Page last updated: 2024-10-22

amlodipine and Atrial Fibrillation

amlodipine has been researched along with Atrial Fibrillation in 16 studies

Amlodipine: A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
amlodipine : A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.

Atrial Fibrillation: Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.

Research Excerpts

ExcerptRelevanceReference
"This study compared the effect of antihypertensive treatment with valsartan or ramipril on atrial fibrillation (AF) recurrence, on P-wave dispersion, (PWD) and on serum procollagen type I carboxy terminal peptide (PIP)."9.13Effect of valsartan and ramipril on atrial fibrillation recurrence and P-wave dispersion in hypertensive patients with recurrent symptomatic lone atrial fibrillation. ( Corradi, L; Derosa, G; Ferrari, I; Fogari, R; Lazzari, P; Mugellini, A; Preti, P; Santoro, T; Zoppi, A, 2008)
"The aim of this study was to compare the effect of valsartan/amlodipine and atenolol/amlodipine combination in preventing the recurrence of atrial fibrillation (AF) in hypertensive diabetic patients with a history of recent paroxysmal atrial fibrillation."9.13Comparative evaluation of effect of valsartan/amlodipine and atenolol/amlodipine combinations on atrial fibrillation recurrence in hypertensive patients with type 2 diabetes mellitus. ( Corradi, L; Derosa, G; Fogari, R; Lazzari, P; Mugellini, A; Preti, P; Zoppi, A, 2008)
"The aim of the study was to evaluate the effect of losartan as compared with amlodipine, both associated with amiodarone, in preventing the recurrence of atrial fibrillation (AF) in hypertensive patients with a history of recent paroxysmal atrial fibrillation."9.12Losartan and prevention of atrial fibrillation recurrence in hypertensive patients. ( Corradi, L; Destro, M; Fogari, E; Fogari, R; Mugellini, A; Rinaldi, A; Zoppi, A, 2006)
"Objectives For revealing the peculiarities of the drug-drug interaction of rivaroxaban (substrate CYP3A4 and P-gp) and calcium channel blockers (CCBs) (verapamil - inhibitor CYP3A4 and P-gp and amlodipine - substrate CYP3A4) in patients 80 years and older with nonvalvular atrial fibrillation (NAF) we studied 128 patients."7.96Drug-drug interaction of rivaroxaban and calcium channel blockers in patients aged 80 years and older with nonvalvular atrial fibrillation. ( Bahteeva, D; Bochkov, P; Cherniaeva, M; Golovina, O; Gorbatenkova, S; Kulikova, M; Mirzaev, K; Ostroumova, O; Rytkin, E; Shevchenko, R; Sychev, D, 2020)
"To assess effect of calcium antagonists amlodipine and verapamil on the risk of development of atrial fibrillation after coronary artery bypass surgery."7.72[Effect of calcium antagonists verapamil and amlodipine on the risk of development of atrial fibrillation after coronary artery bypass grafting]. ( Afanas'ev, SA; Akhmedov, ShD; Antonchenko, IV; Dzhavadova, GK; Evtushenko, AV; Kandinskiĭ, ML; Kozlov, BN; Popov, SV; Shipulin, VM; Vecherskiĭ, IuIu, 2003)
"Telmisartan was more effective than amlodipine in preventing AF recurrences in hypertensive patients with paroxysmal AF."6.77Effect of telmisartan on paroxysmal atrial fibrillation recurrence in hypertensive patients with normal or increased left atrial size. ( Derosa, G; Fogari, R; Maffioli, P; Mugellini, A; Perrone, T; Preti, P; Zoppi, A, 2012)
" We sought to determine whether randomization to lisinopril reduces incident AF or atrial flutter (AFL) compared with chlorthalidone in a large clinical trial cohort with extended post-trial surveillance."5.24Pharmacologic Prevention of Incident Atrial Fibrillation: Long-Term Results From the ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial). ( Albert, CM; Alonso, A; Davis, BR; Dewland, TA; Haywood, LJ; Marcus, GM; Simpson, LM; Soliman, EZ; Yamal, JM, 2017)
"The Japanese Rhythm Management Trial II for Atrial Fibrillation (J-RHYTHM II study) is an open-label randomized comparison between an ARB (candesartan) and a CCB (amlodipine) in the treatment of paroxysmal AF associated with hypertension."5.15Randomized trial of angiotensin II-receptor blocker vs. dihydropiridine calcium channel blocker in the treatment of paroxysmal atrial fibrillation with hypertension (J-RHYTHM II study). ( Aizawa, Y; Atarashi, H; Fukatani, M; Hirai, M; Hirayama, A; Inoue, H; Kamakura, S; Kato, T; Kodama, I; Koretsune, Y; Kumagai, K; Kurachi, Y; Mitamura, H; Nakaya, H; Ogawa, S; Ohe, T; Ohtsu, H; Okumura, K; Saikawa, T; Sakurai, M; Sato, T; Sugi, K; Watanabe, E; Yamashita, T; Yamazaki, T, 2011)
"This study compared the effect of antihypertensive treatment with valsartan or ramipril on atrial fibrillation (AF) recurrence, on P-wave dispersion, (PWD) and on serum procollagen type I carboxy terminal peptide (PIP)."5.13Effect of valsartan and ramipril on atrial fibrillation recurrence and P-wave dispersion in hypertensive patients with recurrent symptomatic lone atrial fibrillation. ( Corradi, L; Derosa, G; Ferrari, I; Fogari, R; Lazzari, P; Mugellini, A; Preti, P; Santoro, T; Zoppi, A, 2008)
"The aim of this study was to compare the effect of valsartan/amlodipine and atenolol/amlodipine combination in preventing the recurrence of atrial fibrillation (AF) in hypertensive diabetic patients with a history of recent paroxysmal atrial fibrillation."5.13Comparative evaluation of effect of valsartan/amlodipine and atenolol/amlodipine combinations on atrial fibrillation recurrence in hypertensive patients with type 2 diabetes mellitus. ( Corradi, L; Derosa, G; Fogari, R; Lazzari, P; Mugellini, A; Preti, P; Zoppi, A, 2008)
"The aim of the study was to evaluate the effect of losartan as compared with amlodipine, both associated with amiodarone, in preventing the recurrence of atrial fibrillation (AF) in hypertensive patients with a history of recent paroxysmal atrial fibrillation."5.12Losartan and prevention of atrial fibrillation recurrence in hypertensive patients. ( Corradi, L; Destro, M; Fogari, E; Fogari, R; Mugellini, A; Rinaldi, A; Zoppi, A, 2006)
"The Japanese Rhythm Management Trial II for Atrial Fibrillation (J-RHYTHM II study) is a randomized comparative evaluation of an angiotensin II type 1 blocker (candesartan) and a dihydropiridine calcium blocker (amlodipine), both combined with antithrombotic therapy, as an antiarrhythmic therapy for the treatment of paroxysmal AF (PAF) associated with hypertension."5.12Randomized study of angiotensin II type 1 receptor blocker vs dihydropiridine calcium antagonist for the treatment of paroxysmal atrial fibrillation in patients with hypertension. ( Aizawa, Y; Atarashi, H; Fukatani, M; Hirai, M; Hirayama, A; Inoue, H; Kamakura, S; Kato, T; Kodama, I; Koretsune, Y; Kumagai, K; Kurachi, Y; Mitamura, H; Nakaya, H; Ogawa, S; Ohe, T; Ohtsu, H; Okumura, K; Saikawa, T; Sakurai, M; Sugi, K; Watanabe, E; Yamashita, T; Yamazaki, T, 2006)
"Objectives For revealing the peculiarities of the drug-drug interaction of rivaroxaban (substrate CYP3A4 and P-gp) and calcium channel blockers (CCBs) (verapamil - inhibitor CYP3A4 and P-gp and amlodipine - substrate CYP3A4) in patients 80 years and older with nonvalvular atrial fibrillation (NAF) we studied 128 patients."3.96Drug-drug interaction of rivaroxaban and calcium channel blockers in patients aged 80 years and older with nonvalvular atrial fibrillation. ( Bahteeva, D; Bochkov, P; Cherniaeva, M; Golovina, O; Gorbatenkova, S; Kulikova, M; Mirzaev, K; Ostroumova, O; Rytkin, E; Shevchenko, R; Sychev, D, 2020)
"Study on the Effect of Irbesartan on Atrial Fibrillation Recurrence in Kumamoto (SILK study) is a prospective, multicenter, randomized, and open-label comparative evaluation of the effects of irbesartan and amlodipine on AF recurrence in hypertensive patients with AF who are scheduled to undergo catheter ablation or electrical cardioversion of AF."3.88Study on the Effect of Irbesartan on Atrial Fibrillation Recurrence in Kumamoto: Atrial Fibrillation Suppression Trial (SILK study). ( Fujimoto, K; Iwasa, A; Kaikita, K; Kajiwara, I; Koyama, J; Matsui, K; Matsumura, T; Morihisa, K; Morikami, Y; Ogawa, H; Tsujita, K; Tsunoda, R; Uemura, T; Yamabe, H, 2018)
"To assess effect of calcium antagonists amlodipine and verapamil on the risk of development of atrial fibrillation after coronary artery bypass surgery."3.72[Effect of calcium antagonists verapamil and amlodipine on the risk of development of atrial fibrillation after coronary artery bypass grafting]. ( Afanas'ev, SA; Akhmedov, ShD; Antonchenko, IV; Dzhavadova, GK; Evtushenko, AV; Kandinskiĭ, ML; Kozlov, BN; Popov, SV; Shipulin, VM; Vecherskiĭ, IuIu, 2003)
"Telmisartan was more effective than amlodipine in preventing AF recurrences in hypertensive patients with paroxysmal AF."2.77Effect of telmisartan on paroxysmal atrial fibrillation recurrence in hypertensive patients with normal or increased left atrial size. ( Derosa, G; Fogari, R; Maffioli, P; Mugellini, A; Perrone, T; Preti, P; Zoppi, A, 2012)
"Valsartan-based treatment reduced the development of new-onset AF, particularly sustained AF in hypertensive patients, compared with amlodipine-based therapy."2.73Reduced incidence of new-onset atrial fibrillation with angiotensin II receptor blockade: the VALUE trial. ( Hua, TA; Julius, S; Kjeldsen, SE; McInnes, GT; Schmieder, RE; Zanchetti, A, 2008)
"Hypertension is the most prevalent and potentially modifiable risk factor for AF."2.72Angiotensin Receptor Blocker and Calcium Channel Blocker Preventing Atrial Fibrillation Recurrence in Patients with Hypertension and Atrial Fibrillation: A Meta-analysis. ( Feng, J; Gan, Y; Jiang, H; Ma, H, 2021)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (43.75)29.6817
2010's7 (43.75)24.3611
2020's2 (12.50)2.80

Authors

AuthorsStudies
Sychev, D1
Mirzaev, K1
Cherniaeva, M1
Kulikova, M1
Bochkov, P1
Shevchenko, R1
Gorbatenkova, S1
Golovina, O1
Ostroumova, O1
Bahteeva, D1
Rytkin, E1
Ma, H1
Jiang, H1
Feng, J1
Gan, Y1
Yamabe, H1
Kaikita, K1
Matsumura, T1
Iwasa, A1
Koyama, J1
Uemura, T1
Morikami, Y1
Tsunoda, R1
Morihisa, K1
Fujimoto, K1
Kajiwara, I1
Matsui, K1
Tsujita, K1
Ogawa, H1
Dewland, TA1
Soliman, EZ2
Yamal, JM1
Davis, BR2
Alonso, A1
Albert, CM1
Simpson, LM2
Haywood, LJ2
Marcus, GM1
Piller, LB1
Ghosh, A1
Einhorn, PT1
Ford, CE1
Probstfield, JL1
Wright, JT1
Kario, K1
Hoshide, S1
Uchiyama, K1
Yoshida, T1
Okazaki, O1
Noshiro, T1
Aoki, H1
Mizuno, H1
Matsumoto, Y1
Fogari, R4
Derosa, G3
Ferrari, I1
Corradi, L3
Zoppi, A4
Lazzari, P2
Santoro, T1
Preti, P3
Mugellini, A4
Yamashita, T2
Inoue, H2
Okumura, K2
Kodama, I2
Aizawa, Y2
Atarashi, H2
Ohe, T2
Ohtsu, H2
Kato, T2
Kamakura, S2
Kumagai, K2
Kurachi, Y2
Koretsune, Y2
Saikawa, T2
Sakurai, M2
Sato, T1
Sugi, K2
Nakaya, H2
Hirai, M2
Hirayama, A2
Fukatani, M2
Mitamura, H2
Yamazaki, T2
Watanabe, E2
Ogawa, S2
Goette, A1
Maffioli, P1
Perrone, T1
Popov, SV1
Kandinskiĭ, ML1
Kozlov, BN1
Antonchenko, IV1
Evtushenko, AV1
Dzhavadova, GK1
Vecherskiĭ, IuIu1
Akhmedov, ShD1
Afanas'ev, SA1
Shipulin, VM1
Destro, M1
Fogari, E1
Rinaldi, A1
Higashide, T1
Okai, T1
Yoshida, S1
Tonoike, N1
Kakihara, M1
Mizumura, T1
Oshima, A1
Sugimura, Y1
Tamamura, T1
Ogata, I1
Schmieder, RE1
Kjeldsen, SE1
Julius, S1
McInnes, GT1
Zanchetti, A1
Hua, TA1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00000542]Phase 30 participants Interventional1993-08-31Completed
ARB and CCB Longest Combination Treatment on Ambulatory and Home BP in Hypertension With Atrial Fibrillation -Multicenter Study on Time of Dosing[NCT01748253]80 participants (Anticipated)Interventional2012-11-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for amlodipine and Atrial Fibrillation

ArticleYear
Angiotensin Receptor Blocker and Calcium Channel Blocker Preventing Atrial Fibrillation Recurrence in Patients with Hypertension and Atrial Fibrillation: A Meta-analysis.
    Cardiovascular therapeutics, 2021, Volume: 2021

    Topics: Amlodipine; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Atrial Fibri

2021

Trials

10 trials available for amlodipine and Atrial Fibrillation

ArticleYear
Pharmacologic Prevention of Incident Atrial Fibrillation: Long-Term Results From the ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial).
    Circulation. Arrhythmia and electrophysiology, 2017, Volume: 10, Issue:12

    Topics: Amlodipine; Antihypertensive Agents; Atrial Fibrillation; Atrial Flutter; Chlorthalidone; Double-Bli

2017
Risk Factors Influencing Outcomes of Atrial Fibrillation in ALLHAT.
    Journal of the National Medical Association, 2018, Volume: 110, Issue:4

    Topics: Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Atrial Fibrillation; Atrial Flutter; C

2018
Dose Timing of an Angiotensin II Receptor Blocker/Calcium Channel Blocker Combination in Hypertensive Patients With Paroxysmal Atrial Fibrillation.
    Journal of clinical hypertension (Greenwich, Conn.), 2016, Volume: 18, Issue:10

    Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Atrial Fibrillation; Benzimidazoles; Benzoates;

2016
Effect of valsartan and ramipril on atrial fibrillation recurrence and P-wave dispersion in hypertensive patients with recurrent symptomatic lone atrial fibrillation.
    American journal of hypertension, 2008, Volume: 21, Issue:9

    Topics: Aged; Amlodipine; Antihypertensive Agents; Atrial Fibrillation; Double-Blind Method; Electrocardiogr

2008
Randomized trial of angiotensin II-receptor blocker vs. dihydropiridine calcium channel blocker in the treatment of paroxysmal atrial fibrillation with hypertension (J-RHYTHM II study).
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2011, Volume: 13, Issue:4

    Topics: Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Atrial Fibrillation; Benzimidazoles; Biph

2011
Effect of telmisartan on paroxysmal atrial fibrillation recurrence in hypertensive patients with normal or increased left atrial size.
    Clinical cardiology, 2012, Volume: 35, Issue:6

    Topics: Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Atrial Fibrilla

2012
Losartan and prevention of atrial fibrillation recurrence in hypertensive patients.
    Journal of cardiovascular pharmacology, 2006, Volume: 47, Issue:1

    Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Atrial Fibrillation; Double-Blind Method; Female;

2006
Randomized study of angiotensin II type 1 receptor blocker vs dihydropiridine calcium antagonist for the treatment of paroxysmal atrial fibrillation in patients with hypertension.
    Circulation journal : official journal of the Japanese Circulation Society, 2006, Volume: 70, Issue:10

    Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Atrial Fibrillation; Benzimidazoles; Biphenyl C

2006
Reduced incidence of new-onset atrial fibrillation with angiotensin II receptor blockade: the VALUE trial.
    Journal of hypertension, 2008, Volume: 26, Issue:3

    Topics: Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Atrial Fibrillat

2008
Comparative evaluation of effect of valsartan/amlodipine and atenolol/amlodipine combinations on atrial fibrillation recurrence in hypertensive patients with type 2 diabetes mellitus.
    Journal of cardiovascular pharmacology, 2008, Volume: 51, Issue:3

    Topics: Aged; Amlodipine; Anti-Arrhythmia Agents; Antihypertensive Agents; Atenolol; Atrial Fibrillation; Bl

2008

Other Studies

5 other studies available for amlodipine and Atrial Fibrillation

ArticleYear
Drug-drug interaction of rivaroxaban and calcium channel blockers in patients aged 80 years and older with nonvalvular atrial fibrillation.
    Drug metabolism and personalized therapy, 2020, 09-04, Volume: 35, Issue:3

    Topics: Aged, 80 and over; Amlodipine; Atrial Fibrillation; Calcium Channel Blockers; Cross-Sectional Studie

2020
Study on the Effect of Irbesartan on Atrial Fibrillation Recurrence in Kumamoto: Atrial Fibrillation Suppression Trial (SILK study).
    Journal of cardiology, 2018, Volume: 71, Issue:2

    Topics: Aged; Amlodipine; Angiotensin Receptor Antagonists; Atrial Fibrillation; Biphenyl Compounds; Blood P

2018
The vanishing story of angiotensin II receptor blockers in the treatment of atrial fibrillation.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2011, Volume: 13, Issue:4

    Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Atrial Fibrillation; Benzimidazoles; Biphenyl C

2011
[Effect of calcium antagonists verapamil and amlodipine on the risk of development of atrial fibrillation after coronary artery bypass grafting].
    Kardiologiia, 2003, Volume: 43, Issue:7

    Topics: Adult; Aged; Amlodipine; Atrial Fibrillation; Calcium Channel Blockers; Coronary Artery Bypass; Huma

2003
[Basedow disease with recurrent syncopal attack and severe pulmonary hypertension].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2007, Apr-10, Volume: 96, Issue:4

    Topics: Aged; Amlodipine; Atrial Fibrillation; Digoxin; Female; Graves Disease; Humans; Hypertension, Pulmon

2007