amitrole has been researched along with Graves Disease in 2 studies
Amitrole: A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes.
amitrole : A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.
Graves Disease: A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (100.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Lisi, S | 1 |
Pinchera, A | 2 |
McCluskey, RT | 2 |
Willnow, TE | 1 |
Refetoff, S | 1 |
Marcocci, C | 1 |
Vitti, P | 1 |
Menconi, F | 1 |
Grasso, L | 1 |
Luchetti, F | 1 |
Collins, AB | 2 |
Marino, M | 2 |
Chiovato, L | 1 |
Mitsiades, N | 1 |
Latrofa, F | 1 |
Andrews, D | 1 |
Tseleni-Balafouta, S | 1 |
1 trial available for amitrole and Graves Disease
Article | Year |
---|---|
Circulating thyroglobulin transcytosed by thyroid cells in complexed with secretory components of its endocytic receptor megalin.
Topics: Adult; Aged; Amitrole; Animals; Autoantigens; Blotting, Western; Cells, Cultured; Epithelial Cells; | 2000 |
1 other study available for amitrole and Graves Disease
Article | Year |
---|---|
Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: a control mechanism for thyroid hormone release.
Topics: Adult; Amitrole; Animals; Dose-Response Relationship, Drug; Endocytosis; Enzyme-Linked Immunosorbent | 2003 |