chronic Disease; Lisinopril; Male; Muscle Protein | 1994 |
Efficient inhibition of the development of cardiac remodeling by a long-acting calcium antagonist amlodipine.
Topics: Amlodipine; Animals; Antihypertensive Agents; Calcium Channel Blockers; Cardiomegaly; Collagen; Hear | 1998 |
Effects of amlodipine once or twice daily on circadian blood pressure profile, myocardial hypertrophy, and beta-adrenergic signaling in transgenic hypertensive TGR(mREN2)27 rats.
Topics: Adenylyl Cyclases; Amlodipine; Animals; Animals, Genetically Modified; Antihypertensive Agents; Bloo | 1998 |
Vasoactive peptides and procollagen propeptides in patients with hypertension in relation to cardiac hypertrophy and diastolic heart failure: design of the study and patient characteristics.
Topics: Amlodipine; Antihypertensive Agents; Atenolol; Atrial Natriuretic Factor; Bendroflumethiazide; Cardi | 2001 |
Vascular injury: mechanisms and manifestations.
Topics: Amlodipine; Animals; Aorta, Thoracic; Arteriosclerosis; Calcium; Calcium Channel Blockers; Cardiomeg | 1991 |
Vascular and myocardial effects of amlodipine: an overview.
Topics: Amlodipine; Animals; Arteriosclerosis; Binding Sites; Calcium Channel Blockers; Cardiomegaly; Cerebr | 1991 |
The effect of amlodipine on hypertension-induced cardiac hypertrophy and reperfusion-induced calcium overload.
Topics: Aging; Amlodipine; Animals; Blood Pressure; Calcium; Calcium Channel Blockers; Cardiomegaly; Coronar | 1988 |