amlexanox has been researched along with Breast Cancer in 2 studies
amlexanox: SRA-A antagonist;structure given in first source
amlexanox : A pyridochromene-derived monocarboxylic acid having an amino substituent at the 2-position, an oxo substituent at the 5-position and an isopropyl substituent at the 7-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These effects were mediated by the breast cancer oncogene IKKε and its downstream target-the serine biosynthesis pathway as demonstrated by genetic or pharmacological tools." | 1.56 | Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway. ( Bentham, RB; Bianchi, K; Carter, E; Dalli, J; Godinho, SA; Grose, R; Hodivala-Dilke, K; Holdsworth, J; Ironside, A; Jones, L; Jones, W; Mataloni, I; Moreno Béjar, R; Szabadkai, G; Uhlik, L; Wilcz-Villega, E; Xu, R, 2020) |
| "Functional and mechanistic studies in breast cancer cells, osteoclasts and osteoblasts revealed that IKKε inhibition reduces the ability of breast cancer cells to grow, move and enhance osteoclastogenesis by engaging both IRF and NFκB signalling pathways." | 1.51 | Pharmacological inhibition of the IKKε/TBK-1 axis potentiates the anti-tumour and anti-metastatic effects of Docetaxel in mouse models of breast cancer. ( Allen, RJ; Bishop, RT; de Ridder, D; Idris, AI; Lefley, DV; Marino, S; Ottewell, PD; Sims, AH; Wang, N, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wilcz-Villega, E | 1 |
| Carter, E | 1 |
| Ironside, A | 1 |
| Xu, R | 1 |
| Mataloni, I | 1 |
| Holdsworth, J | 1 |
| Jones, W | 1 |
| Moreno Béjar, R | 1 |
| Uhlik, L | 1 |
| Bentham, RB | 1 |
| Godinho, SA | 1 |
| Dalli, J | 1 |
| Grose, R | 1 |
| Szabadkai, G | 1 |
| Jones, L | 1 |
| Hodivala-Dilke, K | 1 |
| Bianchi, K | 1 |
| Bishop, RT | 1 |
| Marino, S | 1 |
| de Ridder, D | 1 |
| Allen, RJ | 1 |
| Lefley, DV | 1 |
| Sims, AH | 1 |
| Wang, N | 1 |
| Ottewell, PD | 1 |
| Idris, AI | 1 |
2 other studies available for amlexanox and Breast Cancer
| Article | Year |
|---|---|
Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway.
Topics: Aminopyridines; Animals; Breast Neoplasms; Culture Media, Conditioned; Epithelial Cells; Female; Hum | 2020 |
Pharmacological inhibition of the IKKε/TBK-1 axis potentiates the anti-tumour and anti-metastatic effects of Docetaxel in mouse models of breast cancer.
Topics: Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line | 2019 |