amlexanox and Asthma
amlexanox has been researched along with Asthma in 11 studies
amlexanox: SRA-A antagonist;structure given in first source
amlexanox : A pyridochromene-derived monocarboxylic acid having an amino substituent at the 2-position, an oxo substituent at the 5-position and an isopropyl substituent at the 7-position.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recently, we have reported that a nebulized solution of sodium cromoglycate (SCG) (Intal), a well known antiallergic agent, has an acute bronchodilator effect in patients with aspirin-induced asthma (AIA)." | 9.07 | [Amlexanox has an acute bronchodilator effect in patients with aspirin-induced asthma (AIA)]. ( Chida, K; Hayakawa, H; Imokawa, S; Nakazawa, K; Satou, A; Taniguchi, M; Toyoshima, M, 1993) |
| "Recently, we have reported that a nebulized solution of sodium cromoglycate (SCG) (Intal), a well known antiallergic agent, has an acute bronchodilator effect in patients with aspirin-induced asthma (AIA)." | 5.07 | [Amlexanox has an acute bronchodilator effect in patients with aspirin-induced asthma (AIA)]. ( Chida, K; Hayakawa, H; Imokawa, S; Nakazawa, K; Satou, A; Taniguchi, M; Toyoshima, M, 1993) |
| "The effects of a newly synthesized pyridazinone derivative, NZ-107, 4-bromo-5-(3-ethoxy-4-methoxybenzylamino)-3(2H)-pyridazinone, and two well-known antiasthmatic drugs, amlexanox (orally active disodium cromoglycate-like drug) and disodium cromoglycate (DSCG) on antigen-, histamine- and leukotriene C4 (LTC4)-induced constriction of isolated human tracheal muscle, and histamine release from human lung tissues and leukocytes were investigated in vitro." | 3.68 | Effect of NZ-107, a newly synthesized pyridazinone derivative, on antigen-induced contraction of human bronchial strips and histamine release from human lung fragments or leukocytes. ( Daikoku, M; Iwama, T; Koda, A; Nagai, H; Suda, H; Yanagihara, Y, 1992) |
| "Amlexanox has also been legally utilized and administered in Japan as a treatment for asthma, a chronic pulmonary disease characterized by inflammation of the lower respiratory tract." | 2.66 | Amlexanox: A Novel Therapeutic for Atopic, Metabolic, and Inflammatory Disease. ( Dosanjh, A; Won, CY, 2020) |
Research
Studies (11)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Deng, J | 1 |
| Tang, H | 1 |
| Zhang, Y | 1 |
| Yuan, X | 1 |
| Ma, N | 1 |
| Hu, H | 1 |
| Wang, X | 2 |
| Liu, C | 1 |
| Xu, G | 1 |
| Li, Y | 1 |
| Wang, S | 1 |
| Guo, L | 1 |
| Ozasa, K | 1 |
| Temizoz, B | 1 |
| Kusakabe, T | 1 |
| Kobari, S | 1 |
| Momota, M | 1 |
| Coban, C | 1 |
| Ito, S | 1 |
| Kobiyama, K | 1 |
| Kuroda, E | 1 |
| Ishii, KJ | 1 |
| Dosanjh, A | 1 |
| Won, CY | 1 |
| Imokawa, S | 1 |
| Satou, A | 1 |
| Taniguchi, M | 1 |
| Toyoshima, M | 1 |
| Nakazawa, K | 1 |
| Hayakawa, H | 1 |
| Chida, K | 1 |
| Nagai, H | 2 |
| Suda, H | 1 |
| Iwama, T | 1 |
| Daikoku, M | 1 |
| Yanagihara, Y | 1 |
| Koda, A | 2 |
| Inagaki, M | 1 |
| Michimata, H | 1 |
| Minato, K | 1 |
| Sunaga, Y | 1 |
| Kobayashi, S | 1 |
| Tani, G | 1 |
| Nakazawa, T | 1 |
| Urisu, A | 1 |
| Iimi, K | 1 |
| Kondo, Y | 1 |
| Horiba, F | 1 |
| Masuda, S | 1 |
| Tsuruta, M | 1 |
| Yazaki, T | 1 |
| Torii, S | 1 |
| Makino, E | 1 |
| Ohashi, T | 1 |
| Takahashi, H | 1 |
| Kato, H | 1 |
| Ito, Y | 1 |
| Azuma, H | 1 |
| Saijo, T | 2 |
| Kuriki, H | 3 |
| Ashida, Y | 2 |
| Makino, H | 2 |
| Maki, Y | 2 |
| Tamura, S | 1 |
| Terao, S | 1 |
| Ukawa, K | 1 |
| Ishiguro, T | 1 |
| Nohara, A | 1 |
Reviews
1 review available for amlexanox and Asthma
| Article | Year |
|---|---|
Amlexanox: A Novel Therapeutic for Atopic, Metabolic, and Inflammatory Disease.
Topics: Aminopyridines; Animals; Anti-Allergic Agents; Asthma; Humans; Hypersensitivity, Immediate; Inflamma | 2020 |
Trials
1 trial available for amlexanox and Asthma
| Article | Year |
|---|---|
[Amlexanox has an acute bronchodilator effect in patients with aspirin-induced asthma (AIA)].
Topics: Adult; Aged; Aminopyridines; Aspirin; Asthma; Bronchi; Bronchoconstriction; Bronchodilator Agents; D | 1993 |
Other Studies
9 other studies available for amlexanox and Asthma
| Article | Year |
|---|---|
House dust mite-induced endoplasmic reticulum stress mediates MUC5AC hypersecretion via TBK1 in airway epithelium.
Topics: Animals; Asthma; Endoplasmic Reticulum Stress; Epithelium; Humans; Mice; Mucin 5AC; Protein Serine-T | 2023 |
Cyclic GMP-AMP Triggers Asthma in an IL-33-Dependent Manner That Is Blocked by Amlexanox, a TBK1 Inhibitor.
Topics: Allergens; Aminopyridines; Animals; Asthma; Bronchoalveolar Lavage Fluid; Eosinophils; Female; Immun | 2019 |
Effect of NZ-107, a newly synthesized pyridazinone derivative, on antigen-induced contraction of human bronchial strips and histamine release from human lung fragments or leukocytes.
Topics: Aminopyridines; Asthma; Bronchi; Bronchoconstriction; Cromolyn Sodium; Histamine; Histamine Release; | 1992 |
[Inhibitory effect of amlexanox on asthmatic attacks in an aspirin sensitive asthmatic].
Topics: Adolescent; Aminopyridines; Aspirin; Asthma; Drug Hypersensitivity; Female; Humans; SRS-A | 1992 |
[Inhibitory action amlexanox on interleukin-3-induced enhancement of histamine releasability of human leukocytes].
Topics: Adult; Aminopyridines; Asthma; Drug Synergism; Female; Histamine Release; Humans; Immunoglobulin E; | 1990 |
Inhibitory effect of HSR-6071, a new anti-allergic agent, on experimental asthma in rats and guinea-pigs.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Animals; Asthma; Azoles; Bronchi; Cromolyn Sodi | 1990 |
Inhibition by amoxanox (AA-673) of the immunologically, leukotriene D4- or platelet-activating factor-stimulated bronchoconstriction in guinea pigs and rats.
Topics: Aminopyridines; Animals; Asthma; Bronchi; Cromolyn Sodium; Epidermal Growth Factor; Female; Guinea P | 1985 |
The antiallergic agent amoxanox suppresses SRS-A generation by inhibiting lipoxygenase.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 5,8,11,14-Eicosatetraynoic Acid; Aminopyridines; Animals | 1986 |
Synthesis of the metabolites and degradation products of 2-amino-7-isopropyl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3- carboxylic acid (Amoxanox).
Topics: Aminopyridines; Animals; Asthma; Biotransformation; Passive Cutaneous Anaphylaxis; Rats | 1985 |