amlexanox has been researched along with Acute Liver Injury, Drug-Induced in 3 studies
amlexanox: SRA-A antagonist;structure given in first source
amlexanox : A pyridochromene-derived monocarboxylic acid having an amino substituent at the 2-position, an oxo substituent at the 5-position and an isopropyl substituent at the 7-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment of amlexanox (50 μM) showed significantly reduced phosphorylation of TBK1 and IKKε and hepatotoxicity as confirmed by decreased levels of lactate dehydrogenase released from hepatocytes." | 1.56 | Dual TBK1/IKKε inhibitor amlexanox mitigates palmitic acid-induced hepatotoxicity and lipoapoptosis in vitro. ( Kim, B; Kim, JW; Lim, CW; Qi, J; Zhou, Z, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Qi, J | 2 |
| Zhou, Z | 2 |
| Lim, CW | 2 |
| Kim, JW | 2 |
| Kim, B | 2 |
3 other studies available for amlexanox and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Amlexanox ameliorates acetaminophen-induced acute liver injury by reducing oxidative stress in mice.
Topics: Acetaminophen; Acute Lung Injury; Aminopyridines; AMP-Activated Protein Kinases; Animals; Cells, Cul | 2019 |
Dual TBK1/IKKε inhibitor amlexanox mitigates palmitic acid-induced hepatotoxicity and lipoapoptosis in vitro.
Topics: Aminopyridines; Animals; Apoptosis; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cocultu | 2020 |