amitrole has been researched along with Liver Neoplasms in 8 studies
Amitrole: A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes.
amitrole : A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amitrole was evaluated for carcinogenic potential in lifespan studies on Wistar rats, NMRI mice, and golden hamsters." | 1.27 | Evaluation of amitrole (aminotriazole) for potential carcinogenicity in orally dosed rats, mice, and golden hamsters. ( Boehme, K; Mohr, U; Steinhoff, D; Weber, H, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Furukawa, A | 1 |
| Oikawa, S | 1 |
| Harada, K | 1 |
| Sugiyama, H | 1 |
| Hiraku, Y | 1 |
| Murata, M | 1 |
| Shimada, A | 1 |
| Kawanishi, S | 1 |
| Zheng, QS | 1 |
| Zhang, YT | 1 |
| Zheng, RL | 1 |
| HOSHINO, M | 1 |
| Vesselinovitch, SD | 1 |
| Steinhoff, D | 1 |
| Weber, H | 1 |
| Mohr, U | 1 |
| Boehme, K | 1 |
| Fandrey, J | 1 |
| Frede, S | 1 |
| Jelkmann, W | 1 |
| Feinstein, RN | 1 |
| Fry, RJ | 1 |
| Staffeldt, EF | 1 |
| Sumi, C | 1 |
| Yokoro, K | 1 |
| Matsushima, R | 1 |
8 other studies available for amitrole and Liver Neoplasms
| Article | Year |
|---|---|
Oxidatively generated DNA damage induced by 3-amino-5-mercapto-1,2,4-triazole, a metabolite of carcinogenic amitrole.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Amitrole; Carcinogens; Chelating Agents; Copper; Cyclin-Dependent Kinas | 2010 |
Ascorbic acid induces redifferentiation and growth inhibition in human hepatoma cells by increasing endogenous hydrogen peroxide.
Topics: alpha-Fetoproteins; Amitrole; Antioxidants; Ascorbic Acid; Carcinoma, Hepatocellular; Cell Different | 2002 |
Effect of 3-amino-1,2,4-triazole on the experimental production of liver cancer.
Topics: Amitrole; Animals; Bile Ducts, Intrahepatic; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; | 1960 |
Perinatal hepatocarcinogenesis.
Topics: Age Factors; Amitrole; Animals; Animals, Newborn; Carcinogens; Carcinoma, Hepatocellular; Female; Ge | 1983 |
Evaluation of amitrole (aminotriazole) for potential carcinogenicity in orally dosed rats, mice, and golden hamsters.
Topics: Amitrole; Animals; Carcinogens; Cricetinae; Female; Iodine Radioisotopes; Liver Neoplasms; Male; Mes | 1983 |
Role of hydrogen peroxide in hypoxia-induced erythropoietin production.
Topics: Amitrole; Base Sequence; Carcinoma, Hepatocellular; Catalase; DNA Primers; Dose-Response Relationshi | 1994 |
Carcinogenic and antitumor effects of aminotriazole on acatalasemic and normal catalase mice.
Topics: Amitrole; Animals; Antineoplastic Agents; Carcinogens; Catalase; Female; Liver Neoplasms; Lymphoma; | 1978 |
Inhibition by 3-amino-1H-1,2,4-triazole of hepatic tumorigenesis induced by diethylstilbestrol alone or combined with N-nitrosobutylurea in WF rats.
Topics: Amitrole; Animals; Body Weight; Diethylstilbestrol; Liver Neoplasms; Male; Nitrosourea Compounds; Or | 1985 |