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amitrole and Hyperplasia

amitrole has been researched along with Hyperplasia in 8 studies

Amitrole: A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes.
amitrole : A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.

Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.

Research Excerpts

ExcerptRelevanceReference
"Amitrole was administered to mice in drinking water at a dose of 1% for 6 months."1.27Amitrole: strain differences in morphological response of the liver following subchronic administration to mice. ( Hayashi, Y; Makino, S; Mori, S; Ohhara, T; Takeuchi, Y; Tochino, Y; Toyama, M, 1985)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19905 (62.50)18.7374
1990's1 (12.50)18.2507
2000's1 (12.50)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hoshi, S1
Hoshi, N1
Okamoto, M1
Paiz, J1
Kusakabe, T1
Ward, JM1
Kimura, S1
Joddar, B1
Reen, RK1
Firstenberg, MS1
Varadharaj, S1
McCord, JM1
Zweier, JL1
Gooch, KJ1
Wynford-Thomas, D2
Stringer, BM2
Williams, ED1
Tsuda, H1
Hananouchi, M1
Tatematsu, M1
Hirose, M1
Hirao, K1
Groch, KM1
Clifton, KH1
Mori, S1
Takeuchi, Y1
Toyama, M1
Makino, S1
Ohhara, T1
Tochino, Y1
Hayashi, Y1
Gaines, TB1
Kimbrough, RD1
Linder, RE1

Other Studies

8 other studies available for amitrole and Hyperplasia

ArticleYear
Role of NKX2-1 in N-bis(2-hydroxypropyl)-nitrosamine-induced thyroid adenoma in mice.
    Carcinogenesis, 2009, Volume: 30, Issue:9

    Topics: Adenoma; Amitrole; Animals; Carcinogens; Female; Genes, ras; Hyperplasia; Male; Mice; Nitrosamines;

2009
Protandim attenuates intimal hyperplasia in human saphenous veins cultured ex vivo via a catalase-dependent pathway.
    Free radical biology & medicine, 2011, Mar-15, Volume: 50, Issue:6

    Topics: Amitrole; Antioxidants; Blotting, Western; Catalase; Cell Proliferation; Drugs, Chinese Herbal; Endo

2011
Circadian rhythm of mitotic activity in normal and hyperplastic rat thyroid.
    Acta endocrinologica, 1982, Volume: 100, Issue:1

    Topics: Amitrole; Animals; Circadian Rhythm; Hyperplasia; Male; Mitosis; Rats; Rats, Inbred Strains; Thyroid

1982
Mast cell hyperplasia during goitrogen-induced thyroid growth - a quantitative study.
    Acta endocrinologica, 1982, Volume: 101, Issue:3

    Topics: Amitrole; Animals; Cell Count; Hyperplasia; Male; Mast Cells; Organ Size; Rats; Rats, Inbred Strains

1982
Tumorigenic effect of 3-amino-1H-1,2,4-triazole on rat thyroid.
    Journal of the National Cancer Institute, 1976, Volume: 57, Issue:4

    Topics: Amitrole; Animals; Cystadenoma; Female; Goiter; Hyperplasia; Neoplasms, Experimental; Rats; Thyroid

1976
The effects of goitrogenesis, involution, and goitrogenic rechallenge on the clonogenic cell content of the rat thyroid.
    Acta endocrinologica, 1992, Volume: 126, Issue:6

    Topics: Amitrole; Animals; Cell Division; Chlorates; Clone Cells; DNA; Goiter; Hyperplasia; Male; Rats; Rats

1992
Amitrole: strain differences in morphological response of the liver following subchronic administration to mice.
    Toxicology letters, 1985, Volume: 29, Issue:2-3

    Topics: Amitrole; Animals; Female; Hyperplasia; Immunity, Cellular; Liver; Liver Neoplasms, Experimental; Mi

1985
The toxicity of amitrole in the rat.
    Toxicology and applied pharmacology, 1973, Volume: 26, Issue:1

    Topics: Amitrole; Animals; Body Weight; Diet; Female; Herbicides; Hyperplasia; Intubation, Gastrointestinal;

1973