Page last updated: 2024-10-22

amlexanox and Aphthae

amlexanox has been researched along with Aphthae in 17 studies

amlexanox: SRA-A antagonist;structure given in first source
amlexanox : A pyridochromene-derived monocarboxylic acid having an amino substituent at the 2-position, an oxo substituent at the 5-position and an isopropyl substituent at the 7-position.

Research Excerpts

ExcerptRelevanceReference
"041)] was the most effective in reducing the pain score followed by Amlexanox [MD, -2."5.41COMPARATIVE EFFICACY OF THERAPEUTIC INTERVENTIONS FOR THE MANAGEMENT OF RECURRENT APHTHOUS ULCERS: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS. ( Cheng, YO; Gopinath, D; Shetty, NY; Syeed, MS; Veettil, SK, 2023)
"Amlexanox oral adhesive tablets are effective and safe in reducing aphthous ulcer pain and lesion size, as well as erythema and exudation in this Chinese cohort."5.12An evaluation on the efficacy and safety of amlexanox oral adhesive tablets in the treatment of recurrent minor aphthous ulceration in a Chinese cohort: a randomized, double-blind, vehicle-controlled, unparallel multicenter clinical trial. ( Cai, Y; Chen, F; Chen, Q; Lin, M; Liu, J; Shi, J; Wang, Y; Wang, Z; Zeng, X; Zhang, Y; Zhou, H, 2006)
"Both amlexanox and LLLT were equally effective in relieving pain associated with minor aphthous stomatitis."2.82Low-level laser therapy versus 5% amlexanox: a comparison of treatment effects in a cohort of patients with minor aphthous ulcers. ( Anjana, R; Jaishankar, HP; Jijin, MJ; Kavitha, AP; Krupashankar, R; Pai, J; Rakaraddi, M; Shobha, R, 2016)
"Amlexanox has been developed as a 5 percent topical oral paste for the treatment of patients with recurrent aphthous stomatitis (RAS) in most European countries."2.74A clinical evaluation of amlexanox oral adhesive pellicles in the treatment of recurrent aphthous stomatitis and comparison with amlexanox oral tablets: a randomized, placebo controlled, blinded, multicenter clinical trial. ( Chen, Q; Chen, R; Dong, Y; Gao, F; Jiang, L; Lin, M; Liu, J; Meng, W; Wang, Z; Xu, T; Zeng, X; Zhong, X; Zhou, H, 2009)
" Minimal adverse experiences were observed with the 991 subjects that were exposed to 5% Amlexanox paste."2.685% amlexanox oral paste, a new treatment for recurrent minor aphthous ulcers: II. Pharmacokinetics and demonstration of clinical safety. ( Alfano, MC; Charney, MR; Khandwala, A; Van Inwegen, RG, 1997)
"Levamisole has shown variable efficacy in reducing ulcer frequency and duration in patients with minor RAU."2.41Treatment strategies for recurrent oral aphthous ulcers. ( Barrons, RW, 2001)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (23.53)18.2507
2000's9 (52.94)29.6817
2010's3 (17.65)24.3611
2020's1 (5.88)2.80

Authors

AuthorsStudies
Cheng, YO1
Veettil, SK1
Syeed, MS1
Shetty, NY1
Gopinath, D1
Jijin, MJ1
Rakaraddi, M1
Pai, J1
Jaishankar, HP1
Krupashankar, R1
Kavitha, AP1
Anjana, R1
Shobha, R1
Pentapati, KC1
Smriti, K1
Gadicherla, S1
Höger, P1
Meng, W1
Dong, Y1
Liu, J2
Wang, Z2
Zhong, X1
Chen, R1
Zhou, H2
Lin, M2
Jiang, L1
Gao, F1
Xu, T1
Chen, Q2
Zeng, X2
Bailey, J1
McCarthy, C1
Smith, RF1
Murray, B2
McGuinness, N1
Biagioni, P1
Hyland, P1
Lamey, PJ2
Biagioni, PA1
Cai, Y1
Chen, F1
Wang, Y1
Shi, J1
Zhang, Y1
Rodríguez, M1
Rubio, JA1
Sanchez, R1
Burgess, JA1
van der Ven, PF1
Martin, M1
Sherman, J1
Haley, J1
Greer, RO1
Lindenmuth, JE1
Juarez, T1
Khandwala, A4
Van Inwegen, RG2
Charney, MR1
Alfano, MC2
Binnie, WH1
Curro, FA1
Van Inwegan, RG1
Barrons, RW1
Eisen, D1
Lynch, DP1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Nonaromatic Naphthalan - Composition Study and Biological Effects on Epithelial Tissues[NCT02920658]Phase 257 participants (Actual)Interventional2010-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for amlexanox and Aphthae

ArticleYear
COMPARATIVE EFFICACY OF THERAPEUTIC INTERVENTIONS FOR THE MANAGEMENT OF RECURRENT APHTHOUS ULCERS: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS.
    The journal of evidence-based dental practice, 2023, Volume: 23, Issue:4

    Topics: Aminopyridines; Humans; Network Meta-Analysis; Pain; Stomatitis, Aphthous

2023
Clinical inquiry. What is the most effective way to treat recurrent canker sores?
    The Journal of family practice, 2011, Volume: 60, Issue:10

    Topics: Administration, Topical; Aminopyridines; Anti-Allergic Agents; Anti-Infective Agents, Local; Anti-In

2011
Review of over-the-counter treatments for aphthous ulceration and results from use of a dissolving oral patch containing glycyrrhiza complex herbal extract.
    The journal of contemporary dental practice, 2008, Mar-01, Volume: 9, Issue:3

    Topics: Aminopyridines; Anesthetics, Local; Cyanoacrylates; Glycyrrhiza; Hematinics; Humans; Mouthwashes; No

2008
Treatment strategies for recurrent oral aphthous ulcers.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2001, Jan-01, Volume: 58, Issue:1

    Topics: Adjuvants, Immunologic; Administration, Topical; Adrenal Cortex Hormones; Aminopyridines; Anti-Infla

2001
Selecting topical and systemic agents for recurrent aphthous stomatitis.
    Cutis, 2001, Volume: 68, Issue:3

    Topics: Administration, Topical; Aminopyridines; Anti-Inflammatory Agents; Humans; Prednisone; Recurrence; S

2001

Trials

10 trials available for amlexanox and Aphthae

ArticleYear
Low-level laser therapy versus 5% amlexanox: a comparison of treatment effects in a cohort of patients with minor aphthous ulcers.
    Oral surgery, oral medicine, oral pathology and oral radiology, 2016, Volume: 121, Issue:3

    Topics: Adolescent; Adult; Aminopyridines; Anti-Allergic Agents; Female; Humans; India; Low-Level Light Ther

2016
A clinical evaluation of amlexanox oral adhesive pellicles in the treatment of recurrent aphthous stomatitis and comparison with amlexanox oral tablets: a randomized, placebo controlled, blinded, multicenter clinical trial.
    Trials, 2009, May-06, Volume: 10

    Topics: Adhesiveness; Administration, Oral; Aminopyridines; Anti-Allergic Agents; China; Double-Blind Method

2009
A comparative study of the efficacy of Aphtheal in the management of recurrent minor aphthous ulceration.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2005, Volume: 34, Issue:7

    Topics: Adult; Aminopyridines; Anti-Allergic Agents; Body Temperature; Erythema; Female; Humans; Male; Secon

2005
The efficacy of amlexanox OraDisc on the prevention of recurrent minor aphthous ulceration.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2006, Volume: 35, Issue:2

    Topics: Administration, Topical; Adult; Aminopyridines; Anti-Allergic Agents; Body Temperature; Double-Blind

2006
An evaluation on the efficacy and safety of amlexanox oral adhesive tablets in the treatment of recurrent minor aphthous ulceration in a Chinese cohort: a randomized, double-blind, vehicle-controlled, unparallel multicenter clinical trial.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2006, Volume: 102, Issue:4

    Topics: Adhesives; Adolescent; Adult; Aged; Aminopyridines; Anti-Allergic Agents; Cohort Studies; Double-Bli

2006
Effectiveness of two oral pastes for the treatment of recurrent aphthous stomatitis.
    Oral diseases, 2007, Volume: 13, Issue:5

    Topics: Aminopyridines; Analysis of Variance; Anti-Allergic Agents; Anti-Inflammatory Agents; Clobetasol; Do

2007
A double-blind study of topically applied 5% amlexanox in the treatment of aphthous ulcers.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1993, Volume: 51, Issue:3

    Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Aged; Aminopyridines; Anti-Inflamm

1993
5% amlexanox oral paste, a new treatment for recurrent minor aphthous ulcers: II. Pharmacokinetics and demonstration of clinical safety.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 1997, Volume: 83, Issue:2

    Topics: Administration, Topical; Adult; Aminopyridines; Anti-Inflammatory Agents; Area Under Curve; Dose-Res

1997
5% amlexanox oral paste, a new treatment for recurrent minor aphthous ulcers: I. Clinical demonstration of acceleration of healing and resolution of pain.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 1997, Volume: 83, Issue:2

    Topics: Administration, Topical; Adult; Aminopyridines; Analysis of Variance; Anti-Inflammatory Agents; Dose

1997
Amlexanox oral paste: a novel treatment that accelerates the healing of aphthous ulcers.
    Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 1997, Volume: 18, Issue:11

    Topics: Administration, Topical; Adult; Aminopyridines; Anti-Inflammatory Agents; Chi-Square Distribution; D

1997

Other Studies

2 other studies available for amlexanox and Aphthae

ArticleYear
Low-level laser therapy versus 5% amlexanox: a comparison of treatment effects in a cohort of minor aphthous ulcers patients-a commentary.
    Oral surgery, oral medicine, oral pathology and oral radiology, 2016, Volume: 122, Issue:3

    Topics: Aminopyridines; Humans; Low-Level Light Therapy; Pain Measurement; Recurrence; Stomatitis, Aphthous

2016
[Local Treatment of stomatitis aphthosa].
    Medizinische Monatsschrift fur Pharmazeuten, 2008, Volume: 31, Issue:9

    Topics: Administration, Topical; Aminopyridines; Anti-Allergic Agents; Humans; Stomatitis, Aphthous

2008