amlexanox has been researched along with Epidermolysis Bullosa Dystrophica in 1 studies
amlexanox: SRA-A antagonist;structure given in first source
amlexanox : A pyridochromene-derived monocarboxylic acid having an amino substituent at the 2-position, an oxo substituent at the 5-position and an isopropyl substituent at the 7-position.
Epidermolysis Bullosa Dystrophica: Form of epidermolysis bullosa characterized by atrophy of blistered areas, severe scarring, and nail changes. It is most often present at birth or in early infancy and occurs in both autosomal dominant and recessive forms. All forms of dystrophic epidermolysis bullosa result from mutations in COLLAGEN TYPE VII, a major component fibrils of BASEMENT MEMBRANE and EPIDERMIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recessive dystrophic epidermolysis bullosa (RDEB) is a rare monogenic blistering disorder caused by the lack of functional type VII collagen, leading to skin fragility and subsequent trauma-induced separation of the epidermis from the underlying dermis." | 2.55 | Amlexanox Enhances Premature Termination Codon Read-Through in COL7A1 and Expression of Full Length Type VII Collagen: Potential Therapy for Recessive Dystrophic Epidermolysis Bullosa. ( Atanasova, VS; Bruckner-Tuderman, L; Chen, M; Gruber, C; Has, C; Jiang, Q; McGrath, JA; Piñón Hofbauer, J; Prisco, M; South, AP; Uitto, J, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Atanasova, VS | 1 |
| Jiang, Q | 1 |
| Prisco, M | 1 |
| Gruber, C | 1 |
| Piñón Hofbauer, J | 1 |
| Chen, M | 1 |
| Has, C | 1 |
| Bruckner-Tuderman, L | 1 |
| McGrath, JA | 1 |
| Uitto, J | 1 |
| South, AP | 1 |
1 review available for amlexanox and Epidermolysis Bullosa Dystrophica
| Article | Year |
|---|---|
Amlexanox Enhances Premature Termination Codon Read-Through in COL7A1 and Expression of Full Length Type VII Collagen: Potential Therapy for Recessive Dystrophic Epidermolysis Bullosa.
Topics: Aminopyridines; Codon, Nonsense; Collagen Type VII; Epidermolysis Bullosa Dystrophica; Female; Gene | 2017 |