amlexanox has been researched along with Asthma in 11 studies
amlexanox: SRA-A antagonist;structure given in first source
amlexanox : A pyridochromene-derived monocarboxylic acid having an amino substituent at the 2-position, an oxo substituent at the 5-position and an isopropyl substituent at the 7-position.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Excerpt | Relevance | Reference |
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"Recently, we have reported that a nebulized solution of sodium cromoglycate (SCG) (Intal), a well known antiallergic agent, has an acute bronchodilator effect in patients with aspirin-induced asthma (AIA)." | 9.07 | [Amlexanox has an acute bronchodilator effect in patients with aspirin-induced asthma (AIA)]. ( Chida, K; Hayakawa, H; Imokawa, S; Nakazawa, K; Satou, A; Taniguchi, M; Toyoshima, M, 1993) |
"Recently, we have reported that a nebulized solution of sodium cromoglycate (SCG) (Intal), a well known antiallergic agent, has an acute bronchodilator effect in patients with aspirin-induced asthma (AIA)." | 5.07 | [Amlexanox has an acute bronchodilator effect in patients with aspirin-induced asthma (AIA)]. ( Chida, K; Hayakawa, H; Imokawa, S; Nakazawa, K; Satou, A; Taniguchi, M; Toyoshima, M, 1993) |
"The effects of a newly synthesized pyridazinone derivative, NZ-107, 4-bromo-5-(3-ethoxy-4-methoxybenzylamino)-3(2H)-pyridazinone, and two well-known antiasthmatic drugs, amlexanox (orally active disodium cromoglycate-like drug) and disodium cromoglycate (DSCG) on antigen-, histamine- and leukotriene C4 (LTC4)-induced constriction of isolated human tracheal muscle, and histamine release from human lung tissues and leukocytes were investigated in vitro." | 3.68 | Effect of NZ-107, a newly synthesized pyridazinone derivative, on antigen-induced contraction of human bronchial strips and histamine release from human lung fragments or leukocytes. ( Daikoku, M; Iwama, T; Koda, A; Nagai, H; Suda, H; Yanagihara, Y, 1992) |
"Amlexanox has also been legally utilized and administered in Japan as a treatment for asthma, a chronic pulmonary disease characterized by inflammation of the lower respiratory tract." | 2.66 | Amlexanox: A Novel Therapeutic for Atopic, Metabolic, and Inflammatory Disease. ( Dosanjh, A; Won, CY, 2020) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (27.27) | 18.7374 |
1990's | 5 (45.45) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (9.09) | 24.3611 |
2020's | 2 (18.18) | 2.80 |
Authors | Studies |
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Deng, J | 1 |
Tang, H | 1 |
Zhang, Y | 1 |
Yuan, X | 1 |
Ma, N | 1 |
Hu, H | 1 |
Wang, X | 2 |
Liu, C | 1 |
Xu, G | 1 |
Li, Y | 1 |
Wang, S | 1 |
Guo, L | 1 |
Ozasa, K | 1 |
Temizoz, B | 1 |
Kusakabe, T | 1 |
Kobari, S | 1 |
Momota, M | 1 |
Coban, C | 1 |
Ito, S | 1 |
Kobiyama, K | 1 |
Kuroda, E | 1 |
Ishii, KJ | 1 |
Dosanjh, A | 1 |
Won, CY | 1 |
Imokawa, S | 1 |
Satou, A | 1 |
Taniguchi, M | 1 |
Toyoshima, M | 1 |
Nakazawa, K | 1 |
Hayakawa, H | 1 |
Chida, K | 1 |
Nagai, H | 2 |
Suda, H | 1 |
Iwama, T | 1 |
Daikoku, M | 1 |
Yanagihara, Y | 1 |
Koda, A | 2 |
Inagaki, M | 1 |
Michimata, H | 1 |
Minato, K | 1 |
Sunaga, Y | 1 |
Kobayashi, S | 1 |
Tani, G | 1 |
Nakazawa, T | 1 |
Urisu, A | 1 |
Iimi, K | 1 |
Kondo, Y | 1 |
Horiba, F | 1 |
Masuda, S | 1 |
Tsuruta, M | 1 |
Yazaki, T | 1 |
Torii, S | 1 |
Makino, E | 1 |
Ohashi, T | 1 |
Takahashi, H | 1 |
Kato, H | 1 |
Ito, Y | 1 |
Azuma, H | 1 |
Saijo, T | 2 |
Kuriki, H | 3 |
Ashida, Y | 2 |
Makino, H | 2 |
Maki, Y | 2 |
Tamura, S | 1 |
Terao, S | 1 |
Ukawa, K | 1 |
Ishiguro, T | 1 |
Nohara, A | 1 |
1 review available for amlexanox and Asthma
Article | Year |
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Amlexanox: A Novel Therapeutic for Atopic, Metabolic, and Inflammatory Disease.
Topics: Aminopyridines; Animals; Anti-Allergic Agents; Asthma; Humans; Hypersensitivity, Immediate; Inflamma | 2020 |
1 trial available for amlexanox and Asthma
Article | Year |
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[Amlexanox has an acute bronchodilator effect in patients with aspirin-induced asthma (AIA)].
Topics: Adult; Aged; Aminopyridines; Aspirin; Asthma; Bronchi; Bronchoconstriction; Bronchodilator Agents; D | 1993 |
9 other studies available for amlexanox and Asthma
Article | Year |
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House dust mite-induced endoplasmic reticulum stress mediates MUC5AC hypersecretion via TBK1 in airway epithelium.
Topics: Animals; Asthma; Endoplasmic Reticulum Stress; Epithelium; Humans; Mice; Mucin 5AC; Protein Serine-T | 2023 |
Cyclic GMP-AMP Triggers Asthma in an IL-33-Dependent Manner That Is Blocked by Amlexanox, a TBK1 Inhibitor.
Topics: Allergens; Aminopyridines; Animals; Asthma; Bronchoalveolar Lavage Fluid; Eosinophils; Female; Immun | 2019 |
Effect of NZ-107, a newly synthesized pyridazinone derivative, on antigen-induced contraction of human bronchial strips and histamine release from human lung fragments or leukocytes.
Topics: Aminopyridines; Asthma; Bronchi; Bronchoconstriction; Cromolyn Sodium; Histamine; Histamine Release; | 1992 |
[Inhibitory effect of amlexanox on asthmatic attacks in an aspirin sensitive asthmatic].
Topics: Adolescent; Aminopyridines; Aspirin; Asthma; Drug Hypersensitivity; Female; Humans; SRS-A | 1992 |
[Inhibitory action amlexanox on interleukin-3-induced enhancement of histamine releasability of human leukocytes].
Topics: Adult; Aminopyridines; Asthma; Drug Synergism; Female; Histamine Release; Humans; Immunoglobulin E; | 1990 |
Inhibitory effect of HSR-6071, a new anti-allergic agent, on experimental asthma in rats and guinea-pigs.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Animals; Asthma; Azoles; Bronchi; Cromolyn Sodi | 1990 |
Inhibition by amoxanox (AA-673) of the immunologically, leukotriene D4- or platelet-activating factor-stimulated bronchoconstriction in guinea pigs and rats.
Topics: Aminopyridines; Animals; Asthma; Bronchi; Cromolyn Sodium; Epidermal Growth Factor; Female; Guinea P | 1985 |
The antiallergic agent amoxanox suppresses SRS-A generation by inhibiting lipoxygenase.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 5,8,11,14-Eicosatetraynoic Acid; Aminopyridines; Animals | 1986 |
Synthesis of the metabolites and degradation products of 2-amino-7-isopropyl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3- carboxylic acid (Amoxanox).
Topics: Aminopyridines; Animals; Asthma; Biotransformation; Passive Cutaneous Anaphylaxis; Rats | 1985 |