Page last updated: 2024-10-22

amlexanox and Asthma

amlexanox has been researched along with Asthma in 11 studies

amlexanox: SRA-A antagonist;structure given in first source
amlexanox : A pyridochromene-derived monocarboxylic acid having an amino substituent at the 2-position, an oxo substituent at the 5-position and an isopropyl substituent at the 7-position.

Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Research Excerpts

ExcerptRelevanceReference
"Recently, we have reported that a nebulized solution of sodium cromoglycate (SCG) (Intal), a well known antiallergic agent, has an acute bronchodilator effect in patients with aspirin-induced asthma (AIA)."9.07[Amlexanox has an acute bronchodilator effect in patients with aspirin-induced asthma (AIA)]. ( Chida, K; Hayakawa, H; Imokawa, S; Nakazawa, K; Satou, A; Taniguchi, M; Toyoshima, M, 1993)
"Recently, we have reported that a nebulized solution of sodium cromoglycate (SCG) (Intal), a well known antiallergic agent, has an acute bronchodilator effect in patients with aspirin-induced asthma (AIA)."5.07[Amlexanox has an acute bronchodilator effect in patients with aspirin-induced asthma (AIA)]. ( Chida, K; Hayakawa, H; Imokawa, S; Nakazawa, K; Satou, A; Taniguchi, M; Toyoshima, M, 1993)
"The effects of a newly synthesized pyridazinone derivative, NZ-107, 4-bromo-5-(3-ethoxy-4-methoxybenzylamino)-3(2H)-pyridazinone, and two well-known antiasthmatic drugs, amlexanox (orally active disodium cromoglycate-like drug) and disodium cromoglycate (DSCG) on antigen-, histamine- and leukotriene C4 (LTC4)-induced constriction of isolated human tracheal muscle, and histamine release from human lung tissues and leukocytes were investigated in vitro."3.68Effect of NZ-107, a newly synthesized pyridazinone derivative, on antigen-induced contraction of human bronchial strips and histamine release from human lung fragments or leukocytes. ( Daikoku, M; Iwama, T; Koda, A; Nagai, H; Suda, H; Yanagihara, Y, 1992)
"Amlexanox has also been legally utilized and administered in Japan as a treatment for asthma, a chronic pulmonary disease characterized by inflammation of the lower respiratory tract."2.66Amlexanox: A Novel Therapeutic for Atopic, Metabolic, and Inflammatory Disease. ( Dosanjh, A; Won, CY, 2020)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19903 (27.27)18.7374
1990's5 (45.45)18.2507
2000's0 (0.00)29.6817
2010's1 (9.09)24.3611
2020's2 (18.18)2.80

Authors

AuthorsStudies
Deng, J1
Tang, H1
Zhang, Y1
Yuan, X1
Ma, N1
Hu, H1
Wang, X2
Liu, C1
Xu, G1
Li, Y1
Wang, S1
Guo, L1
Ozasa, K1
Temizoz, B1
Kusakabe, T1
Kobari, S1
Momota, M1
Coban, C1
Ito, S1
Kobiyama, K1
Kuroda, E1
Ishii, KJ1
Dosanjh, A1
Won, CY1
Imokawa, S1
Satou, A1
Taniguchi, M1
Toyoshima, M1
Nakazawa, K1
Hayakawa, H1
Chida, K1
Nagai, H2
Suda, H1
Iwama, T1
Daikoku, M1
Yanagihara, Y1
Koda, A2
Inagaki, M1
Michimata, H1
Minato, K1
Sunaga, Y1
Kobayashi, S1
Tani, G1
Nakazawa, T1
Urisu, A1
Iimi, K1
Kondo, Y1
Horiba, F1
Masuda, S1
Tsuruta, M1
Yazaki, T1
Torii, S1
Makino, E1
Ohashi, T1
Takahashi, H1
Kato, H1
Ito, Y1
Azuma, H1
Saijo, T2
Kuriki, H3
Ashida, Y2
Makino, H2
Maki, Y2
Tamura, S1
Terao, S1
Ukawa, K1
Ishiguro, T1
Nohara, A1

Reviews

1 review available for amlexanox and Asthma

ArticleYear
Amlexanox: A Novel Therapeutic for Atopic, Metabolic, and Inflammatory Disease.
    The Yale journal of biology and medicine, 2020, Volume: 93, Issue:5

    Topics: Aminopyridines; Animals; Anti-Allergic Agents; Asthma; Humans; Hypersensitivity, Immediate; Inflamma

2020

Trials

1 trial available for amlexanox and Asthma

ArticleYear
[Amlexanox has an acute bronchodilator effect in patients with aspirin-induced asthma (AIA)].
    Nihon Kyobu Shikkan Gakkai zasshi, 1993, Volume: 31, Issue:8

    Topics: Adult; Aged; Aminopyridines; Aspirin; Asthma; Bronchi; Bronchoconstriction; Bronchodilator Agents; D

1993

Other Studies

9 other studies available for amlexanox and Asthma

ArticleYear
House dust mite-induced endoplasmic reticulum stress mediates MUC5AC hypersecretion via TBK1 in airway epithelium.
    Experimental lung research, 2023, Volume: 49, Issue:1

    Topics: Animals; Asthma; Endoplasmic Reticulum Stress; Epithelium; Humans; Mice; Mucin 5AC; Protein Serine-T

2023
Cyclic GMP-AMP Triggers Asthma in an IL-33-Dependent Manner That Is Blocked by Amlexanox, a TBK1 Inhibitor.
    Frontiers in immunology, 2019, Volume: 10

    Topics: Allergens; Aminopyridines; Animals; Asthma; Bronchoalveolar Lavage Fluid; Eosinophils; Female; Immun

2019
Effect of NZ-107, a newly synthesized pyridazinone derivative, on antigen-induced contraction of human bronchial strips and histamine release from human lung fragments or leukocytes.
    International archives of allergy and immunology, 1992, Volume: 98, Issue:1

    Topics: Aminopyridines; Asthma; Bronchi; Bronchoconstriction; Cromolyn Sodium; Histamine; Histamine Release;

1992
[Inhibitory effect of amlexanox on asthmatic attacks in an aspirin sensitive asthmatic].
    Nihon Kyobu Shikkan Gakkai zasshi, 1992, Volume: 30, Issue:6

    Topics: Adolescent; Aminopyridines; Aspirin; Asthma; Drug Hypersensitivity; Female; Humans; SRS-A

1992
[Inhibitory action amlexanox on interleukin-3-induced enhancement of histamine releasability of human leukocytes].
    Arerugi = [Allergy], 1990, Volume: 39, Issue:10

    Topics: Adult; Aminopyridines; Asthma; Drug Synergism; Female; Histamine Release; Humans; Immunoglobulin E;

1990
Inhibitory effect of HSR-6071, a new anti-allergic agent, on experimental asthma in rats and guinea-pigs.
    The Journal of pharmacy and pharmacology, 1990, Volume: 42, Issue:4

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Animals; Asthma; Azoles; Bronchi; Cromolyn Sodi

1990
Inhibition by amoxanox (AA-673) of the immunologically, leukotriene D4- or platelet-activating factor-stimulated bronchoconstriction in guinea pigs and rats.
    International archives of allergy and applied immunology, 1985, Volume: 77, Issue:3

    Topics: Aminopyridines; Animals; Asthma; Bronchi; Cromolyn Sodium; Epidermal Growth Factor; Female; Guinea P

1985
The antiallergic agent amoxanox suppresses SRS-A generation by inhibiting lipoxygenase.
    International archives of allergy and applied immunology, 1986, Volume: 79, Issue:3

    Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 5,8,11,14-Eicosatetraynoic Acid; Aminopyridines; Animals

1986
Synthesis of the metabolites and degradation products of 2-amino-7-isopropyl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3- carboxylic acid (Amoxanox).
    Chemical & pharmaceutical bulletin, 1985, Volume: 33, Issue:10

    Topics: Aminopyridines; Animals; Asthma; Biotransformation; Passive Cutaneous Anaphylaxis; Rats

1985