amlodipine has been researched along with Cardiac Hypertrophy in 23 studies
Amlodipine: A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
amlodipine : A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study aims to study the role of receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B/osteoprotegerin (RANKL/RANK/OPG) system in cardiac hypertrophy in a spontaneous hypertension rat (SHR) model and the effects of amlodipine and atorvastatin intervention." | 7.83 | Amlodipine and atorvastatin improved hypertensive cardiac hypertrophy through regulation of receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B/osteoprotegerin system in spontaneous hypertension rats. ( Cui, W; Du, H; Hao, J; Liu, D; Liu, F; Lu, J; Yang, X, 2016) |
| "Hypercholesterolemia is a common accompaniment of atherosclerosis and may be associated with cardiac hypertrophy." | 5.35 | Cardiac hypertrophy during hypercholesterolemia and its amelioration with rosuvastatin and amlodipine. ( Kang, BY; Mehta, JL; Palade, P; Sharma, SG; Wang, W, 2009) |
| "Amlodipine orotate was prepared by reacting orotic acid and amlodipine to increase the dissolution rate at higher gastric pH conditions." | 5.33 | Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats. ( Ahn, BO; Choi, SM; Kim, JE; Kwon, JW, 2006) |
| "Body weight was measured weekly in all the groups, and arterial blood pressure was also measured in all the 10-, 15-, 20-, and 25-week-old SHR by the tail cuff method." | 5.32 | Effect of dietary calcium supplements and amlodipine on growth, arterial blood pressure, and cardiac hypertrophy of spontaneously hypertensive rats. ( Aleixandre, A; Civantos, B, 2003) |
| "Amlodipine is a long-acting dihydropyridine-based calcium antagonist developed for use on a once-a-day basis." | 5.27 | The effect of amlodipine on hypertension-induced cardiac hypertrophy and reperfusion-induced calcium overload. ( Nayler, WG, 1988) |
| "The present study aims to study the role of receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B/osteoprotegerin (RANKL/RANK/OPG) system in cardiac hypertrophy in a spontaneous hypertension rat (SHR) model and the effects of amlodipine and atorvastatin intervention." | 3.83 | Amlodipine and atorvastatin improved hypertensive cardiac hypertrophy through regulation of receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B/osteoprotegerin system in spontaneous hypertension rats. ( Cui, W; Du, H; Hao, J; Liu, D; Liu, F; Lu, J; Yang, X, 2016) |
| "Azelnidipine suppressed cardiac hypertrophy, fibrosis, NADPH oxidase and superoxide in spSHRs more potently than amlodipine, and was associated with lower heart rates than amlodipine." | 3.73 | Enhancement of cardiac oxidative stress by tachycardia and its critical role in cardiac hypertrophy and fibrosis. ( Ito, T; Kataoka, K; Kim-Mitsuyama, S; Lai, ZF; Ogawa, H; Tanaka, T; Tokutomi, Y; Yamamoto, E; Yamashita, T, 2006) |
| "The effects of amlodipine on blood pressure profiles, cardiac hypertrophy, and beta-adrenergic signal transduction were studied in transgenic hypertensive TGR(mREN2)27 rats (TGRs), which are characterized by an inverse circadian blood pressure rhythm." | 3.70 | Effects of amlodipine once or twice daily on circadian blood pressure profile, myocardial hypertrophy, and beta-adrenergic signaling in transgenic hypertensive TGR(mREN2)27 rats. ( Lemmer, B; Schmidt, T; Schnecko, A; Voll, C; Witte, K, 1998) |
| "Hypercholesterolemia is a common accompaniment of atherosclerosis and may be associated with cardiac hypertrophy." | 1.35 | Cardiac hypertrophy during hypercholesterolemia and its amelioration with rosuvastatin and amlodipine. ( Kang, BY; Mehta, JL; Palade, P; Sharma, SG; Wang, W, 2009) |
| "Amlodipine orotate was prepared by reacting orotic acid and amlodipine to increase the dissolution rate at higher gastric pH conditions." | 1.33 | Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats. ( Ahn, BO; Choi, SM; Kim, JE; Kwon, JW, 2006) |
| "Both rapamycin and PD98059 attenuated cardiac hypertrophy in this model." | 1.32 | Long-acting Ca2+ blockers prevent myocardial remodeling induced by chronic NO inhibition in rats. ( Asakura, M; Asanuma, H; Hori, M; Kim, J; Kitakaze, M; Liao, Y; Minamino, T; Node, K; Ogai, A; Ogita, H; Sanada, S; Takashima, S, 2003) |
| "Body weight was measured weekly in all the groups, and arterial blood pressure was also measured in all the 10-, 15-, 20-, and 25-week-old SHR by the tail cuff method." | 1.32 | Effect of dietary calcium supplements and amlodipine on growth, arterial blood pressure, and cardiac hypertrophy of spontaneously hypertensive rats. ( Aleixandre, A; Civantos, B, 2003) |
| "Hypertension is a complex disease, the treatment of which should not only lower systolic and diastolic blood pressure but also attenuate the secondary consequences of the disease." | 1.29 | End-organ involvement and calcium antagonist therapy: animal studies. ( Nayler, WG, 1994) |
| "Concomitantly, cardiac hypertrophy was attenuated in the treated group compared with the placebo group (heart-to-body weight ratios of 4." | 1.28 | Vascular injury: mechanisms and manifestations. ( Nayler, WG, 1991) |
| "Amlodipine is a long-acting dihydropyridine calcium antagonist with vascular selectivity." | 1.28 | Vascular and myocardial effects of amlodipine: an overview. ( Gu, XH; Nayler, WG, 1991) |
| "Amlodipine is a long-acting dihydropyridine-based calcium antagonist developed for use on a once-a-day basis." | 1.27 | The effect of amlodipine on hypertension-induced cardiac hypertrophy and reperfusion-induced calcium overload. ( Nayler, WG, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 7 (30.43) | 18.2507 |
| 2000's | 12 (52.17) | 29.6817 |
| 2010's | 3 (13.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, J | 2 |
| Liu, F | 3 |
| Liu, D | 2 |
| Du, H | 1 |
| Hao, J | 1 |
| Yang, X | 1 |
| Cui, W | 3 |
| Chen, F | 1 |
| Jin, Y | 1 |
| Chen, H | 1 |
| Choi, SM | 2 |
| Seo, MJ | 1 |
| Kang, KK | 1 |
| Kim, JH | 1 |
| Ahn, BO | 2 |
| Yoo, M | 1 |
| Lu, JC | 1 |
| Zhang, HL | 1 |
| Han, M | 1 |
| Liu, DM | 1 |
| Yin, HN | 1 |
| Zhang, K | 1 |
| Du, J | 1 |
| Kang, BY | 1 |
| Wang, W | 1 |
| Palade, P | 1 |
| Sharma, SG | 1 |
| Mehta, JL | 1 |
| Takahara, A | 1 |
| Nakamura, Y | 1 |
| Wagatsuma, H | 1 |
| Aritomi, S | 1 |
| Nakayama, A | 1 |
| Satoh, Y | 1 |
| Akie, Y | 1 |
| Sugiyama, A | 1 |
| Dong, J | 1 |
| Chen, X | 1 |
| So, Y | 1 |
| Xin, H | 1 |
| Jiang, W | 1 |
| Jiang, L | 1 |
| Luo, Q | 1 |
| Xuan, WL | 1 |
| Xi, F | 1 |
| Liao, YL | 1 |
| Kitakaze, M | 3 |
| Sanada, S | 1 |
| Node, K | 1 |
| Minamino, T | 2 |
| Takashima, S | 2 |
| Ogai, A | 1 |
| Asanuma, H | 1 |
| Ogita, H | 1 |
| Liao, Y | 2 |
| Asakura, M | 2 |
| Kim, J | 1 |
| Hori, M | 2 |
| Civantos, B | 1 |
| Aleixandre, A | 1 |
| Kato, H | 1 |
| Asano, Y | 1 |
| Shintani, Y | 1 |
| Tomoike, H | 1 |
| Kim, JE | 1 |
| Kwon, JW | 1 |
| Iwashima, Y | 1 |
| Okada, M | 1 |
| Haneda, M | 1 |
| Yoshida, T | 1 |
| Yamamoto, E | 1 |
| Lai, ZF | 1 |
| Yamashita, T | 1 |
| Tanaka, T | 1 |
| Kataoka, K | 1 |
| Tokutomi, Y | 1 |
| Ito, T | 1 |
| Ogawa, H | 1 |
| Kim-Mitsuyama, S | 1 |
| Nayler, WG | 4 |
| Agabiti-Rosei, E | 1 |
| Muiesan, ML | 1 |
| Rizzoni, D | 1 |
| Zulli, R | 1 |
| Calebich, S | 1 |
| Castellano, M | 1 |
| Cavaliere, G | 1 |
| Nordio, G | 1 |
| Pasini, F | 1 |
| Zuccato, F | 1 |
| Patel, VB | 1 |
| Siddiq, T | 1 |
| Richardson, PJ | 1 |
| Marway, JS | 1 |
| Paice, AG | 1 |
| Preedy, VR | 1 |
| Yamazaki, T | 1 |
| Komuro, I | 1 |
| Zou, Y | 1 |
| Kudoh, S | 1 |
| Shiojima, I | 1 |
| Mizuno, T | 1 |
| Hiroi, Y | 1 |
| Nagai, R | 1 |
| Yazaki, Y | 1 |
| Witte, K | 1 |
| Schnecko, A | 1 |
| Voll, C | 1 |
| Schmidt, T | 1 |
| Lemmer, B | 1 |
| Uusimaa, P | 1 |
| Tokola, H | 1 |
| Ruskoaho, H | 1 |
| Vuolteenaho, O | 1 |
| Risteli, J | 1 |
| Ylitalo, A | 1 |
| Peuhkurinen, K | 1 |
| Gu, XH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Blood Pressure Lowering Effects of Amosartan Regarding Proviso in Patients With Hypertension: Prospective, Multicenter, Observational Study[NCT03255551] | 50 participants (Actual) | Observational | 2014-01-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for amlodipine and Cardiac Hypertrophy
| Article | Year |
|---|---|
Regression of cardiac hypertrophy in type 2 diabetes with hypertension by candesartan.
Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure | 2006 |
Cardiovascular structural changes and calcium antagonist therapy in patients with hypertension.
Topics: Adult; Amlodipine; Analysis of Variance; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Card | 1994 |
21 other studies available for amlodipine and Cardiac Hypertrophy
| Article | Year |
|---|---|
Amlodipine and atorvastatin improved hypertensive cardiac hypertrophy through regulation of receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B/osteoprotegerin system in spontaneous hypertension rats.
Topics: Administration, Oral; Amlodipine; Animals; Antihypertensive Agents; Atorvastatin; Cardiomegaly; Cros | 2016 |
Amlodipine and atorvastatin improve ventricular hypertrophy and diastolic function via inhibiting TNF-α, IL-1β and NF-κB inflammatory cytokine networks in elderly spontaneously hypertensive rats.
Topics: Aging; Amlodipine; Animals; Atorvastatin; C-Reactive Protein; Cardiomegaly; Diastole; Heart Ventricl | 2016 |
Beneficial effects of the combination of amlodipine and losartan for lowering blood pressure in spontaneously hypertensive rats.
Topics: Acetylcholine; Administration, Oral; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Animals; A | 2009 |
Additive beneficial effects of amlodipine and atorvastatin in reversing advanced cardiac hypertrophy in elderly spontaneously hypertensive rats.
Topics: Aging; Amlodipine; Animals; Anticholesteremic Agents; Antihypertensive Agents; Atorvastatin; Cardiom | 2009 |
Cardiac hypertrophy during hypercholesterolemia and its amelioration with rosuvastatin and amlodipine.
Topics: Amlodipine; Animals; Blood Pressure; Body Weight; Calcium Channel Blockers; Cardiomegaly; Cholestero | 2009 |
Long-term blockade of L/N-type Ca(2+) channels by cilnidipine ameliorates repolarization abnormality of the canine hypertrophied heart.
Topics: Action Potentials; Amlodipine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Atr | 2009 |
[Intermedin (IMD) gene expression in hypertrophic cardiac myocyte of renal vascular hypertension rats and the intervention of Valsartan, Amlodipine and Enalapril in the expression].
Topics: Adrenomedullin; Amlodipine; Animals; Antihypertensive Agents; Cardiomegaly; Enalapril; Hypertension, | 2009 |
[Antihypertrophic effect of dihydropyridines calcium channel blockers is dependent on their potential of blocking N-type calcium channel].
Topics: Amlodipine; Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Cardiomegaly; Dihydropyridi | 2010 |
Long-acting Ca2+ blockers prevent myocardial remodeling induced by chronic NO inhibition in rats.
Topics: Amlodipine; Animals; Blood Pressure; Calcium Channel Blockers; Cardiomegaly; Dihydropyridines; Enzym | 2003 |
Effect of dietary calcium supplements and amlodipine on growth, arterial blood pressure, and cardiac hypertrophy of spontaneously hypertensive rats.
Topics: Amlodipine; Animals; Blood Pressure; Body Weight; Calcium Channel Blockers; Calcium, Dietary; Cardio | 2003 |
Amlodipine ameliorates myocardial hypertrophy by inhibiting EGFR phosphorylation.
Topics: Amlodipine; Animals; Cardiomegaly; Cells, Cultured; Epidermal Growth Factor; Epinephrine; ErbB Recep | 2005 |
Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats.
Topics: Amlodipine; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Calcium; Cardiomegaly; Ce | 2006 |
Enhancement of cardiac oxidative stress by tachycardia and its critical role in cardiac hypertrophy and fibrosis.
Topics: Amlodipine; Animals; Azetidinecarboxylic Acid; Cardiomegaly; Dihydropyridines; Endomyocardial Fibros | 2006 |
End-organ involvement and calcium antagonist therapy: animal studies.
Topics: Administration, Oral; Amlodipine; Animals; Aorta, Thoracic; Arteriosclerosis; Binding Sites; Blood P | 1994 |
The regression of chronic hypertrophy by a calcium channel antagonist and an ACE-inhibitor.
Topics: Amlodipine; Animals; Blood Pressure; Cardiomegaly; Chronic Disease; Lisinopril; Male; Muscle Protein | 1994 |
Efficient inhibition of the development of cardiac remodeling by a long-acting calcium antagonist amlodipine.
Topics: Amlodipine; Animals; Antihypertensive Agents; Calcium Channel Blockers; Cardiomegaly; Collagen; Hear | 1998 |
Effects of amlodipine once or twice daily on circadian blood pressure profile, myocardial hypertrophy, and beta-adrenergic signaling in transgenic hypertensive TGR(mREN2)27 rats.
Topics: Adenylyl Cyclases; Amlodipine; Animals; Animals, Genetically Modified; Antihypertensive Agents; Bloo | 1998 |
Vasoactive peptides and procollagen propeptides in patients with hypertension in relation to cardiac hypertrophy and diastolic heart failure: design of the study and patient characteristics.
Topics: Amlodipine; Antihypertensive Agents; Atenolol; Atrial Natriuretic Factor; Bendroflumethiazide; Cardi | 2001 |
Vascular injury: mechanisms and manifestations.
Topics: Amlodipine; Animals; Aorta, Thoracic; Arteriosclerosis; Calcium; Calcium Channel Blockers; Cardiomeg | 1991 |
Vascular and myocardial effects of amlodipine: an overview.
Topics: Amlodipine; Animals; Arteriosclerosis; Binding Sites; Calcium Channel Blockers; Cardiomegaly; Cerebr | 1991 |
The effect of amlodipine on hypertension-induced cardiac hypertrophy and reperfusion-induced calcium overload.
Topics: Aging; Amlodipine; Animals; Blood Pressure; Calcium; Calcium Channel Blockers; Cardiomegaly; Coronar | 1988 |