amlexanox has been researched along with Diabetes Mellitus, Type 2 in 2 studies
amlexanox: SRA-A antagonist;structure given in first source
amlexanox : A pyridochromene-derived monocarboxylic acid having an amino substituent at the 2-position, an oxo substituent at the 5-position and an isopropyl substituent at the 7-position.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic low-grade inflammation is a hallmark of obesity, which is a risk factor for the development of type 2 diabetes." | 1.48 | Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKK ( Beyett, TS; Chang, L; Gan, X; Gomez, AV; Reilly, SM; Saltiel, AR; Showalter, HD; Tesmer, JJG, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oral, EA | 1 |
| Reilly, SM | 2 |
| Gomez, AV | 2 |
| Meral, R | 1 |
| Butz, L | 1 |
| Ajluni, N | 1 |
| Chenevert, TL | 1 |
| Korytnaya, E | 1 |
| Neidert, AH | 1 |
| Hench, R | 1 |
| Rus, D | 1 |
| Horowitz, JF | 1 |
| Poirier, B | 1 |
| Zhao, P | 1 |
| Lehmann, K | 1 |
| Jain, M | 1 |
| Yu, R | 1 |
| Liddle, C | 1 |
| Ahmadian, M | 1 |
| Downes, M | 1 |
| Evans, RM | 1 |
| Saltiel, AR | 2 |
| Beyett, TS | 1 |
| Gan, X | 1 |
| Chang, L | 1 |
| Showalter, HD | 1 |
| Tesmer, JJG | 1 |
1 trial available for amlexanox and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Inhibition of IKKÉ› and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes.
Topics: Aged; Aminopyridines; Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Energy Metaboli | 2017 |
1 other study available for amlexanox and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKK
Topics: 3T3-L1 Cells; Adipocytes; Aminopyridines; Animals; Carboxylic Acids; Cell Line; Diabetes Mellitus, T | 2018 |