amitrole has been researched along with Thyroid Neoplasms in 10 studies
Amitrole: A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes.
amitrole : A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.
Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amitrole may cause thyroid tumor by multiple signaling pathways, and bmp2, arnt2 and wnt5 b may beits major target genes." | 1.43 | [The change of cancer-related genes expression profile in Nthy-ori-3-1 cell induced by the pesticide amitrole]. ( Han, D; Pan, H; Wang, Q; Wu, S; Xuan, Q; Yin, J, 2016) |
| "Amitrole was evaluated for carcinogenic potential in lifespan studies on Wistar rats, NMRI mice, and golden hamsters." | 1.27 | Evaluation of amitrole (aminotriazole) for potential carcinogenicity in orally dosed rats, mice, and golden hamsters. ( Boehme, K; Mohr, U; Steinhoff, D; Weber, H, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (50.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pan, H | 1 |
| Xuan, Q | 1 |
| Han, D | 1 |
| Yin, J | 1 |
| Wu, S | 1 |
| Wang, Q | 1 |
| Hoshi, S | 1 |
| Hoshi, N | 1 |
| Okamoto, M | 1 |
| Paiz, J | 1 |
| Kusakabe, T | 1 |
| Ward, JM | 1 |
| Kimura, S | 1 |
| Furukawa, A | 1 |
| Oikawa, S | 1 |
| Harada, K | 1 |
| Sugiyama, H | 1 |
| Hiraku, Y | 1 |
| Murata, M | 1 |
| Shimada, A | 1 |
| Kawanishi, S | 1 |
| Imai, T | 1 |
| Onose, J | 1 |
| Hasumura, M | 1 |
| Takizawa, T | 1 |
| Hirose, M | 2 |
| Wynford-Thomas, D | 2 |
| Stringer, BM | 1 |
| Gomez Morales, M | 1 |
| Williams, ED | 2 |
| Steinhoff, D | 1 |
| Weber, H | 1 |
| Mohr, U | 1 |
| Boehme, K | 1 |
| Hiasa, Y | 1 |
| Ohshima, M | 1 |
| Kitahori, Y | 1 |
| Yuasa, T | 1 |
| Fujita, T | 1 |
| Iwata, C | 1 |
| Santelli, G | 1 |
| de Franciscis, V | 1 |
| Portella, G | 1 |
| Chiappetta, G | 1 |
| D'Alessio, A | 1 |
| Califano, D | 1 |
| Rosati, R | 1 |
| Mineo, A | 1 |
| Monaco, C | 1 |
| Manzo, G | 1 |
| Tsuda, H | 1 |
| Hananouchi, M | 1 |
| Tatematsu, M | 1 |
| Hirao, K | 1 |
| Lemoine, NR | 1 |
| Mayall, ES | 1 |
| Thurston, V | 1 |
10 other studies available for amitrole and Thyroid Neoplasms
| Article | Year |
|---|---|
[The change of cancer-related genes expression profile in Nthy-ori-3-1 cell induced by the pesticide amitrole].
Topics: Amitrole; Cell Line, Tumor; Gene Expression Profiling; Humans; Pesticides; Signal Transduction; Thyr | 2016 |
Role of NKX2-1 in N-bis(2-hydroxypropyl)-nitrosamine-induced thyroid adenoma in mice.
Topics: Adenoma; Amitrole; Animals; Carcinogens; Female; Genes, ras; Hyperplasia; Male; Mice; Nitrosamines; | 2009 |
Oxidatively generated DNA damage induced by 3-amino-5-mercapto-1,2,4-triazole, a metabolite of carcinogenic amitrole.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Amitrole; Carcinogens; Chelating Agents; Copper; Cyclin-Dependent Kinas | 2010 |
Indomethacin induces small intestinal damage and inhibits amitrole-associated thyroid carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.
Topics: Amitrole; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Carcinogens; Cocarcinogenes | 2006 |
Vascular changes in early TSH-induced thyroid tumours in the rat.
Topics: Amitrole; Animals; Capillaries; Male; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Thyroid N | 1983 |
Evaluation of amitrole (aminotriazole) for potential carcinogenicity in orally dosed rats, mice, and golden hamsters.
Topics: Amitrole; Animals; Carcinogens; Cricetinae; Female; Iodine Radioisotopes; Liver Neoplasms; Male; Mes | 1983 |
Promoting effects of 3-amino-1,2,4-triazole on the development of thyroid tumors in rats treated with N-bis(2-hydroxypropyl)nitrosamine.
Topics: Amitrole; Animals; Carcinogens; Drug Synergism; Male; Neoplasms, Experimental; Nitrosamines; Organ S | 1982 |
Production of transgenic mice expressing the Ki-ras oncogene under the control of a thyroglobulin promoter.
Topics: Adenoma; Amitrole; Animals; Base Sequence; Chloramphenicol O-Acetyltransferase; Gene Expression Regu | 1993 |
Tumorigenic effect of 3-amino-1H-1,2,4-triazole on rat thyroid.
Topics: Amitrole; Animals; Cystadenoma; Female; Goiter; Hyperplasia; Neoplasms, Experimental; Rats; Thyroid | 1976 |
Agent-specific ras oncogene activation in rat thyroid tumours.
Topics: Amitrole; Animals; Blotting, Southern; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, | 1988 |